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Hao Yang, Shan Liu, Huawei Cai, Lin Wan, Shengfu Li, Youping Li, Jingqiu Cheng, Xiaofeng Lu
The use of cell-penetrating peptides (CPPs) as drug carriers for targeted therapy is limited by the unrestricted cellular translocation of CPPs. The preferential induction of tumor cell death by penetratin (Antp)-directed peptides (PNC27 and PNC28), however, suggests that the CPP Antp may contribute to the preferential cytotoxicity of these peptides. Using PNC27 as a molecular model, we constructed three novel peptides (PT, PR9, and PD3) by replacing the leader peptide Antp with one of three distinct CPPs (TAT, R9, or DPV3), respectively...
August 13, 2010: Journal of Biological Chemistry
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