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https://www.readbyqxmd.com/read/29235156/ifn-%C3%AE-against-the-38-kda-antigen-of-mycobacterium-tuberculosis-discriminates-pulmonary-tuberculosis-from-infection-and-infection-from-exposure-evidence-from-a-study-of-human-population-in-a-high-endemic-setting
#1
Fekadu Abebe, Mulugeta Belay, Mengistu Legesse
Mycobacterium tuberculosis (Mtb) 38-kDa antigen is an immunogenic lipoprotein that induces strong T-cell responses in experimental animals. However, there is limited information on the role of this antigen in human population. In this article, we present the dynamics of pro-inflammatory (IFN-γ and TNF-α) and anti-inflammatory cytokine (IL-10) against the 38 kDa in cohorts of pulmonary TB (PTB) patients, household contacts (HHCs), and community controls (CCs) in a high endemic setting. Whole blood assay was used to determine the levels of cytokines in 149 patients, 149 HHCs, and 68 CCs at baseline, 6 months, and 12 months...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29230224/lipoarabinomannan-decreases-galectin-9-expression-and-tumor-necrosis-factor-pathway-in-macrophages-favoring-mycobacterium-tuberculosis-intracellular-growth
#2
Leslie Chávez-Galán, Lucero Ramon-Luing, Claudia Carranza, Irene Garcia, Isabel Sada-Ovalle
Lipoarabinomannan (LAM) is a lipid virulent factor secreted by Mycobacterium tuberculosis (Mtb). LAM can be found in the sputum and urine of patients with active tuberculosis. When human monocytes are differentiated into macrophages [monocyte-derived macrophages (MDM)] in the presence of LAM, MDM are poorly functional which may limit the immune response to Mtb infection. Our previous studies have shown that TIM3 and galectin (GAL)9 interaction induces anti-mycobacterial activity, and the expression levels of TIM3 and GAL9 are downregulated during Mtb infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29208761/priming-of-innate-antimycobacterial-immunity-by-heat-killed-listeria-monocytogenes-induces-sterilizing-response-in-the-adult-zebrafish-tuberculosis-model
#3
Hanna Luukinen, Milka Marjut Hammarén, Leena-Maija Vanha-Aho, Aleksandra Svorjova, Laura Kantanen, Sampsa Järvinen, Bruno Vincent Luukinen, Eric Dufour, Mika Rämet, Vesa Pekka Hytönen, Mataleena Parikka
Mycobacterium tuberculosis remains one of the most problematic infectious agents due to its highly developed mechanisms to evade host immune responses combined with the increasing emergence of antibiotic resistance. Host-directed therapies aiming at optimal modulation of immune responses to improve bacterial eradication or to limit excessive inflammation are a new strategy for the treatment of tuberculosis. In this study, we have established a zebrafish-Mycobacterium marinum natural host-pathogen model system to study induced protective immune responses in mycobacterial infection...
November 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29198746/valproic-acid-attenuates-inflammation-of-optic-nerve-and-apoptosis-of-retinal-ganglion-cells-in-a-rat-model-of-optic-neuritis
#4
Qiang Liu, Haining Li, Juan Yang, Xiaoyan Niu, Chunmei Zhao, Li Zhao, Zhenhai Wang
AIMS: Optic neuritis (ON) is an inflammatory disease of the optic nerve, which often occurs in patients with multiple sclerosis (MS) and leads to retinal ganglion cell (RGC) death and even severe visual loss. Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects. Here, we examined the effects of VPA in experimental autoimmune encephalomyelitis (EAE) rats and explored the underlying mechanisms. MAIN METHODS: EAE was induced by subcutaneous injection with myelin basic protein, emulsified with complete Freund's adjuvant and Mycobacterium tuberculosis H37Ra into the Lewis rats...
