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Hypoxic-ischemic encephalopathy

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https://www.readbyqxmd.com/read/28226873/using-hilbert-huang-transform-to-assess-eeg-slow-wave-activity-during-anesthesia-in-post-cardiac-arrest-patients
#1
Jukka Kortelainen, Eero Vayrynen, Usko Huuskonen, Jouko Laurila, Juha Koskenkari, Janne T Backman, Seppo Alahuhta, Tapio Seppanen, Tero Ala-Kokko, Jukka Kortelainen, Eero Vayrynen, Usko Huuskonen, Jouko Laurila, Juha Koskenkari, Janne T Backman, Seppo Alahuhta, Tapio Seppanen, Tero Ala-Kokko, Eero Vayrynen, Janne T Backman, Jukka Kortelainen, Tapio Seppanen, Jouko Laurila, Usko Huuskonen, Seppo Alahuhta, Tero Ala-Kokko, Juha Koskenkari
Hypoxic ischemic encephalopathy (HIE) is a severe consequence of cardiac arrest (CA) representing a substantial diagnostic challenge. We have recently designed a novel method for the assessment of HIE after CA. The method is based on estimating the severity of the brain injury by analyzing changes in the electroencephalogram (EEG) slow wave activity while the patient is exposed to an anesthetic drug propofol in a controlled manner. In this paper, Hilbert-Huang Transform (HHT) was used to analyze EEG slow wave activity during anesthesia in ten post-CA patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226660/identifying-stereotypic-evolving-micro-scale-seizures-sems-in-the-hypoxic-ischemic-eeg-of-the-pre-term-fetal-sheep-with-a-wavelet-type-ii-fuzzy-classifier
#2
Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Charles P Unsworth, Laura Bennet, Hamid Abbasi, Alistair J Gunn
Perinatal hypoxic-ischemic encephalopathy (HIE) around the time of birth due to lack of oxygen can lead to debilitating neurological conditions such as epilepsy and cerebral palsy. Experimental data have shown that brain injury evolves over time, but during the first 6-8 hours after HIE the brain has recovered oxidative metabolism in a latent phase, and brain injury is reversible. Treatments such as therapeutic cerebral hypothermia (brain cooling) are effective when started during the latent phase, and continued for several days...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226644/examining-the-effect-of-mgso4-on-sharp-wave-transient-activity-in-the-hypoxic-ischemic-fetal-sheep-model
#3
Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Laura Bennet, Hamid Abbasi, Alistair J Gunn, Meherzad J Lakadia, Charles P Unsworth
Hypoxic-ischemic encephalopathy (HIE) due to lack of oxygen is a debilitating disorder experienced by a significant number of preterm infants during birth. Studies show that the brain undergoes different phases of injury following hypoxic insult, but the first 6-8 hours (known as a latent phase) are the key to treatment efficacy. Cerebral hypothermia is one known treatment, and for it to be effective it must be started during the latent phase and continued for several days. In order to determine the effectiveness of treatment it is important to pinpoint the time of insult...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226400/population-pharmacokinetics-and-pharmacodynamic-target-attainment-of-ampicillin-in-neonates-with-hypoxemic-ischemic-encephalopathy-in-the-setting-of-controlled-hypothermia
#4
Jeffrey J Cies, Keri N Fugarolas, Wayne S Moore, Robert W Mason, Ogechukwu R Menkiti
STUDY OBJECTIVE: To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN: Prospective, open-label pharmacokinetic study. SETTING: 189-bed, freestanding children's tertiary care teaching hospital. PATIENTS: Thirteen neonates (three females, 10 males) with HIE encephalopathy receiving CH and ampicillin 100 mg/kg/dose intravenously every 8 hours who were admitted to the neonatal intensive care unit between May 2013 and June 2014...
