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Nasal sinus

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https://www.readbyqxmd.com/read/29035825/effect-of-a-combination-of-mometasone-furoate-levofloxacin-and-retinyl-palmitate-with-an-in-situ-gel-forming-nasal-delivery-system-on-nasal-mucosa-damage-repair-in-an-experimental-rabbit-model
#1
Fadlullah Aksoy, Remzi Dogan, Orhan Ozturan, Ebru Altuntas, Fatma Gülgün Yener, Gulactı Topcu, Beril Guler
BACKGROUND: In this study a combination of Mometasone Furoate (MF)+Levofloxacin hemihydrate (LH)+Retinyl palmitate (RP) with an in situ gel-forming delivery system was evaluated at different stages of nasal mucosal damage repair in a rabbit maxillary sinus model. METHODS: In this study, 28 rabbits were included and assigned randomly to four groups. In all rabbits, a standard ostium was opened in the medial wall of the maxillary sinus by using a drill. Two different subsequently prepared gels with an in situ gel-forming delivery system were used...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29026829/aggressive-combined-medical-and-surgical-management-of-mucormycosis-results-in-disease-eradication-in-2-pediatric-patients
#2
Haley F M Augustine, Colin White, James Bain
Rhinocerebral mucormycosis is an acute, rapidly fatal, fungal infection, classically involving the nasal mucosa and paranasal sinuses. It is an aggressive, opportunistic infection that frequently progresses to involve the orbit and cerebrum. Cerebral extension in immunocompromised patients is almost universally fatal. There are limited data on mucormycosis in pediatric immunocompromised patients in the literature, with only few reports on rhinocerebral involvement. The immunocompromised patients described in this report presented with suspected periorbital and nasal cellulitis, progressing rapidly to necrotic changes in nasal tissue and oral palatal mucosa...
August 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29024522/in-vitro-safety-evaluation-of-human-nasal-epithelial-cell-monolayers-exposed-to-carrageenan-sinus-wash
#3
Mahnaz Ramezanpour, Jae Murphy, Jason L P Smith, Sarah Vreugde, Alkis James Psaltis
BACKGROUND: Carrageenans have shown to reduce the viral load in nasal secretions and lower the incidence of secondary infections in children with common cold. Despite the widespread use of carrageenans in topical applications, the effect of carrageenans on the sinonasal epithelial barrier has not been elucidated. We investigate the effect of different carrageenans on the sinonasal epithelial barrier and inflammatory response in vitro. METHODS: Iota and Kappa carrageenan delivered in saline irrigation solutions applied to air-liquid interface (ALI) cultures of primary human nasal epithelial cells from chronic rhinosinusitis patients and controls...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29024448/isolated-sphenoid-sinus-opacifications-a-systematic-review-and-meta-analysis
#4
REVIEW
William J Moss, Andrey Finegersh, Aria Jafari, Bharat Panuganti, Charles S Coffey, Adam DeConde, Jacob Husseman
BACKGROUND: Isolated sphenoid sinus opacifications (ISSOs) represent a relatively uncommon disease with the potential for serious complications. To better understand this disease, we performed a systematic review to further characterize the underlying pathologies, associated symptoms, and treatment outcomes of patients with ISSOs. METHODS: A systematic review of ISSO case series was performed utilizing the Medline, Embase, Web of Science, and Cochrane databases in accordance with guidelines established by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29023297/evaluation-of-sinonasal-change-after-lefort-i-osteotomy-using-cone-beam-computed-tomography-images
#5
Seung Woo Baeg, Yun Pyo Hong, Dong Hyun Cho, Jeong Keun Lee, Seung Il Song
Orthognathic surgery including Le Fort I osteotomy involves changes in the nasal septum and maxillary sinus. This study assesses nasal septum changes after Le Fort I osteotomy using cone beam computed tomography images and evaluates mucosal changes in the maxillary sinus after the surgery.This was a retrospective study of 33 patients who underwent orthognathic surgery including Le Fort I osteotomy. To assess the maxillary sinus, changes in the mucosa of the maxillary sinus were analyzed by volume and geometry...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29018504/hmgb1-in-the-pathogenesis-of-nasal-inflammatory-diseases-and-its-inhibition-as-new-therapeutic-approach-a-review-from-the-literature
#6
REVIEW
Luisa Maria Bellussi, Serena Cocca, Giulio Cesare Passali, Desideri Passali
Introduction  This study is a systematic review on recent developments about the importance of HMGB1 protein in the pathogenesis of rhino-sinusal inflammatory diseases. We also report data on the use of 18-β-glycyrrhetic acid (GA), which has been shown able to inhibit the pro-inflammatory activities of HMGB1, in young patients affected by allergic rhinitis and complaining of nasal obstruction as main symptom. Objectives  The objective of this study was to review the literature to demonstrate the importance of HMGB1 in the pathogenesis of nasal inflammatory disorders and understand whether the inhibition of this protein may be an efficacious and innovative therapeutic strategy for patients with rhino-sinusal inflammation...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28994339/intranasal-drug-delivery-devices-and-interventions-associated-with-post-operative-endoscopic-sinus-surgery
#7
Lari K Dkhar, Jim Bartley, David White, Ali Seyfoddin
This review article highlights the importance and advantages of the drug delivery systems applied via the nasal route after endoscopic sinus surgery (ESS) for patients suffering from chronic rhinosinusitis. After ESS, patients often require ongoing topical and systemic medication. To reduce the incidence of immediate and delayed post-surgical complications, a variety of temporary postoperative nasal interventions are currently used. However, newly developed intranasal drug delivery devices can enhance tissue recovery after endoscopic sinus surgery by releasing therapeutic drugs locally, while providing structural support to reduce tissue adhesion and scaring...
