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https://www.readbyqxmd.com/read/29054128/combination-varenicline-bupropion-treatment-benefits-highly-dependent-smokers-in-an-adaptive-smoking-cessation-paradigm
#1
Jed E Rose, Frédérique M Behm
Introduction: This study replicated and extended results of a previous trial, which found that combination varenicline/bupropion treatment increased smoking abstinence in smokers who were male, highly dependent, and who did not respond to prequit nicotine patch treatment with a >50% reduction in expired-air carbon monoxide in the first week. Methods: One hundred and twenty-two male nicotine patch nonresponders and 52 responders were identified. Smokers in each group were randomized to receive 12 weeks of varenicline plus bupropion treatment versus varenicline plus placebo...
August 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29054125/external-validation-of-a-cancer-risk-prediction-model-for-suspected-head-and-neck-cancer-referrals
#2
T Tikka, V Paleri, K MacKenzie
Head and neck cancer (HNC) affects more than 9000 new patients every year in England and Wales with an additional 1200 in Scotland. (1,2) Patients are urgently referred to head and neck clinics for further assessment when a suspicion of cancer is raised in the primary care setting. In England, the referral criteria are based on the NICE recommendations for symptoms associated with HNC. (2) A different combination of symptoms is described in the Scottish cancer referral guidelines. (3) There is currently no unified referral proforma across the different UK cancer networks...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054121/multisensory-modulation-of-experimentally-evoked-perceptual-distortion-of-the-face
#3
Lilja K Dagsdóttir, Valeria Bellan, Ina Skyt, Lene Vase, Lene Baad-Hansen, Eduardo Castrillon, Peter Svensson
Chronic orofacial pain patients often perceive the painful face area as 'swollen' without clinical signs, i.e., a perceptual distortion (PD). Local anesthetic (LA) injections in healthy participants are also associated with PD OBJECTIVE: The aim was to explore whether PD evoked by LA into the infraorbital region of could be modulated by adding mechanical stimulation (MS) to the affected area METHODS: MS was given with a brush and a 128 mN von Frey filament. First, sixty healthy participants were randomly divided into three groups: 1) LA control, 2) LA with MS, 3) Isotonic solution (ISO) with MS as an additional control condition...
October 20, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29054113/post-operative-corticosteroid-irrigation-for-chronic-rhinosinusitis-after-endoscopic-sinus-surgery-a-meta-analysis
#4
Ho Young Yoon, Ho Seok Lee, In Hye Kim, Se Hwan Hwang
BACKGROUND: Recently, topical steroid therapy delivery using high-volume sinonasal irrigations has been used more frequently, following endoscopic sinus surgery (ESS), to improve drug delivery into the paranasal sinuses. OBJECTIVE: The goal of this study was to perform a systematic review with meta-analysis of the efficacy of steroid nasal irrigation on postoperative management of CRS following ESS. METHODS: Five databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to March 2017 were independently reviewed by two researchers...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054103/preparedness-education-in-the-baccalaureate-nursing-curriculum-an-authentic-clinical-experience
#5
Dawn M Bowker, Brandi J Tomlinson
Healthy People 2020 supports the preparation of nurse graduates to assess emergency preparedness needs of defined populations and includes preparedness as one of its objectives. Natural disaster preparedness is addressed through the lens of community-centered care that meets the Quality and Safety Education for Nurses domains of patient-centered care and teamwork and collaboration. This article discusses the development of an authentic clinical experience through collaboration between the American Red Cross and a baccalaureate nursing program...
November 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29054093/the-role-of-pazopanib-on-tumour-angiogenesis-and-in-the-management-of-cancers-a-review
#6
REVIEW
Dinesh Kumar Chellappan, Jestin Chellian, Zhao Yin Ng, Yan Jinn Sim, Chiu Wei Theng, Joyce Ling, Mei Wong, Jia Hui Foo, Goh Jun Yang, Li Yu Hang, Saranyah Nathan, Yogendra Singh, Gaurav Gupta
Pazopanib is a relatively new compound to be introduced into the chemotherapy field. It is thought to have decent anti-angiogenic properties, which gives an additional hope for the treatment of certain types of cancers. A systematic review solely discussing about pazopanib and its anti-angiogenic effect is yet to be published to date, despite several relevant clinical trials being conducted over the recent years. In this review, we aim to investigate the mechanism of pazopanib's anti-angiogenic effect and its effectiveness in treating several cancers...