February 22, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28225884/clinical-hypoxic-ischemic-encephalopathy-score-of-the-iberoamerican-society-of-neonatology-siben-a-new-proposal-for-diagnosis-and-management
#5
José Maria Rodriguez Perez, Sergio G Golombek, Augusto Sola
Hypoxic ischemic encephalopathy is a major complication of perinatal asphyxia, with high morbidity, mortality and neurologic sequelae as cerebral palsy, mostly in poor or developing countries. The difficulty in the diagnosis and management of newborns in these countries is astonishing, thus resulting in unreliable data on this pathology and bad outcomes regarding mortality and incidence of neurologic sequelae. The objective of this article is to present a new clinical diagnostic score to be started in the delivery room and to guide the therapeutic approach, in order to improve these results...
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28224092/language-and-cognitive-outcome-for-high-risk-neonates-at-the-age-of-2-3-years-experience-from-an-arab-country
#6
Tamer Abou-Elsaad, Hesham Abdel-Hady, Hemmat Baz, Doaa ElShabrawi
AIM: To investigate the effect of different neonatal risk factors on different language parameters as well as cognitive abilities among Arabic speaking Egyptian children at the age of two to three years of life and to find out which risk factor(s) had the greatest impact on language and cognitive abilities. METHODS: This retrospective cohort study was conducted on 103 children with age range of 2-3 years (median age 31 mo). They were 62 males and 41 females who were exposed to different high-risk factors in the perinatal period, with exclusion of metabolic disorders, sepsis/meningitis, congenital anomalies and chromosomal aberrations...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28222320/antioxidant-polymorphisms-do-not-influence-the-risk-of-epilepsy-or-its-drug-resistance-after-neonatal-hypoxic-ischemic-brain-injury
#7
Katarina Esih, Katja Goričar, Vita Dolžan, Zvonka Rener-Primec
PURPOSE: The aim of this study was to investigate if common functional antioxidant polymorphisms are associated with epilepsy after neonatal hypoxic-ischemic encephalopathy (HIE). The antioxidant enzymes manganese superoxide dismutase (SOD2), glutathione peroxidase 1 (GPX1) and catalase (CAT) represent the primary defence mechanism against reactive oxygen species (ROS). Evidence suggests that genetic variants in antioxidant enzymes could influence susceptibility to epilepsy, but to date the relationship between them remains unclear...
February 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28217152/value-of-electroencephalographic-monitoring-in-newborns-with-hypoxic-ischemic-encephalopathy-treated-with-hypothermia
#8
Hatem Hamed Elshorbagy, Ahmed A Azab, Naglaa M Kamal, Naglaa Fathy Barseem, Mohamed M Bassiouny, Mostafa A Elsayed, Tohamy H Elkhouly
BACKGROUND: The values of electroencephalography (EEG) in neonatal hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH) are still uncertain. AIMS: The aim of this study is to detect EEG background, the prevalence of seizures during cooling, and to determine different EEG patterns that can predict brain injury in magnetic resonance imaging (MRI). PATIENTS AND METHODS: Thirty-nine newborns with HIE were subjected to TH. Continuous monitoring by video-EEG was carried out throughout cooling and during rewarming...
October 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28211647/clinical-characteristics-predicting-abnormal-brain-magnetic-resonance-image-findings-in-hypoxic-ischemic-encephalopathy-infants
#9
Sook K Yum, Cheong-Jun Moon, Young-Ah Youn, In K Sung
BACKGROUND: The aim of this study was to elucidate the specific clinical characteristics associated with abnormal brain magnetic resonance image(MRI) findings in hypoxic ischemic encephalopathy(HIE) infants in order to discern how to predict poorer outcomes more accurately. METHODS: A retrospective data analysis of HIE infants admitted to the neonatal intensive care unit of a tertiary hospital was performed. Baseline perinatal information and physical and neurological findings were compared in HIE infants according to the presence of abnormal brain MRI findings...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28209514/plasma-metabolite-score-correlates-with-hypoxia-time-in-a-newly-born-piglet-model-for-asphyxia
#10
Julia Kuligowski, Rønnaug Solberg, Ángel Sánchez-Illana, Leonid Pankratov, Anna Parra-Llorca, Guillermo Quintás, Ola Didrik Saugstad, Máximo Vento
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia is a leading cause of mortality and acquired long-term neurologic co-morbidities in the neonate. The most successful intervention for the treatment of moderate to severe HIE is moderate whole body hypothermia initiated within 6h from birth. The objective and prompt identification of infants who are at risk of developing moderate to severe HIE in the critical first hours still remains a challenge. This work proposes a metabolite score calculated based on the relative intensities of three metabolites (choline, 6,8-dihydroxypurine and hypoxanthine) that showed maximum correlation with hypoxia time in a consolidated piglet model for neonatal hypoxia-ischemia...
