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JOURNAL ARTICLE
Menglan Zhai, Zhenyu Lin, Haihong Wang, Jinru Yang, Mingjie Li, Xin Li, Lan Zhang, Tao Zhang
BACKGROUND: Standardized assessments of clinical complete response (cCR) to neoadjuvant chemoradiotherapy (nCRT) for rectal cancer have been established, but their utility and accuracy remain unclear. This study aimed to evaluate the clinical diagnostic value of rectal magnetic resonance imaging (MRI) and endorectal ultrasonography (ERUS) for the determination of cCRs after neoadjuvant immunotherapy and to investigate the concordance between cCR and pathological complete response (pCR)...
2024: Gastroenterology Report
#2
JOURNAL ARTICLE
Felix Holl, Lauren Clarke, Thomas Raffort, Elvire Serres, Laura Archer, Panu Saaristo
BACKGROUND: The Red Cross and Red Crescent Movement (RCRC) utilizes specialized Emergency Response Units (ERUs) for international disaster response. However, data collection and reporting within ERUs have been time-consuming and paper-based. The Red Cross Red Crescent Health Information System (RCHIS) was developed to improve clinical documentation and reporting, ensuring accuracy and ease of use while increasing compliance with reporting standards. CASE PRESENTATION: RCHIS is an Electronic Medical Record (EMR) and Health Information System (HIS) designed for RCRC ERUs...
April 8, 2024: Conflict and Health
#3
JOURNAL ARTICLE
Riccardo Campi, Alessio Pecoraro, Federico Piramide, Maria Lucia Gallo, Sergio Serni, Alex Mottrie, Angelo Territo, Karel Decaestecker, Alberto Breda
PURPOSE: Robot-assisted kidney transplantation (RAKT) is being increasingly performed at selected referral institutions worldwide. Yet, surgical training in RAKT is still unstructured and not grounded into formal credentialing courses including simulation, lab facilities, and modular training with animal models. As such, developing standardized, modular training programs is warranted to provide surgeons with the RAKT-specific skillset needed for a "safe" learning curve. METHODS: The 3-day course on RAKT developed at the EAU Skills Center in Orsi Academy was designed as a standardized, modular, step-by-step approach aiming to provide theoretical and practical skills...
March 30, 2024: World Journal of Urology
#4
JOURNAL ARTICLE
Junhao Wen, Bingxin Zhao, Zhijian Yang, Guray Erus, Ioanna Skampardoni, Elizabeth Mamourian, Yuhan Cui, Gyujoon Hwang, Jingxuan Bao, Aleix Boquet-Pujadas, Zhen Zhou, Yogasudha Veturi, Marylyn D Ritchie, Haochang Shou, Paul M Thompson, Li Shen, Arthur W Toga, Christos Davatzikos
The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10-8 ). A gene-drug-disease network highlighted genes linked to GM-BAG for treating neurodegenerative and neuropsychiatric disorders and WM-BAG genes for cancer therapy...
March 23, 2024: Nature Communications
#5
JOURNAL ARTICLE
C A Bravi, Filippo Turri, Paolo Dell'Oglio, Federico Piramide, Marcio Covas Moschovas, Ruben De Groote, Iulia Andras, Nikolaos Liakos, Fabrizio Di Maida, Edward Lambert, Mike Wenzel, Christoph Würnschimmel, Danny Darlington, Marco Paciotti, Chang Wook Jeong, Francesco Pellegrino, Giuseppe Basile, Peter Wiklund, Alexandre Mottrie, Alberto Breda, Alessandro Larcher
No abstract text is available yet for this article.
March 18, 2024: Journal of Robotic Surgery
#6
JOURNAL ARTICLE
Alessio Pecoraro, Angelo Territo, Romain Boissier, Vital Hevia, Thomas Prudhomme, Alberto Piana, Beatriz Bañuelos Marco, Anthony G Gallagher, Sergio Serni, Karel Decaestecker, Alberto Breda, Riccardo Campi
Standardized training programs for open (OKT) and robot-assisted kidney transplantation (RAKT) remain unmet clinical needs. To fill this gap, we designed a modified Delphi Consensus aiming to propose the first structured surgical curricula for both OKT and RAKT, involving a multispecialty international panel of experts. Two web-based surveys were built drafting two separate series of statements (for OKT and RAKT, respectively). The two surveys were delivered to a panel of 63 experts (for OKT) and 21 experts (for RAKT), selected considering their experience, academic profile and involvement in international associations...
