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https://www.readbyqxmd.com/read/29239678/the-effect-of-antibiotic-prophylaxis-for-acute-pelvic-inflammatory-disease-after-hysterosalpingography-a-retrospective-cohort-study
#1
Hao-Ming Li, Fung-Chang Sung, Shang-Chieh Li, Ying-Kai Huang, Yu Chang, Chi-Chang Chang, S Joseph Huang, Cheng-Li Lin, Chia-Hung Kao
AIMS: The concern about acute pelvic inflammatory disease (PID) after hysterosalpingography (HSG) has been raised since 1980. However, the effectiveness of prophylactic antibiotics remains unclear. This study investigated the effect of antibiotic prophylaxis in women undergoing HSG. METHODS: Women undergoing HSG between 2000 and 2012 were screened from Taiwan National Health Insurance Research Database for eligibility. The prophylactic cohort included patients using any antibiotics of 1st-generation cephalosporins, doxycycline, clindamycin, and metronidazole, within seven days before HSG (N = 3257)...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29236898/in-vitro-analysis-of-a-local-polymeric-device-as-an-alternative-for-systemic-antibiotics-in-dentistry
#2
Talita Girio Carnaval, Flávia Gonçalves, Marcelo Munhóes Romano, Luiz Henrique Catalani, Marcia Alves Pinto Mayer, Victor Elias Arana-Chávez, Alexander Cassandri Nishida, Thais Claudino Lage, Carlos Eduardo Francci, Carlos Alberto Adde
The development of a biodegradable material with antimicrobial properties for local applications is required in the prevention and treatment of infectious diseases. The objective of this study was to produce blends of poly-L-lactide acid (PLLA) synthetic polymer associated with several antimicrobials, as an alternative in the prevention and treatment of infections, as well as to evaluate its cytotoxicity, release of antimicrobials and inhibit bacteria growth. Blends of PLLA added with 20% Amoxicillin, Metronidazole, Clindamycin or Azithromicyn were used to produce Films (F) or Meshs (M) by casting and electrospinning methods, respectively...
December 7, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29235736/primary-and-secondary-antibiotic-resistance-of-helicobacter-pylori-in-israeli-children-and-adolescents
#3
Michal Kori, Jacob Yahav, Rita Berdinstein, Haim Shmuely
BACKGROUND: Empiric treatment for Helicobacter pylori is influenced by antibiotic susceptibility of infecting strains. A rise in the resistance rate to clarithromycin and metronidazole has been reported in pediatric populations. OBJECTIVES: To assess the primary and secondary antibiotic resistance of H. pylori isolates in Israeli children and adolescents. METHODS: A retrospective review of H. pylori isolates cultured from antral biopsies of consecutive children aged 1 to 18 years, who were referred to the Pediatric Gastroenterology Unit, Kaplan Medical Center, over a 2...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29227855/a-case-report-of-successful-management-of-clostridium-difficile-colitis-with-antegrade-fidaxomicin-through-a-mucous-fistula-obviating-the-need-for-subtotal-colectomy
#4
Suzanne Arnott, Matthew Skancke, Sheena Chen, Bruce Abell
INTRODUCTION: Clostridium difficile is the most common cause of healthcare-associated infections and can have devastating morbidity and mortality. Traditional treatment algorithms involve intravenous metronidazole and enteric metronidazole or vancomycin. Fidaxomicin (DificidR) targets "switch regions" within RNA polymerases and effectively kills clostridium difficile bacteria and is typically administered orally primarily or through a naso/oro-gastric conduit. PRESENTATION OF CASE: 55-year-old with a recent elective surgical procedure was hospitalized with multifocal pneumonia and subsequently developed clostridium difficile colitis...
