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https://www.readbyqxmd.com/read/28086756/concomitant-disseminated-histoplasmosis-and-disseminated-tuberculosis-after-tumor-necrosis-factor-inhibitor-treatment-a-case-report
#1
Juan E Muñoz-Oca, Martha L Villarreal Morales, Aracelis Nieves-Rodriguez, Lemuel Martínez-Bonilla
BACKGROUND: Tumor necrosis factor antagonist inhibitors have transformed the approach to patients with severe autoimmune conditions, such as rheumatoid arthritis. Although the therapy can be highly effective, TNF-α inhibitors are associated with an increased risk of opportunistic infections. CASE PRESENTATION: Here, we report a case of concomitant disseminated histoplasmosis and tuberculosis in a 65-year-old female with rheumatoid arthritis treated with TNF-α inhibitor...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28076390/il-37-confers-protection-against-mycobacterial-infection-involving-suppressing-inflammation-and-modulating-t-cell-activation
#2
Haipeng Liu, Ruijuan Zheng, Peng Wang, Hua Yang, Xin He, Qun Ji, Wenjuan Bai, Hao Chen, Jianxia Chen, Wenxia Peng, Siyu Liu, Zhonghua Liu, Baoxue Ge
Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in the pathogenesis of tuberculosis (TB) has not been clearly elucidated. In this study, single nucleotide polymorphism (SNP) analysis demonstrated an association of the genetic variant rs3811047 of IL-37 with TB susceptibility. In line with previous report, a significant elevated IL-37 abundance in the sera and increased expression of IL-37 protein in the peripheral blood mononuclear cells (PBMC) were observed in TB patients in comparison to healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28069953/c-type-lectin-receptor-dcir-modulates-immunity-to-tuberculosis-by-sustaining-type-i-interferon-signaling-in-dendritic-cells
#3
Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A W Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Immune response against pathogens is a tightly regulated process that must ensure microbial control while preserving integrity of the infected organs. Tuberculosis (TB) is a paramount example of a chronic infection in which antimicrobial immunity is protective in the vast majority of infected individuals but can become detrimental if not finely tuned. Here, we report that C-type lectin dendritic cell (DC) immunoreceptor (DCIR), a key component in DC homeostasis, is required to modulate lung inflammation and bacterial burden in TB...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28069816/the-interaction-of-the-cd43-sialomucin-with-the-mycobacterium-tuberculosis-cpn60-2-chaperonin-mediates-macrophage-tnf-%C3%AE-production
#4
Alvaro Torres-Huerta, Tomas Villaseñor, Angel Flores-Alcantar, Cristina Parada, Estefanía Alemán-Navarro, Clara Espitia, Gustavo Pedraza-Alva, Yvonne Rosenstein
Mycobacterium tuberculosis is the causal agent of tuberculosis. TNF-α, TGF-β and IFN-γ secreted by activated macrophages and lymphocytes are considered essential to contain Mycobacterium tuberculosis infection. The CD43 sialomucin has been reported to act as a receptor for bacilli through its interaction with the chaperonin Cpn60.2, facilitating mycobacteria-macrophage contact. We report here that Cpn60.2 induces both THP-1 cells and bone marrow-derived macrophages (BMMs) to produce TNF-α and that this production is CD43 dependent...