February 2024: Minerva urology and nephrology
#7
JOURNAL ARTICLE
Alessio Pecoraro, Giuseppe Basile, Andrea Gallioli, Angelo Territo, Camille Berquin, Begoña Etcheverry, Josep Maria Gaya, Graziano Vignolini, Thomas Prudhomme, Milla Ortved, Philip Zeuschner, Rodrigo Garcia-Baquero, Malene Rohrsted, Michael Stoeckle, Nicolas Doumerc, Francesc Vigues, Sergio Serni, Riccardo Campi, Alberto Breda
No abstract text is available yet for this article.
April 2024: European urology open science
#8
JOURNAL ARTICLE
Xuemei Tang, Hongmei M Yuan, Xurong R Mu, Peng Gu, Pengfei Kong
The objective of this academic research is to assess the efficacy of conventional endorectal ultrasound (ERUS), ultrasonic shear wave elastography (SWE), and magnetic resonance imaging (MRI) techniques in evaluating the impact of neoadjuvant therapy (nCRT). Forty-five patients with advanced low rectal cancer (T ≥ 3) were included. Before and after nCRT, ERUS, SWE, and MRI evaluations were conducted. The T staging of ultrasound (uT) and MRI (mT) were evaluated and compared with the pathological T staging (ypT)...
February 19, 2024: Ultrasound Quarterly
#9
JOURNAL ARTICLE
Ioanna Skampardoni, Ilya M Nasrallah, Ahmed Abdulkadir, Junhao Wen, Randa Melhem, Elizabeth Mamourian, Guray Erus, Jimit Doshi, Ashish Singh, Zhijian Yang, Yuhan Cui, Gyujoon Hwang, Zheng Ren, Raymond Pomponio, Dhivya Srinivasan, Sindhuja Tirumalai Govindarajan, Paraskevi Parmpi, Katharina Wittfeld, Hans J Grabe, Robin Bülow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Daniel S Marcus, Pamela LaMontagne, Susan R Heckbert, Thomas R Austin, Lenore J Launer, Aristeidis Sotiras, Mark A Espeland, Colin L Masters, Paul Maruff, Jurgen Fripp, Sterling C Johnson, John C Morris, Marilyn S Albert, R Nick Bryan, Kristine Yaffe, Henry Völzke, Luigi Ferrucci, Tammie L S Benzinger, Ali Ezzati, Russell T Shinohara, Yong Fan, Susan M Resnick, Mohamad Habes, David Wolk, Haochang Shou, Konstantina Nikita, Christos Davatzikos
IMPORTANCE: Brain aging elicits complex neuroanatomical changes influenced by multiple age-related pathologies. Understanding the heterogeneity of structural brain changes in aging may provide insights into preclinical stages of neurodegenerative diseases. OBJECTIVE: To derive subgroups with common patterns of variation in participants without diagnosed cognitive impairment (WODCI) in a data-driven manner and relate them to genetics, biomedical measures, and cognitive decline trajectories...
February 14, 2024: JAMA Psychiatry
#10
JOURNAL ARTICLE
Marcio Covas Moschovas, Carlo Andrea Bravi, Paolo Dell'Oglio, Filippo Turri, Ruben de Groote, Nikolaos Liakos, Mike Wenzel, Christoph Würnschimmel, Fabrizio Di Maida, Federico Piramide, Iulia Andras, Alberto Breda, Alexandre Mottrie, Vipul Patel, Alessandro Larcher
PURPOSE: To access the current scenario of robotic-assisted radical prostatectomy training in multiple centers worldwide. METHODS: We created a multiple-choice questionnaire assessing all details of robotic-assisted radical prostatectomy training with 41 questions divided into three different categories (responder demography, surgical steps, and responder experience). The questionnaire was created and disseminated using the "Google Docs" platform. All responders had an individual invitation by direct message or Email...
