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https://www.readbyqxmd.com/read/28813547/an-experimental-and-numerical-study-of-hybrid-iii-dummy-response-to-simulated-underbody-blast-impacts
#1
Karthik Somasundaram, Anil Kalra, Don Sherman, Paul Begeman, King H Yang, John M Cavanaugh
Anthropometric test devices (ATDs) such as Hybrid III dummy have been widely used in automotive crash tests to evaluate the risks of injury at different body regions. In recent years, researchers have started using automotive ATDs to study the high-speed vertical loading response caused by underbelly blast (UBB) impacts. This study analyzed the Hybrid III dummy responses to short-duration large magnitude vertical acceleration in a laboratory setup. Two unique test conditions were investigated using a horizontal sled system to simulate the UBB loading conditions...
August 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28812394/the-use-of-sustained-low-efficiency-dialysis-sled-in-massive-paracetamol-overdose
#2
Anselm Wong, Roger L K Tong, Liam Ryan, Tim Crozier, Andis Graudins
CONTEXT: Massive paracetamol ingestion causing mitochondrial dysfunction is uncommon. Use of sustained low-efficiency dialysis (SLED) to improve acidaemia and enhance paracetamol elimination has not been previously described. CASE DETAILS: A 44-year-old male presented to the emergency department 2.5 hours post overdose of 200 g (2.5 g/kg) of paracetamol. Examination revealed a BP 85/60 mmHg, pulse 112 bpm, temperature 33.9 °C and blood glucose of 13...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28794456/activated-nk-cells-cause-placental-dysfunction-and-miscarriages-in-fetal-alloimmune-thrombocytopenia
#3
Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G Sled, Stephen J Lye, Jelena Brkić, Chun Peng, Petter Höglund, B Anne Croy, S Lee Adamson, Xiao-Yan Wen, Duncan J Stewart, John Freedman, Heyu Ni
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal-fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28724961/coherence-properties-of-different-light-sources-and-their-effect-on-the-image-sharpness-and-speckle-of-holographic-displays
#4
Yuanbo Deng, Daping Chu
Coherence properties of different light sources and how they affect the image quality of holographic display are investigated. Temporal coherence is related to the intrinsic spectrum bandwidth of the light source, while spatial coherence can be affected by the size of the light source and propagation distance in use. These two coherence properties are measured for various light sources of diode-pumped solid-state (DPSS) laser, laser diode (LD), light emitting diode (LED), super luminescent light emitting diode (sLED) and micro light emitting diode (mLED) in different settings, together with the quality of the holographic reconstructed images...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719778/medial-malleoli-fractures-clinical-comparison-between-newly-designed-sled-device-and-conventional-screws
#5
Hemil Maniar, Harish Kempegowda, Akhil A Tawari, Michael R Rutter, Amrut Borade, Gerard Cush, Daniel S Horwitz
BACKGROUND: The Trimed Medial Malleolar Sled is a newer device designed to treat medial malleolus fracture. The purpose of this study was to compare the outcome of medial malleolar fractures treated with the sled and conventional malleolar screws. METHODS: After obtaining an institutional review board approval, we conducted a retrospective study to identify all skeletally mature patients who sustained an ankle fracture with medial malleolar involvement treated with the sled and we identified a matched cohort treated with conventional malleolar screws...
August 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28700513/sled-towing-acutely-decreases-acceleration-sprint-time
#6
Megan A Wong, Ian J Dobbs, Casey M Watkins, Saldiam R Barillas, A Lin, David C Archer, Robert G Lockie, Jared W Coburn, Lee E Brown
Sled towing is a common form of overload training in sports to develop muscular strength for sprinting. This type of training leads to acute and chronic outcomes. Acute training potentially leads to postactivation potentiation (PAP), which is when subsequent muscle performance is enhanced following a preload stimulus. The purpose of this study was to determine differences between rest intervals following sled towing on acute sprint speed. Twenty healthy recreationally trained males (age= 22.3 ± 2.4yrs, height= 176...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28696780/evaluation-of-the-effectiveness-of-toe-board-energy-absorbing-material-for-foot-ankle-and-lower-leg-injury-reduction
#7
John P Patalak, Joel D Stitzel
OBJECTIVE: Since 2000 numerous improvements have been made to the National Association for Stock Car Auto Racing, Incorporated (NASCAR®) driver restraint system, resulting in improved crash protection for motorsports drivers. Advancements have included seats, head and neck restraints (HNR), seat belt restraint systems, driver helmets and others. These enhancements have increased protection for drivers from severe crash loading. Extending protection to the driver's extremities remains challenging...
