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https://www.readbyqxmd.com/read/29614970/a-novel-citrate-based-protocol-versus-heparin-anticoagulation-for-sustained-low-efficiency-dialysis-in-the-icu-safety-efficacy-and-cost
#1
Ming Wen, Claudius Küchle, Dominik Steubl, Robin Satanovskji, Uwe Heemann, Yana Suttmann, Susanne Angermann, Stephan Kemmner, Lisa Rehbehn, Monika Huber, Christine Hauser, Christoph Schmaderer, Anna-Lena Reichelt, Bernhard Haller, Lutz Renders
BACKGROUND: The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% citrate solution with common protocol using unfractionated heparin, this study aimed to provide new insights for clinical applications of RCA. METHODS: In this retrospective study, a total of 282 critically ill patients who underwent SLED with citrate and/or heparin anticoagulation in six adult ICUs were enrolled...
April 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29609531/metformin-associated-lactic-acidosis-a-case-series-of-28-patients-treated-with-sustained-low-efficiency-dialysis-sled-and-long-term-follow-up
#2
Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner, Antonello Pani
BACKGROUND: Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant increase in hospitalizations for MALA to our Center. We report the outcomes of our clinical and therapeutic approach. METHODS: This is a single-center case series. Twenty-eight patients affected with MALA and acute kidney failure admitted between January 2000 and September 2014 were included...
April 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29584507/trunk-muscle-recruitment-patterns-in-simulated-precrash-events
#3
Jóna Marín Ólafsdóttir, Jason B Fice, Daniel W H Mang, Karin Brolin, Johan Davidsson, Jean-Sébastien Blouin, Gunter P Siegmund
OBJECTIVES: To quantify trunk muscle activation levels during whole body accelerations that simulate precrash events in multiple directions and to identify recruitment patterns for the development of active human body models. METHODS: Four subjects (1 female, 3 males) were accelerated at 0.55 g (net Δv = 4.0 m/s) in 8 directions while seated on a sled-mounted car seat to simulate a precrash pulse. Electromyographic (EMG) activity in 4 trunk muscles was measured using wire electrodes inserted into the left rectus abdominis, internal oblique, iliocostalis, and multifidus muscles at the L2-L3 level...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584504/top-tether-effectiveness-during-side-impacts
#4
Jordan Majstorovic, Julie Bing, Eric Dahle, John Bolte, Yun-Seok Kang
OBJECTIVE: Few studies have looked at the effectiveness of the top tether during side impacts. In these studies, limited anthropomorphic test device (ATD) data were collected and/or few side impact scenarios were observed. The goal of this study was to further understand the effects of the top tether on ATD responses and child restraint system (CRS) kinematics during various side impact conditions. METHODS: A series of high-speed near-side and far-side sled tests were performed using the FMVSS213 side impact sled buck and Q3s ATD...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584498/the-influence-of-child-restraint-lower-attachment-method-on-protection-offered-by-forward-facing-child-restraint-systems-in-oblique-loading-conditions
#5
Hans W Hauschild, John R Humm, Frank A Pintar, Narayan Yoganandan, Bruce Kaufman, Matthew R Maltese, Kristy B Arbogast
OBJECTIVE: The research objective was to quantify the influence of child restraint lower attachment method on head kinematics, head impact potential, and head, neck, and thorax injury metrics for a child occupant secured in a forward-facing child restraint system (FFCRS) in oblique side impacts. METHODS: Fifteen sled tests were conducted with a Q3s seated in an FFCRS secured to the center position on a production small SUV bench seat. Three lower attachment methods were evaluated: rigid ISOFIX, a flexible single loop lower anchors and tethers for children (LATCH) webbing routed through the vehicle belt path of the FFCRS, and dual flexible LATCH webbing attachments on either side of the FFCRS...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584497/initial-analysis-of-archived-non-human-primate-frontal-and-rear-impact-data-from-the-biodynamics-data-resource
#6
Ardyn V Olszko, Christine M Beltran, Kimberly B Vasquez, James S McGhee, Valeta C Chancey, Narayan Yoganandan, Frank A Pintar, Jamie L Baisden
OBJECTIVE: The research objective was to conduct an initial analysis of non-human primate (NHP) data from frontal and rear impact events archived in the Biodynamics Data Resource (BDR) records of the Naval Biodynamics Laboratory (NBDL). These rare data, collected between 1973 and 1989, will inform the safety community of upper-end tolerance limits of NHP and may be related to severe crash scenarios. METHODS: Data from frontal and rear acceleration tests to 93 macaque NHP were examined...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584494/frontal-and-oblique-crash-tests-of-hiii-6-year-old-child-atd-using-real-world-observed-child-passenger-postures
#7
Katarina Bohman, Kristy B Arbogast, Helen Loeb, Judith L Charlton, Sjaan Koppel, Suzanne L Cross
