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https://www.readbyqxmd.com/read/27911458/spondylodiscitis-a-rare-complication-following-percutaneous-nephrostomy
#1
Francesco Chiancone, Maurizio Fedelini, Clemente Meccariello, Luigi Pucci, Marco Fabiano, Paolo Fedelini
Spondylodiscitis is an inflammation of the intervertebral disc and the adjacent vertebral bodies. The spondylodiscitis can not only be a complication of medical interventions such as an operation near spinal column but also urogenital and vascular interventions and intravenous catheter use. A 71-year-old man was admitted to our emergency department with fever and severe abdominal pain. Antibiotic therapy had been performed with intravenous administration of 2 g of ceftriaxone and the patient underwent the placement of a percutaneous nephrostomy according to Seldinger technique...
November 28, 2016: Urologia
https://www.readbyqxmd.com/read/27905467/direct-identification-of-antibiotic-resistance-genes-on-single-plasmid-molecules-using-crispr-cas9-in-combination-with-optical-dna-mapping
#2
Vilhelm Müller, Fredrika Rajer, Karolin Frykholm, Lena K Nyberg, Saair Quaderi, Joachim Fritzsche, Erik Kristiansson, Tobias Ambjörnsson, Linus Sandegren, Fredrik Westerlund
Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in nanofluidic channels, which provides detailed information about the plasmids present in a bacterial isolate. In a single experiment, we obtain the number of different plasmids in the sample, the size of each plasmid, an optical barcode that can be used to identify and trace the plasmid of interest and information about which plasmid that carries a specific resistance gene...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904884/escherichia-coli-sequence-type-131-h30-is-the-main-driver-of-emerging-extended-spectrum-%C3%AE-lactamase-producing-e-coli-at-a-tertiary-care-center
#3
James R Johnson, Brian Johnston, Paul Thuras, Bryn Launer, Evgeni V Sokurenko, Loren G Miller
The H30 strain of Escherichia coli sequence type 131 (ST131-H30) is a recently emerged, globally disseminated lineage associated with fluoroquinolone resistance and, via its H30Rx subclone, the CTX-M-15 extended-spectrum beta-lactamase (ESBL). Here, we studied the clonal background and resistance characteristics of 109 consecutive recent E. coli clinical isolates (2015) and 41 historical ESBL-producing E. coli blood isolates (2004 to 2011) from a public tertiary care center in California with a rising prevalence of ESBL-producing E...
November 2016: MSphere
https://www.readbyqxmd.com/read/27903600/improved-accuracy-of-cefepime-susceptibility-testing-for-esbl-producing-enterobacteriaceae-using-an-on-demand-digital-dispensing-method
#4
Kenneth P Smith, Thea Brennan-Krohn, Susan Weir, James E Kirby
Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae generally cannot be treated with penicillins and cephalosporins. However, some later generation cephalosporins, including cefepime, are poorly hydrolyzed by specific ESBL enzymes, and certain strains demonstrate in vitro susceptibility to these agents, potentially affording additional treatment opportunities. Moreover, the ability to adjust both dose and dosing interval of β-lactam agents allows treatment of strains with elevated minimal inhibitory concentrations (MICs) formerly classified in the intermediate range...
November 30, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27902433/escherichia-coli-clonal-group-a-cga-among-uropathogenic-infections-in-mexico-city
#5
Angel Manjarrez-Hernandez, José Molina-López, Sandra Gavilanes-Parra, Rigoberto Hernandez-Castro
Escherichia coli clonal group A (CGA) causes urinary tract and other extraintestinal infections in humans. CGA is an important cause of trimethoprim/sulfamethoxazole (SXT)-resistance in extraintestinal pathogens. We examined the extent to which resistance in this area is related to CGA dissemination of E. coli from urinary tract infections (UTIs) in Mexico City. The virulence backgrounds of the isolates were also characterized. In this study, the frequency of resistance to SXT used for UTI treatment was high (56-65%) and CGA isolates accounted for 9 of the 78 SXT-resistant isolates (11...