July 11, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28686319/magnetic-resonance-thermometry-of-flowing-blood
#8
Chinthaka C Heyn, Jonathan Bishop, Kyle Duffin, Wayne Lee, Jun Dazai, Shoshana Spring, Brian J Nieman, John G Sled
Blood temperature is a key determinant of tissue temperature and can be altered under normal physiological states, such as exercise, in diseases such as stroke or iatrogenically in therapies which modulate tissue temperature, such as therapeutic hypothermia. Currently available methods for the measurement of arterial and venous temperatures are invasive and, for small animal models, are impractical. Here, we present a methodology for the measurement of intravascular and tissue temperature by magnetic resonance imaging (MRI) using the lanthanide agent TmDOTMA(-) (DOTMA, tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; Tm, thulium)...
July 7, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28678610/occupant-responses-in-conventional-and-abts-seats-in-high-speed-rear-sled-tests
#9
David C Viano, Chantal S Parenteau, Roger Burnett, Priya Prasad
OBJECTIVE: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and ABTS (all belts to seat) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. METHODS: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration...
July 5, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28632062/skeleton-sled-velocity-profiles-a-novel-approach-to-understand-critical-aspects-of-the-elite-athletes-start-phases
#10
Steffi L Colyer, Keith A Stokes, James L J Bilzon, Aki I T Salo
The development of velocity across the skeleton start is critical to performance, yet poorly understood. We aimed to understand which components of the sled velocity profile determine performance and how physical abilities influence these components. Thirteen well-trained skeleton athletes (>85% of athletes in the country) performed dry-land push-starts alongside countermovement jump and sprint tests at multiple time-points. A magnet encoder attached to the sled wheel provided velocity profiles, which were characterised using novel performance descriptors...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28632050/effects-of-turf-and-cleat-footwear-on-plantar-load-distributions-in-adolescent-american-football-players-during-resisted-pushing
#11
Jeffrey B Taylor, Anh-Dung Nguyen, Janet R Griffin, Kevin R Ford
Metatarsal and midfoot injuries are common in American football. Footwear design may influence injury rates by altering plantar foot loading patterns in these regions. The purpose of this study was to determine the effect of cleat design on in-shoe plantar foot loading during a football-specific, resisted pushing task. Twenty competitive football players (age 14.7 ± 1.8 years, height 1.72 ± 0.10 m, and mass 71.8 ± 26.9 kg) completed three trials of pushing a weighted sled at maximal effort in a standard shoe (CLEAT) and artificial turf-specific shoe (TURF), with flexible in-shoe force measuring insoles...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28619691/a-mouse-model-of-antepartum-stillbirth
#12
Anum Rahman, Lindsay S Cahill, Yu-Qing Zhou, Johnathan Hoggarth, Monique Y Rennie, Mike Seed, Christopher K Macgowan, John C Kingdom, S Lee Adamson, John G Sled
BACKGROUND: Many stillbirths of normally formed fetuses in the third trimester could be prevented via delivery if reliable means to anticipate this outcome existed. However, because the etiology of these stillbirths is often unexplained and although the underlying mechanism is presumed to be hypoxia from placental insufficiency, the placentas often appear normal on histopathological examination. Gestational age is a risk factor for antepartum stillbirth, with a rapid rise in stillbirth rates after 40 weeks' gestation...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28613265/a-novel-approach-to-measuring-muscle-mechanics-in-vehicle-collision-conditions
#13
Simon Krašna, Srđan Đorđević, Marija Hribernik, Ana Trajkovski
The aim of the study was to evaluate a novel approach to measuring neck muscle load and activity in vehicle collision conditions. A series of sled tests were performed on 10 healthy volunteers at three severity levels to simulate low-severity frontal impacts. Electrical activity-electromyography (EMG)-and muscle mechanical tension was measured bilaterally on the upper trapezius. A novel mechanical contraction (MC) sensor was used to measure the tension on the muscle surface. The neck extensor loads were estimated based on the inverse dynamics approach...
June 14, 2017: Sensors
https://www.readbyqxmd.com/read/28601748/development-of-thoracic-injury-risk-functions-for-the-thor-atd
#14
Gerald S Poplin, Timothy L McMurry, Jason L Forman, Joseph Ash, Daniel P Parent, Matthew J Craig, Eric Song, Richard Kent, Greg Shaw, Jeff Crandall
The Test Device for Human Occupant Restraint (THOR) 50th percentile male anthropomorphic test device (ATD) aims to improve the ability to predict the risk of chest injury to restrained automobile occupants by measuring dynamic chest deflection at multiple locations. This research aimed to describe the methods for developing a thoracic injury risk function (IRF) using the multi-point chest deflection metrics from the 50th percentile male THOR Metric ATD with the SD-3 shoulder and associating to post-mortem human subjects (PMHS) outcomes that were matched on identical frontal and frontal-oblique impact sled testing conditions...
