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https://www.readbyqxmd.com/read/27919281/incidence-causes-and-consequences-of-preventable-adverse-drug-events-protocol-for-an-overview-of-reviews
#1
Brian Hutton, Salmaan Kanji, Erika McDonald, Fatemeh Yazdi, Dianna Wolfe, Kednapa Thavorn, Sally Pepper, Laurie Chapman, Becky Skidmore, David Moher
BACKGROUND: Medication errors represent a noteworthy source of harm to patients. In recent years, several systematic reviews have assessed the frequency and causes of these events, as well as other factors such as commonly associated drugs, their incidence in different specialties, and their consequences to patients. Despite this past literature, there remains a need to study discrepancies between these reviews and establish the current state of the evidence. The planned review will bring together, compare, and contract existing evidence related to the occurrence of medication errors in acute and continuing/long-term care settings...
December 5, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27894665/modulatory-effects-of-curcumin-on-apoptosis-and-cytotoxicity-related-molecules-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#2
Asadollah Mohammadi, Bahare Fazeli, Marzieh Taheri, Amirhossein Sahebkar, Zohreh Poursina, Vida Vakili, Shadi Zamanian Yazdi, Zahra Keramati, Reza Boostani, Ian Hampson, Houshang Rafatpanah
Apoptosis is a universal cellular defense mechanism against viral infection. Curcumin, an anti-inflammatory phytochemical, induces apoptosis through mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. Here, we investigated the impact of supplementation with curcumin on the expression of a panel of apoptosis- and cytotoxicity-related genes in patients suffering from HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive demyelinating neuroinflammatory disease caused by HTLV-1 infection...
November 25, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27888139/an-improved-agar-medium-for-growth-of-geobacillus-thermoglucosidarius-strains
#3
M Javed, N Baghaei-Yazdi, W Qin, S Amartey
Geobacillus species have potential applications in many biotechnological processes. They are fastidious in their vitamin and amino acid requirements. A new semi-defined agar medium (SDM) was developed which gave consistently high viable cell counts of various G. thermoglucosidasius strains (5×10(8)-6×10(8)cfu/ml) under aerobic conditions at 70°C.
November 22, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27867054/thiolated-methylated-dimethylaminobenzyl-chitosan-a-novel-chitosan-derivative-as-a-potential-delivery-vehicle
#4
Shirin Hakimi, Elaheh Mortazavian, Zohreh Mohammadi, Fatemeh Yazdi Samadi, Hamidreza Samadikhah, Sadegh Taheritarigh, Niyousha Rafiee Tehrani, Morteza Rafiee-Tehrani
Chitosan is a natural mucoadhesive, biodegradable, biocompatible and nontoxic polymer which has been used in pharmaceutical industry for a lot of purposes such as dissolution enhancing, absorption enhancing, sustained releasing and protein, gene or drug delivery. Two major disadvantages of chitosan are poor solubility in physiological pH and low efficiency for protein and gene delivery. In this study thiolated methylated N-(4-N,N-dimethylaminobenzyl) chitosan was prepared for the first time in order to improve the solubility and delivery properties of chitosan...
November 17, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27865780/rasins-genetically-encoded-intrabodies-of-activated-ras-proteins
#5
Mehmet Cetin, William E Evenson, Garret G Gross, Farzad Jalali-Yazdi, Daniel Krieger, Don Arnold, Terry T Takahashi, Richard W Roberts
K- and H-Ras are the most commonly mutated genes in human tumors and are critical for conferring and maintaining the oncogenic phenotype in tumors with poor prognoses. Here, we design genetically encoded antibody-like ligands (intrabodies) that recognize active, GTP-bound K- and H-Ras. These ligands, which use the 10th domain of human fibronectin as their scaffold, are stable inside cells and when fused with a fluorescent protein label constitutively active G12V mutant H-Ras. Primary selection of ligands against Ras with mRNA display resulted in an intrabody (termed RasIn1) that binds with a KD of 2...
