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Randall Haas, Ioana C Stefanescu, Alexander Garcia-Putnam, Mark S Aldenderfer, Mark T Clementz, Melissa S Murphy, Carlos Viviano Llave, James T Watson
High-elevation environments above 2500 metres above sea level (m.a.s.l.) were among the planet's last frontiers of human colonization. Research on the speed and tempo of this colonization process is active and holds implications for understanding rates of genetic, physiological and cultural adaptation in our species. Permanent occupation of high-elevation environments in the Andes Mountains of South America tentatively began with hunter-gatherers around 9 ka according to current archaeological estimates, though the timing is currently debated...
June 2017: Royal Society Open Science
Fernanda de Paula Rossini, Denise de Andrade, Lissandra Chaves de Sousa Santos, Adriano Menis Ferreira, Caroline Tieppo, Evandro Watanabe
Objective: to evaluate the use of peripheral venous catheters based on microbiological analysis of devices (dressing and three-way stopcocks) and thus contribute to the prevention and infection control. Methods: this was a prospective study of microbiological analysis of 30 three-way stopcocks (external surfaces and lumens) and 30 dressing used in maintaining the peripheral venous catheters of hospitalized adult patients. Results: all external surfaces, 40% of lumens, and 86...
May 15, 2017: Revista Latino-americana de Enfermagem
Osmel La-Llave-León, Edna M Méndez-Hernández, Francisco X Castellanos-Juárez, Eloísa Esquivel-Rodríguez, Fernando Vázquez-Alaniz, Ada Sandoval-Carrillo, Gonzalo García-Vargas, Jaime Duarte-Sustaita, Jorge L Candelas-Rangel, José M Salas-Pacheco
Blood lead levels (BLLs) and delta-aminolevulinic acid dehydratase (ALAD) activity are considered biomarkers of lead exposure and lead toxicity, respectively. The present study was designed to investigate the association between BLLs and ALAD activity in pregnant women from Durango, Mexico. A total of 633 pregnant women aged 13-43 years participated in this study. Blood lead was measured by a graphite furnace atomic absorption spectrometer. ALAD activity was measured spectrophotometrically. Mean blood lead was 2...
April 18, 2017: International Journal of Environmental Research and Public Health
Alicia Gutierrez-Valencia, Omar J Benmarzouk-Hidalgo, Silvia Llaves, Tamara Fernandez-Magdaleno, Nuria Espinosa, Pompeyo Viciana, Luis F Lopez-Cortes
Objectives: To evaluate if there are significant drug-drug interactions between cobicistat-boosted elvitegravir and 800 mg darunavir once daily taken simultaneously, as has been suggested previously. Methods: The study population consisted of three groups of unselected volunteers taking a regimen of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate (150, 150, 200 and 300 mg, respectively) co-formulated in a single tablet plus 800 mg darunavir (group A); only co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate (group B); and cobicistat-boosted darunavir (800 mg darunavir + 150 mg cobicistat) plus two nucleos(t)ide analogues (group C)...
March 1, 2017: Journal of Antimicrobial Chemotherapy
Osmel La-Llave-León, José Manuel Salas Pacheco, Sergio Estrada Martínez, Eloísa Esquivel Rodríguez, Francisco X Castellanos Juárez, Ada Sandoval Carrillo, Angélica María Lechuga Quiñones, Fernando Vázquez Alanís, Gonzalo García Vargas, Edna Madai Méndez Hernández, Jaime Duarte Sustaita
BACKGROUND: Pregnant women exposed to lead are at risk of suffering reproductive damages, such as miscarriage, preeclampsia, premature delivery and low birth weight. Despite that the workplace offers the greatest potential for lead exposure, there is relatively little information about occupational exposure to lead during pregnancy. This study aims to assess the association between blood lead levels and occupational exposure in pregnant women from Durango, Mexico. METHODS: A cross-sectional study was carried out in a population of 299 pregnant women...
December 7, 2016: BMC Public Health
Tuane S DE Oliveira, Aline B Bombo, Adriana S S DE Oliveira, Vera L Garcia, Beatriz Appezzato-DA-Glória
Aldama arenaria and A. robusta are morphologically similar aromatic species that have seasonal development. The yield and chemical composition of essential oils from aerial and underground vegetative organs of these species were compared to verify the production of volatile metabolites in flowering and dormant phases of development and to identify if there are unique compounds for either species. The major compound in the essential oils from A. arenaria leaves was palustrol (16.22%) and for aerial stems was limonene (15...
2016: Anais da Academia Brasileira de Ciências
Daniel Hirshberg, Daniel Sharon, Ezequiel De La Llave, Michal Afri, Aryeh A Frimer, Won-Jin Kwak, Yang-Kook Sun, Doron Aurbach
Aprotic Li-O2 battery is an exciting concept. The enormous theoretical energy density and cell assembly simplicity make this technology very appealing. Nevertheless, the instability of the cell components, such as cathode, anode, and electrolyte solution during cycling, does not allow this technology to be fully commercialized. One of the intrinsic challenges facing researchers is the use of lithium metal as an anode in Li-O2 cells. The high activity toward chemical moieties and lack of control of the dissolution/deposition processes of lithium metal makes this anode material unreliable...
