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https://www.readbyqxmd.com/read/28454482/effects-of-environmental-factors-and-metallic-electrodes-on-ac-electrical-conduction-through-dna-molecule
#1
S Abdalla, A Obaid, F M Al-Marzouki
BACKGROUND: Deoxyribonucleic acid (DNA) is one of the best candidate materials for various device applications such as in electrodes for rechargeable batteries, biosensors, molecular electronics, medical- and biomedical-applications etc. Hence, it is worthwhile to examine the mechanism of charge transport in the DNA molecule, however, still a question without a clear answer is DNA a molecular conducting material (wire), semiconductor, or insulator? The answer, after the published data, is still ambiguous without any confirmed and clear scientific answer...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454355/what-is-known-about-melatonin-chemotherapy-and-altered-gene-expression-in-breast-cancer
#2
Carlos Martínez-Campa, Javier Menéndez-Menéndez, Carolina Alonso-González, Alicia González, Virginia Álvarez-García, Samuel Cos
Melatonin, synthesized in and released from the pineal gland, has been demonstrated by multiple in vivo and in vitro studies to have an oncostatic role in hormone-dependent tumors. Furthermore, several clinical trials point to melatonin as a promising adjuvant molecule to be considered for cancer treatment. In the past few years, evidence of a broader spectrum of action of melatonin as an antitumor agent has arisen; thus, melatonin appears to also have therapeutic effects in several types of hormone-independent cancer, including ovarian, leukemic, pancreatic, gastric and non-small cell lung carcinoma...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454071/increased-gait-variability-may-not-imply-impaired-stride-to-stride-control-of-walking-in-healthy-older-adults-winner-2013-gait-and-clinical-movement-analysis-society-best-paper-award
#3
Jonathan B Dingwell, Mandy M Salinas, Joseph P Cusumano
Older adults exhibit increased gait variability that is associated with fall history and predicts future falls. It is not known to what extent this increased variability results from increased physiological noise versus a decreased ability to regulate walking movements. To "walk", a person must move a finite distance in finite time, making stride length (Ln) and time (Tn) the fundamental stride variables to define forward walking. Multiple age-related physiological changes increase neuromotor noise, increasing gait variability...
March 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28453970/on-chip-ultrasonic-manipulation-of-microparticles-by-using-the-flexural-vibration-of-a-glass-substrate
#4
Ryota Yamamoto, Daisuke Koyama, Mami Matsukawa
As biotechnology develops, techniques for manipulating and separating small particles such as cells and DNA are required in the life sciences. This paper investigates on-chip manipulation of microparticles in small channels by using ultrasonic vibration. The chip consists of a rectangular glass substrate with a cross-shaped channel (cross-section: 2.0×2.0mm(2)) and four lead zirconate titanate transducers attached to the substrate's four corners. To efficiently generate the flexural vibration mode on the chip, we used finite element analysis to optimize the configurations of the glass substrate and transducers...
December 15, 2016: Ultrasonics
https://www.readbyqxmd.com/read/28453712/use-of-performance-metrics-for-the-measurement-of-universal-coverage-for-maternal-care-in-mexico
#5
Edson Serván-Mori, David Contreras-Loya, Octavio Gomez-Dantés, Gustavo Nigenda, Sandra G Sosa-Rubí, Rafael Lozano
This study provides evidence for those working in the maternal health metrics and health system performance fields, as well as those interested in achieving universal and effective health care coverage. Based on the perspective of continuity of health care and applying quasi-experimental methods to analyse the cross-sectional 2009 National Demographic Dynamics Survey (n = 14 414 women), we estimated the middle-term effects of Mexico's new public health insurance scheme, Seguro Popular de Salud (SPS) (vs women without health insurance) on seven indicators related to maternal health care (according to official guidelines): (a) access to skilled antenatal care (ANC); (b) timely ANC; (c) frequent ANC; (d) adequate content of ANC; (e) institutional delivery; (f) postnatal consultation and (g) access to standardized comprehensive antenatal and postnatal care (or the intersection of the seven process indicators)...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453637/automated-identification-of-implausible-values-in-growth-data-from-pediatric-electronic-health-records
#6
Carrie Daymont, Michelle E Ross, A Russell Localio, Alexander G Fiks, Richard C Wasserman, Robert W Grundmeier
Objective: Large electronic health record (EHR) datasets are increasingly used to facilitate research on growth, but measurement and recording errors can lead to biased results. We developed and tested an automated method for identifying implausible values in pediatric EHR growth data. Materials and Methods: Using deidentified data from 46 primary care sites, we developed an algorithm to identify weight and height values that should be excluded from analysis, including implausible values and values that were recorded repeatedly without remeasurement...