November 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29197526/pathway-analysis-of-differentially-expressed-genes-in-mycobacterium-bovis-challenged-bovine-macrophages
#5
Sanjeev Kumar Shukla, Shubhra Shukla, Anuj Chauhan, Sarvjeet, Rehan Khan, Anuj Ahuja, Lakshya Veer Singh, Nitin M Kamble, Anupam Dhasmana, Naveen Sharma, Bipin Chand, Ajay Vir Singh, Manjit Panigrahi
The immune signalling genes during challenge of bovine macrophages with bacterial products derived from disease causing bacteria in cattle were investigated. An in-vitro cell culture model were challenged to Mycobacterium bovis of bovine monocyte derived macrophages. Macrophages from healthy and already infected animals can both be fully activated during M. bovis infection. Analysis of mRNA abundance in peripheral blood mononuclear cells from M. bovis infected and non-infected cattle were performed as a controls...
November 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29189980/patients-with-type-1-diabetes-mellitus-have-impaired-il-1%C3%AE-production-in-response-to-mycobacterium-tuberculosis
#6
E Lachmandas, K Thiem, C van den Heuvel, A Hijmans, B E de Galan, C J Tack, M G Netea, R van Crevel, J A van Diepen
Patients with diabetes mellitus have an increased risk of developing tuberculosis. Although the underlying mechanism is unclear, evidence suggests a role for chronic hyperglycaemia. We examined the influence of hyperglycaemia on Mycobacterium tuberculosis-induced cytokine responses in patients with type 1 diabetes mellitus (T1D). Peripheral blood mononuclear cells (PBMCs) from 24 male T1D patients with sub-optimal glucose control [HbA1c > 7.0% (53 mmol/L)] and from 24 age-matched male healthy controls were stimulated with M...
November 30, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29184553/tumor-necrosis-factor-alpha-targeting-can-protect-against-arthritis-with-low-sensitization-to-infection
#7
Nadia Belmellat, Luca Semerano, Noria Segueni, Diane Damotte, Patrice Decker, Bernhard Ryffel, Valérie Quesniaux, Marie-Christophe Boissier, Eric Assier
Tumor necrosis factor-alpha (TNF-α) blockade is an effective treatment for rheumatoid arthritis (RA) and other inflammatory diseases, but in patients, it is associated with reduced resistance to the infectious agents Mycobacterium tuberculosis and Listeria monocytogenes, among others. Our goal was to model infection and arthritis in mice and to compare etanercept, a currently used anti-TNF-α inhibitor, to an anti-TNF-α vaccine. We developed a murine surrogate of the TNF-α kinoid and produced an anti-murine TNF-α vaccine (TNFKi) composed of keyhole limpet hemocyanin conjugated to TNF-α, which resulted in anti-TNF-α antibody production in mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29180322/-peripheral-blood-t-cell-tnf-%C3%AE-and-ifn-%C3%AE-production-stimulated-by-low-molecular-peptide-of-mycobacterium-tuberculosis-heat-resistant-antigen-for-differential-diagnosis-between-pulmonary-tuberculosis-and-latent-tuberculosis-infection
#8
Jie Tang, Ce Chen, Cheng Zha, Jian-Rong Chang, Qiang Fang, Zhao-Hua Wang, Bai-Qing Li
OBJECTIVE: To investigate the effects of low molecular peptide of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg-10k) on the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood T cells and test the feasibility of differential diagnosis between pulmonary tuberculosis (PTB) and latent tuberculosis infection (LTBI) by assessing the number of Mtb-HAg-10k-stimulated IFN-γ-producing T cells. METHODS: Peripheral blood mononuclear cells (PBMCs) were separated from the peripheral blood of 10 healthy adults, 6 individuals with LTBI and 13 patients with PTB...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29175527/factors-that-contribute-to-indeterminate-results-from-the-quantiferon-tb-gold-in-tube-test-in-patients-with-inflammatory-bowel-disease
#9
Manreet Kaur, Prianka Singapura, Neeharika Kalakota, Guillermina Cruz, Richa Shukla, Sidra Ahsan, Aylin Tansel, Aaron P Thrift, Hashem B El-Serag
BACKGROUND & AIMS: The QuantiFERON-tuberculosis gold in-tube (QFT-GIT) test is widely used to screen for latent Mycobacterium tuberculosis infection in patients with inflammatory bowel diseases (IBD) before treatment with a tumor necrosis factor antagonist. The test frequently produces indeterminate results, prompting additional testing. We evaluated factors associated with indeterminate results from the QTF-GIT test among patients with IBD. METHODS: We conducted a case-control study among eligible adults with QTF-GIT test results and a concomitant diagnosis of IBD receiving care at a tertiary referral center from 2011 through 2013...
