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Nasal polyps

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https://www.readbyqxmd.com/read/28102059/v%C3%AE-1%C3%A2-%C2%BA-%C3%AE-%C3%AE-t-cells-are-correlated-with-increasing-expression-of-eosinophil-cationic-protein-and-metalloproteinase-7-in-chronic-rhinosinusitis-with-nasal-polyps-inducing-the-formation-of-edema
#1
Luo Ying Yang, Xia Li, Wen Ting Li, Jian Cong Huang, Zhi Yuan Wang, Zi Zhen Huang, Li Hong Chang, Ge Hua Zhang
PURPOSE: We have found that expression of γδT cells is increased in pathological mucosa of chronic rhinosinusitis with nasal polyps (CRSwNP) compared with normal nasal mucosa. This increase is correlated with the infiltration of eosinophils in CRSwNP. Here, we investigated the expression of γδT cells, inflammation and tissue remodeling factors as well as their probable relationships in different types of chronic rhinosinusitis (CRS) in China. METHODS: A total of 76 surgical tissue samples that included 43 CRSwNP samples (15 eosinophilic and 28 non-eosinophilic), 17 CRS samples without nasal polyps (CRSsNP), and 16 controls were obtained...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28099884/characterization-of-human-and-staphylococcus-aureus-proteins-in-respiratory-mucosa-by-in-vivo-and-immunoproteomics
#2
Frank Schmidt, Tanja Meyer, Nandakumar Sundaramoorthy, Stephan Michalik, Kristin Surmann, Maren Depke, Vishnu Dhople, Manuela Gesell Salazar, Gabriele Holtappels, Nan Zhang, Barbara M Bröker, Claus Bachert, Uwe Völker
: Staphylococcus aureus is a Gram-positive opportunistic bacterium which can be found as a commensal in the nares of about 50% of the human population. Besides asymptomatic carriage, S. aureus has also been found to colonize nasal polyps, a subform of chronic rhinosinusitis, in 60 to 100% of cases, and even reside intracellularly in nasal polyp tissue. The aim of this study was to shed light on the behavior of S. aureus in the human airways by analyzing S. aureus-specific proteins in nasal polyp tissue from patients with chronic rhinosinusitis and to characterize the immunogenic potential of the identified (mainly secreted) proteins...
January 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28071713/sinonasal-delivery-of-resveratrol-via-mucoadhesive-nanostructured-microparticles-in-a-nasal-polyp-mouse-model
#3
Mingyu Lee, Chun Gwon Park, Beom Kang Huh, Se-Na Kim, Seung Ho Lee, Roza Khalmuratova, Jong-Wan Park, Hyun-Woo Shin, Young Bin Choy
Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained manner...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28059551/wnt-signaling-in-chronic-rhinosinusitis-with-nasal-polyps
#4
Robert Böscke, Eszter K Vladar, Michael Könnecke, Birgit Hüsing, Robert Linke, Ralph Pries, Norbert Reiling, Jeffrey D Axelrod, Jayakar V Nayak, Barbara Wollenberg
The signaling pathways that sustain the disease process of chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly understood. We sought to determine the expression levels of Wnt signaling genes in CRSwNP, and to study the role of the Wnt pathway in inflammation and epithelial remodeling in the nasal mucosa. Microarrays and RT-qPCR comparing gene expression in matched nasal polyps (NP) and inferior turbinates (IT) revealed that WNT2B, WNT3A, WNT4, WNT7A, WNT7B and FZD2 were upregulated, and FZD1, LRP5, LRP6 and WIF1 downregulated in NPs...
