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https://www.readbyqxmd.com/read/29780563/chemical-structure-and-bonding-in-a-thorium-iii-aluminum-heterobimetallic-complex
#1
Alison B Altman, Alexandra C Brown, Guodong Rao, Trevor D Lohrey, R David Britt, Laurent Maron, Stefan G Minasian, David K Shuh, John Arnold
Thorium sits at a unique position on the periodic table. On one hand, there is little evidence that its 5f orbitals engage in bonding as they do in other early actinides; on the other hand, its chemistry is distinct from Lewis acidic transition metals. To gain insight into the underlying electronic structure of Th and develop trends across the actinide series, it is useful to study Th(iii) and Th(ii) systems with valence electrons that may engage in non-electrostatic metal-ligand interactions, although only a handful of such systems are known...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780553/reactivity-enhancement-of-a-diphosphene-by-reversible-n-heterocyclic-carbene-coordination
#2
Debabrata Dhara, Pankaj Kalita, Subhadip Mondal, Ramakirushnan Suriya Narayanan, Kaustubh R Mote, Volker Huch, Michael Zimmer, Cem B Yildiz, David Scheschkewitz, Vadapalli Chandrasekhar, Anukul Jana
Diphosphene TerMes P = PTerMes ( 1 ; TerMes = 2,6-Mes2 C6 H3 ; Mes = 2,4,6-Me3 C6 H2 ) and NHCMe4 2 (NHCMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) exist in an equilibrium mixture with the NHCMe4 -coordinated diphosphene 3 . While uncoordinated 1 is inert to hydrolysis, the NHC adduct 3 readily undergoes hydrolysis to afford a phosphino-substituted phosphine oxide with the liberation of NHCMe4 . On this basis, conditions suitable for the catalytic use of NHCMe4 were identified. Similarly, while the hydrogenation of free diphosphene 1 with H3 N·BH3 is very slow, 3 reacts instantaneously with H3 N·BH3 at room temperature to afford a dihydrodiphosphane...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29778685/methodology-of-spatial-risk-assessment-for-arsenic-species-associated-with-sampling-and-analysis-results-optimization
#3
Yimei Zhang, Liqun Wang, Jie Chen, Yalong Zhao, Yuxian Lai, Panpan Wu
The conventional risk assessment methods may be defective for more effective health risk assessment due to ignoring heavy metal species and the accuracy and integrity of sampling and analysis results. Using the accurate and integral data to quantify the human health effects of metal species can provide great support for more effective health risk assessment. This study presents a new methodology to optimize sampling and analysis results for implementing the spatial human health risk of heavy metal species in contaminated sites...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778197/genetic-analysis-and-biological-characteristics-of-different-internal-gene-origin-h5n6-reassortment-avian-influenza-virus-in-china-in-2016
#4
Wenqiang Sun, Jiaxin Li, Jiao Hu, Daxiu Jiang, Chaonan Xing, Tiansong Zhan, Xiufan Liu
Clade 2.3.4.4 of H5N6 subtype Avian Influenza Viruses (AIVs) has become dominant clade in South-East Asia. So far, a total of 16 cases of human infection, including 6 deaths, have been confirmed since 2014. In this study, we systematically investigated the genetic evolution and biological characteristics of these viruses. We first carried out phylogenetic and statistical analysis of all H5N6 viruses that were downloaded from Influenza Research Database, GISAID and isolates from our lab. We found that H5N6 AIVs continued to reassort with other AIVs subtypes since 2014...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29776551/integrated-atomic-layer-deposition-and-chemical-vapor-reaction-for-the-preparation-of-metal-organic-framework-coatings-for-solid-phase-microextraction-arrow
#5
Hangzhen Lan, Leo D Salmi, Tuukka Rönkkö, Jevgeni Parshintsev, Matti Jussila, Kari Hartonen, Marianna Kemell, Marja-Liisa Riekkola