October 10, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28990423/dupilumab-for-the-treatment-of-asthma
#8
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Rosa Terracciano, Paolo Navalesi, Rosario Maselli, Girolamo Pelaia
Dupilumab is a fully human IgG4 monoclonal antibody directed against the α subunit of the interleukin (IL)-4 receptor (IL-4Rα). Since the activation of IL-4Rα is utilized by both IL-4 and IL-13 to mediate their pathophysiological effects, dupilumab behaves as a dual antagonist of these two sister cytokines, which blocks IL-4/IL-13-dependent signal transduction. Areas covered: Herein, the authors review the cellular and molecular pathways activated by IL-4 and IL-13, which are relevant to asthma pathobiology...
October 8, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28990012/impact-of-endoscopic-sinus-surgery-on-otologic-symptoms-associated-with-chronic-rhinosinusitis
#9
Neville W Teo, Jess C Mace, Timothy L Smith, Peter H Hwang
OBJECTIVE: To evaluate improvements in otologic symptoms after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS), and identify differences in symptoms, if any, between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyposis. STUDY DESIGN: Prospective multi-center observational cohort study. SETTING: Academic tertiary medical centers. SUBJECTS AND METHODS: Adults with medically recalcitrant CRS who elected ESS were enrolled in a prospective, multi-center, observational cohort study between March, 2011 and October, 2014...
March 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/28989817/medical-and-surgical-advancements-in-the-management-of-cystic-fibrosis-chronic-rhinosinusitis
#10
Kiranya E Tipirneni, Bradford A Woodworth
PURPOSE OF REVIEW: The purpose of this review is to provide otolaryngologists with the most up-to-date advancements in both the medical and surgical management of CF-related sinus disease. RECENT FINDINGS: Recent studies have supported more aggressive CRS management, often with a combination of both medical and surgical therapies. Comprehensive treatment strategies have been shown to reduce hospital admissions secondary to pulmonary exacerbations in addition to improving CRS symptoms...
March 2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28986000/the-effect-of-light-emitting-diode-590-830%C3%A2-nm-based-low-level-laser-therapy-on-posttraumatic-edema-of-facial-bone-fracture-patients
#11
Woo Yeol Baek, Il Hwan Byun, In Sik Yun, Jae Yoon Kim, Tai Suk Roh, Dae Hyun Lew, Young Seok Kim
PURPOSE: Posttraumatic edema in facial bone fracture patients may interfere with the operation field and delay the schedule. Thus, swiftly reducing the edema alleviates patient discomfort and advances the operation date. Ice packing and compression bandages are often used for such a purpose, but such methods are often inconvenient for the face. In this study, we aim to analyze the effect of light-emitting diode (LED) (590/830 nm)-based low-level laser therapy (LLLT) in posttraumatic edema in facial bone fracture patients...
