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https://www.readbyqxmd.com/read/28550385/metastatic-breast-carcinoma-to-the-superior-oblique-in-a-male
#1
Yao Wang, Pradeep Mettu, Amanda Maltry, Andrew Harrison, Ali Mokhtarzadeh
We describe a case of breast cancer metastatic to the superior oblique, in a male. The patient was a 66-year-old Caucasian male with a history of stage IIIB rectal adenocarcinoma and stage IIA left breast carcinoma diagnosed 12 years and 5 years prior, respectively, who presented with headaches and intermittent diplopia. He underwent left total mastectomy with sentinel lymph node biopsy 6 years prior, which showed ER/PR+, HER2/neu-, moderately-differentiated, infiltrating ductal carcinoma with 3/14 positive nodes...
May 26, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28550356/orbital-malignant-lesions-in-adults-multiparametric-mr-imaging
#2
Bo Sun, Liyuan Song
PURPOSE: To assess the benefit of combining diffusion-weighted imaging and dynamic contrast-enhanced (DCE) MR imaging in the preoperative evaluation of orbital lymphoma and other malignancies in adults. MATERIALS AND METHODS: This retrospective study was institutional review board-approved and informed consent was waived. Pretreatment MR imaging was performed in 52 patients with malignant orbital lesions. Apparent diffusion coefficient (ADC) and DCE MR parameters were evaluated in 30 patients with orbital lymphoma and 22 patients with other orbital malignancies...
May 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28549965/microrna-101-in-the-ventrolateral-orbital-cortex-vlo-modulates-depressive-like-behaviors-in-rats-and-targets-dual-specificity-phosphatase-1-dusp1
#3
Yan Zhao, Shuang Wang, Zheng Chu, Yonghui Dang, Juanxia Zhu, Xingli Su
Long-term exposure to stress plays a key role in the pathogenesis of major depression. Recently, the ventrolateral orbital cortex (VLO) has received considerable attention for its role in the antidepressant response. However, the mechanisms underlying stress response in the VLO remain largely elusive. MiR-101 has been implicated in regulating multiple neurological processes. The present study used the chronic unpredictable mild stress (CUMS) rat model to investigate the expression of miR-101 in the VLOs of rat brains and the possible relevance of miR-101 to depression...
May 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28549679/one-should-avoid-retro-orbital-pharmacokinetic-sample-collections-for-intranasal-dosing-in-rats-illustration-of-spurious-pharmacokinetics-generated-for-anti-migraine-drugs-zolmitriptan-and-eletriptan
#4
Harilal Patel, Prakash Patel, Nirav Modi, Shaival Shah, Ashok Ghoghari, Bhavesh Variya, Ritu Laddha, Dipesh Baradia, Nitin Dobaria, Pavak Mehta, Nuggehally R Srinivas
Because of the avoidance of first pass metabolic effects due to direct and rapid absorption with improved permeability, intranasal route represents a good alternative for extravascular drug administration. The aim of the study was to investigate the intranasal pharmacokinetics of two anti-migraine drugs (zolmitriptan and eletriptan), using retro-orbital sinus and jugular vein sites sampling. In a parallel study design, healthy male Sprague-Dawley (SD) rats aged between 8 and 12weeks were divided into groups (n=4 or 5/group)...
May 23, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28549557/aberrant-distribution-of-the-trochlear-nerve-a-cadaveric-study-supported-by-immunohistochemistry
#5
Kojiro Takezawa, Grant Townsend, Jim Manavis, Mounir Ghabriel
The trochlear nerve is generally considered to be a purely motor nerve supplying one extraocular muscle, the superior oblique. In the current study, 28 orbits were dissected and in one orbit (3.6%), the trochlear nerve divided into two main branches. The medial branch followed the classical course, entered the superior oblique muscle and was presumed to be motor in function. However, before entering the muscle, it partially fused with the frontal nerve, and gave a bundle of nerve fibres to the frontal nerve...
