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https://www.readbyqxmd.com/read/29913540/-significance-of-matrix-augmented-bone-marrow-stimulation-for-treatment-of-cartilage-defects-of-the-knee-a-consensus-statement-of-the-dgou-working-group-on-tissue-regeneration
#1
Philipp Niemeyer, Christoph Becher, Matthias Buhs, Stefan Fickert, Kolja Gelse, Daniel Günther, Raphael Kaelin, Peter Kreuz, Jörg Lützner, Stefan Nehrer, Henning Madry, Stefan Marlovits, Julian Mehl, Henning Ott, Matthias Pietschmann, Gunther Spahn, Thomas Tischer, Martin Volz, Markus Walther, Götz Welsch, Johannes Zellner, Wolfgang Zinser, Peter Angele
Surgical principles for treatment of full-thickness cartilage defects of the knee include bone marrow stimulation techniques (i.e. arthroscopic microfracturing) and transplantation techniques (i.e. autologous chondrocyte implantation and osteochondral transplantation). On the basis of increasing scientific evidence, indications for these established therapeutical concepts have been specified and clear recommendations for practical use have been given. Within recent years, matrix-augmented bone marrow stimulation has been established as a new treatment concept for chondral lesions...
June 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29913536/hemostasis-in-the-very-young
#2
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913535/thrombocytopenia-and-platelet-dysfunction-in-acute-tropical-infectious-diseases
#3
Indri Hapsari Putri, Rahajeng N Tunjungputri, Philip G De Groot, Andre J van der Ven, Quirijn de Mast
Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913532/ligation-assisted-endoscopic-submucosal-resection-with-apical-mucosal-incision-to-treat-gastric-subepithelial-tumors-originating-from-the-muscularis-propria
#4
Dingguo Zhang, Qiuling Lin, Ruiyue Shi, Lisheng Wang, Jun Yao, Yanhui Tian
BACKGROUND:  This study aimed to evaluate the clinical efficacy, safety, and feasibility of performing endoscopic submucosal resection with a ligation device (ESMR-L) after apical mucosal incision (AMI) for the treatment of gastric subepithelial tumors originating from the muscularis propria (SET-MPs). METHODS:  14 patients with gastric SET-MPs were treated by ESMR-L with AMI between December 2016 and May 2017. The complete resection rate, operation duration, and postoperative complications were collected...
June 18, 2018: Endoscopy
https://www.readbyqxmd.com/read/29913529/a-pilot-study-evaluating-cerebral-vasculitis-in-kawasaki-s-disease
#5
Jung Sook Yeom, Young Hye Cho, Chung Mo Koo, Jin Su Jun, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD ( n  = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [ n  = 5], enteroviral meningitis [ n  = 10], nonspecific viral illness without central nervous system involvement [ n  = 10])...
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#6
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29913523/dental-imaging-a-basic-guide-for-the-radiologist
#7
Max Masthoff, Mirjam Gerwing, Malte Masthoff, Maximilian Timme, Johannes Kleinheinz, Markus Berninger, Walter Heindel, Moritz Wildgruber, Christoph Schülke
BACKGROUND:  As dental imaging accounts for approximately 40 % of all X-ray examinations in Germany, profound knowledge of this topic is essential not only for the dentist but also for the clinical radiologist. This review focuses on basic imaging findings regarding the teeth. Therefore, tooth structure, currently available imaging techniques and common findings in conserving dentistry including endodontology, periodontology, implantology and dental trauma are presented. METHODS:  Literature research on the current state of dental radiology was performed using Pubmed...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913520/subependymomas-characteristics-of-a-leave-me-alone-lesion
#8
Sara Kammerer, Monika Mueller-Eschner, Arne Lauer, Anna-Luisa Luger, Johanna Quick-Weller, Kea Franz, Patrick Harter, Joachim Berkefeld, Marlies Wagner
PURPOSE:  Intracranial subependymomas are rare, mostly asymptomatic tumours, which are often found incidentally and therefore did not receive much attention in previous literature. By being classified as benign grade I in the WHO classification of tumours of the central nervous system, they are given a special status compared to the other ependymal tumours. Tumor recurrences are a rarity, spinal "drop metastases" do not occur. While etiological, pathological and therapeutic characteristics have been subject of several publications over the last few decades and have meanwhile been well studied, the imaging characteristics are much less well received...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913486/prognostic-implications-of-single-sample-confirmatory-testing-for-undiagnosed-diabetes-a-prospective-cohort-study
#9
Elizabeth Selvin, Dan Wang, Kunihiro Matsushita, Morgan E Grams, Josef Coresh