January 27, 2024: World Journal of Urology
#11
JOURNAL ARTICLE
Wulan Tri Wahyuni, Budi Riza Putra, Hemas Arif Rahman, Weni Anindya, Jaya Hardi, Erus Rustami, Shahrul Nizam Ahmad
Herein, a nonenzymatic detection of paraoxon-ethyl was developed by modifying a glassy carbon electrode (GCE) with gold-silver core-shell (Au-Ag) nanoparticles combined with the composite of graphene with poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS). These core-shell nanoparticles (Au-Ag) were synthesized using a seed-growth method and characterized using UV-vis spectroscopy and high-resolution transmission electron microscopy (HR-TEM) techniques. Meanwhile, the structural properties, surface morphology and topography, and electrochemical characterization of the composite of Au-Ag core-shell/graphene/PEDOT:PSS were analyzed using infrared spectroscopy, field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), and electrochemical impedance spectroscopy (EIS) techniques...
January 16, 2024: ACS Omega
#12
Zhijian Yang, Junhao Wen, Guray Erus, Sindhuja T Govindarajan, Randa Melhem, Elizabeth Mamourian, Yuhan Cui, Dhivya Srinivasan, Ahmed Abdulkadir, Paraskevi Parmpi, Katharina Wittfeld, Hans J Grabe, Robin Bülow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Dahyun Yi, Daniel S Marcus, Pamela LaMontagne, Tammie L S Benzinger, Susan R Heckbert, Thomas R Austin, Shari R Waldstein, Michele K Evans, Alan B Zonderman, Lenore J Launer, Aristeidis Sotiras, Mark A Espeland, Colin L Masters, Paul Maruff, Jurgen Fripp, Arthur Toga, Sid O'Bryant, Mallar M Chakravarty, Sylvia Villeneuve, Sterling C Johnson, John C Morris, Marilyn S Albert, Kristine Yaffe, Henry Völzke, Luigi Ferrucci, Nick R Bryan, Russell T Shinohara, Yong Fan, Mohamad Habes, Paris Alexandros Lalousis, Nikolaos Koutsouleris, David A Wolk, Susan M Resnick, Haochang Shou, Ilya M Nasrallah, Christos Davatzikos
Brain aging is a complex process influenced by various lifestyle, environmental, and genetic factors, as well as by age-related and often co-existing pathologies. MRI and, more recently, AI methods have been instrumental in understanding the neuroanatomical changes that occur during aging in large and diverse populations. However, the multiplicity and mutual overlap of both pathologic processes and affected brain regions make it difficult to precisely characterize the underlying neurodegenerative profile of an individual from an MRI scan...
December 30, 2023: medRxiv
#13
JOURNAL ARTICLE
Zhijian Yang, Junhao Wen, Ahmed Abdulkadir, Yuhan Cui, Guray Erus, Elizabeth Mamourian, Randa Melhem, Dhivya Srinivasan, Sindhuja T Govindarajan, Jiong Chen, Mohamad Habes, Colin L Masters, Paul Maruff, Jurgen Fripp, Luigi Ferrucci, Marilyn S Albert, Sterling C Johnson, John C Morris, Pamela LaMontagne, Daniel S Marcus, Tammie L S Benzinger, David A Wolk, Li Shen, Jingxuan Bao, Susan M Resnick, Haochang Shou, Ilya M Nasrallah, Christos Davatzikos
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially reflecting disease subtypes that can be captured using MRI and machine learning methods. However, biological interpretability and treatment relevance are limited if the derived subtypes are not associated with genetic drivers or susceptibility factors. Herein, we describe Gene-SGAN - a multi-view, weakly-supervised deep clustering method - which dissects disease heterogeneity by jointly considering phenotypic and genetic data, thereby conferring genetic correlations to the disease subtypes and associated endophenotypic signatures...
January 8, 2024: Nature Communications
#14
RANDOMIZED CONTROLLED TRIAL
Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients.
