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https://www.readbyqxmd.com/read/29750179/evolving-management-and-improving-outcomes-of-pregnancy-associated-spontaneous-coronary-artery-dissection-p-scad-a-systematic-review
#1
Elizabeth D Paratz, Chien Kao, Andrew I MacIsaac, Jithendra Somaratne, Robert Whitbourn
Background: Pregnancy-associated spontaneous coronary artery dissection (P-SCAD) is defined as SCAD occurring during pregnancy or within 3 months post-partum. Earlier systematic reviews have suggested a high maternal and foetal mortality rate. We undertook a structured systematic review of P-SCAD demographics, management and maternal and foetal outcomes. Methods: Case study identification was conducted according to PRISMA guidelines, with screening of all published P-SCAD cases not meeting pre-defined exclusion criteria...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29747971/a-taste-of-things-to-come
#2
EDITORIAL
Glenis K Scadding
No abstract text is available yet for this article.
May 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29707563/copd-time-to-improve-its-taxonomy
#3
Bartolomé R Celli, Alvar Agustí
Due to well-conducted epidemiological studies and advances in genetics, molecular biology, translational research, the advent of computed tomography of the lungs and bioinformatics, the diagnosis of chronic obstructive pulmonary disease (COPD) as a single entity caused by susceptibility to cigarette smoke is no longer tenable. Furthermore, the once-accepted concept that COPD results from a rapid and progressive loss of lung function over time is not true for a sizeable proportion of adults with the disease...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29691183/intravascular-imaging-for-cardiac-arrest-with-normal-coronary-arteriography
#4
Tawfiq Choudhury, Amir Solomonica, Rodrigo Bagur, Shahar Lavi
Spontaneous coronary artery dissection (SCAD) is an under-recognised presentation of acute coronary syndrome. A high index of suspicion is essential. If diagnostic doubt is high, intracoronary imaging, performed carefully, can be useful, although it can result in worsening of the clinical condition. The current report exemplifies the complexity of diagnosis and management of SCAD in a patient with out-of-hospital cardiac arrest and non-diagnostic angiography.
April 14, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29689755/robust-sparse-accelerated-failure-time-model-for-survival-analysis
#5
Haiwei Shen, Hua Chai, Meiping Li, Zhiming Zhou, Yong Liang, Ziyi Yang, Haihui Huang, Xiaoying Liu, Bowen Zhang
To identify the bio-mark genes related to disease with high dimension and low sample size gene expression data, various regression approaches with different regularization methods have been proposed to solve this problem. Nevertheless, high-noises in biological data significantly reduce the performances of methods. The accelerated failure time (AFT) modelwas designed for gene selection and survival time estimation in cancer survival analysis. In this article, we proposed a novel robust sparse accelerated failure time model (RS-AFT) through combining the least absolute deviation (LAD) and Lq regularization...
April 10, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29686789/a-case-of-spontaneous-coronary-artery-dissection-presenting-with-acute-anterior-wall-myocardial-infarction-in-a-young-adult-male-an-increasingly-recognized-rare-disease
#6
Mohamed Taha, Htun Latt, Jaafar Al-Khafaji, Mohamed Ali, Richard Seher
Background : Spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction and sudden death. Although some correlations have been noted in relation to aetiology, no direct causes have been identified in a large number of patients. Most of the patients are women in peripartum period or of childbearing age, with few if any risk factors for coronary heart disease. In men, however, risk factors for atherosclerosis are more prevalent in cases of SCAD Case report : We report a case of a 43-years-old healthy male, with no known risk factors, who presented with ischemic chest pain and elevated troponin levels...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686623/ticagrelor-improves-endothelial-function-by-decreasing-circulating-epidermal-growth-factor-egf
#7
Francesco Vieceli Dalla Sega, Francesca Fortini, Giorgio Aquila, Rita Pavasini, Simone Biscaglia, Davide Bernucci, Annamaria Del Franco, Elisabetta Tonet, Paola Rizzo, Roberto Ferrari, Gianluca Campo
Ticagrelor is one of the most powerful P2Y12 inhibitor. We have recently reported that, in patients with concomitant Stable Coronary Artery Disease (SCAD) and Chronic Obstructive Pulmonary Disease (COPD) undergoing percutaneous coronary intervention (PCI), treatment with ticagrelor, as compared to clopidogrel, is associated with an improvement of the endothelial function (Clinical Trial NCT02519608). In the present study, we showed that, in the same population, after 1 month treatment with ticagrelor, but not with clopidogrel, there is a decrease of the circulating levels of epidermal growth factor (EGF) and that these changes in circulating levels of EGF correlate with on-treatment platelet reactivity...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29678161/an-unusually-high-frequency-of-scad-deficiency-caused-by-two-pathogenic-variants-in-the-acads-gene-and-its-relationship-to-the-ethnic-structure-in-slovakia
#8
Jana Lisyová, Ján Chandoga, Petra Jungová, Marcel Repiský, Mária Knapková, Martina Machková, Svetozár Dluholucký, Darina Behúlová, Jana Šaligová, Ľudmila Potočňáková, Miroslava Lysinová, Daniel Böhmer
BACKGROUND: Short-chain acyl-CoA dehydrogenase deficiency (SCADD) represents a rare autosomal recessive inborn metabolic disorder of mitochondrial β-oxidation of monocarboxylic acids. Clinical symptoms can vary from a severe life-threatening condition to an asymptomatic state, reported in the majority of cases. Since the expansion of newborn screenings, more than three hundred probands were admitted for molecular-genetic analysis, most selected because of elevated values of C4-acylcarnitine detected in newborn screenings in Slovakia...
