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Matthew W Brunke, Christopher W Frye, Corri B Levine, Cristina Hansen, Joseph J Wakshlag
The objective of this study was to investigate the effects of running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins 1 and 3 (IGFBP-1 and IGFBP-3). Serum was examined from 12 sled dogs prior to the race, at midrace (approximately 690 km), and again at the finish. IGF-1, IGFBP-1, and IGFBP-3 were assessed using radioimmunoassay or enzyme linked immune-absorbance assays. Mean prerace concentrations were significantly higher than midrace and end-race concentrations at 215...
2016: TheScientificWorldJournal
Adrienne Dorr, Lynsie Am Thomason, Margaret M Koletar, Illsung L Joo, Joe Steinman, Lindsay S Cahill, John G Sled, Bojana Stefanovic
Aerobic activity has been shown highly beneficial to brain health, yet much uncertainty still surrounds the effects of exercise on the functioning of cerebral microvasculature. This study used two-photon fluorescence microscopy to examine cerebral hemodynamic alterations as well as accompanying geometric changes in the cortical microvascular network following five weeks of voluntary exercise in transgenic mice endogenously expressing tdTomato in vascular endothelial cells to allow visualization of microvessels irrespective of their perfusion levels...
September 28, 2016: Journal of Cerebral Blood Flow and Metabolism
J Lim, P Muthusami, S Madathil, M Zhu, B S Saini, P Porayette, V Chau, S Portnoy, C Macgowan, J G Sled, J C Kingdom, M Seed, S Miller
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
A Duan, M Zhu, S Portnoy, N Milligan, J Lim, J Keunen, C Macgowan, J G Sled, J C Kingdom, M Seed
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
A Duan, J Keunen, S Portnoy, M Zhu, C Anastasiadis, G Ryan, P Porayette, B Saini, J G Sled, C Macgowan, M Seed
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
L Sun, B Saini, P Porayette, C Macgowan, J Sled, S Yoo, L Grosse-Wortmann, E Jaeggi, B McCrindle, J C Kingdom, E Hickey, S Miller, M Seed
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Julia M Young, Benjamin R Morgan, Hilary E A Whyte, Wayne Lee, Mary Lou Smith, Charles Raybaud, Manohar M Shroff, John G Sled, Margot J Taylor
Identifying trajectories of early white matter development is important for understanding atypical brain development and impaired functional outcomes in children born very preterm (<32 weeks gestational age [GA]). In this study, 161 diffusion images were acquired in children born very preterm (median GA: 29 weeks) shortly following birth (75), term-equivalent (39), 2 years (18), and 4 years of age (29). Diffusion tensors were computed to obtain measures of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), which were aligned and averaged...
September 6, 2016: Cerebral Cortex
F Auriault, L Thollon, J Pérès, M Behr
This study documents the development of adverse fetal outcome predictors dedicated to the analysis of road accidents involving pregnant women. To do so, a pre-existing whole body finite element model representative of a 50th percentile 26 weeks pregnant woman was used. A total of 8 accident scenarios were simulated with the model positioned on a sled. Each of these scenarios was associated to a risk of adverse fetal outcome based on results from real car crash investigations involving pregnant women from the literature...
September 2, 2016: Accident; Analysis and Prevention
Hans W Hauschild, John R Humm, Frank A Pintar, Narayan Yoganandan, Bruce Kaufman, Jinyong Kim, Matthew R Maltese, Kristy B Arbogast
OBJECTIVE: Testing was conducted to quantify the kinematics, potential for head impact, and influence on head injury metrics for a center-seated Q3s in a forward-facing child restraint system (FFCRS) in oblique impacts. The influences of a tether and intruded door on these measures were explored. METHODS: Nine lateral oblique sled tests were conducted on a convertible forward-facing child restraint seat (FFCRS). The FFCRSs were secured to a bench seat from a popular production small SUV at the center seating position utilizing the lower anchor and tether for children (LATCH)...
September 2016: Traffic Injury Prevention
Stephanie M Beeman, Andrew R Kemper, Stefan M Duma
OBJECTIVE: The objective of this study was to quantify the effects of active muscles (e.g. conscious bracing, resting tone, and reflex response) and acceleration severity on the neck forces and moments generated during low-speed frontal sled tests with adult male human volunteers and post mortem human surrogates (PMHSs). METHODS: A total of 24 frontal sled tests were analyzed including male volunteers of approximately 50th percentile height and weight (n = 5) and PMHSs (n = 2)...
September 2016: Traffic Injury Prevention
Andrew R Kemper, Stephanie M Beeman, David J Porta, Stefan M Duma
OBJECTIVE: The purpose of this study was to obtain non-censored rib fracture data due to three-point belt loading during dynamic frontal post-mortem human surrogate (PMHS) sled tests. The PMHS responses were then compared to matched tests performed using the Hybrid-III 50(th) percentile male ATD. METHODS: Matched dynamic frontal sled tests were performed on two male PMHSs, which were approximately 50(th) percentile height and weight, and the Hybrid-III 50(th) percentile male ATD...
September 2016: Traffic Injury Prevention
Bengt Pipkorn, Francisco J López-Valdés, Oscar Juste-Lorente, Ricardo Insausti, Christer Lundgren, Cecilia Sunnevång
OBJECTIVES: The objective of this study was to determine the potential chest injury benefits and influence on occupant kinematics of a belt system with independent control of the shoulder and lap portions. METHODS: This article investigates the kinematics and dynamics of human surrogates in 35 km/h impacts with 2 different restraints: a pretensioning (PT), force-limiting (FL) seat belt, a reference belt system, and a concept design with a split buckle consisting (SB) of 2 separate shoulder and lap belt bands...