November 7, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902398/clonal-spread-and-accumulation-of-beta-lactams-resistance-determinants-in-enterobacter-aerogenes-and-enterobacter-cloacae-complex-isolates-from-infection-and-colonization-in-patients-at-a-public-hospital-in-recife-pernambuco-brazil
#6
Adriane Borges Cabral, Maria Amélia Vieira Maciel, Josineide Ferreira Barros, Marcelo Maranhão Antunes, Célia Maria Machado Barbosa de Castro, Ana Catarina Souza Lopes
Enterobacter aerogenes and Enterobacter cloacae complex are the species of this genus most involved in healthcare-associated infections (HAIs), that are ESBL and carbapenemase producers. This study has characterized phenotypically and genotypically 51 isolates of E. aerogenes and E. cloacae complex as originated from infection or colonization in patients admitted to public hospital in Recife, Pernambuco, Brazil, by antimicrobial susceptibility profile, analysis of β-lactamase genes (blaTEM, blaSHV, blaCTX-M, blaKPC, blaVIM, blaIMP and blaSPM), PCR and DNA sequencing, plasmid profile and ERIC-PCR...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902381/detection-of-escherichia-coli-st131-complex-st705-and-klebsiella-pneumoniae-st15-among-fecal-carriage-of-extended-spectrum-betalactamase-and-carbapenemase-producing-enterobacteriaceae
#7
Esther Rios, Maria Carmen López, Iciar Rodríguez-Avial, Esther Culebras, Juan Jose Picazo
The objective of the present study was to evaluate the prevalence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and carbapenemases-producing Enterobacteriaceae (CPE) in non-selected hospitalized and non-hospitalized patients from the same geographic area of Madrid. Among the 501 patients enrolled, 43 (8.6%) carried ESBL-E and 8 (1.6%) patients exhibited CPE. The main intestinal colonizer among ESBL-E was CTX-M-producing Escherichia coli isolates in both settings (community and hospital)...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27899921/high-prevalence-of-%C3%AE-lactamase-and-plasmid-mediated-quinolone-resistance-genes-in-extended-spectrum-cephalosporin-resistant-escherichia-coli-from-dogs-in-shaanxi-china
#8
Xiaoqiang Liu, Haixia Liu, Yinqian Li, Caiju Hao
Objective: The aim of this study was to investigate the occurrence and molecular characterization of extended-spectrum β-lactamases (ESBL), plasmid-mediated AmpC β-lactamase (pAmpC) and carbapenemases as well as plasmid-mediated quinolone-resistant (PMQR) among extended-spectrum cephalosporin-resistant (ESC-R) Escherichia coli from dogs in Shaanxi province in China. Methods: A total of 40 ESC-R Escherichia coli selected from 165 Extraintestinal pathogenic E. coli (ExPEC) isolated from dogs were screened and characterized for the genes encoding for the ESBLs, pAmpC, carbapenemases and PMQR genes by PCR and sequencing...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27898030/assessment-of-the-activity-of-tigecycline-against-gram-positive-and-gram-negative-organisms-collected-from-italy-between-2012-and-2014-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t
#9
Stefania Stefani, Michael J Dowzicky
As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T) we report the in vitro activity of tigecycline and its comparators against Gram-negative and Gram-positive organisms collected from Italian centers between 2012 and 2014. Minimum inhibitory concentrations were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute, and antimicrobial resistance was determined using the European Committee on Antimicrobial Susceptibility Testing interpretive criteria...