November 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227738/antibiotic-resistance-of-helicobacter-pylori-in-iranian-children-a-systematic-review-and-meta-analysis
#5
Arshid Yousefi-Avarvand, Hamid Vaez, Mohsen Tafaghodi, Amir Hossein Sahebkar, Mohsen Arzanlou, Farzad Khademi
Antibiotic therapy for children infected with Helicobacter pylori is important. However, resistance to antibiotics is one of the main causes of treatment failure. This study was designed to evaluate the prevalence pattern of antibiotic resistance of H. pylori in Iranian children using a systematic review and meta-analysis of literature. A computerized search (until June 10, 2017) using related keywords in the national and international databases was performed. A total of 261 original articles on antibiotic resistance of H...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227201/early-rescue-from-acute-severe-clostridium-difficile-a-novel-treatment-strategy
#6
Biniam Kidane, Kalvin Lung, Greig McCreery, Chadia El-Khatib, Michael C Ott, Roberto Hernandez-Alejandro, Chris Vinden, Daryl Gray, Neil G Parry, Kenneth A Leslie, Tina S Mele
BACKGROUND: Severe Clostridium difficile infections (CDI) can lead to significant impediments to effective treatment. We developed a novel treatment protocol utilizing bedside gastrointestinal lavage (GIL) for the management of patients with severe, complicated CDI. We describe the development and early outcomes of non-operative bedside GIL in hospitalized patients with severe, complicated CDI following the Idea, Development, Exploration, Assessment, Long Term Study (IDEAL) framework at the Idea stage...
December 11, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29222426/surveillance-of-antibiotic-resistance-among-common-clostridium-difficile-ribotypes-in-hong-kong
#7
Viola C Y Chow, Thomas N Y Kwong, Erica W M So, Yolanda I I Ho, Sunny H Wong, Raymond W M Lai, Raphael C Y Chan
Incidence of Clostridium difficile infection (CDI) is rapidly increasing and it poses a major health burden globally. However, data regarding the epidemiology of CDI in Asia are limited. We aimed to characterize the antimicrobial susceptibility patterns of common ribotypes of toxigenic C. difficile in Hong Kong. Fifty-three PCR ribotypes were identified among 284 toxigenic C. difficile clinical isolates. The five most prevalent ribotypes were 002 (13%), 017 (12%), 014 (10%), 012 (9.2%), and 020 (9.5%). All tested C...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221614/using-amoxicillin-plus-metronidazole-as-an-adjunct-to-nonsurgical-periodontal-treatment-results-in-little-benefit-and-there-seems-to-be-no-difference-among-regimens
#8
Romina Brignardello-Petersen
No abstract text is available yet for this article.
December 2, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29219812/helicobacter-pylori-resistance-in-the-netherlands-a-growing-problem
#9
R Ruiter, H F Wunderink, R A Veenendaal, L G Visser, M G J de Boer
Helicobacter pylori infection is clinically associated with dyspepsia, gastric and duodenal ulcers, and gastric cancer. Increasing antimicrobial resistance in H. pylori is a worldwide problem and failure of eradication with standard triple therapy (high-dose proton pump inhibition, amoxicillin and clarithromycin) is directly related to the presence of a resistant strain. Other treatment combinations have been investigated, but with inconsistent results. Based on a review of the recent literature in conjunction with an analysis of the regional resistance data, we address the increasing complexity of H...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218061/a-comparative-study-of-efficacy-and-safety-of-two-eradication-regimens-for-helicobacter-pylori-infection
#10
Carmen Monica Preda, Doina Proca, Irina Sandra, Larisa Elena Fulger, Boroka Claudia Horeanga, Mircea Manuc, Teodora Manuc, Catalin Andrei Dutei, Mihaela Barbu, Letitia Tugui, Adriana-Corina Andrei, Bogdan Ionut Slavulete, Mircea Diculescu
Introduction: Helicobacter pylori infection is one of the most frequent diseases around the world, affecting about half of the world population. The infection is known to be associated with upper gastrointestinal diseases. The aim of this paper is to identify which of the following two first-line therapy options (ECA vs ECM - see abbreviations below) is more efficient and to assess the improvement in the quality of life among these patients. Material and Methods: 96 patients with proven Helicobacter pylori infection were divided in two treatment groups, as follows: 47 patients received a 10-day triple therapy with esomeprazole 80 mg/day, amoxicillin 2000 mg/day and clarithromycin 1000 mg/day (ECA) and the rest of 49 received a 10-day sequential therapy: esomeprazole 40 mg and amoxicillin 1000 mg twice daily for five days, followed by esomeprazole 40 mg, clarithromycin 500 mg and metronidazole 500 mg (ECM) twice daily for another five days...