February 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28206999/early-eeg-power-predicts-mri-injury-in-infants-with-hypoxic-ischemic-encephalopathy
#11
S V Jain, J M Zempel, P Srinivasakumar, M Wallendorf, A Mathur
OBJECTIVE: Early identification of infants with hypoxic-ischemic encephalopathy who have adverse outcomes despite neuroprotection with therapeutic hypothermia (TH) is urgently needed. Recent studies have found limited value of amplitude integrated EEG (aEEG) for predicting short-term outcomes in this population. Other quantitative electroencephalography (EEG) variables reflecting EEG amplitude, such as EEG power, could provide early stratification of a high-risk cohort in this population...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28198757/effect-of-temperature-on-heart-rate-variability-in-neonatal-icu-patients-with-hypoxic-ischemic-encephalopathy
#12
An N Massaro, Heather E Campbell, Marina Metzler, Tareq Al-Shargabi, Yunfei Wang, Adre du Plessis, Rathinaswamy B Govindan
OBJECTIVE: To determine whether measures of heart rate variability are related to changes in temperature during rewarming after therapeutic hypothermia for hypoxic-ischemic encephalopathy. DESIGN: Prospective observational study. SETTING: Level 4 neonatal ICU in a free-standing academic children's hospital. PATIENTS: Forty-four infants with moderate to severe hypoxic-ischemic encephalopathy treated with therapeutic hypothermia...
February 14, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28196356/therapeutic-hypothermia-provides-variable-protection-against-behavioral-deficits-after-neonatal-hypoxia-ischemia-a-potential-role-for-brain-derived-neurotrophic-factor
#13
Johana Diaz, Suleiman Abiola, Nancy Kim, Oliver Avaritt, Debra Flock, Jenny Yu, Frances J Northington, Raul Chavez-Valdez
BACKGROUND: Despite treatment with therapeutic hypothermia (TH), infants who survive hypoxic ischemic (HI) encephalopathy (HIE) have persistent neurological abnormalities at school age. Protection by TH against HI brain injury is variable in both humans and animal models. Our current preclinical model of hypoxia-ischemia (HI) and TH displays this variability of outcomes in neuropathological and neuroimaging end points with some sexual dimorphism. The detailed behavioral phenotype of this model is unknown...
February 15, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28190437/neurology-of-cardiopulmonary-resuscitation
#14
M Mulder, R G Geocadin
This chapter aims to provide an up-to-date review of the science and clinical practice pertaining to neurologic injury after successful cardiopulmonary resuscitation. The past two decades have seen a major shift in the science and practice of cardiopulmonary resuscitation, with a major emphasis on postresuscitation neurologic care. This chapter provides a nuanced and thoughtful historic and bench-to-bedside overview of the neurologic aspects of cardiopulmonary resuscitation. A particular emphasis is made on the anatomy and pathophysiology of hypoxic-ischemic encephalopathy, up-to-date management of survivors of cardiopulmonary resuscitation, and a careful discussion on neurologic outcome prediction...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28183504/a-6-month-old-infant-with-different-capnography-values-in-polysomnography
#15
Lourdes M DelRosso, Pacifico Palacay, Ngoc P Ly
A 6-month-old infant with a past medical history of hypoxic ischemic encephalopathy was referred for evaluation of snoring. She was born at 41 weeks' gestational age to a 25-year-old gravida 1, para 1 mother via vacuum-assisted delivery due to cardiac decelerations. The infant's Apgar scores were 1, 4, and 6 with nuchal cord and meconium at delivery. She was started on positive-pressure ventilation but eventually required intubation at approximately 40 minutes of life. Brain MRI showed abnormal areas of restricted diffusion, involving the corpus callosum, bilateral posterior limb of the internal capsules, and possible scattered areas of frontal and occipital lobe cortices...
