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https://www.readbyqxmd.com/read/27930607/counseling-framework-for-hiv-serodiscordant-couples-on-the-integrated-use-of-antiretroviral-therapy-and-pre-exposure-prophylaxis-for-hiv-prevention
#1
Jennifer F Morton, Connie Celum, John Njoroge, Agnes Nakyanzi, Imeldah Wakhungu, Edna Tindimwebwa, Snaidah Ongachi, Eric Sedah, Emmanuel Okwero, Kenneth Ngure, Josephine Odoyo, Nulu Bulya, Jessica E Haberer, Jared M Baeten, Renee Heffron
BACKGROUND: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging, sensitive to the barriers and motivators to HIV treatment and prevention, is needed for widespread scale-up of this approach. METHODS: Within the Partners Demonstration Project, a prospective interventional project among 1013 serodiscordant couples in Kenya and Uganda, we offered ART to eligible HIV-positive partners and PrEP to HIV-negative partners before ART initiation and through the HIV-positive partner's first 6 months of ART use...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27923009/counseling-framework-for-hiv-serodiscordant-couples-on-the-integrated-use-of-antiretroviral-therapy-and-pre-exposure-prophylaxis-for-hiv-prevention
#2
Jennifer F Morton, Connie Celum, John Njoroge, Agnes Nakyanzi, Imeldah Wakhungu, Edna Tindimwebwa, Snaidah Ongachi, Eric Sedah, Emmanuel Okwero, Kenneth Ngure, Josephine Odoyo, Nulu Bulya, Jessica E Haberer, Jared M Baeten, Renee Heffron
BACKGROUND: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging, sensitive to the barriers and motivators to HIV treatment and prevention, is needed for widespread scale-up of this approach. METHODS: Within the Partners Demonstration Project, a prospective interventional project among 1013 serodiscordant couples in Kenya and Uganda, we offered ART to eligible HIV-positive partners and PrEP to HIV-negative partners before ART initiation and through the HIV-positive partner's first 6 months of ART use...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27922719/markov-mixed-effects-modeling-using-electronic-adherence-monitoring-records-identifies-influential-covariates-to-hiv-preexposure-prophylaxis
#3
Kumpal Madrasi, Ayyappa Chaturvedula, Jessica E Haberer, Mark Sale, Michael J Fossler, David Bangsberg, Jared M Baeten, Connie Celum, Craig W Hendrix
Adherence is a major factor in the effectiveness of preexposure prophylaxis (PrEP) for HIV prevention. Modeling patterns of adherence helps to identify influential covariates of different types of adherence as well as to enable clinical trial simulation so that appropriate interventions can be developed. We developed a Markov mixed-effects model to understand the covariates influencing adherence patterns to daily oral PrEP. Electronic adherence records (date and time of medication bottle cap opening) from the Partners PrEP ancillary adherence study with a total of 1147 subjects were used...
December 6, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27905014/sexual-venue-choice-and-sexual-risk-taking-among-substance-using-men-who-have-sex-with-men
#4
Joshua A Rusow, Jesse B Fletcher, Cathy J Reback
Commercial sex venues (CSVs) and public sex environments (PSEs) offer men who have sex with men (MSM) sexual privacy and anonymity. Sociodemographic characteristics (e.g., race/ethnicity, sexual identity, age, HIV status) are correlated with individuals' choice of sexual venue, potentially suggesting environmental associations with both sociodemographics and sexual risk. From March 2005 through March 2012, 1298 substance-using MSM provided information on their most recent sexual encounter; iterative logit models estimated associations between sociodemographics and sexual venue, and/or whether sexual venue was associated with sexual risk-taking while controlling for sociodemographics...
November 30, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27900502/values-and-preferences-on-the-use-of-oral-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-multiple-populations-a-systematic-review-of-the-literature
#5
Florence M Koechlin, Virginia A Fonner, Sarah L Dalglish, Kevin R O'Reilly, Rachel Baggaley, Robert M Grant, Michelle Rodolph, Ioannis Hodges-Mameletzis, Caitlin E Kennedy
Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP...
