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https://www.readbyqxmd.com/read/28291050/medication-sharing-is-rare-among-african-hiv-1-serodiscordant-couples-enrolled-in-an-efficacy-trial-of-oral-pre-exposure-prophylaxis-prep-for-hiv-1-prevention
#1
Kerry A Thomson, Jessica E Haberer, Mark Marzinke, Andrew Mujugira, Craig Hendrix, Connie Celum, Patrick Ndase, Alan Ronald, David R Bangsberg, Jared M Baeten
Sharing of pre-exposure prophylaxis (PrEP) medications is a concern for PrEP implementation. For HIV-1 serodiscordant couples, sharing may undermine HIV-1 prevention benefits and also cause antiretroviral resistance if taken by HIV-1 infected partners. Within a PrEP efficacy trial among HIV-1 serodiscordant couples, we assessed the occurrence of PrEP sharing by self-report and plasma tenofovir concentrations in HIV-1 infected partners. PrEP sharing was self-reported at <0.01% of visits and 0-1.6% of randomly selected and 0% of purposively selected specimens from HIV-1 infected participants had detectable tenofovir concentrations (median: 66...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28253283/a-flexible-method-to-model-hiv-serodiscordance-among-couples-in-mozambique
#2
Adelino J C Juga, Niel Hens, Nafissa Osman, Marc Aerts
Whereas the number of people newly infected by HIV is continuing to decline globally, the epidemic continues to expand in many parts of the world. As the HIV/AIDS epidemic has matured in many countries, it is believed that the proportion of new infections occurring within couples has risen. Across countries, including Mozambique, a sizeable proportion of couples with HIV infection are discordant. A serodiscordant couple is a couple in which one partner has tested positive for HIV and the other has not. To describe the HIV serodiscordance among couples, a variety of association measures can be used...
2017: PloS One
https://www.readbyqxmd.com/read/28243934/risky-sex-and-hiv-acquisition-among-hiv-serodiscordant-couples-in-zambia-2002-2012-what-does-alcohol-have-to-do-with-it
#3
Dvora Joseph Davey, William Kilembe, Kristin M Wall, Naw Htee Khu, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakht, W Scott Comulada, Susan Allen, Pamina M Gorbach
In this paper we evaluate the effects of heavy alcohol consumption on sexual behavior, HIV acquisition, and antiretroviral treatment (ART) initiation in a longitudinal open cohort of 1929 serodiscordant couples in Lusaka, Zambia from 2002 to 2012. We evaluated factors associated with baseline heavy alcohol consumption and its association with condomless sex with the study partner, sex outside of the partnership, and ART initiation using multivariable logistic regression. We estimated the effect of alcohol consumption on HIV acquisition using multivariable Cox models...
February 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of%C3%A2-chronic-viral-illness
#4
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C desire to become pregnant. Patients with chronic viral illnesses desire to have children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, hepatitis B, and hepatitis C so that reproductive goals can be addressed and optimized...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28181784/recurrent-herpes-labialis-and-hsv-1-herpes-genitalis-which-is-the-link
#5
Sergio Delmonte, Francesca Sidoti, Simone Ribero, Ivano Dal Conte, Antonio Curtoni, Giulia Ciccarese, Elena Stroppiana, Maria L Stella, Cristina Costa, Rossana Cavallo, Alfredo Rebora, Francesco Drago
BACKGROUND: Recently, Herpes simplex virus (HSV)-1 seroprevalence declined among adolescents, rendering young people lacking HSV-1 antibodies more susceptible to genital HSV-1 acquisition, if sexually exposed. The aim of the present study was to identify the possible risk factors for the development of HSV-1 related herpes genitalis (HG). METHODS: From January 2012 to December 2015, patients with HG attending three Sexually Transmitted Infections Units in Northern Italy were recruited...
