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https://www.readbyqxmd.com/read/28099971/warfarin-associated-nonuremic-calciphylaxis
#1
Wesley Yung-Hsu Yu, Tina Bhutani, Rachel Kornik, Laura B Pincus, Theodora Mauro, Michael D Rosenblum, Lindy P Fox
Importance: Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated calciphylaxis, present data from 2 others from our institution, and review all cases of warfarin-associated calciphylaxis available in the literature. Our review indicates that warfarin-associated calciphylaxis is clinically and pathophysiologically distinct from classic calciphylaxis...
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28077221/interpersonal-problems-predict-differential-response-to-cognitive-versus-behavioral-treatment-in-a-randomized-controlled-trial
#2
Michelle G Newman, Nicholas C Jacobson, Thane M Erickson, Aaron J Fisher
OBJECTIVE: We examined dimensional interpersonal problems as moderators of cognitive behavioral therapy (CBT) versus its components (cognitive therapy [CT] and behavioral therapy [BT]). We predicted that people with generalized anxiety disorder (GAD) whose interpersonal problems reflected more dominance and intrusiveness would respond best to a relaxation-based BT compared to CT or CBT, based on studies showing that people with personality features associated with a need for autonomy respond best to treatments that are more experiential, concrete, and self-directed compared to therapies involving abstract analysis of one's problems (e...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28065463/primary-cutaneous-b-cell-lymphomas-with-large-cell-predominance-primary-cutaneous-follicle-center-lymphoma-diffuse-large-b-cell-lymphoma-leg-type-and-intravascular-large-b-cell-lymphoma
#3
Charity B Hope, Laura B Pincus
In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.(1,2) Overall, B-cell lymphomas represent 19-27% of primary cutaneous lymphomas in most large European and American studies(3-6) and together, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type account for approximately 2/3 to ¾ of these cases...
December 2, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28031489/unrestrained-ampylation-targets-cytosolic-chaperones-and-activates-the-heat-shock-response
#4
Matthias C Truttmann, Xu Zheng, Leo Hanke, Jadyn R Damon, Monique Grootveld, Joanna Krakowiak, David Pincus, Hidde L Ploegh
Protein AMPylation is a conserved posttranslational modification with emerging roles in endoplasmic reticulum homeostasis. However, the range of substrates and cell biological consequences of AMPylation remain poorly defined. We expressed human and Caenorhabditis elegans AMPylation enzymes-huntingtin yeast-interacting protein E (HYPE) and filamentation-induced by cyclic AMP (FIC)-1, respectively-in Saccharomyces cerevisiae, a eukaryote that lacks endogenous protein AMPylation. Expression of HYPE and FIC-1 in yeast induced a strong cytoplasmic Hsf1-mediated heat shock response, accompanied by attenuation of protein translation, massive protein aggregation, growth arrest, and lethality...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27996111/growing-old-or-just-growing
#5
Harold Alan Pincus
No abstract text is available yet for this article.
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27993876/emerging-role-of-mdm2-as-target-for-anti-cancer-therapy-a-review
#6
REVIEW
Mohammad F Shaikh, William F Morano, John Lee, Elizabeth Gleeson, Blake D Babcock, Josef Michl, Ehsan Sarafraz-Yazdi, Matthew R Pincus, Wilbur B Bowne
The mouse/murine protein, MDM2, and its human homolog, HDM2, are important negative regulators of the p53 tumor suppressor protein. In normal, untransformed cells, MDM2 levels are tightly regulated to control expression of p53 and apoptosis. Conversely, MDM2 expression appears inherently higher in multiple types of cancer cells, thereby supporting its role as a suppressor of p53 pro-apoptotic activity. MDM2 amplification ranges between two- and ten-fold as reported in brain, breast, lung, and soft tissue tumors...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27974005/carrots-and-sticks-on-opposite-sides-of-the-atlantic-integration-incentives-for-people-with-serious-mental-illness-in-england
#7
Parashar Pravin Ramanuj, Joshua Breslau, Geraldine Strathdee, Brigitta Spaeth-Rublee, Harold Alan Pincus
Integrating care pathways between primary and specialist mental health care is seen as integral to improving the health of people with mental illness. Multiple integration initiatives have been implemented, but few have tried to integrate care for people with serious mental illness. This column describes two such initiatives in the United States and in England. The two schemes are compared according to the population they target, payment mechanisms, accountability structures, service delivery, outcomes, and lessons learned...
