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https://www.readbyqxmd.com/read/29149427/the-impact-of-the-national-bowel-screening-program-in-the-netherlands-on-detection-and-treatment-of-endoscopically-unresectable-benign-polyps
#1
C C M Marres, C J Buskens, E Schriever, P C M Verbeek, M W Mundt, W A Bemelman, A W H van de Ven
BACKGROUND: In January 2014, a national bowel cancer screening program started in the Netherlands. The program is being implemented in phases until 2019. Due to this program, an increase in patients referred for a colorectal resection for benign, but endoscopically unresectable polyps, is expected. So far, most resections are performed according to oncological principles despite no pre-operative histological diagnosis of malignancy. The aim of this study was to analyze the increase in referred patients during the first year of the screening program and to compare pathological results and clinical outcome of resections of patients undergoing resection for benign polyps before and after implementation of screening...
November 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#2
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29148567/silenced-dmbt1-promotes-nasal-mucosa-epithelial-cell-growth
#3
Xiaoqing Lu, Yaping Xu, Yu Zhao, Qilei Tao, Jian Wu
OBJECTIVE: The aim of this study was to investigate the role of the deleted in malignant brain tumors 1 (DMBT1) gene in the development of nasal polyps, as well as related mechanisms. METHODS: A stable human nasal mucosa epithelial cell (HNEpC) line with low expression of DMBT1 was generated. Three groups were established: a control group (HNEpCs without any treatment), a control short interference RNA (shRNA) group (HNEpCs transfected with an empty vector), and a DMBT1 shRNA group (HNEpCs with silenced DMBT1)...
November 17, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/29148535/the-role-of-apc-in-wnt-pathway-activation-in-serrated-neoplasia
#4
Jennifer Borowsky, Troy Dumenil, Mark Bettington, Sally-Ann Pearson, Catherine Bond, Lochlan Fennell, Cheng Liu, Diane McKeone, Christophe Rosty, Ian Brown, Neal Walker, Barbara Leggett, Vicki Whitehall
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin immunolocalization as a surrogate for WNT pathway activation and analyzed the entire APC gene coding sequence in serrated and conventional pathway polyps and cancers. WNT pathway activation was a common event in conventional pathway lesions with aberrant nuclear immunolocalization of β-catenin and truncating APC mutations in 90% and 89% of conventional adenomas and 82% and 70% of BRAF wild-type cancers, respectively...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29148098/absence-or-mislocalization-of-dnah5-is-a-characteristic-marker-for-motile-ciliary-abnormality-in-nasal-polyps
#5
Qianhui Qiu, Yang Peng, Zhenchao Zhu, Zhuo Chen, Chi Zhang, Hsiao Hui Ong, Kai Sen Tan, Haiyu Hong, Yan Yan, Haoqi Huang, Jing Liu, Xianqing Li, H N Nam, N T N Dung, Li Shi, Qintai Yang, Colin D Bingle, De-Yun Wang
OBJECTIVE: Motile cilia impairment is a common condition in patients with chronically inflamed airways, such as is seen in nasal polyps (NPs). The mechanism underlying this pathogenic condition is complex and not fully understood. METHODS: We investigated the presence and localization of dynein axonemal heavy chain 5 (DNAH5) in motile cilia using immunofluorescence staining in paraffin-embedded nasal biopsies from NPs (n = 120) and inferior turbinate mucosa (n = 35) of healthy controls...
November 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29147879/increased-risk-for-colon-polyps-in-patients-with-reflux-disease
#6
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies have found an increased risk for colonic neoplasm in patients with Barrett's esophagus. It is unknown whether such risk applies similarly to other types of gastroesophageal reflux disease (GERD). AIMS: To test whether GERD represents a risk factor for the occurrence of colon polyps. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA...
November 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29146203/responses-of-reef-building-corals-to-microplastic-exposure
#7
Jessica Reichert, Johannes Schellenberg, Patrick Schubert, Thomas Wilke
Pollution of marine environments with microplastic particles (i.e. plastic fragments <5 mm) has increased rapidly during the last decades. As these particles are mainly of terrestrial origin, coastal ecosystems such as coral reefs are particularly threatened. Recent studies revealed that microplastic ingestion can have adverse effects on marine invertebrates. However, little is known about its effects on small-polyp stony corals that are the main framework builders in coral reefs. The goal of this study is to characterise how different coral species I) respond to microplastic particles and whether the exposure might II) lead to health effects...
