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Matthew R Pincus

Alexander P Nesmith, Matthew A Wagner, Francesco S Pasqualini, Blakely B O'Connor, Mark J Pincus, Paul R August, Kevin Kit Parker
Tongue weakness, like all weakness in Duchenne muscular dystrophy (DMD), occurs as a result of contraction-induced muscle damage and deficient muscular repair. Although membrane fragility is known to potentiate injury in DMD, whether muscle stem cells are implicated in deficient muscular repair remains unclear. We hypothesized that DMD myoblasts are less sensitive to cues in the extracellular matrix designed to potentiate structure-function relationships of healthy muscle. To test this hypothesis, we drew inspiration from the tongue and engineered contractile human muscle tissues on thin films...
October 10, 2016: Journal of Cell Biology
Sergei Guma, Remegio Maglantay, Ryan Lau, Rosemary Wieczorek, Jonathan Melamed, Fang-Ming Deng, Ming Zhou, Danil Makarov, Peng Lee, Matthew R Pincus, Zhi-Heng Pei
BACKGROUND: The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Here, we report a case of urothelial carcinoma with squamous differentiation associated with HPV-6/HPV-11. CASE PRESENTATION: This is a case of a 70 year old man who presented with nocturia and pressure during urination...
2016: American Journal of Clinical and Experimental Urology
Jeremy S Peterman, Matthew M Carper, R Meredith Elkins, Jonathan S Comer, Donna B Pincus, Philip C Kendall
The present study examined (a) whether sleep related problems (SRPs) improved following cognitive-behavioral therapy (CBT) for youth with anxiety disorders, (b) whether variables that may link anxiety and SRPs (e.g., pre-sleep arousal, family accommodation, sleep hygiene) changed during treatment, and (c) whether such changes predicted SRPs at posttreatment. Youth were diagnosed with anxiety at pretreatment and received weekly CBT that targeted their principal anxiety diagnosis at one of two specialty clinics (N=69 completers, Mage=10...
January 2016: Journal of Anxiety Disorders
Ehsan Sarafraz-Yazdi, Constantine Gorelick, Allison R Wagreich, Ghadir Salame, Mallorie Angert, Charles H Gartman, Vinita Gupta, Wilbur B Bowne, Yi-Chun Lee, Ovadia Abulafia, Matthew R Pincus, Josef Michl
OBJECTIVE: Despite an 80% response rate to chemotherapy, epithelial ovarian cancer has the highest case fatality rate of all gynecologic malignancies. Several studies have shown the efficiency of anticancer peptides PNC-27 and PNC-28 in killing a variety of cancer cells selectively in vitro and in vivo. The purpose of this study was to evaluate the efficacy of PNC-27 against human primary epithelial ovarian cancer. METHODS: We established primary cultures of freshly isolated epithelial ovarian cancer cells from patients with newly diagnosed ovarian cystadenocarcinomas...
2015: Annals of Clinical and Laboratory Science
Aaron Harper, Chuanyong Lu, Yi Sun, Rafael Garcia, Anton Rets, Herol Alexis, Heba Saad, Ikram Eid, Loretta Harris, Barbara Marshall, Edlira Tafani, Matthew R Pincus
GOALS: The goal of this work was to determine if immediate versus postponed centrifugation of samples affects the levels of serum potassium. METHODS: Twenty participants donated normal venous blood that was collected in four serum separator tubes per donor, each of which was analyzed at 0, 1, 2, or 4 hr on the Siemens Advia 1800 autoanalyzer. RESULTS: Coefficients of variation (CVs) for potassium levels ranged from 0% to 7.6% with a mean of 3 ± 2%...
May 2016: Journal of Clinical Laboratory Analysis
Christian Hamilton-Craig, Allison Fifoot, Mark Hansen, Matthew Pincus, Jonathan Chan, Darren L Walters, Kelley R Branch
BACKGROUND: Coronary CT angiography (CCTA) has high sensitivity, with 3 recent randomized trials favorably comparing CCTA to standard-of-care. Comparison to exercise stress ECG (ExECG), the most available and least expensive standard-of-care worldwide, has not been systematically tested. METHODS: CT-COMPARE was a randomized, single-center trial of low-intermediate risk chest pain subjects undergoing CCTA or ExECG after the first negative troponin. From March 2010 to April 2011, 562 patients randomized to either dual-source CCTA (n=322) or ExECG (n=240)...
