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https://www.readbyqxmd.com/read/29933220/development-of-a-uplc-ms-ms-method-for-quantitation-of-metronidazole-and-2-hydroxy-metronidazole-in-human-plasma-and-its-application-to-a-pharmacokinetic-study
#1
Stephani L Stancil, Leon van Haandel, Susan Abdel-Rahman, Robin E Pearce
An ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS/MS) method for simultaneous quantitation of metronidazole and 2-hydroxymetronidazole in human plasma was developed and validated. Metronidazole and 2-hydroxymetronidazole were extracted from a small volume of human plasma (10 μL) by hydrophilic lipophilic balanced solid phase extraction on 96-well μ-elution plates. Chromatographic separation of analytes was achieved on an Acquity UPLC BEH C18 column (1.7 μm, 2.1 × 100 mm) using gradient elution with a blend of 0...
June 14, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29932082/bismuth-based-quadruple-helicobacter-pylori-eradication-regimen-alters-the-composition-of-gut-microbiota
#2
Serap Süzük Yildiz, Meltem Yalinay, Tarkan Karakan
Microbiota is a dynamic system showing individual differences in both the number and species of microorganisms. Dietary habits, lifestyle, age, genetic predisposition of the host and use of antibiotics are effective on microbiota. The aim of our research was to carry out a quantitative comparison of Bifidobacterium spp, Bacteroides fragilis, Lactobacillus spp, Akkermansia mucinophilia and Faecalibacterium prausnitzii, important bacterial microbiota species, before and after antibiotic therapy treated with tetracycline and metronidazole in patients who are diagnosed as positive for Helicobacter pylori (HP), and to determine the effects of antibiotic use on the microbiota...
June 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#3
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29925321/prevalence-of-clarithromycin-resistance-in-helicobacter-pylori-in-santiago-chile-estimated-by-real-time-pcr-directly-from-gastric-mucosa
#4
Patricio Gonzalez-Hormazabal, Maher Musleh, Susana Escandar, Hector Valladares, Enrique Lanzarini, V Gonzalo Castro, Lilian Jara, Zoltan Berger
BACKGROUND: Current available treatments for Helicobacter pylori eradication are chosen according to local clarithromycin and metronidazole resistance prevalence. The aim of this study was to estimate, by means of molecular methods, both clarithromycin and metronidazole resistance in gastric mucosa from patients infected with H.pylori. METHODS: A total of 191 DNA samples were analyzed. DNA was purified from gastric mucosa obtained from patients who underwent an upper gastrointestinal endoscopy at an university hospital from Santiago, Chile, between 2011 and 2014...
June 20, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29924770/potential-drug-drug-interactions-with-antimicrobials-in-hospitalized-patients-a-multicenter-point-prevalence-study
#5
Ferit Kuscu, Aslihan Ulu, Ayse S Inal, Bedia M Suntur, Hande Aydemir, Serdar Gul, Kenan Ecemis, Suheyla Komur, Behice Kurtaran, Ozlem Ozkan Kuscu, Yesim Tasova
BACKGROUND Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. MATERIAL AND METHODS This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged ³18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex® online drug reference system was used to control and describe the interactions...
June 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29924052/molecular-epidemiology-and-antimicrobial-susceptibility-of-human-clostridium-difficile-isolates-from-a-single-institution-in-northern-china
#6
Baoya Wang, Zhi Lv, Pingping Zhang, Jianrong Su
Because the epidemiology of Clostridium difficile infection (CDI) is region-specific, the present study was undertaken to examine the epidemiology of C difficile outbreaks in Beijing, China.Eighty nonduplicate isolates were collected from March, 2016 to December, 2016. The molecular type and phylogenetic analysis were evaluated by multilocus sequence typing (MLST). The minimum inhibitory concentrations (MICs) for 11 antibiotics and the resistance mechanisms were investigated.Sixty-five toxigenic strains (81...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29920312/entangled-and-colloidally-stable-microcrystalline-cellulose-matrices-in-controlled-drug-release
#7
Yujiao Dong, Heli Paukkonen, Wenwen Fang, Eero Kontturi, Timo Laaksonen, Päivi Laaksonen
Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices...