January 6, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28051265/the-role-of-hypoxia-inducible-factor-in-nasal-inflammations
#5
K-J Cheng, Y-Y Bao, S-H Zhou
OBJECTIVE: Hypoxia-inducible factor (HIF) is considered an important transcription factor due to its roles in glycolysis, angiogenesis, cell differentiation, apoptosis, and other cellular pathways. It takes the role in various physiological and pathological states, such as solid tumors, vascular injury, and atherosclerotic lesion progression. In recent studies, HIF is found as a master regulator of body inflammation and immunity, not only in hypoxia but also in normoxia. Nasal inflammation has a close relationship with anoxia...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28050473/evaluation-of-sinonasal-diseases-by-computed-tomography
#6
Rashmi Kandukuri, Suresh Phatak
INTRODUCTION: Computed Tomography (CT) plays an important diagnostic role in patients with sinonasal diseases and determines the treatment. The CT images clearly show fine structural architecture of bony anatomy thereby determining various anatomical variation, extent of disease and characterization of various inflammatory, benign and malignant sinonasal diseases. AIM: To evaluate sensitivity and specificity of CT in diagnosis of sinonasal diseases and to characterise the benign and malignant lesions with the help of various CT parameters...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042687/unsupervised-network-mapping-of-commercially-available-immunoassay-yields-three-distinct-chronic-rhinosinusitis-endotypes
#7
Rohit Divekar, Matthew Rank, Diane Squillace, Hirohito Kita, Devyani Lal
BACKGROUND: Endotyping chronic rhinosinusitis (CRS) through simplified cytokine assays may help direct individualized therapy such as corticosteroids, antibiotics, or biologics. We performed an unsupervised network analysis to endotype CRS and control subjects using a commercially available cytokine-chemokine immunoassay. METHODS: A 41-plex cytokine-chemokine array along with major basic protein (MBP) assay was performed on sinonasal surgical tissue of 32 adults...
January 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28035475/increased-baff-expression-in-nasal-polyps-is-associated-with-local-ige-production-th2-response-and-concomitant-asthma
#8
Dilidaer, Yan Zheng, Zhuofu Liu, Xianting Hu, Jia Zhang, Li Hu, Miaomiao Han, Dehui Wang, Huabin Li
B-cell activating factor of the TNF family is critical for the survival and maturation of B cells and play a role in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). In this study, nasal tissues were enrolled from 25 CRSwNP patients (asthmatic, 16; non-asthmatic, 9), 12 CRSsNP patients and ten control subjects, respectively. The immunoreactivity of BAFF, CD20 and CD138 were examined using immunohistochemistry staining. The mRNA expression of BAFF, CD20, εGLT, AID, GATA3 and CRTH2 were examined using real-time RT-PCR...
December 29, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28026837/trigeminal-sensitivity-in-chronic-rhinosinusitis-topographical-di-erences-and-the-e-ect-of-surgery
#9
S C Poletti, M Cuevas, S Weile, T Hummel
INTRODUCTION: Little is known on endonasal trigeminal sensitivity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of our study was to investigate changes in trigeminal sensitivity in patients with CRSwNP and the effect of functional endoscopic sinus surgery (FESS) on trigeminal perception. METHODS: A prospective study was performed to investigate the trigeminal sensitivity at three different locations within the nose (anterior septum, anterior lateral wall, middle turbinate) using electrical stimuli...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28018456/esthesioneuroblastoma-in-a-boy-with-47-xyy-karyotype
#10
Hee Cheol Jo, Seong Wook Lee, Hyun Joo Jung, Jun Eun Park
Neuroblastomas are sometimes associated with abnormal constitutional karyotypes, but the XYY karyotype has been rarely described in neuroblastomas. Here, we report a case of an esthesioneuroblastoma in a boy with a 47, XYY karyotype. A 6-year-old boy was admitted to our hospital because of nasal obstruction and palpable cervical lymph node, which he first noticed several days previously. A polypoid mass in the right nasal cavity was detected through sinuscopy. Biopsy of the right nasal polyp was performed. Based on the result, the patient was diagnosed with a high-grade esthesioneuroblastoma...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28017629/identifying-risk-of-future-asthma-attacks-using-uk-medical-record-data-a-respiratory-effectiveness-group-initiative
#11
John D Blakey, David B Price, Emilio Pizzichini, Todor A Popov, Borislav D Dimitrov, Dirkje S Postma, Lynn K Josephs, Alan Kaplan, Alberto Papi, Marjan Kerkhof, Elizabeth V Hillyer, Alison Chisholm, Mike Thomas
BACKGROUND: Asthma attacks are common, serious, and costly. Individual factors associated with attacks, such as poor symptom control, are not robust predictors. OBJECTIVE: We investigated whether the rich data available in UK electronic medical records could identify patients at risk of recurrent attacks. METHODS: We analyzed anonymized, longitudinal medical records of 118,981 patients with actively treated asthma (ages 12-80 years) and 3 or more years of data...
