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https://www.readbyqxmd.com/read/28448133/design-of-novel-exendin-based-dual-glucagon-like-peptide-1-glp-1-glucagon-receptor-agonists
#1
Andreas Evers, Torsten Haack, Martin Lorenz, Martin Bossart, Ralf Elvert, Bernd Henkel, Siegfried Stengelin, Michael Kurz, Maike Glien, Angela Dudda, Katrin Lorenz, Dieter Kadereit, Michael Wagner
Dual activation of the glucagon-like peptide 1 (GLP-1) and glucagon receptor has the potential to lead to a novel therapy principle for the treatment of diabesity. Here, we report a series of novel peptides with dual activity on these receptors that were discovered by rational design. Based on sequence analysis and structure-based design, structural elements of glucagon were engineered into the selective GLP-1 receptor agonist exendin-4, resulting in hybrid peptides with potent dual GLP-1/glucagon receptor activity...
April 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28448086/effects-of-running-wheel-activity-and-dietary-hmb-and-%C3%AE-alanine-co-supplementation-on-muscle-quality-in-aged-male-rats
#2
D W Russ, C Acksel, K W McCorkle, N K Edens, S M Garvey
OBJECTIVE: Loss of skeletal muscle function is linked to increased risk for loss of health and independence in older adults. Dietary interventions that can enhance aging muscle function, alone or in combination with exercise, may offer an effective way to reduce these risks. The goal of this study was to evaluate the muscular effects of beta-hydroxy-beta-methylbutyrate (HMB) and beta-alanine (β-Ala) co-supplementation in aged Sprague-Dawley rats with voluntary access to running wheels (RW)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28448079/relationship-between-breakfast-skipping-and-obesity-among-elderly-cross-sectional-analysis-of-the-heijo-kyo-study
#3
N Otaki, K Obayashi, K Saeki, M Kitagawa, N Tone, N Kurumatani
OBJECTIVE: Breakfast skipping is reported to be associated with obesity in children and younger populations; however, few studies report the association among elderly. The purpose of this study was to investigate the relationships between breakfast skipping and obesity prevalence among elderly. DESIGN: Cross-sectional study. SETTING: Community-dwelling elderly in Nara, Japan. PARTICIPANTS: 1052 elderly participants (mean age: 71...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447071/the-effects-of-reduced-rpd3-levels-on-fly-physiology
#4
Jared K Woods, Tahereh Ziafazeli, Blanka Rogina
BACKGROUND: Rpd3 is a conserved histone deacetylase that removes acetyl groups from lysine residues within histones and other proteins. Reduction or inhibition of Rpd3 extends longevity in yeast, worms, and flies. Previous studies in flies suggest an overlap with the mechanism of lifespan extension by dietary restriction. However, the mechanism of rpd3's effects on longevity remains unclear. OBJECTIVES: In this study we investigated how rpd3 reduction affects fly spontaneous physical activity, fecundity, and stress resistance...
March 31, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/28446498/diet-quality-of-us-adolescents-during-the-transition-to-adulthood-changes-and-predictors
#5
Leah M Lipsky, Tonja R Nansel, Denise L Haynie, Danping Liu, Kaigang Li, Charlotte A Pratt, Ronald J Iannotti, Katherine W Dempster, Bruce Simons-Morton
Background: Influences on diet quality during the transition from adolescence to adulthood are understudied.Objective: This study examined association of 3 diet-quality indicators-Healthy Eating Index-2010 (HEI), Whole Plant Foods Density (WPF), and Empty Calories (EC; the percentage of calories from discretionary solid fat, added sugar and alcohol)-with lifestyle behaviors, baseline weight status, and sociodemographic characteristics in US emerging adults.Design: Data come from the first 4 waves (annual assessments) of the NEXT Plus Study, a population-based cohort of 10th graders enrolled in 2010 (n = 566)...