April 20, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29650765/prospective-cardiovascular-genetics-evaluation-in-spontaneous-coronary-artery-dissection
#9
M Ihsan Kaadan, Carolyn MacDonald, Francesca Ponzini, Jessica Duran, Kelsey Newell, Linda Pitler, Angela Lin, Ido Weinberg, Malissa J Wood, Mark E Lindsay
BACKGROUND: Previous studies describing genetics evaluation in spontaneous coronary artery dissection (SCAD) have been retrospective in nature or presented as single case reports. As part of a dedicated clinical program, we evaluated patients in cardiovascular genetics clinic to determine the role of genetically triggered vascular disease and genetic testing in SCAD. METHODS AND RESULTS: Patient data were entered prospectively into the Massachusetts General Hospital SCAD registry database from July 2013 to September 2017...
April 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29643721/scalable-bayesian-variable-selection-using-nonlocal-prior-densities-in-ultrahigh-dimensional-settings
#10
Minsuk Shin, Anirban Bhattacharya, Valen E Johnson
Bayesian model selection procedures based on nonlocal alternative prior densities are extended to ultrahigh dimensional settings and compared to other variable selection procedures using precision-recall curves. Variable selection procedures included in these comparisons include methods based on g -priors, reciprocal lasso, adaptive lasso, scad, and minimax concave penalty criteria. The use of precision-recall curves eliminates the sensitivity of our conclusions to the choice of tuning parameters. We find that Bayesian variable selection procedures based on nonlocal priors are competitive to all other procedures in a range of simulation scenarios, and we subsequently explain this favorable performance through a theoretical examination of their consistency properties...
April 2018: Statistica Sinica
https://www.readbyqxmd.com/read/29618370/myeloperoxidase-level-and-inflammatory-markers-and-lipid-and-lipoprotein-parameters-in-stable-coronary-artery-disease
#11
Elżbieta Kimak, Bartosz Zięba, Dariusz Duma, Janusz Solski
BACKGROUND: Myeloperoxidase (MPO) impairing endothelial functions. We investigated whether increasing concentration of myeloperoxidase (MPO) and inflammatory markers induce progression and incident acute coronary syndrome (ACS) in stable coronary artery disease (SCAD) patients. Therefore, the concentration of MPO, lipids, lipoproteins (apo(apolipoprotein) AI, apoB, lipoprotein associated phospholipase A2 (LpPLA2) level), inflammatory markers (high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α), interleukine-6 (IL-6) concentration) were examined...
April 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29563379/rapid-healing-of-a-spontaneous-coronary-artery-dissection-detected-by-computed-tomography-angiography
#12
Koyu Sakai, Yohei Kobayashi, Shinichi Shirai, Kenji Ando
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and little is known about characteristics, treatment, and follow-up of patients with SCAD. Computed tomography angiography (CTA) plays an important role in the diagnosis and management of SCAD. Herein, we describe a case of a patient with SCAD who underwent successful conservative management, and in whom CTA was able to detect rapid healing of the dissection, 4.5 hours post-dissection.
March 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29549452/spontaneous-coronary-artery-dissection-diagnosis-and-management
#13
REVIEW
Ilhwan Yeo, Dmitriy N Feldman, Luke K Kim
PURPOSE OF REVIEW: Spontaneous coronary artery dissection (SCAD) is a non-iatrogenic and non-traumatic separation of the coronary arterial wall. While SCAD represents an important cause of myocardial infarction, optimal diagnostic and therapeutic options remain challenging. We sought to review recent studies and provide an update on diagnosis and management of SCAD. RECENT FINDINGS: Coronary angiography is the first-line diagnostic modality for SCAD, with three angiographic features commonly observed in SCAD: type 1 (pathognomonic angiographic appearance with contrast staining of the arterial wall), type 2 (long coronary stenosis), and type 3 (focal tubular stenosis)...
