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https://www.readbyqxmd.com/read/28438013/characterization-of-newly-bred-cordyceps-militaris-strains-for-higher-production-of-cordycepin-through-hplc-and-urp-pcr-analysis
#1
Hyun-Hee Lee, Naru Kang, Inmyoung Park, Jungwook Park, Inyoung Kim, Jieun Kim, Namgyu Kim, Jae-Yun Lee, Young-Su Seo
Cordyceps militaris, a member of Ascomycota, a mushroom referred to as caterpillar Dong-chung-ha-cho, is commercially valuable because of its high content of bioactive substances including cordycepin and its potential for artificial cultivation. Cordycepin (3'-deoxyadenosine) is highly associated with the pharmacological effects of C. militaris. C. militaris is heterothallic in that two mating type loci, idiomorph MAT1-1 and MAT1-2, exist discretely in two different spores. In this study, nine C. militaris strains were mated with each other to prepare new strains that produced a larger amount of cordycepin than the parent strains...
April 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28437945/experimental-demonstration-of-wideband-multimodule-serial-reflectors
#2
Yeong Hwan Ko, Kyu Jin Lee, Robert Magnusson
We demonstrate unpolarized wideband reflectors fashioned with orthogonal serial resonant reflectors. Unpolarized incident light generates internal TM- and TE-polarized reflections that are made to cooperate to extend the bandwidth of the composite spectral reflectance. The experimental results presented show ~42% band extension by a two-grating module. In addition, good angular tolerance is found because the orthogonal arrangement simultaneously supports classical and fully conic mountings at oblique angles...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437934/dual-channel-multilayer-coated-surface-plasmon-resonance-sensor-for-dual-refractive-index-range-measurements
#3
Mengdi Lu, Wei Peng, Qiang Liu, Yun Liu, Lixia Li, Yuzhang Liang, Jean-Francois Masson
We present a novel multilayer-coated surface plasmon resonance sensor for dual refractive index range measurements based on a capillary structure. The sensing elements include an internally coated Ag layer and an externally coated bilayer of Au with an overlayer of thin indium tin oxide (ITO). The internal Ag layer was sensitive to higher refractive index (RI) medium while the external Au/ITO layer was sensitive to lower refractive index medium. We evaluated the sensor performance by measuring RI changes in two channels, RI sensitivities were -1951 nm/RIU and 2496 nm/RIU, respectively...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437930/si-traceable-measurement-of-an-optical-frequency-at-the-low-10-sup-16-sup-level-without-a-local-primary-standard
#4
Hidekazu Hachisu, Gérard Petit, Fumimaru Nakagawa, Yuko Hanado, Tetsuya Ido
SI-traceable measurements of optical frequencies using International Atomic Time (TAI) do not require a local primary frequency reference, but suffer from an uncertainty in tracing to the SI second. For the measurement of the <sup>87</sup>Sr lattice clock transition, we have reduced this uncertainty to the low 10<sup>-16</sup> level by averaging three sets of ten-day intermittent measurements, in which we operated the lattice clock for 10<sup>4</sup> s on each day. Moreover, a combined oscillator of two hydrogen masers was employed as a local flywheel oscillator (LFO) in order to mitigate the impact of sporadic excursion of LFO frequency...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437926/demonstration-of-a-dual-mode-si-detector-as-a-self-calibrating-device-at-room-temperature
#5
Marit Ulset Nordsveen, Chi Kwong Tang, Jarle Gran
We demonstrate the use of a dual-mode detector for determining the internal quantum deficiency of a silicon photodiode without the use of an external reference. This is achieved by combining two different principles for measuring optical power in one device, where the photodiode is used as absorber for both thermal and photon detection. Thermal detection is obtained by the same principle as for an electrical substitution radiometer (ESR), with a type A measurement uncertainty of 0.34 % in unstabilized room temperature...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437923/nanoparticle-crystal-towards-an-absorbing-meta-coating
#6
Zi-Xun Jia, Yong Shuai, Yan-Ming Guo, He-Ping Tan
In this paper, a double layer nanoparticle-crystal has been proposed, which shown incident and polarization angle, substrate independences for spectral absorptivity. Such phenomenon originates from the near-field light redistribution and excitation of internal collective oscillating. This kind of nanoparticle-crystal can be made of various types of metal with similar optical responses. A three oscillators mode has been proposed in this paper to understand the shift between global and internal collective oscillating, and verify the physical picture demonstrated...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437894/effect-of-anisotropic-electron-momentum-distribution-of-surface-plasmon-on-internal-photoemission-of-a-schottky-hot-carrier-device
#7
Xin-Hao Li, Jeffrey B Chou, Wei Lek Kwan, Asma M Elsharif, Sang-Gook Kim
We recently reported that an Au/TiO<sub>2</sub> photonic crystal device for photochemical energy conversion showed a sub-bandgap photoresponse centered at the surface plasmon polariton (SPP) resonant wavelength of this device. Here we developed a theoretical modeling of the internal photoemission in this device by incorporating the effects of anisotropic hot electron momentum distribution caused by SPP. The influences of interband and intraband transition, anisotropic momentum distribution of hot electrons by SPP are integrated to model the internal quantum efficiency (IQE) of this device...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437818/-towards-a-rehabilitation-and-participation-oriented-psychotherapy
#8
Beate Muschalla, Jürgen Bengel, Matthias Morfeld, Ulrike Worringen
Mental disorders (such as recurrent mood disorders, personality disorders, or psychotic disorders) come along with enduring impairment in daily life activities. Therefore psychotherapeutic actions in inpatient or outpatient settings require a life-span and participation-oriented treatment perspective. Participation-oriented treatment aims at social and vocational integration in general life despite enduringly recurring or resting symptoms. According to the model of health problems offered by the International Classification of Functioning, Disability and Health, ICF (WHO, 2001), disability can be defined as context-dependent activity impairment due to illness...
