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https://www.readbyqxmd.com/read/28448958/evaluation-of-f8-tnf-%C3%AE-in-models-of-early-and-progressive-metastatic-osteosarcoma
#1
Bernhard Robl, Sander Martijn Botter, Aleksandar Boro, Daniela Meier, Dario Neri, Bruno Fuchs
The targeted delivery of tumor necrosis factor-α (TNF-α) with antibodies specific to splice isoforms of fibronectin [e.g., F8-TNF, specific to the extra-domain A (EDA) domain of fibronectin] has already shown efficacy against experimental sarcomas but has not yet been investigated in orthotopic sarcomas. Here, we investigated F8-TNF in a syngeneic K7 M2-derived orthotopic model of osteosarcoma as a treatment against pulmonary metastases, the most frequent cause of osteosarcoma-related death. Immunofluorescence on human osteosarcoma tissue confirmed the presence of EDA in primary tumors (PTs) as well as metastases...
April 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28448535/alpha-1-antitrypsin-supplementation-improves-alveolar-macrophages-efferocytosis-and-phagocytosis-following-cigarette-smoke-exposure
#2
Karina A Serban, Daniela N Petrusca, Andrew Mikosz, Christophe Poirier, Angelia D Lockett, Lauren Saint, Matthew J Justice, Homer L Twigg, Michael A Campos, Irina Petrache
Cigarette smoking (CS), the main risk factor for COPD (chronic obstructive pulmonary disease) in developed countries, decreases alveolar macrophages (AM) clearance of both apoptotic cells and bacterial pathogens. This global deficit of AM engulfment may explain why active smokers have worse outcomes of COPD exacerbations, episodes characterized by airway infection and inflammation that carry high morbidity and healthcare cost. When administered as intravenous supplementation, the acute phase-reactant alpha-1 antitrypsin (A1AT) reduces the severity of COPD exacerbations in A1AT deficient (AATD) individuals and of bacterial pneumonia in murine models, but the effect of A1AT on AM scavenging functions has not been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28448311/surgical-techniques-for-closure-of-a-scalp-defect-after-resection-of-skin-malignancy
#3
Maciej Rysz, Dariusz Grzelecki, Maciej Mazurek, Stanisław Starościak, Romuald Krajewski
BACKGROUND: Surgery for scalp malignancies is aimed at the complete resection and a good aesthetic outcome. The goal was to develop an algorithm for scalp reconstruction based on the authors' surgical experience. METHODS: This is a retrospective analysis of 123 procedures of scalp malignancies in 105 patients. Twenty eight procedures were for resection of squamous cell carcinoma, 54 for basal cell carcinoma, and 41 for suspected melanomas. RESULTS: Primary closure (27 procedures), local flap (LF; 19), split-thickness skin graft (SG; 64), rotated LF and SG (9), and free vascularized flaps (4) were used...
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28447762/inhibition-of-aldose-reductase-ameliorates-ethanol%C3%A2-induced-steatosis-in-hepg2-cells
#4
Longxin Qiu, Chengchao Cai, Xiangqian Zhao, Yan Fang, Weibiao Tang, Chang Guo
Aldose reductase (AR) expression is increased in liver tissue of patients with ethanol‑induced liver disease. However, the exact role of AR in the development of ethanol‑induced liver disease has yet to be elucidated. The present study aimed to determine the effect of an AR inhibitor on ethanol‑induced steatosis in HepG2 cells and to identify possible underlying molecular mechanisms. Steatosis was induced in HepG2 cells by stimulating cells with 100 mM absolute ethanol for 48 h. Oil Red O staining was used to detect the lipid droplet accumulation in cells...
March 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447740/calyptranthes-grandifolia-o-berg-myrtaceae-ethanolic-extract-inhibits-tnf-%C3%AE-gene-expression-and-cytokine-release-in%C3%A2-vitro
#5
Geórgia Muccillo Dexheimer, Luciana Knabben de Oliveira Becker Delving, Henrique Sulzbach de Oliveira, Vanderlei Biolchi, Márcia Inês Goettert, Adriane Pozzobon
Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticancer therapy. Several anti‑inflammatory agents isolated from natural products are becoming important chemopreventive and therapeutic agents for cancer. The present study aimed to investigate the expression of TNF‑α, nuclear factor‑κΒ (NF‑κΒ) and p38α mitogen-activated protein kinase (p38α) genes, associated with proliferation and inflammation in the Caco‑2 cell line treated with ethanolic and hexanic extracts of Calyptranthes grandifolia O...
