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OLM Interneuron

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https://www.readbyqxmd.com/read/26386153/early-postnatal-nicotine-exposure-disrupts-the-%C3%AE-2-nicotinic-acetylcholine-receptor-mediated-control-of-oriens-lacunosum-moleculare-cells-during-adolescence-in-rats
#1
Kang Chen, Sakura Nakauchi, Hailing Su, Saki Tanimoto, Katumi Sumikawa
Maternal cigarette smoking during pregnancy and maternal nicotine exposure in animal models are associated with cognitive impairments in offspring. However, the underlying mechanism remains unknown. Oriens-lacunosum moleculare (OLM) cells expressing α2* nicotinic acetylcholine receptors (nAChRs) are an important component of hippocampal circuitry, gating information flow and long-term potentiation (LTP) in the CA1 region. Here we investigated whether early postnatal nicotine exposure alters the normal role of α2*-nAChR-expressing OLM cells during adolescence in rats...
February 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26300744/network-models-provide-insights-into-how-oriens-lacunosum-moleculare-and-bistratified-cell-interactions-influence-the-power-of-local-hippocampal-ca1-theta-oscillations
#2
Katie A Ferguson, Carey Y L Huh, Bénédicte Amilhon, Frédéric Manseau, Sylvain Williams, Frances K Skinner
Hippocampal theta is a 4-12 Hz rhythm associated with episodic memory, and although it has been studied extensively, the cellular mechanisms underlying its generation are unclear. The complex interactions between different interneuron types, such as those between oriens-lacunosum-moleculare (OLM) interneurons and bistratified cells (BiCs), make their contribution to network rhythms difficult to determine experimentally. We created network models that are tied to experimental work at both cellular and network levels to explore how these interneuron interactions affect the power of local oscillations...
2015: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/26082683/novel-markers-for-olm-interneurons-in-the-hippocampus
#3
Sanja Mikulovic, C Ernesto Restrepo, Markus M Hilscher, Klas Kullander, Richardson N Leão
No abstract text is available yet for this article.
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/25769669/inhibitory-control-of-site-specific-synaptic-plasticity-in-a-model-ca1-pyramidal-neuron
#4
Aušra Saudargienė, Bruce P Graham
A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons...
April 2015: Bio Systems
https://www.readbyqxmd.com/read/25721691/a-computational-study-on-how-theta-modulated-inhibition-can-account-for-the-long-temporal-windows-in-the-entorhinal-hippocampal-loop
#5
Vassilis Cutsuridis, Panayiota Poirazi
A recent experimental study (Mizuseki, Sirota, Pastalkova, & Buzsaki, 2009) has shown that the temporal delays between population activities in successive entorhinal and hippocampal anatomical stages are longer (about 70-80ms) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We investigate via computer simulations the mechanisms that give rise to such long temporal delays in the hippocampus structures. A model of the dentate gyrus (DG), CA3 and CA1 microcircuits is presented that uses biophysical representations of the major cell types including granule cells, CA3 and CA1 pyramidal cells (PCs) and six types of interneurons: basket cells (BCs), axo-axonic cells (AACs), bistratified cells (BSCs), oriens lacunosum-moleculare cells (OLMs), mossy cells (MCs) and hilar perforant path associated cells (HC)...
April 2015: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/24978936/intrinsic-mechanisms-stabilize-encoding-and-retrieval-circuits-differentially-in-a-hippocampal-network-model
#6
Ali Hummos, Charles C Franklin, Satish S Nair
Acetylcholine regulates memory encoding and retrieval by inducing the hippocampus to switch between pattern separation and pattern completion modes. However, both processes can introduce significant variations in the level of network activity and potentially cause a seizure-like spread of excitation. Thus, mechanisms that keep network excitation within certain bounds are necessary to prevent such instability. We developed a biologically realistic computational model of the hippocampus to investigate potential intrinsic mechanisms that might stabilize the network dynamics during encoding and retrieval...
December 2014: Hippocampus
https://www.readbyqxmd.com/read/24005295/tuning-local-calcium-availability-cell-type-specific-immobile-calcium-buffer-capacity-in-hippocampal-neurons
#7
Elizabeth A Matthews, Susanne Schoch, Dirk Dietrich
It has remained difficult to ascribe a specific functional role to immobile or fixed intracellular calcium buffers in central neurons because the amount of these buffers is unknown. Here, we explicitly isolated the fixed buffer fraction by prolonged whole-cell patch-clamp dialysis and quantified its buffering capacity in murine hippocampal slices using confocal calcium imaging and the "added-buffer" approach. In dentate granule cells, the calcium binding ratio (κ) after complete washout of calbindin D28k (Cb), κfixed, displayed a substantial value of ∼100...