December 20, 2014: International Journal of Cardiology
Matthew R Pincus, Zhiheng Pei
No abstract text is available yet for this article.
December 2014: Clinics in Laboratory Medicine
Matthew R Pincus, Jannie Woo, Regina Monaco, Jack Lubowsky, Matthew J Avitable, Robert P Carty
Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. We have found 5,077 solvated conformations with conformational energies that were within 5 kcal/mole of that of the global minimum. These minima were found to occur in 802 distinct conformational classes of which 25 represented 70 % of the Boltzmann energy-weighted structures...
December 2014: Protein Journal
Katlin Davitt, Blake D Babcock, Maly Fenelus, Chi Kong Poon, Abhishek Sarkar, Vincent Trivigno, Paul A Zolkind, Sheena M Matthew, Natalia Grin'kina, Zulfiya Orynbayeva, Mohammad F Shaikh, Victor Adler, Josef Michl, Ehsan Sarafraz-Yazdi, Matthew R Pincus, Wilbur B Bowne
GOALS: We have developed the anti-cancer peptide, PNC-27, which is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells. We now extend our study to non-solid tissue tumor cells, in this case, a primitive, possible stem cell human leukemia cell line (K562) that is also p53-homozygously deleted...
2014: Annals of Clinical and Laboratory Science
Martin Ligr, Xinyu Wu, Garrett Daniels, David Zhang, Huamin Wang, Cristina Hajdu, Jinhua Wang, Ruimin Pan, Zhiheng Pei, Lanjing Zhang, Marcovalerio Melis, Matthew R Pincus, John K Saunders, Peng Lee, Ruliang Xu
Transcriptional intermediary factor 1 gamma (Tif1γ) (Ectodermin/PTC7/RFG7/TRIM33) is a transcriptional cofactor with an important role in the regulation of the TGFβ pathway. It has been suggested that it competes with Smad2/Smad3 for binding to Smad4, or alternatively that it may target Smad4 for degradation, although its role in carcinogenesis is unclear. In this study, we showed that Tif1γ interacts with Smad1/Smad4 complex in vivo, using both yeast two-hybrid and coimmunoprecipitation assays. We demonstrated that Tif1γ inhibits transcriptional activity of the Smad1/Smad4 complex through its PHD domain or bromo-domainin pancreatic cells by luciferase assay...
2014: American Journal of Cancer Research
Jia Qin, Huiying Wang, Anton Rets, Saul Harari, Herol Alexis, Ikram Eid, Matthew R Pincus
BACKGROUND: Serum creatinine values of patients tend to change as a result of the use of different blanks used for creatinine determinations on the Advia 1650. After upgrading the analyzer to the Advia 1800, creatinine values tended to be more reproducible. As part of a quality assurance investigation to test the reproducibilities of creatinine values, we determined serial creatinine values in the sera of 13 patients whose initial values were either in the reference range or elevated (range 0...
November 2013: Journal of Clinical Laboratory Analysis
Geling Li, Michael Cabanero, Zhenglong Wang, Huiying Wang, Tao Huang, Herol Alexis, Ikram Eid, Gilad Muth, Matthew R Pincus
Because of the metabolism of serum glucose in collection tubes containing blood samples, serum glucose levels may be found to decrease over time. Several types of collection tubes have been designed to, at least partially, block glucose metabolism by red blood cells in blood collection tubes that may not be analyzed immediately after blood collection. These include red-top collection tubes with serum separator, grey-top tubes with a fluoride glycolysis inhibitor, and heparin-containing green-top tubes which prevent clot formation...
2013: Annals of Clinical and Laboratory Science
Matthew R Pincus, Robert P Carty, Michael Harding, William Epstein
Using the chain build-up procedure based on the program ECEPP, we have computed the lowest energy structures for two terminally blocked subsequences from the antigenic circumsporozoite protein of Plasmodium berghei, that is known to cause malaria in animals. The full antigenic sequence is an octapeptide proline-rich tandem repeat, (Pro-Pro-Pro-Pro-Asn-Pro-Asn-Asp)(2). We computed the structures for the first octapeptide plus one Pro from the second octapeptide, terminally blocked CH(3)CO-Pro-Pro-Pro-Pro-Asn-Pro-Asn-Asp-Pro-NHCH(3) as well as the first octpeptide with an additional three Pro residues from the adjoining unit, i...