Jeffrey N Browndyke, Lewis E Tomalin, Guray Erus, Jessica R Overbey, Amy Kuceyeski, Alan J Moskowitz, Emilia Bagiella, Alexander Iribarne, Michael Acker, Michael Mack, Joseph Mathew, Patrick O'Gara, Annetine C Gelijns, Mayte Suarez-Farinas, Steven R Messé
OBJECTIVE: Although acute brain infarcts are common after surgical aortic valve replacement (SAVR), they are often unassociated with clinical stroke symptoms. The relationship between clinically "silent" infarcts and in-hospital delirium remains uncertain; obscured, in part, by how infarcts have been traditionally summarized as global metrics, independent of location or structural consequence. We sought to determine if infarct location and related structural connectivity changes were associated with postoperative delirium after SAVR...
February 2024: Annals of Clinical and Translational Neurology
#15
JOURNAL ARTICLE
Francesco Pellegrino, Ugo Giovanni Falagario, Sophie Knipper, Alberto Martini, Olof Akre, Lars Egevad, Markus Aly, Marcio Covas Moschovas, Carlo Andrea Bravi, Joshua Tran, Yasmin Heiniger, Antonius von Kempis, Robin Schaffar, Giuseppe Carrieri, Alberto Briganti, Francesco Montorsi, Charles-Henry Rochat, Alexandre Mottrie, Thomas E Ahlering, Hubert John, Vipul Patel, Markus Graefen, Peter Wiklund
BACKGROUND: Positive surgical margins (PSMs) are frequent in patients undergoing radical prostatectomy (RP). The impact of PSMs on cancer-specific (CSM) and overall (OM) mortality has not yet been proved definitively. OBJECTIVE: To evaluate whether the presence and the features of PSMs were associated with CSM and OM in patients who underwent robotic-assisted RP. DESIGN, SETTING, AND PARTICIPANTS: A cohort of 8141 patients underwent robotic-assisted RP with >10 yr of follow-up...
December 27, 2023: European Urology Oncology
#16
JOURNAL ARTICLE
Jean-Luc E Cartron, F Jack Triepke, Dale W Stahlecker, David P Arsenault, Joseph L Ganey, Charles D Hathcock, Hunter K Thompson, Matthieu C Cartron, Kenneth C Calhoun
The high-resolution forecasting of vegetation type shifts may prove essential in anticipating and mitigating the impacts of future climate change on bird populations. Here, we used the US Forest Service Ecological Response Unit (ERU) classification to develop and assess vegetation-based breeding habitat profiles for eight owl species occurring in the foothills and mountains of the Southwestern US. Shifts in mapped habitat were forecast using an ecosystem vulnerability model based on the pre-1990 climate envelopes of ERUs and the Intergovernmental Panel on Climate Change's (IPCC) A1B moderate-emission scenario for the future climate...
December 6, 2023: Animals: An Open Access Journal From MDPI
#17
JOURNAL ARTICLE
Junhao Wen, Ilya M Nasrallah, Ahmed Abdulkadir, Theodore D Satterthwaite, Zhijian Yang, Guray Erus, Timothy Robert-Fitzgerald, Ashish Singh, Aristeidis Sotiras, Aleix Boquet-Pujadas, Elizabeth Mamourian, Jimit Doshi, Yuhan Cui, Dhivya Srinivasan, Ioanna Skampardoni, Jiong Chen, Gyujoon Hwang, Mark Bergman, Jingxuan Bao, Yogasudha Veturi, Zhen Zhou, Shu Yang, Paola Dazzan, Rene S Kahn, Hugo G Schnack, Marcus V Zanetti, Eva Meisenzahl, Geraldo F Busatto, Benedicto Crespo-Facorro, Christos Pantelis, Stephen J Wood, Chuanjun Zhuo, Russell T Shinohara, Ruben C Gur, Raquel E Gur, Nikolaos Koutsouleris, Daniel H Wolf, Andrew J Saykin, Marylyn D Ritchie, Li Shen, Paul M Thompson, Olivier Colliot, Katharina Wittfeld, Hans J Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S Marcus, Pamela LaMontagne, Susan R Heckbert, Thomas R Austin, Lenore J Launer, Mark Espeland, Colin L Masters, Paul Maruff, Jurgen Fripp, Sterling C Johnson, John C Morris, Marilyn S Albert, R Nick Bryan, Susan M Resnick, Yong Fan, Mohamad Habes, David Wolk, Haochang Shou, Christos Davatzikos
Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases. The genetic underpinnings of these patterns remain largely unknown. We apply a stochastic multivariate factorization method to a diverse population of 50,699 individuals (12 studies and 130 sites) and derive data-driven, multi-scale PSCs of regional brain size. PSCs were significantly correlated with 915 genomic loci in the discovery set, 617 of which are newly identified, and 72% were independently replicated...