September 2017: Mædica
https://www.readbyqxmd.com/read/29216899/generic-reference-and-generic-generic-bioequivalence-of-forty-two-randomly-selected-on-market-generic-products-of-fourteen-immediate-release-oral-drugs
#11
Muhammad M Hammami, Sophia J S De Padua, Rajaa Hussein, Eman Al Gaai, Nesrine A Khodr, Reem Al-Swayeh, Syed N Alvi, Nada Binhashim
BACKGROUND: The extents of generic-reference and generic-generic average bioequivalence and intra-subject variation of on-market drug products have not been prospectively studied on a large scale. METHODS: We assessed bioequivalence of 42 generic products of 14 immediate-release oral drugs with the highest number of generic products on the Saudi market. We conducted 14 four-sequence, randomized, crossover studies on the reference and three randomly-selected generic products of amlodipine, amoxicillin, atenolol, cephalexin, ciprofloxacin, clarithromycin, diclofenac, ibuprofen, fluconazole, metformin, metronidazole, paracetamol, omeprazole, and ranitidine...
December 8, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29216562/substituted-carbamothioic-amine-1-carbothioic-thioanhydrides-as-novel-trichomonicidal-fungicides-design-synthesis-and-biology
#12
Dhanaraju Mandalapu, Bhavana Kushwaha, Sonal Gupta, Shagun Krishna, Nidhi Srivastava, Mahendra Shukla, Pratiksha Singh, Bhavana S Chauhan, Ravi Goyani, Jagdamba P Maikhuri, Koneni V Sashidhara, Brijesh Kumar, Renu Tripathi, Praveen K Shukla, Mohammad I Siddiqi, Jawahar Lal, Gopal Gupta, Vishnu L Sharma
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic amine-1-carbothioic thioanhydride series was designed, synthesized, evaluated for trichomonacidal and fungicidal activities, and was found to be more active than the standard drug Metronidazole (MTZ). Compounds were trichomonicidal in the MIC ranges of 4.77-294...
November 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29216470/occurrence-and-risk-assessment-of-antibiotics-in-water-and-lettuce-in-ghana
#13
David Azanu, Bjarne Styrishave, Godfred Darko, Johan Juhl Weisser, Robert Clement Abaidoo
Hospital wastewater and effluents from waste stabilization ponds in Kumasi, Ghana, are directly discharged as low quality water into nearby streams which are eventually used to irrigate vegetables. The presence of 12 commonly used antibiotics in Ghana (metronidazole, ciprofloxacin, erythromycin, trimethoprim, ampicillin, cefuroxime, sulfamethoxazole, amoxicillin, tetracycline, oxytetracycline, chlortetracycline and doxycycline) were investigated in water and lettuce samples collected in three different areas in Kumasi, Ghana...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216246/draft-genome-sequence-of-actinotignum-schaalii-dsm-15541t-genetic-insights-into-the-lifestyle-cell-fitness-and-virulence
#14
Atteyet F Yassin, Stefan Langenberg, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Supratim Mukherjee, T B K Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Tanja Woyke, Nikos C Kyrpides
The permanent draft genome sequence of Actinotignum schaalii DSM 15541T is presented. The annotated genome includes 2,130,987 bp, with 1777 protein-coding and 58 rRNA-coding genes. Genome sequence analysis revealed absence of genes encoding for: components of the PTS systems, enzymes of the TCA cycle, glyoxylate shunt and gluconeogensis. Genomic data revealed that A. schaalii is able to oxidize carbohydrates via glycolysis, the nonoxidative pentose phosphate and the Entner-Doudoroff pathways. Besides, the genome harbors genes encoding for enzymes involved in the conversion of pyruvate to lactate, acetate and ethanol, which are found to be the end products of carbohydrate fermentation...