January 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28061955/the-role-of-cd30-and-cd153-cd30l-in-the-anti-mycobacterial-immune-response
#5
REVIEW
Nancy D Marín, Luis F García
The establishment of a protective T-cell response against mycobacterial infections involves different co-stimulatory molecules and their respective ligands. Among these molecules the Tumor Necrosis Factor Receptor Super-family (TNFRSF) and the Tumor Necrosis Factor Super-family (TNFSF) are known to be important members. This review analyzes the evidence that CD30 and CD153 (CD30L), members of the TNFRSF and TNSF, play key roles in the T cell-dependent anti-mycobacterial immune response. Mice deficient in either CD30 or CD153, or treated with antibodies blocking the effects or CD30 and CD153, and infected with M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061954/multiple-cytokine-responses-in-discriminating-between-active-tuberculosis-and-latent-tuberculosis-infection
#6
Jing Wu, Sen Wang, Chanyi Lu, Lingyun Shao, Yan Gao, Zumo Zhou, Heqing Huang, Ying Zhang, Wenhong Zhang
BACKGROUND: Cytokines play an important role in cell-mediated immune responses against Mycobacterium tuberculosis (Mtb) infection. Cytokine profile specifically associated with active tuberculosis (ATB) patients, subjects with latent tuberculosis infection (LTBI) and non-infected individuals remains to be determined. METHODS: We enrolled a total of 92 subjects including patients with ATB (n = 25), LTBI (n = 36) and healthy controls (HC, n = 31) to investigate the cytokine production by peripheral blood mononuclear cells after Mtb purified protein derivative (PPD) stimulation which was evaluated by a beads-based multiplex assay system...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061952/anti-mycobacterial-function-of-macrophages-is-impaired-in-a-diet-induced-model-of-type-2-diabetes
#7
Md Abdul Alim, Suchandan Sikder, Tahnee L Bridson, Catherine M Rush, Brenda L Govan, Natkunam Ketheesan
Type 2 diabetes (T2D) is one of the major risk factors for tuberculosis (TB). In this study, a diet induced murine model of T2D (DIMT2D) was developed and characterized in the context of metabolic, biochemical and histopathological features following diet intervention. Mycobacterial susceptibility was investigated using Mycobacterium fortuitum as a surrogate. Phagocytic capability of alveolar macrophages and resident peritoneal macrophages were determined by in vitro assays using mycolic acid coated beads and M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061947/b-lymphocytes-forming-follicle-like-structures-in-the-lung-tissue-of-tuberculosis-infected-mice-dynamics-phenotypes-and-functional-activity
#8
Irina Linge, Alexander Dyatlov, Elena Kondratieva, Vadim Avdienko, Alexander Apt, Tatiana Kondratieva
During tuberculosis (TB) infection, B cells form follicles in close vicinity of lung granuloma. We assessed the dynamics of follicle formation, surface phenotypes and functional activity of lung B cells during TB course in genetically susceptible mice. The follicles appeared early post infection and peaked at weeks 7-8. Lung B cells resembled classical B2 cells (CD19(+)IgMloIgD(hi)CD1d(-)CD21/35(int)CD5(-)CD11b(-)CD43(-)), but differed from them by the absence of B2 marker CD23. Lung B-cells constitutively expressed MHC II molecules, presented mycobacterial antigens to immune CD4(+) T-cells and produced high amounts of IL-6 and IL-11, but no classical type 1 (TNF-α, IFN-γ), or anti-inflammatory (IL-10, TGF-β) cytokines...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28058501/-cytokine-neutralization-at-specific-cellular-source-a%C3%A2-new-therapeutic-paradigm-german-version
#9
A A Kruglov, S A Nedospasov
BACKGROUND: Currently, treatment of autoimmune diseases is based on manipulation of general control mechanisms, including those mediated by immunoregulatory cytokines. This approach is non-curative and may cause unwanted side effects due to numerous beneficial and non-redundant functions of a particular cytokine. METHODS: Techniques of reverse genetics, such as conditional gene targeting, were employed to uncover the contributions of two proinflammatory and immunomodulatory cytokines, tumour necrosis factor (TNF) and interleukin 6 (IL-6), in various disease states...