November 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29142518/local-recurrence-and-subsequent-endoscopic-treatment-after-endoscopic-piecemeal-mucosal-resection-with-or-without-precutting-in-the-colorectum
#8
Myeongsook Seo, Eun Mi Song, Gwang Un Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Background/Aims: Precutting before endoscopic piecemeal mucosal resection (EPMR) may increase colorectal polyp resection effectiveness. We aimed to identify risk factors for recurrence after conventional EPMR (CEPMR) and precut EPMR (PEPMR) and investigated endoscopic treatment outcomes for recurrent cases. Methods: The medical records of patients with colorectal polyps treated by EPMR were analyzed. Patients without follow-up surveillance colonoscopies were excluded...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29142363/multiple-colorectal-adenomas-syndrome-with-malignant-degeneration-in-multiple-colorectal-polyps-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-findings
#9
Punit Sharma
Multiple colorectal adenomas (MCRAs) syndrome is a genetic syndrome characterized by multiple colorectal polyps. Patients usually present late in late fourth or fifth decade of life. They have a high risk for developing malignancy. We here present such case of a 61-year-old man with MCRAs who developed malignant degeneration of multiple colorectal polyps, which was demonstrated on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography.
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29142168/background-data-on-nod-shi-scid-il-2r%C3%AE-null-mice-nog-mice
#10
Kenichiro Kasahara, Yachiyo Fukunaga, Saori Igura, Rie Andoh, Tsubasa Saito, Isamu Suzuki, Hiroyuki Kanemitsu, Daisuke Suzuki, Ken Goto, Daichi Nakamura, Masahiro Mochizuki, Masahiko Yasuda, Ryo Inoue, Kazutoshi Tamura, Mariko Nagatani
To obtain background data of NOD/Shi-scid IL-2Rγ(null) (NOG) mice, severely immunedeficient mice, a total of 120 animals were examined at 7, 26 and 52 weeks-old (20 mice/sex/group). The survival rate at 52 weeks-old was 95% (19/20) in both sexes. Clinically, circling behavior in one direction along the cage wall was observed in males after 8 weeks and females after 47 weeks-old, and hunchback position was found in males after 32 weeks-old. Hematologically, lymphocyte count markedly decreased at all ages, while white blood cell count increased in several mice at 52 weeks-old...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29141268/gastric-adenocarcinoma-and-proximal-polyposis-of-the-stomach-gapps-a-rare-recently-described-gastric-polyposis-syndrome-report-of-a-case
#11
Andrea Beer, Berthold Streubel, Reza Asari, Clemens Dejaco, Georg Oberhuber
In rare cases with multiple gastric polyps in the corpus and fundus, a recently described gastric polyposis syndrome called gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) has to be considered. We report on the findings in a patient fulfilling the criteria of this disease.A female patient born in 1977 underwent gastroscopy in 2005 due to recurrent abdominal pain. Endoscopy revealed more than 100 fundic gland polyps in the corpus and fundus. An ileocolonoscopy was inconspicuous. The patient did not take proton pump inhibitors...
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29136951/chemopreventive-effect-of-myricetin-a-natural-occurring-compound-on-colonic-chronic-inflammation-and-inflammation-driven-tumorigenesis-in-mice
#12
Mei-Jia Zhang, Han Su, Jing-Yue Yan, Na Li, Zhi-Yu Song, Huai-Jie Wang, Lian-Guang Huo, Feng Wang, Wan-Sheng Ji, Xian-Jun Qu, Mei-Hua Qu
Myricetin is a flavonoids compound extracted from edible myrica rubra. We aimed to evaluate the efficacy of Myricetin on colonic chronic inflammation and inflammation-driven tumorigenesis in mice. Myricetin was administrated by gavage for 4 consecutive weeks. Mice were sacrificed and the number of colonic polyps was counted. Myricetin significantly inhibited AOM/DSS-induced colitis and colorectal tumorigenesis. Myricetin prevented the incidence of colorectal tumorigenesis and reduced the size of colorectal polyps...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136699/-gastrointestinal-hamartomatous-polyps
#13
L Li, X S Fan
No abstract text is available yet for this article.
