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https://www.readbyqxmd.com/read/29129698/evaluation-of-different-parameters-of-humoral-and-cellular-immune-responses-in-hiv-serodiscordant-heterosexual-couples-humoral-response-potentially-implicated-in-modulating-transmission-rates
#1
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental. In this context, cohorts of HIV serodiscordant heterosexual couples (SDC) represent a unique tool. The present study was aimed to evaluate specific parameters of innate, cellular and humoral immune responses in SDC. Specifically, plasma levels of cytokines and chemokines, HIV-specific T-cell responses, gp120-specific IgG and IgA antibodies, and HIV-specific antibody-dependent cellular cytotoxicity (ADCC) activity were assessed in nine HIV-exposed seronegative individuals (ESN) and their corresponding HIV seropositive partners (HIV(+)-P), in eighteen chronically infected HIV subjects (C), nine chronically infected subjects known to be HIV transmitters (CT) and ten healthy HIV(-) donors (HD)...
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29077673/condomless-sex-among-virally-suppressed-women-with-hiv-with-regular-hiv-serodiscordant-sexual-partners-in-the-era-of-treatment-as-prevention
#2
Sophie Patterson, Allison Carter, Valerie Nicholson, Kath Webster, Erin Ding, Mary Kestler, Gina Ogilvie, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
BACKGROUND: Sexual HIV transmission does not occur with sustained undetectable viral load (VL) on antiretroviral therapy (ART). Awareness of ART prevention benefits and its influence on condom use among women with HIV (WWH) remain unexplored. We estimated prevalence and correlates of condomless sex with regular HIV-serodiscordant partners among WWH with undetectable VL on ART. METHODS: We used baseline questionnaire data from the community-based longitudinal Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29076883/intimate-partner-violence-and-self-reported-pre-exposure-prophylaxis-prep-interruptions-among-hiv-negative-partners-in-hiv-serodiscordant-couples-in-kenya-and-uganda
#3
Alejandra Cabral, Jared Baeten, Kenneth Ngure, Jennifer Velloza, Josephine Odoyo, Jessica Haberer, Connie Celum, Timothy Muwonge, Stephen Asiimwe, Renee Heffron
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention and PrEP delivery studies are investigating ways to deliver PrEP with high adherence. However, in many settings with high HIV burden, intimate partner violence (IPV) is reported often and could be a barrier to effective PrEP use. We examined the association between IPV and interruptions in PrEP use. METHODS: We analyzed data from 1,013 serodiscordant heterosexual couples enrolled in a large PrEP demonstration project in Kenya and Uganda, the Partners Demonstration Project...
October 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29076033/patterns-of-online-and-offline-connectedness-among-gay-bisexual-and-other-men-who-have-sex-with-men
#4
Kiffer G Card, Heather L Armstrong, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Eric A Roth, Robert S Hogg
This study examined patterns of connectedness among 774 sexually-active gay, bisexual, and other men who have sex with men (GBM), aged ≥ 16 years, recruited using respondent-driven sampling in Metro Vancouver. Latent class analysis examined patterns of connectedness including: attendance at gay venues/events (i.e., bars/clubs, community groups, pride parades), social time spent with GBM, use of online social and sex seeking apps/websites, and consumption of gay media. Multinomial regression identified correlates of class membership...
October 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29073829/hiv-testing-among-male-partners-of-pregnant-women-in-nigeria-a-missing-link-in-the-elimination-of-mother-to-child-transmission-of-hiv
#5
Babayemi O Olakunde, Daniel A Adeyinka, Tolulope Oladele, Chamberline E Ozigbu
In this study, we assessed male partner testing and the serodiscordance rate among pregnant women and their partners in the prevention of mother-to-child transmission (PMTCT) programme in Nigeria. We conducted a retrospective analysis of the consolidated national health sector PMTCT data over a five-year period (2012-2016). Over the period, a total of 11,833,062 pregnant women were tested for HIV with a positivity rate of 2.2%. About 266,188 (2.2%) of sexual partners of pregnant women who presented at PMTCT clinics had an HIV test within the period...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29040666/maternal-tenofovir-disoproxil-fumarate-use-during-pregnancy-is-not-associated-with-adverse-perinatal-outcomes-among-hiv-infected-east-african-women-a-prospective-study
#6
Jillian Pintye, Jared M Baeten, Connie Celum, Nelly Mugo, Kenneth Ngure, Edwin Were, Elizabeth Bukusi, Grace John-Stewart, Renee A Heffron
Background: Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and pre-exposure prophylaxis regimens. We evaluated the relationship between adverse perinatal outcomes and prenatal TDF use. Methods: Longitudinal data were analyzed from HIV-infected women who became pregnant during two HIV prevention studies conducted among HIV-serodiscordant couples in Kenya and Uganda. Pregnancies were included if singleton, not terminated by an induced abortion and had documentation of 3-drug ART use...
