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https://www.readbyqxmd.com/read/29150651/comprehensive-functional-enrichment-analysis-of-male-infertility
#1
Seyed Morteza Razavi, Marjan Sabbaghian, Mahdi Jalili, Adeleh Divsalar, Olaf Wolkenhauer, Ali Salehzadeh-Yazdi
Spermatogenesis is a multifactorial process that forms differentiated sperm cells in a complex microenvironment. This process involves the genome, epigenome, transcriptome, and proteome to ensure the stability of the spermatogonia and supporting cells. The identification of signaling pathways linked to infertility has been hampered by the inherent complexity and multifactorial aspects of spermatogenesis. Systems biology is a promising approach to unveil underlying signaling pathways and genes and identify putative biomarkers...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29148915/the-frequency-of-mutations-in-quinolone-resistance-determining-regions-and-plasmid-mediated-quinolone-resistance-in-shigella-isolates-recovered-from-pediatric-patients-in-tehran-iran-an-overlooked-problem
#2
Sajad Yaghoubi, Reza Ranjbar, Mohammad Mehdi Soltan Dallal, Mohammad Hasan Shirazi, Mohammad Kazem Sharifi-Yazdi
Fluoroquinolone (FQ) resistance in clinical isolates of Shigella species has been increasing reported in recent years. This study was carried out to find the mutations within the quinolone resistance-determining regions (QRDRs) and the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among the clinical isolates of Shigella sp. in Tehran, Iran. A total of 50 Shigella isolates were collected from five teaching therapeutic centers in Tehran, Iran and analyzed for antibiotic susceptibility over a period of 20 months from July 2015 to January 2017...
November 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29134950/structural-magnetic-and-electronic-properties-of-pulsed-laser-deposition-grown-srfeo3-%C3%AE-thin-films-and-srfeo3-%C3%AE-la2-3ca1-3mno3-multilayers
#3
E Perret, K Sen, J Khmaladze, B P P Mallett, M Yazdi-Rizi, P Marsik, S Das, I Marozau, M A Uribe-Laverde, R de Andrés Prada, J Strempfer, M Döbeli, N Biškup, M Varela, Y-L Mathis, C Bernhard
We studied the structural, magnetic and electronic properties of [Formula: see text] (SFO) thin films and [Formula: see text]/[Formula: see text] [Formula: see text]MnO3 (LCMO) superlattices that have been grown with pulsed laser deposition (PLD) on [Formula: see text] [Formula: see text] [Formula: see text] [Formula: see text] [Formula: see text] (LSAT) substrates. X-ray reflectometry and scanning transmission electron microscopy (STEM) confirm the high structural quality of the films and flat and atomically sharp interfaces of the superlattices...
November 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29131306/comparative-effectiveness-and-safety-of-cognitive-enhancers-for-treating-alzheimer-s-disease-systematic-review-and-network-metaanalysis
#4
Andrea C Tricco, Huda M Ashoor, Charlene Soobiah, Patricia Rios, Areti Angeliki Veroniki, Jemila S Hamid, John D Ivory, Paul A Khan, Fatemeh Yazdi, Marco Ghassemi, Erik Blondal, Joanne M Ho, Carmen H Ng, Brenda Hemmelgarn, Sumit R Majumdar, Laure Perrier, Sharon E Straus
BACKGROUND/OBJECTIVES: To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD). DESIGN: Systematic review and Bayesian network metaanalysis (NMA). SETTING: MEDLINE, EMBASE, Cochrane Library, CINAHL, Ageline (inception-March 2016). PARTICIPANTS: Individuals with AD in randomized controlled trials (RCTs), quasi-RCTs, and nonrandomized studies. INTERVENTION: Any combination of donepezil, rivastigmine, galantamine, or memantine...
September 29, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29116809/thermoelectricity-enhanced-electrocatalysis
#5
Tiva Sharifi, Xiang Zhang, Gelu Costin, Sadegh Yazdi, Cristiano F Woellner, Yang Liu, Chandra Sekhar Tiwary, Pulickel Ajayan
We show that thermoelectric materials can function as electrocatalysts and use thermoelectric voltage generated to initiate and boost electrocatalytic reactions. The electrocatalytic activity is promoted by the use of nanostructured thermoelectric materials in a hydrogen evolution reaction (HER) by the thermoelectricity generated from induced temperature gradients. This phenomenon is demonstrated using two-dimensional layered thermoelectric materials Sb2Te3 and Bi0.5Sb1.5Te3 where a current density approaching ∼50 mA/cm(2) is produced at zero potential for Bi0...