April 26, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28449427/trichuris-trichiura-infection-in-north-korean-defector-resulted-in-chronic-abdominal-pain-and-growth-retardation
#7
Jong Bin Kim, Kwang Il Seo, Won Moon
Trichuris trichiura infection is a common helminth infection, which is transmitted via soil, with worldwide distribution, especially in rural areas of developing countries. Occasionally, sporadic cases occur in non-endemic, developed areas due to the widespread of immigration. We experienced a case of Trichuris dysentery syndrome in a young North Korean defector, who had been suffering from chronic abdominal pain for 10 years. He is relatively short and thin compared with his older brother. Unexpectedly, the diagnosis, made by a colonoscopy, revealed numerous, small, white, and gently moving worms at the cecum and ascending colon...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449415/socioeconomic-determinants-of-growth-in-a-longitudinal-study-in-nepal
#8
Delan Devakumar, Dalvir Kular, Bhim P Shrestha, Carlos Grijalva-Eternod, Rhian M Daniel, Naomi M Saville, Dharma S Manandhar, Anthony Costello, David Osrin, Jonathan C K Wells
Socioeconomic status (SES) is associated with childhood anthropometry, but little is known about how it is associated with tissue growth and body composition. To investigate this, we looked at components of SES at birth with growth in early and mid-childhood, and body composition in a longitudinal study in Nepal. The exposure variables (material assets, land ownership, and maternal education) were quantified from questionnaire data before birth. Anthropometry data at birth, 2.5 and 8.5 years, were normalized using WHO reference ranges and conditional growth calculated...
April 27, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28449366/moving-forward-with-the-neuromuscular-junction
#9
REVIEW
Claire Legay, Lin Mei
The neuromuscular junction (NMJ) is indispensable for survival. This synapse between motoneurons and skeletal muscle fibers allows posture, movement and respiration. Therefore, its dysfunction creates pathologies than can be lethal. The molecular mechanisms of NMJ development and maintenance are the subject of intensive studies. This mini-review focuses on some of the most recent discoveries. An unexpected role for a protein, rapsyn, which has been known for 40 years to aggregate acetylcholine receptors has emerged...
April 27, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28449323/in-vitro-comparison-of-renal-stone-laser-treatment-using-fragmentation-and-popcorn-technique
#10
Paul Klaver, Tjeerd de Boorder, Alex I Rem, Tycho M T W Lock, Herke Jan Noordmans
OBJECTIVE: To study the effectiveness of two laser techniques clinically used to fragment renal stones: fragmenting technique (FT) and popcorn technique (PT). METHODS: Phantom stones were placed in a test tube filled with water, mimicking a renal calyx model. A Holmium:YAG laser was used for fragmentation using both techniques. Four series of experiments were performed with two parameters: the technique (FT or PT) and the number of stones in the test tube (one or four)...
April 27, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28449097/creating-a-culture-of-collaboration-a-brief-history-of-academic-neurosurgery-in-washington-dc
#11
Alan Siu, Christopher J Neal, Hasan R Syed, Daniel R Felbaum, M Nathan Nair, Kevin M McGrail, Anthony J Caputy, Donald C Shields
Clinical neurosurgery has been practiced in the US capital for just over 100 years. As former residents and fellows of Drs. Harvey Cushing and Walter Dandy moved to the region, hospitals at Georgetown and George Washington Universities became early adopters of this new surgical discipline. Later academic neurosurgery programs were established at the National Institutes of Health, Walter Reed Medical Center, and Children's National Medical Center. Neurosurgical pioneers at these institutions developed new technologies and diagnostic procedures which continue to inform our current practice...
April 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28448966/peritoneal-dialysis-as-the-dialysis-initial-modality-of-choice-for-renal-replacement-therapy-initiation-moving-from-why-to-why-not
#12
Srinivas Subramanian, Muhammad Masoom Javaid
No abstract text is available yet for this article.
April 28, 2017: Blood Purification
https://www.readbyqxmd.com/read/28448923/impacts-of-himalayas-on-black-carbon-over-the-tibetan-plateau-during-summer-monsoon
#13
Shuyu Zhao, Xuexi Tie, Xin Long, Junji Cao
The Tibetan Plateau (TP) plays important roles in global climate and environment. This study combines in-situ BC measurements in the Himalayas and the Indo-Gangetic Plain (IGP) with a regional dynamical and chemical model (WRF-Chem model) to investigate the effect of the trans-Himalayas on black carbon (BC) from the IGP to the TP during Indian summer monsoon. To determine topographic effects of the trans-Himalayas on BC concentrations over the TP, sensitive experiments were conducted by applying the WRF-Chem model...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448832/fabrication-of-a-novel-z-scheme-g-c3n4-bi4o7-heterojunction-photocatalyst-with-enhanced-visible-light-driven-activity-toward-organic-pollutants
#14
Meng Sun, Yu Wang, Yu Shao, Yunhui He, Qi Zeng, Huikai Liang, Tao Yan, Bin Du
In this work, highly efficient g-C3N4/Bi4O7 heterojunction photocatalysts have been successfully fabricated by a facile method. Compared with the bare photocatalysts, the obtained g-C3N4/Bi4O7 hybrid photocatalysts exhibited efficient degradation activity toward methylene blue (MB), phenol, rhodamine B (RhB), and bisphenol A (BPA) under visible light irradiation. The influences of different g-C3N4 contents on the photocatalytic efficiency of the hybrid photocatalysts have been investigated. The results revealed that the g-C3N4/Bi4O7 with g-C3N4 mass ratio of 30% exhibited the best photocatalytic activity...