November 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#10
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29150737/risk-of-active-tuberculosis-in-patients-with-inflammatory-arthritis-receiving-tnf-inhibitors-a-look-beyond-the-baseline-tuberculosis-screening-protocol
#11
Alina Soare, Ana Maria Gheorghiu, Victoria Aramă, Dragoș Bumbăcea, Rucsandra Dobrotă, Raida Oneaţă, Simona Pintilie, Mihaela Milicescu, Ioan Ancuţa, Andrei Martin, Mariana Sasu, Claudia Ciofu, Liviu Macovei, Victor Stoica, Mihai Bojincă, Carina Mihai
Tuberculosis (TB) is a major concern in patients receiving TNF inhibitors (TNFi). This study aimed to assess the incidence of active TB and the efficacy of TB prevention measures used over the years, and to determine risk factors for developing TB, in a single-centre cohort of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) receiving TNFi. Data of all patients in whom treatment with TNFi was initiated in our rheumatology clinic until December 1st 2014 have been retrospectively analysed...
November 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29142521/fatal-infections-in-older-patients-with-inflammatory-bowel-disease-on-anti-tumor-necrosis-factor-therapy
#12
Way-Seah Lee, Najib Azmi, Ruey-Terng Ng, Sik-Yong Ong, Sasheela Sri La Ponnampalavanar, Sanjiv Mahadeva, Ida Hilmi
Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29134265/deletion-of-the-%C3%AE-propeller-protein-gene-rv1057-reduces-esat-6-secretion-and-intracellular-growth-of-mycobacterium-tuberculosis
#13
Jiafang Fu, Gongli Zong, Peipei Zhang, Yuanxin Gu, Guangxiang Cao
Rv1057 is the only β-propeller protein in Mycobacterium tuberculosis, but its biological function is still unclear. In this study, we generated a deletion mutant of Rv1057 (D1057) in the virulent M. tuberculosis strain H37Rv and examined the characteristics of the mutant in vitro and in macrophages. We found that deletion of Rv1057 reduces secretion of the major virulence factor ESAT-6 and ESAT-6 stops in the cell envelope fraction during secretion, although ESAT-6 levels were similar in lysates of the mutant and control strains...
November 13, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29131034/clinical-trial-and-registry-data
#14
Melinda Gooderham, Kim Papp
Physicians rely on safety and efficacy data from pivotal trials to guide treatment decisions and manage patients. Even with robust clinical trial data, there remain questions regarding rare safety events and generalizability. Registries complement clinical trials. By evaluating effectiveness and safety in broad patient populations and often providing longer term or larger numbers of patients or both compared to clinical trials, registries consolidate and may extend the safety observations derived from pivotal trials...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29121953/risk-of-tuberculosis-among-alabama-children-and-adolescents-treated-with-tumor-necrosis-factor-inhibitors-a-retrospective-study
#15
Matthew L Stoll, James Aaron Grubbs, Timothy Beukelman, Melissa L Mannion, Traci W Jester, Randy Q Cron, Marilyn J Crain
BACKGROUND: Tumor Necrosis Factor inhibitors (TNFi) have dramatically improved the outlook for patients with inflammatory arthritides and bowel disease (IBD), but are associated with increased infection risks, including tuberculosis (TB). Pediatric inflammatory diseases are uncommon, and the risk of TB in children taking TNFi remains unclear. The objective of this study was to report the incidence of TB disease among TNFi recipients at a single pediatric medical center serving most of Alabama compared to that of the general population of Alabama children...