November 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/29115019/cell-laden-composite-suture-threads-for-repairing-damaged-tendons
#6
Raquel Costa-Almeida, Rui M A Domingues, Afsoon Fallahi, Huseyin Avci, Iman K Yazdi, Mohsen Akbari, Rui L Reis, Ali Tamayol, Manuela E Gomes, Ali Khademhosseini
Tendons have limited regenerative capacity due to their low cellularity and hypovascular nature, which results in poor clinical outcomes of presently used therapies. As tendon injuries are often observed in active adults, it poses an increasing socio-economic burden on healthcare systems. Currently, suture threads are used during surgical repair to anchor the tissue graft or to connect injured ends. Here, we created composite suture threads coated with a layer of cell-laden hydrogel that can be used for bridging the injured tissue aiming at tendon regeneration...
November 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29113936/reproducible-research-practices-are-underused-in-systematic-reviews-of-biomedical-interventions
#7
Matthew J Page, Douglas G Altman, Larissa Shamseer, Joanne E McKenzie, Nadera Ahmadzai, Dianna Wolfe, Fatemeh Yazdi, Ferrán Catalá-López, Andrea C Tricco, David Moher
OBJECTIVES: To evaluate how often reproducible research practices, which allow others to recreate the findings of studies, given the original data, are used in systematic reviews (SRs) of biomedical research. STUDY DESIGN AND SETTING: We evaluated a random sample of SRs indexed in MEDLINE® during February 2014, which focused on a therapeutic intervention and reported at least one meta-analysis. Data on reproducible research practices in each SR were extracted using a 26-item form by one author, with a 20% random sample extracted in duplicate...
November 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29105397/the-impact-of-genetic-variation-and-gene-expression-level-of-the-follicle-stimulating-hormone-receptor-on-ovarian-reserve
#8
Zeinab Ghezelayagh, Mehdi Totonchi, Shabnam Zarei-Moradi, Ommolbanin Asadpour, Saman Maroufizadeh, Poopak Eftekhari-Yazdi, Hamid Gourabi, Anahita Mohseni-Meybodi
OBJECTIVES: Ovarian reserve is defined as the capacity of the ovary to provide fertile oocytes. Diminished ovarian reserve (DOR) is a disorder in which ovaries are prone to go through early menopause. Where this loss of function occurs before the age of 40, it results in the premature ovarian failure (POF) disease. Throughout folliculogenesis, the follicle-stimulating hormone receptor (FSHR) starts a signaling cascade in the granulosa cells where its inactivation leads to the arrest of follicle maturation and therefore adversely affects ovarian reserve...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29104596/deposition-of-crystalline-hydroxyapatite-nanoparticles-on-y-tzp-ceramic-a-potential-solution-to-enhance-bonding-characteristics-of-y-tzp-ceramics
#9
Abbas Azari, Sakineh Nikzad Jamnani, Arash Yazdani, Faezeh Atri, Vania Rasaie, Abbas Fazel Anvari Yazdi
Objectives: Many advantages have been attributed to dental zirconia ceramics in terms of mechanical and physical properties; however, the bonding ability of this material to dental structure and/or veneering ceramics has always been a matter of concern. On the other hand, hydroxyapatite (HA) shows excellent biocompatibility and good bonding ability to tooth structure, with mechanically unstable and brittle characteristics, that make it clinically unacceptable for use in high stress bearing areas...
March 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29102891/mechanism-of-tribofilm-formation-on-ti6al4v-oxygen-diffusion-layer-in-a-simulated-body-fluid
#10
R Yazdi, H M Ghasemi, M Abedini, C Wang, A Neville
An Oxygen Diffusion Layer (ODL) was generated on the surface of Ti6Al4V alloy by thermal oxidation treatment. In vitro tests for cytotoxicity were performed in the presence of Ti6Al4V and the ODL samples with the culture of G292 Cells using MTT assay. The results showed a similar cell viability in the presence of the both samples. Wear behaviour of Ti6Al4V and the ODL samples was investigated in a phosphate buffered saline solution under a normal load of 30N at a sliding velocity of 0.1m/s. The worn surface and subsurface of the samples were studied using SEM, STEM, TEM, XPS, AFM, nano-hardness and surface profilometry...