September 2016: Traffic Injury Prevention
Mike W J Arun, Sagar Umale, John R Humm, Narayan Yoganandan, Prasanaah Hadagali, Frank A Pintar
OBJECTIVE: The objective of the current study was to perform a parametric study with different impact objects, impact locations, and impact speeds by analyzing occupant kinematics and injury estimations using a whole-vehicle and whole-body finite element-human body model (FE-HBM). To confirm the HBM responses, the biofidelity of the model was validated using data from postmortem human surrogate (PMHS) sled tests. METHODS: The biofidelity of the model was validated using data from sled experiments and correlational analysis (CORA)...
September 2016: Traffic Injury Prevention
Bingbing Nie, Jason L Forman, Hamed Joodaki, Taotao Wu, Richard W Kent
OBJECTIVE: Occupants with extreme body size and shape, such as the small female or the obese, were reported to sustain high risk of injury in motor vehicle crashes (MVCs). Dimensional scaling approaches are widely used in injury biomechanics research based on the assumption of geometrical similarity. However, its application scope has not been quantified ever since. The objective of this study is to demonstrate the valid range of scaling approaches in predicting the impact response of the occupants with focus on the vulnerable populations...
September 2016: Traffic Injury Prevention
Fusako Sato, Mamiko Odani, Yusuke Miyazaki, Kunio Yamazaki, Jonas Östh, Mats Svensson
OBJECTIVE: The aim of this study was to investigate the whole spine alignment in automotive seated postures for both genders and effects of the spinal alignment patterns on cervical vertebral motion in rear impact using a human Finite Element (FE) model. METHODS: Image data of 8 female and 7 male subjects in a seated posture acquired by an upright open MRI system were utilized. Spinal alignment was determined from the centers of the vertebrae and average spinal alignment patterns for both genders were estimated by Multi Dimensional Scaling (MDS)...
August 30, 2016: Traffic Injury Prevention
Robert D Vincent, Peter Neelin, Najmeh Khalili-Mahani, Andrew L Janke, Vladimir S Fonov, Steven M Robbins, Leila Baghdadi, Jason Lerch, John G Sled, Reza Adalat, David MacDonald, Alex P Zijdenbos, D Louis Collins, Alan C Evans
It is often useful that an imaging data format can afford rich metadata, be flexible, scale to very large file sizes, support multi-modal data, and have strong inbuilt mechanisms for data provenance. Beginning in 1992, MINC was developed as a system for flexible, self-documenting representation of neuroscientific imaging data with arbitrary orientation and dimensionality. The MINC system incorporates three broad components: a file format specification, a programming library, and a growing set of tools. In the early 2000's the MINC developers created MINC 2...
2016: Frontiers in Neuroinformatics
Sérgio Aparecido Cleto, Camila Eleutério Rodrigues, Ceila Maria Malaque, Jaques Sztajnbok, Antônio Carlos Seguro, Lúcia Andrade
BACKGROUND: Leptospirosis is a health problem worldwide. Its most severe form is a classic model of sepsis, provoking acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI), with associated mortality that remains unacceptably high. We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. However, the mode of clearance can also affect dialysis patient outcomes. Therefore, the objective of this study was to compare the effects of SLED with traditional (diffusive) clearance, via hemodialysis, and SLED with convective clearance, via hemodiafiltration (SLEDf), in patients with severe leptospirosis...
2016: PloS One
Bart Johnson, Walid Atia, Dale C Flanders, Mark Kuznetsov, Brian D Goldberg, Nate Kemp, Peter Whitney
A back-to-back comparison of a tunable narrow-band-filtered SLED (TSLED) and a swept laser are made for OCT applications. The two sources are similar in terms of sweep speed, tuning range and coherence length. A fundamental issue with a TSLED is that the RIN is proportional to 1/linewidth, meaning that the longer the coherence length, the higher the RIN and clock jitter. We show that the TSLED has an SNR limit that causes noise streaks at points of high reflection in images. The laser, which is shot noise limited, does not exhibit this effect...
May 16, 2016: Optics Express
Anand Kaul, Ahmed Abbas, Gabriel Smith, Sunil Manjila, Jonathan Pace, Michael Steinmetz
Fatal craniovertebral junction (CVJ) injuries were the most common cause of death in high-speed motor sports prior to 2001. Following the death of a mutual friend and race car driver, Patrick Jacquemart (1946-1981), biomechanical engineer Dr. Robert Hubbard, along with race car driver and brother-in-law Jim Downing, developed the concept for the Head and Neck Support (HANS) device to prevent flexion-distraction injuries during high-velocity impact. Biomechanical testing showed that neck shear and loading forces experienced during collisions were 3 times the required amount for a catastrophic injury...
July 12, 2016: Journal of Neurosurgery. Spine
Peter F Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Winter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency departments (EDs). METHODS: The National Electronic Injury Surveillance System (NEISS), a population-based resource, was evaluated for ED visits from 2010 to 2014 for children injured from "active" winter -undertakings (snowboarding, skiing, ice skating) and sledding/tubing...
August 2016: International Journal of Pediatric Otorhinolaryngology
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