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https://www.readbyqxmd.com/read/29351704/safety-of-cold-snare-polypectomy-for-duodenal-adenomas-in-familial-adenomatous-polyposis-a-prospective-exploratory-study
#1
Kenta Hamada, Yoji Takeuchi, Hideki Ishikawa, Yasumasa Ezoe, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Minoru Kato, Yusuke Tonai, Satoki Shichijo, Yasushi Yamasaki, Noriko Matsuura, Hiroko Nakahira, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Koji Higashino, Noriya Uedo, Ryu Ishihara, Hiroyuki Okada, Hiroyasu Iishi
BACKGROUND:  Cold snare polypectomy (CSP) to remove multiple duodenal adenomas (MDAs) in patients with familial adenomatous polyposis (FAP) could be an effective and less invasive method than more extensive surgery. The aim of the present study was to determine the safety of this procedure. METHODS:  This prospective exploratory study included 10 consecutive patients with FAP and MDAs who underwent CSP for as many as 50 duodenal adenomas. The primary outcome was the incidence of severe adverse events...
January 19, 2018: Endoscopy
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#2
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
January 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29350355/the-biosorption-of-cadmium-and-cobalt-and-iron-ions-by-yeast-cryptococcus-humicola-at-nitrogen-starvation
#3
Tatiana Kulakovskaya, Lyubov Ryazanova, Anton Zvonarev, Galina Khokhlova, Vladimir Ostroumov, Mikhail Vainshtein
Yeasts Cryptococcus humicola accumulated cadmium, cobalt, and iron (~ 50, 17, and 4% of the content in the medium, respectively) from the medium containing glucose, phosphate, and 2 mmol/L of metal salts. The effects of metal absorption on the levels of orthophosphate (Pi) and inorganic polyphosphate (polyP) varied for the metals under study. The levels of Pi and polyP increased in the case of cadmium and cobalt, respectively. In the case of iron, no changes in the levels of Pi and polyP were observed. Multiple DAPI-stained polyP inclusions were observed in the cytoplasm of cadmium-containing cells...
January 19, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29349606/well-differentiated-liposarcoma-atypical-lipomatous-tumor-presenting-as-an-esophageal-polyp
#4
Aoife J McCarthy, Paul Carroll, Rajkumar Vajpeyi, Gail Darling, Runjan Chetty
No abstract text is available yet for this article.
January 19, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29346486/treatment-outcomes-and-adverse-events-following-in-office-angiolytic-laser-with-or-without-concurrent-polypectomy-for-vocal-fold-polyps
#5
Yu-Hsuan Lin, Chi-Te Wang, Feng-Chuan Lin, Li-Jen Liao, Wu-Chia Lo, Po-Wen Cheng
Importance: In-office angiolytic laser procedures have been used successfully as an alternative treatment for vocal fold polyps; little is known in detail about the treatment outcomes and adverse events. Objective: To examine the outcomes and incidence rates of adverse events associated with in-office angiolytic laser procedures with or without concurrent polypectomy as an alternative treatment for vocal fold polyps. Design, Setting, and Participants: Retrospective cohort study at a tertiary medical center...
January 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29344790/prospective-analysis-of-delayed-colorectal-post-polypectomy-bleeding
#6
Soo-Kyung Park, Jeong Yeon Seo, Min-Gu Lee, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jung, Ho-Kyung Chun, Dong Il Park
BACKGROUNDS/AIMS: Although post-polypectomy bleeding is the most frequent complication after colonoscopic polypectomy, only few studies have investigated the incidence of bleeding prospectively. The aim of this study was to investigate the incidence of delayed post-polypectomy bleeding and its associated risk factors prospectively. METHODS: Patients who underwent colonoscopic polypectomy at Kangbuk Samsung Hospital from January 2013 to December 2014 were prospectively enrolled in this study...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344569/endoscopic-full-thickness-resection-with-an-over-the-scope-clip-device-ftrd-in-the-colorectum-results-from-a-university-tertiary-referral-center
#7
Francesco Vitali, Andreas Naegel, Juergen Siebler, Markus F Neurath, Timo Rath
Background and study aims:  The full-thickness resection device (FTRD) represents a novel endoscopic treatment method for lesions unresectable with conventional endoscopic techniques. The overall aim of this study was to evaluate technical success and in toto resection rates, recurrence rates, as well as immediate or late complications in patients who underwent polyp removal with the FTRD. Patients and methods:  Data from a prospectively collected database of 12 patients who underwent 13 over-the-scope clip-based full-thickness resections between June 2015 and June 2017 were analyzed...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29344228/expression-and-clinical-significance-of-atm-and-puma-gene-in-patients-with-colorectal-cancer
