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https://www.readbyqxmd.com/read/28526632/erythrocytosis-following-testosterone-therapy
#1
REVIEW
Samuel J Ohlander, Bibin Varghese, Alexander W Pastuszak
INTRODUCTION: A rapid increase in awareness of androgen deficiency has led to substantial increases in prescribing of testosterone therapy (TTh), with benefits of improvements in mood, libido, bone density, muscle mass, body composition, energy, and cognition. However, TTh can be limited by its side effects, particularly erythrocytosis. This review examines the literature on testosterone-induced erythrocytosis and polycythemia. AIM: To review the available literature on testosterone-induced erythrocytosis, discuss possible mechanisms for pathophysiology, determine the significance of formulation, and elucidate potential thromboembolic risk...
May 16, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28509904/immunological-effects-of-behavioral-activation-with-exercise-in-major-depression-an-exploratory-randomized-controlled-trial
#2
F Euteneuer, K Dannehl, A Del Rey, H Engler, M Schedlowski, W Rief
Major depression (MD) is associated with peripheral inflammation and increased cardiovascular risk. Regular physical exercise can have anti-inflammatory effects. The present study examined whether behavioral activation with exercise affects inflammatory processes in MD. Ninety-eight patients with MD were randomly assigned to cognitive-behavioral therapy (CBT) emphasizing exercise during behavioral activation (CBT-E), CBT with pleasurable low-energy activities as an active control condition (CBT-C) or a passive waiting list control group (WL)...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28505499/clinical-predictors-of-acute-response-to-transcranial-direct-current-stimulation-tdcs-in-major-depression
#3
Giordano D'Urso, Bernardo Dell'Osso, Rodolfo Rossi, Andre Russowsky Brunoni, Marco Bortolomasi, Roberta Ferrucci, Alberto Priori, Andrea de Bartolomeis, Alfredo Carlo Altamura
BACKGROUND: Transcranial direct current stimulation (tDCS) is a promising neuromodulation intervention for poor-responding or refractory depressed patients. However, little is known about predictors of response to this therapy. The present study aimed to analyze clinical predictors of response to tDCS in depressed patients. METHODS: Clinical data from 3 independent tDCS trials on 171 depressed patients (including unipolar and bipolar depression), were pooled and analyzed to assess predictors of response...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28495306/long-term-effects-of-enriched-environment-following-neonatal-hypoxia-ischemia-on-behavior-bdnf-and-synaptophysin-levels-in-rat-hippocampus-effect-of-combined-treatment-with-g-csf
#4
Myrsini Griva, Rosa Lagoudaki, Olga Touloumi, Evangelia Nousiopoulou, Filippos Karalis, Thomas Georgiou, Georgia Kokaraki, Constantina Simeonidou, Despina A Tata, Evangelia Spandou
Increasing evidence shows that exposure to an enriched environment (EE) is neuroprotective in adult and neonatal animal models of brain ischemia. However, the mechanisms underlying this effect remain unclear. The aim of the current study was to investigate whether post-weaning EE would be effective in preventing functional deficits and brain damage by affecting markers of synaptic plasticity in a neonatal rat model of hypoxia-ischemia (HI). We also examined the possibility that granulocyte-colony stimulating factor (G-CSF), a growth factor with known neuroprotective effects in a variety of experimental brain injury models, combined with EE stimulation could enhance the potential beneficial effect of EE...
May 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28484405/management-of-chronic-tinnitus-and-insomnia-with-repetitive-transcranial-magnetic-stimulation-and-cognitive-behavioral-therapy-a-combined-approach
#5
Kneginja Richter, Jens Acker, Lence Miloseva, Lukas Peter, Günter Niklewski
It has been estimated that up to 80% of people will experience symptoms of tinnitus over the courses of their lives, with rates of comorbid sleeping problems ranging from 50 to 77%. Because of a potential connection between tinnitus and sleep disorders as well as high rates of comorbid psychiatric disorders, interdisciplinary approaches to treatment seem to be the most efficient option. In this study, we present the case of a 53-year-old male patient, who started to experience symptoms of tinnitus at the age of 49, most likely caused by work-related stress...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28474552/new-directions-in-the-use-of-brain-stimulation-interventions-in-patients-with-obsessive-compulsive-disorder
#6
Bernardo Dell'Osso, Laura Cremaschi, Lucio Oldani, Altamura Alfredo Carlo
Obsessive-Compulsive Disorder (OCD) is a highly disabling condition with early onset and chronic course in most of the affected patients. In addition, OCD may show high comorbidity and suicide attempt rates, which worsen the overall burden of the disease for patients and their caregivers. First-line treatments for OCD consist of pro-serotonergic compounds and cognitive-behavioral therapy. Nonetheless, many patients show only limited benefit from such interventions and require additional "next-step" interventions, including augmentative antipsychotics and glutamate-modulating agents...