January 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28043584/increased-mycobacterium-tuberculosis-antigen-induced-gene-expression-of-interferon-gamma-tumor-necrosis-factor-alpha-and-interleukin-6-in-patients-with-diabetes
#10
Kiran I Masood, Muhammad Irfan, Qamar Masood, Bushra Jamil, Shoaib Rao, Maryam Rahim, Zahra Hasan
INTRODUCTION: Pakistan ranks fifth in high tuberculosis (TB)-burden countries and seventh among countries with high prevalence rates of diabetes mellitus (DM). DM is a risk factor for TB and worsens disease outcomes. Furthermore, Mycobacterium tuberculosis (MTB) infection can induce glucose intolerance and worsen glycemic control in diabetes. Suppressor of cytokine signaling (SOCS)-1 and -3 molecules regulate cytokine signaling and are important in maintaining an immune balance. In TB, interleukin (IL)-6 upregulation induces SOCS3, which is also a negative regulator of insulin signaling...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043513/modulation-of-cd4-and-cd8-response-to-quantiferon-tb-plus-in-patients-with-active-tuberculosis-and-latent-tuberculosis-infection-followed-over-time-during-treatment
#11
Teresa Chiacchio, Elisa Petruccioli, Ilaria Pepponi, Valentina Vanini, Gina Gualano, Daniela Cirillo, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti
OBJECTIVE/BACKGROUND: Interferon (IFN)-γ release assays (IGRA) are designed for diagnosing tuberculosis (TB) infection. The new IGRA, QuantiFERON-TB Plus (QFT-Plus), is based on the enzyme-linked immunosorbent assay detection of IFN-γ after stimulation with Mycobacterium tuberculosis TB1 and TB2 antigens. TB1 elicits a cellular-mediated immune (CMI) response by CD4 T cells, and TB2 contains peptides recognized by both CD4 and CD8 T cells. The aim of the study is to characterize the CMI to QFT-Plus peptides in active TB and latent TB infection (LTBI) at baseline and during or after specific treatment (follow-up)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043509/susceptibility-to-pulmonary-tuberculosis-host-genetic-deficiency-in-tumor-necrosis-factor-alpha-tnf-%C3%AE-gene-and-tumor-necrosis-factor-receptor-2-tnfr2
#12
Ehsan Ghamari, Poopak Farnia, Shima Saif, Mehran Marashian, Jaladein Ghanavi, Payam Tabarsi, Parissa Farnia, Ali Akbar Velayati
OBJECTIVE/BACKGROUND: The susceptibility to tuberculosis (TB) depends upon different factors, and the risk of developing diseases after infection with Mycobacterium tuberculosis ranges from 5% to 10%. This suggests that besides the mycobacterial itself, the host genetic factors may determine the differences in host susceptibility to TB. Among the important risk factors, cytokines and especially tumor necrosis factor alpha (TNF-α) genes, are thought to be responsible for regulating the protective immune responses...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28031119/-the-expression-of-t-bet-is-negatively-correlated-with-the-expressions-of-ifn-%C3%AE-and-tnf-%C3%AE-in-cd4-t-cells-of-patients-with-active-pulmonary-tuberculosis
#13
Bingfen Yang, Fei Zhai, Jing Jiang, Weiguo Sun, Ruo Wang, Hongjuan An, Xiaoxing Cheng
Objective To investigate the relationship between T box expressed in T cells (T-bet) and the production of interferon γ (IFN-γ), tumor necrosis factor α (TNF-α) and interleukin 2 (IL-2) in CD4(+)T cells of patients with active pulmonary tuberculosis. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from peripheral blood by density gradient centrifugation. Individuals with latent Mycobacterium tuberculosis (MTB) infection were screened by enzyme-linked immunospot assay (ELISPOT). The expressions of T-bet, IFN-γ, TNF-α and IL-2 in CD4(+)T cells were detected by flow cytometry...
January 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28007592/colostrum-proinflammatory-cytokines-as-biomarkers-of-bovine-immune-response-to-bovine-tuberculosis-btb
#14
Eduardo Sánchez-Soto, Rosa Ponce-Ramos, Rodolfo Hernández-Gutiérrez, Abel Gutiérrez-Ortega, Angel H Álvarez, Moisés Martínez-Velázquez, Angel E Absalón, Pablo Ortiz-Lazareno, Alberto Limón-Flores, Ciro Estrada-Chávez, Sara E Herrera-Rodríguez
Bovine colostrum contains compounds, which provide passive immune protection from mother to newborn calves. Little is known about cytokine levels and their role in bovine colostrum. Moreover, the capacity of bovine colostrum cells to mount specific immune responses after natural exposure to bovine tuberculosis (bTB) antigens in dairy herds has not been studied, thus far. The purpose of this study was to identify biomarkers for bTB infection measurable in bovine colostrum. The present study reveals that isolated-immune colostrum cells can mount a specific immune response against bTB antigens, by measuring the novo IFN-γ release in cell culture...
December 19, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28002150/screening-and-treatment-of-latent-tuberculosis-among-patients-receiving-biologic-agents-a-national-and-international-survey-of-rheumatologists
#15
Nhu Quynh Tran, Melinda Garcia-Rosell, Debendra Pattanaik, Syed Hasan Raza, Laura Carbone
OBJECTIVE: We sought to understand the current practice patterns of both US and international members of the American College of Rheumatology (ACR) in this regard. METHODS: A set of questionnaires developed by a focus group of faculties and fellows of the Rheumatology Division of University of Tennessee Health Science Center, Memphis, TN, was sent electronically using an online survey tool to 4433 rheumatologists who are ACR members in the United States and internationally...
