keyword
MENU ▼
Read by QxMD icon Read
search

Move

keyword
https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#1
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28651096/predicting-actions-from-subtle-preparatory-movements
#2
Maryam Vaziri-Pashkam, Sarah Cormiea, Ken Nakayama
To study how people anticipate others' actions, we designed a competitive reaching task. Subjects faced each other separated by a Plexiglas screen and their finger movements in 3D space were recorded with sensors. The first subject (Attacker) was instructed to touch one of two horizontally arranged targets on the screen. The other subject (Blocker) touched the same target as quickly as possible. Average finger reaction times (fRTs) were fast, much faster than reactions to a dot moving on the screen in the same manner as the Attacker's finger...
June 23, 2017: Cognition
https://www.readbyqxmd.com/read/28651095/the-influence-of-performance-on-action-effect-integration-in-sense-of-agency
#3
Wen Wen, Atsushi Yamashita, Hajime Asama
Sense of agency refers to the subjective feeling of being able to control an outcome through one's own actions or will. Prior studies have shown that both sensory processing (e.g., comparisons between sensory feedbacks and predictions basing on one's motor intentions) and high-level cognitive/constructive processes (e.g., inferences based on one's performance or the consequences of one's actions) contribute to judgments of sense of agency. However, it remains unclear how these two types of processes interact, which is important for clarifying the mechanisms underlying sense of agency...
June 23, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28650979/expression-of-cerebral-serotonin-related-to-anxiety-like-behaviors-in-c57bl-6-offspring-induced-by-repeated-subcutaneous-prenatal-exposure-to-low-dose-lipopolysaccharide
#4
Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Liu
Prenatal exposure to lipopolysaccharide (LPS), which likely occurs due to infection or contact with environmental allergens during pregnancy, is a proposed risk factor that induces anxiety- and autism spectrum disorder-like behaviors in offspring. However, the molecular and behavioral changes in offspring after maternal immune activation have not been completely identified. We hypothesized that a subcutaneous injection of LPS in a pregnant mouse would induce changes in cerebral serotonin (5-HT) in parallel to the appearance of anxiety-like behaviors in the dam's offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28650955/netnorm-capturing-cancer-relevant-information-in-somatic-exome-mutation-data-with-gene-networks-for-cancer-stratification-and-prognosis
#5
Marine Le Morvan, Andrei Zinovyev, Jean-Philippe Vert
Genome-wide somatic mutation profiles of tumours can now be assessed efficiently and promise to move precision medicine forward. Statistical analysis of mutation profiles is however challenging due to the low frequency of most mutations, the varying mutation rates across tumours, and the presence of a majority of passenger events that hide the contribution of driver events. Here we propose a method, NetNorM, to represent whole-exome somatic mutation data in a form that enhances cancer-relevant information using a gene network as background knowledge...
June 26, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28650951/development-and-progression-of-a-lamellar-macular-hole-with-lamellar-hole-associated-epiretinal-proliferation
#6
Denise Compera, Matteo G Cereda, Ricarda G Schumann, Ferdinando Bottoni
PURPOSE: To describe evolution and progression of a lamellar macular hole (LMH) with "lamellar hole-associated epiretinal proliferation (LHEP)" using spectral-domain optical coherence tomography and fundus autofluorescence. METHODS: Observational case report. RESULTS: We report on a 63-year-old male patient demonstrating a complete history of LMH development with LHEP occurring during a follow-up period of 8 years. Presenting with a normal foveal contour and attached posterior vitreous at first visit, an LMH developed shortly after incomplete posterior vitreous detachment with vitreopapillary adhesion...
June 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28650873/perceptions-of-ambulatory-workflow-changes-in-an-academic-primary-care-setting
#7
Michael A Hanak, Colleen McDevitt, Daniel P Dunham
As health care moves to a value-based system, the need for team-based models of care becomes increasingly important to adequately address the growing number of clinical quality metrics required of health care providers. Finding ways to better engage certified medical assistants (CMAs) in the process allows providers to focus on more complex tasks while improving the efficiency of each office visit. Although the roles and responsibilities for CMAs across the specialties can vary widely, standardizing the work can be a helpful step in scaling best practices across an institution...