November 26, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27895637/high-prevalence-of-esbl-producing-klebsiella-pneumoniae-causing-community-onset-infections-in-china
#10
Jing Zhang, Kai Zhou, Beiwen Zheng, Lina Zhao, Ping Shen, Jinru Ji, Zeqing Wei, Lanjuan Li, Jianying Zhou, Yonghong Xiao
The aim of this work was to investigate the epidemiological and genetic characteristics of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) causing community-onset infections. K. pneumoniae isolates were collected from 31 Chinese secondary hospitals between August 2010 and 2011. Genes encoding ESBL and AmpC beta-lactamases were detected by PCR. The isolates were assigned to sequence types (STs) using multi-locus sequence typing (MLST). Eleven ESBL-Kp strains were selected for whole-genome sequencing (WGS) for investigating the genetic environment and plasmids encoding ESBL genes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27894763/extended-spectrum-beta-lactamase-esbl-producing-bacteria-urinary-tract-infections-and-complex-pediatric-urology
#11
Ruth Wragg, Anna Harris, Mitul Patel, Andrew Robb, Harish Chandran, Liam McCarthy
AIM OF THE STUDY: Extended spectrum beta lactamase (ESBL) producing bacteria are resistant to most beta-lactam antibiotics including third-generation cephalosporins, quinolones and aminoglycosides. This resistance is plasmid-borne and can spread between species. Management of ESBL is challenging in children with recurrent urinary tract infections (UTIs) and complex urological abnormalities. We aim to quantify the risk in children and specifically in urological patients. METHODS: Retrospective review of a microbiology database (April 2014 to November 2015)...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27892858/longitudinal-study-of-ctx-m-esbl-producing-e-coli-strains-on-a-uk-dairy-farm
#12
R A Horton, D Duncan, L P Randall, S Chappell, L A Brunton, R Warner, N G Coldham, C J Teale
The aim of this study was to investigate the bacterial strains and farm environment that may contribute to the persistence of ESBL-producing E. coli on a single UK dairy farm. A longitudinal study was conducted comprising 6 visits, between August and October 2010, followed by a further visit at approximately 69weeks after the initial visit. Faecal and environmental samples were collected from different parts of the farm. The persistence and extent of faecal shedding of ESBL E. coli by individual calves was also determined...
September 30, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27891664/healthcare-costs-doubled-when-children-had-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-bacteria
#13
Oona Nieminen, Matti Korppi, Merja Helminen
AIM: The impact of the emergence of antimicrobial resistant organisms has rarely been studied in children, including the healthcare costs of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria. We evaluated the effect of ESBL on UTI healthcare costs and risk factors for paediatric UTIs. METHODS: This retrospective case-control study covered 2005-2014 and focused on children below 16 years of age treated in a University hospital: 22 children with UTIs caused by ESBL-producing bacteria and 56 ESBL-negative UTI controls...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27890813/international-travel-is-a-risk-factor-for-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-acquisition-in-children-a-single-center-case-case-control-study-in-an-urban-u-s-hospital
#14
Jonathan P Strysko, Vidya Mony, Jeremiah Cleveland, Hanna Siddiqui, Peter Homel, Christina Gagliardo
BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL) infections are increasing in both adults and children. The aim of this study was to describe the epidemiology of children with ESBL in an urban and ethnically-diverse population, to determine what proportion of these infections were community-onset, and to identify risk factors predisposing children to ESBL acquisition. METHODS: A case-case-control study of children aged 0-18 years was conducted from 2012-2014...
November 24, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27890442/predominance-of-healthcare-associated-cases-among-episodes-of-community-onset-bacteraemia-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#15
Jean-Ralph Zahar, Philippe Lesprit, Stephane Ruckly, Aurelia Eden, Hitoto Hikombo, Louis Bernard, Stephan Harbarth, Jean-François Timsit, Christian Brun-Buisson
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) are endemic pathogens worldwide. Infection with ESBL-PE may be associated with inadequate antibiotic therapy and a poor outcome. However, risk factors for ESBL-PE community-acquired infections are ill-defined. An observational multicentre study was performed in 50 hospitals to identify the prevalence of and risk factors for community-acquired ESBL-PE bacteraemia. All patients presenting with community-onset Enterobacteriaceae bacteraemia were recorded over a 2-month period (between June and November 2013)...