May 23, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28549352/eye-abduction-reduces-but-does-not-eliminate-competition-in-the-oculomotor-system
#6
Paul J Boon, Jan Theeuwes, Artem V Belopolsky
Although it is well established that there is a tight coupling between covert attention and the eye movement system there is an ongoing controversy whether this relationship is functional. Previous studies demonstrated that disrupting the ability to execute an eye movement interferes with the allocation of covert attention. One technique that prevents the execution of an eye movement involves the abduction of the eye in the orbit while presenting the stimuli outside of the effective oculomotor range (Craighero, Nascimben, & Fadiga, 2004)...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28549318/brain-neurodevelopmental-markers-related-to-the-deficit-subtype-of-schizophrenia
#7
Tsutomu Takahashi, Yoichiro Takayanagi, Yumiko Nishikawa, Mihoko Nakamura, Yuko Komori, Atsushi Furuichi, Mikio Kido, Daiki Sasabayashi, Kyo Noguchi, Michio Suzuki
Deficit schizophrenia is a homogeneous subtype characterized by a trait-like feature of primary and prominent negative symptoms, but the etiologic factors related to this specific subtype remain largely unknown. This magnetic resonance imaging study aimed to examine gross brain morphology that probably reflects early neurodevelopment in 38 patients with deficit schizophrenia, 37 patients with non-deficit schizophrenia, and 59 healthy controls. Potential brain neurodevelopmental markers investigated in this study were the adhesio interthalamica (AI), cavum septi pellucidi (CSP), and surface morphology (i...
May 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28549034/mantle-cell-lymphoma-with-hodgkin-and-reed-sternberg-cells-review-with-illustrative-case
#8
Steven Kramer, Guldeep Uppal, Zi-Xuan Wang, Jerald Z Gong
Non-Hodgkin lymphoma may occasionally contain large transformed cells resembling Hodgkin and Reed-Sternberg cells (HRS cells). We report a 63-year-old man with HRS cells in a recurrent mantle cell lymphoma (MCL). The patient initially presented with orbital MCL and recurred after 8 years with widespread involvement. The HRS cells were present in the recurrent disease but not in the initial orbital lesions, suggesting a transformed event after a prolonged disease course. Morphologically, the HRS cells were single cells and small clusters among the MCL cells and were frequently accompanied by histiocytes but without eosinophils or other inflammatory cells...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28549018/intimate-partner-violence-in-ophthalmology-a-global-call-to-action
#9
Ali R Cohen, Lynette M Renner, Erin M Shriver
PURPOSE OF REVIEW: Intimate partner violence (IPV) is a leading cause of death and disability worldwide. Despite increasing public awareness of IPV, little information is available regarding the prevalence, associated injury patterns, and impact of IPV as a mechanism of ocular and orbital trauma. The purpose of this review is to summarize the literature regarding the impact of IPV in ophthalmology and provide team members with guidance on appropriate practices for screening and referral...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28549017/diagnosis-of-enlarged-extraocular-muscles-when-and-how-to-biopsy
#10
Ilse Mombaerts, Geoffrey E Rose, David H Verity
PURPOSE OF REVIEW: To review current knowledge regarding diagnosis of nonthyroid orbital disorders with extraocular muscle enlargement. RECENT FINDINGS: Recent publications have focused on immunoglobulin G4-related disease as a possible cause of enlarged extraocular muscles, on patterns of strabismus that raise a clinical suspicion of intramuscular lymphoma, and on surgical techniques to access the muscles for tissue biopsy. SUMMARY: With enlarged extraocular muscles, features to distinguish between competing diagnostic possibilities are based on imaging in the context of history and clinical signs...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28548827/dynamic-disorder-and-electronic-structures-of-electron-precise-dianionic-diboranes-insights-from-solid-state-multinuclear-magnetic-resonance-spectroscopy
#11
Y T Angel Wong, Johannes Landmann, Maik Finze, David L Bryce
The J(11B, 11B) coupling constants of various salts of the electron-precise hexacyanodiborane(6) dianion, [B2(CN)6]2-, were obtained using 11B double-quantum filtered (DQF) J-resolved solid-state nuclear magnetic resonance (SSNMR) spectroscopy. Our results show that the magnitude of the DQF J splitting is influenced by both the crystallo-graphic symmetry of the system and the presence of dynamics. The splittings are amplified by a factor of 3 as compared to the corresponding theoretical J coupling constants for cases where 1) there is an absence of dynamics but the boron pairs are crystallographically equivalent, or 2) the boron pairs are crystallographically inequivalent but are rendered magnetically equivalent on the timescale of the experiment due to dynamic disorder, which was identified by 11B and 13C SSNMR experiments...