December 26, 2023: Proceedings of the National Academy of Sciences of the United States of America
#18
Xinhui Wang, Lauren E Salminen, Andrew J Petkus, Ira Driscoll, Joshua Millstein, Daniel P Beavers, Mark A Espeland, Guray Erus, Meredith N Braskie, Paul M Thompson, Margaret Gatz, Helena C Chui, Susan M Resnick, Joel D Kaufman, Stephen R Rapp, Sally Shumaker, Mark Brown, Diana Younan, Jiu-Chiuan Chen
BACKGROUND: Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on the MTL were cross-sectional and focused on the hippocampus, yielding mixed results. METHOD: To determine whether air pollution exposures were associated with MTL atrophy over time, we conducted a longitudinal study including 653 cognitively unimpaired community-dwelling older women from the Women's Health Initiative Memory Study with two MRI brain scans (MRI-1: 2005-6; MRI-2: 2009-10; M age at MRI-1=77...
November 29, 2023: medRxiv
#19
JOURNAL ARTICLE
Federico Piramide, Filippo Turri, Daniele Amparore, Giuseppe Fallara, Ruben De Groote, Sophie Knipper, Christoph Wuernschimmel, Carlo Andrea Bravi, Edward Lambert, Fabrizio Di Maida, Nikolaos Liakos, Francesco Pellegrino, Iulia Andras, Alessandro Mastrorosa, Neeraja Tillu, Riccardo Mastroianni, Marco Paciotti, Mike Wenzel, Roberto Bianchi, Ettore di Trapani, Marcio Covas Moschovas, Giorgio Gandaglia, Marco Moschini, Frederiek D'Hondt, Bernando Rocco, Cristian Fiori, Antonio Galfano, Andrea Minervini, Giuseppe Simone, Alberto Briganti, Ottavio De Cobelli, Richard Gaston, Francesco Montorsi, Alberto Breda, Peter Wiklund, Francesco Porpiglia, Alexandre Mottrie, Alessandro Larcher, Paolo Dell'Oglio
BACKGROUND: Multiple and heterogeneous techniques have been described for orthotopic neobladder (ONB) reconstruction after robot-assisted radical cystectomy. Nonetheless, a systematic assessment of all the available options is lacking. OBJECTIVE: To provide the first comprehensive step-by-step description of all the available techniques for robotic intracorporeal ONB together with individual intraoperative, perioperative and functional outcomes based on a systematic review of the literature...
December 2, 2023: European Urology
#20
JOURNAL ARTICLE
Carlo A Bravi, Paolo Dell'Oglio, Pietro Piazza, Simone Scarcella, Lorenzo Bianchi, Ugo Falagario, Filippo Turri, Iulia Andras, Fabrizio Di Maida, Ruben De Groote, Federico Piramide, Marcio Covas Moschovas, Nazareno Suardi, Carlo Terrone, Giuseppe Carrieri, Vipul Patel, Riccardo Autorino, Francesco Porpiglia, Andrew Vickers, Alberto Briganti, Francesco Montorsi, Alexandre Mottrie, Alessandro Larcher
BACKGROUND: The learning curve for robot-assisted radical prostatectomy (RARP) remains controversial, with prior studies showing that, in contrast with evidence on open and laparoscopic radical prostatectomy, biochemical recurrence rates of experienced versus inexperienced surgeons did not differ. OBJECTIVE: To characterize the learning curve for positive surgical margins (PSMs) after RARP. DESIGN, SETTING, AND PARTICIPANTS: We analyzed the data of 13 090 patients with prostate cancer undergoing RARP by one of 74 surgeons from ten institutions in Europe and North America between 2003 and 2022...
November 29, 2023: European Urology Oncology
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