Background: Current clinical definitions of diabetes require repeated blood work to confirm elevated levels of glucose or hemoglobin A1c (HbA1c) to reduce the possibility of a false-positive diagnosis. Whether 2 different tests from a single blood sample provide adequate confirmation is uncertain. Objective: To examine the prognostic performance of a single-sample confirmatory definition of undiagnosed diabetes. Design: Prospective cohort study...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913459/clinical-characteristics-and-prognosis-of-pregnancy-associated-breast-cancer-poor-survival-of-luminal-b-subtype
#10
Soo Youn Bae, Seung Pil Jung, Eun Sung Jung, Sung Min Park, Se Kyung Lee, Jong Han Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam
BACKGROUND: Pregnancy-associated breast cancer (PABC) is rare and is generally defined as breast cancer diagnosed during pregnancy or within 1 year of delivery. The average ages of marriage and childbearing are increasing, and PABC is expected to also increase. This study is intended to increase understanding of the characteristics of PABC. METHODS: A database of 2,810 patients with breast cancer diagnosed when they were less than 40 years of age was reviewed. The clinicopathological factors and survival of PABC (40 patients) were compared to those of patients with young breast cancer (YBC, non-pregnant or over 12 months after delivery; 2,770 patients)...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913454/ra190-a-proteasome-subunit-adrm1-inhibitor-suppresses-intrahepatic-cholangiocarcinoma-by-inducing-nf-kb-mediated-cell-apoptosis
#11
Guang-Yang Yu, Xuan Wang, Su-Su Zheng, Xiao-Mei Gao, Qing-An Jia, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen, Qiong-Zhu Dong, Ming Lu, Lun-Xiu Qin
BACKGROUND/AIMS: Effective drug treatment for intrahepatic cholangiocarcinoma (ICC) is currently lacking. Therefore, there is an urgent need for new targets and new drugs that can prolong patient survival. Recently targeting the ubiquitin proteasome pathway has become an attractive anti-cancer strategy. In this study, we aimed to evaluate the therapeutic effect of and identify the potential mechanisms involved in targeting the proteasome subunit ADRM1 for ICC. METHODS: The expression of ADRM1 and its prognostic value in ICC was analyzed using GEO and TCGA datasets, tumor tissues, and tumor tissue arrays...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913453/uremic-pruritus-is-associated-with-two-year-cardiovascular-mortality-in-long-term-hemodialysis-patients
#12
Cheng-Hao Weng, Ching-Chih Hu, Tzung-Hai Yen, Ching-Wei Hsu, Wen-Hung Huang
BACKGROUND/AIMS: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality in patients undergoing dialysis. Studies on the correlation between cardiovascular or infection related mortality and UP are limited. METHODS: We analyze 866 maintenance hemodialysis (MHD) patients in our hemodialysis centers. Clinical parameters and 24-month cardiovascular and infection-related mortality are recorded...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913448/rapid-electrical-stimulation-increased-cardiac-apoptosis-through-disturbance-of-calcium-homeostasis-and-mitochondrial-dysfunction-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#13
Le Geng, Zidun Wang, Chang Cui, Yue Zhu, Jiaojiao Shi, Jiaxian Wang, Minglong Chen
BACKGROUND/AIMS: Heart failure induced by tachycardia, the most common arrhythmia, is frequently observed in clinical practice. This study was designed to investigate the underlying mechanisms. METHODS: Rapid electrical stimulation (RES) at a frequency of 3 Hz was applied on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for 7 days, with 8 h/day and 24 h/day set to represent short-term and long-term tachycardia, respectively. Age-matched hiPSC-CMs without electrical stimulation or with slow electrical stimulation (1 Hz) were set as no electrical stimulation (NES) control or low-frequency electrical stimulation (LES) control...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913447/perioperative-anaphylaxis-including-kounis-syndrome-due-to-selective-cefazolin-allergy
#14
Inês Mota, Ângela Gaspar, Mário Morais-Almeida
BACKGROUND: Perioperative use of cefazolin has been associated with severe allergic reactions, and patients are usually labelled as allergic to penicillin afterwards. The aim of our study was to describe a group of patients with immediate reactions to cefazolin, with proven selective hypersensitivity reactions. METHODS: Systematic review of all patients followed at our drug centre with cefazolin-related reactions, between January 2012 and December 2016. All patients were investigated according to the European Network for Drug Allergy (ENDA) recommendations through skin testing (major and minor penicillin determinants, penicillin, amoxicillin, cefazolin, cefuroxime and ceftriaxone) and oral challenges tests...