May 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28462986/music-based-therapeutic-interventions-for-people-with-dementia
#7
REVIEW
Jenny T van der Steen, Mirjam C van Soest-Poortvliet, Johannes C van der Wouden, Manon S Bruinsma, Rob Jpm Scholten, Annemiek C Vink
BACKGROUND: Dementia is a clinical syndrome with a number of different causes which is characterised by deterioration in cognitive, behavioural, social and emotional functions. Pharmacological interventions are available but have limited effect to treat many of the syndrome's features. Less research has been directed towards non-pharmacological treatments. In this review, we examined the evidence for effects of music-based interventions as a treatment. OBJECTIVES: To assess the effects of music-based therapeutic interventions for people with dementia on emotional well-being including quality of life, mood disturbance or negative affect, behavioural problems, social behaviour, and cognition at the end of therapy and four or more weeks after the end of treatment...
May 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28460127/effects-of-combining-a-brief-cognitive-intervention-with-transcranial-direct-current-stimulation-on-pain-tolerance-a-randomized-controlled-pilot-study
#8
Abigail Powers, Alok Madan, Megan Hilbert, Scott T Reeves, Mark George, Michael R Nash, Jeffrey J Borckardt
Objective.:  Cognitive behavioral therapy has been shown to be effective for treating chronic pain, and a growing literature shows the potential analgesic effects of minimally invasive brain stimulation. However, few studies have systematically investigated the potential benefits associated with combining approaches. The goal of this pilot laboratory study was to investigate the combination of a brief cognitive restructuring intervention and transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in affecting pain tolerance...
April 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28457185/deep-brain-stimulation-of-the-anterior-limb-of-the-internal-capsule-for-treatment-of-therapy-refractory-obsessive-compulsive-disorder-ocd-a-case-study-highlighting-neurocognitive-and-psychiatric-changes
#9
Tabina K Choudhury, Joyce E Davidson, Ashwin Viswanathan, Adriana M Strutt
Obsessive compulsive disorder (OCD) is an anxiety disorder characterized by repeated, unwanted thoughts and behaviors. Individuals with this condition often experience significant emotional distress secondary to their symptoms. Additionally, impairments in attention/concentration, processing speed, and executive functions are typically observed. The exact pathology of OCD remains unknown; consequently, it can be difficult to treat patients with severe symptomatology. Deep brain stimulation (DBS) may be a viable treatment option for individuals who do not respond to medication and/or cognitive behavioral therapy...
May 1, 2017: Neurocase
https://www.readbyqxmd.com/read/28452348/wincs-harmoni-closed-loop-dynamic-neurochemical-control-of-therapeutic-interventions
#10
Kendall H Lee, J Luis Lujan, James K Trevathan, Erika K Ross, John J Bartoletta, Hyung Ook Park, Seungleal Brian Paek, Evan N Nicolai, Jannifer H Lee, Hoon-Ki Min, Christopher J Kimble, Charles D Blaha, Kevin E Bennet
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28451797/-repetitive-peripheral-muscle-stimulation-vs-pelvic-floor-muscle-training-comparison-of-two-approaches-to-incontinence-treatment
#11
Sabine Schrank, Laura Adlbrecht, Hanna Mayer
BACKGROUND: Although there are various measures for the prevention, treatment, and management of urinary incontinence (UI), absorbing aids (and only scant continence-promoting measures) are primarily used in nursing homes in Austria. Repetitive peripheral muscle stimulation (RPMS) is already used as a common method for the treatment and prevention of incontinence in the outpatient setting and is an effective alternative compared to the usual incontinence treatments. However, there are no empirical data as yet on the effect of RPMS in nursing home residents...
April 27, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28430533/new-directions-in-the-rational-design-of-electrical-and-magnetic-seizure-therapies-individualized-low-amplitude-seizure-therapy-ilast-and-magnetic-seizure-therapy-mst
#12
Thomas Radman, Sarah H Lisanby
Electroconvulsive therapy remains a key treatment option for severe cases of depression, but undesirable side-effects continue to limit its use. Innovations in the design of novel seizure therapies seek to improve its risk benefit ratio through enhanced control of the focality of stimulation. The design of seizure therapies with increased spatial precision is motivated by avoiding stimulation of deep brain structures implicated in memory retention, including the hippocampus. The development of two innovations in seizure therapy-individualized low-amplitude seizure therapy (iLAST) and magnetic seizure therapy (MST), are detailed...
April 21, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28429077/-implementation-of-the-german-s3-guidelines-on-dementia-in-clinical-practice-wish-or-reality
#13
H Lohmann, F Kulessa, H Holling, A Johnen, S Reul, G Lueg, T Duning
BACKGROUND: Published in 2009, the German S3 guidelines on dementia define a milestone in quality improvement of the diagnostics and treatment of dementia. In clinical practice patients suffering from dementia are primarily treated by physicians in private practice; therefore, this study examined how the guidelines are implemented in outpatient clinical settings. Furthermore, it aimed at the identification of behavioral determinants that govern the actual diagnostic and therapeutic approach in clinical practice...
