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https://www.readbyqxmd.com/read/28625320/expression-of-jagged1-notch3-signaling-pathway-and-their-relationship-with-the-tumor-angiogenesis-in-tnbc
#1
Siliang Xue, Lang He, Xiao Zhang, Jin Zhou, Fanghua Li, Xiaoshan Wang
BACKGROUND AND AIMS: Jagged1/Notch3 signaling pathway plays a key role in angiogenesis of breast cancer, but little is known in TNBC. This study was designed to investigate the expression of Jagged1/Notch3 mRNA and protein in TNBC, analyze their correlations with clinicopathological characteristics and prognosis. Moreover, the interrelationship among Jagged1/Notch3 and VEGF was initially evaluated. METHODS: Jagged1/Notch3 mRNA and protein expression levels were determined by Q-RT-PCR and Western blotting...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28621261/ag488-as-a-therapy-against-gliomas
#2
Jadith Ziegler, Anja Bastian, Megan Lerner, Lora Bailey-Downs, Debra Saunders, Nataliya Smith, Jake Sutton, James D Battiste, Michael A Ihnat, Aleem Gangjee, Rheal A Towner
High-grade gliomas such as glioblastomas (GBM) present a deadly prognosis following diagnosis and very few effective treatment options. Here, we investigate if the small molecule AG488 can be an effective therapy against GBM with both anti-angiogenic as well as an anti-microtubule inhibiting modalities, using a human G55 glioma xenograft model in nude mice. From in vitro studies, we report that AG488 incubation reduced cell viability in G55 and HMEC-1 cells more so than TMZ treatment, and AG488 treatment also decreased cell viability in normal astrocytes, but not as much as for G55 cells (p<0...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28616914/-expressions-and-significance-of-aldh1-hif-1%C3%AE-and-vegf-in-laryngeal-squamous-cell-carcinoma
#3
Yan Zhao, Xin Jin, Nan Li, Yan-Zi Qin, Jun Qian
OBJECTIVES: To investigate the expressions of aldehyde dehydrogenase 1(ALDH1), hypoxia-inducible factor 1α(HIF-1α), vascular endothelial growth factor (VEGF) in laryngeal squamous cell carcinoma(LSCC) and their relationships with clinical significance. METHODS: In situ hybridization (ISH) method and immuohistochemical staining were used to detect the mRNA and protein expressions of ALDH1, HIF-1α and VEGF in 120 LSCC specimens and 60 cases of normal laryngeal tissue...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28612593/2-methoxyestradiol-promotes-radiosensitivity-of-esophageal-squamous-cell-carcinoma-by-suppressing-hypoxia-inducible-factor-1%C3%AE-expression
#4
Yanrong Lu, Jia Song, Zhabihula Baerxiaguli, Zengyan Li, Min Wu, Jinrong Zhang
Background: Acquired radioresistance remains a primary obstacle to improving survival of patients with esophageal cancer(EC). Factors related to hypoxia play crucial roles in such radioresistance, such as hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenic factor with G-patch and FHA domains 1 (AGGF1). However, evidence clarifying the role of AGGF1 in EC is limited. We here aimed to investigate the effects of 2-methoxyestradiol(2ME2) on the radiosensitivity of EC...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28609484/the-clinical-and-prognostic-correlation-of-hrnpm-and-slc1a5-in-pathogenesis-and-prognosis-in-epithelial-ovarian-cancer
#5
Kathrine Bjersand, Tomas Seidal, Inger Sundström-Poromaa, Helena Åkerud, Ingiridur Skirnisdottir
OBJECTIVES: To evaluate the prognostic effect of the Heterogeneous nuclear ribonucleoprotein type M (HNRPM) and Solute carrier 1A5 (SLC1A5) in FIGO-stages I-II epithelial ovarian cancer. METHODS: A retrospective cohort study was designed to investigate the prognostic effect of HNRPM and SLC1A5, and the association with clinical-pathologic characteristics in 131 patients with FIGO-stages I-II epithelial ovarian cancer. Tissue microarrays were constructed and protein levels were assessed by immunohistochemistry (IHC)...
