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https://www.readbyqxmd.com/read/29791195/psychometric-evaluation-of-the-inventory-of-interpersonal-problems-32
#1
Cassandra Bailey, Anna Abate, Carla Sharp, Amanda Venta
The Inventory of Interpersonal Problems 32 (IIP-32; Horowitz, Aiden, Wiggins, & Pincus, 2000) is a brief, 32-item, self-report questionnaire used to screen for interpersonal problems. While studies of the IIP-32's psychometric properties have been conducted in other nations, and studies have examined the psychometric properties of the IIP-32's circumplex structure, no studies have examined the factor-analytic structure in the United States since the original standardization sample. The aim of this study was to examine the psychometric properties of the IIP-32 in American college women for the first time and explore its structural validity as a circumplex measure and its concurrent validity with measures of attachment...
2018: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/29760078/chaperone-ampylation-modulates-aggregation-and-toxicity-of-neurodegenerative-disease-associated-polypeptides
#2
Matthias C Truttmann, David Pincus, Hidde L Ploegh
Proteostasis is critical to maintain organismal viability, a process counteracted by aging-dependent protein aggregation. Chaperones of the heat shock protein (HSP) family help control proteostasis by reducing the burden of unfolded proteins. They also oversee the formation of protein aggregates. Here, we explore how AMPylation, a posttranslational protein modification that has emerged as a powerful modulator of HSP70 activity, influences the dynamics of protein aggregation. We find that adjustments of cellular AMPylation levels in Caenorhabditis elegans directly affect aggregation properties and associated toxicity of amyloid-β (Aβ), of a polyglutamine (polyQ)-extended polypeptide, and of α-synuclein (α-syn)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29746190/criterion-a-of-the-ampd-in-hitop
#3
Thomas A Widiger, Bo Bach, Michael Chmielewski, Lee Anna Clark, Colin DeYoung, Christopher J Hopwood, Roman Kotov, Robert F Krueger, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, Christopher J Patrick, Aaron L Pincus, Douglas B Samuel, Martin Sellbom, Susan C South, Jennifer L Tackett, David Watson, Mark H Waugh, Aidan G C Wright, Johannes Zimmermann, R Michael Bagby, David C Cicero, Christopher C Conway, Barbara De Clercq, Anna R Docherty, Nicholas R Eaton, Kelsie T Forbush, J D Haltigan, Masha Y Ivanova, Robert D Latzman, Donald R Lynam, Kristian E Markon, Ulrich Reininghaus, Katherine M Thomas
The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013 ) is highly and fundamentally problematic. Proposed for DSM-5 and provided within Section III (for Emerging Measures and Models) was the Alternative Model of Personality Disorder (AMPD) classification, consisting of Criterion A (self-interpersonal deficits) and Criterion B (maladaptive personality traits)...
May 10, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29742552/subcutaneous-panniculitis-like-t-cell-lymphoma-versus-lupus-erythematosus-panniculitis-distinction-by-means-of-the-periadipocytic-cell-proliferation-index
#4
Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Jitsupa Treetipsatit, Tawatchai Pongpruttipan, Sanya Sukpanichnant, Laura B Pincus, Timothy H McCalmont
The distinction between subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus (LE) panniculitis is remarkably challenging. Rimming by lymphocytes with an elevated Ki-67 cell proliferation index has been forwarded as a potential diagnostic finding in biopsies of SPTCL but has not been rigorously compared with biopsies from patients with LE panniculitis. Nineteen and 17 examples of SPTCL and LE panniculitis, respectively, were evaluated for periadipocytic rimming by lymphocytes expressing Ki-67, CD8, and βF1 and for attributes associated with LE, including clusters of CD123-positive cells...
