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Alejandro A Gru, Jinah Kim, Melissa Pulitzer, Joan Guitart, Maxime Battistella, Gary S Wood, Lorenzo Cerroni, Werner Kempf, Rein Willemze, Joya Pawade, Christiane Querfeld, Andras Schaffer, Laura Pincus, Michael Tetzlaff, Madeleine Duvic, Julia Scarisbrick, Pierluigi Porcu, Aaron R Mangold, David J Dicaudio, Michi Shinohara, Eric K Hong, Bethany Horton, Youn H Kim
This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas...
March 14, 2018: American Journal of Surgical Pathology
Leanne K Knobloch, Lynne M Knobloch-Fedders, Jeremy B Yorgason
This study draws on the emotional cycle of deployment model (Pincus, House, Christenson, & Adler, 2001) to consider how the valence of communication between military personnel and at-home partners during deployment predicts their generalized anxiety upon reunion. Online survey data were collected from 555 military couples (N = 1,110 individuals) once per month for 8 consecutive months beginning at homecoming. Dyadic growth curve modeling results indicated that people's anxiety declined across the transition...
February 2018: Journal of Family Psychology: JFP
Can Kayatekin, Audra Amasino, Giorgio Gaglia, Jason Flannick, Julia M Bonner, Saranna Fanning, Priyanka Narayan, M Inmaculada Barrasa, David Pincus, Dirk Landgraf, Justin Nelson, William R Hesse, Michael Costanzo, Chad L Myers, Charles Boone, Jose C Florez, Susan Lindquist
Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type 2 diabetes (T2D) are thought to contribute to β cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a yeast model of IAPP toxicity. Ste24, an evolutionarily conserved protease that was recently reported to degrade peptides stuck within the translocon between the cytoplasm and the endoplasmic reticulum, was the strongest suppressor of IAPP toxicity. By testing variants of the human homolog, ZMPSTE24, with varying activity levels, the rescue of IAPP toxicity proved to be directly proportional to the declogging efficiency...
March 5, 2018: Cell
Evgeniy R Galimov, Rosina E Pryor, Sarah E Poole, Alexandre Benedetto, Zachary Pincus, David Gems
Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis...
March 6, 2018: Cell Reports
Nicola Holt, Gemma Mansell, Jonathan C Hill, Tamar Pincus
OBJECTIVES: Reassurance is an essential part of treatment for low back pain (LBP), but evidence on effective methods to deliver reassurance remains scarce. The interaction between consultation-based reassurance and patients' psychological risk is unknown. Our objective was to investigate the relationship between consultation-based reassurance and clinical outcomes at follow-up, in people with and without psychological risk. METHODS: We tested the associations between specific reassurance components (data gathering, relationship building, generic reassurance, and cognitive reassurance), patients' psychological risk (the presence of depression, anxiety, catastrophizing, or fear-avoidance), and postconsultation outcomes including, satisfaction and enablement, disability, pain, and mood at 3-month follow-up...
April 2018: Clinical Journal of Pain
Parashar Pravin Ramanuj, Rachel Talley, Joshua Breslau, Scarlett Sijia Wang, Harold Alan Pincus
People with co-occurring behavioral and physical conditions receive poorer care through traditional health care services. One solution has been to integrate behavioral and physical care services. This study assesses efforts to integrate behavioral health and primary care services in New York. Semi-structured interviews were conducted with 52 professionals in either group or individual settings. We aimed to identify factors which facilitate or hinder integration for people with serious mental illness and how these factors inter-relate...
February 27, 2018: Community Mental Health Journal
Ruxin Li, Di Xiao, Jing Yang, Suju Sun, Samuel Kaplan, Zhirong Li, Yanan Niu, Cuixin Qiang, Yu Zhai, Xiaoming Wang, Xingzhen Zhao, Baoxin Zhao, Martin Welker, David H Pincus, Dazhi Jin, Mini Kamboj, Guanghui Zheng, Guojun Zhang, Jianzhong Zhang, Yi-Wei Tang, Jianhong Zhao
Clostridium difficile multilocus sequence type 37 (ST37), which mainly corresponds to ribotype 017, has been a dominant genotype circulating in China. In this study, we report the use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to analyze and characterize 204 C. difficile clinical isolates including 49 ST37 and 155 non-ST37 isolates collected in China and other countries. Distribution of two major protein peaks ( m/z 3242 and 3286) was significantly different between ST37 and non-ST37 prototype strains and clinical isolates...
