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Daniel Pincus, David Wasserstein, Avery B Nathens, Yu Qing Bai, Donald A Redelmeier, Walter P Wodchis
BACKGROUND: There is no reliable estimate of costs incurred by motorcycle crashes. Our objective was to calculate the direct costs of all publicly funded medical care provided to individuals after motorcycle crashes compared with automobile crashes. METHODS: We conducted a population-based, matched cohort study of adults in Ontario who presented to hospital because of a motorcycle or automobile crash from 2007 through 2013. For each case, we identified 1 control absent a motor vehicle crash during the study period...
November 20, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Lauren Watson, David Cartwright, Luke A Jardine, David Pincus, Pieter Koorts, Sebastien Kury, Stephanie Bezieau, Shane George, Susan Moloney, Johanna Holt, David Coman
No abstract text is available yet for this article.
November 16, 2017: Journal of Paediatrics and Child Health
Sachi Inukai, Zachary Pincus, Alexandre de Lencastre, Frank J Slack
Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing during C. elegans aging. We found that miRNA biogenesis genes are highly networked with transcription factors and aging-associated miRNAs. In particular, miR-71, known to influence lifespan and itself upregulated during aging, represses alg-1/Argonaute expression post-transcriptionally during aging...
November 7, 2017: RNA
Laura C Coates, William Tillett, Gavin Shaddick, Theodore Pincus, Arthur Kavanaugh, Philip S Helliwell
OBJECTIVE: To analyze RAPID3, a patient-reported, composite index, designed initially for feasibility in clinical care. RAPID3 was developed in rheumatoid arthritis, but has been found useful in many rheumatic diseases. We analysed RAPID3 in patients with psoriatic arthritis (PsA). METHODS: Post-hoc analyses were performed on two independent datasets, the tight control of PsA (TICOPA) clinical trial, and the long-term outcome in PsA study (LOPAS II), an observational cohort...
November 7, 2017: Arthritis Care & Research
Xu Zheng, David Pincus
This method was generated to isolate high affinity protein complexes from yeast lysate by performing serial affinity purification of doubly tagged 3×FLAG/V5 proteins. First, the bait protein of interest is immunoprecipitated by anti-FLAG-conjugated magnetic beads and gently eluted by 3×FLAG antigen peptide. Next, the bait protein is recaptured from the first eluate by anti-V5-conjugated magnetic beads and eluted with ionic detergent. In this manner, the majority of abundant, nonspecific proteins remain either bound to the first beads or in the first eluate, allowing pure, high affinity complexes to be obtained...
June 20, 2017: Bio-protocol
Hannah Brown, Helen L Barrett, Julie Lee, Jason M Pincus, Rebecca M Kimble, Victoria A Eley
We present a case of maternal cardiac arrest during an elective cesarean delivery. Transesophageal echocardiography identified a large pulmonary artery mass, and guided resuscitation efforts. After return of spontaneous circulation, the patient developed disseminated intravascular coagulation with massive hemorrhage. Blood product selection and volume replacement were guided by rotational thromboelastometry and transesophageal echocardiography, respectively. Correction of coagulopathy was observed clinically and confirmed by rotational thromboelastometry...
October 26, 2017: A & A Case Reports
William E Pittman, Drew B Sinha, William B Zhang, Holly E Kinser, Zachary Pincus
We have miniaturized standard culture techniques to rear arrays of isolated, individual C. elegans throughout their lives on solid gel media. The resulting apparatus is compatible with brightfield and fluorescence microscopy, enabling longitudinal studies of morphology and fluorescent transgene expression. Our culture system exploits a novel crosslinking reaction between a polyethylene glycol hydrogel and a silicone elastomer to constrain animals to individual "corrals" on the gel surface. These devices are simple to construct on the benchtop with commercially available reagents, and, unlike microfluidic isolation methods, do not rely on micropatterned materials...