February 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28168375/sustained-reduction-in-sexual-behavior-that-may-pose-a-risk-of-hiv-transmission-following-diagnosis-during-early-hiv-infection-among-gay-men-in-vancouver-british-columbia
#6
Mark Gilbert, Darlene Taylor, Warren Michelow, Daniel Grace, Robert Balshaw, Michael Kwag, Elgin Lim, Benedikt Fischer, David Patrick, Gina Ogilvie, Daniel Coombs, Malcolm Steinberg, Michael Rekart
Increased viral load during early HIV infection (EHI) disproportionately contributes to HIV transmission among gay men. We examined changes in sexual behavior that may pose a risk of HIV transmission (condomless anal sex (AS) with a serodiscordant or unknown status partner, CAS-SDU) in a cohort of 25 gay men newly diagnosed during EHI who provided information on 241 sexual partners at six time points following diagnosis. Twenty-two (88%) participants reported ≥1 AS partner (median time to first AS 80 days) and 12 (55%) reported ≥1 partnership involving CAS-SDU (median 116 days)...
February 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28124579/using-a-network-based-approach-and-targeted-maximum-likelihood-estimation-to-evaluate-the-effect-of-adding-pre-exposure-prophylaxis-to-an-ongoing-test-and-treat-trial
#7
Laura Balzer, Patrick Staples, Jukka-Pekka Onnela, Victor DeGruttola
BACKGROUND: Several cluster-randomized trials are underway to investigate the implementation and effectiveness of a universal test-and-treat strategy on the HIV epidemic in sub-Saharan Africa. We consider nesting studies of pre-exposure prophylaxis within these trials. Pre-exposure prophylaxis is a general strategy where high-risk HIV- persons take antiretrovirals daily to reduce their risk of infection from exposure to HIV. We address how to target pre-exposure prophylaxis to high-risk groups and how to maximize power to detect the individual and combined effects of universal test-and-treat and pre-exposure prophylaxis strategies...
January 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28092719/-commentary-on-the-case-request-for-vasectomy-reversion-in-hiv-male-with-serodiscordant-couple
#8
Antonio Pardo
No abstract text is available yet for this article.
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092718/-case-request-for-vasectomy-reversion-in-hiv-male-with-serodiscordant-couple
#9
José Jara Rascon, Esmeralda Alonso Sandoica
No abstract text is available yet for this article.
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28074680/sero-discovering-versus-sero-cognisant-initial-challenges-and-needs-of-hiv-serodiscordant-couples-in-porto-alegre-brazil
#10
Shana D Hughes, Hong-Ha M Truong
This paper focuses on challenges faced by heterosexual couples of mixed HIV status in Porto Alegre, Brazil, and argues for more conceptual nuance in our understanding of 'serodiscordance'. Couples' stories, collected over 11 months of qualitative research, demonstrate how profoundly serodiscordance involves both partners and suggest that the timing of relationship formation relative to HIV diagnosis influenced the particular challenges they confronted. In recognition of this variation, we propose the distinction of 'sero-discovering' from 'sero-cognisant' couples...
January 11, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28056275/-unprotected-sexual-intercourse-and-its-correlates-within-hiv-serodiscordant-couples-in-dehong-prefecture-of-yunnan-province-china-in-2014
#11
Y C Zhang, Y F Cao, Y C Yang, R H Tang, S J Yang, L Li, S T Yao, R H Ye, J B Wang, S Duan, N He
Objective: To study the prevalence and correlates of unprotected sexual intercourse within HIV serodiscordant couples in Dehong prefecture, Yunnan Province, China, in 2014. Methods: This study was based on the follow-up investigation of "the AIDS cohort of seronegative spouses of HIV-infected individuals in Dehong prefecture" in 2014. The 1 520 participants were HIV seronegative spouses from all five counties/cities of Dehong prefecture who voluntarily participated in the cohort. Inclusion criteria included: having a HIV-positive spouse; ≥16 years of age; having had sexual intercourse with spouse in the past year; and being a resident of Dehong prefecture...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28050650/number-of-psychosocial-strengths-predicts-reduced-hiv-sexual-risk-behaviors-above-and-beyond-syndemic-problems-among-gay-and-bisexual-men
#12
Trevor A Hart, Syed W Noor, Barry D Adam, Julia R G Vernon, David J Brennan, Sandra Gardner, Winston Husbands, Ted Myers
Syndemics research shows the additive effect of psychosocial problems on high-risk sexual behavior among gay and bisexual men (GBM). Psychosocial strengths may predict less engagement in high-risk sexual behavior. In a study of 470 ethnically diverse HIV-negative GBM, regression models were computed using number of syndemic psychosocial problems, number of psychosocial strengths, and serodiscordant condomless anal sex (CAS). The number of syndemic psychosocial problems correlated with serodiscordant CAS (RR = 1...