January 2013: Protein Journal
Anton V Rets, Issa Eid, Larry Lutwick, Matthew R Pincus
Human diseases caused by Haemophilus paraphrophilus (H.paraphrophilus) are unusual. The following case report describes a 67-year-old man who presented with pain and swelling of the right side of the face. Fine needle aspiration suggested a parotid gland abscess. Microbiological studies identified H.paraphrophilus. This is the first time a parotid abscess has been found to be caused by this organism.
2012: Annals of Clinical and Laboratory Science
Rafael Garcia, Geling Li, Zhenglong Wang, Michael Cabanero, Matthew R Pincus
BACKGROUND: It is sometimes necessary for the laboratory to re-test samples for critical serum electrolyte levels. It is important to assure reproducibility of results when testing is performed on stored, refrigerated samples. We have tested the reproducibility of results for the critical electrolytes, Na, K, Cl and Ca, from ten randomly selected patients'sera over our maximum storage period of nine (9) days on the Siemens Advia 1800 analyzer. The ranges for each electrolyte were 131-150 meq/L (Na), 3...
September 2012: Journal of Clinical Laboratory Analysis
Matthew R Pincus, Maly Fenelus, Ehsan Sarafraz-Yazdi, Victor Adler, Wilbur Bowne, Josef Michl
We have employed computer-based molecular modeling approaches to design peptides from the ras-p21 and p53 proteins that either induce tumor cell reversion to the untransformed phenotype or induce tumor cell necrosis without affecting normal cells. For rasp21, we have computed and superimposed the average low energy structures for the wild-type protein and oncogenic forms of this protein and found that specific domains change conformation in the oncogenic proteins. We have synthesized peptides corresponding to these and found that ras peptides, 35-47 (PNC-7) and 96-110 (PNC-2), block oncogenic ras-p21-induced oocyte maturation but have no effect on insulin-induced oocyte maturation that requires activation of endogenous wild-type ras-p21...
2011: Current Pharmaceutical Design
Florencia Pereyra, Xiaoming Jia, Paul J McLaren, Amalio Telenti, Paul I W de Bakker, Bruce D Walker, Stephan Ripke, Chanson J Brumme, Sara L Pulit, Mary Carrington, Carl M Kadie, Jonathan M Carlson, David Heckerman, Robert R Graham, Robert M Plenge, Steven G Deeks, Lauren Gianniny, Gabriel Crawford, Jordan Sullivan, Elena Gonzalez, Leela Davies, Amy Camargo, Jamie M Moore, Nicole Beattie, Supriya Gupta, Andrew Crenshaw, Noël P Burtt, Candace Guiducci, Namrata Gupta, Xiaojiang Gao, Ying Qi, Yuko Yuki, Alicja Piechocka-Trocha, Emily Cutrell, Rachel Rosenberg, Kristin L Moss, Paul Lemay, Jessica O'Leary, Todd Schaefer, Pranshu Verma, Ildiko Toth, Brian Block, Brett Baker, Alissa Rothchild, Jeffrey Lian, Jacqueline Proudfoot, Donna Marie L Alvino, Seanna Vine, Marylyn M Addo, Todd M Allen, Marcus Altfeld, Matthew R Henn, Sylvie Le Gall, Hendrik Streeck, David W Haas, Daniel R Kuritzkes, Gregory K Robbins, Robert W Shafer, Roy M Gulick, Cecilia M Shikuma, Richard Haubrich, Sharon Riddler, Paul E Sax, Eric S Daar, Heather J Ribaudo, Brian Agan, Shanu Agarwal, Richard L Ahern, Brady L Allen, Sherly Altidor, Eric L Altschuler, Sujata Ambardar, Kathryn Anastos, Ben Anderson, Val Anderson, Ushan Andrady, Diana Antoniskis, David Bangsberg, Daniel Barbaro, William Barrie, J