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https://www.readbyqxmd.com/read/29048943/prognostic-value-of-the-combination-of-serum-levels-of-vascular-endothelial-growth-factor-c-reactive-protein-and-contrast-enhanced-ultrasound-in-patients-with-primary-liver-cancer-who-underwent-transcatheter-arterial-chemoembolization
#1
Zhi-Dong Xuan, Li Zhou, Yu Wang, Xue Zheng
BACKGROUND: This study aimed to evaluate the prognostic value of the combination of serum levels of vascular endothelial growth factor (VEGF), C-reactive protein (CRP), and contrast-enhanced ultrasound (CEUS) in patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE). RESEARCH DESIGN AND METHODS: Overall, 287 PLC patients who had undergone TACE were allocated into recurrence and non-recurrence groups. One day before and seven days after TACE, CEUS was performed, and serum VEGF and CRP levels were determined...
October 19, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29048623/vegfr3-inhibition-chemosensitizes-lung-adenocarcinoma-a549-cells-in-the-tumor-associated-macrophage-microenvironment-through-upregulation-of-p53-and-pten
#2
Ya Li, Yaguang Weng, Liang Zhong, Huimin Chong, Sicheng Chen, Yanting Sun, Wang Li, Qiong Shi
In lung adenocarcinoma, loss of p53 and PTEN in tumors are associated with decreased response to chemotherapy and decreased survival. A means to pharmacologically upregulate p53 and PTEN protein expression could improve the prognosis of patients with p53- and PTEN-deficient tumors. In the present study we revealed that vascular endothelial growth factor receptor 3 (VEGFR3) inhibition in lung adenocarcinoma cells was associated with improved expression levels of both p53 and PTEN in the tumor-associated macrophage (TAM) microenvironment...
September 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039593/hyperthermia-with-different-temperatures-inhibits-proliferation-and-promotes-apoptosis-through-the-egfr-stat3-pathway-in-c6-rat-glioma-cells
#3
Yao-Dong Chen, Yu Zhang, Tian-Xiu Dong, Yu-Tong Xu, Wei Zhang, Ting-Ting An, Peng-Fei Liu, Xiu-Hua Yang
Malignant gliomas are a group of aggressive neoplasms among human cancers. The curative effects of current treatments are finite for improving the prognosis of patients. Hyperthermia (HT) is an effective treatment for cancers; however, the effects of HT with different temperatures in treatment of MG and relevant mechanisms remain unclear. MTT assay and Annexin V‑fluorescein isothiocyanate/propidium iodide staining were used for investigating the proliferation and apoptosis of C6 cells, respectively. Western blotting was applied to detect the expression of proteins...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29033580/the-influence-of-vascular-endothelial-growth-factor-a-and-matrix-metalloproteinase-2-and-9-in-angiogenesis-metastasis-and-prognosis-of-endometrial-cancer
#4
REVIEW
Anna M Mahecha, Hongbo Wang
Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors, especially, during the process of endometrial degeneration and remodeling. In carcinogenesis, tumor hypoxia-induced factors, through the process of "angiogenic switch", stimulate the production of angiogenic factors, particularly VEGF and MMP...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#5
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025597/upregulation-of-vascular-endothelial-growth-factor-vegf-its-role-in-progression-and-prognosis-of-non-small-cell-lung-carcinoma
#6
Niyaz A Naikoo, Roohi Rasool, Sonaullah Shah, A G Ahangar, Mushtaq A Siddiqi, Zafar A Shah
Elevated VEGF mRNA (-ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan-Meier analysis showed that NSCLC patients with higher VEGF mRNA (-ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of -ΔCT <10 (P < 0...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28986088/expression-of-tyrosine-kinase-receptor-axl-is-associated-with-worse-outcome-of-metastatic-renal-cell-carcinomas-treated-with-sunitinib
#7
Luís Eduardo Zucca, Mariana Andozia Morini Matushita, Renato José da Silva Oliveira, Cristovam Scapulatempo-Neto, Marcos Alves de Lima, Guilherme Gomes Ribeiro, Cristiano Ribeiro Viana, Flavio Mavignier Cárcano, Rui Manuel Reis
BACKGROUND: Renal cell carcinoma (RCC) represents 2%-3% of all cancers of the Western countries. Currently, sunitinib, a receptor tyrosine kinase inhibitor, particularly of PDGF and VEGF receptors, is the first-line therapy for metastatic RCC (mRCC), with significant improvement in clinical outcome. However, there is a lack of predictive biomarkers of sunitinib response. Recently, others and our group suggested that the receptor tyrosine kinase AXL may modify the response to sunitinib...