April 24, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28437764/the-use-of-lithium-for-the-treatment-of-bipolar-disorder-recommendations-from-clinical-practice-guidelines
#9
Gin S Malhi, Danielle Gessler, Tim Outhred
BACKGROUND: Lithium is an effective mood stabilizer that is used principally for the management of bipolar disorder (BD). Its administration is complex and often requires sophisticated management and assiduous monitoring. When considering the use of lithium therapy for bipolar disorder, clinicians are advised to refer to recommendations outlined in clinical practice guidelines (CPGs); but because of varying emphases placed by different international CPGs, recommendations addressing the practical use of lithium lack consistency...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28437733/the-establishment-of-in%C3%A2-vitro-culture-and-drug-screening-systems-for-a-newly-isolated-strain-of-trypanosoma-equiperdum
#10
Keisuke Suganuma, Shino Yamasaki, Nthatisi Innocentia Molefe, Peter Simon Musinguzi, Batdorj Davaasuren, Ehab Mossaad, Sandagdorj Narantsatsral, Banzragch Battur, Badgar Battsetseg, Noboru Inoue
Dourine is caused by Trypanosoma equiperdum via coitus with an infected horse. Although dourine is distributed in Equidae worldwide and is listed as an internationally important animal disease by the World Organization for Animal Health (OIE), no effective treatment strategies have been established. In addition, there are no reports on drug discovery, because no drug screening system exists for this parasite. A new T. equiperdum strain was recently isolated from the genital organ of a stallion that showed typical symptoms of dourine...
April 13, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28437723/clinical-course-and-disease-burden-in-patients-with-paroxysmal-nocturnal-hemoglobinuria-by-hemolytic-status
#11
Mustafa N Yenerel, Petra Muus, Amanda Wilson, Jeff Szer
Disease characteristics of patients enrolled in the International PNH Registry were assessed during two follow-up periods based on hemolytic status while untreated with eculizumab: Non-hemolytic cohort: follow-up time defined as time from disease start until last reported untreated lactate dehydrogenase (LDH) value <1.5×upper limit normal (ULN); Hemolytic cohort: follow-up time defined as time from LDH ≥1.5×ULN at or post-disease start, to most recent untreated follow-up. A total of 1012 patients met criteria for the Non-hemolytic cohort and 1565 patients for the Hemolytic cohort; median (min, max) years of follow-up were 2...
March 27, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28437720/determination-of-a-novel-anticancer-ampk-activator-hernandezine-in-rat-plasma-and-tissues-with-a-validated-uhplc-ms-ms-method-application-to-pharmacokinetics-and-tissue-distribution-study
#12
Yang Song, Zhibin Wang, Baozhen Zhang, Yujia Zhang, Weipeng Zhang, Chunjuan Yang, Fanhao Meng, Xuesong Feng
Hernandezine, a novel anticancer AMPK activator, is a major active constituent of Thalictrum Ranunculaceae. A simple, specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of hernandezine in rat plasma and tissues after intravenous administration. Sample preparation was carried out through a protein-precipitation extraction with acetonitrile using tetrandrine as internal standard (IS). The chromatographic separation was achieved by using an Agilent ZORBAX Eclipse Plus C18 column with a mobile phase of acetonitrile and water (containing 10mM ammonium acetate) in an isocratic elution way...