November 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27898566/antiretroviral-therapy-initiation-is-not-associated-with-risky-sexual-behavior-among-heterosexual-human-immunodeficiency-virus-infected-persons-in-serodiscordant-partnerships
#6
Andrew Mujugira, Connie Celum, Kenneth Ngure, Katherine K Thomas, Elly Katabira, Jared M Baeten
BACKGROUND: Few prospective studies have assessed whether antiretroviral therapy (ART) use is associated with changes in sexual risk behavior of human immunodeficiency virus (HIV)-infected persons in known HIV-serodiscordant partnerships. METHODS: We conducted a longitudinal analysis of HIV-infected persons with known uninfected partners enrolled in the Partners Pre-Exposure Prophylaxis Study in Kenya and Uganda. Antiretroviral therapy use and self-reported sexual behavior were ascertained every 3 months...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27893598/acceptability-and-effectiveness-of-assisted-human-immunodeficiency-virus-partner-services-in-mozambique-results-from-a-pilot-program-in-a-public-urban-clinic
#7
R Serene Myers, Caryl Feldacker, Freide Cesár, Zulmira Paredes, Gerito Augusto, Chadreque Muluana, Sinesia Citao, Catarina Mboa-Ferrao, Esmeralda Karajeanes, Matthew R Golden
BACKGROUND: Assisted partner services (APS) involves offering persons with human immunodeficiency virus (HIV) assistance notifying and testing their sex partners. Assisted partner services is rarely available in sub-Saharan Africa. We instituted a pilot APS program in Maputo, Mozambique. METHODS: Between June and September 2014, community health workers (CHWs) offered APS to persons with newly diagnosed HIV (index patients [IPs]). Community health workers interviewed IPs at baseline, 4 and 8 weeks...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27852641/does-age-matter-sexual-event-level-analysis-of-age-disparate-sexual-partners-among-gay-bisexual-and-other-men-who-have-sex-with-men-gbm-in-vancouver-canada
#8
K Closson, N J Lachowsky, Z Cui, S Shurgold, P Sereda, A Rich, D M Moore, E A Roth, R S Hogg
BACKGROUND: To determine factors associated with age-disparate sexual partners among Vancouver gay, bisexual and other men who have sex with men (GBM). METHODS: Sexually active GBM aged ≥16 years were recruited from February 2012 to February 2014. Participants self-completed a questionnaire on demographics, attitudes and sexual behaviour and substance use at last sexual event with five most recent partners. Two generalised linear mixed models identified factors associated with: (1) 'same-age' (referent), 'younger' or 'much-younger' and (2) 'same-age' (referent), 'older' or 'much-older' partners...
November 16, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27832759/-people-say-that-we-are-already-dead-much-as-we-can-still-walk-a-qualitative-investigation-of-community-and-couples-understanding-of-hiv-serodiscordance-in-rural-uganda
#9
Jiho Kim, Mastula Nanfuka, David Moore, Murisho Shafic, Maureen Nyonyitono, Josephine Birungi, Florence Galenda, Rachel King
BACKGROUND: Stable, co-habiting HIV serodiscordant couples are a key population in terms of heterosexual transmission in sub-Saharan Africa. Despite the wide availability of antiretroviral treatment and HIV educational programs, heterosexual transmission continues to drive the HIV epidemic in Africa. To investigate some of the factors involved in transmission or maintenance of serodiscordant status, we designed a study to examine participants' understanding of HIV serodiscordance and the implications this posed for their HIV prevention practices...
November 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27777220/what-level-of-risk-compensation-would-offset-the-preventive-effect-of-early-antiretroviral-therapy-simulations-from-the-temprano-trial
#10
Kévin Jean, Marie-Claude Boily, Christine Danel, Raoul Moh, Anani Badjé, Annabel Desgrées-du-Loû, Serge Eholié, France Lert, Rosemary Dray-Spira, Xavier Anglaret, Eric Ouattara
Whether risk compensation could offset the preventive effect of early initiation of antiretroviral therapy (ART) on human immunodeficiency virus (HIV) transmission remains unknown. Using virological and behavioral data collected 12 months after inclusion in the TEMPRANO randomized trial of early ART (Abidjan, Côte d'Ivoire, 2009-2012), we estimated the risk of HIV transmission and compared it between the intervention (early ART; n = 490) and control (deferred ART; n = 467) groups. We then simulated increases in various sexual risk behaviors in the intervention group and estimated the resulting preventive effect...