OBJECTIVE: The aim of this study was to evaluate the consequences of frontal and oblique crashes when positioning a Hybrid III (HIII) 6-year-old child anthropometric test device (ATD) using observed child passenger postures from a naturalistic driving study (NDS). METHODS: Five positions for booster-seated children aged 4-7 years were selected, including one reference position according to the FMVSS 213 ATD seating protocol and 4 based on real-world observed child passenger postures from an NDS including 2 user positions with forward tilting torso and 2 that combined both forward and lateral inboard tilting of the torso...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584475/occupant-kinematics-of-the-hybrid-iii-thor-m-and-postmortem-human-surrogates-under-various-restraint-conditions-in-full-scale-frontal-sled-tests
#8
Devon L Albert, Stephanie M Beeman, Andrew R Kemper
OBJECTIVE: The objective of this research was to compare the occupant kinematics of the Hybrid III (HIII), THOR-M, and postmortem human surrogates (PMHS) during full-scale frontal sled tests under 3 safety restraint conditions: knee bolster (KB), knee bolster and steering wheel airbag (KB/SWAB), and knee bolster airbag and steering wheel airbag (KBAB/SWAB). METHODS: A total of 20 frontal sled tests were performed with at least 2 tests performed per restraint condition per surrogate...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29572954/water-requirements-of-canine-athletes-during-multi-day-exercise
#9
Lara Stephens-Brown, Michael Davis
BACKGROUND: Exercise increases water requirements, but there is little information regarding water loss in dogs performing multi-day exercise OBJECTIVES: Quantify the daily water turnover of working dogs during multi-day exercise and establish the suitability of SC administration of tracer to determine water turnover. ANIMALS: Fifteen privately owned Labrador retrievers trained for explosive detection duties and 16 privately owned Alaskan Huskies conditioned for mid-distance racing...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29570579/moderate-load-resisted-sprints-do-not-improve-subsequent-sprint-performance-in-varsity-level-sprinters
#10
Kyle M A Thompson, Alanna K Whinton, Shane Ferth, Lawrence L Spriet, Jamie F Burr
Resisted sprint training (RST) is commonly used for performance enhancement in athletics and team sports to develop acceleration ability. Evidence suggests that RST may be effective as a short-term intervention to improve successive sprints. While these improvements have been measured in team sport athletes, limited research has considered the acute effects of RST training in sprint-trained athletes. Therefore, the aim of the current study was to determine if performing RST with varsity level sprinters using sled-equivalent resistive loads of ∼45% body mass results in a potentiation effect, leading to improvements in subsequent maximal sprint performance over 0-5 m and 0-20 m...
March 22, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29564759/in-vivo-evaluation-of-the-cardiovascular-system-of-mouse-embryo-and-fetus-using-high-frequency-ultrasound
#11
Yu-Qing Zhou, Lindsay S Cahill, John G Sled
Genetically engineered mice have been widely used for studying cardiovascular development, physiology and diseases. In the past decade, high frequency ultrasound imaging technology has been significantly advanced and applied to observe the cardiovascular structure, function, and blood flow dynamics with high spatial and temporal resolution in mice. This noninvasive imaging approach has made possible longitudinal studies of the mouse embryo/fetus in utero. In this chapter, we describe detailed methods for: (1) the assessment of the structure, function, and flow dynamics of the developing heart of the mouse embryo during middle gestation (E10...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29553802/severe-injury-in-multiple-impacts-analysis-of-1997-2015-nass-cds
#12
David C Viano, Chantal S Parenteau
PURPOSE: This is a descriptive study of the incidence and risk for severe injury in a single impact and multi-impact crashes by belt use and crash type using NASS-CDS. METHODS: 1997-2015 NASS-CDS was used to determine the distribution of crashes by the number of impacts and severe injury (MAIS 4+F) to >15 year old non-ejected drivers by seatbelt use in 1997+ MY vehicles. It compares the risk for severe injury in a single impact and in crashes involving two, three or four+ impacts in the collision with focus on a frontal crash followed by other impacts...
March 19, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29514999/malaria-in-pregnancy-alters-l-arginine-bioavailability-and-placental-vascular-development
#13
Chloe R McDonald, Lindsay S Cahill, Joel R Gamble, Robyn Elphinstone, Lisa M Gazdzinski, Kathleen J Y Zhong, Adrienne C Philson, Mwayiwawo Madanitsa, Linda Kalilani-Phiri, Victor Mwapasa, Feiko O Ter Kuile, John G Sled, Andrea L Conroy, Kevin C Kain
Reducing adverse birth outcomes due to malaria in pregnancy (MIP) is a global health priority. However, there are few safe and effective interventions. l-Arginine is an essential amino acid in pregnancy and an immediate precursor in the biosynthesis of nitric oxide (NO), but there are limited data on the impact of MIP on NO biogenesis. We hypothesized that hypoarginemia contributes to the pathophysiology of MIP and that l-arginine supplementation would improve birth outcomes. In a prospective study of pregnant Malawian women, we show that MIP was associated with lower concentrations of l-arginine and higher concentrations of endogenous inhibitors of NO biosynthesis, asymmetric and symmetric dimethylarginine, which were associated with adverse birth outcomes...