New chemical vapor reaction (CVR) and atomic layer deposition (ALD)-conversion methods were utilized for preparation of metal organic frameworks (MOFs) coatings of solid phase microextraction (SPME) Arrow for the first time. With simple, easy and convenient one-step reaction or conversion, four MOF coatings were made by suspend ALD iron oxide (Fe2 O3 ) film or aluminum oxide (Al2 O3 ) film above terephthalic acid (H2 BDC) or trimesic acid (H3 BTC) vapor. UIO-66 coating was made by zirconium (Zr)-BDC film in acetic acid vapor...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29775417/targeting-histone-methyltransferase-enhancer-of-zeste-homolog-2-inhibits-renal-epithelial-mesenchymal-transition-and-attenuates-renal-fibrosis
#6
Xiaoxu Zhou, Chongxiang Xiong, Evelyn Tolbert, Ting C Zhao, George Bayliss, Shougang Zhuang
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial-mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 were highly expressed in mouse kidney with unilateral ureteral obstruction and cultured mouse kidney proximal tubular (TKPT) cells undergoing EMT. Inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) attenuated renal fibrosis, which was associated with preserving E-cadherin expression and inhibiting Vimentin up-regulation in the obstructed kidney...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29774413/alterations-in-histone-acetylation-following-exposure-to-60-co-%C3%AE-rays-and-their-relationship-with-chromosome-damage-in-human-lymphoblastoid-cells
#7
Xue-Lei Tian, Xue Lu, Jiang-Bin Feng, Tian-Jing Cai, Shuang Li, Mei Tian, Qing-Jie Liu
Chromosome damage is related to DNA damage and erroneous repair. It can cause cell dysfunction and ultimately induce carcinogenesis. Histone acetylation is crucial for regulating chromatin structure and DNA damage repair. Ionizing radiation (IR) can alter histone acetylation. However, variations in histone acetylation in response to IR exposure and the relationship between histone acetylation and IR-induced chromosome damage remains unclear. Hence, this study investigated the variation in the total acetylation levels of H3 and H4 in human lymphocytes exposed to 0-2 Gy 60 Co γ-rays...
May 17, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29774099/camptothecin-induces-g-2-m-phase-arrest-through-the-atm-chk2-cdc25c-axis-as-a-result-of-autophagy-induced-cytoprotection-implications-of-reactive-oxygen-species
#8
Rajapaksha Gedara Prasad Tharanga Jayasooriya, Matharage Gayani Dilshara, Ilandarage Menu Neelaka Molagoda, Cheol Park, Sang Rul Park, Seungheon Lee, Yung Hyun Choi, Gi-Young Kim
In the present study, we report that camptothecin (CPT) caused irreversible cell cycle arrest at the G2 /M phase, and was associated with decreased levels of cell division cycle 25C (Cdc25C) and increased levels of cyclin B1, p21, and phospho-H3. Interestingly, the reactive oxygen species (ROS) inhibitor, glutathione, decreased CPT-induced G2 /M phase arrest and moderately induced S phase arrest, indicating that the ROS is required for the regulation of CPT-induced G2 /M phase arrest. Furthermore, transient knockdown of nuclear factor-erythroid 2-related factor 2 (Nrf2), in the presence of CPT, increased the ROS' level and further shifted the cell cycle from early S phase to the G2 /M phase, indicating that Nrf2 delayed the S phase in response to CPT...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772399/characterization-of-a-g10p-14-rotavirus-strain-from-a-diarrheic-child-in-thailand-evidence-for-bovine-to-human-zoonotic-transmission
#9
Ratana Tacharoenmuang, Satoshi Komoto, Ratigorn Guntapong, Tomihiko Ide, Phakapun Singchai, Sompong Upachai, Saori Fukuda, Yumika Yoshida, Takayuki Murata, Tetsushi Yoshikawa, Kriangsak Ruchusatsawat, Kazushi Motomura, Naokazu Takeda, Somchai Sangkitporn, Koki Taniguchi
An unusual rotavirus strain, DB2015-066 with the G10P[14] genotype (RVA/Human-wt/THA/dB2015-066/2015/G10P[14]), was detected in a stool sample from a child hospitalized with acute gastroenteritis in Thailand. Here, we sequenced and characterized the full-genome of the strain DB2015-066. On whole genomic analysis, strain DB2015-066 was shown to have a unique genotype constellation: G10-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. The backbone genes of this strain (I2-R2-C2-M2-A3-N2-T6-E2-H3) are commonly found in rotavirus strains from artiodactyls such as cattle...