October 24, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27751179/use-of-a-risk-scoring-tool-to-identify-higher-risk-hiv-1-serodiscordant-couples-for-an-antiretroviral-based-hiv-1-prevention-intervention
#11
Elizabeth M Irungu, Renee Heffron, Nelly Mugo, Kenneth Ngure, Elly Katabira, Nulu Bulya, Elizabeth Bukusi, Josephine Odoyo, Stephen Asiimwe, Edna Tindimwebwa, Connie Celum, Jared M Baeten
BACKGROUND: Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) reduce HIV-1 transmission within heterosexual HIV-1 serodiscordant couples. Prioritizing couples at highest HIV-1 transmission risk for ART and PrEP would maximize impact and minimize costs. METHODS: The Partners Demonstration Project is an open-label, delivery study of integrated PrEP and ART for HIV-1 prevention among high risk HIV-1 serodiscordant couples in Kenya and Uganda. We evaluated the feasibility of using a validated risk score that weighs a combination of easily measurable factors (age, children, marital status, male circumcision status, condom use, plasma HIV-1 levels) to identify couples at highest risk for HIV-1 transmission for enrollment...
October 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27651184/-pre-exposure-prophylaxis-for-hiv-clinical-practice-and-challenge
#12
Shen Yinzhong, L U Hongzhou
Antiretroviral therapy (ART) can not only turn HIV infection from a fatal disease into a treatable chronic disease, but also reduce HIV transmission among high-risk people. In recent years the concept "treatment as prevention" has been accepted by the public. More and more studies have shown that pre-exposure prophylaxis (PrEP) for HIV can effectively reduce the spreading of HIV in high-risk populations. Clinical trials have also shown that PrEP is safe, and can effectively prevent high-risk people from HIV infection...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27646852/congruence-of-home-social-and-sex-neighborhoods-among-men-who-have-sex-with-men-nycm2m-study
#13
Beryl A Koblin, James E Egan, Vijay Nandi, Jordan M Sang, Magdalena Cerdá, Hong-Van Tieu, Danielle C Ompad, Donald R Hoover, Victoria Frye
Substantial literature demonstrates the influence of the neighborhood environment on health behaviors and outcomes. But limited research examines on how gay and bisexual men experience and exist in various geographic and virtual spaces and how this relates to their sexual behavior. New York City Men 2 Men (NYCM2M) was a cross-sectional study designed to identify neighborhood-level characteristics within the urban environment that influence sexual risk behaviors, substance use, and depression among men who have sex with men (MSM) living in NYC...
September 19, 2016: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/27637499/erectile-dysfunction-medication-prescription-and-condomless-intercourse-in-hiv-infected-men-who-have-sex-with-men-in-the-united-states
#14
Xia Lin, Christine L Mattson, Mark Freedman, Jacek Skarbinski
Using nationally representative data, we assessed the prevalence of erectile dysfunction medication (EDM) prescription, and its association with insertive condomless anal intercourse (CAI) with an HIV-serodiscordant partner among sexually-active HIV-infected men who have sex with men (MSM) receiving medical care in the United States. Overall, 14 % (95 % CI 12-16) were prescribed EDM and 21 % (95 % CI 19-23) engaged in serodiscordant CAI. MSM who were prescribed EDM were more likely to engage in insertive CAI with a serodiscordant casual partner than those not prescribed EDM after adjusting for illicit drug use before or during sex (adjusted prevalence ratio = 1...
September 16, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27570578/attachment-orientation-and-sexual-risk-behaviour-among-young-black-gay-and-bisexual-men
#15
Stephanie H Cook, Daphne C Watkins, Benjamin Calebs, Patrick A Wilson
This mixed methods study used an explanatory sequential design to examine the relationship between attachment and sexual behavior among young Black gay and bisexual men (YBGBM). Cross sectional online surveys and sex diaries were completed by a sample of YBGBM in New York City (n = 153) to assess the association between adult attachment insecurity and sexual risk behavior. The Experiences in Close Relationships Scale-Revised (ECR-R) was used to assess three types of adult attachment (i.e., secure, anxious, and avoidant)...