March 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447721/clinical-significance-of-inflammatory-cytokine-and-chemokine-expression-in-hand-foot-and-mouth-disease
#6
Ping Shao, Xiaoxin Wu, Hongbo Li, Zhigang Wu, Zongxin Yang, Hangping Yao
The present study examined the relationship between cytokine and chemokine expression and the clinical presentation of hand, foot and mouth disease (HFMD), which is currently unclear. The present study involved 28 patients with mild HFMD, 44 patients with severe HFMD and 26 healthy children. Venous blood was tested for cytokine [interleukin (IL)‑4, IL‑12, IL‑18, tumor necrosis factor‑α (TNF‑α), interferon‑γ (IFN‑γ)] and chemokine expression [IL‑8, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein‑1 (MCP‑1) and IFN-γ-inducible protein‑10 (IP‑10)]...
March 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447667/tweak-blockade-decreases-atherosclerotic-lesion-size-and-progression-through-suppression-of-stat1-signaling-in-diabetic-mice
#7
Valvanera Fernández-Laso, Cristina Sastre, Nerea Méndez-Barbero, Jesús Egido, Jose L Martín-Ventura, Carmen Gómez-Guerrero, Luis M Blanco-Colio
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK/Tnfsf12) is a cytokine implicated in different steps associated with vascular remodeling. However, the role of TWEAK under hyperglycemic conditions is currently unknown. Using two different approaches, genetic deletion of Tnfsf12 and treatment with a TWEAK blocking mAb, we have analyzed the effect of TWEAK inhibition on atherosclerotic plaque progression and stability in streptozotocin-induced diabetic ApoE deficient mice. Genetic inactivation of Tnfsf12 reduced atherosclerosis extension and severity in diabetic ApoE deficient mice...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28447447/nuclear-targeting-gold-nanorods-for-extremely-low-nir-activated-photothermal-therapy
#8
Limin Pan, Jianan Liu, Jianlin Shi
Photo-related nanomedicine is of particular interest as an emerging paradigm toward precise cancer therapy, as demonstrated by the recent developments of photothermal therapy (PTT), an emerging technique employing light converting agents to burn cancerous cells by over-dosed optical energy-converted heat. However, most of the laser irradiations needed for effective PTT significantly exceed the maximal permissible power density in human skin, which is likely to damage surrounding normal tissues. Herein, we report a strategy of intranuclear PTT of cancer enabled by nuclear-targeted delivery of gold nanorods of ~ 10...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447368/optimization-of-aqueous-extraction-and-biological-activity-of-harpagophytum-procumbens-root-on-ex-vivo-rat-colon-inflammatory-model
#9
Marcello Locatelli, Claudio Ferrante, Simone Carradori, Daniela Secci, Lidia Leporini, Annalisa Chiavaroli, Sheila Leone, Lucia Recinella, Giustino Orlando, Sara Martinotti, Luigi Brunetti, Michele Vacca, Luigi Menghini
Harpagophytum procumbens has a long story of use for the treatment of inflammatory diseases. Considering both the antiinflammatory effects of H. procumbens in multiple tissues and the stability of harpagoside in artificial intestinal fluid, the aim of the present study was to explore the possible protective role of a microwave-assisted aqueous Harpagophytum extract (1-1000 μg/mL) on mouse myoblast C2C12 and human colorectal adenocarcinoma HCT116 cell lines, and isolated rat colon specimens challenged with lipopolysaccharide (LPS), a validated ex vivo model of acute ulcerative colitis...