October 10, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29026872/top-questions-in-id-pre-exposure-prophylaxis-for-hiv
#7
Douglas S Krakower, Stephanie E Cohen, Kenneth H Mayer
HIV pre-exposure prophylaxis (PrEP) is highly efficacious at preventing HIV acquisition. This review discusses ways to identify candidates for PrEP, recommended PrEP regimens, baseline and follow-up evaluations, applications of PrEP for HIV-serodiscordant couples, resources to address financial barriers, investigational strategies for PrEP, and educational resources for clinicians and patients.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29016523/prep-use-during-periods-of-hiv-risk-among-east-african-women-in-serodiscordant-relationships
#8
Maria Pyra, Jessica E Haberer, Renee Heffron, Lara Kidoguchi, Elizabeth R Brown, Elizabeth A Bukusi, Stephen Asiimwe, Connie Celum, Elly Katabira, Nelly R Mugo, Jared M Baeten
BACKGROUND: PrEP is efficacious for African women at risk for HIV, but data on adherence outside of clinical trials are sparse. We describe the persistence and execution of PrEP use among women participating in a large open-label PrEP demonstration project, particularly during periods of HIV risk. SETTING: & Methods: 310 HIV-uninfected women in HIV serodiscordant couples in Kenya and Uganda were offered and accepted PrEP. Electronic monitoring caps were used to measure daily PrEP adherence...
September 29, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28991882/belief-in-treatment-as-prevention-and-its-relationship-to-hiv-status-and-behavioral-risk
#9
Kiffer G Card, Heather L Armstrong, Nathan J Lachowsky, Zishan Cui, Paul Sereda, M Allison Carter, Julio S G Montaner, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: We evaluated attitudes towards Treatment as Prevention (TasP) among gay, bisexual, and other men who have sex with men (GBM) in Vancouver, Canada. METHODS: Sexually-active GBM, aged >16, were recruited between 2012-2015 using respondentdriven sampling. At each six-month follow-up, participants completed a computer-administered questionnaire and nursing visit. Repeated measures latent class analysis (RMLCA), grouped by self-reported serostatus, identified patterns of TasP-endorsement by considering TasP-related awareness, attitudes, and behavior...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28975477/meta-analysis-of-alcohol-and-serodiscordant-condomless-sex-among-people-living-with-hiv
#10
Sarahmona M Przybyla, Gabriela Krawiec, Stephanie A Godleski, Cory A Crane
While observational studies have found that alcohol consumption is associated with serodiscordant condomless sex among people living with HIV (PLHIV), no meta-analysis has yet examined this trend. We conducted a meta-analysis to synthesize empirical evidence on the association between alcohol and condomless sex with partners at risk of HIV acquisition. To meet inclusion criteria, studies: (1) specifically targeted PLHIV or provided stratified data for HIV-infected participants; (2) provided a quantitative measure of alcohol use; (3) provided a quantitative measure of condomless sex with serodiscordant partners; and (4) reported the results of statistical tests examining the relationship between alcohol use and serodiscordant condomless sex...