May 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29771114/controlled-polymerization-in-polar-solvents-to-ultrahigh-molecular-weight-polyethylene
#10
Philip Kenyon, Melissa Wörner, Stefan Mecking
Novel complexes based on 2,4,8-triarylnaphthylamine [[(2,4-{3,5-(CF3 )2 C6 H3 }2 -8-(3,5-R2 C6 H3 )-C10 H4 )-N═C(H)-{3-(9-anthryl)-2-O-C6 H3 }-κ2 -N,O]Ni(CH3 )(pyridine)] (4-Py, R = Me; 5-Py, R = CF3 ) were synthesized from 8-arylnaphthylamines which can be generated via selective lithiation, borylation, and coupling in a one-pot procedure. Due to their living characteristics in ethylene polymerization and the particularly low propensity of 5-Py for β-H elimination as reflected by a high linearity even at elevated polymerization temperatures of 60 °C, ultrahigh molecular weight polyethylene (UHMWPE) is formed in polar organic solvents (THF, diethyl ether) as a reaction medium in a controlled polymerization ( Mw / Mn = 1...
May 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29771107/design-and-synthesis-of-a-biocompatible-1d-coordination-polymer-as-anti-breast-cancer-drug-carrier-5-fu-in-vitro-and-in-vivo-studies
#11
Mahsa Rezaei, Alireza Abbasi, Rassoul Dinarvand, Mahmood Jeddi-Tehrani, Jan Janczak
Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H2 O)6 K2 (H2 BTC)2 (H2 O)4 ](H2 BTC)2 ·2H2 O, where H3 BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu)...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29765534/bi2536-induces-mitotic-catastrophe-and-radiosensitization-in-human-oral-cancer-cells
#12
Chieh-Yuan Cheng, Chung-Ji Liu, Yu-Chuen Huang, Shu-Hua Wu, Hsu-Wei Fang, Yu-Jen Chen
BI2536 has been developed as a potential therapeutic agent for various cancers but not in oral cancer cells. Since BI2536 exhibits mitosis-regulating activity which are the most radiosensitive, we hypothesized that BI2536 might modulate the radiosensitivity of oral cancer cells. Human normal fibroblasts, oral cancer SAS, and OECM1 cells were treated with BI2536 (0-50 nM) and/or radiation (0-4 Gy). MTT assay, Liu's staining, flow cytometry, clonogenic assay, Annexin V/propidium iodide (PI) staining, western blot analysis, and small interfering RNA knockdown experiments were used to assess cell viability, morphology, cell cycle progression, radiation survival, and expression of regulatory proteins in vitro ...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29763912/-a-succinate-ether-derivative-of-tocotrienol-enhances-dickkopf-1-gene-expression-through-epigenetic-alterations-in-malignant-mesothelioma-cells
#13
Ayami Sato, Haruka Ueno, Momoka Fusegi, Saki Kaneko, Kakeru Kohno, Nantiga Virgona, Akira Ando, Yuko Sekine, Tomohiro Yano
BACKGROUND: Wnt signaling plays an essential role in tumor cell growth, including the development of malignant mesothelioma (MM). Epigenetic silencing of negative Wnt regulators leading to constitutive Wnt signaling has been observed in various cancers and warrants further attention. We have reported that a succinate ether derivative of α-tocotrienol (T3E) has potent cytotoxic effects in MM cells. Thus, in this study, we investigated whether the anti-MM effect of T3E could be mediated via the epigenetic alteration of the Wnt antagonist gene, Dickkopf-1 (DKK1)...
May 15, 2018: Pharmacology
https://www.readbyqxmd.com/read/29762370/molecular-regulations-of-mucosal-maltase-expressions
#14
Toshinao Goda, Kazue Honma
Two major α-glucosidase (maltase) genes, sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM), respectively, are expressed in the small intestine. In this review, we have summarized whether jejunal expression of these maltase genes is regulated by dietary manipulations, which may affect carbohydrate availability from the luminal side, through changes in the binding of transcription factors and/or histone code on these genes. Studies using a model of mice fed either a low-starch or a high-starch diet for 7 days, found the mRNA levels of SI, MGAM, and Na-glucose cotransporter (SGLT1) genes in the jejunum to be increased in parallel by feeding a high-starch diet...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29759420/lysyl-oxidase-like-2-contributes-to-renal-fibrosis-in-col4%C3%AE-3-alport-mice
#15
Dominic Cosgrove, Brianna Dufek, Daniel T Meehan, Duane Delimont, Michael Hartnett, Gina Samuelson, Michael Anne Gratton, Grady Phillips, Deidre A MacKenna, Gretchen Bain
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize SNAIL, and reduce cell polarity. Although LOXL2 promotes liver and lung fibrosis, little is known regarding its role in renal fibrosis. Here we determine whether LOXL2 influences kidney disease in COL4A3 (-/-) Alport mice. These mice were treated with a small molecule inhibitor selective for LOXL2 or with vehicle and assessed for glomerular sclerosis and fibrosis, albuminuria, blood urea nitrogen, lifespan, pro-fibrotic gene expression and ultrastructure of the glomerular basement membrane...