September 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28980596/-certain-morphometric-characteristics-of-the-normal-maxillary-sinus
#12
D A Shcherbakov, A I Kryukov, V N Krasnozhen, A I Hukumatshoev, A I Karimova
Maxillary sinus is more than any other paranasal sinuses amenable to various pathological conditions that may require the surgical treatment. The objective of the present work was to study the age-related and the individual specific anatomical features of the walls of the maxillary sinus and to develop the principles of sinus surgery based on the results of the anthropometric studies. We analyzed the cone-beam CT scans obtained from 586 patients at the age varying from 5 to 60 years who were allocated to six different groups...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28980595/-differential-diagnostics-of-headache-associated-with-pathological-changes-in-the-nasal-cavity-and-paranasal-sinuses
#13
A I Kryukov, G Yu Tsarapkin, A S Tovmasyan, S G Arzamazov, Z O Zaoeva, A E Kishinevskii
Headache is not infrequently one of the major complaints in the patients visiting the otorhinolaryngologist's office. It was estimated to occur in 24% of the patients presenting with chronic sinusitis. The cause of headache may be pathological processes either in the nasal cavity or in the paranasal sinuses as well as a primary disorder in the nervous system. The present article is concerned with the peculiar features of rhinogenic headache and that of a different etiology. It was shown that the patients suffering from headache are in need not only of the obligatory otorhinolaryngological examination including endoscopy of the nasal cavity, X-ray study and, sometimes, specialized tests but also of neurological counseling...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28980594/-sintopy-of-the-distal-end-of-the-nasolacrimal-duct-detected-by-means-of-the-vector-analysis-of-the-ct-identified-anatomical-features-of-the-nasal-cavity
#14
G Yu Tsarapkin, A Yu Ivoylov, P L Chumakov, К M Fedotkina, E V Gorovaya, A V Artemieva-Karelova, E G Lapenko
The objective of the present work was to study syntopy of the distal end of the nasolacrimal duct based on the results of the vector analysis of the CT-identified anatomical features of the nasal cavity and the paranasal sinuses in 102 patients (204 nasolacrimal channels). The main criterion for inclusion in the study was the absence of traumatic injuries and inflammatory changes in the nasal cavity and the paranasal sinuses. X-ray studies of the distal end of the nasolacrimal duct (NLD), turbinate crest (crista conchalis), the edge of the nasal aperture, and the floor of the nasal cavity were carried out...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28980593/-cfd-simulation-of-the-air-flows-in-the-maxillary-sinus
#15
D A Shcherbakov, A I Krukov, V N Krasnozhen, Yu A Garskova, I I Saushin
This article summarizes the results of computer simulation of the air flows in the nasal cavity and the maxillary sinus by the computational fluid dynamics (CFD) method. The objective of the study was to apply the method of computational aerodynamics to simulate the air flows in the nasal cavity and the maxillary sinus under the normal conditions and after the surgical interventions on the middle nasal meatus. The normal air space of the nasal cavity and paranasal sinuses was simulated and the computer modeling of the main options for the surgical approach to the maxillary sinus through the middle nasal meatus was performed including balloon sinuplasty, functional endoscopic sinus surgery, and uncinate process mobilization...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28969258/esthesioneuroblastoma-presenting-with-bilateral-proptosis-and-blindness-in-a-child-a-case-report
#16
Mahdi Shahriari, Nader Shakibazad, Mehrpour Moradi
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-month-old girl with esthesioneuroblastoma in sphenoid and ethmoid sinus in a child presenting with bilateral proptosis, blindness, and irritability. The diagnosis was confirmed by histopathology.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965368/diagnostic-challenges-of-antrochoanal-polyps-a-review-of-sixty-one-cases
#17
N Choudhury, A Hariri, H Saleh, A Sandison
No abstract text is available yet for this article.
October 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28958373/expression-of-immunoglobulin-d-is-increased-in-chronic-rhinosinusitis
#18
Mofiyinfolu Sokoya, Vijay R Ramakrishnan, Daniel N Frank, Jeremy Rahkola, Anne Getz, Todd T Kingdom, Jennifer M Kofonow, Quyen Nguyen, Edward N Janoff
BACKGROUND: Immunoglobulin (Ig) D is largely localized to the upper airway and reacts with colonizing respiratory pathogens. OBJECTIVE: To determine whether chronic rhinosinusitis (CRS) is associated with increased IgD expression. METHODS: We performed immunofluorescent staining for cytoplasmic IgD, IgA, IgM, and surface plasma cell marker CD138 (syndecan-1) in sinus tissue of patients with CRS with and without nasal polyps (CRSwNP and CRSsNP, respectively) and control subjects without CRS (n = 6 each)...
October 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28957004/presence-of-avibacterium-paragallinarum-and-histopathologic-lesions-corresponds-with-clinical-signs-in-a-co-infection-model-with-gallibacterium-anatis
#19
Surya Paudel, Daniel Ruhnau, Patricia Wernsdorf, Dieter Liebhart, Michael Hess, Claudia Hess
Recently we demonstrated that co-infection with Avibacterium paragallinarum and Gallibacterium anatis leads to increased severity of clinical signs of infectious coryza in birds. The present study examined the interaction of these two pathogens in chickens by evaluation of histologic lesions in sinus infraorbitalis and nasal turbinates, applying a defined scoring scheme ranging from 0 to 3. Furthermore, for the first time, an in situ hybridization (ISH) technique was applied to detect A. paragallinarum in tissues...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28955676/a-rare-cause-of-intranasal-mass-bilateral-ectopic-nasal-teeth
#20
Hasan-Emre Koçak, Kadir Özdamar, Bekir Bilgi, Harun Acıpayam
INTRODUCTION: Ectopic teeth occur in a wide variety of sites, including the maxillary sinus, mandibular condyle, coronoid process, orbital, and nasal cavities. Reported symptoms and signs associated with nasal teeth include facial pain, external nasal deformities, foul-smelling rhinorrhea, recurrent epistaxis, and oronasal fistula. Ectopic teeth occurring bilaterally in the nasal cavity is very very rare. CASE REPORT: A bilateral intranasal ectopic teeth case, which is asymptomatic on the right side and symptomatic on the left side, is presented...
September 2017: Iranian Journal of Otorhinolaryngology
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