2017: PloS One
https://www.readbyqxmd.com/read/29214879/inappropriate-treatment-in-helicobacter-pylori-eradication-failure-a-retrospective-study
#15
Huiyi Li, Xiao Liang, Qi Chen, Wei Zhang, Hong Lu
BACKGROUND: In recent years, success rates of empirical H. pylori therapies have fallen in many countries. Although antibiotic resistance and poor adherence are described as the main factors for treatment failure, in China, iatrogenic factors also play an important role. OBJECTIVE: To investigate why patients experienced multiple failures, we performed a retrospective, single center study using questionnaires to identify causes of treatment failure other than antibiotic resistance...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29213261/antibiotic-induced-alterations-in-gut-microbiota-are-associated-with-changes-in-glucose-metabolism-in-healthy-mice
#16
Richard R Rodrigues, Renee L Greer, Xiaoxi Dong, Karen N DSouza, Manoj Gurung, Jia Y Wu, Andrey Morgun, Natalia Shulzhenko
The gut microbiome plays an important role in health and disease. Antibiotics are known to alter gut microbiota, yet their effects on glucose tolerance in lean, normoglycemic mice have not been widely investigated. In this study, we aimed to explore mechanisms by which treatment of lean mice with antibiotics (ampicillin, metronidazole, neomycin, vancomycin, or their cocktail) influences the microbiome and glucose metabolism. Specifically, we sought to: (i) study the effects on body weight, fasting glucose, glucose tolerance, and fasting insulin, (ii) examine the changes in expression of key genes of the bile acid and glucose metabolic pathways in the liver and ileum, (iii) identify the shifts in the cecal microbiota, and (iv) infer interactions between gene expression, microbiome, and the metabolic parameters...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29212313/clinical-outcomes-of-standard-triple-therapy-plus-probiotics-or-concomitant-therapy-for-helicobacter-pylori-infection
#17
Jae Hyun Jung, In Kuk Cho, Chang Hee Lee, Gwan Gyu Song, Ji Hyun Lim
Background/Aims: The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection. Methods: We reviewed the medical records of 361 patients who received either STP (n=286) or CT (n=75). The STP group received STT combined with a probiotic preparation for 1 week...
December 8, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29204849/human-intestinal-spirochetosis-mimicking-ulcerative-colitis
#18
Shin Nishii, Masaaki Higashiyama, Sho Ogata, Shunsuke Komoto, Suguru Ito, Akinori Mizoguchi, Hisato Terada, Hirotaka Furuhashi, Takeshi Takajo, Kazuhiko Shirakabe, Chikako Watanabe, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
Human intestinal spirochetosis (HIS) is a colorectal infection caused by the Brachyspira species of intestinal spirochetes, whose pathogenicity in humans remains unclear owing to the lack of or mild symptoms. We monitored the 5-year clinical course of a woman diagnosed with HIS in whom ulcerative colitis (UC) had been suspected. Following a positive fecal occult blood test, she underwent a colonoscopic examination at a local clinic where she was diagnosed with "right-sided" UC concomitant with incidentally detected HIS, and was referred to our hospital...
December 4, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29203432/propionibacterium-acnes-prosthetic-joint-infection-diagnosis-and-treatment
#19
REVIEW
P Boisrenoult
Propionibacterium acnes is a commensal skin bacterium, regularly implicated in prosthetic joint infection, particularly of the shoulder. Diagnosis has been improved by progress in bacteriological techniques: longer culture time, liquid medium culture, MALDI-TOF mass spectrography, and universal 16S rRNA PCR, associated by some authors to sonication of ablated implants. P. acnes pathogenicity involves many virulence factors, notably including biofilm formation. P. acnes may lead to infection that is clinically evident or, frequently, relatively asymptomatic...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29197284/detection-of-ppcps-in-marine-organisms-from-contaminated-coastal-waters-of-the-saudi-red-sea
#20
Aasim M Ali, Helene Thorsen Rønning, Leiv K Sydnes, Walied M Alarif, Roland Kallenborn, Sultan S Al-Lihaibi
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase extraction was applied to isolate the compounds, and their quantification was carried out by high performance liquid chromatography-tandem mass spectrometry. Atenolol, ranitidine, chlorpheniramine, DEET, and atrazine were detected in one or more macroalgae at <LOQ concentration, whereas caffeine, methylparaben, and carbamazepine were present atmaximum concentrations of 41...
November 29, 2017: Science of the Total Environment
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