June 23, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28650827/neural-decomposition-of-time-series-data-for-effective-generalization
#8
Luke B Godfrey, Michael S Gashler
We present a neural network technique for the analysis and extrapolation of time-series data called neural decomposition (ND). Units with a sinusoidal activation function are used to perform a Fourier-like decomposition of training samples into a sum of sinusoids, augmented by units with nonperiodic activation functions to capture linear trends and other nonperiodic components. We show how careful weight initialization can be combined with regularization to form a simple model that generalizes well. Our method generalizes effectively on the Mackey-Glass series, a data set of unemployment rates as reported by the U...
June 22, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28650816/collision-avoidance-behavior-between-walkers-global-and-local-motion-cues
#9
Laurentius Lynch, Richard Kulpa, Antonius Laurentius Meerhoff, Julien Pettre, Armel Cretual, Anne-Helene Olivier
Daily activities require agents to interact with each other, such as during collision avoidance. The nature of visual information that is used for a collision free interaction requires further understanding. We aim to manipulate the nature of visual information in two forms, global and local information appearances. Sixteen healthy participants navigated towards a target in an immersive computer-assisted virtual environment (CAVE) using a joystick. A moving passive obstacle crossed the participant?s trajectory perpendicularly at various pre-defined risks of collision distances...
June 22, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28650178/the-role-of-morbidity-for-proxy-reported-well-being-in-the-last-year-of-life
#10
Katharina Gerlach, Nilam Ram, Frank J Infurna, Nina Vogel, Gert G Wagner, Denis Gerstorf
Late-life well-being often shows steep deteriorations, but the contributing factors are not well understood, in part because data about people's final year of life are scarce. Here, we draw from and test theoretical perspectives that health-related vulnerabilities undermine the experience and skills older adults typically use to maintain well-being (Charles, 2010). To do so, we examined how various morbidity factors shape final-year well-being trajectories. We applied change score models to retrospective proxy-reports from the Socio-Economic Panel (N = 1,776; age at death = 19-101 years; 47% women) and covary for characteristics of the deceased and the bereaved proxy...
June 26, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28650174/dissolution-processes-at-step-edges-of-calcite-in-water-investigated-by-high-speed-frequency-modulation-atomic-force-microscopy-and-simulation
#11
Kazuki Miyata, John Tracey, Keisuke Miyazawa, Ville Anton Haapasilta, Peter Spijker, Yuta Kawagoe, Adam S Foster, Katsuo Tsukamoto, Takeshi Fukuma
The microscopic understanding of the crystal growth and dissolution processes have been greatly advanced by the direct imaging of nanoscale step flows by atomic force microscopy (AFM), optical interferometry and x-ray microscopy. However, one of the most fundamental events that govern their kinetics, namely, atomistic events at the step edges have not been well understood. In this study, we have developed high-speed frequency modulation AFM (FM-AFM) and enabled true atomic-resolution imaging in liquid at ~1 s/frame, which is ~50 times faster than the conventional FM-AFM...
June 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28650031/diffusiophoretic-manipulation-of-particles-in-a-drop-deposited-on-a-hydrogel
#12
François Boulogne, Sangwoo Shin, Julien Dervaux, Laurent Limat, Howard A Stone
We report an experimental study on the manipulation of colloidal particles in a drop sitting on a hydrogel. The manipulation is achieved by diffusiophoresis, which describes a directed motion of particles induced by solute gradients. By letting the solute concentrations for the drop and the hydrogel be different, we control the motion of particles in a stable suspension, which is otherwise difficult to achieve. We show that diffusiophoresis can cause the particles to move either toward or away from the liquid-air interface depending on the direction of the solute gradient and the surface charge of the particles...
June 26, 2017: Soft Matter
https://www.readbyqxmd.com/read/28649908/linear-perspective-and-framing-in-the-vista-paradox
#13
Marco Costa, Leonardo Bonetti
The vista paradox is the illusion in which an object seen through an aperture appears to shrink in apparent size as the observer approaches the aperture. In four studies, we tested the effect of framing and fixating on the target object. The first two studies assessed the vista paradox in a large scale naturalistic setting in which a 162.26 -m long corridor was aligned to a 97.2 -m high tower (1,407 m away). In the first study, the results showed, for each 16 m section, a mean 9.95% tower enlargement in the moving backward condition, and a mean 11...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28649849/toward-establishing-a-standard-symptom-set-for-assessing-sluggish-cognitive-tempo-in-children-evidence-from-teacher-ratings-in-a-community-sample
#14
Stephen P Becker, G Leonard Burns, Aidan P Schmitt, Jeffery N Epstein, Leanne Tamm
Despite increasing interest in sluggish cognitive tempo (SCT) in children, the field is stymied by the lack of a standard symptom set that can be used across studies. Without a standard symptom set, it is difficult to determine if differences across studies are due to methodological or sample differences, or simply the way SCT was measured. To move the field toward a standard symptom set, this study evaluates a teacher-report rating scale of SCT revised based on recent meta-analytic findings that identified optimal items for distinguishing SCT from attention-deficit/hyperactivity disorder inattention (ADHD-IN)...