December 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28000955/chronic-airway-inflammation-provides-a-unique-environment-for-b-cell-activation-and-antibody-production
#12
Scott Feldman, Richard Kasjanski, Julie Popowski, David Hernandez, Jason Chen, James E Norton, Lydia Suh, Roderick G Carter, Whitney W Stevens, Anju T Peters, Robert C Kern, David B Conley, Bruce K Tan, Stephani Shintani-Smith, Kevin C Welch, Leslie C Grammer, Kathleen E Harris, Atsushi Kato, Robert P Schleimer, Kathryn E Hulse
BACKGROUND: B cells play many roles in health and disease. However, little is known about the mechanisms that drive B cell responses in the airways, especially in humans. Chronic rhinosinusitis (CRS) is an inflammatory disease of the upper airways that affects 10% of Europeans and Americans. A subset of CRS patients develop nasal polyps (NP), which are characterized by type 2 inflammation, eosinophils and group 2 innate lymphoid cells (ILC2). We have reported that NP contain elevated levels of B cells and antibodies, making NP an ideal system for studying B cells in the airways...
December 21, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27994648/sinonasal-glomangiopericytoma-treated-with-preoperative-embolisation-and-endoscopic-sinus-surgery
#13
Elizabeth Psoma, Petros D Karkos, Stamatia Dova, Michail Gavriilidis, Konstantinos Markou, Constantinos Kouskouras, Afroditi Haritanti, Stefanos Finitsis
Sinonasal glomangiopericytoma is a benign rare tumour of pericytes that accounts for less than 0.5% of all sinonasal tumours. It is an indolent tumour with a macroscopic appearance of common inflammatory polyps. We report the case of a 55-year-old male who presented with right nasal obstruction. CT and MRI examinations demonstrated a soft-tissue mass that obstructed mainly the right nasal cavity. Biopsy revealed glomangiopericytoma. The tumour was treated with preoperative embolisation followed by complete endoscopic resection...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27993536/neutrophils-are-a-major-source-of-the-epithelial-barrier-disrupting-cytokine-oncostatin-m-in-patients-with-mucosal-airways-disease
#14
Kathryn L Pothoven, James E Norton, Lydia A Suh, Roderick G Carter, Kathleen E Harris, Assel Biyasheva, Kevin Welch, Stephanie Shintani-Smith, David B Conley, Mark C Liu, Atsushi Kato, Pedro C Avila, Qutayba Hamid, Leslie C Grammer, Anju T Peters, Robert C Kern, Bruce K Tan, Robert P Schleimer
BACKGROUND: We have previously shown that oncostatin M (OSM) levels are increased in nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic patients. We also showed in vitro that physiologic levels of OSM impair barrier function in differentiated airway epithelium. OBJECTIVE: We sought to determine which hematopoietic or resident cell type or types were the source of the OSM expressed in patients with mucosal airways disease...