November 16, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27863332/combined-effect-of-aerobic-interval-training-and-selenium-nanoparticles-on-expression-of-il-15-and-il-10-tnf-%C3%AE-ratio-in-skeletal-muscle-of-4t1-breast-cancer-mice-with-cachexia
#6
M Molanouri Shamsi, S Chekachak, S Soudi, L S Quinn, K Rangbar, J Chenari, M H Yazdi, M Mahdavi
Cancer cachexia is characterized by inflammation, loss of skeletal muscle and adipose tissue mass, and functional impairment. Oxidative stress and inflammation are believed to regulate pathways controlling skeletal muscle wasting. The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, selenium nanoparticle supplementation, on expression of IL-15 and inflammatory cytokines in 4T1 breast cancer-bearing mice with cachexia. Selenium nanoparticle supplementation accelerated cachexia symptoms in tumor-bearing mice, while exercise training prevented muscle wasting in tumor-bearing mice...
November 15, 2016: Cytokine
https://www.readbyqxmd.com/read/27846562/dynamic-creation-and-evolution-of-gradient-nanostructure-in-single-crystal-metallic-microcubes
#7
Ramathasan Thevamaran, Olawale Lawal, Sadegh Yazdi, Seog-Jin Jeon, Jae-Hwang Lee, Edwin L Thomas
We demonstrate the dynamic creation and subsequent static evolution of extreme gradient nanograined structures in initially near-defect-free single-crystal silver microcubes. Extreme nanostructural transformations are imposed by high strain rates, strain gradients, and recrystallization in high-velocity impacts of the microcubes against an impenetrable substrate. We synthesized the silver microcubes in a bottom-up seed-growth process and use an advanced laser-induced projectile impact testing apparatus to selectively launch them at supersonic velocities (~400 meters per second)...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27830081/inhibitory-effect-of-lactobacillus-plantarum-and-lb-fermentum-isolated-from-the-faeces-of-healthy-infants-against-nonfermentative-bacteria-causing-nosocomial-infections
#8
M M Soltan Dallal, A Davoodabadi, M Abdi, M Hajiabdolbaghi, M K Sharifi Yazdi, M Douraghi, S M Tabatabaei Bafghi
Nosocomial infection constitutes a major public health problem worldwide. Increasing antibiotic resistance of pathogens associated with nosocomial infections has also become a major therapeutic challenge for physicians. Thus, development of alternative treatment protocols, such as the use of probiotics, matters. The aim of this research was to determine the antagonistic properties of Lactobacillus plantarum and Lb. fermentum isolated from the faeces of healthy infants against nonfermentative bacteria causing nosocomial infections...
January 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/27826538/clinical-evaluation-of-percutaneous-caudal-epidural-adhesiolysis-with-the-racz-technique-for-low-back-pain-due-to-contained-disc-herniation
#9
Arman Taheri, Ali Reza Khajenasiri, Nader Ali Nazemian Yazdi, Saeid Safari, Javad Sadeghi, Maryam Hatami
OBJECTIVES: The authors evaluated the effectiveness of percutaneous epidural adhesiolysis (PEA) in patients with low back pain due to contained disc herniation. PATIENTS AND METHODS: Twenty patients with low back pain due to contained disc herniation underwent PEA treatment with the Racz technique. The patients were evaluated for pain score, medication intake, significant pain relief, and complications. RESULTS: At three days, one month, three months, and six months after PEA compared to pre-PEA evaluations, the pain scores and medication intake were significantly decreased...
June 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27816679/optimization-of-the-production-conditions-of-the-lipase-produced-by-bacillus-cereus-from-rice-flour-through-plackett-burman-design-pbd-and-response-surface-methodology-rsm
#10
Alireza Vasiee, Behrooz Alizadeh Behbahani, Farideh Tabatabaei Yazdi, Samira Moradi
In this study, the screening of lipase positive bacteria from rice flour was carried out by Rhodamin B agar plate method. Bacillus cereus was identified by 16S rDNA method. Screening of the appropriate variables and optimization of the lipase production was performed using Plackett-Burman design (PBD) and response surface methodology (RSM). Among the isolated bacteria, an aerobic Bacillus cereus strain was recognized as the best lipase-producing bacteria (177.3 ± 20 U/ml). Given the results, the optimal enzyme production conditions were achieved with coriander seed extract (CSE)/yeast extract ratio of 16...