April 20, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28427836/adherence-to-continuous-positive-airway-pressure-in-adults-with-an-intellectual-disability
#14
Kim A Luijks, Nele L Vandenbussche, Dirk Pevernagie, Sebastiaan Overeem, Sigrid Pillen
STUDY OBJECTIVES: This retrospective study evaluated the feasibility of continuous positive airway pressure (CPAP) therapy in adults with intellectual disabilities (ID). METHODS: CPAP therapy of 24 obstructive sleep apnea syndrome (OSA) patients with ID were compared to age- and sex-matched adults with normal cognitive functioning. All ID patients received an intensive in-hospital training protocol to stimulate adherence. Good adherence was defined as a use of >70% of the nights and >4 h/night...
March 30, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28427299/effects-of-low-frequency-repetitive-transcranial-magnetic-stimulation-on-upper-extremity-motor-recovery-and-functional-outcomes-in-chronic-stroke-patients-a-randomized-controlled-trial
#15
Ayhan Aşkın, Aliye Tosun, Ümit Seçil Demirdal
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) was suggested as a preconditioning method that would increase brain plasticity and that it would be optimal to combine rTMS with intensive rehabilitation. OBJECTIVE: To assess the efficacy of inhibitory rTMS on upper extremity motor recovery and functional outcomes in chronic ischemic stroke patients. METHODS: In this randomized controlled trial, experimental group received low-frequency (LF) rTMS to the primary motor cortex of the unaffected side + physical therapy (PT), and control group received PT...
April 20, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28424953/treatment-update-of-chronic-migraine
#16
REVIEW
Soo-Jin Cho, Tae-Jin Song, Min Kyung Chu
PURPOSE OF REVIEW: Although chronic migraine (CM) is a common disorder that severely impacts patient functioning and quality of life, it is usually underdiagnosed, and treatment responses often remain poor even after diagnosis. In addition, effective treatment options are limited due to the rarity of randomized controlled trials (RCTs) involving patients with CM. In the present review, we discuss updated pharmacological, non-pharmacological, and neurostimulation treatment options for CM...
June 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28418328/internet-based-intervention-for-tinnitus-outcome-of-a-single-group-open-trial
#17
Eldré W Beukes, Peter M Allen, Vinaya Manchaiah, David M Baguley, Gerhard Andersson
BACKGROUND: Managing chronic tinnitus is challenging, and innovative ways to address the resulting health-care burden are required. Internet-based cognitive behavioral therapy (iCBT) for tinnitus shows promise as a cost-effective treatment option. The feasibility and effectiveness of iCBT in the United Kingdom are yet to be explored. Furthermore, it is not known if iCBT can be supported by an audiologist rather than a psychologist. PURPOSE: This study aimed to determine the feasibility of guided iCBT using audiological support on tinnitus distress and tinnitus-related comorbidities...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28413833/beneficial-effects-of-a-pyrroloquinolinequinone-containing-dietary-formulation-on-motor-deficiency-cognitive-decline-and-mitochondrial-dysfunction-in-a-mouse-model-of-alzheimer-s-disease
#18
Darrell Sawmiller, Song Li, Takashi Mori, Ahsan Habib, David Rongo, Vedad Delic, Patrick C Bradshaw, R Douglas Shytle, Cyndy Sanberg, Paula Bickford, Jun Tan
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is linked to oxidative stress, altered amyloid precursor protein (APP) proteolysis, tau hyperphosphorylation and the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT). A growing body of evidence suggests that mitochondrial dysfunction can be a key promoter of all of these pathologies and predicts that restoration of mitochondrial function might be a potential therapeutic strategy for AD. Therefore, in the present study, we tested the beneficial effect of a nutraceutical formulation Nutrastem II (Nutra II), containing NT020 (a mitochondrial restorative and antioxidant proprietary formulation) and pyrroloquinolinequinone (PQQ, a stimulator of mitochondria biogenesis) in 5XFAD transgenic mice...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28409672/making-a-difference-a-study-of-cognitive-stimulation-therapy-for-persons-with-dementia
#19
Daniel B Stewart, Marla Berg-Weger, Susan Tebb, Michele Sakamoto, Kristina Roselle, Laura Downing, Janice Lundy, Deborah Hayden
Affecting nearly 5.4 million older adults in the United States and 35.6 million individuals worldwide, dementia is one of the greatest public health crises of our time. As a result, helping professionals, clients, and care partners seek effective and affordable treatment. Developed in the United Kingdom by Spector and colleagues, Cognitive Stimulation Therapy (CST) is a non-pharmacologic psychosocial group intervention for persons with dementia. To expand upon and fill the gaps within existing research, the authors developed a descriptive study to assess the impact of CST on cognition, quality of life, and depression, among six CST groups (n = 40)...
April 14, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28407970/a-simple-and-rapid-method-of-isolation-of-active-polypeptide-complex-yolkin-from-chicken-egg-yolk
#20
A Zambrowicz, A Zabłocka, Ł Bobak, J Macała, M Janusz, A Polanowski, T Trziszka
A large number of bioactive peptides isolated from natural sources are known to play important physiological roles in the human body. It is possible to use these as alternative therapy agents. One example is yolkin which can be useful as a food supplement, a natural therapeutic agent for preventing and treating cognitive disorders of various origins, preferably in patients with unsatisfactory responses to known therapies. A new simple method of isolation of yolkin based on precipitation with ethanol or acetone was developed...
September 1, 2017: Food Chemistry
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