June 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29916971/cervicofacial-necrotizing-fasciitis-and-drugs
#8
Laís Sara Egas, Erik Neiva Ribeiro de Carvalho Reis, Leonardo Freitas da Silva, João Paulo Bonardi, Valthierre Nunes de Lima, Pedro Henrique Silva Gomes Ferreira, Ciro Borges Duailibe de Deus, Idelmo Rangel Garcia Júnior
Necrotizing fasciitis (NF) is a devastating disease that typically affects immunocompromised patients, chronically debilitated patients or drug users, but can also affect healthy patients. Necrotizing fasciitis can rapidly produce septic shock and requires immediate surgical management of the necrotic tissue. It is a bacterial infection that progresses rapidly and has a high mortality generally caused by aerobic and anaerobic bacteria. The patient was immunocompromised and drug user. During treatment, a combination of broad-spectrum antibiotic therapy with Ciprofloxacin and Metronidazole, besides the use of activated charcoal dressing composed of carbonized fabric and impregnated with 0...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916184/antibiotics-protect-against-eae-by-increasing-regulatory-and-anti-inflammatory-cells
#9
Hilary A Seifert, Gil Benedek, Ha Nguyen, Grant Gerstner, Ying Zhang, Gail Kent, Arthur A Vandenbark, Jürgen Bernhagen, Halina Offner
A seven day pretreatment course of an oral antibiotic cocktail (Ampicillin, Metronidazole, Neomycin Sulfate, and Vancomycin) was shown to induce changes in peripheral immune regulation and protect mice from signs of experimental autoimmune encephalomyelitis (EAE). To determine if a shorter course of antibiotic pretreatment could also protect the mice from EAE and induce regulatory immune cells, studies were conducted using the same oral antibiotic cocktail for three days. In addition, the CNS was examined to determine the effects of antibiotic pretreatment on EAE disease course and immune modulation within the affected tissue...
June 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29915642/patient-preferences-and-therapeutic-satisfaction-with-topical-agents-for-rosacea-a-survey-based-study
#10
Todd Williamson, Wendy Y Cheng, Nora McCormick, Francis Vekeman
Background: Rosacea is a chronic inflammatory skin disorder that primarily affects the convexities of the central face. Depending on the severity and type of rosacea, physicians may prescribe interventions such as behavioral changes, laser and intense pulsed light, as well as various pharmacologic therapies, including topical agents. The impact of side effects associated with topical treatments for rosacea on patient preferences and treatment satisfaction is not well-documented. Objective: To assess patients' concerns, treatment satisfaction, and quality of life (QOL) associated with topical treatments for rosacea...
April 2018: American Health & Drug Benefits
https://www.readbyqxmd.com/read/29911329/helicobacter-pylori-antibiotic-resistance-in-portugal-systematic-review-and-meta-analysis
#11
REVIEW
Inês Lopo, Diogo Libânio, Inês Pita, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
BACKGROUND: Portugal presents both a high prevalence of Helicobacter pylori (Hp) infection and a high prevalence of antibiotic resistance. However, conclusive data on its magnitude are lacking. We aimed at summarizing the existing data. MATERIALS AND METHODS: A systematic review was conducted after searching in two databases (PubMed and SciELO). Meta-analysis was performed, and comparison of resistance rates between children and adults and by type of resistance (primary and secondary) was made...
June 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29910467/gut-microbiota-modulate-neurobehavior-through-changes-in-brain-insulin-sensitivity-and-metabolism
#12
Marion Soto, Clémence Herzog, Julian A Pacheco, Shiho Fujisaka, Kevin Bullock, Clary B Clish, C Ronald Kahn
Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have behaviors reflective of increased anxiety and depression. This is associated with decreased insulin signaling and increased inflammation in in the nucleus accumbens and amygdala...
June 18, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29909695/anti-infective-treatment-of-brain-abscess
#13
Jacob Bodilsen, Matthijs C Brouwer, Henrik Nielsen, Diederik van de Beek
INTRODUCTION: Brain abscess is an uncommon and potentially life-threatening infection of the CNS that can be caused by a range of different pathogens including bacteria, fungi and parasites. A multidisciplinary approach is important and anti-infective treatment remains crucial. Here, we review anti-infective treatment of brain abscess. Areas covered: We used the terms '(Brain abscess[ti] AND (antibiotic* OR treatment)) NOT case report'), to conduct a search in the PubMed. Additional papers were identified by cross-reference checking and by browsing textbooks of infectious diseases and neurology...
June 18, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29903711/cost-effectiveness-analysis-of-initial-treatment-strategies-for-mild-to-moderate-clostridium-difficile-infection-in-hospitalized-patients
#14
Diana C Ford, Mary C Schroeder, Dilek Ince, Erika J Ernst
PURPOSE: The cost-effectiveness of initial treatment strategies for mild-to-moderate Clostridium difficile infection (CDI) in hospitalized patients was evaluated. METHODS: Decision-analytic models were constructed to compare initial treatment with metronidazole, vancomycin, and fidaxomicin. The primary model included 1 recurrence, and the secondary model included up to 3 recurrences. Model variables were extracted from published literature with costs based on a healthcare system perspective...
