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https://www.readbyqxmd.com/read/28534519/two-forms-of-death-in-ageing-caenorhabditis-elegans
#1
Yuan Zhao, Ann F Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David McBay, William B Zhang, Linda Partridge, Zachary Pincus, David Gems
Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call 'P deaths'), and later deaths with an atrophied pharynx (termed 'p deaths'). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28513344/pathological-narcissism-and-nonsuicidal-self-injury
#2
Sindes Dawood, Hans S Schroder, M Brent Donnellan, Aaron L Pincus
Few studies have examined associations between pathological narcissism and self-harm, but those that do indicate that narcissistic vulnerability (not narcissistic grandiosity) relates to self-harm. The current study extends this literature by investigating how facets of pathological narcissism assessed by the Pathological Narcissism Inventory relate to specific nonsuicidal self-injury (NSSI) behaviors assessed by the Inventory of Statements About Self-Injury using statistical models appropriate for non-normally distributed count data...
May 17, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28512998/implementation-of-treat-to-target-in-rheumatoid-arthritis-through-a-learning-collaborative-results-of-the-traction-randomized-controlled-trial
#3
Daniel H Solomon, Elena Losina, Bing Lu, Agnes Zak, Cassandra Corrigan, Sara B Lee, Jenifer Agosti, Asaf Bitton, Leslie R Harrold, Ted Pincus, Helga Radner, Zhi Yu, Josef S Smolen, Liana Fraenkel, Jeffrey N Katz
BACKGROUND: Treat to target (TTT) is an accepted paradigm for management of rheumatoid arthritis (RA), but some evidence suggests poor adherence. We tested the effects of a group-based multi-site improvement Learning Collaborative (LC) on adherence to TTT. METHODS: We conducted a cluster-randomized quality improvement trial with wait-list control across 11 rheumatology sites in the US. The intervention entailed a 9-month group-based LC that incorporated rapid-cycle improvement methods...
May 17, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28511787/comparative-and-cost-effectiveness-research-competencies-opportunities-and-training-for-nurse-scientists
#4
Patricia W Stone, Catherine Cohen, Harold Alan Pincus
BACKGROUND: Comparative and cost-effectiveness research develops knowledge on the everyday effectiveness and value of treatments and care delivery models. PURPOSE: To describe comparative and cost-effectiveness research; identify needed competencies for this research; identify federal funding; and describe current training opportunities. METHODS: Published recommended competencies were reviewed. Current federal funding and training opportunities were identified...
April 20, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28486711/momentary-associations-between-reported-craving-and-valuing-health-in-daily-smokers
#5
Robert Ross MacLean, Steve Martino, Kathleen M Carroll, Joshua M Smyth, Aaron L Pincus, Stephen J Wilson
Introduction: Research suggests that a blunted response to nondrug rewards, especially under conditions associated with strong cigarette cravings, is associated with reduced abstinence motivation in daily smokers. One limitation of previous studies is that they have largely focused on monetary rewards as broad representative of nondrug rewards. It remains unclear whether craving dampens responses to more abstract nondrug rewards, such as personal values. Personal values often have a positive valence and are frequently assumed to remain stable across time and situations...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28484401/psychotherapy-is-chaotic-not-only-in-a-computational-world
#6
Günter K Schiepek, Kathrin Viol, Wolfgang Aichhorn, Marc-Thorsten Hütt, Katharina Sungler, David Pincus, Helmut J Schöller
Objective: The aim of this article is to outline the role of chaotic dynamics in psychotherapy. Besides some empirical findings of chaos at different time scales, the focus is on theoretical modeling of change processes explaining and simulating chaotic dynamics. It will be illustrated how some common factors of psychotherapeutic change and psychological hypotheses on motivation, emotion regulation, and information processing of the client's functioning can be integrated into a comprehensive nonlinear model of human change processes...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28450760/psychological-assessment-with-the-dsm-5-alternative-model-for-personality-disorders-tradition-and-innovation
#7
Mark H Waugh, Christopher J Hopwood, Robert F Krueger, Leslie C Morey, Aaron L Pincus, Aidan G C Wright
The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) Section III Alternative Model for Personality Disorders (AMPD; APA, 2013) represents an innovative system for simultaneous psychiatric classification and psychological assessment of personality disorders (PD). The AMPD combines major paradigms of personality assessment and provides an original, heuristic, flexible, and practical framework that enriches clinical thinking and practice. Origins, emerging research, and clinical application of the AMPD for diagnosis and psychological assessment are reviewed...