October 3, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28966620/the-significance-of-discordant-serology-in-chagas-disease-enhanced-t-cell-immunity-to-trypanosoma-cruzi-in-serodiscordant-subjects
#11
Melisa D Castro Eiro, María G Alvarez, Gretchen Cooley, Rodolfo J Viotti, Graciela L Bertocchi, Bruno Lococo, María C Albareda, Ana M De Rissio, María A Natale, Cecilia Parodi, Rick L Tarleton, Susana A Laucella
BACKGROUND: Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from infected individuals among SD subjects. METHODS: Peripheral blood mononuclear cells from SD and seropositive (SP) subjects, who were born in areas endemic for T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28961676/brief-report-context-matters-prep-adherence-is-associated-with-sexual-behavior-among-hiv-serodiscordant-couples-in-east-africa
#12
Jessica E Haberer, Kenneth Ngure, Timothy Muwonge, Nelly Mugo, Elly Katabira, Renee Heffron, Nicholas Musinguzi, David R Bangsberg, Connie Celum, Jared M Baeten
BACKGROUND: Short message service (SMS) surveys are a promising tool for understanding whether preexposure prophylaxis (PrEP) adherence aligns with risk for HIV acquisition-a concept known as prevention-effective adherence. METHODS: The Partners Demonstration Project was an open-label study of integrated PrEP and antiretroviral therapy (ART) delivery among high-risk HIV serodiscordant couples in East Africa. HIV-uninfected partners were offered PrEP until their HIV-infected partner had taken ART for ≥6 months...
December 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28956345/erratum-to-risky-sex-and-hiv-acquisition-among-hiv-serodiscordant-couples-in-zambia-2002-2012-what-does-alcohol-have-to-do-with-it
#13
Dvora Joseph Davey, William Kilembe, Kristin M Wall, Naw Htee Khu, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakht, W Scott Comulada, Susan Allen, Pamina M Gorbach
The article Risky Sex and HIV Acquisition Among HIV Serodiscordant Couples in Zambia, 2002-2012: What Does Alcohol Have To Do With It?, written by Dvora Joseph Davey, William Kilembe, Kristin M. Wall, Naw Htee Khu, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakht, W. Scott Comulada, Susan Allen, Pamina M. Gorbach, was originally published Online First without open access. After publication in volume 21, issue 7, pages 1892-1903, the author decided to opt for Open Choice and to make the article an open access publication...
September 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28903628/what-motivates-serodiscordant-couples-to-prevent-hiv-transmission-within-their-relationships-findings-from-a-prep-implementation-study-in-kenya
#14
Rena C Patel, Anna M Leddy, Josephine Odoyo, Keerthana Anand, Gaelen Stanford-Moore, Imeldah Wakhungu, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown
With the planned scale-up of pre-exposure prophylaxis (PrEP) for HIV prevention among serodiscordant couples in resource-limited settings, gaining an understanding of what motivates serodiscordant couples to prevent HIV is critical. We conducted 44 semi-structured, in-depth individual or couple interviews with 63 participants (33 HIV-infected and 30 HIV-uninfected participants) enrolled in a prospective implementation study of oral antiretroviral-based prevention in Kisumu, Kenya. Transcripts were iteratively analysed using inductive content analysis...
September 14, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28899162/high-levels-of-viral-suppression-among-east-african-hiv-infected-women-and-men-in-serodiscordant-partnerships-initiating-antiretroviral-therapy-with-high-cd4-counts-and-during-pregnancy
#15
Andrew Mujugira, Jared Baeten, Lara Kidoguchi, Jessica Haberer, Connie Celum, Deborah Donnell, Kenneth Ngure, Elizabeth Bukusi, Nelly Mugo, Stephen Asiimwe, Josephine Odoyo, Edna Tindimwebwa, Nulu Bulya, Elly Katabira, Renee Heffron
BACKGROUND: People who are asymptomatic and feel healthy, including pregnant women, may be less motivated to initiate ART or achieve high adherence. We assessed whether ART initiation, and viral suppression 6, 12 and 24-months after ART initiation, were lower in HIV-infected members of serodiscordant couples who initiated during pregnancy or with higher CD4 counts. METHODS: We used data from the Partners Demonstration Project, an open-label study of the delivery of integrated PrEP and ART (at any CD4 count) for HIV prevention among high-risk HIV serodiscordant couples in Kenya and Uganda...
September 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28894986/fertility-intentions-pregnancy-and-use-of-prep-and-art-for-safer-conception-among-east-african-hiv-serodiscordant-couples
#16
Renee Heffron, Kerry Thomson, Connie Celum, Jessica Haberer, Kenneth Ngure, Nelly Mugo, Elizabeth Bukusi, Elly Katabira, Josephine Odoyo, Nulu Bulya, Stephen Asiimwe, Edna Tindimwebwa, Jared M Baeten
African HIV serodiscordant couples often desire pregnancy, despite sexual HIV transmission risk during pregnancy attempts. Pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) reduce HIV risk and can be leveraged for safer conception but how well these strategies are used for safer conception is not known. We conducted an open-label demonstration project of the integrated delivery of PrEP and ART among 1013 HIV serodiscordant couples from Kenya and Uganda followed quarterly for 2 years. We evaluated fertility intentions, pregnancy incidence, the use of PrEP and ART during peri-conception, and peri-conception HIV incidence...