April 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28446423/evaluation-of-a-mindfulness-based-mobile-app-aimed-at-promoting-awareness-of-weight-related-behaviors-in-adolescents-a-pilot-study
#6
Tami Turner, Melanie Hingle
BACKGROUND: Mindfulness-based interventions are reported to be highly acceptable and have positive effects on youth, yet most are clinic- or school-based aimed at emotional regulation or academic performance. To provide flexible program delivery, we developed and tested a standalone mindfulness-based app aimed at improving weight-related behaviors (eg, diet, physical activity, sleep) in adolescents. OBJECTIVE: Our objective was to assess the feasibility, acceptability, and utility of a mindfulness-based mobile app...
April 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28444534/metabolic-factors-anthropometric-measures-diet-and-physical-activity-in-long-term-breast-cancer-survivors-change-from-diagnosis-and-comparison-to-non-breast-cancer-controls
#7
Ana Elisa Lohmann, Marguerite Ennis, Sara K Taylor, Pamela J Goodwin
PURPOSE: We studied metabolic factors, diabetes, and anthropometric measurements at diagnosis and long-term follow-up (LTFU), mean 12.5 years post-diagnosis, in breast cancer (BC) survivors, and compared their status at LTFU to that of age-matched women without BC. Diet and physical activity were also assessed. METHOD: 535 non-diabetic BC patients treated at three University of Toronto hospitals were followed prospectively; 285 surviving patients, without distant recurrence, participated in a LTFU study...
April 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28443607/novel-approaches-for-the-promotion-of-physical-activity-and-exercise-for-prevention-and-management-of-type-2-diabetes
#8
REVIEW
R Arena, M Sagner, N M Byrne, A D Williams, A McNeil, S J Street, A P Hills
Despite increased evidence for the importance of lifestyle modification, physical activity and diet in diabetes prevention and management, habitual physical activity levels have declined in recent decades in China and India. Further, other risk factors for type 2 diabetes, including overweight, obesity and physical inactivity, have also worsened. Here we present evidence for the importance of physical activity and exercise in the amelioration of type 2 diabetes and propose a novel approach to address the challenge of improving lifestyle behaviors in China and India-Movement is Medicine and a P4 (predictive, preventive, personalized and participatory) approach...
April 26, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28443489/relationship-between-volition-physical-activity-and-weight-loss-maintenance-study-rationale-design-methods-and-baseline-characteristics
#9
Sune Dandanell, Anne-Marie Elbe, Gertrud Pfister, Peter Elsborg, Jørn W Helge
AIMS: To investigate the relationship between volition, physical activity and weight loss maintenance. METHODS: We recruited 84 sedentary (maximal oxygen uptake: 25 ± 5 ml/min), overweight and obese (Body mass index (BMI) 38 ± 7 m/h(2), fat 44 ± 7 %) women ( n = 55) and men ( n = 29) for an interdisciplinary prospective study with follow-up. The change in lifestyle and weight loss is promoted via a 3-month intensive lifestyle intervention at a private health school...
May 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28443486/repeated-lifestyle-interventions-lead-to-progressive-weight-loss-a-retrospective-review-chart-study
#10
Sune Dandanell, Christian Ritz, Elisabeth Verdich, Flemming Dela, Jørn W Helge
AIMS: This study aimed to investigate whether repeated lifestyle interventions lead to progressive weight loss or to weight cycling. METHODS: A retrospective review chart study with follow-up on 2120 participants (mean±SD age 36±15 years; body weight 116±28 kg; fat 43±6%). All had participated in one to four 11-12 week lifestyle interventions (residential weight loss programme, mixed activities). Weight loss was promoted through a hypocaloric diet (-500 to -700 kcal/day) and daily physical activity (1-3 hours/day)...