November 2, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27815782/preliminary-source-tracking-of-male-specific-f-rna-coliphage-on-lettuce-as-a-surrogate-of-enteric-viruses-using-reverse-transcription-pcr
#11
Mojgan Yazdi, Masoud Yavarmanesh, Masumeh Bahreini, Mohebbat Mohebbi
The aim of this research was to preliminary track fecal source male-specific F(+)RNA coliphages including human and animals in lettuce. At first, two published virus extraction procedures of ultracentrifugation and PEG precipitation were compared using DAL assay for determining the recovery efficiency in lettuce spiked artificially with three concentrations (10(2), 10(4), 10(6) pfu/100 ml) of MS2 coliphage. The results showed that PEG precipitation had the highest recovery in which the recovery efficiency at the spiked level of 10(6) pfu/100 ml was 16...
November 4, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27808431/adf-winter-school-an-exciting-concept-of-the-arbeitsgemeinschaft-dermatologische-forschung-to-connect-young-scientists-and-clinician-scientists-in-dermatology-at-the-top-of-germany
#12
Amir S Yazdi, Meltem Barlin, Katharina Böhm, Fabian Gendrisch, Saeedeh Ghorbanalipoor, Stefanie Häberle, Annamarie Hamel, Svea Hüning, Clemens Hüttner, Irina Iwanova, Theodora Kanaki, Susanne Kimeswenger, Nadine Lohmann, Saira Munir, Sukalp Muzumdar, Manuel Pedro Pereira, Patricia Peking, Kristin Plesser, Adriana Rendon, Maximilian Rentschler, Carolin Schlumprecht, Anna Smorodchenko, Martin Stock, Jessica Tillmanns, Ugur Uslu, Kamran Ghoreschi, Martin Glatz, Stephan Grabbe, Manfred Kunz, Ralf Ludwig, Karin Scharffetter-Kochanek, Karin Loser
No abstract text is available yet for this article.
November 3, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27797237/frequency-of-flt3-itd-d835-gene-mutations-in-acute-myelogenous-leukemia-a-report-from-northeastern-iran
#13
Abolghasem Allahyari, Masoud Sadeghi, Hossein Ayatollahi, Hamed Najjaran Yazdi, Mohammad Tavakol
BACKGROUND: FLT3 is mutated in about 1/3 of acute myelogenous leukemia (AML) patients. The aim of the present study was to report the prevalence of FLT3 mutations and comparison with prognostic factors in AML patients in the Northeastern of Iran. MATERIALS AND METHODS: This cross-sectional study concerned 100 AML cases diagnosed based on bone marrow aspiration and peripheral blood. DNA for every AML patient was extracted and underwent PCR with FLT3-ITD primers. RESULTS: The mean age at diagnosis was 28...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27796912/assessing-short-term-deterioration-in-maintenance-na%C3%A3-ve-patients-with-copd-receiving-umeclidinium-vilanterol-and-tiotropium-a-pooled-analysis-of-three-randomized-trials
#14
M Reza Maleki-Yazdi, Dave Singh, Antonio Anzueto, Lee Tombs, William A Fahy, Ian Naya
INTRODUCTION: Dual bronchodilator therapy is reserved as a second-line treatment in patients with chronic obstructive pulmonary disease (COPD) and provides benefits in lung function and health status versus monotherapy. The aim of this study was to determine whether early initiation of a dual bronchodilator versus monotherapy reduced the risk of deterioration in COPD. METHODS: This post hoc pooled analysis investigated the efficacy and safety of umeclidinium/vilanterol (UMEC/VI) 62...