June 8, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28594247/differences-in-the-kinematics-of-booster-seated-pediatric-occupants-using-two-different-car-seats
#15
O Juste-Lorente, M Maza, A I Lorente, F J Lopez-Valdes
OBJECTIVE: The objective of this article is to compare the performance of forward-facing child restraint systems (CRS) mounted on 2 different seats. METHODS: Two different anthropomorphic test device (ATD) sizes (P3 and P6), using the same child restraint system (a non-ISOFIX high-back booster seat), were exposed to the ECE R44 regulatory deceleration pulse in a deceleration sled. Two different seats (seat A, seat B) were used. Three repetitions per ATD and mounting seat were done, resulting in a total of 12 sled crashes...
June 8, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28584428/a-pilot-randomized-controlled-trial-of-comparison-between-extended-daily-hemodialysis-and-continuous-veno-venous-hemodialysis-in-patients-of-acute-kidney-injury-with-septic-shock
#16
Shakti Bedanta Mishra, Afzal Azim, Narayan Prasad, Ratendra Kumar Singh, Banani Poddar, Mohan Gurjar, Arvind Kumar Baronia
AIM OF STUDY: Acute kidney injury (AKI) is common in patients of septic shock. There is sparse data comparing sustained low-efficiency dialysis (SLED) and continuous renal replacement therapy (CRRT) in patients with septic shock. MATERIALS AND METHODS: This is a prospective randomized study in a 12-bedded medical intensive care unit. After clearance from institute's ethics committee and obtaining informed consent from the relatives, sixty adult patients with septic shock who were to undergo dialysis for AKI were included in the study...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28557999/treatment-of-aki-in-developing-and-developed-countries-an-international-survey-of-pediatric-dialysis-modalities
#17
Rupesh Raina, Abigail M Chauvin, Timothy Bunchman, David Askenazi, Akash Deep, Michael J Ensley, Vinod Krishnappa, Sidharth Kumar Sethi
HYPOTHESIS: Acute kidney injury (AKI) is a common cause of morbidity and mortality worldwide, with a pediatric incidence ranging from 19.3% to 24.1%. Treatment of pediatric AKI is a source of debate in varying geographical regions. Currently CRRT is the treatment for pediatric AKI, but limitations due to cost and accessibility force use of adult equipment and other therapeutic options such as peritoneal dialysis (PD) and hemodialysis (HD). It was hypothesized that more cost-effective measures would likely be used in developing countries due to lesser resource availability...
2017: PloS One
https://www.readbyqxmd.com/read/28548611/relationships-between-knee-extension-moments-during-weighted-and-unweighted-gait-and-strength-measures-that-predict-knee-moments-after-acl-reconstruction
#18
Erin Hartigan, Jennifer Aucoin, Rita Carlson, Melanie Klieber-Kusak, Thomas Murray, Bernadette Shaw, Michael Lawrence
BACKGROUND: Weighted gait increases internal knee extension moment impulses (KEMI) in the anterior cruciate ligament-reconstructed (ACLR) limb; however, limb differences persist. HYPOTHESES: (1) KEMI during normal gait will influence KEMI during weighted gait and (2) peak knee extension (PKE) torque and time to reach PKE torque will predict KEMI during gait tasks. STUDY DESIGN: Descriptive laboratory study. METHODS: Twenty-four women and 14 men completed 3 gait tasks (unweighted, vest, sled) and strength testing after discharge from rehabilitation and clearance to return to sports...
July 2017: Sports Health
https://www.readbyqxmd.com/read/28548156/a-field-deployed-surface-plasmon-resonance-spr-sensor-for-rdx-quantification-in-environmental-waters
#19
Thibault Brulé, Geneviève Granger, Natalia Bukar, Clarisse Deschênes-Rancourt, Thierry Havard, Andreea R Schmitzer, Richard Martel, Jean-Francois Masson
A field-deployable surface plasmon resonance (SPR) sensor is reported for the detection of the energetic material (commonly termed explosives) 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) at ppb concentration in environmental samples. The SPR sensor was first validated under laboratory conditions with uncontaminated natural water samples spiked with known concentrations of RDX near the EPA limit of 2 ppb, which was then applied to monitor environmental samples collected in different downgradient wells near a grenade training range...
May 26, 2017: Analyst
https://www.readbyqxmd.com/read/28548153/accelerating-chemical-reactions-by-molecular-sledding
#20
Lei Zhang, Lifei Zheng, Zhuojun Meng, Konstantin Balinin, Mark Loznik, Andreas Herrmann
The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide-porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.
June 8, 2017: Chemical Communications: Chem Comm
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