October 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29054089/molecular-characterization-of-cryptococcus-neoformans-and-cryptococcus-gattii-from-environmental-sources-and-genetic-comparison-with-clinical-isolates-in-apulia-italy
#7
Maria Teresa Montagna, Antonella De Donno, Giuseppina Caggiano, Francesca Serio, Osvalda De Giglio, Francesco Bagordo, R D'Amicis, Shawn R Lockhart, Massimo Cogliati
The present study investigated the environmental distribution of Cryptococcus neoformans and C. gattii species complex molecular types, mating types and sequence types in Apulia, a region of Southern Italy. A total of 2078 specimens from arboreal and animal sources were analyzed. The percentage of positive samples was similar among both arboreal and animal specimens: 4.2% vs. 5.1% for C. neoformans species complex and 0.6% vs. 1.4% for C. gattii species complex. Molecular typing identified 78 isolates as VNI (76 αA and two aA), one as AD-hybrid αADa, and 16 as VGI aB...
October 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29054076/genetic-polymorphisms-in-angiogenesis-related-genes-are-associated-with-worse-progression-free-survival-of-patients-with-advanced-gastrointestinal-stromal-tumours-treated-with-imatinib
#8
Michiel C Verboom, Jacqueline S L Kloth, Jesse J Swen, Tahar van der Straaten, Judith V M G Bovée, Stefan Sleijfer, Anna K L Reyners, Ron H J Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom
BACKGROUND: Imatinib 400 mg per day is first-line therapy for patients with gastrointestinal stromal tumours (GISTs). Although clinical benefit is high, progression-free survival (PFS) is variable. This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST. METHODS: In 227 patients a pharmacogenetic pathway analysis was performed...
October 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29054070/bedside-implantation-of-a-new-temporary-vena-cava-inferior-filter-safety-and-efficacy-results-of-the-european-angel-registry
#9
Stefan Baumann, Tobias Becher, Konstantinos Giannakopoulos, Claude Jabbour, Marlon Rutsch, Christian Fastner, Ibrahim El-Battrawy, Uzair Ansari, Dirk Lossnitzer, Michael Behnes, Angelika Alonso, Thomas Kirschning, Guido Michels, Daniel Stern, Ruediger Dissmann, Olaf Kueck, Fabio Silvio Taccone, Carl Waldmann, Nicholas Bunker, Maurizio Postiglione, Martin Borggrefe, Ibrahim Akin
PURPOSE: Pulmonary embolism (PE) is a frequently occurring complication in critically ill patients. Simultaneous occurrence of PE and life-threatening bleeding, may render medical anticoagulation impossible. For these patients, inferior vena cava filters (IVCF) present a valuable therapeutic alternative. The Angel® catheter is a novel IVCF that provides temporary protection from PE and is implanted at bedside. The primary objective of the European Angel® catheter registry is to evaluate the safety and efficacy of this IVCF...
October 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#10
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29054045/analysis-of-data-collected-from-right-and-left-limbs-accounting-for-dependence-and-improving-statistical-efficiency-in-musculoskeletal-research
#11
Sarah Stewart, Janet Pearson, Keith Rome, Nicola Dalbeth, Alain C Vandal
OBJECTIVES: Statistical techniques currently used in musculoskeletal research often inefficiently account for paired-limb measurements or the relationship between measurements taken from multiple regions within limbs. This study compared three commonly used analysis methods with a mixed-models approach that appropriately accounted for the association between limbs, regions, and trials and that utilised all information available from repeated trials. METHOD: Four analysis were applied to an existing data set containing plantar pressure data, which was collected for seven masked regions on right and left feet, over three trials, across three participant groups...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29054042/spontaneous-hemoperitoneum-in-pregnancy-ship-and-endometriosis-a-systematic-review-of-the-recent-literature
#12
REVIEW
Marit C I Lier, Romana F Malik, Johannes C F Ket, Cornelis B Lambalk, Ivo A Brosens, Velja Mijatovic
Spontaneous Hemoperitoneum in Pregnancy (SHiP), an unprovoked (nontraumatic) intraperitoneal bleeding in pregnancy (up to 42days postpartum), is associated with serious adverse pregnancy outcomes. To evaluate the clinical consequences of SHiP and its association with endometriosis, a systematic review was conducted according to the PRISMA guidelines. PubMed, Embase.com and Thomson Reuters/Web of Science were searched for articles published since the latest review (August 2008) until September 2016. After assessment for eligibility, forty-four articles were included in this systematic review, describing 59 cases of SHiP...
October 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29054041/cardiovascular-obstetric-and-neonatal-outcomes-in-women-with-previous-fontan-repair
#13
REVIEW
S J Bonner, O Asghar, A Roberts, S Vause, B Clarke, B Keavney
OBJECTIVES: To determine cardiovascular, obstetric and neonatal outcomes of pregnancies in women who have a Fontan circulation. METHODS: A retrospective case note review of all women with a Fontan circulation who attended the joint obstetric cardiac antenatal clinic at St Mary's Hospital, Manchester (UK) between 2004 and 2016 was performed. RESULTS: In total, there were 19 pregnancies in 9 women with a history of Fontan repair. 23 women with univentricular physiology attended in this time period...
