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Chronic rhinosinusitis

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https://www.readbyqxmd.com/read/29223553/lipopolysaccharide-induces-autophagy-by-targeting-the-ampk-mtor-pathway-in-human-nasal-epithelial-cells
#1
Xue-Hai Wang, Zhong-Hua Zhang, Xiao-Lan Cai, Ping Ye, Xin Feng, Ting-Ting Liu, Xue-Zhong Li
Chronic rhinosinusitis (CRS) is a well-known disease encountered in the department of otorhinolaryngology, yet little is known about its pathogenesis. Autophagy, a lysosome-dependent degradation process, has been reported to be involved in the process of many chronic inflammatory diseases. Here we tried to evaluate the function of autophagy in CRS as well as explore the related mechanisms. We first stained light chain 3B (LC3B) with immunohistochemistry in uncinate tissues (UT) from patients with and without CRS and found that its expression was up-regulated in CRS patients...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29214756/serum-cytokine-profile-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis-infected-by-aspergillus-flavus
#2
Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Das
BACKGROUND: Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of T helper (Th) cell subset Th1, Th2, and Th17 cytokines and total IgE in patients having chronic rhinosinusitis with nasal polyposis and Aspergillus flavus infection. METHODS: A case-control study including 40 patients with chronic rhinosinusitis with nasal polyposis and 20 healthy controls was conducted...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29210519/air-pollutants-may-be-environmental-risk-factors-in-chronic-rhinosinusitis-disease-progression
#3
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas J Willson, Stella E Lee
BACKGROUND: Little is known about the role of environmental exposures in the pathophysiology of chronic rhinosinusitis (CRS). In this study, we measured the impact of air pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). METHODS: Spatial modeling from pollutant monitoring sites was used to estimate exposures surrounding residences for patients meeting inclusion criteria (total patients, n = 234; CRSsNP, n = 96; CRSwNP, n = 138)...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29210504/endoscopic-modified-lothrop-procedure-after-failure-of-primary-endoscopic-sinus-surgery-a-meta-analysis
#4
Waleed M Abuzeid, Mayand Vakil, Juan Lin, Judd Fastenberg, Nadeem A Akbar, Marvin P Fried, Christina H Fang
BACKGROUND: The endoscopic modified Lothrop procedure (EMLP) has been used as a salvage technique for frontal sinusitis following failed endoscopic sinus surgery (ESS). We aim to examine the safety and efficacy of the EMLP following failure of primary ESS. METHODS: All English-language publications from 2000 to 2016 reporting the use of EMLP after primary ESS were identified using the PubMed database and evaluated per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29209499/nasal-muco-ciliary-transport-time-alteration-efficacy-of-18-b-glycyrrhetinic-acid
#5
Desiderio Passali, Chiara Cappello, Giulio Cesare Passali, Cemal Cingi, Codrut Sarafoleanu, Luisa Maria Bellussi
Background: Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses.This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29204922/usefulness-of-our-proposed-olfactory-scoring-system-during-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis
#6
Ken Okazaki, Kenzo Tsuzuki, Kengo Hashimoto, Hiroki Nishikawa, Hironori Takebayashi, Hideki Oka, Yusuke Kojima, Yoriko Yukitatsu, Yasuo Mishiro, Masafumi Sakagami
INTRODUCTION: The primary aim of the current study was to examine the usefulness of our proposed olfactory scoring system in chronic rhinosinusitis (CRS) patients with olfactory disorders (n = 213) receiving endoscopic sinus surgery (ESS). MATERIALS AND METHODS: Analyzed patients were divided into two groups: an eosinophilic CRS (ECRS) group (n = 153); and a non-ECRS group (n = 60). The T&T recognition threshold test was used to evaluate olfaction at baseline and at 3 and 12 months after ESS...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29202870/clinical-predictors-of-chronic-rhinosinusitis-do-the-canadian-clinical-practice-guidelines-for-acute-and-chronic-rhinosinusitis-predict-ct-confirmation-of-disease
#7
Paige Moore, Brian Blakley, Eric Meen
BACKGROUND: The diagnosis of chronic rhinosinusitis (CRS) based on clinical presentation alone remains challenging. To improve the accuracy of clinical diagnosis, the Canadian Rhinosinusitis Guidelines recommend the use of specific symptom and endoscopic criteria. Our study objective was to determine whether symptom and endoscopic criteria, as defined by the Canadian Rhinosinusitis Guidelines, accurately predict CT-confirmed CRS diagnosis. METHODS: A retrospective cohort study of 126 patients who underwent CT sinuses based on clinical suspicion of possible CRS...