Bartczak, Simon Barton, Patricia Basden, Nesli Basgoz, Suzane Bazner, Nicholaos C Bellos, Anne M Benson, Judith Berger, Nicole F Bernard, Annette M Bernard, Christopher Birch, Stanley J Bodner, Robert K Bolan, Emilie T Boudreaux, Meg Bradley, James F Braun, Jon E Brndjar, Stephen J Brown, Katherine Brown, Sheldon T Brown, Jedidiah Burack, Larry M Bush, Virginia Cafaro, Omobolaji Campbell, John Campbell, Robert H Carlson, J Kevin Carmichael, Kathleen K Casey, Chris Cavacuiti, Gregory Celestin, Steven T Chambers, Nancy Chez, Lisa M Chirch, Paul J Cimoch, Daniel Cohen, Lillian E Cohn, Brian Conway, David A Cooper, Brian Cornelson, David T Cox, Michael V Cristofano, George Cuchural, Julie L Czartoski, Joseph M Dahman, Jennifer S Daly, Benjamin T Davis, Kristine Davis, Sheila M Davod, Edwin DeJesus, Craig A Dietz, Eleanor Dunham, Michael E Dunn, Todd B Ellerin, Joseph J Eron, John J W Fangman, Claire E Farel, Helen Ferlazzo, Sarah Fidler, Anita Fleenor-Ford, Renee Frankel, Kenneth A Freedberg, Neel K French, Jonathan D Fuchs, Jon D Fuller, Jonna Gaberman, Joel E Gallant, Rajesh T Gandhi, Efrain Garcia, Donald Garmon, Joseph C Gathe, Cyril R Gaultier, Wondwoosen Gebre, Frank D Gilman, Ian Gilson, Paul A Goepfert, Michael S Gottlieb, Claudia Goulston, Richard K Groger, T Douglas Gurley, Stuart Haber, Robin Hardwicke, W David Hardy, P Richard Harrigan, Trevor N Hawkins, Sonya Heath, Frederick M Hecht, W Keith Henry, Melissa Hladek, Robert P Hoffman, James M Horton, Ricky K Hsu, Gregory D Huhn, Peter Hunt, Mark J Hupert, Mark L Illeman, Hans Jaeger, Robert M Jellinger, Mina John, Jennifer A Johnson, Kristin L Johnson, Heather Johnson, Kay Johnson, Jennifer Joly, Wilbert C Jordan, Carol A Kauffman, Homayoon Khanlou, Robert K Killian, Arthur Y Kim, David D Kim, Clifford A Kinder, Jeffrey T Kirchner, Laura Kogelman, Erna Milunka Kojic, P Todd Korthuis, Wayne Kurisu, Douglas S Kwon, Melissa LaMar, Harry Lampiris, Massimiliano Lanzafame, Michael M Lederman, David M Lee, Jean M L Lee, Marah J Lee, Edward T Y Lee, Janice Lemoine, Jay A Levy, Josep M Llibre, Michael A Liguori, Susan J Little, Anne Y Liu, Alvaro J Lopez, Mono R Loutfy, Dawn Loy, Debbie Y Mohammed, Alan Man, Michael K Mansour, Vincent C Marconi, Martin Markowitz, Rui Marques, Jeffrey N Martin, Harold L Martin, Kenneth Hugh Mayer, M Juliana McElrath, Theresa A McGhee, Barbara H McGovern, Katherine McGowan, Dawn McIntyre, Gavin X Mcleod, Prema Menezes, Greg Mesa, Craig E Metroka, Dirk Meyer-Olson, Andy O Miller, Kate Montgomery, Karam C Mounzer, Ellen H Nagami, Iris Nagin, Ronald G Nahass, Margret O Nelson, Craig Nielsen, David L Norene, David H O'Connor, Bisola O Ojikutu, Jason Okulicz, Olakunle O Oladehin, Edward C Oldfield, Susan A Olender, Mario Ostrowski, William F Owen, Eunice Pae, Jeffrey Parsonnet, Andrew M Pavlatos, Aaron M Perlmutter, Michael N Pierce, Jonathan M Pincus, Leandro Pisani, Lawrence Jay Price, Laurie Proia, Richard C Prokesch, Heather Calderon Pujet, Moti Ramgopal, Almas Rathod, Michael Rausch, J Ravishankar, Frank S Rhame, Constance Shamuyarira Richards, Douglas D Richman, Berta Rodes, Milagros Rodriguez, Richard C Rose, Eric S Rosenberg, Daniel Rosenthal, Polly E Ross, David S Rubin, Elease Rumbaugh, Luis Saenz, Michelle R Salvaggio, William C Sanchez, Veeraf M Sanjana, Steven Santiago, Wolfgang Schmidt, Hanneke