October 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29054038/epileptic-headache-a-rare-form-of-painful-seizure
#14
REVIEW
Carlo Cianchetti, Filippo Dainese, Maria Giuseppina Ledda, Giuliano Avanzini
PURPOSE: To describe the concept, features and mechanisms of epileptic headache (EH). METHODS: Analysis of all published articles concerning EH and related subjects. RESULTS: There are more than 30 published case studies of patients with headache as the only manifestation of a seizure, a condition that has been variously called "EH", "ictal epileptic headache", "hemicrania epileptica", "cephalic pain seizure". It is necessary to differentiate EH from "migralepsy" and "ictal non-epileptic headache"...
October 13, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29054017/hyperventilation-and-electroconvulsive-therapy-a-literature-review
#15
REVIEW
Jorge Gómez-Arnau, Aida de Arriba-Arnau, Javier Correas-Lauffer, Mikel Urretavizcaya
BACKGROUND: Hyperventilation has been proposed as an augmentation strategy in electroconvulsive therapy (ECT) in accordance with its proconvulsant effect. OBJECTIVE: This study reviews the existing literature on the application of hyperventilation in ECT, its efficacy, and tolerance. METHODS: A systematic search was performed in PubMed and EMBASE databases. Search terms ('electroconvulsive therapy' and 'hyperventilation', 'ventilation', 'hyperoxygenation', 'hyperoxia', 'hypocapnia') were used to retrieve works from 1966 to June 2016...
September 23, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29054012/the-role-of-long-noncoding-rnas-in-cancer-the-dark-matter-matters
#16
REVIEW
Xiaowen Hu, Anil K Sood, Chi V Dang, Lin Zhang
Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs are associated with imbalanced gene regulation and aberrant biological processes that contribute to malignant transformation. The functions and therapeutic potential of cancer-related lncRNAs have attracted considerable interest in the past few years...
October 17, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29053990/persistence-and-infectivity-of-zika-virus-in-semen-after-returning-from-endemic-areas-report-of-5-cases
#17
S García-Bujalance, A Gutiérrez-Arroyo, F De la Calle, M Díaz-Menéndez, Jose R Arribas, J García-Rodríguez, M Arsuaga
BACKGROUND: There are limited data about the persistence and infectivity of Zika virus in semen of symptomatic travelers returning from endemic areas and even less data in asymptomatic cases. OBJECTIVE: We investigated the persistence and infectivity of ZIKA virus in semen in five patients with Zika virus infection returning to Spain from endemic areas. STUDY DESIGN: We evaluated the epidemiological, clinical and virological characteristic of the five patients...
October 13, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29053989/psychometric-properties-of-the-child-anxiety-life-interference-scale-preschool-version
#18
Tamsyn J Gilbertson, Amy J Morgan, Ronald M Rapee, Heidi J Lyneham, Jordana K Bayer
Despite growing recognition of childhood anxiety as a common and often debilitating clinical concern, we have limited knowledge of the particular ways in which anxiety interferes with daily life for young children who have not yet entered formal schooling. The present study evaluated the psychometric properties of the Child Anxiety Life Interference Scale - Preschool Version (CALIS-PV). The CALIS-PV is a brief (18 item) parent-report measure of the impacts of a young child's anxiety on their own life and that of her or his parent...
October 13, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29053987/the-role-of-executive-functions-and-psychiatric-symptom-severity-in-the-allen-cognitive-levels
#19
Sarah Schubmehl, Samuel H Barkin, Doug Cort
This study examined the relationship between Allen Cognitive Level (ACL) and psychiatric symptom severity, level of nursing support required to complete activities of daily living (ADLs), and post-hospitalization discharge disposition in a sample of 193 acute psychiatric inpatients. A subsample of 31 participants with acute psychotic disorders were administered three measures of executive functioning in order to examine the convergent validity between ACL and basic sequencing and shifting, phonemic fluency, and visuospatial construction...
October 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29053983/conceptualizing-trust-in-community-academic-research-partnerships-using-concept-mapping-approach-a-multi-ctsa-study
#20
Gaurav Dave, Leah Frerichs, Jennifer Jones, Mimi Kim, Jennifer Schaal, Stefanie Vassar, Deepthi Varma, Catherine Striley, Corrine Ruktanonchai, Adina Black, Jennifer Hankins, Nakita Lovelady, Crystal Cene, Melissa Green, Tiffany Young, Shristi Tiwari, Ann Cheney, Linda Cottler, Greer Sullivan, Arleen Brown, Jessica Burke, Giselle Corbie-Smith
OBJECTIVES: Collaborations between communities, healthcare practices and academic institutions are a strategy to address health disparities. Trust is critical in the development and maintaining of effective collaborations. The aim of this pilot study was to engage stakeholders in defining determinants of trust in community academic research partnerships and to develop a framework for measuring trust. METHODS: The study was conducted by five collaborating National Institute of Health' Clinical and Translational Sciences Awardees...
October 12, 2017: Evaluation and Program Planning
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