2016: Psychology and Sexuality
https://www.readbyqxmd.com/read/27562905/a-dyadic-behavioral-intervention-to-optimize-same-sex-male-couples-engagement-across-the-hiv-care-continuum-development-of-and-protocol-for-an-innovative-couples-based-approach-partner-steps
#16
Angela Robertson Bazzi, Kirkpatrick B Fergus, Rob Stephenson, Catherine A Finneran, Julia Coffey-Esquivel, Marco A Hidalgo, Sam Hoehnle, Patrick S Sullivan, Robert Garofalo, Matthew J Mimiaga
BACKGROUND: An estimated one- to two-thirds of new human immunodeficiency virus (HIV) infections among US men who have sex with men (MSM) occur within the context of primary partnerships. Thus, HIV interventions that recognize and harness the power of relationships are needed. Increasingly, HIV prevention efforts are being directed toward improving engagement across the HIV care continuum from testing to linkage to care, antiretroviral therapy (ART) adherence, engagement in care, and viral suppression...
August 25, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27552090/integrated-delivery-of-antiretroviral-treatment-and-pre-exposure-prophylaxis-to-hiv-1-serodiscordant-couples-a-prospective-implementation-study-in-kenya-and-uganda
#17
Jared M Baeten, Renee Heffron, Lara Kidoguchi, Nelly R Mugo, Elly Katabira, Elizabeth A Bukusi, Stephen Asiimwe, Jessica E Haberer, Jennifer Morton, Kenneth Ngure, Nulu Bulya, Josephine Odoyo, Edna Tindimwebwa, Craig Hendrix, Mark A Marzinke, Norma C Ware, Monique A Wyatt, Susan Morrison, Harald Haugen, Andrew Mujugira, Deborah Donnell, Connie Celum
BACKGROUND: Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical trials. We conducted a prospective implementation study to understand the feasibility and effectiveness of these interventions in delivery settings. METHODS AND FINDINGS: Between November 5, 2012, and January 5, 2015, we enrolled and followed 1,013 heterosexual HIV-1-serodiscordant couples in Kenya and Uganda in a prospective implementation study...
August 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27551959/the-association-between-hiv-disclosure-status-and-perceived-barriers-to-care-faced-by-women-living-with-hiv-in-latin-america-china-central-eastern-europe-and-western-europe-canada
#18
Mona Loutfy, Margaret Johnson, Sharon Walmsley, Anna Samarina, Patricia Vasquez, He Hao-Lan, Tshepiso Madihlaba, Marisol Martinez-Tristani, Jean van Wyk
Generally, women are less likely than men to disclose their HIV status. This analysis examined the relationship between HIV disclosure and (1) perceived barriers to care and (2) quality of life (QoL) for women with HIV. The ELLA (EpidemioLogical study to investigate the popuLation and disease characteristics, barriers to care, and quAlity of life for women living with HIV) study enrolled HIV-positive women aged ≥18 years. Women completed the 12-item Barriers to Care Scale (BACS) questionnaire. QoL was assessed using the Health Status Assessment...
September 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27535763/how-do-hiv-negative-individuals-in-sub-saharan-africa-change-their-sexual-risk-behaviour-upon-learning-their-serostatus-a-systematic-review
#19
Sanjeev Ramachandran, Sharmistha Mishra, Natalie Condie, Michael Pickles
OBJECTIVE: To determine whether, and how, sexual behaviour of HIV-negative individuals in sub-Saharan Africa (SSA) changes upon learning their serostatus. METHODS: We systematically reviewed the published literature using EMBASE and Medline to search for publications between 2004 and 2014. We included studies that quantified behaviour change (condom use, number of sexual partners or sex acts) following an HIV test in HIV-negative adults in SSA, and extracted relevant data including study characteristics and measurement type...
August 17, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27532476/treatment-as-prevention-characterization-of-partner-infections-in-the-hiv-prevention-trials-network-052-trial
#20
Susan H Eshleman, Sarah E Hudelson, Andrew D Redd, Ronald Swanstrom, San-San Ou, Xinyi Cindy Zhang, Li-Hua Ping, Estelle Piwowar-Manning, Stephen F Porcella, Matthew F Sievers, Craig A Martens, Daniel Bruno, Elena Dukhovlinova, Marybeth McCauley, Theresa Gamble, Jessica M Fogel, Devin Sabin, Thomas C Quinn, Laurence Gunde, Madalitso Maliwichi, Nehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves de Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q Chen, James P Hughes, Myron S Cohen
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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