May 2, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29723070/examining-the-interpersonal-nature-of-criterion-a-of-the-dsm-5-section-iii-alternative-model-for-personality-disorders-using-bootstrapped-confidence-intervals-for-the-interpersonal-circumplex
#5
Emily A Dowgwillo, Michael J Roche, Aaron L Pincus
Criterion A of the alternative model of personality disorders (AMPD) involves the assessment of impairments in self and self in relation to other functioning and can be assessed using the Level of Personality Functioning Scale (LPFS). This study uses responses to a self-report version of the LPFS (AMPD-CAS) from 248 college students to examine the interpersonal implications of AMPD personality impairments using the interpersonal circumplex (IPC) as a nomological net. Results suggest that AMPD-CAS self-impairments are related to problems of low communion and interpersonal distress and do not appear to tap expected interpersonal problems of low agency...
May 3, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29712542/2017-jospt-award-recipients
#6
Guy G Simoneau
During the American Physical Therapy Association's Combined Sections Meeting in New Orleans, LA in February 2018, JOSPT recognized the authors of the most outstanding research and clinical practice manuscripts published in JOSPT during 2017. The 2017 George J. Davies-James A. Gould Excellence in Clinical Inquiry Award was presented to Noa Ben-Ami, PT, PhD; Gabriel Chodick, MHA, PhD; Yigal Mirovsky, MD; Tamar Pincus, MPhil, MSc, PhD; and Yair Shapiro, MD, PhD, for their February 2017 article "Increasing Recreational Physical Activity in Patients With Chronic Low Back Pain: A Pragmatic Controlled Clinical Trial...
May 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29659006/health-and-aging-policy-fellows-dementia-and-mental-health-policy-to-improve-lives-of-older-adults
#7
Pamela Z Cacchione, Kathleen M Pike, Brigitta Spaeth-Rublee, Harrold A Pincus
The Health and Aging Policy Fellows (HAPF) Program has, since its inception in 2008, provided health policy training and mentorship for 113 gerontological professionals across a wide range of disciplines and stages of careers. The fellows' shared passion is the effective engagement of policy levers to improve the lives of older adults. This article briefly describes the HAPF Program and provides a sample of policies with which fellows have been engaged related to dementia and late-life mental health. Approximately 20% of the fellows have specifically addressed one of these areas during their fellowship year...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29643158/is-an-enhanced-behaviour-change-intervention-cost-effective-compared-with-physiotherapy-for-patients-with-chronic-low-back-pain-results-from-a-multicentre-trial-in-israel
#8
Alastair Canaway, Tamar Pincus, Martin Underwood, Yair Shapiro, Gabriel Chodick, Noa Ben-Ami
OBJECTIVE: To assess the cost-effectiveness of an enhanced transtheoretical model of behaviour change in conjunction with physiotherapy compared with standard care (physiotherapy) in patients with chronic lower back pain (CLBP). DESIGN: Cost-utility and cost-effectiveness analyses alongside a multicentre controlled trial from a healthcare perspective with a 1-year time horizon. SETTING: The trial was conducted in eight centres within the Sharon district in Israel...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29607248/quality-of-care-for-ptsd-and-depression-in-the-military-health-system-final-report
#9
Kimberly A Hepner, Carol P Roth, Elizabeth M Sloss, Susan M Paddock, Praise O Iyiewuare, Martha J Timmer, Harold Alan Pincus
The U.S. Department of Defense (DoD) strives to maintain a physically and psychologically healthy, mission-ready force, and the care provided by the Military Health System (MHS) is critical to meeting this goal. Attention has been directed to ensuring the quality and availability of programs and services for posttraumatic stress disorder (PTSD) and depression. This study is a comprehensive assessment of the quality of care delivered by the MHS in 2013-2014 for over 38,000 active-component service members with PTSD or depression...