January 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27997433/tuberculosis-screening-and-reactivation-among-a-national-cohort-of-patients-with-inflammatory-bowel-disease-treated-with-tumor-necrosis-factor-alpha-antagonists
#16
Jason K Hou, Jennifer R Kramer, Peter Richardson, Shubhada Sansgiry, Hashem B El-Serag
BACKGROUND: Tumor necrosis factor antagonists (anti-TNFs) are effective in treating inflammatory bowel disease (IBD) but may cause reactivation of tuberculosis (TB). TB screening rates and related outcomes are not well described among patients with IBD. This study aims to evaluate the prevalence and determinants of TB screening before anti-TNF initiation and related outcomes among patients with IBD. METHODS: We identified patients with IBD with filled prescriptions for anti-TNFs using the National Veterans Affairs administrative data sets...
December 16, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27995986/persistent-p55tnfr-expression-impairs-t-cell-responses-during-chronic-tuberculosis-and-promotes-reactivation
#17
Ivy M Dambuza, Roanne Keeton, Nai-Jen Hsu, Nasiema Allie, Valérie F J Quesniaux, Bernhard Ryffel, Muazzam Jacobs
The pleiotropic activities of TNF are mediated by two structurally related but functionally distinct type I transmembrane receptors, p55TNFR and p75TNFR expressed in most cell types, that can be cleaved and act as TNF scavengers. Here, we investigated the effect of persistent p55TNFR cell surface expression during aerosol inhalation challenge with virulent M. tuberculosis H37Rv. We demonstrated that persistency of p55TNFR in macrophage cultures increased the synthesis of soluble TNF, p75TNFR and NO, however, had no effects on bacteria killing ability...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27990383/biologics-use-in-indian-psoriasis-patients
#18
Murlidhar Rajagopalan, Asit Mital
The biologics currently in use for psoriasis in India are etanercept, infliximab and recently introduced itolizumab and secukinumab. Biosimilars, expected to play a significant role in psoriasis management in future, have also been available for the last few years. Patients with psoriasis may be considered eligible to receive treatment with any of the licensed biologic interventions when they fulfill the eligibility criteria. The decision to proceed with treatment must be made in collaboration with the patient and include a careful assessment of the associated risks and benefits...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27980775/involvement-of-il-17a-producing-tcr-%C3%AE-%C3%AE-t-cells-in-late-protective-immunity-against-pulmonary-mycobacterium-tuberculosis-infection
#19
Masayuki Umemura, Yuko Okamoto-Yoshida, Ayano Yahagi, Seigo Touyama, Susumu Nakae, Yoichiro Iwakura, Goro Matsuzaki
INTRODUCTION: Interleukin (IL)-17A is a cytokine originally reported to induce neutrophil-mediated inflammation and anti-microbial activity. The CD4(+) T cells, which produce IL-17A, have been well characterized as Th17 cells. On the other hand, IL-17A-producing TCR γδ(+) T cells have been reported to participate in the immune response at an early stage of infection with Listeria monocytogenes and Mycobacterium bovis in mice. However, the involvement of IL-17A in protective immunity was not clearly demonstrated in the chronic stage of M...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27965663/alteration-in-the-gut-microbiota-provokes-susceptibility-to-tuberculosis
#20
Nargis Khan, Aurobind Vidyarthi, Sajid Nadeem, Shikha Negi, Girish Nair, Javed N Agrewala
The microbiota that resides in the gastrointestinal tract provides essential health benefits to the host. In particular, they regulate immune homeostasis. Recently, several evidences indicate that alteration in the gut microbial community can cause infectious and non-infectious diseases. Tuberculosis (TB) is the most devastating disease, inflicting mortality and morbidity. It remains unexplored, whether changes in the gut microbiota can provoke or prevent TB. In the current study, we have demonstrated the antibiotics driven changes in the gut microbial composition and their impact on the survival of Mycobacterium tuberculosis (Mtb) in the lungs, liver, and spleen of infected mice, compared to those with intact microbiota...
2016: Frontiers in Immunology
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