September 4, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/23042082/olm-interneurons-differentially-modulate-ca3-and-entorhinal-inputs-to-hippocampal-ca1-neurons
#8
Richardson N Leão, Sanja Mikulovic, Katarina E Leão, Hermany Munguba, Henrik Gezelius, Anders Enjin, Kalicharan Patra, Anders Eriksson, Leslie M Loew, Adriano B L Tort, Klas Kullander
The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types has been hampered by the lack of cell-specific tools. We identified a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining transgenic mice and optogenetic tools, we found that OLM cells are important for gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex)...
November 2012: Nature Neuroscience
https://www.readbyqxmd.com/read/23010933/frequency-invariant-temporal-ordering-of-interneuronal-discharges-during-hippocampal-oscillations-in-awake-mice
#9
Csaba Varga, Peyman Golshani, Ivan Soltesz
Endogenous brain rhythms occurring at various frequencies and associated with distinct behavioral states provide multiscale temporal windows that enable cells to time their spiking activity with high precision, which is thought to be important for the coding of information in neuronal circuits. However, although the selective timing of GABAergic inputs to specific spatial domains of principal cells are known to play key roles in network oscillations, the in vivo firing patterns of distinct hippocampal interneurons in awake animals are not known...
October 2, 2012: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/20882544/local-circuitry-involving-parvalbumin-positive-basket-cells-in-the-ca2-region-of-the-hippocampus
#10
Audrey Mercer, Karen Eastlake, Hayley L Trigg, Alex M Thomson
There is a growing recognition that the CA2 region of the hippocampus has its own distinctive properties, inputs, and pathologies. The dendritic and axonal patterns of some interneurons in this region are also strikingly different from those described previously in CA1 and CA3. The local circuitry in this region, however, had yet to be studied in detail. Accordingly, using dual intracellular recordings and biocytin-filling, excitatory and inhibitory connections involving CA2 parvalbumin-positive basket cells were characterized for the first time...
January 2012: Hippocampus
https://www.readbyqxmd.com/read/20421280/differences-in-subthreshold-resonance-of-hippocampal-pyramidal-cells-and-interneurons-the-role-of-h-current-and-passive-membrane-characteristics
#11
Rita Zemankovics, Szabolcs Káli, Ole Paulsen, Tamás F Freund, Norbert Hájos
The intrinsic properties of distinct types of neuron play important roles in cortical network dynamics. One crucial determinant of neuronal behaviour is the cell's response to rhythmic subthreshold input, characterised by the input impedance, which can be determined by measuring the amplitude and phase of the membrane potential response to sinusoidal currents as a function of input frequency. In this study, we determined the impedance profiles of anatomically identified neurons in the CA1 region of the rat hippocampus (pyramidal cells as well as interneurons located in the stratum oriens, including OLM cells, fast-spiking perisomatic region-targeting interneurons and cells with axonal arbour in strata oriens and radiatum)...
June 15, 2010: Journal of Physiology
https://www.readbyqxmd.com/read/19489002/encoding-and-retrieval-in-a-model-of-the-hippocampal-ca1-microcircuit
#12
Vassilis Cutsuridis, Stuart Cobb, Bruce P Graham
It has been proposed that the hippocampal theta rhythm (4-7 Hz) can contribute to memory formation by separating encoding (storage) and retrieval of memories into different functional half-cycles (Hasselmo et al. (2002) Neural Comput 14:793-817). We investigate, via computer simulations, the biophysical mechanisms by which storage and recall of spatio-temporal input patterns are achieved by the CA1 microcircuitry. A model of the CA1 microcircuit is presented that uses biophysical representations of the major cell types, including pyramidal (P) cells and four types of inhibitory interneurons: basket (B) cells, axo-axonic (AA) cells, bistratified (BS) cells and oriens lacunosum-moleculare (OLM) cells...
March 2010: Hippocampus
https://www.readbyqxmd.com/read/19276474/olm-interneurons-are-transiently-recruited-into-field-gamma-oscillations-evoked-by-brief-kainate-pressure-ejections-onto-area-ca1-in-mice-hippocampal-slices
#13
E Kipiani
Oscillations (30-100 Hz) are correlated with the cognitive functions of the brain. In the hippocampus interactions between perisomatic and trilaminar interneurons with pyramidal cells are thought to underlie generation of field gamma oscillations. In area CA3 OLM interneurons receive synaptic input in gamma range but generate action potential (AP) output in theta band and are involved in theta oscillations synchronized along the longitudinal axis of the hippocampus. In slice preparations of CA3 area the spike timing of OLM cells could be modulated by carbachole induced gamma oscillations, although their firing rates are limited to theta frequency...
February 2009: Georgian Medical News
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