November 16, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27890366/in%C3%A2-vitro-biofilm-formation-in-esbl-producing-escherichia-coli-isolates-from-cage-birds
#16
Ebru Sebnem Yılmaz, Nur Ceyhan Güvensen
OBJECTIVE: To determine biofilm and hydrophobicity formation ratios in extended spectrum beta lactamases (ESBL) synthesizing Escherichia coli isolates which were isolated from feces samples of 150 cage bird species randomly taken from pet shops in Hatay province, Turkey. METHODS: In vitro biofilm production of 4 ESBL positive isolates were performed by Congo Red Agar (CRA), Standard Tube (ST) and Microtitre Plate (MP) methods while their hydrophobicity were examined by bacterial adhesion to hydrocarbon (BATH) test...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27889879/plasmid-mediated-quinolone-resistance-in-enterobacteriaceae-a-systematic-review-with-a-focus-on-mediterranean-countries
#17
REVIEW
B Yanat, J-M Rodríguez-Martínez, A Touati
Quinolones are a family of synthetic broad-spectrum antimicrobial drugs. These molecules have been widely prescribed to treat various infectious diseases and have been classified into several generations based on their spectrum of activity. Quinolones inhibit bacterial DNA synthesis by interfering with the action of DNA gyrase and topoisomerase IV. Mutations in the genes encoding these targets are the most common mechanisms of high-level fluoroquinolone resistance. Moreover, three mechanisms for plasmid-mediated quinolone resistance (PMQR) have been discovered since 1998 and include Qnr proteins, the aminoglycoside acetyltransferase AAC(6')-Ib-cr, and plasmid-mediated efflux pumps QepA and OqxAB...
November 26, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27889252/peripartum-maternal-transmission-of-extended-spectrum-%C3%AE-lactamase-organism-to-newborn-infants
#18
Avi Peretz, Alina Skuratovsky, Efrat Khabra, Amos Adler, Pastukh Nina, Shay Barak, Yuri Perlitz, Moshe Ben-Ami, Amir Kushnir
The aim of this study was to determine whether the route of extended-spectrum β-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed...
November 12, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27887765/activity-of-ceftazidime-avibactam-against-multidrug-resistance-enterobacteriaceae-expressing-combined-mechanisms-of-resistance
#19
Inmaculada López-Hernández, Noemí Alonso, Marta Fernández-Martínez, Laura Zamorano, Alba Rivera, Antonio Oliver, M Carmen Conejo, Luis Martínez-Martínez, Ferrán Navarro, Alvaro Pascual
INTRODUCTION: Antimicrobial resistance in Enterobacteriaceae is increasing worldwide and is making treating infections caused by multidrug-resistant Enterobacteriaceae a challenge. The use of β-lactam agents is compromised by microorganisms harboring extended-spectrum β-lactamases (ESBLs) and other mechanisms of resistance. Avibactam is a non β-lactam agent that inhibits clinically relevant β-lactamases, such as ESBL and AmpC. The ceftazidime-avibactam combination (CAZ-AVI) was recently approved for use in certain complicated infections, and may provide a therapeutic alternative for infections caused by these microorganisms...
November 22, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27885293/prevalence-of-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolated-from-urinary-tract-infected-patients
#20
P Chaudhary, D Bhandari, K Thapa, P Thapa, D Shrestha, H K Chaudhary, A Shrestha, H Parajuli, B P Gupta
BACKGROUND: Klebsiella pneumoniae, one of the bacterial agents associated with urinary tract infection has been often implicated as a major extended spectrum beta-lactamase (ESBL) producer in last few decades. This study was designed to assess the prevalence of ESBL producing Klebsiella pneumoniae in urinary isolates at a tertiary care hospital in Kathmandu, Nepal, from July to December 2014. METHODS: One thousand nine hundred eighty six mid-stream urine specimens were collected aseptically from the clinically suspected patients of urinary tract infections attending Capital Hospital and Research Center, Kathmandu...
May 2016: Journal of Nepal Health Research Council
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