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https://www.readbyqxmd.com/read/29151108/a-phenomenological-account-of-sensorimotor-difficulties-in-autism-intentionality-movement-and-proprioception
#1
Till D A Grohmann
During the last decades, the focus in autism research has been progressively extended. Today it offers a large amount of material on sensorimotor disturbances as well as perceptive-cognitive preferences of people with autism. However, there are more and more critical voices against an intellectualist perspective in the cognitive sciences. The "enactive approach" as well as a new "movement perspective" to autism challenge the view of autism as a mere "cognitive" disturbance. They criticize the conception of a cognizing subject which is only interested in the world in as much as she/he can extract knowledge and organize it rationally...
November 18, 2017: Psychopathology
https://www.readbyqxmd.com/read/29150767/cell-migration-in-1d-and-2d-nanofiber-microenvironments
#2
Horacio M Estabridis, Aniket Jana, Amrinder Nain, David J Odde
Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber orientation and network geometry influence cell movement. Here we describe a quantitative, modeling-based approach toward identifying the mechanisms by which cells migrate in fibrous geometries having well controlled orientation. Specifically, U251 glioblastoma cells were seeded onto non-electrospinning Spinneret based tunable engineering parameters fiber substrates that consist of networks of suspended 400 nm diameter nanofibers...
November 17, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29150602/tlr7-mediated-viral-recognition-results-in-focal-type-i-interferon-secretion-by-dendritic-cells
#3
Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Plasmacytoid dendritic cells (pDC) sense viral RNA through toll-like receptor 7 (TLR7), form self-adhesive pDC-pDC clusters, and produce type I interferons. This cell adhesion enhances type I interferon production, but little is known about the underlying mechanisms. Here we show that MyD88-dependent TLR7 signaling activates CD11a/CD18 integrin to induce microtubule elongation. TLR7(+) lysosomes then become linked with these microtubules through the GTPase Arl8b and its effector SKIP/Plekhm2, resulting in perinuclear to peripheral relocalization of TLR7...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29150087/dexmedetomidine-methadone-ketamine-versus-dexmedetomidine-methadone-alfaxalone-for-cats-undergoing-ovariectomy
#4
Rocio Fernandez-Parra, Chiara Adami, Thomas Dresco, Thomas M Donnelly, Luca Zilberstein
OBJECTIVE: To compare the duration, quality of anaesthesia and analgesia, and quality of recovery of dexmedetomidine and methadone combined with either ketamine or alfaxalone. STUDY DESIGN: Randomized, prospective clinical trial. ANIMALS: A group of 44 healthy client-owned cats presenting for ovariectomy. METHODS: Cats were randomly assigned to one of the two treatment groups: DAM (n=22), which was administered intramuscularly (IM) dexmedetomidine (15 μg kg(-1)), methadone (0...
May 27, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29149918/oxygen-transfer-in-moving-bed-biofilm-reactor-and-integrated-fixed-film-activated-sludge-processes
#5
(no author information available yet)
A demonstrated approach to design the, so-called, medium-bubble air diffusion network for oxygen transfer into the aerobic zone(s) of moving bed biofilm reactor (MBBR) and integrated fixed-film activated sludge (IFAS) processes is described in this paper. Operational full-scale biological water resource recovery systems treating municipal sewerage demonstrate that medium-bubble air diffusion networks designed using the method presented here provide reliable service. Further improvement is possible, however, as knowledge gaps prevent more rational process designs...
November 17, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29149901/development-and-exploration-of-the-content-validity-of-a-patient-reported-outcome-measure-to-evaluate-the-impact-of-migraine-the-migraine-physical-function-impact-diary-mpfid
#6
Asha Hareendran, Sally Mannix, Anne Skalicky, Martha Bayliss, Andrew Blumenfeld, Dawn C Buse, Pooja R Desai, Brian G Ortmeier, Sandhya Sapra
BACKGROUND: Adults with migraine experience substantial reductions in quality of life during and in-between migraine attacks. Clinical and regulatory guidelines encourage the inclusion of patient reported outcomes for the evaluation of benefits of interventions for migraine. METHODS: The conceptual framework and items for a new patient-reported outcome (PRO) instrument, the Migraine Physical Function Impact Diary (MPFID), were developed using scientific methods recommended to ensure content validity of PRO instruments...
November 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29149856/naukan-ethnobotany-in-post-soviet-times-lost-edibles-and-new-medicinals
#7
Kevin A Jernigan, Olga S Belichenko, Valeria B Kolosova, Darlene J Orr
BACKGROUND: This study focuses on health-related plant use among speakers of the critically endangered Naukan language (Inuit-Yupik-Unangan family) in the Russian Far East. The Naukan people were forced, in 1958, under Soviet consolidation, to move from their original settlement on Cape Dezhnev, leading to significant changes in spiritual worldview, subsistence, social structure, and language proficiency in the years that followed. Here, we focus on changes that elders report in their edible, medicinal, and spiritual uses of local plant species since their childhood...
