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Nasal sinus

Qinying Wang, Haihong Chen, Yang Yang, Bo Wang
OBJECTIVE: Adherence of pathogen to nasal mucosa and colonization is the first step of bacterial biofilm(BBF) formation in patients with chronic rhinosinusitis (CRS).Terminal sialic acids presenting on cell surface are potential targets for bacterial binding, thus may partly contribute to the pathogenesis of CRS. However, little has been published in this respect, the purpose of our study aimed to investigate the expression of sialic acids on the nasal mucosa in CRS patients and its possible effect on BBF formation...
June 12, 2018: Microbial Pathogenesis
Mathew P Gerard, Zoe G Glyphis, Christine Crawford, Anthony T Blikslager, Johan Marais
  African rhinoceros are poached for their horns using indiscriminate and aggressive methods. Rhinoceros that survive these attacks often have severe facial trauma, and treatment is limited by a lack of understanding and published information of the normal anatomy. This study was performed to investigate and describe the anatomy of the most commonly injured area of the head of the white rhinoceros ( Ceratotherium simum). Two white rhinoceros cadaver heads were imaged by computed tomography and grossly dissected...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Alessia Corrado, Monica Battle, Sarah K Wise, F Eun-Hyung Lee, David M Guidot, John M DelGaudio, Samuel A Molina, Joshua M Levy
BACKGROUND: The endocannabinoid system represents a highly conserved, innate signaling network with direct and indirect control of eicosanoid-mediated inflammation. Activation of the type 2 cannabinoid receptor (CB2R) leads to decreased type 2 inflammation and reduced production of arachidonic acid (AA). Given that altered AA metabolism is associated with aspirin-exacerbated respiratory disease (AERD), we hypothesized that expression of the CB2R gene CNR2 is increased in AERD. METHODS: Nasal polyps from consecutive patients undergoing endoscopic sinus surgery for AERD or allergic fungal rhinosinusitis (AFRS) were prospectively evaluated...
June 13, 2018: International Forum of Allergy & Rhinology
Yalcin Alimoglu, Adem Topcu
OBJECTIVE: The aim of this study was to investigate the distances between the anterior nasal spine and basal lamella (BL), skull base, nasofrontal beak (NfB), and the anterior wall of sphenoid sinus on computed tomography (CT) images. METHODS: A total of 160 patients who were seen at the otolaryngology clinic of our institution were evaluated with the help of the image processing software of the radiology department. Cases in which bony structures could not be seen clearly because of previous surgery or trauma were excluded...
June 11, 2018: Journal of Craniofacial Surgery
Juan M Revuelta Barbero, Alaa S Montaser, Mostafa Shahein, André Beer-Furlan, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
The endoscopic endonasal approach (EEA) provides direct access to foramen magnum meningiomas; however, it often requires extensive exposure including septal flap elevation with septum removal, complete sphenoidotomy, and panclivectomy.We present a case of a 54-yr-old-female with an incidental foramen magnum lesion followed up with serial imaging who presented 10 mo later with progressive neck discomfort and episodes of dizziness, with confirmed tumor progression and further brainstem compression. A focal transclival EEA with medial condylectomy was performed preserving the upper two-thirds of the clivus, the nasal septum, and the sphenoid sinus...
June 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
Mehrdad Gholami, Daryoush Shahbazi-Gahrouei
Background: The human body consists of a variety of tissues and cavities with different physical and radiological properties. The most important among these are tissues and cavities including lungs, oral cavities, teeth, nasal passages, sinuses, and bones. Thus, the dose distribution in these tissues cannot be verified with soft tissue equivalent polymer gel dosimeters. This study is conducted to evaluate the effect of homogeneity on dose response of an anoxic low-density polymer gel dosimeter for radiation therapy...
April 2018: Journal of Cancer Research and Therapeutics
Akbar Aliasgharzadeh, Ehsan Mihandoost, Mehran Mohseni
Background: Nowadays, the use of computed tomography (CT) as a diagnostic tool has been considerably increased. Therefore, implementation of the program to conform the protection regulations on the CT scan is necessary to reduce the detrimental effects of radiation. Objective: This study was performed to measure weighted CT dose index (CTDIW ) and dose length product (DLP) in routine CT protocols of the adult patients. Methods: In this study, the patient dose was determined in routine CT protocols...