October 28, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27792863/association-of-vitamin-d-status-with-semen-quality-and-reproductive-hormones-in-iranian-subfertile-men
#15
Sh Abbasihormozi, A Kouhkan, A R Alizadeh, A Shahverdi, M H Nasr-Esfahani, M A Sadighi Gilani, R Salman Yazdi, A Matinibehzad, Z Zolfaghari
Although vitamin D deficiency is one of the most common health problems throughout the world, including Iran, conflicting information exists on the potential association between serum vitamin D levels and semen quality. This study intended to evaluate the association between serum vitamin D [25(OH) D3] with semen quality and hormones in Iranian subfertile men. We also compared mean vitamin D and hormone levels in normospermic men with oligoasthenoteratozoospermia (OAT) men. This cross-sectional study was conducted on 278 men who were referred to Royan Infertility Clinic (Tehran, Iran) from March to September 2014...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27790074/effects-of-siemens-tt-d-carbon-fiber-table-top-on-beam-attenuation-and-build-up-region-of-6%C3%A2-mv-photon-beam
#16
Asma Sheykhoo, Sara Abdollahi, Mohammad Hadi Hadizadeh Yazdi, Mahdi Ghorbani, Mohammad Mohammadi
AIM: This study deals with Monte Carlo simulations of the effects which the 550 TXT carbon fiber couch can have on the relevant parameters of a 6 MV clinical photon beam in three field sizes. BACKGROUND: According to the reports issued by the International Commission on Radiation Units and Measurements (ICRU), the calculated dose across a high gradient distribution should be within 2% of the relative dose, or within 0.2 cm of the isodose curve position in the target volume...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27788610/implementation-of-design-of-experiments-approach-for-the-micronization-of-a-drug-with-a-high-brittle-ductile-transition-particle-diameter
#17
Ashkan K Yazdi, Hugh D C Smyth
OBJECTIVE: To optimize air-jet milling conditions of ibuprofen (IBU) using design of experiment (DoE) method, and to test the generalizability of the optimized conditions for the processing of another non-steroidal anti-inflammatory drug (NSAID). METHODS: Bulk IBU was micronized using an Aljet mill according to a circumscribed central composite (CCC) design with grinding and pushing nozzle pressures (GrindP, PushP) varying from 20 to 110 psi. Output variables included yield and particle diameters at the 50(th) and 90(th) percentile (D50, D90)...
October 28, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27783139/lack-of-effect-of-smoking-status-on-axitinib-pharmacokinetics-in-patients-with-non-small-cell-lung-cancer
#18
May Garrett, Timothy Taylor, Diane R Mould, Michael A Amantea, Ying Chen, Antonella Ingrosso, Yazdi K Pithavala
PURPOSE: Axitinib, a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptors 1-3, is approved for second-line treatment of advanced renal cell carcinoma. Axitinib is partially metabolized by cytochrome P450 1A2, which is induced by chronic heavy smoking. The effect of smoking on axitinib pharmacokinetics was evaluated in a non-small-cell lung cancer (NSCLC) patient population with a large number of active and ex-smokers. METHODS: Data were pooled from six clinical studies-serial pharmacokinetics from two healthy volunteer studies (n = 58) and sparse pharmacokinetics from four NSCLC studies (n = 152)-for a nonlinear mixed effects modeling (NONMEM v7...
October 25, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27782183/evaluating-the-transferability-of-15-european-derived-fasting-plasma-glucose-snps-in-mexican-children-and-adolescents
#19
Christine Langlois, Arkan Abadi, Jesus Peralta-Romero, Akram Alyass, Fernando Suarez, Jaime Gomez-Zamudio, Ana I Burguete-Garcia, Fereshteh T Yazdi, Miguel Cruz, David Meyre
Genome wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) that are associated with fasting plasma glucose (FPG) in adult European populations. The contribution of these SNPs to FPG in non-Europeans and children is unclear. We studied the association of 15 GWAS SNPs and a genotype score (GS) with FPG and 7 metabolic traits in 1,421 Mexican children and adolescents from Mexico City. Genotyping of the 15 SNPs was performed using TaqMan Open Array. We used multivariate linear regression models adjusted for age, sex, body mass index standard deviation score, and recruitment center...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774508/prevalence-of-osteoporosis-and-its-risk-factors-in-men-with-copd-in-qazvin
#20
Mahnaz Abbasi, Mohammadali Zohal, Banafsheh Atapour, Zohreh Yazdi
Introduction. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Proper diagnosis of osteoporosis as a systemic adverse effect of COPD is of significant importance. The present study aimed at evaluating the prevalence of osteoporosis and its risk factors in men suffering from COPD in Qazvin (2014). Methods. This descriptive-analytical study was conducted on 90 patients with COPD using random sampling. Anthropometric data and results from physical examination were collected...
2016: International Journal of Chronic Diseases
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