April 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448782/amcp-partnership-forum-driving-value-and-outcomes-in-oncology
#15
(no author information available yet)
Innovation in cancer treatment has provided a wealth of recently available therapeutic agents and a healthy drug pipeline that promises to change the way we approach this disease and the lives of those affected in the years to come. However, the majority of these new agents, many of which are targeted to specific genomic features of various tumors, may challenge the health care system's ability to afford cancer care. This innovation drives the need to focus on the value of the treatments provided to patients with cancer and on methods to optimize the efficiency of the dollars we spend, in addition to the clinical value itself...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448667/association-between-facial-rejuvenation-and-observer-ratings-of-youth-attractiveness-success-and-health
#16
Kristin L Bater, Lisa E Ishii, Ira D Papel, Theda C Kontis, Patrick J Byrne, Kofi D O Boahene, Jason C Nellis, Masaru Ishii
Importance: Surgical procedures for the aging face-including face-lift, blepharoplasty, and brow-lift-consistently rank among the most popular cosmetic services sought by patients. Although these surgical procedures are broadly classified as procedures that restore a youthful appearance, they may improve societal perceptions of attractiveness, success, and health, conferring an even larger social benefit than just restoring a youthful appearance to the face. Objectives: To determine if face-lift and upper facial rejuvenation surgery improve observer ratings of age, attractiveness, success, and health and to quantify the effect of facial rejuvenation surgery on each individual domain...
April 27, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28448464/bayesian-device-free-localization-and-tracking-in-a-binary-rf-sensor-network
#17
Zhenghuan Wang, Heng Liu, Shengxin Xu, Xiangyuan Bu, Jianping An
Received-signal-strength-based (RSS-based) device-free localization (DFL) is a promising technique since it is able to localize the person without attaching any electronic device. This technology requires measuring the RSS of all links in the network constituted by several radio frequency (RF) sensors. It is an energy-intensive task, especially when the RF sensors work in traditional work mode, in which the sensors directly send raw RSS measurements of all links to a base station (BS). The traditional work mode is unfavorable for the power constrained RF sensors because the amount of data delivery increases dramatically as the number of sensors grows...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28448053/automated-contraction-analysis-of-human-engineered-heart-tissue-for-cardiac-drug-safety-screening
#18
Ingra Mannhardt, Umber Saleem, Anika Benzin, Thomas Schulze, Birgit Klampe, Thomas Eschenhagen, Arne Hansen
Cardiac tissue engineering describes techniques to constitute three dimensional force-generating engineered tissues. For the implementation of these procedures in basic research and preclinical drug development, it is important to develop protocols for automated generation and analysis under standardized conditions. Here, we present a technique to generate engineered heart tissue (EHT) from cardiomyocytes of different species (rat, mouse, human). The technique relies on the assembly of a fibrin-gel containing dissociated cardiomyocytes between elastic polydimethylsiloxane (PDMS) posts in a 24-well format...
April 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28448013/precision-cut-mouse-lung-slices-to-visualize-live-pulmonary-dendritic-cells
#19
Miranda R Lyons-Cohen, Seddon Y Thomas, Donald N Cook, Hideki Nakano
Inhalation of allergens and pathogens elicits multiple changes in a variety of immune cell types in the lung. Flow cytometry is a powerful technique for quantitative analysis of cell surface proteins on immune cells, but it provides no information on the localization and migration patterns of these cells within the lung. Similarly, chemotaxis assays can be performed to study the potential of cells to respond to chemotactic factors in vitro, but these assays do not reproduce the complex environment of the intact lung...
April 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447985/methods-for-the-self-integration-of-megamolecular-biopolymers-on-the-drying-air-lc-interface
#20
Kosuke Okeyoshi, Kensuke Osada, Maiko K Okajima, Tatsuo Kaneko
Living organisms that use water are always prone to drying in the environment. Their activities are driven by biopolymer-based micro- and macro-structures, as seen in the cases of moving water in vascular bundles and moisturizing water in skin layers. In this study, we developed a method for assessing the effect of aqueous liquid crystalline (LC) solutions composed of biopolymers on drying. As LC biopolymers have megamolecular weight, we chose to study polysaccharides, cytoskeletal proteins, and DNA. The observation of biopolymer solutions during drying under polarized light reveals milliscale self-integration starting from the unstable air-LC interface...
April 7, 2017: Journal of Visualized Experiments: JoVE
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