December 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27964750/laminin-521-maintains-differentiation-potential-of-mouse-and-human-satellite-cell-derived-myoblasts-during-long-term-culture-expansion
#8
Christopher M Penton, Vasudeo Badarinarayana, Joy Prisco, Elaine Powers, Mark Pincus, Ronald E Allen, Paul R August
BACKGROUND: Large-scale expansion of myogenic progenitors is necessary to support the development of high-throughput cellular assays in vitro and to advance genetic engineering approaches necessary to develop cellular therapies for rare muscle diseases. However, optimization has not been performed in order to maintain the differentiation capacity of myogenic cells undergoing long-term cell culture. Multiple extracellular matrices have been utilized for myogenic cell studies, but it remains unclear how different matrices influence long-term myogenic activity in culture...
December 13, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27956939/a-review-of-mental-health-recovery-programs-in-selected-industrialized-countries
#9
REVIEW
Harold A Pincus, Brigitta Spaeth-Rublee, Grant Sara, Elliot M Goldner, Pamela N Prince, Parashar Ramanuj, Wolfgang Gaebel, Jürgen Zielasek, Isabell Großimlinghaus, Margo Wrigley, Jaap van Weeghel, Mark Smith, Torleif Ruud, John R Mitchell, Lisa Patton
The concept of recovery has gained increasing attention and many mental health systems have taken steps to move towards more recovery oriented practice and service structures. This article represents a description of current recovery-oriented programs in participating countries including recovery measurement tools. Although there is growing acceptance that recovery needs to be one of the key domains of quality in mental health care, the implementation and delivery of recovery oriented services and corresponding evaluation strategies as an integral part of mental health care have been lacking...
2016: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/27926849/effects-of-dimethyl-sulfoxide-on-surface-water-near-phospholipid-bilayers
#10
Yuno Lee, Philip A Pincus, Changbong Hyeon
Despite much effort to probe the properties of dimethyl sulfoxide (DMSO) solution, the effects of DMSO on water, especially near plasma membrane surfaces, still remain elusive. By performing molecular dynamics simulations at varying DMSO concentrations (XDMSO), we study how DMSO affects structural and dynamical properties of water in the vicinity of phospholipid bilayers. As proposed by a number of experiments, our simulations confirm that DMSO induces dehydration from bilayer surfaces and disrupts the H-bond structure of water...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27907833/development-of-a-scale-to-evaluate-young-children-s-responses-to-uncertainty-and-low-environmental-structure
#11
Amanda L Sanchez, Danielle Cornacchio, Tommy Chou, Ovsanna Leyfer, Stefany Coxe, Donna Pincus, Jonathan S Comer
Intolerance of Uncertainty (IU), defined as the dispositional interpretation of uncertain or ambiguous events as stressful and problematic, has been linked to excessive worry and other anxiety-related problems in adults and youth. IU has been conceptualized as a vulnerability factor for excessive worry and anxiety, but the historical absence of a supported measure of IU in young children has hampered longitudinal research needed to evaluate temporal relationships between IU and anxiety and the differential developmental pathways of IU leading to different anxiety disorders and depression...
November 21, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27893225/correction-to-fossati-et-al-2016
#12
(no author information available yet)
Reports an error in "Profiling Pathological Narcissism According to DSM-5 Domains and Traits: A Study on Consecutively Admitted Italian Psychotherapy Patients" by Andrea Fossati, Antonella Somma, Serena Borroni, Aaron L. Pincus, Kristian E. Markon and Robert F. Krueger (Psychological Assessment, Advanced Online Publication, Jun 23, 2016, np). In the original article, several values were reversed and the mean was misreported in Table 2. The corrected Table 2 is provided in the erratum. (The following abstract of the original article appeared in record 2016-31181-001...
November 28, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27869467/how-the-social-ecology-and-social-situation-shape-individuals-affect-valence-and-arousal
#13
Nina Vogel, Nilam Ram, David E Conroy, Aaron L Pincus, Denis Gerstorf
Many theories highlight the role social contexts play in shaping affective experience. However, little is known about how individuals' social environments influence core affect on short time-scales (e.g., hours). Using experience sampling data from the iSAHIB, wherein 150 adults aged 18 to 89 years reported on 64,213 social interactions (average 6.92 per day, SD = 2.85) across 9 weeks of daily life, we examined how 4 features of individuals' social ecology (between-person differences) and immediate social situations (within-person changes) were associated with core affect-valence and arousal-and how those associations differ with age...