January 3, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28038949/could-misreporting-of-condom-use-explain-the-observed-association-between-injectable-hormonal-contraceptives-and-hiv-acquisition-risk
#13
Jennifer A Smith, Renee Heffron, Ailsa R Butler, Connie Celum, Jared M Baeten, Timothy B Hallett
OBJECTIVE: Some observational studies have suggested an association between the use of hormonal contraceptives (HC) and HIV acquisition. One major concern is that differential misreporting of sexual behavior between HC users and nonusers may generate artificially inflated risk estimates. STUDY DESIGN: We developed an individual-based model that simulates the South African HIV serodiscordant couples analyzed for HC-HIV risk by Heffron et al. (2012). We varied the pattern of misreporting condom use between HC users and nonusers and reproduced the trial data under the assumption that HC use is not associated with HIV risk...
December 28, 2016: Contraception
https://www.readbyqxmd.com/read/28007791/factors-associated-with-seminal-impairment-in-hiv-infected-men-under-antiretroviral-therapy
#14
A Jerónimo, M B Baza, I Río, M Vera, V Hernando, J Castilla, C Rodriguez, J Del Romero
STUDY QUESTION: How do semen parameters of HIV-infected men under antiretroviral treatment compare with WHO parameters of normal semen, and what factors are associated with any differences? SUMMARY ANSWER: Semen quality in most HIV-infected patients under antiretroviral treatment exceeds WHO limits, but the number falling below them is higher than would be expected in a healthy population. Exposure to efavirenz has a significant association with dysmotility. WHAT IS KNOWN ALREADY: Dysmotility is the most frequently described sperm alteration related to HIV infection, and it has recently been linked to treatment with non-nucleoside reverse transcriptase inhibitors, particularly to efavirenz...
December 21, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27997660/serologic-screening-for-genital-herpes-an-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#15
REVIEW
Cynthia Feltner, Catherine Grodensky, Charles Ebel, Jennifer C Middleton, Russell P Harris, Mahima Ashok, Daniel E Jonas
Importance: Genital herpes simplex virus (HSV) infection is a prevalent sexually transmitted infection. Vertical transmission of HSV can lead to fetal morbidity and mortality. Objective: To assess the evidence on serologic screening and preventive interventions for genital HSV infection in asymptomatic adults and adolescents to support the US Preventive Services Task Force for an updated recommendation statement. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries through March 31, 2016...
December 20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27989576/population-levels-and-geographical-distribution-of-hiv-rna-in-rural-ugandan-and-kenyan-communities-including-serodiscordant-couples-a-cross-sectional-analysis
#16
Vivek Jain, Maya L Petersen, Teri Liegler, Dathan M Byonanebye, Dalsone Kwarisiima, Gabriel Chamie, Norton Sang, Doug Black, Tamara D Clark, Andras Ladai, Albert Plenty, Jane Kabami, Emmanuel Ssemmondo, Elizabeth A Bukusi, Craig R Cohen, Edwin D Charlebois, Moses R Kamya, Diane V Havlir
BACKGROUND: As sub-Saharan Africa transitions to a new era of universal antiretroviral therapy (ART), up-to-date assessments of population-level HIV RNA suppression are needed to inform interventions to optimise ART delivery. We sought to measure population viral load metrics to assess viral suppression and characterise demographic groups and geographical locations with high-level detectable viraemia in east Africa. METHODS: The Sustainable East Africa Research in Community Health (SEARCH) study is a cluster-randomised controlled trial of an HIV test-and-treat strategy in 32 rural communities in Uganda and Kenya, selected on the basis of rural setting, having an approximate population of 10 000 people, and being within the catchment area of a President's Emergency Plan for AIDS Relief-supported HIV clinic...