March 17, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29537415/sir-winston-churchill-treatment-for-pneumonia-in-1943-and-1944
#14
J A Vale, J W Scadding
This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29519241/clinical-and-genetic-characteristics-of-patients-with-fatty-acid-oxidation-disorders-identified-by-newborn-screening
#15
Eungu Kang, Yoon-Myung Kim, Minji Kang, Sun-Hee Heo, Gu-Hwan Kim, In-Hee Choi, Jin-Ho Choi, Han-Wook Yoo, Beom Hee Lee
BACKGROUND: Fatty acid oxidation disorders (FAODs) include more than 15 distinct disorders with variable clinical manifestations. After the introduction of newborn screening using tandem mass spectrometry, early identification of FAODs became feasible. This study describes the clinical, biochemical and molecular characteristics of FAODs patients detected by newborn screening (NBS) compared with those of 9 patients with symptomatic presentations. METHODS: Clinical and genetic features of FAODs patients diagnosed by NBS and by symptomatic presentations were reviewed...
March 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29502960/spontaneous-coronary-artery-dissection-and-takotsubo-syndrome-an-often-overlooked-association-review
#16
REVIEW
Shams Y-Hassan
Spontaneous coronary artery dissection (SCAD) and takotsubo syndrome (TS) are two cardiovascular syndromes with predilection for women. Both conditions may be preceded by an emotional stress or, for the affected individual, an unusual severe physical exercise. "Restitution ad integrum" occurs in most cases suffering from SCAD or TS with complete angiographic resolution of the dissected vessel and left ventricular dysfunction respectively. Recently, many cases, which were initially diagnosed as TS because of typical left ventricular ballooning pattern showed to have SCAD, have been reported; these cases were deemed to be "SCAD misdiagnosed as TS"...
February 8, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29489465/renin-angiotensin-system-blockade-reduces-cardiovascular-events-in-nonheart-failure-stable-patients-with-prior-coronary-intervention
#17
Young Choi, Sungmin Lim, Kwan Yong Lee, Ha-Wook Park, Jaeho Byeon, Byung-Hee Hwang, Jin Jin Kim, Yong-Seog Oh, Ho-Joong Youn, Wook Sung Jung, Ki-Bae Seung, Kiyuk Chang
BACKGROUND: The effects of renin-angiotensin system (RAS) blockade on the clinical outcome in patients with stable coronary artery disease (SCAD) are conflicting. We evaluated the long-term effects of RAS blockers (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker) on the clinical outcomes in patients with SCAD without heart failure (HF) who underwent percutaneous coronary intervention (PCI) with drug-eluting stent using a large-scale, multicenter, prospective cohort registry...
February 27, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29481627/european-society-of-cardiology-acute-cardiovascular-care-association-scad-study-group-a-position-paper-on-spontaneous-coronary-artery-dissection
#18
David Adlam, Fernando Alfonso, Angela Maas, Christiaan Vrints
No abstract text is available yet for this article.
February 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29478722/spontaneous-dissection-in-the-left-main-coronary-artery
#19
Peiren Shan, Weijian Huang, Rukhsaar Hoosen, Changzuan Zhou, Gary S Mintz, Guosheng Fu
We present two cases of spontaneous left main stem coronary artery dissection. One was underdiagnosed with suboptimal percutaneous coronary artery intervention followed by acute vessel occlusion again during the hospitalization. The other one was identified and confirmed by intravascular ultrasound, followed by conservative medical treatment, with completed healing of SCAD during two-month follow up.
May 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29474376/using-single-index-odes-to-study-dynamic-gene-regulatory-network
#20
Qi Zhang, Yao Yu, Jun Zhang, Hua Liang
With the development of biotechnology, high-throughput studies on protein-protein, protein-gene, and gene-gene interactions become possible and attract remarkable attention. To explore the interactions in dynamic gene regulatory networks, we propose a single-index ordinary differential equation (ODE) model and develop a variable selection procedure. We employ the smoothly clipped absolute deviation penalty (SCAD) penalized function for variable selection. We analyze a yeast cell cycle gene expression data set to illustrate the usefulness of the single-index ODE model...
2018: PloS One
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