Schuitemaker, Philip M Sestak, Peter Shalit, William Shay, Vivian N Shirvani, Vanessa I Silebi, James M Sizemore, Paul R Skolnik, Marcia Sokol-Anderson, James M Sosman, Paul Stabile, Jack T Stapleton, Sheree Starrett, Francine Stein, Hans-Jurgen Stellbrink, F Lisa Sterman, Valerie E Stone, David R Stone, Giuseppe Tambussi, Randy A Taplitz, Ellen M Tedaldi, Amalio Telenti, William Theisen, Richard Torres, Lorraine Tosiello, Cecile Tremblay, Marc A Tribble, Phuong D Trinh, Alice Tsao, Peggy Ueda, Anthony Vaccaro, Emilia Valadas, Thanes J Vanig, Isabel Vecino, Vilma M Vega, Wenoah Veikley, Barbara H Wade, Charles Walworth, Chingchai Wanidworanun, Douglas J Ward, Daniel A Warner, Robert D Weber, Duncan Webster, Steve Weis, David A Wheeler, David J White, Ed Wilkins, Alan Winston, Clifford G Wlodaver, Angelique van't Wout, David P Wright, Otto O Yang, David L Yurdin, Brandon W Zabukovic, Kimon C Zachary, Beth Zeeman, Meng Zhao
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere...
December 10, 2010: Science
Kelley A Sookraj, Wilbur B Bowne, Victor Adler, Ehsan Sarafraz-Yazdi, Josef Michl, Matthew R Pincus
PURPOSE: PNC-27, a peptide that contains an HDM-2-binding domain from p53 attached to a membrane-penetrating peptide on its carboxyl terminal end, is cytotoxic to cancer, but not normal, cells. It forms transmembrane pores in the cancer cell membrane. Our purpose is to determine if the whole peptide or critical fragments induce pore formation in cancer cells. METHODS: We have prepared PNC-27 with a green fluorescent label on its amino terminus and a red fluorescent label on its carboxyl terminus and treated MCF-7 breast cancer cells and untransformed MCF-10-2A breast epithelial cells with this double-labeled peptide to determine if combined yellow fluorescence occurs in the membrane of the cancer cells during cancer cell killing...
July 2010: Cancer Chemotherapy and Pharmacology
Ehsan Sarafraz-Yazdi, Wilbur B Bowne, Victor Adler, Kelley A Sookraj, Vernon Wu, Vadim Shteyler, Hunaiz Patel, William Oxbury, Paul Brandt-Rauf, Michael E Zenilman, Josef Michl, Matthew R Pincus
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is directly superimposable on the structure for the same residues bound to HDM-2, suggesting that the peptide may target HDM-2 in the membranes of cancer cells. We now find significant levels of HDM-2 in the membranes of a variety of cancer cells but not in the membranes of several untransformed cell lines...
February 2, 2010: Proceedings of the National Academy of Sciences of the United States of America
Jie Ouyang, Miguel Guzman, Fidelina Desoto-Lapaix, Matthew R Pincus, Rosemary Wieczorek
Detection of early acute myocardial ischemia/infarction prior to neutrophilic infiltration in autopsy myocardium poses a diagnostic dilemma to the surgical pathologist. Morphological changes can be subtle or not identified at all on the hematoxylin and eosin stain. To evaluate the Masson's trichrome stain and immunohistochemical stains, desmin and myoglobin, in detecting acute myocardial ischemia/infarction in autopsy myocardium. We reviewed the autopsy files of the New York Harbor Healthcare System and retrieved 25 cases of early acute myocardial infarction...
2009: International Journal of Clinical and Experimental Pathology
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