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27987086/a-latent-class-analysis-of-seroadaptation-among-gay-and-bisexual-men
#17
Kiffer G Card, Nathan J Lachowsky, Zishan Cui, Allison Carter, Heather Armstrong, Susan Shurgold, David Moore, Robert S Hogg, Eric A Roth
Initial research into seroadaptive strategies suggests that, individually, they are potentially effective behavioral methods to reduce risk of HIV transmission. Combining strategies, therefore, has the potential to increase risk reduction. The aim of this study was to determine how gay and bisexual men (GBM) combine strategies. To this end, a total of 774 sexually active GBM, aged ≥16 years, in Metro Vancouver, Canada, were recruited. Grouped by self-reported HIV status, latent class analysis of self-reported condom use, strategic positioning, anal sex avoidance, serosorting, viral-load sorting, and withdrawal were conducted...
December 16, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27987085/preferences-for-condomless-sex-in-sexually-explicit-media-among-black-african-american-men-who-have-sex-with-men-implications-for-hiv-prevention
#18
Kimberly M Nelson, Lisa A Eaton, Kristi E Gamarel
Accumulating evidence suggests that viewing sexually explicit media (SEM; i.e., pornography) may be related to the sexual behaviors of men who have sex with men (MSM). Furthermore, stereotypical depictions of Black/African American MSM engaging in sexual risk behaviors in SEM may serve to normalize condomless sex, reinforce low peer norms around condom use, and facilitate HIV risk taking among Black/African American MSM. Despite this evidence, very little is known about the correlates of SEM consumption among Black/African American MSM, including HIV risk behaviors and their relation to preferences for viewing condomless sex in SEM...
December 16, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27977387/exploring-the-role-of-sex-seeking-apps-and-websites-in-the-social-and-sexual-lives-of-gay-bisexual-and-other-men-who-have-sex-with-men-a-cross-sectional-study
#19
Kiffer G Card, Nathan J Lachowsky, Zishan Cui, Susan Shurgold, Maya Gislason, Jamie I Forrest, Ashleigh J Rich, David Moore, Eric Roth, Robert S Hogg
Background: The objective of this study was to explore the relationship between online sex-seeking, community/social attachment and sexual behaviour. Methods: Respondent-driven sampling was used to recruit 774 sexually active gay and bisexual men in Vancouver, Canada, aged ≥16 years. Multivariable logistic regression compared men who had used online sex-seeking apps/websites in the past 6 months (n=586) with those who did not (n=188). Results: Multivariable results showed that online sex seekers were more likely to be younger [adjusted odds ratio (aOR)=0...
December 16, 2016: Sexual Health
https://www.readbyqxmd.com/read/27977386/stigma-gay-men-and-biomedical-prevention-the-challenges-and-opportunities-of-a-rapidly-changing-hiv-prevention-landscape
#20
Graham Brown, William Leonard, Anthony Lyons, Jennifer Power, Dirk Sander, William McColl, Ronald Johnson, Cary James, Matthew Hodson, Marina Carman
Improvements in biomedical technologies, combined with changing social attitudes to sexual minorities, provide new opportunities for HIV prevention among gay and other men who have sex with men (GMSM). The potential of these new biomedical technologies (biotechnologies) to reduce HIV transmission and the impact of HIV among GMSM will depend, in part, on the degree to which they challenge prejudicial attitudes, practices and stigma directed against gay men and people living with HIV (PLHIV). At the structural level, stigma regarding gay men and HIV can influence the scale-up of new biotechnologies and negatively affect GMSM's access to and use of these technologies...
December 16, 2016: Sexual Health
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