May 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28548706/45-gy-is-not-sufficient-radiotherapy-dose-for-group-iii-orbital-embryonal-rhabdomyosarcoma-after-less-than-complete-response-to-12-weeks-of-arst0331-chemotherapy-a-report-from-the-soft-tissue-sarcoma-committee-of-the-children-s-oncology-group
#12
Ralph P Ermoian, John Breneman, David O Walterhouse, Yueh-Yun Chi, Jane Meza, James Anderson, Douglas S Hawkins, Andrea A Hayes-Jordan, David M Parham, Torunn I Yock, Sarah S Donaldson, Suzanne L Wolden
BACKGROUND: Recent Children's Oncology Group (COG) trials tested the efficacy of reduced therapy in an effort to lessen late effects compared to the Intergroup Rhabdomyosarcoma Study (IRS) IV regimen with associated hematologic and hepatic toxicity, and infertility. Here, we analyze the efficacy of 45 Gray (Gy) local radiotherapy (RT) in patients with Group III orbital embryonal rhabdomyosarcoma (ERMS) enrolled on the COG low-risk study ARST0331. PROCEDURE: Sixty-two patients with Group III orbital ERMS were treated on ARST0331 with four cycles of vincristine (VCR), dactinomycin (DACT), and cyclophosphamide (CPM; VAC, total cumulative CPM dose 4...
May 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28548625/acute-procedural-outcomes-of-orbital-atherectomy-for-the-treatment-of-common-femoral-artery-disease-sub-analysis-of-the-confirm-registries
#13
Michael S Lee, Daniel Heikali, Jihad Mustapha, George Adams, Ehtisham Mahmud
This analysis compared the angiographic outcomes of patients treated with orbital atherectomy for calcified common femoral artery (CFA) and superficial femoral artery (SFA) disease. The ideal revascularization strategy for CFA disease is unknown. Endarterectomy has been considered the standard of care for CFA disease for over 50 years. Endovascular intervention is becoming more commonly used to revascularize the CFA given the advances in technology and the less invasive nature of the procedure. Patient demographics, lesion characteristics, and procedure data for all CONFIRM patients with at least one CFA lesion location ( n=147 patients; n=200 lesions) were compared to patients with at least one SFA lesion location ( n=1508 patients; n=2367 lesions)...
May 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28548552/serum-cyr61-is-associated-with-disease-activity-in-graves-orbitopathy
#14
Young Jun Woo, Yuri Seo, Jin Joo Kim, Ji Won Kim, Yil Park, Jin Sook Yoon
PURPOSE: To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO). METHODS: Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction...