2017: PloS One
https://www.readbyqxmd.com/read/28607581/pembrolizumab-in-cervical-cancer-latest-evidence-and-clinical-usefulness
#6
REVIEW
Edith Borcoman, Christophe Le Tourneau
Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. With the development of detection of precancerous lesions and preventive human papillomavirus (HPV) vaccination program, a survival improvement has been observed in these patients in developed countries, although disparities in accessibility to treatments exist across countries. While early-stage cervical cancer can be curable with surgery, prognosis of patients who recur remains poor, with limited treatment options...
June 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28597184/epithelial-membrane-protein-2-emp2-promotes-angiogenesis-in-glioblastoma-multiforme
#7
Yu Qin, Masamichi Takahashi, Kristopher Sheets, Horacio Soto, Jessica Tsui, Panayiotis Pelargos, Joseph P Antonios, Noriyuki Kasahara, Isaac Yang, Robert M Prins, Jonathan Braun, Lynn K Gordon, Madhuri Wadehra
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and is associated with an extremely poor clinical prognosis. One pathologic hallmark of GBM is excessive vascularization with abnormal blood vessels. Extensive investigation of anti-angiogenic therapy as a treatment for recurrent GBM has been performed. Bevacizumab, a monoclonal anti-vascular endothelial growth factor A (VEGF-A), suggests a progression-free survival benefit but no overall survival benefit. Developing novel anti-angiogenic therapies are urgently needed in controlling GBM growth...
June 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28594322/caspase-8-contributes-to-angiogenesis-and-chemotherapy-resistance-in-glioblastoma
#8
Giulia Fianco, Maria Patrizia Mongiardi, Andrea Levi, Teresa De Luca, Marianna Desideri, Daniela Trisciuoglio, Donatella Del Bufalo, Irene Cinà, Anna Di Benedetto, Marcella Mottolese, Antonietta Gentile, Diego Centonze, Fabrizio Ferrè, Daniela Barilà
Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these contexts. GBM, the most aggressive of the gliomas, is characterized by extensive angiogenesis and by an inflammatory microenvironment that support its development and resistance to therapies. We have recently shown that Caspase-8 sustains neoplastic transformation in vitro in human GBM cell lines...
June 8, 2017: ELife
https://www.readbyqxmd.com/read/28592625/current-clinical-practice-guidelines-for-the-treatment-of-renal-cell-carcinoma-a-systematic-review-and-critical-evaluation
#9
Aristotle Bamias, Bernard Escudier, Cora N Sternberg, Flora Zagouri, Athanasios Dellis, Bob Djavan, Kimon Tzannis, Loukas Kontovinis, Konstantinos Stravodimos, Athanasios Papatsoris, Dionysios Mitropoulos, Charalampos Deliveliotis, Meletios-Athanasios Dimopoulos, Constantine A Constantinides
The landscape of local and systemic therapy of renal cell carcinoma (RCC) is rapidly changing. The increase in the incidental finding of small renal tumors has increased the application of nephron-sparing procedures, while ten novel agents targeting the vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin pathways, or inhibiting the interaction of the programmed death 1 receptor with its ligand, have been approved since 2006 and have dramatically improved the prognosis of metastatic RCC (mRCC)...
June 2017: Oncologist
https://www.readbyqxmd.com/read/28590926/transcriptional-factor-oct4-promotes-esophageal-cancer-metastasis-by-inducing-epithelial-mesenchymal-transition-through-vegf-c-vegfr-3-signaling-pathway
#10
Chunguang Li, Maoling Zhu, Xiaoli Lou, Chunying Liu, Hezhong Chen, Xuejing Lin, Weidan Ji, Zhigang Li, Changqing Su
The octamer-binding transcription factor 4 (OCT4) can promote cancer proliferation and metastasis. Esophageal carcinoma (ECC) harbors different quantities of OCT4-positive cancer cells. These cells are highly malignant and prone to metastasis; however, the mechanism remains unknown. In this study, we found that OCT4 enhances vascular endothelial growth factor C (VEGF-C) promoter activity to promote VEGF-C expression and activates VEGF receptor 3 (VEGFR-3) in ECC cells, thereby inducing cancer cell epithelial-mesenchymal transition (EMT)...
May 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28582381/high-expression-of-retinoblastoma-binding-protein-2-rbp2-in-patients-with-hepatocellular-carcinoma-and-its-prognostic-significance
#11
Zhen-Yu Wang, Jie Yang, Chang-Kuo Liu, Shi-Qiang Shen
BACKGROUND Recently, some studies have found that retinoblastoma-binding protein 2 (RBP2) is involved in the development and progression of many kinds of malignant tumors. This study aimed to explore the expression level of RBP2 in hepatocellular carcinoma (HCC) and its prognostic significance. MATERIAL AND METHODS Immunohistochemical analysis was used to evaluate the RBP2 expression level in 130 HCC patients and adjacent normal tissues. Tumor angiogenesis was marked by CD31 and vascular endothelial growth factor (VEGF) staining...