April 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28437691/midwifery-participatory-curriculum-development-transformation-through-active-partnership
#13
Mary Sidebotham, Caroline Walters, Janine Chipperfield, Jenny Gamble
Evolving knowledge and professional practice combined with advances in pedagogy and learning technology create challenges for accredited professional programs. Internationally a sparsity of literature exists around curriculum development for professional programs responsive to regulatory and societal drivers. This paper evaluates a participatory curriculum development framework, adapted from the community development sector, to determine its applicability to promote engagement and ownership during the development of a Bachelor of Midwifery curriculum at an Australian University...
April 15, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#14
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437619/management-of-posterior-cruciate-ligament-tibial-avulsion-injuries-a-systematic-review
#15
Perry O Hooper, Chris Silko, Tennison L Malcolm, Lutul D Farrow
BACKGROUND: Tibial-sided avulsion injuries of the posterior cruciate ligament (PCL) generally require surgical intervention. No consensus exists concerning the optimal surgical treatment approach for these injuries. PURPOSE: To perform a systematic review investigating the open and arthroscopic surgical treatment modalities, outcomes, and complications of PCL tibial-sided bony avulsions. STUDY DESIGN: Systematic review; Level of evidence, 4...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28437618/state-of-the-art-calculations-of-sublimation-enthalpies-for-selected-molecular-crystals-and-their-computational-uncertainty
#16
Ctirad Červinka, Michal Fulem
A computational methodology for calculation of sublimation enthalpies of molecular crystals from first principles is developed and validated by comparison to critically evaluated literature experimental data. Temperature dependent sublimation enthalpies for a set of selected 22 molecular crystals in their low-temperature phases are calculated. The computational methodology consists in several building blocks based on high level electronic structure methods of quantum chemistry and statistical thermodynamics...
April 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28437600/how-are-behavioral-theories-used-in-interventions-to-promote-physical-activity-in-rheumatoid-arthritis-a-systematic-review
#17
Ingrid Demmelmaier, Maura D Iversen
OBJECTIVES: To identify the use of behavioral theories (BTs) in physical activity (PA) interventions in populations with RA. METHODS: This review includes articles published in English between 01-01-1980 and 08-12-2015 in MEDLINE, Cochrane and CINAHL identified by a strategic literature search. Included studies were: published in international peer-reviewed journals; mentioned "theory", evaluated a PA intervention for adults with RA; and had ≥ 1 PA variable as the outcome...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437595/natural-history-and-predictors-of-progression-to-sj%C3%A3-gren-s-syndrome-among-participants-of-the-sicca-registry
#18
Caroline H Shiboski, Alan N Baer, Stephen C Shiboski, Mi Lam, Stephen Challacombe, Hector E Lanfranchi, Morten Schiødt, Penelope Shirlaw, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Esen Akpek, Vatinee Bunya, Cristina F Vollenweider, John S Greenspan, Troy E Daniels, Lindsey A Criswell
BACKGROUND/PURPOSE: To explore changes in the phenotypic features of Sjoögren's syndrome (SS), and in SS status among participants in the Sjoögren's International Collaborative Clinical Alliance (SICCA) registry over a 2 to 3-year interval. METHODS: All participants in the SICCA registry who were found to have any objective measures of salivary hypofunction, dry eye, focal lymphocytic sialadenitis in minor salivary gland biopsy, or anti-SSA/B antibodies, were recalled over a window of 2 to 3 years after their baseline examinations to repeat all clinical examinations and specimen collections to determine whether there was any change in phenotypic features and in SS status...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437573/using-internal-and-external-reviewers-can-help-to-optimise-neonatal-mortality-and-morbidity-conferences
#19
Michael-Andrew Assaad, Annie Janvier, Anie Lapointe
AIM: This study determined if there was a difference in the conclusions reached by paediatricians in morbidity and mortality conferences based on their level of involvement in a case. METHODS: All neonatal deaths occurring between August 2014 and September 2015 at Sainte-Justine Hospital, Montreal, Quebec, Canada, were reviewed by internal physicians involved in the case and external physicians who were not. The reviewers were asked to identify positive and negative clinical practice items and provide written recommendations...
April 24, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28437571/label-free-high-temporal-resolution-assessment-of-cell-proliferation-using-digital-holographic-microscopy
#20
Birgit Janicke, Andreas Kårsnäs, Peter Egelberg, Kersti Alm
Cell proliferation assays are widely applied in biological sciences to understand the effect of drugs over time. However, current methods often assess cell population growth indirectly, that is, the cells are not actually counted. Instead other parameters, for example, the amount of protein, are determined. These methods often also demand phototoxic labels, have low temporal resolution, or employ end-point assays, and frequently are labor intensive. We have developed a robust and label-free kinetic cell proliferation assay with high temporal resolution for adherent cells using digital holographic microscopy (DHM), one of many quantitative phase microscopy techniques...
April 24, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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