October 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28984690/pd-1-pd-l1-and-vegf-a-vegf-c-expression-in-lymph-node-microenvironment-and-association-with-melanoma-metastasis-and-survival
#8
Cristina Alessi, Cristovam Scapulatempo Neto, Cristiano R Viana, Vinicius de Lima Vazquez
Regional lymph nodes are affected frequently by melanoma metastasis. Its microenvironment may be associated with tumor progression. We investigated sentinel nodes with and without tumor and negative nodes surrounding positive nodes, looking for patterns related to tumor immune interaction and lymphovascular progression. We quantified programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1, vascular endothelial growth factor (VEGF)-A/VEGF-C expressions in lymph nodes of 103 patients who underwent sentinel lymph node biopsy...
October 3, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28981479/ubiquitin-associated-protein-2-like-ubap2l-overexpression-in-patients-with-hepatocellular-carcinoma-and-its-clinical-significance
#9
Wei Wang, Min Zhang, Yan Peng, Jie He
BACKGROUND Recently, accumulating studies have shown that ubiquitin associated protein 2-like (UBAP2L) is overexpressed in many kinds of malignant tumors, which is closely associated to tumor growth and metastasis. However, the correlations of UBAP2L expression with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC) patients still remain unclear. MATERIAL AND METHODS Bioinformatics database (GEO and TCGA) and our own experimental results (including immunohistochemical staining, western blotting and real-time PCR) were analyzed to validate the expression levels of UBAP2L in HCC...
October 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28975984/levels-of-hbx-vegf-and-ceacam1-in-hbv-related-hepatocellular-carcinoma-and-their-correlation-with-cancer-prognosis
#10
C-S Mao, H Yin, H-B Ning, Z Peng, K Li, G-Q Ding
OBJECTIVE: Hepatitis B virus X protein (HBx), vascular endothelial growth factor (VEGF) and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1), are related to HBV associated hepatocellular carcinoma (HCC). This study recruited HCC patients and employed the SMMC-7721 and L02 liver cell lines, to analyze the expression levels of HBx, VEGF and CEACAM1 in liver cancer and their correlation with the cancer prognosis. PATIENTS AND METHODS: HBV-related HCC patients were recruited from our hospital...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975890/identification-and-validation-of-novel-prognostic-markers-in-renal-cell-carcinoma
#11
Maj Rabjerg
Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28963609/overexpression-of-timp-1-and-sensitivity-to-topoisomerase-inhibitors-in-glioblastoma-cell-lines
#12
Charlotte Aaberg-Jessen, Louise Fogh, Mia Dahl Sørensen, Bo Halle, Nils Brünner, Bjarne Winther Kristensen
The multifunctional protein - tissue inhibitor of metalloproteinases-1 (TIMP-1) - has been associated with a poor prognosis in several types of cancers including glioblastomas. In addition, TIMP-1 has been associated with decreased response to chemotherapy, and especially the efficacy of the family of topoisomerase (TOP) inhibitors has been related to TIMP-1. As a second line treatment of glioblastomas, the vascular endothelial growth factor (VEGF) antibody bevacizumab is administered in combination with the TOP1 inhibitor irinotecan and glioblastoma cell levels of TIMP-1 could therefore potentially influence the efficacy of such treatment...
September 30, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28950890/the-value-of-dce-mri-in-assessing-histopathological-and-molecular-biological-features-in-induced-rat-epithelial-ovarian-carcinomas
#13
Su Juan Yuan, Tian Kui Qiao, Jin Wei Qiang, Song Qi Cai, Ruo Kun Li
BACKGROUND: To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs). METHODS: 7,12-dimethylbenz[A]anthracene (DMBA) was applied to induce EOCs in situ in 46 SD rats. Conventional MRI and DCE-MRI were performed to evaluate the morphology and perfusion features of the tumors, including the time-signal intensity curve (TIC), volume transfer constant (K(trans)), rate constant (Kep), extravascular extracellular space volume ratio (Ve) and initial area under the curve (IAUC)...