November 21, 2016: Emotion
https://www.readbyqxmd.com/read/27855541/relaxation-induced-anxiety-effects-of-peak-and-trajectories-of-change-on-treatment-outcome-for-generalized-anxiety-disorder
#14
Michelle G Newman, Lucas S Lafreniere, Nicholas C Jacobson
OBJECTIVE: Evidence is mixed regarding whether relaxation-induced anxiety (RIA) impedes relaxation training (RT) efficacy. Unlike past studies that averaged RIA across sessions, we examined peak RIA, change in RIA level across sessions, and timing of peak RIA with outcome. METHOD: This was a secondary analysis of Borkovec, Newman, Pincus, and Lytle [2002. A component analysis of cognitive-behavioral therapy for generalized anxiety disorder and the role of interpersonal problems...
November 18, 2016: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/27852851/identification-of-human-anti-hiv-gp160-monoclonal-antibodies-that-make-effective-immunotoxins
#15
Seth H Pincus, Kejing Song, Grace A Maresh, Dean H Hamer, Dimiter S Dimitrov, Weizao Chen, Mei-Yun Zhang, Victor F Ghetie, Po-Ying Chan-Hui, James E Robinson, Ellen S Vitetta
: The envelope (Env) glycoprotein of HIV is the only intact viral protein expressed on the surface of both virions and infected cells. Env is the target of neutralizing antibodies (Abs) and has been the subject of intense study in efforts to produce HIV vaccines. Therapeutic anti-Env Abs can also exert antiviral effects via Fc-mediated effector mechanisms or as cytotoxic immunoconjugates, such as immunotoxins (ITs). In the course of screening monoclonal antibodies (MAbs) for their ability to deliver cytotoxic agents to infected or Env-transfected cells, we noted disparities in their functional activities...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27852349/the-relationship-between-worry-and-dimensions-of-anxiety-symptoms-in-children-and-adolescents
#16
Jonathan Rabner, Nicholas D Mian, David A Langer, Jonathan S Comer, Donna Pincus
BACKGROUND: Worry is a common feature across many anxiety disorders. It is important to understand how and when worry presents from childhood to adolescence to prevent long-term negative outcomes. However, most of the existing studies that examine the relationship between worry and anxiety disorders utilize adult samples. AIMS: The present study aimed to assess the level of worry in children and adolescents and how relationships between worry and symptoms of separation anxiety disorder (SAD) and social anxiety disorder (Soc) may present differently at different ages...
November 17, 2016: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/27842782/narcotic-analgesics-and-common-drugs-of-abuse-clinical-correlations-and-laboratory-assessment
#17
REVIEW
Martin H Bluth, Matthew R Pincus
Pain management is an evolving discipline. New formulations mature with promises of improved pain control, better dosing, and fewer side effects. These agents also have an equal risk for abuse. Street chemists are adept at manipulating drugs to more potent versions and creating new compositions of matter. The clinical assessment of the patient is paramount to developing an index of suspicion of overdose, toxicity, or illicit drug use; the clinical laboratory can be a resource to support investigations and guide therapy...
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27837499/commercial-molecular-tests-for-fungal-diagnosis-from-a-practical-point-of-view
#18
Michaela Lackner, Cornelia Lass-Flörl
The increasing interest in molecular diagnostics is a result of tremendously improved knowledge on fungal infections in the past 20 years and the rapid development of new methods, in particular polymerase chain reaction. High expectations have been placed on molecular diagnostics, and the number of laboratories now using the relevant technology is rapidly increasing-resulting in an obvious need for standardization and definition of laboratory organization. In the past 10 years, multiple new molecular tools were marketed for the detection of DNA, antibodies, cell wall components, or other antigens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27831465/dynamic-control-of-hsf1-during-heat-shock-by-a-chaperone-switch-and-phosphorylation
#19
Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus
Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in budding yeast, Hsf1 basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 activity. We develop and experimentally validate a mathematical model of Hsf1 activation by heat shock in which unfolded proteins compete with Hsf1 for binding to Hsp70...
November 10, 2016: ELife
https://www.readbyqxmd.com/read/27819470/using-repeated-daily-assessments-to-uncover-oscillating-patterns-and-temporally-dynamic-triggers-in-structures-of-psychopathology-applications-to-the-dsm-5-alternative-model-of-personality-disorders
#20
Michael J Roche, Nicholas C Jacobson, Aaron L Pincus
Articulating an accurate and clinically useful structure of psychopathology is a crucial and difficult task. Dimensions identified through cross-sectional factor analyses are increasingly being linked with temporally dynamic processes of social cognition, emotion regulation, symptom expression, and functional impairment to demonstrate how between-person structures and within-person dynamics can be integrated. The present research considers how structure and processes are integrated in the DSM-5, specifically in the alternative model for personality disorders (AMPD)...
November 2016: Journal of Abnormal Psychology
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