October 27, 2016: ACS Applied Materials & Interfaces
Danh Truong, Julieann Puleo, Alison Llave, Ghassan Mouneimne, Roger D Kamm, Mehdi Nikkhah
In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative microfluidic chip allowing side-by-side positioning of 3D hydrogel-based matrices. We were able to (1) create a dual matrix architecture that extended in a continuous manner, thus allowing invasion from one 3D matrix to another, and (2) establish distinct regions of tumor and stroma cell/ECM compositions, with a clearly demarcated tumor invasion front, thus allowing us to quantitatively analyze progression of cancer cells into the stroma at a tissue or single-cell level...
September 28, 2016: Scientific Reports
Jose Manuel Salas-Pacheco, Diana Lelidett Lourenco-Jaramillo, Edna Madai Mendez-Hernandez, Ada Agustina Sandoval-Carrillo, Yessica Ivonne Hernandez Rayon, Osmel La Llave-Leon, Marisela Aguilar-Duran, Marcos Alonso Lopez-Terrones, Marcelo Barraza-Salas, Fernando Vazquez-Alaniz
OBJECTIVE: The aim of this study was to determine malondialdehyde (MDA) concentration as an oxidative stress marker and total antioxidant capacity (TAC) in pregnancy before and after perinatal event. METHODS: This study was performed on 200 healthy full-term pregnant women admitted to pregnancy resolution in Maternal-Child Hospital of Durango, Mexico. Oxidative stress and TAC were assessed through detection of lipid peroxidation by quantitation of thiobarbituric acid-reactive substances (TBARS) and TAC through ferric reducing ability of the plasma (FRAP)...
August 2017: Journal of Maternal-fetal & Neonatal Medicine
César Llave
Upon infection plant viruses modulate cellular functions and resources to survive and reproduce. Plant cells in which the virus is replicating are transformed into strong metabolic sinks. This conversion gives rise to a massive reprogramming of plant primary metabolism. Such a metabolic shift involves perturbations in carbohydrates, amino acids and lipids that eventually lead to increase respiration rates, and/or decrease in photosynthetic activity. By doing so, plants provide metabolic acclimation against cellular stress and meet the increased demand for energy needed to sustain virus multiplication and defense responses against viruses...
August 2016: Current Opinion in Virology
Edward Claro Mader, Annie Cielo Llave Mader
Sleep continues to perplex scientists and researchers. Despite decades of sleep research, we still lack a clear understanding of the biological functions and evolution of sleep. In this review, we will examine sleep from a functional and phylogenetic perspective and describe some important conceptual gaps in understanding sleep. Classical theories of the biology and evolution of sleep emphasize sensory activation, energy balance, and metabolic homeostasis. Advances in electrophysiology, functional neuroimaging, and neuroplasticity allow us to view sleep within the framework of neural dynamics...
August 15, 2016: Journal of the Neurological Sciences
Jose V León-Hernández, Aitor Martín-Pintado-Zugasti, Laura G Frutos, Isabel M Alguacil-Diego, Ana I de la Llave-Rincón, Josue Fernandez-Carnero
Background: Dry needling (DN) and percutaneous electrical nerve stimulation (PENS) are widely used techniques in the treatment of myofascial pain. Objective: To investigate the immediate and short-term effects of the combination of DN and PENS compared to DN alone on the upper trapezius muscle. Method: This is a 72-hour follow-up single-blinded randomized controlled trial. Sixty-two volunteer patients with chronic myofascial neck pain with active Myofascial Trigger Points (MTrPs) in the upper trapezius muscle were recruited...
July 11, 2016: Brazilian Journal of Physical Therapy
Ada Sandoval-Carrillo, Edna M Méndez-Hernández, Elizabeth I Antuna-Salcido, Sergio M Salas-Pacheco, Fernando Vázquez-Alaniz, Alfredo Téllez-Valencia, Marisela Aguilar-Durán, Marcelo Barraza-Salas, Francisco X Castellanos-Juárez, Osmel La Llave-León, José M Salas-Pacheco
BACKGROUND: Exposure to arsenic in drinking water has been associated with various complications of pregnancy including fetal loss, low birth weight, anemia, gestational diabetes and spontaneous abortion. However, to date, there are no studies evaluating its possible association with preeclampsia. METHODS: This case-control study involved 104 preeclamptic and 202 healthy pregnant women. The concentrations of arsenic in drinking water and urine were measured using a Microwave Plasma-Atomic Emission Spectrometer...
2016: BMC Pregnancy and Childbirth
Ezequiel de la Llave, Valentina Borgel, Kang-Joon Park, Jang-Yeon Hwang, Yang-Kook Sun, Pascal Hartmann, Frederick-Francois Chesneau, Doron Aurbach
The electrochemical behavior of Na-ion and Li-ion full cells was investigated, using hard carbon as the anode material, and NaNi0.5Mn0.5O2 and LiNi0.5Mn0.5O2 as the cathodes. A detailed description of the structure, phase transition, electrochemical behavior and kinetics of the NaNi0.5Mn0.5O2 cathodes is presented, including interesting comparison with their lithium analogue. The critical effect of the hard carbon anodes pretreatment in the total capacity and stability of full cells is clearly demonstrated...