April 2018: Journal of Cancer Research and Therapeutics
E Eviatar, Y Golan, H Gavriel
OBJECTIVE: To describe a newly observed frontal sinus anatomical variant, the fronto-septal rostrum. METHODS: Consecutive sinus computed tomography scans performed during 2013 were reviewed. The fronto-septal rostrum was defined as a mucosa-lined air space formed in the attachment of the most upper bony nasal septum and the central floor of the frontal sinuses. RESULTS: The study included 400 computed tomography scans from 189 women (47.3 per cent) and 211 men (52...
May 2018: Journal of Laryngology and Otology
Tanya M Laidlaw, Katherine N Cahill, Juan Carlos Cardet, Katherine Murphy, Jing Cui, Brittney Dioneda, Parul Kothari, Benjamin A Raby, Elliot Israel, Joshua Boyce
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, recurrent nasal polyposis, and respiratory reactions upon ingestion of cyclooxygenase-1 inhibitors. Increased numbers of platelet-leukocyte aggregates are present in the sinus tissue and blood of patients with AERD, compared to aspirin-tolerant patients, and platelet activation may contribute to aspirin-induced reactions. OBJECTIVE: We sought to determine whether treatment with prasugrel, which inhibits platelet activation by blocking the P2Y12 receptor, would attenuate the severity of sinonasal and respiratory symptoms induced during aspirin challenge in subjects with AERD...
June 8, 2018: Journal of Allergy and Clinical Immunology
R Jankowski, C Rumeau, D T Nguyen, P Gallet
Nasalisation is a surgical technique proposed for the treatment of nasal polyposis in 1995. The technique as initially described was based on large opening of the maxillary, sphenoidal and frontal ostia and resection of the middle turbinates, with the aim of resecting the mucosa of the lateral masses of the ethmoid as completely and safely as possible. Recent findings on the evolution and development of the nose and sinuses and sinus physiology allow both the concept and the technique of nasalisation to be updated...
June 7, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Christopher R Roxbury, Dennis Tang, Janki Shah, Jennifer McBride, Troy D Woodard, Raj Sindwani
BACKGROUND: The endoscopic modified Lothrop procedure (EMLP) is commonly performed in recalcitrant frontal sinusitis, in part to achieve better penetration of medicated irrigations postoperatively. Although EMLP requires a septectomy for exposure, it is unknown whether septectomy size affects delivery of irrigations. In this study we evaluated the role of septectomy in delivery of irrigations to the EMLP cavity. METHODS: EMLP was performed on fresh human cadavers with sequentially increasing septectomy (minimal septectomy: drilling across septum to combine frontal sinuses; standard septectomy: 1...
June 8, 2018: International Forum of Allergy & Rhinology
Matti Penttilä
BACKGROUND: The ostiomeatal complex (OMC), comprising a small natural maxillary sinus ostium and narrow infundibulum, transmits the air diffusion into the antrum and mucociliary transport from the antrum, and is considered a key area in chronic rhinosinusitis (CRS). Thin membranous anterior and posterior fontanelle areas below the OMC can rupture forming a perforation, accessory maxillary ostium (AMO), that increases antral airflow changing the anatomy and function of the sinus. The purpose of this study was to report the first case series of CRS patients who had undergone repair of fontanelle defects aiming to reconstruct normal structures...
June 8, 2018: International Forum of Allergy & Rhinology
Sarah Tait, Dorina Kallogjeri, Jasmina Suko, Sara Kukuljan, John Schneider, Jay F Piccirillo
Importance: Recent studies suggest that budesonide added to saline nasal lavage can be an effective treatment for patients with chronic rhinosinusitis (CRS). Objective: To evaluate the incremental effect of adding budesonide to large-volume, low-pressure saline sinus irrigation. Design, Setting, and Participants: This double-blind, placebo-controlled, randomized clinical trial was conducted at a quaternary care academic medical center between January 1, 2016, and February 16, 2017...