June 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29913446/segmentation-of-dilated-hemorrhoidal-veins-in-hemorrhoidal-disease
#15
Lucio Díaz-Flores, Ricardo Gutiérrez, Miriam González-Gómez, Pino García, Francisco J Sáez, Lucio Díaz-Flores, José Luis Carrasco, Juan F Madrid
Vein segmentation is a vascular remodeling process mainly studied in experimental conditions and linked to hemodynamic factors, with clinical implications. The aim of this work is to assess the morphologic characteristics, associated findings, and mechanisms that participate in vein segmentation in humans. To this end, we examined 156 surgically obtained cases of hemorrhoidal disease. Segmentation occurred in 65 and was most prominent in 15, which were selected for serial sections, immunohistochemistry, and immunofluorescence procedures...
June 18, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29913438/race-age-and-gender-based-characteristics-and-toxicities-of-targeted-therapies-on-phase-i-trials
#16
Taofeek K Owonikoko, Adeniyi K Busari, Sungjin Kim, Zhengjia Chen, Adebowale Akintayo, Colleen Lewis, Bradley C Carthon, Olatunji B Alese, Bassel F El-Rayes, Suresh S Ramalingam, R Donald Harvey
BACKGROUND: The impact of age-, gender-, and race-based differences on safety and efficacy in phase I clinical trials has not been well studied. METHODS: We analyzed data from phase I clinical trials evaluating targeted biologic agents in patients with advanced solid malignancies. Race and gender distribution of enrolled patients was compared to the referral population demographics at the city, metro, and state levels. The association between age, gender, and race with type, frequency, and severity of treatment-emergent toxicities and clinical benefit was assessed using univariate and multivariable models...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913434/factors-influencing-child-protection-professionals-decision-making-and-multidisciplinary-collaboration-in-suspected-abusive-head-trauma-cases-a-qualitative-study
#17
Laura E Cowley, Sabine Maguire, Daniel M Farewell, Harriet D Quinn-Scoggins, Matthew O Flynn, Alison M Kemp
Clinicians face unique challenges when assessing suspected child abuse cases. The majority of the literature exploring diagnostic decision-making in this field is anecdotal or survey-based and there is a lack of studies exploring decision-making around suspected abusive head trauma (AHT). We aimed to determine factors influencing decision-making and multidisciplinary collaboration in suspected AHT cases, amongst 56 child protection professionals. Semi-structured interviews were conducted with clinicians (25), child protection social workers (10), legal practitioners (9, including 4 judges), police officers (8), and pathologists (4), purposively sampled across southwest United Kingdom...
June 15, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29913424/postponement-of-canine-puberty-by-neonatal-administration-of-a-long-term-release-gnrh-superagonist
#18
M Faya, C Marchetti, M Priotto, M Grisolía, F D'Francisco, C Gobello
The objective of this study was to assess the efficiency and clinical safety of postnatal administration of a GnRH agonist on canine puberty postponement. Sexual steroids and histological gonadal changes were also described. Twenty-four littermate puppies were randomly assigned to: Deslorelin acetate 18.8 mg sc (DESLO; n = 12) or Placebo: sc (PLACE; n = 12) postnatally. The dogs were clinically and endocrinologically followed up until puberty when they were gonadectomized and their gonads histomorphometrically studied...
June 2, 2018: Theriogenology
https://www.readbyqxmd.com/read/29913409/mir-22-3p-targeting-alpha-enolase-1-regulates-the-proliferation-of-retinoblastoma-cells
#19
Yan Liu, Huanhuan Li, Yao Liu, Zhichao Zhu
OBJECTIVE: This study sought to explore the role of alpha-Enolase 1 (ENO1) in retinoblastoma (RB) which remains uncertain. METHODS: The expression of ENO1 in RB cell lines was examined by RT-qPCR and western blot. The biological function of ENO1 on cell proliferation in RB was determined in vitro. The predicted target of ENO1 was validated by dual-luciferase reporter assay and rescue experiment. The validation of clinical tissue samples was performed by RT-qPCR...
June 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29913395/the-effect-of-nonsteroidal-anti-inflammatory-drugs-on-bone-healing-in-humans-a-qualitative-systematic-review
#20
REVIEW
Alain Borgeat, Christian Ofner, Andrea Saporito, Mazda Farshad, José Aguirre
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in postoperative pain management. While an increasing number of in vitro and animal studies point toward an inhibitory effect of NSAIDs on bone healing process, the few existing retro- and prospective clinical studies present conflicting data. DESIGN: The aim of this qualitative, systematic review was to investigate the impact of perioperative use of NSAIDs in humans on postoperative fracture/spinal fusion healing compared to other used analgesics measured as fracture nonunion with radiological control...
June 15, 2018: Journal of Clinical Anesthesia
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