February 21, 2018: Journal of Clinical Microbiology
Matthew L Goldman, Brigitta Spaeth-Rublee, Harold Alan Pincus
Extensive evidence documents that people with severe mental illness have higher rates of morbidity and mortality compared with the general population and receive lower-quality and higher-cost health care. These trends, at least in part, stem from discrimination, exclusion, widespread stigma, and criminalization of individuals with mental illness. As such, severe mental illness should receive formal, national recognition as a disparities category. Such a designation would have multiple important implications in health policy, services and quality research, and advocacy...
February 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Tamar Pincus, Melanie Noel, Abbie Jordan, Danijela Serbic
No abstract text is available yet for this article.
February 6, 2018: Pain
Eric J Solís, Jai P Pandey, Xu Zheng, Dexter X Jin, Piyush B Gupta, Edoardo M Airoldi, David Pincus, Vladimir Denic
No abstract text is available yet for this article.
February 1, 2018: Molecular Cell
Joanna Krakowiak, Xu Zheng, Nikit Patel, Zoë A Feder, Jayamani Anandhakumar, Kendra Valerius, David S Gross, Ahmad S Khalil, David Pincus
Models for regulation of the eukaryotic heat shock response typically invoke a negative feedback loop consisting of the transcriptional activator Hsf1 and a molecular chaperone. Previously we identified Hsp70 as the chaperone responsible for Hsf1 repression and constructed a mathematical model that recapitulated the yeast heat shock response (Zheng et al., 2016). The model was based on two assumptions: dissociation of Hsp70 activates Hsf1, and transcriptional induction of Hsp70 deactivates Hsf1. Here we validate these assumptions...
February 2, 2018: ELife
J Wesley Scala, Kenneth N Levy, Benjamin N Johnson, Yogev Kivity, William D Ellison, Aaron L Pincus, Stephen J Wilson, Michelle G Newman
Deficits in identity as well as negative affect have been shown to predict self-injurious and suicidal behaviors in individuals with borderline personality disorder (BPD). However, less is known about the interactive effects of these two predictors. We examined the moderating effect of a particular component of identity, self-concept, on the relationship between negative affect and self-injurious urges utilizing ecological momentary assessments. Outpatients diagnosed with either BPD (n = 36) or any anxiety disorder but no BPD (n = 18) completed surveys throughout the day over a 21-day period...
January 2018: Journal of Personality Disorders
Amy M Kilbourne, Kathryn Beck, Brigitta Spaeth-Rublee, Parashar Ramanuj, Robert W O'Brien, Naomi Tomoyasu, Harold Alan Pincus
Mental disorders are common worldwide, yet the quality of care for these disorders has not increased to the same extent as that for physical conditions. In this paper, we present a framework for promoting quality measurement as a tool for improving quality of mental health care. We identify key barriers to this effort, including lack of standardized information technology-based data sources, limited scientific evidence for mental health quality measures, lack of provider training and support, and cultural barriers to integrating mental health care within general health environments...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Leah Feinberg, Caroline Kerns, Donna B Pincus, Jonathan S Comer
Studies point to parental experiential avoidance (EA) as a potential correlate of maladaptive parenting behaviors associated with child anxiety. However, research has not examined the relationship between EA and parental accommodation of child anxiety, nor the extent to which parental negative beliefs about child anxiety help explain such a relationship. In a sample of mothers (N = 45) of anxious and non-anxious children, the present study investigated the potential link between maternal EA and accommodation of child anxiety and whether this link may be indirectly accounted for via maternal negative beliefs about child anxiety...