October 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29098140/mpgn-and-mixed-cryoglobulinemia-in-a-patient-with-hepatitis-c-new-treatment-implications-and-renal-outcomes
#11
Shannon B Palombo, Eric C Wendel, Laura R Kidd, Farshid Yazdi, Mihran V Naljayan
. INTRODUCTION: The association of hepatitis C virus (HCV), cryoglobulinemia, and membranoproliferative glomerulonephritis (MPGN) is well known. Treatment of underlying HCV infection has greatly improved in recent years with the introduction of direct-acting antivirals (DAA), which have demonstrated curative sustained viral response (SVR) rates for select viral genotypes with the added benefit of less drug side effects. However, a mainstay of newer DAAs is sofosbuvir, which is contraindicated in patients with severe renal impairment...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29093739/aggressive-adenoid-cystic-carcinoma-of-maxillary-sinus-in-a-43-year-old-male-rare-case-report-and-review-of-literature
#12
Koorosh Rahmani, Shokouh Taghipour Zahir, Mohammad Baghi Yazdi, Alireza Navabazam
Adenoid cystic carcinoma (ACC) is a rare malignant tumor, mostly involving the minor salivary glands. Herein, we present a case of ACC in a 43-year-old man with symptoms of dental abscess as the initial presentation of the tumor. In spiral computed tomography (CT) scan, soft tissue mass with the erosion of maxillary sinus wall on the right side of the alveolar ridge was evident. Histopathological examination of the excised tumor with immunohistochemical studies (C-kit, Vimentin, pan-cytokeratin, p53, p63, and ki67 positive reaction) confirmed grade 2 ACC in the maxillary sinus...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29090050/pattern-visual-evoked-potentials-in-dyslexic-children
#13
Javad Heravian Shandiz, Mohsen Heyrani, Davood Sobhani-Rad, Zeinab Salehinejad, Shirin Shojaei, Mohamad Javad Khoshsima, Abbas Azimi, Abbas Ali Yekta, Seyed Hosein Hoseini Yazdi
PURPOSE: This study aimed to compare pattern visual evoked potential (PVEP) components in dyslexic and normal children. METHODS: This cross-sectional analytic study recruited 72 children, including 36 dyslexic and 36 normal participants aged 8-12 years. Visual examinations included measurement of distance visual acuity, refraction, and PVEP components of amplitudes and latencies with two different check sizes of 15 and 60 minutes (min) of arc at two contrast levels of 25% and 100%...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29075666/a-drug-pocket-at-the-lipid-bilayer-potassium-channel-interface
#14
Nina E Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder
Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and electrophysiologically tested 125 derivatives, analogs, and related compounds to dehydroabietic acid. Functional data in combination with docking and molecular dynamics simulations mapped a binding site for small-molecule compounds at the interface between the lipid bilayer and the transmembrane segments S3 and S4 of the voltage-sensor domain...