April 2017: Professional Psychology, Research and Practice
https://www.readbyqxmd.com/read/28361107/remission-of-subcutaneous-panniculitis-like-t-cell-lymphoma-in-a-pregnant-woman-after-treatment-with-oral-corticosteroids-as-monotherapy
#8
Emily S West, Kanade Shinkai, Weiyun Z Ai, Laura B Pincus
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous T-cell lymphoma characterized by neoplastic α/β T cells infiltrating subcutaneous tissues in a lobular pattern. Few data support the optimal treatment regimen for patients, given the rarity of this condition, and even fewer data describe treatment when diagnosed during pregnancy. We describe a case of SPTCL in a pregnant patient who achieved clinical remission after treatment with corticosteroid monotherapy. Our case suggests that corticosteroids should be considered as first-line treatment in pregnant patients with SPTCL...
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28340902/quality-of-care-measures-for-the-management-of-unhealthy-alcohol-use
#9
Kimberly A Hepner, Katherine E Watkins, Carrie M Farmer, Lisa Rubenstein, Eric R Pedersen, Harold Alan Pincus
There is a paucity of quality measures to assess the care for the range of unhealthy alcohol use, ranging from risky drinking to alcohol use disorders. Using a two-phase expert panel review process, we sought to develop an expanded set of quality of care measures for unhealthy alcohol use, focusing on outpatient care delivered in both primary care and specialty care settings. This process generated 25 candidate measures. Eight measures address screening and assessment, 11 address aspects of treatment, and six address follow-up...
May 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28329860/modeling-intraindividual-dynamics-using-stochastic-differential-equations-age-differences-in-affect-regulation
#10
Julie Wood, Zita Oravecz, Nina Vogel, Lizbeth Benson, Sy-Miin Chow, Pamela Cole, David E Conroy, Aaron L Pincus, Nilam Ram
Objectives: Life-span theories of aging suggest improvements and decrements in individuals' ability to regulate affect. Dynamic process models, with intensive longitudinal data, provide new opportunities to articulate specific theories about individual differences in intraindividual dynamics. This paper illustrates a method for operationalizing affect dynamics using a multilevel stochastic differential equation (SDE) model, and examines how those dynamics differ with age and trait-level tendencies to deploy emotion regulation strategies (reappraisal and suppression)...
March 2, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28326802/the-relationship-between-beliefs-about-emotions-and-quality-of-life-in-irritable-bowel-syndrome
#11
Hannah Bowers, Abigail Wroe, Tamar Pincus
Suppression of undesirable emotions, as well as beliefs about the unacceptability of experiencing and expressing emotions, have both been shown to be related to poorer health-related outcomes in several clinical groups. Potential models through which these variables relate have yet to be tested in those with irritable bowel syndrome (IBS) and are therefore examined in the current article. Online questionnaires were administered to people with IBS (n = 84) to test a mediation model in which beliefs about the unacceptability of emotions are associated with greater emotional suppression, which in turn relates to increased affective distress and consequently poorer quality of life...
March 22, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28298051/a-systematic-review-and-appraisal-of-clinical-practice-guidelines-for-musculoskeletal-soft-tissue-injuries-and-conditions
#12
Daniel Pincus, John E Kuhn, Ujash Sheth, Katie Rizzone, Kristi Colbenson, Tim Dwyer, Ashley Karpinos, Paul H Marks, David Wasserstein
BACKGROUND: Clinical practice guidelines (CPGs) are published by several sports medicine institutions. A systematic evaluation can help identify the highest quality CPGs for clinical use and identify any deficiencies that remain. PURPOSE: To identify and appraise CPGs relevant to clinical sports medicine professionals. STUDY DESIGN: Systematic review. METHODS: Predetermined selection criteria were utilized by 2 reviewers who independently identified published CPGs before January 1, 2014...
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28266924/an-evolution-based-strategy-for-engineering-allosteric-regulation
#13
David Pincus, Orna Resnekov, Kimberly A Reynolds
Allosteric regulation provides a way to control protein activity at the time scale of milliseconds to seconds inside the cell. An ability to engineer synthetic allosteric systems would be of practical utility for the development of novel biosensors, creation of synthetic cell signaling pathways, and design of small molecule pharmaceuticals with regulatory impact. To this end, we outline a general approach-termed rational engineering of allostery at conserved hotspots (REACH)-to introduce novel regulation into a protein of interest by exploiting latent allostery that has been hard-wired by evolution into its structure...