April 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28446968/the-role-of-transforming-growth-factor-tgf-%C3%AE-in-the-infarcted-myocardium
#10
REVIEW
Nikolaos G Frangogiannis
The adult mammalian heart has negligible regenerative capacity. Following myocardial infarction, sudden necrosis of cardiomyocytes triggers an intense inflammatory reaction that clears the wound from dead cells and matrix debris, while activating a reparative program. A growing body of evidence suggests that members of the transforming growth factor (TGF)-β family critically regulate the inflammatory and reparative response following infarction. Although all three TGF-β isoforms (TGF-β1, -β2 and -β3) are markedly upregulated in the infarcted myocardium, information on isoform-specific actions is limited...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446778/tumor-necrosis-factor-prevents-candida-albicans-biofilm-formation
#11
Francisco Airton Castro Rocha, Anelise Maria Costa Vasconcelos Alves, Marcos Fábio Gadelha Rocha, Rossana de Aguiar Cordeiro, Raimunda Sâmia Nogueira Brilhante, Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Virgínia Cláudia Carneiro Girão, José Julio Costa Sidrim
Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may influence the development of microorganisms either by promoting their growth or displaying antimicrobial activity...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446720/il-8-promotes-inflammatory-mediators-and-stimulates-activation-of-p38-mapk-erk-nf-%C3%AE%C2%BAb-pathway-and-reduction-of-jnk-in-hnscc
#12
Leong-Perng Chan, Cheng Liu, Feng-Yu Chiang, Ling-Feng Wang, Ka-Wo Lee, Wan-Ting Chen, Po-Lin Kuo, Chia-Hua Liang
This investigation identifies interleukin 8 (IL-8) as the main inflammatory mediator in head and neck squamous cell carcinoma (HNSCC). The expressions of chemokines of IL-8, IL-1β and IL-6 and the cytokines of tumor necrosis factor-α (TNF-α) were higher in HNSCC patient tissues than in non-cancerous matched tissues (NCMT) whereas the expression of IL-10 was lower. IL-8 is most highly expressed in the tissues of patients with HNSCC. Treatment of HNSCC cells with IL-8 increased the secretion of IL-1β, IL-6 and TNF-α and reduced IL-10 expression; the increase in the expression of IL-1β was particularly considerable...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446541/nuclear-survivin-expression-correlates-with-endoglin-assessed-microvascularisation-in-laryngeal-carcinoma
#13
Gino Marioni, Giancarlo Ottaviano, Rosario Marchese-Ragona, Elena Fasanaro, Giulia Tealdo, Claudia Zanotti, Benedetto Randon, Luciano Giacomelli, Edoardo Stellini, Stella Blandamura
AIMS: Survivin-a member of the family of inhibitor of apoptosis proteins that control cell division, apoptosis and metastasis-is overexpressed in virtually all human cancers, including laryngeal squamous cell carcinoma (LSCC). Recent findings also correlate survivin expression with the regulation of angiogenesis. The novel main aim of this study was a preliminary investigation into the potential role of survivin expression in LSCC neoangiogenesis, as determined by endoglin-assessed microvascular density (MVD)...
April 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28446249/adipose-derived-mesenchymal-stem-cells-modulate-cd14-cd16-expression-on-monocytes-from-sepsis-patients-in-vitro-via-prostaglandin-e2
#14
Guanguan Qiu, Guoping Zheng, Menghua Ge, Lanfang Huang, Haijiang Tong, Ping Chen, Dengming Lai, Yaoqin Hu, Baoli Cheng, Qiang Shu, Jianguo Xu
BACKGROUND: Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. CD16(+) monocytes are proinflammatory and abundant in inflammatory conditions such as sepsis. The primary objective in this exploratory study was to determine the effects of adipose-derived MSCs (ASCs) on three subsets of monocytes from sepsis patients in vitro and to delineate the underlying mechanism. METHODS: This is a prospective cohort study of patients admitted to the medical intensive care unit (ICU) at an academic medical center...