June 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28581513/kif26b-a-novel-oncogene-promotes-proliferation-and-metastasis-by-activating-the-vegf-pathway-in-gastric-cancer
#12
H Zhang, R-R Ma, X-J Wang, Z-X Su, X Chen, D-B Shi, X-Y Guo, H-T Liu, P Gao
Tumor metastasis is the main reason of cancer-related death for gastric cancer (GC) patients and gene expression microarray data indicate that kinesin family member 26B (KIF26B) is one of the most upregulated genes in metastatic GC samples. Specifically, KIF26B expression was upregulated in a stepwise manner from non-tumorous gastric mucosa, primary GC tissues without metastasis, via primary GC tissues with metastasis, to secondary lymph node metastatic (LNM) foci. Increased expression of KIF26B was correlated with tumor size, positive LNM or distant metastases and poor prognosis...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28577731/thrombotic-microangiopathies-and-antineoplastic-agents
#13
Steven Grangé, Paul Coppo
Thrombotic microangiopathy is a well-described complication of cancer treatment. Its incidence has increased these last decades, as a result of a better awareness of this complication in cancer patients in one hand, but also of a larger array of therapeutic compounds including anti-vascular endothelium growth factor (VEGF) drugs. It is therefore mandatory to recognize these conditions since they have a significant impact in thrombotic microangiopathies management and prognosis. Practitioners should be aware of the more classical antineoplastic agents associated with thrombotic microangiopathies, the mechanisms by which they induce them, and the resulting management and prognosis...
April 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28574932/vascular-endothelial-growth-factor-vegf-polymorphisms-and-serum-vegf-levels-in-women-with-epithelial-ovarian-cancer-benign-tumors-and-healthy-ovaries
#14
Blanca González-Palomares, Pluvio J Coronado Martín, María Luisa Maestro de Las Casas, Silvia Veganzones de Castro, Sara Rafael Fernández, Marta Vidaurreta Lázaro, Virginia De la Orden García, Jose Antonio Vidart Aragon
OBJECTIVE: This study analyzed the relation of 5 single-nucleotide polymorphisms (SNPs) in the VEGF (vascular endothelial growth factor) gene in patients with epithelial ovarian cancer (EOC), compared with patients carrying benign tumors or healthy ovaries. We studied serum VEGF levels and the relation with SNPs and association between VEGF SNPs and haplotypes with progression-free survival (PFS) in patients with cancer. METHODS: The genotyping of VEGF gene polymorphisms (-2578 C/A, -1154 G/A, -460 T/C, +405 G/C, +936 C/T) was performed in DNA isolated from blood samples of 100 women...
June 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28574600/diallyl-trisulfides-a-natural-histone-deacetylase-inhibitor-attenuate-hif-1%C3%AE-synthesis-and-decreases-breast-cancer-metastasis
#15
Zhonghong Wei, Yunlong Shan, Li Tao, Yuping Liu, Zhijie Zhu, Zhaoguo Liu, Yuanyuan Wu, Wenxing Chen, Aiyun Wang, Yin Lu
Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level of hypoxia-inducible factor-1α (HIF-1α) reflects the prognosis of a variety of cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF-1α protein due to von Hippel-Lindau protein-dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported as HDAC inhibitors. The effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) on the ratio of firefly/Renilla luciferase activity in hypoxic MDA-MB-231 cells were determined...
June 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28562696/pth-1-34-improves-the-effects-of-core-decompression-in-early-stage-steroid-associated-osteonecrosis-model-by-enhancing-bone-repair-and-revascularization
#16
Chen-He Zhou, Jia-Hong Meng, Chen-Chen Zhao, Chen-Yi Ye, Han-Xiao Zhu, Bin Hu, Boon Chin Heng, Yue Shen, Tiao Lin, Xiao-Bo Yang, Zhong-Li Shi, Wei-Liang Shen, Shi-Gui Yan
Steroid-associated osteonecrosis (SAON) might induce bone collapse and subsequently lead to joint arthroplasty. Core decompression (CD) is regarded as an effective therapy for early-stage SAON, but the prognosis is unsatisfactory due to incomplete bone repair. Parathyroid hormone[1-34] (PTH[1-34]) has demonstrated positive efficacy in promoting bone formation. We therefore evaluated the effects of PTH on improving the effects of CD in Early-Stage SAON. Distal femoral CD was performed two weeks after osteonecrosis induction or vehicle injection, with ten of the ON-induced rabbits being subjected to six-week PTH[1-34] treatment and the others, including ON-induced and non-induced rabbits, being treated with vehicle...