May 11, 2018: Kidney International
https://www.readbyqxmd.com/read/29759229/evaluation-of-polar-organic-chemical-integrative-and-hollow-fibre-samplers-for-the-determination-of-a-wide-variety-of-organic-polar-compounds-in-seawater
#16
Leire Mijangos, Haizea Ziarrusta, Ailette Prieto, Oihane Zugazua, Olatz Zuloaga, Maitane Olivares, Aresatz Usobiaga, Albrecht Paschke, Nestor Etxebarria
The calibration of two passive samplers for the determination of 20 emerging organic compounds in seawater is described in this work: i) a new version of polar organic chemical integrative sampler (POCIS) containing 100 mg of mixed-mode anion exchanger (Strata X-AW) and 100 mg of polymeric HLB (Plexa) sorbent materials and using a highly porous Nylon membrane (30-μm pore size) and ii) polyethersulfone (PES) hollow fibre. Among the studied contaminants, herbicides, hormones, life style products (stimulants and artificial sweeteners), industrial chemicals (corrosion inhibitor and fluorinated compounds), personal care products and several pharmaceuticals were included...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757500/immunohistochemistry-for-histone-h3g34w-and-h3k36m-is-highly-specific-for-giant-cell-tumor-of-bone-and-chondroblastoma-respectively-in-fna-and-core-needle-biopsy
#17
Inga-Marie Schaefer, Jonathan A Fletcher, G Petur Nielsen, Angela R Shih, Marco L Ferrone, Jason L Hornick, Xiaohua Qian
BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific for GCT and chondroblastoma in surgical excisions. The objective of the current study was to validate H3G34W and H3K36M IHC in the diagnosis of giant cell-rich bone tumors on fine-needle aspiration and core needle biopsy specimens...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29754303/preparation-and-cr-vi-removal-performance-of-corncob-activated-carbon
#18
Hongyan Li, Pei Gao, Jianguo Cui, Feng Zhang, Fang Wang, Jici Cheng
Corncob activated carbon (CCAC) was prepared by a H3 PO4 activation method. The optimum conditions for the preparation of CCAC were determined by orthogonal experiments. The effects of pH, reaction time, CCAC dosage, and hexavalent chromium (Cr(VI)) concentrations on Cr(VI) removal by CCAC were studied. Corn straw activated carbon (CSAC) was also prepared using the optimum preparation conditions determined for CCAC. The properties of samples were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS)...
May 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29751847/asf1-is-required-to-load-histones-on-the-hira-complex-in-preparation-of-paternal-chromatin-assembly-at-fertilization
#19
Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy, Benjamin Loppin
BACKGROUND: Anti-Silencing Factor 1 (ASF1) is a conserved H3-H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an important role in regulating the supply of H3.1/2 and H4 to the CAF-1 chromatin assembly complex. ASF1 also provides H3.3-H4 dimers to HIRA and DAXX chaperones for RI nucleosome assembly. The early Drosophila embryo is an attractive system to study chromatin assembly in a developmental context...
May 11, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29745655/modulating-co-2-adsorption-in-metal-organic-frameworks-via-metal-ion-doping
#20
Ping Cui, Ji-Jing Li, Jie Dong, Bin Zhao
One novel metal-organic framework {[Ni6 (OH)4 (BTB)8/3 (H2 O)6 ]·4H2 O·9DMF} n (DMF = dimethylformamide) based on 1,3,5-benzenetribenzoic acid (H3 BTB) was successfully synthesized under basic condition at room temperature, featuring a unique twofold interpenetrated pcu-type net with [Ni6 (OH)4 (COO)8 (H2 O)6 ] cluster as building block. Its gas-adsorption behaviors were investigated and modified by utilizing metalII -doped procedure, which was certified to be a highly effective pathway in enhancing CO2 uptake capacity...
May 10, 2018: Inorganic Chemistry
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