May 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28442927/mechanical-factors-and-vitamin-d-deficiency-in-schoolchildren-with-low-back-pain-biochemical-and-cross-sectional-survey-analysis
#11
Ahmad H Alghadir, Sami A Gabr, Einas S Al-Eisa
OBJECTIVE: This study was designed to evaluate the role of vitamin D, muscle fatigue biomarkers, and mechanical factors in the progression of low back pain (LBP) in schoolchildren. BACKGROUND: Children and adolescents frequently suffer from LBP with no clear clinical causes, and >71% of schoolchildren aged 12-17 years will show at least one episode of LBP. MATERIALS AND METHODS: A total of 250 schoolchildren aged 12-16 years were randomly enrolled in this study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28442452/homestyles-a-web-based-childhood-obesity-prevention-program-for-families-with-preschool-children-protocol-for-a-randomized-controlled-trial
#12
Carol Byrd-Bredbenner, Jennifer Martin-Biggers, Mallory Koenings, Virginia Quick, Nobuko Hongu, John Worobey
BACKGROUND: The home environment is where young children spend most of their time, and is critically important to supporting behaviors that promote health and prevent obesity. However, the home environment and lifestyle patterns remain understudied, and few interventions have investigated parent-led makeovers designed to create home environments that are supportive of optimal child health and healthy child weights. OBJECTIVE: The aim of the HomeStyles randomized controlled trial (RCT) is to determine whether the Web-based HomeStyles intervention enables and motivates parents to shape the weight-related aspects of their home environments and lifestyle behavioral practices (diet, exercise, and sleep) to be more supportive of their preschool children's optimal health and weight...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28440782/systematization-of-clinical-trials-related-to-treatment-of-metabolic-syndrome-1980-2015
#13
Santiago Cardona Velásquez, Laura Guzmán Vivares, Jaiberth Antonio Cardona-Arias
INTRODUCTION: Despite the clinical, epidemiological, and economic significance of metabolic syndrome, the profile of clinical trials on this disease is unknown. OBJECTIVE: To characterize the clinical trials related to treatment of metabolic syndrome during the 1980-2015 period. METHODS: Systematic review of the literature using an ex ante search protocol which followed the phases of the guide Preferred Reporting Items for Systematic Reviews and Meta-Analyses in four multidisciplinary databases with seven search strategies...
February 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28440752/assessment-study-of-the-nutritional-status-eating-habits-and-physical-activity-of-the-schooled-population-of-centelles-hostalets-de-baleny%C3%A3-and-sant-mart%C3%A3-de-centelles-alin-2014-study
#14
Queralt Aguilà, Maria Àngels Ramón, Susana Matesanz, Ramon Vilatimó, Irene Del Moral, Carles Brotons, Àngels Ulied
BACKGROUND AND OBJECTIVE: Malnourishment can be caused by either a lack of food or an excess of low-nutrient foods. Due to several factors, this predisposes children to academic failure. The objective of this study is to estimate the prevalence of school children with eating problems, study their nutrition level, food quality in the diet, and level of physical activity. MATERIAL AND METHODS: The study involved the school children between 3 months and 16.5 years of age in the municipalities of Centelles, Hostalets de Balenyà and Sant Martí de Centelles...
March 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28440197/hyperprolactinemia-induced-by-antipsychotics-from-diagnosis-to-treatment-approach
#15
Walter Milano, Chiara Colletti, Anna Capasso
Schizophrenia is one of the most severe psychiatric diseases with a significant impact on the psychosocial functioning of the patients. People with schizophrenia are at risk to die prematurely because of their illness with their poor lifestyle contributing to the excess morbidity and higher mortality rate. In particular, lifestyle (e.g. poor diet, low rates of physical activity and increased likelihood to smoke cigarettes) predisposes them to poor physical health and comorbid medical diseases. In addition, the treatment of schizophrenia usually involves the long-term administration of antipsychotic drugs and some of these medications are implicated in the increased risk of metabolic and cardiovascular effects...