September 26, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28948065/genetic-alterations-of-idh1-and-vegf-in-brain-tumors
#14
Silvia Veganzones, Virginia de la Orden, Lucía Requejo, Beatriz Mediero, María Luisa González, Náyade Del Prado, Carmen Rodríguez García, Raquel Gutiérrez-González, Alvaro Pérez-Zamarrón, Armando Martínez, Marisa L Maestro, Horacio Mario Zimman, Anna González-Neira, Jesús Vaquero, Gregorio Rodríguez-Boto
BACKGROUND: This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival (OS) and progression free survival (PFS) was evaluated. METHODS: A cohort of 80 patients surgically treated at Hospital Clínico San Carlos, Madrid, between March 2004 and November 2012, was analyzed. Tumors were distributed in 73 primary brain tumors (gliomas, meningiomas, hemangiopericytomas and hemangioblastomas) and seven secondary tumors evolved from a low grade glioma, thus providing a mixed sample...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28947976/identification-of-hub-genes-involved-in-the-development-of-hepatocellular-carcinoma-by-transcriptome-sequencing
#15
Yongchang Zheng, Junyu Long, Liangcai Wu, Haohai Zhang, Lin Li, Ying Zheng, Anqiang Wang, Jianzhen Lin, Xiaobo Yang, Xinting Sang, Ke Hu, Jie Pan, Haitao Zhao
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. The aim of this study was to identify underlying hub genes and dysregulated pathways associated with the development of HCC using bioinformatics analysis. Differentially expressed protein-coding genes were subjected to transcriptome sequencing in 11 pairs of liver cancer tissue and matched adjacent non-cancerous tissue. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, followed by protein-protein interaction (PPI) network construction...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28943915/zoledronic-acid-inhibits-infiltration-of-tumor-associated-macrophages-and-angiogenesis-following-transcatheter-arterial-chemoembolization-in-rat-hepatocellular-carcinoma-models
#16
Da-Yong Zhou, Jie Qin, Jian Huang, Feng Wang, Guo-Peng Xu, Yan-Tian Lv, Ji-Bin Zhang, Li-Ming Shen
Hepatic transcatheter arterial chemoembolization (TACE), a minimally invasive procedure to block the blood supply of tumors and release of cytotoxic agents, is preferentially applied to patients with hepatocellular carcinoma (HCC) who are not able to receive radical treatments. However, the long-term effects of TACE are unsatisfactory, as the microenvironment following procedure stimulates tumor angiogenesis, which promotes recurrence and metastasis of residual tumors. Tumor associated macrophages (TAMs) have been revealed to stimulate tumor growth and angiogenesis associated with poor prognosis in HCC...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928842/significant-response-to-ramucirumab-monotherapy-in-chemotherapy-resistant-recurrent-alpha-fetoprotein-producing-gastric-cancer-a-case-report
#17
Yasuhiro Arakawa, Miho Tamura, Keisuke Aiba, Kazuhiko Morikawa, Daisuke Aizawa, Masahiro Ikegami, Masami Yuda, Katsunori Nishikawa
Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is a relatively rare type of gastric cancer characterized by a high incidence of liver and lymph node metastases, and a poor prognosis. Few advanced AFPGC cases treated successfully with conventional chemotherapy have been reported thus far. Although the development of molecular-targeted therapy has improved the prognosis of various types of cancer, there are currently no tailored therapies for AFPGC. In the present report, the case of a chemotherapy-resistant recurrent AFPGC patient who exhibited a significant response to ramucirumab monotherapy is presented...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927077/associations-between-the-expression-of-mta1-and-vegf-c-in-esophageal-squamous-cell-carcinoma-with-lymph-angiogenesis-and-lymph-node-metastasis
#18
Jianping Liu, Juan Xia, Yongheng Zhang, Maoyong Fu, Sheng Gong, Yulong Guo
The aim of the present study was to investigate the association between the expression levels of metastasis-related gene 1 (MTA1) and vascular endothelial growth factor C (VEGF-C) in esophageal squamous cell carcinoma (ESCC) with lymph angiogenesis and lymph node metastasis. The paraffin-embedded tissue samples of 107 cases of ESCC and 56 cases of normal esophageal tissues were collected from the Department of Cardiothoracic Surgery, Suining Central Hospital from March 2013 to January 2014. Immunohistochemical assays were performed to detect the expression levels of MTA1, VEGF-C and D2-40 in ESCC, and the micro-lymphatic vessel density (LVD) was evaluated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927050/expression-of-tspan-1-gene-in-patients-with-advanced-gastric-cancer
#19
Yaowu Cai, Maosong Zheng, Zhiqiang Zhao, Hanxing Huang, Wenda Fu, Xuefeng Xu
The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III according to the tumor node metastasis (TNM) staging; the immunohistochemical staining method and the semi-quantitative PCR method were used to detect the positive expression rates and mRNA relative expression levels of Tspan-1, vascular endothelial growth factor (VEGF), E-cadherin and N-cadherin...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28917434/quantitative-analysis-of-four-protein-biomarkers-an-automated-microfluidic-cartridge-based-method-and-its-comparison-to-colorimetric-elisa
#20
REVIEW
Mark Dysinger, Greg Marusov, Stephanie Fraser
Biomarker quantitation with ligand binding assays has matured greatly in recent years. This maturation has been partly in response to demands for more data points from fewer samples or less available sample volume. Multiplexing offers opportunities to acquire data for multiple analytes from single sample assay iterations, but has its own unique challenges and limitations. ProteinSimple has developed Simple Plex™, an automated immunoassay platform consisting of microfluidic cartridge-based assays run on the Ella instrument...
September 13, 2017: Journal of Immunological Methods
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