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Immunossupressant drugs

Julián Ernesto Nicolás Gulin, Margarita Bisio, Daniela Marisa Rocco, Jaime Altcheh, María Elisa Solana, Facundo García-Bournissen
Although many Trypanosoma cruzi (T. cruzi) strains isolated from a wide range of hosts have been characterized, there is a lack of information about biological features from vertically transmitted strains. We describe the molecular and biological characteristics of the T. cruzi VD strain isolated from a congenital Chagas disease patient. The VD strain was typified as DTU TcVI; in vitro sensitivity to nifurtimox (NFX) and beznidazole (BZ) were 2.88 μM and 6.19 μM respectively, while inhibitory concentrations for intracellular amastigotes were 0...
March 2018: Experimental Parasitology
Mariella Bau, Patricia Zacharias, Diogo Araújo Ribeiro, Larissa Boaron, Alvaro Steckert Filho, Paulo Gustavo Kotze
BACKGROUND: Infliximab and adalimumab are considered effective drugs in the management of Crohn's disease. However, due to significant immunossupression, they can cause important adverse events, mostly infections. OBJECTIVE: The aim of this study was to quantify and describe adverse events derived from adalimumab and infliximab use in Crohn's disease patients, and to compare the safety profile between these two agents. METHODS: This was an observational, single-center, longitudinal, retrospective study with Crohn's disease patients under infliximab or adalimumab therapy...
December 2017: Arquivos de Gastroenterologia
Ana Thereza Rocha, Marina Cabral, Eduardo Sad
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 01:30 PMINTRODUCTION: Sarcoidosis and Crohn's disease (CD) are characterized by granulomatous inflammation with heterogeneous systemic presentations. These diseases are rarely reported in the same patient, particularly in Latin America.CASE PRESENTATION: A 52 year-old caucasian male, non-smoker, with a four-year history of CD controlled with mesalazine (1600mg/day) presented with unremitting non-productive cough for 3 months, without hemoptysis, fever or weight loss...
October 1, 2012: Chest
Marta Esteves Guedes, José Nuno Galveia, Ana Catarina Almeida, João Marques Costa
Choroidal tuberculosis (TB) infection may present itself as a diffuse choroiditis that resembles serpiginous choroiditis, usually treated with immunossupressants. Recent studies have demonstrated that patients with serpiginous-like choroiditis and evidence of systemic or latent TB are best treated with antituberculosis treatment (ATT) in addition to the corticosteroid therapy. The authors present a case of a 58-year-old man with decreased vision in his left eye. His best-corrected visual acuity was 20/20 right eye and 20/200 left eye...
2011: BMJ Case Reports
Mara Medeiros-Domingo, Benjamín Romero-Navarro, Saúl Valverde-Rosas, Rodolfo Delgadillo, Gustavo Varela-Fascinetto, Ricardo Muñoz-Arizpe
Despite being considered a high risk procedure, renal transplantation has been recognized for more than 20 years as the best therapeutic option for children with end-stage renal disease since it is superior than any available dialytic procedure in improving the neuropsychological development and the quality of life. Today pediatric patients have similar graft survival than adults, and 10 year-old children or less have better outcome than any other age group. These remarking results are due to the development of specialized pediatric transplant centers and research programs, improvement in the selection and preparation of donors and recipients, refinement of the surgical technique and the use of new immunossupressive drugs...
March 2005: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
M Isabel T D Correia, Luciana Ordones Rego, Agnaldo Soares Lima
PURPOSE OF REVIEW: Post-liver transplant patients present a vast array of metabolic changes in the early and late phase which impact on their morbidity and mortality. The development of obesity and diabetes in these patients has been widely described in the literature with several hypotheses suggested: liver donor, nutritional and metabolic state, and immunosuppressive drugs. RECENT FINDINGS: Most that is known about the development of these metabolic derangements has been attributed to the drugs used, especially the corticosteroids...
July 2003: Current Opinion in Clinical Nutrition and Metabolic Care
P Gajdos
Myasthenia Gravis (MG) is an autoimmune disease characterized by the production of auto antibodies directed against the acetylcholine receptor of the neuro-muscular synapse. The signs and symptoms are a muscular deficit involving the spinal or cranial muscles. The degree of weakness changes spontaneously over shorter or longer periods. Some exacerbations, called myasthenia crisis, involve the respiratory muscle and are life-threatening. The prognosis of these crisis has been transformed by the use of mechanical ventilation...
May 2000: Annales de Médecine Interne
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