April 2018: Rand Health Quarterly
https://www.readbyqxmd.com/read/29607247/delivering-clinical-practice-guideline-concordant-care-for-ptsd-and-major-depression-in-military-treatment-facilities
#10
Kimberly A Hepner, Coreen Farris, Carrie M Farmer, Praise O Iyiewuare, Terri Tanielian, Asa Wilks, Michael Robbins, Susan M Paddock, Harold Alan Pincus
Providing accessible, high-quality care for psychological health (PH) conditions, such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), is important to maintaining a healthy, mission-ready force. It is unclear whether the current system of care meets the needs of service members with PTSD or MDD, and little is known about the barriers to delivering guideline-concordant care. RAND used existing provider workforce data, a provider survey, and key informant interviews to (1) provide an overview of the PH workforce at military treatment facilities (MTFs), (2) examine the extent to which care for PTSD and MDD in military treatment facilities is consistent with Department of Veterans Affairs/Department of Defense clinical practice guidelines, and (3) identify facilitators and barriers to providing this care...
April 2018: Rand Health Quarterly
https://www.readbyqxmd.com/read/29595316/double-equivocal-her2-invasive-breast-carcinomas-institutional-experience-and-review-of-literature
#11
Brannan B Griffin, Jennifer L Pincus, Kalliopi P Siziopikou, Luis Z Blanco
Context HER2 status is a prognostic factor and therapeutic target in invasive breast carcinomas. Reflex testing using an alternate method is recommended on equivocal cases via immunohistochemistry or fluorescence in situ hybridization (FISH). Therapeutic dilemmas arise when both tests are equivocal. The standard chromosome 17 centromere reference probe (CEP17) is in close proximity to the HER2 locus and may be coamplified, leading to equivocal results. Alternate chromosome 17 reference probes may aid in establishing the true HER2 status...
March 29, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29587572/outcomes-in-distressed-patients-with-chronic-low-back-pain-subgroup-analysis-of-a-clinical-trial
#12
Noa Ben-Ami, Yair Shapiro, Tamar Pincus
Study Design Subgroup analysis of a controlled clinical trial. Background Current evidence suggests that people with chronic low back pain who are distressed may require different interventions than do those who are not distressed. Recently, the enhanced transtheoretical model intervention (ETMI) reported significant improvements in disability and pain and increased physical activity in patients with chronic low back pain compared to physical therapy as usual. Objectives To compare outcomes between ETMI and physical therapy interventions for participants with and without self-reported distress...
March 27, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29567621/diet-matters-glucocorticoid-related-neuroadaptations-associated-with-calorie-intake-in-female-rhesus-monkeys
#13
Jodi R Godfrey, Maylen Perez Diaz, Melanie Pincus, Zsofia Kovacs-Balint, Eric Feczko, Eric Earl, Oscar Miranda-Dominguez, Damien Fair, Mar M Sanchez, Mark E Wilson, Vasiliki Michopoulos
Exposure to psychosocial stressors increases consumption of palatable, calorically dense diets (CDD) and the risk for obesity, especially in females. While consumption of an obesogenic diet and chronic stress have both been shown to decrease dopamine 2 receptor (D2R) binding and alter functional connectivity (FC) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc), it remains uncertain how social experience and dietary environment interact to affect reward pathways critical for the regulation of motivated behavior...
March 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29562166/hsf1-phosphorylation-generates-cell-to-cell-variation-in-hsp90-levels-and-promotes-phenotypic-plasticity
#14
Xu Zheng, Ali Beyzavi, Joanna Krakowiak, Nikit Patel, Ahmad S Khalil, David Pincus
Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a population. Heat shock factor 1 (Hsf1) regulates chaperone gene expression, thereby coupling transcriptional noise to proteostasis. Here we show that cell-to-cell variation in Hsf1 activity is an important determinant of phenotypic plasticity. Budding yeast cells with high Hsf1 activity were enriched for the ability to acquire resistance to an antifungal drug, and this enrichment depended on Hsp90, a known phenotypic capacitor and canonical Hsf1 target...