January 19, 2018: Child Psychiatry and Human Development
Melissa R Arbuckle, Sean X Luo, Harold Alan Pincus, Joshua A Gordon, Joyce Y Chung, Mark Chavez, Maria A Oquendo
OBJECTIVE: The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. METHODS: Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology)...
January 4, 2018: Academic Psychiatry
Ellen Hartmann, Kirsten Benum
This case study used test data from a patient with Dissociative Identity Disorder (DID; American Psychiatric Association, 2013 ) to illustrate how two main personality states of the patient ("Ann" and "Ben") seemed to function. The Rorschach Performance Assessment System (R-PAS; Meyer, Viglione, Mihura, Erard, & Erdberg, 2011 ) and the Inventory of Interpersonal Problems-Circumplex (IIP-64; Horowitz, Alden, Wiggins, & Pincus, 2000 ), administered to Ann and Ben in separate settings, exposed two diverse R-PAS and IIP-64 profiles...
December 13, 2017: Journal of Personality Assessment
Christopher J Hopwood, Roman Kotov, Robert F Krueger, David Watson, Thomas A Widiger, Robert R Althoff, Emily B Ansell, Bo Bach, R Michael Bagby, Mark A Blais, Marina A Bornovalova, Michael Chmielewski, David C Cicero, Christopher Conway, Barbara De Clercq, Filip De Fruyt, Anna R Docherty, Nicholas R Eaton, John F Edens, Miriam K Forbes, Kelsie T Forbush, Michael P Hengartner, Masha Y Ivanova, Daniel Leising, W John Livesley, Mark R Lukowitsky, Donald R Lynam, Kristian E Markon, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, J Hans Ormel, Christopher J Patrick, Aaron L Pincus, Camilo Ruggero, Douglas B Samuel, Martin Sellbom, Tim Slade, Jennifer L Tackett, Katherine M Thomas, Timothy J Trull, David D Vachon, Irwin D Waldman, Monika A Waszczuk, Mark H Waugh, Aidan G C Wright, Mathew M Yalch, David H Zald, Johannes Zimmermann
No abstract text is available yet for this article.
February 2018: Personality and Mental Health
Carlos El-Haddad, Isabel Castrejon, Kathryn A Gibson, Yusuf Yazici, Martin J Bergman, Theodore Pincus
Objective: To compare patients with a primary diagnosis of osteoarthritis (OA) versus rheumatoid arthritis (RA) for scores on a patient self-report MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data 3), and for physician global assessment (DOCGL). Methods: All patients with all diagnoses complete an MDHAQ/RAPID3 at all routine rheumatology visits in the waiting area before seeing a rheumatologist at four sites, one in Australia and three in the USA...
2017: RMD Open
Bridget Poznanski, Danielle Cornacchio, Stefany Coxe, Donna B Pincus, Dana L McMakin, Jonathan S Comer
Although recent studies have linked pediatric anxiety to irritability, research has yet to examine the mechanisms through which youth anxiety may be associated with irritability. Importantly, sleep related problems (SRPs) have been associated with both child anxiety and irritability, but research has not considered whether the link between youth anxiety and irritability may be accounted for by SRPs. The present study investigated whether SRPs mediated the relationship between anxiety severity and irritability in a large sample of treatment-seeking anxious youth (N = 435; ages 7-19 years, M = 12...
December 8, 2017: Child Psychiatry and Human Development
George Braitberg, Marie Gerdtz, Susan Harding, Steven Pincus, Michelle Thompson, Jonathan Knott
OBJECTIVE: We aimed to assess the impact of a new model of care for patients presenting to the ED with acute behavioural disturbance. METHODS: This pre-/post-intervention study involved creating a dedicated, highly resourced six bed unit, the behavioural assessment unit (BAU). Co-located with the ED at the Royal Melbourne Hospital, the unit was designed to fast-track the admission of patients affected by intoxication, mental illness or psychosocial crisis and provide front-loaded interventions...
December 8, 2017: Emergency Medicine Australasia: EMA
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