March 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29506150/pharmacokinetics-of-piperacillin-in-critically-ill-patients-with-acute-kidney-injury-receiving-sustained-low-efficiency-diafiltration
#14
Mahipal G Sinnollareddy, Michael S Roberts, Jeffrey Lipman, Sandra L Peake, Jason A Roberts
Background: Piperacillin is a β-lactam penicillin antibiotic commonly used for the empirical therapy of sepsis and other hospital-acquired infections. However, knowledge regarding the effect of sustained low-efficiency diafiltration (SLED-f), a technique increasingly being used in ICUs, on piperacillin pharmacokinetics (PK) and dosing in critically ill patients is lacking. Objectives: To describe the PK of piperacillin during SLED-f and compare the results with those reported for other forms of renal replacement therapies...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29495829/compressed-gas-combined-single-and-two-stage-light-gas-gun
#15
L E Lamberson, P A Boettcher
With more than 1 trillion artificial objects smaller than 1 μm in low and geostationary Earth orbit, space assets are subject to the constant threat of space debris impact. These collisions occur at hypervelocity or speeds greater than 3 km/s. In order to characterize material behavior under this extreme event as well as study next-generation materials for space exploration, this paper presents a unique two-stage light-gas gun capable of replicating hypervelocity impacts. While a limited number of these types of facilities exist, they typically are extremely large and can be costly and dangerous to operate...
February 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29494309/thoracic-and-lumbar-spine-responses-in-high-speed-rear-sled-tests
#16
David C Viano, Chantal S Parenteau, Roger Burnett
OBJECTIVE: This study analyzed thoracic and lumbar spine responses with "in position" and OOP (out-of-position) seated dummies in 40.2 km/h (25 mph) rear sled tests with conventional and ABTS (all belts to seat) seats. Occupant kinematics and spinal responses were determined with modern (≥2000 MY), older (<2000 MY) and ABTS seats. METHODS: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration...
March 1, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29485324/protein-supplementation-during-a-6-month-concurrent-training-program-effect-on-body-composition-and-muscular-strength-in-sedentary-individuals
#17
Michael J Ormsbee, Brandon D Willingham, Tasha Marchant, Teresa L Binkley, Bonny L Specker, Matthew D Vukovich
We examined the effect of a protein supplement on muscular strength and body composition during 6 months of a 5d/wk concurrent strength and endurance training program. Sedentary males (n=26) and females (n=25), 18-25yrs, were randomly assigned to receive a protein (PRO, 42g/serving) or carbohydrate (CON) supplement twice daily. Strength and body composition (DXA) were assessed at baseline, 3(3M) and 6(6M) months. Protein intake was higher in PRO [PRO:2.2g/kg; CON:1.1g/kg, P<0.001]. Females in both groups gained similar strength at 3M and 6M in bench press (BP) and hip sled (HS)...
February 27, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29394441/biofidelity-evaluation-of-the-thor-and-hybrid-iii-50th-percentile-male-frontal-impact-anthropomorphic-test-devices
#18
Daniel Parent, Matthew Craig, Kevin Moorhouse
The objective of this study is to present a quantitative comparison of the biofidelity of the THOR and Hybrid III 50th percentile male ATDs. Quantitative biofidelity was assessed using NHTSA's Biofidelity Ranking System in a total of 21 test conditions, including impacts to the head, face, neck, upper thorax, lower oblique thorax, upper abdomen, lower abdomen, femur, knee, lower leg, and whole-body sled tests to evaluate upper body kinematics and thoracic response under frontal and frontal oblique restraint loading...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29394436/optimizing-seat-belt-and-airbag-designs-for-rear-seat-occupant-protection-in-frontal-crashes
#19
Jingwen Hu, Matthew P Reed, Jonathan D Rupp, Kurt Fischer, Paul Lange, Angelo Adler
Recent field data have shown that the occupant protection in vehicle rear seats failed to keep pace with advances in the front seats likely due to the lack of advanced safety technologies. The objective of this study was to optimize advanced restraint systems for protecting rear seat occupants with a range of body sizes under different frontal crash pulses. Three series of sled tests (baseline tests, advanced restraint trial tests, and final tests), MADYMO model validations against a subset of the sled tests, and design optimizations using the validated models were conducted to investigate rear seat occupant protection with 4 Anthropomorphic Test Devices (ATDs) and 2 crash pulses...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29382394/pharmacokinetics-of-meropenem-in-septic-patients-on-sustained-low-efficiency-dialysis-a-population-pharmacokinetic-study
#20
Stephan Braune, Christina König, Jason A Roberts, Axel Nierhaus, Oliver Steinmetz, Michael Baehr, Stefan Kluge, Claudia Langebrake
BACKGROUND: The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED). METHODS: Prospective population PK study on 19 septic patients treated with meropenem and receiving SLED for acute kidney injury. Serial blood samples for determination of meropenem concentrations were taken before, during and after SLED in up to three sessions per patient. Nonparametric population PK analysis with Monte Carlo simulations were used...
January 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
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