April 26, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28446195/mature-leaf-concentrate-of-sri-lankan-wild-type-carica-papaya-linn-modulates-nonfunctional-and-functional-immune-responses-of-rats
#15
Chanika Dilumi Jayasinghe, Dinara S Gunasekera, Nuwan De Silva, Kithmini Kawya Mandakini Jayawardena, Preethi Vidya Udagama
BACKGROUND: The leaf concentrate of Carica papaya is a traditionally acclaimed immunomodulatory remedy against numerous diseases; nonetheless comprehensive scientific validation of this claim is limited. The present study thus investigated the immunomodulatory potential of Carica papaya mature leaf concentrate (MLCC) of the Sri Lankan wild type cultivar using nonfunctional and functional immunological assays. METHODS: Wistar rats (N = 6/ group) were orally gavaged with 3 doses (0...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28446156/conjunctival-granuloma-with-necrosis-associated-with-exposed-suture-in-upper-double-lid-masquerading-as-ocular-surface-squamous-neoplasia-a-case-report
#16
Yu Jeong Kim, Jaeyoung Kim, Hokyung Choung, Mee Kum Kim, Won Ryang Wee
BACKGROUND: This study reports two cases of conjunctival granuloma with necrosis caused by an exposed suture in the upper palpebral conjunctiva masquerading as ocular surface squamous neoplasia. CASE PRESENTATION: Two patients presented with chronic conjunctival ulcerative and granulomatous lesions on the superior bulbar conjunctiva that repeatedly recurred after the mass was removed. The pathologic findings revealed the absence of malignant cells and presence of many lymphocytes, plasma cells, and histiocytes...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28446126/cd44-silencing-decreases-the-expression-of-stem-cell-related-factors-induced-by-transforming-growth-factor-%C3%AE-1-and-tumor-necrosis-factor-%C3%AE-in-lung-cancer-preliminary-findings
#17
Fariz Nurwidya, Fumiyuki Takahashi, Motoyasu Kato, Hario Baskoro, Moulid Hidayat, Aditya Wirawan, Kazuhisa Takahashi
The mechanism underlying increased concentrations of cancer stem cells (CSCs)-associated factors in non-small cell lung cancer (NSCLC) cells treated with transforming growth factor β1 (TGFβ1) and tumor necrosis factor α (TNFα), is still not clear. The purpose of this study was to investigate the possible role of CD44 in the regulation of CSC-associated genes, by analyzing the effect of CD44 knockdown on the expression of CSC-associated genes. A549, a NSCLC cell line that expresses CD44 antigen, was treated with TGFβ1 and TNFα...
April 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28446013/the-in-vivo-effect-of-ytterbium-doped-fiber-laser-on-rat-buccal-mucosa-as-a-simulation-of-its-effect-on-the-urinary-tract-a-preclinical-histopathological-evaluation
#18
Songzhe Piao, Yue Wang, Young Ju Lee, Seungsoo Hong, Yoonchan Jeong, Seung-June Oh
PURPOSE: The aim of this study was to perform a histological analysis of the effect of a ytterbium-doped fiber (YDF) laser on oral buccal mucosa tissue in vivo to simulate its effect on the mucosa of the lower urinary tract. METHODS: A total of 90 8-week-old Sprague-Dawley rats were anesthetized with urethrane (1.2 g/kg intraperitoneally). A prespecified inner buccal mucosal site was irradiated with a YDF master-oscillator power amplifier (MOPA) system for 60 seconds, with output power settings of 0...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28445842/%C3%AE-eta-eudesmol-reduces-stem-cell-factor-induced-mast-cell-migration
#19
Sun-Young Nam, Hee-Yun Kim, Hyung-Min Kim, Hyun-Ja Jeong
Previously, we showed the inhibitory effects of β-eudesmol on mast cell-mediated allergic inflammatory responses. Stem cell factor (SCF) participates in allergic reactions through the differentiation and migration of mast cells. However, the effects of β-eudesmol on SCF-mediated allergic reactions are poorly understood. Herein, we showed that a treatment of rat peritoneal mast cells (RPMCs) with β-eudesmol markedly suppressed SCF-induced mast cell migration and morphological alterations in a concentration-dependent manner...
April 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28445531/antagomir-451-inhibits-oxygen-glucose-deprivation-ogd-induced-huvec-necrosis-via-activating-ampk-signaling
#20
Xi Yang, Xiao-Qing He, Guo-Dong Li, Yong-Qing Xu
Oxygen glucose deprivation (OGD) application in cultured human umbilical vein endothelial cells (HUVECs) mimics ischemic injuries. AntagomiR-451, the miroRNA-451 ("miR-451") inhibitor, could activate pro-survival AMP-activated protein kinase (AMPK) signaling. In the current study, we showed that forced-expression of antagomiR-451 depleted miRNA-451 and significantly attenuated OGD-induced necrosis of HUVECs. Activation of AMPK was required for antagomiR-451-mediated pro-survival actions. AMPK inhibition, by AMPKα shRNA or dominant negative mutation, almost completely abolishedantagomiR-451-mediated HUVEC protection again OGD...
2017: PloS One
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