December 18, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27992119/the-prognostic-role-of-serum-eosinophil-and-basophil-levels-in-sinonasal-polyposis
#15
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Luciano Giacomelli, Alessandro Martini, Gino Marioni
BACKGROUND: Predicting which patients are at a higher risk for recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. A direct association between CRSwNP recurrence rates and serum eosinophil and basophil counts was reported. This study aimed to identify best-fitting cutoffs for binarizing preoperative serum eosinophils and basophils (counts/percentages) for prognostic purposes in cases of CRSwNP recurrence after surgery...
December 19, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27979430/classical-complement-pathway-activation-in-the-nasal-tissue-of-patients-with-chronic-rhinosinusitis
#16
Griet A Van Roey, Christopher C Vanison, Jeffanie Wu, Julia H Huang, Lydia A Suh, Roderick G Carter, James E Norton, Stephanie Shintani-Smith, David B Conley, Kevin C Welch, Anju T Peters, Leslie C Grammer, Kathleen E Harris, Kathryn E Hulse, Atsushi Kato, Whitney W Stevens, Robert C Kern, Robert P Schleimer, Bruce K Tan
BACKGROUND: Complement plays a major role in inflammatory diseases but its involvement and mechanisms of activation in chronic rhinosinusitis (CRS) are not known. OBJECTIVES: Following earlier studies discovering autoantibodies in CRS, we sought to investigate the nature, extent, and location of complement activation in nasal tissue of patients with CRS. Specifically, we were interested in whether antibody-mediated activation via the classical pathway was a major mechanism for complement activation in CRS...
December 12, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27978888/-treatment-for-intraorbital-hematoma-by-orbital-decompression-after-surgery-of-recurrent-nasal-polyps-a-case-report
#17
W J Shi, Y N Zhang, P Lin, X Peng
No abstract text is available yet for this article.
December 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27978883/-investigation-on-the-expression-of-microvessel-pericyte-coverage-index-and-lymph-vessel-density-in-nasal-polyps
#18
N Cui, D D Zhu, G M Guan, J C Sha, C D Meng, L Li, Q Xiu
Objective: To investigate the role of lymph vessel density (LVD) and microvessel pericyte coverage index (MPI) in the pathogenesis of nasal polyps. Methods: Using immunohistochemistry and immunofluorescence double staining method, the expressions of albumin, D2-40 and CD34-α-SMA in 11 specimens of normal nasal mucosa, 26 specimens of nasal polyp and 26 specimens of inferior turbinate tissue from patients with nasal polyps were investigated. The counts of microvessel density (MVD), lymph vessel density (LVD) and microvessel pericyte coverage index (MPI) were compared...
December 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27978879/-subjective-and-objective-evaluation-and-correlation-analysis-of-pre-and-post-operation-in-patients-with-structural-nasal-obstruction
#19
X P Yuan, Q R Guo, C L Geng, Y Liu, M Wang, Z M Xing
Objective: To analyze the subjective and objective results and the correlation of nasal obstruction because of nasal structural variation pre and post operation, and to provide clinical evidence for surgery and curative effect. Methods: Three groups were included in this study: group 1 were 78 patients with structural rhinitis, group 2 were 72 patients with chronic sinusitis (without nasal polyp) and group 3 were healthy controls of 75 cases. Assessment of nasal obstruction was achieved by visual analog scale (VAS), and objective measurement was achieved by rhinomanometry and acoustic rhinometry...
December 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27959637/immunopathogenesis-of-chronic-rhinosinusitis-and-nasal-polyposis
#20
Robert P Schleimer
Chronic rhinosinusitis (CRS) is a troublesome, chronic inflammatory disease that affects over 10% of the adult population, causing decreased quality of life, lost productivity, and lost time at work and leading to more than a million surgical interventions annually worldwide. The nose, paranasal sinuses, and associated lymphoid tissues play important roles in homeostasis and immunity, and CRS significantly impairs these normal functions. Pathogenic mechanisms of CRS have recently become the focus of intense investigations worldwide, and significant progress has been made...
December 5, 2016: Annual Review of Pathology
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