#8
Hui Xiong, Jiangnan Zhang
The expression of ataxia-telangiectasia mutated (ATM) and p53 upregulated modulator of apoptosis (PUMA) genes in patients with colorectal cancer were investigated, to explore the correlation between the expression of ATM and PUMA and tumor development, to evaluate the clinical significance of ATM and PUMA in the treatment of colorectal cancer. Quantitative real-time PCR was used to detect the expression of ATM and PUMA in tumor tissue and adjacent healthy tissue of 67 patients with colorectal cancer and in normal colorectal tissue of 33 patients with colorectal polyps at mRNA level...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344224/long-term-outcomes-of-microwave-endometrial-ablation-for-treatment-of-patients-with-menorrhagia-a-retrospective-cohort-study
#9
Kohei Nakamura, Kentaro Nakayama, Kaori Sanuki, Toshiko Minamoto, Tomoka Ishibashi, Emi Sato, Hitomi Yamashita, Masako Ishikawa, Satoru Kyo
This study aimed to describe the long-term outcomes of patients with menorrhagia treated with microwave endometrial ablation (frequency, 2.45 GHz), as well as to identify factors associated with recurrence or re-surgery. This retrospective cohort study was conducted from 2007 to 2015 at Shimane University Hospital in Japan. Patients with severe menorrhagia and a desire to preserve their uterus were included in the study. Clinical factors associated with recurrence of menorrhagia or re-surgery were analyzed with a multivariable logistic regression model...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-%C3%A2-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#10
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29339825/corallivory-and-the-microbial-debacle-in-two-branching-scleractinians
#11
Yvan Bettarel, Sébastien Halary, Jean-Christophe Auguet, Thanh Chi Mai, Ngoc Van Bui, Thierry Bouvier, Patrice Got, Corinne Bouvier, Sonia Monteil-Bouchard, Desnues Christelle
The grazing activity by specific marine organisms represents a growing threat to the survival of many scleractinian species. For example, the recent proliferation of the corallivorous gastropod Drupella now constitutes a critical case in all South-East Asian waters. If the damaging effects caused by this marine snail on coral polyps are relatively well known, the indirect incidence of predation on coral microbial associates is still obscure and might also potentially impair coral health. In this study, we compared the main ecological traits of coral-associated bacterial and viral communities living in the mucus layer of Acropora formosa and Acropora millepora, of healthy and predated individuals (i...
January 16, 2018: ISME Journal
https://www.readbyqxmd.com/read/29339485/elevated-d-2-hydroxyglutarate-during-colitis-drives-progression-to-colorectal-cancer
#12
Jie Han, Dakota Jackson, Janette Holm, Kevin Turner, Paula Ashcraft, Xuan Wang, Beth Cook, Erland Arning, Robert M Genta, K Venuprasad, Rhonda F Souza, Lawrence Sweetman, Arianne L Theiss
d-2-hydroxyglutarate (D2HG) is produced in the tricarboxylic acid cycle and is quickly converted to α-ketoglutarate by d-2-hydroxyglutarate dehydrogenase (D2HGDH). In a mouse model of colitis-associated colon cancer (CAC), urine level of D2HG during colitis correlates positively with subsequent polyp counts and severity of dysplasia. The i.p. injection of D2HG results in delayed recovery from colitis and severe tumorigenesis. The colonic expression of D2HGDH is decreased in ulcerative colitis (UC) patients at baseline who progress to cancer...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29338827/risk-factors-of-intrauterine-adhesion-after-hysteroscopic-resection-of-endometrial-polyps
#13
Li Su, Lan You, Hong Ping Huang
Objective To analyze the risk factors of intrauterine adhesion (IUA) after hysteroscopic resection of endometrial polyps. Methods Totally 359 patients undergoing hysteroscopic resection of endometrial polyps from January 2013 to December 2016 were enrolled in this study. The clinical data of IUA group and non-IUA group were compared. Univariate analysis was performed to identify the risk factors of IUA,and multivariate Logistic regression analysis was further performed to get the independent risk factors. Results Of these 359 patients,IUA occured after operation in 56 patients (15...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29337425/distinct-gene-expression-profiles-and-regulation-networks-of-nasal-polyps-in-eosinophilic-and-non-eosinophilic-chronic-rhinosinusitis
#14