September 11, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28880892/beyond-hiv-serodiscordance-partnership-communication-dynamics-that-affect-engagement-in-safer-conception-care
#17
Lynn T Matthews, Bridget F Burns, Francis Bajunirwe, Jerome Kabakyenga, Mwebesa Bwana, Courtney Ng, Jasmine Kastner, Annet Kembabazi, Naomi Sanyu, Adrine Kusasira, Jessica E Haberer, David R Bangsberg, Angela Kaida
INTRODUCTION: We explored acceptability and feasibility of safer conception methods among HIV-affected couples in Uganda. METHODS: We recruited HIV-positive men and women on antiretroviral therapy (ART) ('index') from the Uganda Antiretroviral Rural Treatment Outcomes cohort who reported an HIV-negative or unknown-serostatus partner ('partner'), HIV-serostatus disclosure to partner, and personal or partner desire for a child within two years. We conducted in-depth interviews with 40 individuals from 20 couples, using a narrative approach with tailored images to assess acceptability of five safer conception strategies: ART for the infected partner, pre-exposure prophylaxis (PrEP) for the uninfected partner, condomless sex timed to peak fertility, manual insemination, and male circumcision...
2017: PloS One
https://www.readbyqxmd.com/read/28872418/pregnancy-planning-preferences-among-people-and-couples-affected-by-human-immunodeficiency-virus-piloting-a-discrete-choice-experiment
#18
Mona Loutfy, V Logan Kennedy, Morvarid Sanandaji, Fatimatou Barry, Fanta Ongoiba, Marvelous Muchenje, Wangari Tharao, Dean A Regier
Decision-making related to pregnancy planning is complex and human immunodeficiency virus (HIV) may further complicate the process. With increasing rates of pregnancy among individuals affected by HIV, the need to understand decision-making is imperative. The primary objectives of this pilot study were to confirm the feasibility of using discrete choice experimentation (DCE) to elicit an understanding of this process and to determine the acceptability of the choice factors that were included in two novel DCEs, while gathering a preliminary understanding of preference...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28843576/effect-of-hsv-2-infection-on-subsequent-hiv-acquisition-an-updated-systematic-review-and-meta-analysis
#19
Katharine J Looker, Jocelyn A R Elmes, Sami L Gottlieb, Joshua T Schiffer, Peter Vickerman, Katherine M E Turner, Marie-Claude Boily
BACKGROUND: HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial global disease burden and are epidemiologically correlated. Two previous systematic reviews of the association between HSV-2 and HIV found evidence that HSV-2 infection increases the risk of HIV acquisition, but these reviews are now more than a decade old. METHODS: For this systematic review and meta-analysis, we searched PubMed, MEDLINE, and Embase (from Jan 1, 2003, to May 25, 2017) to identify studies investigating the risk of HIV acquisition after exposure to HSV-2 infection, either at baseline (prevalent HSV-2 infection) or during follow-up (incident HSV-2 infection)...
August 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28819988/behavior-change-following-hiv-diagnosis-findings-from-a-cohort-of-los-angeles-msm
#20
Pamina M Gorbach, Marjan Javanbakht, Robert K Bolan
The effect of an HIV diagnosis on subsequent behavior of men who have sex with men (MSM) remains unclear. From 2009 to 2012 the NIDA funded Metromates Study enrolled and followed for one year MSM seeking testing for HIV in Los Angeles, assessing those with new HIV diagnoses for acute/recent HIV infection. Behavioral data were collected via Computer-Assisted Self-Interview from 321 men of whom 125 were classified as recently HIV infected, 91 as not recently HIV infected, and 105 as HIV-negative. Differences over time between those with recent HIV infection, not recent HIV infection, and no HIV were evaluated using bivariate and multivariable analyses for repeat measures to assess associations between HIV group, behaviors and condomless receptive (CRAI), intersertive (CIAI), or any condomless anal intercourse (CAI)...
August 18, 2017: AIDS Care
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