March 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29543675/the-use-of-central-pathology-review-with-digital-slide-scanning-in-advanced-stage-mycosis-fungoides-and-s%C3%A3-zary-syndrome-a-multi-institutional-and-international-pathology-study
#15
Alejandro A Gru, Jinah Kim, Melissa Pulitzer, Joan Guitart, Maxime Battistella, Gary S Wood, Lorenzo Cerroni, Werner Kempf, Rein Willemze, Joya Pawade, Christiane Querfeld, Andras Schaffer, Laura Pincus, Michael Tetzlaff, Madeleine Duvic, Julia Scarisbrick, Pierluigi Porcu, Aaron R Mangold, David J DiCaudo, Michi Shinohara, Eric K Hong, Bethany Horton, Youn H Kim
This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29543483/communication-of-military-couples-during-deployment-predicting-generalized-anxiety-upon-reunion
#16
Leanne K Knobloch, Lynne M Knobloch-Fedders, Jeremy B Yorgason
This study draws on the emotional cycle of deployment model (Pincus, House, Christenson, & Adler, 2001) to consider how the valence of communication between military personnel and at-home partners during deployment predicts their generalized anxiety upon reunion. Online survey data were collected from 555 military couples (N = 1,110 individuals) once per month for 8 consecutive months beginning at homecoming. Dyadic growth curve modeling results indicated that people's anxiety declined across the transition...
February 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29526462/translocon-declogger-ste24-protects-against-iapp-oligomer-induced-proteotoxicity
#17
Can Kayatekin, Audra Amasino, Giorgio Gaglia, Jason Flannick, Julia M Bonner, Saranna Fanning, Priyanka Narayan, M Inmaculada Barrasa, David Pincus, Dirk Landgraf, Justin Nelson, William R Hesse, Michael Costanzo, Chad L Myers, Charles Boone, Jose C Florez, Susan Lindquist
Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type 2 diabetes (T2D) are thought to contribute to β cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a yeast model of IAPP toxicity. Ste24, an evolutionarily conserved protease that was recently reported to degrade peptides stuck within the translocon between the cytoplasm and the endoplasmic reticulum, was the strongest suppressor of IAPP toxicity. By testing variants of the human homolog, ZMPSTE24, with varying activity levels, the rescue of IAPP toxicity proved to be directly proportional to the declogging efficiency...
March 22, 2018: Cell
https://www.readbyqxmd.com/read/29514100/coupling-of-rigor-mortis-and-intestinal-necrosis-during-c-elegans-organismal-death
#18
Evgeniy R Galimov, Rosina E Pryor, Sarah E Poole, Alexandre Benedetto, Zachary Pincus, David Gems
Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29509169/testing-a-model-of-consultation-based-reassurance-and-back-pain-outcomes-with-psychological-risk-as-moderator-a-prospective-cohort-study
#19
Nicola Holt, Gemma Mansell, Jonathan C Hill, Tamar Pincus
OBJECTIVES: Reassurance is an essential part of treatment for low back pain (LBP), but evidence on effective methods to deliver reassurance remains scarce. The interaction between consultation-based reassurance and patients' psychological risk is unknown. Our objective was to investigate the relationship between consultation-based reassurance and clinical outcomes at follow-up, in people with and without psychological risk. METHODS: We tested the associations between specific reassurance components (data gathering, relationship building, generic reassurance, and cognitive reassurance), patients' psychological risk (the presence of depression, anxiety, catastrophizing, or fear-avoidance), and postconsultation outcomes including, satisfaction and enablement, disability, pain, and mood at 3-month follow-up...
April 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29488052/integrating-behavioral-health-and-primary-care-services-for-people-with-serious-mental-illness-a-qualitative-systems-analysis-of-integration-in-new-york
#20
Parashar Pravin Ramanuj, Rachel Talley, Joshua Breslau, Scarlett Sijia Wang, Harold Alan Pincus
People with co-occurring behavioral and physical conditions receive poorer care through traditional health care services. One solution has been to integrate behavioral and physical care services. This study assesses efforts to integrate behavioral health and primary care services in New York. Semi-structured interviews were conducted with 52 professionals in either group or individual settings. We aimed to identify factors which facilitate or hinder integration for people with serious mental illness and how these factors inter-relate...
February 27, 2018: Community Mental Health Journal
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