2017: PloS One
https://www.readbyqxmd.com/read/28557832/serum-vascular-endothelial-growth-factor-a-as-a-prognostic-biomarker-for-epithelial-ovarian-cancer
#17
Hiroaki Komatsu, Tetsuro Oishi, Hiroaki Itamochi, Muneaki Shimada, Shinya Sato, Jun Chikumi, Seiya Sato, Michiko Nonaka, Mayumi Sawada, Makoto Wakahara, Yoshihisa Umekita, Tasuku Harada
BACKGROUND: Bevacizumab, which targets vascular endothelial growth factor (VEGF)-A, has recently been proven to be effective for the treatment of epithelial ovarian cancer (EOC). Thus, interest in VEGF-A has increased. There are few reports on concomitant detection of both ligands and its soluble receptors in serum samples, and the significance of serum VEGF-A in EOC is unclear, unlike the situation with tissue samples. We conducted the present study to explore the levels of serum VEGF family and its receptors and to evaluate their utility as prognostic biomarkers...
May 26, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28545581/increased-serum-level-of-soluble-interleukin-2-receptor-is-associated-with-a-worse-response-of-metastatic-clear-cell-renal-cell-carcinoma-to-interferon-alpha-and-sequential-vegf-targeting-therapy
#18
Akinori Nukui, Akinori Masuda, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida, Takao Kamai
BACKGROUND: Renal cell carcinoma (RCC) is a tumor with immunogenic properties. Soluble interleukin-2 receptor (sIL-2R) has a role in T cell activation and may be important for immune regulation in various conditions, including infections, transplantation rejection, autoimmune inflammatory states, and cancer. We investigated the prognostic value of the serum sIL-2R level in patients with metastatic RCC receiving IFN-alpha and vascular endothelial growth factor (VEGF)-targeting therapy...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28523303/prognostic-factors-in-squamous-cell-carcinoma-of-the-lower-lip-an-immunohistochemical-study
#19
Raluca Niculina Ciurea, Virgil Pătraşcu, Cristiana Eugenia Simionescu, Alex Emilian Stepan, Dragoş George Popa, Marius Eugen Ciurea, Andreea Oana Enache, Stelian ŞtefăniŢă Mogoantă, Daniel Pirici
Squamous cell carcinoma (SCC) of the lip represents 15-30% of SCC of cephalic extremity, located on the lower lip in about 90% of cases. The present paper aimed to define the profile of SCC of the lip with major risk factors. The study included 20 selected cases diagnosed with lower lip SCC, using a panel of antibodies which addressed cell proliferation (Ki67), perturbation of the cell cycle (p53), angiogenesis (VEGF - vascular endothelial growth factor), factors related to tumor cell interaction with the extracellular matrix (CD44)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521969/natriuretic-peptide-receptor-a-is-related-to-the-expression-of-vascular-endothelial-growth-factors-a-and-c-and-is-associated-with-the-invasion-potential-of-tongue-squamous-cell-carcinoma
#20
Y Nakao, S Yamada, S Yanamoto, T Tomioka, T Naruse, T Ikeda, H Kurita, M Umeda
Natriuretic peptide receptor A (NPRA) is one of the natriuretic peptide receptors. NPRA has been reported to play a role in the carcinogenesis of various tumours, as well as functional roles in renal, cardiovascular, endocrine, and skeletal homeostasis. The clinicopathological significance of NPRA in tongue squamous cell carcinoma (TSCC) was examined in this study. The overexpression of NPRA was more frequent in TSCC (21/58, 36.2%) than in the normal oral epithelium (0/10, 0%) (P<0.05). It was also more frequently observed in cancers with higher grades according to the pattern of invasion (grades 1-2 vs...
May 15, 2017: International Journal of Oral and Maxillofacial Surgery
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