December 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29202566/post-operative-nebulized-sodium-hyaluronate-versus-spray-after-functional-endoscopic-sinus-surgery-for-chronic-rhinosinusitis
#8
M Casale, A Pace, A Moffa, P Vella, L Sabatino, M A Lopez, F Salvinelli
We prospectively evaluated the efficacy of nebulized Hyaluronic Acid (HA) as an adjuvant treatment to hasten the improvement of nasal respiration and to minimize patients’ discomfort in the postoperative functional endoscopic sinus surgery (FESS) for chronic rhino-sinusitis (CRS). We enrolled 33 CRS adult patients who underwent endoscopic functional sinus surgery. They were randomly assigned into two groups: Spray-Sol group (18 patients) with HA nebulized with a new nasal device named Spray-Sol and Spray group (15 patients) with a HA nebulized with a common spray...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202565/the-efficacy-of-topical-hyaluronan-in-rhinosinusitis-a-systematic-review
#9
M Casale, P Vella, A Moffa, V Grimaldi, L Sabatino, V Rinaldi, M A Lopez, P Baptista, F Salvinelli
Rhinosinusitis is one of the most common inflammatory conditions of the nasal cavity and paranasal sinuses and is one of the most common causes of absence from work and for visits to the family doctor. The treatment strategy in both acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) is to reduce the severity of the symptoms, minimize the duration of the disease and prevent complications. Topical therapy has become an important tool in otolaryngologists’ armamentarium for rhinosinusitis treatment. Recently, topical hyaluronic acid (HA), the major component of many extracellular matrices that promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration and angiogenesis, has been proposed for ARS and CRS adjuvant tool...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29197105/upper-and-lower-airway-remodelling-mechanisms-in-asthma-allergic-rhinitis-and-chronic-rhinosinusitis-the-one-airway-concept-revisited
#10
REVIEW
Konstantinos Samitas, Alison Carter, Harsha H Kariyawasam, Georgina Xanthou
Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co-exist. The one airway model proposes that disease mechanisms occurring in the upper airway may mirror lower airway events. Airway remodelling is the term used to describe tissue structural changes that occur in a disease setting and reflect the dynamic process of tissue restructuring during wound repair. Remodelling has been long identified in the lower airways in asthma and is characterized by epithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, airway smooth muscle hyperplasia and increased angiogenesis...
December 1, 2017: Allergy
https://www.readbyqxmd.com/read/29195025/lack-of-additional-effects-of-long-term-low-dose-clarithromycin-combined-treatment-compared-with-topical-steroids-alone-for-chronic-rhinosinusitis-in-china-a-randomized-controlled-trial
#11
Jie Deng, Fenghong Chen, YinYan Lai, Qing Luo, Rui Xu, Chunquan Ou, Qingling Fu, Jianbo Shi
BACKGROUND: In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was to determine whether a topical steroid and clarithromycin combination is better than a single topical steroid for Chinese patients with CRS. METHODS: Patients with CRS with/without nasal polyps were included in this study and randomly assigned to a clarithromycin plus budesonide aqua nasal spray group (CLM + BUD, clarithromycin 0...
November 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193850/olfactory-loss-in-chronic-rhinosinusitis-is-associated-with-neuronal-activation-of-c-jun-n-terminal-kinase
#12
Andrew J Victores, Mengfei Chen, Amy Smith, Andrew P Lane
BACKGROUND: Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in programmed cell death in neuroinflammation, its specific role in CRS-associated olfactory loss has not been thoroughly investigated. METHODS: JNK activation was studied in human tissue samples from 9 control and 11 CRS patients by immunohistochemical staining for phosphorylated c-Jun...
November 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193105/correlations-between-cystic-fibrosis-genotype-and-sinus-disease-severity-in-chronic-rhinosinusitis
#13
Waleed M Abuzeid, Changeun Song, Judd H Fastenberg, Christina H Fang, Noel Ayoub, Elina Jerschow, Paul K Mohabir, Peter H Hwang
OBJECTIVE: Cystic fibrosis (CF) patients commonly develop chronic rhinosinusitis (CRS). The impact of the most common cystic fibrosis transmembrane conductance regulator (CFTR) mutation, F508del, on the severity of sinonasal disease remains inconclusive. The objective of this study is to evaluate the impact of CFTR genotype functional classification on sinonasal disease severity in patients with CRS. METHODS: Retrospective chart review of patients with CF who underwent endoscopic sinus surgery for chronic rhinosinusitis from 1998 to 2015...