May 26, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28548531/hunting-the-gluon-orbital-angular-momentum-at-the-electron-ion-collider
#15
Xiangdong Ji, Feng Yuan, Yong Zhao
Applying the connection between the parton Wigner distribution and orbital angular momentum (OAM), we investigate the probe of the gluon OAM in hard scattering processes at the planned electron-ion collider. We show that the single longitudinal target-spin asymmetry in the hard diffractive dijet production is very sensitive to the gluon OAM distribution. The associated spin asymmetry leads to a characteristic azimuthal angular correlation of sin(ϕ_{q}-ϕ_{Δ}), where ϕ_{Δ} and ϕ_{q} are the azimuthal angles of the proton momentum transfer and the relative transverse momentum between the quark-antiquark pair...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548518/density-functional-theory-of-the-fractional-quantum-hall-effect
#16
Jianyun Zhao, Manisha Thakurathi, Manish Jain, Diptiman Sen, J K Jain
A conceptual difficulty in formulating the density-functional theory of the fractional quantum Hall effect is that while in the standard approach the Kohn-Sham orbitals are either fully occupied or unoccupied, the physics of the fractional quantum Hall effect calls for fractionally occupied Kohn-Sham orbitals. This has necessitated averaging over an ensemble of Slater determinants to obtain meaningful results. We develop an alternative approach in which we express and minimize the grand canonical potential in terms of the composite fermion variables...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548512/quantum-fluctuations-along-symmetry-crossover-in-a-kondo-correlated-quantum-dot
#17
Meydi Ferrier, Tomonori Arakawa, Tokuro Hata, Ryo Fujiwara, Raphaëlle Delagrange, Richard Deblock, Yoshimichi Teratani, Rui Sakano, Akira Oguri, Kensuke Kobayashi
Universal properties of entangled many-body states are controlled by their symmetry and quantum fluctuations. By the magnetic-field tuning of the spin-orbital degeneracy in a Kondo-correlated quantum dot, we have modified quantum fluctuations to directly measure their influence on the many-body properties along the crossover from SU(4) to SU(2) symmetry of the ground state. High-sensitive current noise measurements combined with the nonequilibrium Fermi liquid theory clarify that the Kondo resonance and electron correlations are enhanced as the fluctuations, measured by the Wilson ratio, increase along the symmetry crossover...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548511/solitons-in-bose-einstein-condensates-with-helicoidal-spin-orbit-coupling
#18
Yaroslav V Kartashov, Vladimir V Konotop
We report on the existence and stability of freely moving solitons in a spatially inhomogeneous Bose-Einstein condensate with helicoidal spin-orbit (SO) coupling. In spite of the periodically varying parameters, the system allows for the existence of stable propagating solitons. Such states are found in the rotating frame, where the helicoidal SO coupling is reduced to a homogeneous one. In the absence of the Zeeman splitting, the coupled Gross-Pitaevskii equations describing localized states feature many properties of the integrable systems...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548172/a-theoretical-study-on-anion-sensing-mechanism-of-multi-phosphonium-triarylboranes-intramolecular-charge-transfer-and-configurational-changes
#19
Haamid R Bhat, Prakash C Jha
The binding selectivity and recognition mechanism of a series of mono-, di- and triphosphonium substituted triarylboranes: (4-(dimesitylboryl)-3,5-dimethylphenyl)phosphonium ([Mes2BAr(P)](+), 1), 1,1'-mesitylboranediylbis(3,5-dimethylphenyl)phosphonium ([MesBAr(P)2](2+), 2) and 1,1',1''-boranetriyltris(3,5-dimethylphenyl)phosphonium ([BAr(P)3](3+), 3) where Ar(P) = 4-(H3P)-2,6-Me2-C6H2, for various anions has been investigated by employing density functional theory (DFT) and time dependent-density functional theory (TD-DFT) methods...
May 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28547930/orbit-technique-in-malrotation-with-non-obstructive-volvulus-a-novel-technique-of-devolvulation
#20
Sundeep Kisku
INTRODUCTION: Volvulus may be noted in up to two-thirds of cases involving malrotation beyond infancy. Laparoscopic devolvulation has been described as a frustrating procedure because of restricted visualization. Here, a setup and technique that address these concerns are proposed. MATERIALS AND SURGICAL TECHNIQUE: Three boys (median age: 7 years) who had been diagnosed preoperatively with malrotation underwent laparoscopic exploration and devolvulation for volvulus found intraoperatively...
May 2017: Asian Journal of Endoscopic Surgery
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