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29136630/one-to-one-correspondence-locations-of-resected-polyps-after-endoscopic-resection-using-catcher-tagged-method-a-randomized-prospective-study
#14
Hirohito Mori, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Seiki Kobayashi, Takaharu Yagi, Tsutomu Masaki
BACKGROUND/AIMS: Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but also enables the easiest retrieval in a short time without any special device. METHODS: One hundred thirty five patients (483 polyps) were diagnosed with colorectal neoplasm, and 64 patients (225 polyps) were enrolled and randomly allocated into the Net forceps group (NET) and the Catcher Tagged group (TAG)...
November 14, 2017: Digestion
https://www.readbyqxmd.com/read/29134135/polypoidal-choroidal-vasculopathy-on-swept-source-optical-coherence-tomography-angiography-with-variable-interscan-time-analysis
#15
Carl B Rebhun, Eric M Moult, Eduardo A Novais, Carlos Moreira-Neto, Stefan B Ploner, Ricardo N Louzada, ByungKun Lee, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed, Daniela Ferrara
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA)...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29133257/comparative-efficacy-of-colonoscope-distal-attachment-devices-in-increasing-rates-of-adenoma-detection-a-network-meta-analysis
#16
REVIEW
Antonio Facciorusso, Valentina Del Prete, Rosario Vincenzo Buccino, Nicola Della Valle, Maurizio Cosimo Nacchiero, Fabio Monica, Renato Cannizzaro, Nicola Muscatiello
BACKGROUND & AIMS: Several add-on devices have been developed to increase rates of colon adenoma detection (ADR). We assessed their overall and comparative efficacy, and estimated absolute magnitude of benefit through a network meta-analysis. METHODS: We searched the PubMed/Medline and Embase database through March 2017 and identified 25 randomized controlled trials (comprising 16,103 patients) that compared the efficacy of add-on devices (cap, Endocuff, and Endorings) with each other or with standard colonoscopy...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29133196/cold-endoscopic-mucosal-resection-of-large-sessile-serrated-polyps-at-colonoscopy-with-video
#17
Nicholas J Tutticci, David G Hewett
BACKGROUND AND AIMS: The optimal technique for the resection of sessile serrated polyps (SSPs) is unknown, with established limitations and risks with conventional polypectomy. Although cold snare polypectomy is safe, the efficacy of piecemeal resection for large lesions is untested. In this study, we evaluate the safety and efficacy of cold endoscopic mucosal resection (EMR) for large SSPs. METHODS: Patients presenting for elective colonoscopy at an academic endoscopy center with 1 or more SSPs ≥10mm in size were enrolled, excluding those on anticoagulants or antiplatelets other than aspirin...
November 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29132958/transforming-growth-factor-%C3%AE-1-decreases-epithelial-tight-junction-integrity-in-chronic-rhinosinusitis-with-nasal-polyps
#18
Jian Jiao, Ming Wang, Su Duan, Yifan Meng, Na Meng, Ying Li, Erzhong Fan, Cezmi Akdis, Luo Zhang
No abstract text is available yet for this article.
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132333/oestrogen-receptor-beta-isoform-expression-in-sporadic-colorectal-cancer-familial-adenomatous-polyposis-and-progressive-stages-of-colorectal-cancer
#19
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. METHODS: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29132174/feasibility-safety-and-diagnostic-yield-of-the-extra-wide-angle-view-ewave-colonoscope-for-the-detection-of-colorectal-lesions
#20
Maxime E S Bronzwaer, Evelien Dekker, Vincens Weingart, Stefan Groth, Mathieu Pioche, Jérôme Rivory, Torsten Beyna, Horst Neuhaus, Thierry Ponchon, Hans Allescher, Paul Fockens, Thomas Rösch
Background and study aims The adenoma detection rate (ADR) of conventional colonoscopy can still be improved. We conducted a prospective multicenter cohort study to assess the feasibility, safety, and diagnostic yield of the Extra Wide Angle View (EWAVE) colonoscope, which offers a 235° view obtained from a forward-viewing and two lateral backward-viewing lenses incorporated into one image. Patients and methods The study was performed between November 2015 and June 2016. EWAVE colonoscopy was performed in patients with an increased risk of colorectal cancer by experienced and EWAVE-trained endoscopists (≥ 500 colonoscopies, ≥ 10 with the EWAVE system)...
November 13, 2017: Endoscopy
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