November 17, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29149622/the-chemokine-receptor-type-4-antagonist-amd3100-interrupts-experimental-tooth-movement-in-rats
#8
Kasumi Hatano, Yuji Ishida, Hiroyuki Yamaguchi, Jun Hosomichi, Jun-Ichi Suzuki, Risa Usumi-Fujita, Yasuhiro Shimizu, Naoki Shibutani, Sawa Kaneko, Takashi Ono
OBJECTIVE: The aim of this study was to clarify the role of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis in osteoclast accumulation, and the influence of orthodontic tooth movement (OTM) under mechanical force application to periodontal tissues, by administration of the CXCR4 antagonist AMD3100. DESIGN: The upper right first molar (M1) of rats was moved mesially with a 10-g force titanium-nickel closed coil spring. Rats were treated with phosphate-buffered saline or AMD3100 (5mg/kg), which is a SDF-1 antagonist...
November 11, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29149621/the-risk-factors-related-to-bruxism-in-children-a-systematic-review-and-meta-analysis
#9
REVIEW
Huaqi Guo, Tongxia Wang, Xiaohong Niu, Hui Wang, Weihan Yang, Jie Qiu, Lan Yang
OBJECTIVE: This systematic review was performed to determine the risk factors related to bruxism in children. DESIGN: This systematic review was conducted with reporting in agreement to the PRISMA statement and according to guidelines from the Cochrane Handbook for Systematic Reviews of Interventions. We conducted a systematic search of seven online databases, with the last search updated on 1st October 2016. The seven databases were Pubmed, Embase, Cochrane Library database, Web of Science, CNKI, CBM, and WF...
November 11, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29149609/snapshot-functions-of-endoplasmic-reticulum-membrane-contact-sites
#10
Raquel Salvador-Gallego, Melissa J Hoyer, Gia K Voeltz
The endoplasmic reticulum (ER) consists of the nuclear envelope and a reticulated interconnected network of tubules and sheets. ER sheets are studded with ribosomes and provide the entryway for proteins into the secretory pathway. ER tubules move dynamically on microtubules and form membrane contact sites with other organelles, where membranes are tethered, but not fused. This Snapshot reviews key biological processes that take place at ER contact sites with the Golgi, endosomes, and mitochondria.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149499/being-there-and-reconnecting-midwives-perceptions-of-the-impact-of-mindfulness-training-on-their-practice
#11
Louise Hunter, Sarah Snow, Sian Warriner
OBJECTIVE: To ascertain how midwives perceived attending a mindfulness course impacted on their professional practice, particularly in regard to any stress they experienced at work. DESIGN: A qualitative study using Interpretive Phenomenological Analysis. Semi-structured interviews were conducted with nine midwives. SETTING: A large maternity Trust in the United Kingdom. INTERVENTION: An eight-week Mindfulness course, adapted from Mindfulness-based Cognitive Therapy...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29149239/label-free-in-vivo-imaging-of-corneal-lymphatic-vessels-using-microscopic-optical-coherence-tomography
#12
Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods: Corneal neovascularization was induced by intrastromal placement of 11...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29149215/longitudinal-survey-of-two-serotine-bat-eptesicus-serotinus-maternity-colonies-exposed-to-eblv-1-european-bat-lyssavirus-type-1-assessment-of-survival-and-serological-status-variations-using-capture-recapture-models
#13
Emmanuelle Robardet, Christophe Borel, Marie Moinet, Dorothée Jouan, Marine Wasniewski, Jacques Barrat, Franck Boué, Elodie Montchâtre-Leroy, Alexandre Servat, Olivier Gimenez, Florence Cliquet, Evelyne Picard-Meyer
This study describes two longitudinal serological surveys of European Bat Lyssavirus type 1 (EBLV-1) antibodies in serotine bat (Eptesicus serotinus) maternity colonies located in the North-East of France. This species is currently considered as the main EBLV-1 reservoir. Multievent capture-recapture models were used to determine the factors influencing bat rabies transmission as this method accounts for imperfect detection and uncertainty in disease states. Considering the period of study, analyses revealed that survival and recapture probabilities were not affected by the serological status of individuals, confirming the capacity of bats to be exposed to lyssaviruses without dying...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29148823/space-dust-collisions-as-a-planetary-escape-mechanism
#14
Arjun Berera
It is observed that hypervelocity space dust, which is continuously bombarding Earth, creates immense momentum flows in the atmosphere. Some of this fast space dust inevitably will interact with the atmospheric system, transferring energy and moving particles around, with various possible consequences. This paper examines, with supporting estimates, the possibility that by way of collisions the Earth-grazing component of space dust can facilitate planetary escape of atmospheric particles, whether they are atoms and molecules that form the atmosphere or larger-sized particles...