June 7, 2018: JAMA Otolaryngology—Head & Neck Surgery
Yuki Omori, Erick Ricardo Silva, Daniele Botticelli, Karol Alí Apaza Alccayhuaman, Niklaus P Lang, Samuel P Xavier
OBJECTIVE: To test if repositioning the bony plate secured with a cyanoacrylate over the antrostomy in maxillary sinus augmentation was superior to covering the antrostomy with a collagen membrane in terms of the bone augmentation area and the bone density. MATERIAL AND METHODS: After the exposure of the nasal bone in eighteen rabbits, a rectangular access window was prepared with a sonic instrument, and the bony plate was removed. A bilateral sinus mucosa elevation was performed, and the space was filled with a resorbable xenograft...
June 7, 2018: Clinical Oral Implants Research
Ebrahim Karimi, Akbar Bayat, Mohammad Reza Ghahari, Sara Rahavi-Ezabadi, Mehrdad Jafari
Introduction: The major presenting symptom of nasal polyps is nasal obstruction. The role of nasal obstruction in the genesis of laryngeal disorders is still unknown. Materials and Methods: The aim of this study was to evaluate laryngeal videostroboscopic changes after functional endoscopic sinus surgery (FESS) in patients with nasal polyposis. A longitudinal study was carried out from March 2012 to June 2013. Thirty patients with bilateral nasal polyposis who did not respond to maximum medical treatment and were candidates for FESS were recruited...
May 2018: Iranian Journal of Otorhinolaryngology
D Wu, C S Wang, L Zhang
Sinonasal inverted papilloma is the most common seen benign disease of nasal cavities and paranasal sinuses area characterized by great recurrence rate and malignancy tendency. The infection of human papillomavirus is considered as a risk factor playing a role underneath the mechanism. However, the association between the infection of HPV and the recurrence or malignancy of SNIP remains controversial. By summarizing the existing research results, this paper further explores the association between HPV infection and SNIP...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Y J Chen, X B Chai
Chronic rhinosinusitis with or without nasal polyps mainly uses combination of medications represented by nasal glucocorticoids and functional sinus endoscopic surgery (FESS) and comprehensive treatment with antibiotics. The effect of oral antibiotics for CRS exacerbations on the microbial resistance rate in the population has not yet been fully assessed, but may be significant, and glucocorticoid-resistant CRS has also emerged. CRSwNP associated with complications of asthma is considered a more serious condition...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
J Y Li, F Chen, C J Yu, X F Ma, H Li, H D Wang
Objective: To investigate the efficacy of radical sinus surgery (RSS) on difficult-to-treat rhinosinusitis(DTRS) with nasal polyps. Method: We retrospectively analyzed the clinical data of 26 patients with DTRS that treated with RSS and patients who were not treated with RSS in our hospital from August 2013 to June 2017.The effect of RSS were evaluated by comparing the CT Lund-Kennery score,endoscope Lund-Kennery score,global VAS score and dysosmia VAS score before operation and 6 months after operation. Result: RSS group had more severe Lund-Kennery score,global VAS score and dysosmia VAS score than non-RSS group,and also had more previous surgeries,higher ratio of olfactory region polyps,and higher ratio of co-existing asthma and allergic rhinitis...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Olivia Francies, Levan Makalanda, Dimitris Paraskevopolous, Ashok Adams
The anterior skull base (ASB) is intimately associated with the unique soft tissue subtypes of the nasal cavity, paranasal sinuses, orbits, and intracranial compartment. Pathology involving the ASB is rare but the causes are manifold and can be broadly subdivided into those intrinsic to the skull base and processes extending from below or above. Sinonasal pathology is the most commonly encountered and poses significant management challenges that rely heavily on accurate interpretation of the radiological findings...
May 2018: Acta Radiologica Open
Haitham H Hassane, Mirza M Beg, Chokkalingam Siva, Celso Velázquez
BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Her physical examination showed nasal congestion and purpuric rash on the lower extremities...
June 6, 2018: American Journal of Case Reports
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