November 7, 2017: Lab on a Chip
Danielle Cooper, Timothy Anderson
Although social anxiety disorder is defined by anxiety-related symptoms, little research has focused on the interpersonal features of social anxiety. Prior studies (Cain, Pincus, & Grosse Holtforth, 2010; Kachin, Newman, & Pincus, 2001) identified distinct subgroups of socially anxious individuals' interpersonal circumplex problems that were blends of agency and communion, and yet inconsistencies remain. We predicted 2 distinct interpersonal subtypes would exist for individuals with high social anxiety, and that these social anxiety subtypes would differ on empathetic concern, paranoia, received peer victimization, perspective taking, and emotional suppression...
October 5, 2017: Journal of Personality Assessment
Rachel Koffer, Johanna Drewelies, David M Almeida, David E Conroy, Aaron L Pincus, Denis Gerstorf, Nilam Ram
BACKGROUND: General and situational control beliefs have been examined separately as buffers of the effects of daily stressors on affective well-being. However, general (trait) control beliefs reflect perceived ability to adapt, change, and influence overall life circumstances, whereas situational (daily) control beliefs reflect perceived ability to manage current circumstances and achieve desired outcomes. METHOD: Using 9 weeks of daily reports from 150 adults aged 18-89 years, we examined the extent that general and daily control beliefs buffer the between- and within-person associations involving stressors and negative and positive affect (i...
June 21, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Anne-Marie Malfait, Theodore Pincus
No abstract text is available yet for this article.
September 2017: Clinical and Experimental Rheumatology
Isabel Castrejón, Jacquelin R Chua, Theodore Pincus
A physician global assessment of patient status (DOCGL) was designed initially to quantitate inflammatory activity in rheumatoid arthritis (RA) clinical trials, in which patients are selected for high levels of activity. However, in patients seen in routine care with various diagnoses, and even in some RA patients selected for clinical trials, DOCGL also may be affected by joint damage and/or patient distress. To clarify DOCGL on a 0-10 visual analogue scale (VAS), 3 additional 0-10 VAS have been developed to record physician estimates of inflammation (DOCINF), damage (DOCDAM), and distress (DOCSTR) (such as fibromyalgia (FM)/depression)...
September 2017: Clinical and Experimental Rheumatology
Jacquelin R Chua, Kathryn A Gibson, Theodore Pincus
OBJECTIVES: Osteoarthritis (OA) is regarded as a less severe form of arthritis than rheumatoid arthritis (RA) by health professionals and the general public, based largely on laboratory findings of autoantibodies and acute phase reactants. Relatively few studies have reported data from the patient's perspective to compare directly OA versus RA using the same self-report questionnaire measure. We aimed to summarise reports that compare OA versus RA patient pain scores and other indicators of disease burden according to the same self-report questionnaire...
September 2017: Clinical and Experimental Rheumatology
Jacquelin R Chua, Isabel Castrejon, Theodore Pincus
Pain is the most common basis for visits to a rheumatologist, and reduction of pain is a primary goal of clinical care. Pain is assessed optimally by the patient on a self-report questionnaire. In clinical trials and other clinical research concerning pain and pain relief, detailed questionnaires are generally completed by patients. However, in routine clinical care, pain is generally assessed only according to narrative descriptions by the physician, and only a minority of settings assess pain using a standard, quantitative measure...
September 2017: Clinical and Experimental Rheumatology
Nilam Ram, Lizbeth Benson, Timothy R Brick, David E Conroy, Aaron L Pincus
Contemporary views of personality highlight intraindividual variability. We forward a general method for quantifying individual differences in behavioral tendencies based on Earth Mover's Distance. Using data from 150 individuals who reported on their and others' interpersonal behavior in 64,112 social interactions, we illustrate how this new approach can advance notions of personality as density distributions. Results provide independent confirmation and establish validity of existing representations of individual differences in interpersonal behavior, and identify new dimensions and profiles of personality and well-being...