February 2017: Chest
https://www.readbyqxmd.com/read/28182668/cross-sectional-study-of-mode-of-delivery-and-maternal-and-perinatal-outcomes-in-mainland-china
#16
Lei Hou, Susan Hellerstein, Allison Vitonis, Liying Zou, Yan Ruan, Xin Wang, Weiyuan Zhang
BACKGROUND: Cesarean delivery (CD) rates have risen globally with nearly 50% of the non-indicated CDs worldwide in China and Brazil. In China's One Child Policy era (1979-2015) most deliveries were women having their only child. Family size is a major determinant of the safety of medically non-indicated CD or CD on maternal request. The goal of this study is to document CD rates, indications, and analyze the relative safety of non-indicated CD compared to SVD and intrapartum CD. METHODS: Univariate and multivariate logistic regression analyses of the association between mode of delivery and short-term maternal and perinatal outcomes were performed on a cross-section of all deliveries at 39 hospitals in 14 provinces of China in 2011, presented as adjusted odds ratio (aOR), 99% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28180081/automatic-quantification-of-ischemic-injury-on-diffusion-weighted-mri-of-neonatal-hypoxic-ischemic-encephalopathy
#17
Keelin Murphy, Niek E van der Aa, Simona Negro, Floris Groenendaal, Linda S de Vries, Max A Viergever, Geraldine B Boylan, Manon J N L Benders, Ivana Išgum
A fully automatic method for detection and quantification of ischemic lesions in diffusion-weighted MR images of neonatal hypoxic ischemic encephalopathy (HIE) is presented. Ischemic lesions are manually segmented by two independent observers in 1.5 T data from 20 subjects and an automatic algorithm using a random forest classifier is developed and trained on the annotations of observer 1. The algorithm obtains a median sensitivity and specificity of 0.72 and 0.99 respectively. F1-scores are calculated per subject for algorithm performance (median = 0...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28166364/interrater-agreement-in-the-interpretation-of-neonatal-electroencephalography-in-hypoxic-ischemic-encephalopathy
#18
Courtney J Wusthoff, Joseph Sullivan, Hannah C Glass, Renée A Shellhaas, Nicholas S Abend, Taeun Chang, Tammy N Tsuchida
OBJECTIVE: Research using neonatal electroencephalography (EEG) has been limited by a lack of a standardized classification system and interpretation terminology. In 2013, the American Clinical Neurophysiology Society (ACNS) published a guideline for standardized terminology and categorization in the description of continuous EEG in neonates. We sought to assess interrater agreement for this neonatal EEG categorization system as applied by a group of pediatric neurophysiologists. METHODS: A total of 60 neonatal EEG studies were collected from three institutions...
February 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28164607/serum-levels-of-cardiac-troponin-i-in-asphyxiated-neonates-predict-mortality
#19
Wen-Jie Zhou, Fan Yu, Jing Shi, Hui Yang, Sheng-Jie Zou, Yong-Mei Jiang
BACKGROUND: Cardiac troponin I (cTnI) is a well-established marker for detecting myocardial ischemic damage in neonates with hypoxic-ischemic encephalopathy. However, the predictive value of cTnI in assessing mortality in neonatal asphyxia remains obscure. This retrospective study aims to analyze the relationship between cTnI levels in blood serum with gestational age, birth weight, gender, delivery type, electrocardiography, echocardiography, Apgar scores, length of hospital stay, and mortality in asphyxiated neonates...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164585/role-of-serum-level-of-neurometals-copper-zinc-and-magnesium-in-neonates-with-hypoxic-ischemic-encephalopathy
#20
Mostafa A El Foley, Hanan M Kamel, Samir M Mounir, Samuel N Habeb
BACKGROUND: Perinatal HIE is associated with high morbidity and mortality rates worldwide, despite the improvements in perinatal care. The aim of this study was to evaluate the role Cu, Zn, and Mg+2 neurometals in the development of neonatal hypoxic ischemic encephalopathy. METHODS: This study included two groups: group 1 (study group): Thirty full term, and diagnosed as having hypoxic ischemic encephalopathy. Group 2 (control group): Thirty full term healthy neonates...
September 1, 2016: Clinical Laboratory
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