June 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29896736/-phylogenetic-study-of-drug-resistance-genes-from-clinical-isolates-of-helicobacter-pylori
#15
Baoning Wang, Li Wan, Yongjun Zhou, Mingjiang Bie, Zhenmei An, Hengjian Huang, Chengzhi Tang
To carry out phylogenetic analysis for drug-resistance genes from clinical isolates of Helicobacter pylori (Hp) among patients with gastric diseases from Tibet, China. METHODS: Hp strains were isolated and cultured from saliva and gastric mucosal tissues derived from patients with gastric diseases. Nine strains (including 5 isolated from oral tissues, 1 isolated from gastric tissues, and 3 representative strains of SS international standard strains used for animal models) were tested for common antibiotic resistance...
June 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29896497/experimental-data-of-electric-coagulation-and-photo-electro-phenton-process-efficiency-in-the-removal-of-metronidazole-antibiotic-from-aqueous-solution
#16
Bahram Kamarehie, Fatemeh Ahmadi, Faria Hafezi, Ali Abbariki, Rouhollah Heydari, Mohammad Amin Karami
Pharmaceutical products, particularly antibiotics, due to their cumulative characteristics, undesirable effects and creating drug resistances, as inevitably pollutants, poses a major concern in environmental issues. In recent years, advanced oxidation processes (AOP) have been considerably used for degradation of new and emerging pollutants such as residual medications and resistant compounds in water and wastewater. Present investigation evaluates the removal of metronidazole from aqueous solution by electro coagulation and photoelectrophenton processes...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29893585/false-positive-phencyclidine-immunoassay-results-caused-by-metronidazole
#17
Nicolás Fernández, Florencia Falguera, Laura M Cabanillas, Patricia N Quiroga
No abstract text is available yet for this article.
June 12, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29892535/periodontal-thermoresponsive-mucoadhesive-dual-antimicrobial-loaded-in-situ-gel-for-the-treatment-of-periodontal-disease-preparation-in-vitro-characterization-and-antimicrobial-study
#18
Monika Bansal, Neelam Mittal, Sarita Kumari Yadav, Gayasuddin Khan, Pooja Gupta, Brahmeshwar Mishra, Gopal Nath
Background: This study aimed to formulate and characterize in-situ gel containing levofloxacin and metronidazole to release drugs in controlled manner for treatment of periodontitis. Material and Methods: Medicated in-situ gel with levofloxacin (10% w/v), metronidazole (25% w/v) and vehicle in-situ gel without drugs having poloxamer 407 (20% w/v) and chitosan (0.5%, 1%, 1.5%, 2.0% 2.5% w/v) were prepared and characterized for physicochemical, mechanical properties, stability and in-vitro drug release...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29892525/treatment-of-odontogenic-infections-an-analysis-of-two-antibiotic-regimens
#19
Manish Bhagania, Wael Youseff, Pushkar Mehra, Ruben Figueroa
Purpose: Retrospective analysis of the efficacy for two commonly used antibiotic regimens in the management of severe odontogenic infections. Patients and Methods: Evaluation of records of patients admitted to the Oral and Maxillofacial Surgery service at Boston University Medical Center from 2009 to 2014 with severe infections of odontogenic origin (SOI). Patients were divided into two groups based on the administered intravenous antibiotic: 1) Group I: Clindamycin only and 2) Group II: Penicillin and Metronidazole...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29890556/-management-of-clostridium-difficile-infections-at-german-intensive-care-units-results-from-a-survey-among-intensivists
#20
Jan Bruensing, Lukas Buendgens, Christoph Jochum, Ulf Herbers, Ali Canbay, Georg Braun, Christian Trautwein, Wolfgang Huber, Alexander Koch, Frank Tacke
BACKGROUND: Clostridium difficile associated colitis is a frequent cause of nosocomial diarrhea at the intensive care unit (ICU) and is associated with poor prognosis in critically ill patients. Few studies have evaluated the efficacy of treatment options or adherence to guideline recommendations of Clostridium difficile infections at the ICU. METHODS: Therefore, on behalf of the Gastroenterology Intensive Care Medicine working group of the DGVS, we have conducted an online-based survey among leading intensivists in Germany...
June 2018: Zeitschrift Für Gastroenterologie
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