October 2017: Science Advances
https://www.readbyqxmd.com/read/29072052/association-between-polymorphisms-of-ercc5-gene-and-susceptibility-to-gastric-cancer-a-systematic-review-and-meta-analysis
#15
Abolfazl Namazi, Mohammad Forat-Yazdi, Mohammad Ali Jafari, Elnaz Foroughi, Soudabeh Farahnak, Rezvan Nasiri, Masoud Zare-Shehneh, Hossein Neamatzadeh
Background: several epidemiological studies have suggested that polymorphisms of the Excision Repair Cross Complementing Group-5 (ERCC5) gene might be related to gastric cancer risk; however, the results have been inconsistent or controversial. Therefore, we have performed a systematic review and meta-analysis to clarify the association between the ERCC5 gene polymorphisms and gastric cancer risk. Materials and Methods: An electronic search was conducted of several databases, including PubMed, Web of Science, and Google Scholar for articles that describe the association between polymorphisms of the ERCC5 gene and susceptibility of gastric cancer...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29065772/the-impact-of-chlamydia-trachomatis-infection-on-sperm-parameters-and-male-fertility-a-comprehensive-study
#16
M Moazenchi, M Totonchi, R Salman Yazdi, K Hratian, M A Mohseni Meybodi, M Ahmadi Panah, M Chehrazi, A Mohseni Meybodi
Chlamydia trachomatis (CT), an obligate intracellular bacterium, requires living cells to replicate. Half of men infected with CT are asymptomatic. CT infection can persist for up to four years within couples and affect their fertility. Chlamydia infection in men acts as a reservoir for transmission to women and can cause urinary tract inflammation, sperm DNA damage, and acute epididymitis. Semen samples from 1080 subfertile patients with normal and abnormal spermograms were examined to detect the presence of CT...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29061968/comprehensive-assessment-of-the-safety-of-olodaterol-5%C3%A2-%C3%A2%C2%B5g-in-the-respimat-%C3%A2-device-for-maintenance-treatment-of-copd-comparison-with-the-long-acting-%C3%AE-2-agonist-formoterol
#17
Andrea Koch, Henrik Watz, M Reza Maleki-Yazdi, Ulrich Bothner, Kay Tetzlaff, Florian Voß, Lorcan McGarvey
This analysis provides a comprehensive clinical assessment of the long-term safety of the licensed dose of olodaterol (5 µg once daily [QD] via Respimat(®) inhaler) in patients with chronic obstructive pulmonary disease by exploring the occurrence of acknowledged side effects of long-acting β2-agonists as well as those included in the olodaterol and formoterol labels. We analysed pooled data from two replicate, double-blind studies of olodaterol (5 µg QD via Respimat(®)) compared to formoterol (12 µg twice daily [BID]) or placebo over 48 weeks (1222...
October 23, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29055478/predicting-falls-among-patients-with-multiple-sclerosis-comparison-of-patient-reported-outcomes-and-performance-based-measures-of-lower-extremity-functions
#18
Shirin Tajali, Mohammad-Jafar Shaterzadeh-Yazdi, Hossein Negahban, Jaap H van Dieën, Mohammad Mehravar, Nastaran Majdinasab, Amal Saki-Malehi, Razie Mofateh
BACKGROUND: Accurate fall screening tools are needed to identify those multiple sclerosis (MS) patients at high risk of falling. The present study aimed at determining the validity of a series of performance-based measures (PBMs) of lower extremity functions and patient-reported outcomes (PROs) in predicting falls in a sample of MS patients (n = 84), who were ambulatory independent. METHODS: Patients were assessed using the following PBMs: timed up and go (TUG), timed 25-foot walk (T25FW), cognitive T25FW, 2-min walk (2MW), and cognitive 2MW...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055467/diagnostic-evaluation-of-dysphagia-in-multiple-sclerosis-patients-using-a-persian-version-of-dymus-questionnaire
#19
Sahar Danesh Pajouh, Negin Moradi, Mohammad Jafar Shaterzadeh Yazdi, Seyed Mahmoud Latifi, Mohammad Mehravar, Nastaran Majdinasab, Ali Reza Olapour, Majid Soltani, Fatemeh Khanchezar
BACKGROUND: Multiple sclerosis is a chronic neurological disease that may cause swallowing disorders. Dysphagia is a common problem, which patients with different levels of disability may encounter, but it is usually underestimated; therefore, effective assessments need to be performed before any serious complications. The aim of this study was to identify the frequency and characteristics of dysphagia in multiple sclerosis patients of Khuzestan MS society, using a Persian version of Dysphagia in Multiple Sclerosis (DYMUS) questionnaire...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29047224/ral-signaling-pathway-in-health-and-cancer
#20
REVIEW
Adel Rezaei Moghadam, Elham Patrad, Elham Tafsiri, Warner Peng, Benjamin Fangman, Timothy J Pluard, Anthony Accurso, Michael Salacz, Kushal Shah, Brandon Ricke, Danse Bi, Kyle Kimura, Leland Graves, Marzieh Khajoie Najad, Roya Dolatkhah, Zohreh Sanaat, Mina Yazdi, Naeimeh Tavakolinia, Mohammad Mazani, Mojtaba Amani, Saeid Ghavami, Robyn Gartell, Colleen Reilly, Zaid Naima, Tuba Esfandyari, Faris Farassati
The Ral (Ras-Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown that the activation of RalA in cancer stem cells is higher in comparison with differentiated cancer cells...
October 18, 2017: Cancer Medicine
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