June 1, 2017: Assessment
https://www.readbyqxmd.com/read/28649741/the-emerging-science-of-linked-plant-fungal-invasions
#15
REVIEW
Ian A Dickie, Jennifer L Bufford, Richard C Cobb, Marie-Laure Desprez-Loustau, Gwen Grelet, Philip E Hulme, John Klironomos, Andreas Makiola, Martin A Nuñez, Anne Pringle, Peter H Thrall, Samuel G Tourtellot, Lauren Waller, Nari M Williams
I. II. III. IV. V. VI. VII. VIII. References SUMMARY: Invasions of alien plants are typically studied as invasions of individual species, yet interactions between plants and symbiotic fungi (mutualists and potential pathogens) affect plant survival, physiological traits, and reproduction and hence invasion success. Studies show that plant-fungal associations are frequently key drivers of plant invasion success and impact, but clear conceptual frameworks and integration across studies are needed to move beyond a series of case studies towards a more predictive understanding...
June 26, 2017: New Phytologist
https://www.readbyqxmd.com/read/28649647/moonshots-and-metastatic-disease-the-need-for-a-multi-faceted-approach-when-studying-atypical-responses
#16
REVIEW
Kristine De La Torre, Elly Cohen, Anne Loeser, Marc Hurlbert
Clinical research generally focuses on results involving a statistical mean with little attention in trial design to patients who respond considerably better or worse than average. Exploring the reasons underlying an "atypical response" will increase understanding of the mechanisms involved in cancer progression and treatment resistance, accelerate biomarker identification, and improve precision medicine by allowing clinicians to prospectively select optimal treatments. Based on our review, we suggest two ways to move this field forward...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28649294/randomised-controlled-trial-of-a-baked-egg-intervention-in-young-children-allergic-to-raw-egg-but-not-baked-egg
#17
Merryn Netting, Michael Gold, Patrick Quinn, Adaweyah El-Merhibi, Irmeli Penttila, Maria Makrides
BACKGROUND: Consumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children. METHODS: In a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (n = 21 intervention group) or similar egg free baked goods (n = 22 control group) while maintaining an otherwise egg free diet...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28649149/quantitative-imaging-of-cell-membrane-associated-effective-mass-density-using-photonic-crystal-enhanced-microscopy-pcem
#18
Yue Zhuo, Ji Sun Choi, Thibault Marin, Hojeong Yu, Brendan A Harley, Brian T Cunningham
Adhesion is a critical cellular process that contributes to migration, apoptosis, differentiation, and division. It is followed by the redistribution of cellular materials at the cell membrane or at the cell-surface interface for cells interacting with surfaces, such as basement membranes. Dynamic and quantitative tracking of changes in cell adhesion mass redistribution is challenging because cells are rapidly moving, inhomogeneous, and nonequilibrium objects, whose physical and mechanical properties are difficult to measure or predict...
November 2016: Prog Quantum Electron
https://www.readbyqxmd.com/read/28648891/implications-of-the-vienna-integrated-model-of-art-perception-for-art-based-interventions-in-clinical-populations-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap
#19
https://www.readbyqxmd.com/read/28648847/study-on-the-change-and-acculturation-of-dietary-pattern-of-southeast-asian-workers-living-in-south-korea
#20
Eun Jung Lee, Kyung-Ran Lee, Seung-Joo Lee
This study analyzed the dietary pattern of Southeast Asian workers (Vietnamese, Thais, Cambodians and Myanmar) living in South Korea in order to recognize the dietary changes after they moved to South Korea. Questionnaires were completed by 251 Southeast Asian workers living in South Korea. Using a self-administered questionnaire, we assessed the diets before and after living in the hometown and in South Korea. Significant changes observed in the Southeast Asian workers were decreased in consumption frequency of fresh fruits, cooked vegetables, rice noodles, green tea and glutinous rice, and increase in consumption of Kimchi, seaweed, milk, coffee and pizza...
June 22, 2017: Appetite
keyword
keyword
19071
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"