April 28, 2017: Physical Biology
https://www.readbyqxmd.com/read/28257416/network-analysis-of-wildfire-transmission-and-implications-for-risk-governance
#14
Alan A Ager, Cody R Evers, Michelle A Day, Haiganoush K Preisler, Ana M G Barros, Max Nielsen-Pincus
We characterized wildfire transmission and exposure within a matrix of large land tenures (federal, state, and private) surrounding 56 communities within a 3.3 million ha fire prone region of central Oregon US. Wildfire simulation and network analysis were used to quantify the exchange of fire among land tenures and communities and analyze the relative contributions of human versus natural ignitions to wildfire exposure. Among the land tenures examined, the area burned by incoming fires averaged 57% of the total burned area...
2017: PloS One
https://www.readbyqxmd.com/read/28255740/-isn-t-it-ironic-beliefs-about-the-unacceptability-of-emotions-and-emotional-suppression-relate-to-worse-outcomes-in-fibromyalgia
#15
Hannah Bowers, Abigail L Wroe, Tamar Pincus
Beliefs about the unacceptability of experiencing and expressing emotions have been found to be related to worse outcomes in people with persistent physical symptoms. The current study tested mediation models regarding emotional suppression, beliefs about emotions, support-seeking and global impact in fibromyalgia. One hundred eighty-two participants took part in an online questionnaire testing potential mechanisms of this relationship using mediation analysis. The model tested emotional suppression and affective distress as serial mediators of the relationship between beliefs about emotions and global impact...
May 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28213145/how-are-you-feeling-a-personalized-methodology-for-predicting-mental-states-from-temporally-observable-physical-and-behavioral-information
#16
Suppawong Tuarob, Conrad S Tucker, Soundar Kumara, C Lee Giles, Aaron L Pincus, David E Conroy, Nilam Ram
It is believed that anomalous mental states such as stress and anxiety not only cause suffering for the individuals, but also lead to tragedies in some extreme cases. The ability to predict the mental state of an individual at both current and future time periods could prove critical to healthcare practitioners. Currently, the practical way to predict an individual's mental state is through mental examinations that involve psychological experts performing the evaluations. However, such methods can be time and resource consuming, mitigating their broad applicability to a wide population...
February 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28208462/beyond-flory-theory-distribution-functions-for-interacting-lattice-trees
#17
Angelo Rosa, Ralf Everaers
While Flory theories [J. Isaacson and T. C. Lubensky, J. Physique Lett. 41, 469 (1980)JPSLBO0302-072X10.1051/jphyslet:019800041019046900; M. Daoud and J. F. Joanny, J. Physique 42, 1359 (1981)JOPQAG0302-073810.1051/jphys:0198100420100135900; A. M. Gutin et al., Macromolecules 26, 1293 (1993)MAMOBX0024-929710.1021/ma00058a016] provide an extremely useful framework for understanding the behavior of interacting, randomly branching polymers, the approach is inherently limited. Here we use a combination of scaling arguments and computer simulations to go beyond a Gaussian description...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28185900/evidence-based-science-policy-for-mental-health-in-a-post-truth-era
#18
Harold Alan Pincus, Stephanie A Rolin
No abstract text is available yet for this article.
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28155002/the-relationship-between-pain-disability-guilt-and-acceptance-in-low-back-pain-a-mediation-analysis
#19
Danijela Serbic, Tamar Pincus
Pain-related guilt is a common yet unexplored psychological factor in low back pain (LBP). It has recently been linked to greater depression, anxiety and disability in LBP, hence an understanding of how it can be managed in the presence of pain and disability is necessary. Since acceptance of pain has been shown to be associated with improved outcomes in chronic pain, we examined whether it might also help reduce guilt in people with LBP. To this end, a series of mediation analyses were conducted on data from 287 patients with chronic LBP, in which acceptance of pain was tested as a mediator of the relationship between pain/disability and guilt...
February 2, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28142364/increasing-recreational-physical-activity-in-patients-with-chronic-low-back-pain-a-pragmatic-controlled-clinical-trial
#20
Noa Ben-Ami, Gabriel Chodick, Yigal Mirovsky, Tamar Pincus, Yair Shapiro
Study Design Prospective, pragmatic, nonrandomized controlled clinical trial. Background Clinical guidelines recommend physical activity for the treatment of chronic low back pain. But engaging patients in physical activity has proven difficult. Known obstacles to physical activity include low self-efficacy and fear avoidance. Objectives This study tested the effectiveness of an enhanced transtheoretical model intervention (ETMI) aimed at increasing recreational physical activity in patients with chronic low back pain, in comparison to usual physical therapy...
February 2017: Journal of Orthopaedic and Sports Physical Therapy
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