November 9, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29119581/risk-of-tuberculosis-comparison-in-new-users-of-antitumour-necrosis-factor-%C3%AE-and-with-existing-disease-modifying-antirheumatic-drug-therapy
#16
M-J Chan, Y-H Wen, Y-B Huang, H-Y Chuang, Y-L Tain, Y-C Lily Wang, C-N Hsu
WHAT IS KNOWN AND OBJECTIVE: Patients with rheumatic disease are at risk for infections. Evaluating antitumour necrosis factor (anti-TNF) drug-associated risk of infections requires justification of baseline risk in the population at high risk of infection. We examined the incidence of active tuberculosis (TB) and its risk factors in patients with rheumatic disease started with anti-TNF-α therapy or with existing disease-modifying antirheumatic drug (DMARD) therapy. METHODS: A retrospective cohort study of anti-TNF-α therapy new users (anti-TNF-α group) and those starting with a DMARD after the failure of at least one other DMARD or who had added to existing DMARD treatment (DMARD group) for rheumatic disease in the largest medical setting in Taiwan from 1 January 2005 through 31 November 2013 was conducted to determine relative risk of TB between patient groups...
November 8, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29106984/evaluation-of-profile-and-functionality-of-memory-t-cells-in-pulmonary-tuberculosis
#17
Marcela M Tonaco, Jôsimar D Moreira, Fernanda F C Nunes, Cristina M G Loures, Larissa R Souza, Janaina M Martins, Henrique R Silva, Arthur Henrique R Porto, Vicente Paulo C P Toledo, Silvana S Miranda, Tânia Mara P D Guimarães
The cells T CD4+ T and CD8+ can be subdivided into phenotypes naïve, T of central memory, T of effector memory and effector, according to the expression of surface molecules CD45RO and CD27. The T lymphocytes are cells of long life with capacity of rapid expansion and function, after a new antigenic exposure. In tuberculosis, it was found that specific memory T cells are present, however, gaps remain about the role of such cells in the disease immunology. In this study, the phenotypic profile was analyzed and characterized the functionality of CD4+ T lymphocytes and CD8+ T cells of memory and effector, in response to specific stimuli in vitro, in patients with active pulmonary TB, compared to individuals with latent infection with Mycobacterium tuberculosis the ones treated with pulmonary TB...
December 2017: Immunology Letters
https://www.readbyqxmd.com/read/29101404/autoreactive-t-cells-in-immunopathogenesis-of-tb-associated-uveitis
#18
Ravichandra Tagirasa, Shaifaly Parmar, Manas R Barik, Satish Devadas, Soumyava Basu
Purpose: Intraocular inflammation in tuberculosis-associated uveitis (TBU) is usually widespread, and responds unpredictably to treatment. Herein, we analyze the intraocular T-cell response in TBU for its surface phenotype, antigenic specificity, and functional characteristics to explain the above observations. Methods: We isolated T cells from vitreous humor samples of patients with TBU and non-TB uveitis (controls). These were directly stained for surface markers CD4, CD8, CD45RO, CD45RA, CCR7, as well as intracellular cytokines IFN-γ, TNF-α, and IL-17 and analyzed on flow cytometry...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29096637/purification-of-target-proteins-from-intracellular-inclusions-mediated-by-intein-cleavable-polyhydroxyalkanoate-synthase-fusions
#19
Jinping Du, Bernd H A Rehm
BACKGROUND: Recombinant protein production and purification from Escherichia coli is often accompanied with expensive and complicated procedures, especially for therapeutic proteins. Here it was demonstrated that, by using an intein cleavable polyhydroxyalkanoate synthase fusion, recombinant proteins can be first produced and sequestered on a natural resin, the polyhydroxyalkanoate (PHA) inclusions, then separated from contaminating host proteins via simple PHA bead isolation steps, and finally purified by specific release into the soluble fraction induced by a pH reduction...
November 2, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29090221/ifn-%C3%AE-boosting-of-mycobacterium-bovis-bacillus-calmette-g%C3%A3-erin-vaccine-promoted-th1-type-cellular-response-and-protection-against-m-tuberculosis-infection
#20
C E Rivas-Santiago, G G Guerrero
The role of type I IFNs in the pathogenesis and control of mycobacterial infection is still controversial. It has been reported that type I IFNs exacerbated M. tuberculosis infection through hampering Th1 type cellular immune response. However, under certain conditions they can act as natural immune adjuvants for commercial vaccines. At this point, we have reported recently that successive IFN-alpha boosting of Mycobacterium bovis Bacillus Calmette Güerin (BCG) vaccinated mice protected adult mice from intradermal M...
2017: BioMed Research International
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