April 23, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28438715/impact-of-physical-exercise-on-visceral-adipose-tissue-fatty-acid-profile-and-inflammation-in-response-to-a-high-fat-diet-regimen
#16
Sílvia Rocha-Rodrigues, Amaia Rodríguez, Inês O Gonçalves, Ana Moreira, Elisabete Maciel, Sónia Santos, Maria R Domingues, Gema Frühbeck, António Ascensão, José Magalhães
PURPOSE: Studies associate specific fatty-acids (FA) with the pathophysiology of inflammation. We aimed to analyze the impact of exercise on adipose tissue FA profile in response to a high-fat diet (HFD) and to ascertain whether these exercise-induced changes in specific FA have repercussions on obesity-related inflammation. METHODS: Sprague-Dawley rats were assigned into sedentary, voluntary physical-activity (VPA) and endurance training (ET) groups fed a standard (S, 35kcal% fat) or high-fat (71kcal% fat) diets...
April 21, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28438036/enhancing-periconceptional-health-by-targeting-postpartum-mothers-at-rural-wic-clinics
#17
Jini E Puma, Darcy Thompson, Katherine Baer, Matthew A Haemer, Kevin Gilbert, Michael Hambidge, Nancy F Krebs
The overall goal of this pilot quality improvement (QI) intervention was to (1) assess the feasibility of making a WIC (Women, Infants, and Children) systems-level change that added measurement of maternal weight and discussion of maternal health habits into each postpartum maternal and offspring visit in rural clinics in Colorado and (2) assess the impacts of the intervention on maternal diet, physical activity, and weight status. A mixed-method evaluation approach was used involving the collection of quantitative data (HeartSmartMoms usage reports, manual WIC chart reviews [to calculate screening rates], pre-/postsurveys, and weight status [body mass index]) and qualitative data (focus groups and project team meeting minutes)...
April 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28437380/lifestyle-and-neurocognition-in-older-adults-with-cardiovascular-risk-factors-and-cognitive-impairment
#18
James A Blumenthal, Patrick J Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N Browndyke, Pao-Hwa Lin, William Kraus, P Murali Doraiswamy, James Burke, Andrew Sherwood
OBJECTIVE: To determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, without dementia (CIND). METHODS: One hundred sixty adults (Mean = 65.4±6.8 years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and DASH diets were obtained to assess direct effects with neurocognition...
April 21, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28436241/academic-performance-and-lifestyle-behaviors-in-australian-school-children-a-cluster-analysis
#19
Dorothea Dumuid, Timothy Olds, Josep-Antoni Martín-Fernández, Lucy K Lewis, Leah Cassidy, Carol Maher
Poor academic performance has been linked with particular lifestyle behaviors, such as unhealthy diet, short sleep duration, high screen time, and low physical activity. However, little is known about how lifestyle behavior patterns (or combinations of behaviors) contribute to children's academic performance. We aimed to compare academic performance across clusters of children with common lifestyle behavior patterns. We clustered participants (Australian children aged 9-11 years, n = 284) into four mutually exclusive groups of distinct lifestyle behavior patterns, using the following lifestyle behaviors as cluster inputs: light, moderate, and vigorous physical activity; sedentary behavior and sleep, derived from 24-hour accelerometry; self-reported screen time and diet...
April 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28436099/review-of-nutrition-guidelines-relevant-for-adolescents-in-low-and-middle-income-countries
#20
REVIEW
Zohra S Lassi, Tarab Mansoor, Rehana A Salam, Shereen Z Bhutta, Jai K Das, Zulfiqar A Bhutta
The economic and social well-being of any country will one day depend on its current adolescent population. To provide a good foundation for healthy adolescent development, healthy diet, along with physical activity and adequate nutrients, is necessary. Therefore, addressing the nutrition needs of adolescents could be an important step toward breaking the vicious cycle of intergenerational malnutrition, chronic diseases, and poverty. These problems could be addressed with timely recognition and appropriately delivered interventions...
April 2017: Annals of the New York Academy of Sciences
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