Naoko Okada, Tsuguhisa Nakayama, Daiya Asaka, Natsuki Inoue, Tadao Tsurumoto, Shinya Takaishi, Nobuyoshi Otori, Hiromi Kojima, Akio Matsuda, Keisuke Oboki, Hirohisa Saito, Kenji Matsumoto, Mamoru Yoshikawa
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, is distinguished from other non-eosinophilic CRSwNP (NECRSwNP) types. However, the pathogenesis of each remains unclear. METHODS: Nasal polyp tissues from ECRS (ECRSwNP) and NECRS (NECRSwNP) patients were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29337039/the-presence-of-small-and-diminutive-proximal-hyperplastic-polyps-is-associated-with-higher-rates-of-synchronous-advanced-neoplasia-compared-with-patients-without-serrated-lesions
#15
Hamoudah Thayer, Ma Karen, Esteban Marcus, Hayat Waqas, Mahon Brett, Jakate Shriram, Melson Joshua
BACKGROUND: The association of proximal small and diminutive hyperplastic polyps (HPs) with synchronous neoplasia (AN) is not well defined. However, sessile serrated polyps, even when small, are known to portend synchronous neoplastic risk. Currently, when proximal small hyperplastic polyps are detected, the USMTF does not recommend a change in surveillance interval. We aimed to compare the rates of synchronous AN in a screening colonoscopy cohort of patients with small and then diminutive proximal HPs in comparison, first to a cohort absent any serrated or proximal hyperplastic polyps, and then in comparison with a cohort with small proximal sessile serrated polyps (SSPs)...
January 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29337030/nasal-il-25-predicts-the-response-to-oral-corticosteroid-in-chronic-rhinosinusitis-with-nasal-polyps-crswnp
#16
Haiyu Hong, Fenghong Chen, Yueqi Sun, Qintai Yang, Wenxiang Gao, Yujie Cao, Yunping Fan, Jianbo Shi, Huabin Li
No abstract text is available yet for this article.
January 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29336288/how-often-is-sinus-surgery-performed-for-chronic-rhinosinusitis-with-versus-without-nasal-polyps
#17
Elisabeth H Ference, Jeffrey D Suh, Bruce K Tan, Stephanie Shintani Smith
BACKGROUND: There currently are no data on the relative frequency of endoscopic sinus surgeries (ESS) performed for chronic rhinosinusitis with nasal polyposis (CRSwNP) versus chronic rhinosinusitis without nasal polyposis (CRSsNP) in the United States. OBJECTIVES: To compare the rate of surgical interventions for CRSwNP and CRSsNP. METHODS: Cases identified by CPT codes were extracted from the 2009-2011 State Ambulatory Surgery Databases for California, Florida, Maryland, and New York...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336282/role-of-group-2-innate-lymphocytes-in-aspirin-exacerbated-respiratory-disease-pathogenesis
#18
Andrew A White, Taylor A Doherty
Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic nasal polyps, asthma, and airway reactions upon cyclooxygenase (COX) 1 inhibition. AERD is present in up to 7% of adult patients with asthma and the underlying pathogenesis remains largely elusive but prostaglandin D2, cysteinyl leukotrienes, mast cells, and type 2 cytokines are thought to contribute. A wealth of studies have recently implicated group 2 innate lymphoid cells (ILC2), a novel lineage-negative lymphocyte population that produces type 2 cytokines, in human allergic disease pathogenesis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336281/naive-and-effector-b-cell-subtypes-are-increased-in-chronic-rhinosinusitis-with-polyps
#19
Dijana Miljkovic, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Recent studies demonstrated that B cells and their chemoattractants are elevated in the nasal mucosa of patients with chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP). However, the presence of naive B cells and of plasmablasts and memory B-cell subsets in the mucosa and periphery of the same patient with CRS is yet to be characterized. OBJECTIVE: Here we sought to quantify naive, plasmablasts, and memory B cells in mucosal tissue and peripheral blood of patients with CRSwNP, patients with CRS without nasal polyps (CRSsNP), and control patients...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29335042/training-and-assessment-in-functional-endoscopic-sinus-surgery
#20
M Chan, S Carrie
BACKGROUND: Functional endoscopic sinus surgery is a common procedure performed within otolaryngology, but it carries potential for significant life-changing complications. It is therefore essential that trainees undergo adequate training. The European Working Time Directive has led to reduced operating time for the trainee surgeon. With variable access and the cost implications associated with cadaveric specimens, simulation can be an invaluable educational resource in surgical training...
January 16, 2018: Journal of Laryngology and Otology
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