January 27, 2016: ACS Applied Materials & Interfaces
Ezequiel de la Llave, Santiago E Herrera, Catherine Adam, Lucila P Méndez De Leo, Ernesto J Calvo, Federico J Williams
The molecular and electronic structure of Os(II) complexes covalently bonded to self-assembled monolayers (SAMs) on Au(111) surfaces was studied by means of polarization modulation infrared reflection absorption spectroscopy, photoelectron spectroscopies, scanning tunneling microscopy, scanning tunneling spectroscopy, and density functional theory calculations. Attachment of the Os complex to the SAM proceeds via an amide covalent bond with the SAM alkyl chain 40° tilted with respect to the surface normal and a total thickness of 26 Å...
November 14, 2015: Journal of Chemical Physics
Dilia Aguirre-Olivas, Gabriel Mellado-Villaseñor, David Sánchez-de-la-Llave, Victor Arrizón
We discuss the generation of Hermite-Gauss and Ince-Gauss beams employing phase elements whose transmittances coincide with the phase modulations of such beams. A scaled version of the desired field appears, distorted by marginal optical noise, at the element's Fourier domain. The motivation to perform this study is that, in the context of the proposed approach, the desired beams are generated with the maximum possible efficiency. A disadvantage of the method is the distortion of the desired beams by the influence of several nondesired beam modes generated by the phase elements...
October 1, 2015: Applied Optics
César Fernández-de-Las Peñas, Ricardo Ortega-Santiago, Ana I de la Llave-Rincón, Almudena Martínez-Perez, Homid Fahandezh-Saddi Díaz, Javier Martínez-Martín, Juan A Pareja, Maria L Cuadrado-Pérez
UNLABELLED: This randomized clinical trial investigated the effectiveness of surgery compared with physical therapy consisting of manual therapies including desensitization maneuvers in carpal tunnel syndrome (CTS). The setting was a public hospital and 2 physical therapy practices in Madrid, Spain. One hundred twenty women with CTS were enrolled between February 2013 and January 2014, with 1-year follow-up completed in January 2015. Interventions consisted of 3 sessions of manual therapies including desensitization maneuvers of the central nervous system (physical therapy group, n = 60) or decompression/release of the carpal tunnel (surgical group, n = 60)...
November 2015: Journal of Pain: Official Journal of the American Pain Society
Tadashi Yamashita, Sherri Ann Suplido, Cecilia Llave, Maria Teresa R Tuliao, Yuko Tanaka, Hiroya Matsuo
BACKGROUND: Given the shortage of medical professionals in the Philippines, Barangay Health Workers (BHWs) may play a role in providing postpartum healthcare services. However, as there are no reports regarding BHW activities in postpartum healthcare, we conducted this study to understand postpartum healthcare services and to explore the challenges and motivations of maternal health service providers. METHODS: Focus group interview (FGI) of 13 participants was conducted as qualitative research methodology at Muntinlupa City...
June 2015: Tropical Medicine and Health
Mario Téllez-García, Ana I de-la-Llave-Rincón, Jaime Salom-Moreno, Maria Palacios-Ceña, Ricardo Ortega-Santiago, César Fernández-de-Las-Peñas
The objective of the current study was to determine the short-term effects of trigger point dry needling (TrP-DN) alone or combined with neuroscience education on pain, disability, kinesiophobia and widespread pressure sensitivity in patients with mechanical low back pain (LBP). Twelve patients with LBP were randomly assigned to receive either TrP-DN (TrP-DN) or TrP-DN plus neuroscience education (TrP-DN + EDU). Pain intensity (Numerical Pain Rating Scale, 0-10), disability (Roland-Morris Disability Questionnaire-RMQ-, Oswestry Low Back Pain Disability Index-ODI), kinesiophobia (Tampa Scale of Kinesiophobia-TSK), and pressure pain thresholds (PPT) over the C5-C6 zygapophyseal joint, transverse process of L3 vertebra, second metacarpal, and tibialis anterior muscle were collected at baseline and 1-week after the intervention...
July 2015: Journal of Bodywork and Movement Therapies
Oscar Zenón Rosas-Guerra, Jorge Alfonso Pérez-Castro y Vázquez, Gumaro Hugolino Andrade-López, Fernando Vera-Rodríguez, Heriberto Garza-de la Llave
BACKGROUND: Collision tumours are extremely rare. They are defined by the presence of two tumours of different histological origin in the same organ. CLINICAL CASE: A 71 year old female with history of a carcinoid tumour removed 20 years ago without any recurrence. The patient was admitted with intestinal occlusion symptoms secondary to a right flank abdominal tumour. An exploratory laparotomy was performed, removing the tumor and applying optimal debulking. The histopathological study reported bilateral ovary adenocarcinoma, as well as metastatic collision tumour of two histological types: well differentiated adenocarcinoma and a mixed malignant mesodermic Mullerian tumor...
May 2015: Cirugia y Cirujanos
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