August 2017: Journal of Research in Personality
Joyce Yu, Kathleen Pincus, T Joseph Mattingly
At care transitions, patients are susceptible to adverse events and medication errors that can lead to harm or hospital readmission. This study describes the services provided by an interprofessional discharge clinic (IDC) aimed to improve these transitions and the impact on 30-day readmission rate, medication errors, and interventions documented. Data were collected retrospectively using an electronic medical record and analysed using SAS data system. Among 167 discharged patients, 154 patients were seen by a physician only (PO) and 13 patients were seen in the IDC...
September 28, 2017: Journal of Interprofessional Care
Alan J Forster, Burnand Bernard, Saskia E Drösler, Yana Gurevich, James Harrison, Jean-Marie Januel, Patrick S Romano, Danielle A Southern, Vijaya Sundararajan, Hude Quan, Saskia E Vanderloo, Harold A Pincus, William A Ghali
Objective: To assess the utility of the proposed World Health Organization (WHO)'s International Classification of Disease (ICD) framework for classifying patient safety events. Setting: Independent classification of 45 clinical vignettes using a web-based platform. Study participants: The WHO's multi-disciplinary Quality and Safety Topic Advisory Group. Main outcome measure(s): The framework consists of three concepts: harm, cause and mode...
August 1, 2017: International Journal for Quality in Health Care
Aaron L Pincus
This paper links Criterion A of the Diagnostic and Statistical Manual of Mental Disorders-5th Edition Alternative Model for Personality Disorders with the contemporary interpersonal model of personality pathology. Advances in interpersonal theory and assessment are outlined to demonstrate that Criterion A's self (identity, self-direction) and interpersonal (empathy, intimacy) impairments are related to the interpersonal meta-constructs and agency and communion and are operationalized by perceptual, behavioral, and affective mechanisms of the interpersonal situation framework...
September 16, 2017: Current Opinion in Psychology
Joshua Breslau, Emily Leckman-Westin, Hao Yu, Bing Han, Riti Pritam, Diana Guarasi, Marcela Horvitz-Lennon, Deborah M Scharf, Harold A Pincus, Molly T Finnerty
We examine the impact of mental health based primary care on physical health treatment among community mental health center patients in New York State using propensity score adjusted difference in difference models. Outcomes are quality indicators related to outpatient medical visits, diabetes HbA1c monitoring, and metabolic monitoring of antipsychotic treatment. Results suggest the program improved metabolic monitoring for patients on antipsychotics in one of two waves, but did not impact other quality indicators...
September 7, 2017: Administration and Policy in Mental Health
Katherine E Watkins, Allison J Ober, Karen Lamp, Mimi Lind, Claude Setodji, Karen Chan Osilla, Sarah B Hunter, Colleen M McCullough, Kirsten Becker, Praise O Iyiewuare, Allison Diamant, Keith Heinzerling, Harold Alan Pincus
Importance: Primary care offers an important and underutilized setting to deliver treatment for opioid and/or alcohol use disorders (OAUD). Collaborative care (CC) is effective but has not been tested for OAUD. Objective: To determine whether CC for OAUD improves delivery of evidence-based treatments for OAUD and increases self-reported abstinence compared with usual primary care. Design, Setting, and Participants: A randomized clinical trial of 377 primary care patients with OAUD was conducted in 2 clinics in a federally qualified health center...
October 1, 2017: JAMA Internal Medicine
Joshua Breslau, J Scott Ashwood, Courtney Ann Kase, Harold Alan Pincus, Susan L Lovejoy
This article provides information and recommendations regarding the evaluation design of the Certified Community Behavioral Health Clinic (CCBHC) demonstration. Mandated by Congress in Section 223 of the Protecting Access to Medicare Act of 2014, the CCBHC is a new model of specialty behavioral health clinic, designed to provide comprehensive and integrated care for adults with mental health or substance-use disorders and children with serious emotional distress. Certification criteria for the CCBHCs have been specified by Substance Abuse and Mental Health Services Administration covering six core areas: staffing; accessibility; care coordination; scope of services; quality and other reporting; and organizational authority, governance, and accreditation...
June 2017: Rand Health Quarterly
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