November 17, 2017: Astrobiology
https://www.readbyqxmd.com/read/29148812/behavior-of-a-liquid-bridge-between-nonparallel-hydrophobic-surfaces
#15
Mohammadmehdi Ataei, Huanchen Chen, Alidad Amirfazli
When a liquid bridge is formed between two nonparallel identical surfaces, it can move along the surfaces. Literature indicates that the direction of bridge movement is governed by the wettability of surfaces. When the surfaces are hydrophilic, the motion of the bridge is always towards the cusp (intersection of the plane of the two bounding surfaces). While, the movement is hitherto thought to be always pointing away from the cusp, when the surfaces are hydrophobic. In this study, through experiments, numerical simulations, and analytical reasoning, we demonstrate that for hydrophobic surfaces, wettability is not the only factor determining the direction of the motion...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148715/ultrafast-long-range-charge-separation-in-nonfullerene-organic-solar-cells
#16
Yasunari Tamai, Yeli Fan, Vincent O Kim, Kostiantyn Ziabrev, Akshay Rao, Stephen Barlow, Seth R Marder, Richard H Friend, S Matthew Menke
Rapid, long-range charge separation in polymer-fullerene organic solar cells (OSCs) enables electrons and holes to move beyond their Coulomb capture radius and overcome geminate recombination. Understanding the nature of charge generation and recombination mechanisms in efficient, nonfullerene-acceptor-based OSCs are critical to further improve device performance. Here we report charge dynamics in an OSC using a perylene diimide (PDI) dimer acceptor. We use transient absorption spectroscopy to track the time evolution of electroabsorption caused by the dipolar electric field generated between electron-hole pairs as they separate after ionization at the donor-acceptor interface...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29148611/biomechanical-investigation-of-the-modified-tardieu-scale-in-assessing-knee-extensor-spasticity-poststroke
#17
Samaneh Gholami, Noureddin Nakhostin Ansari, Soofia Naghdi, Azadeh Tabatabaei, Davood Jannat, Maryam Senobari, Mahdi Dadgoo
OBJECTIVE: The modified Tardieu Scale (MTS) is a clinical tool for the measurement of muscle spasticity. The present study aimed to investigate the relationship between the MTS and the slope of the work-velocity curve as a biomechanical measure in assessing knee extensor muscle spasticity in patients with stroke. METHODS: Thirty patients with stroke (22 female, 8 male; mean age 55.4 ± 12.0 years) participated in this study. The knee extensor spasticity was assessed with the MTS...
November 17, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29148538/molecular-testing-for-braf-mutations-to-inform-melanoma-treatment-decisions-a-move-toward-precision-medicine
#18
Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Gregory T MacLennan, Rodolfo Montironi
Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a mutation in the BRAF gene, with V600E being the most common mutation. Targeted therapy with BRAF and MEK inhibitors is associated with significant long-term treatment benefit in patients with BRAF V600-mutated melanoma. Therefore, molecular testing for BRAF mutations is a priority in determining the course of therapy. A literature search was performed using MEDLINE/PubMed and scientific congress databases using the terms 'BRAF,' 'mutation,' and 'cancer/tumor...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29148322/the-health-care-job-engine-where-do-they-come-from-and-what-do-they-say-about-our-future
#19
Bianca K Frogner
Health care has been cited as a job engine for the U.S. economy. This study used the Current Population Survey to examine the sector and occupation shifts that underlie this growth trend. Health care has had a cyclical relationship with retail trade, leisure and hospitality, education, and professional services. The entering workforce has been increasingly taking on low-skilled occupations. The exiting workforce has not been necessarily retiring or going back to school, but appeared to be leaving without a job, with potentially more child care duties, and with high rates of disability and poverty levels...
January 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29148287/does-the-brief-observation-of-social-communication-change-help-moving-forward-in-measuring-change-in-early-autism-intervention-studies
#20
Mirjam Kj Pijl, Nanda Nj Rommelse, Monica Hendriks, Manon Wp De Korte, Jan K Buitelaar, Iris J Oosterling
The field of early autism research is in dire need of outcome measures that adequately reflect subtle changes in core autistic behaviors. This article compares the ability of a newly developed measure, the Brief Observation of Social Communication Change (BOSCC), and the Autism Diagnostic Observation Schedule (ADOS) to detect changes in core symptoms of autism in 44 toddlers. The results provide encouraging evidence for the Brief Observation of Social Communication Change as a candidate outcome measure, as reflected in sufficient inter- and intra-rater reliability, independency from other child characteristics, and sensitivity to capture change...
December 1, 2016: Autism: the International Journal of Research and Practice
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