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29186722/il-33-expression-in-chronic-rhinosinusitis-with-nasal-polyps-and-its-relationship-with-clinical-severity
#14
Wei Song, Chunlei Wang, Jing Zhou, Shenghua Pan, Sen Lin
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by epithelial inflammation and tissue eosinophilic infiltration. Interleukin-33 (IL-33) is a key inflammatory cytokine that mediates eosinophilic infiltration. OBJECTIVE: The aim of our study was to investigate the expression and role of IL-33 in eosinophilic CRS with nasal polyps (ECRSwNP) and in noneosinophilic CRS with nasal polyps (nECRSwNP), and to analyze their correlation with clinical severity...
November 30, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29183867/the-epidermal-growth-factor-receptor-inhibitor-ag1478-inhibits-eosinophilic-inflammation-in-upper-airways
#15
Shino Shimizu, Kumiko Takezawa-Yasuoka, Takao Ogawa, Ichiro Tojima, Hideaki Kouzaki, Takeshi Shimizu
Mucus hypersecretion and eosinophil infiltration are important characteristics of eosinophilic inflammation in upper airways, such as allergic rhinitis and chronic rhinosinusitis with nasal polyp. EGFR transactivation induces mucus and inflammatory cytokine secretion from airway epithelial cells. However, the roles of EGFR in eosinophilic inflammation in upper airways are still unknown. The purpose of the study is to elucidate the effects of the EGFR inhibitor AG1478 on eosinophilic airway inflammation. AG1478 significantly inhibited thrombin-induced GM-CSF secretion from nasal epithelial cells and thrombin-induced secretion of eotaxin-1 and RANTES from nasal fibroblasts...
November 25, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29183012/differential-expression-of-the-aryl-hydrocarbon-receptor-and-transforming-growth-factor-beta-1-in-chronic-rhinosinusitis-with-nasal-polyps-with-allergic-rhinitis
#16
Lu Chen, Ling Xiao, Jie Liu, Yang Shen, Xia Ke, Jiangju Huang, Guohua Hu, Yucheng Yang
OBJECTIVE: This study aimed to determine the aryl hydrocarbon receptor (AhR) and transforming growth factor beta 1 (TGF-β1) expression levels in chronic rhinosinusitis (CRS) and their possible correlation with allergic state and tissue remodeling. METHODS: Patients were enrolled and divided into the following groups: CRS without nasal polyps (NP) without allergic rhinitis (AR) (CRSsNPsAR; n = 20), CRS with NP with AR (CRSwNPwAR; n = 20), CRS with NP without AR (CRSwNPsAR; n = 20), and controls (n = 15)...
November 29, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29178954/the-effectiveness-of-topical-colloidal-silver-in-recalcitrant-chronic-rhinosinusitis-a-randomized-crossover-control-trial
#17
John R Scott, Rohin Krishnan, Brian W Rotenberg, Leigh J Sowerby
BACKGROUND: Recalcitrant chronic rhinosinusitis without polyposis (CRSsP) is a challenging condition to manage as traditional medical therapies and surgery fail to provide satisfactory clinical improvements. Colloidal silver (CS), a widely used naturopathic agent, has recently shown anti-biofilm properties both in vitro and within a rhinosinusitis animal model. To date, no trials involving humans have been published in world literature. The purpose of this study was to assess the efficacy of CS as a topical nasal spray in patients with refractory CRSsP...
November 25, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29178130/comorbid-treatable-traits-in-difficult-asthma-current-evidence-and-clinical-evaluation
#18
REVIEW
Tunn Ren Tay, Mark Hew
The care of patients with difficult-to-control asthma ('difficult asthma') is challenging and costly. Despite high-intensity asthma treatment, these patients experience poor asthma control and face the greatest risk for asthma morbidity and mortality. Poor asthma control is often driven by severe asthma biology, which has appropriately been the focus of intense research and phenotype-driven therapies. However, it is increasing apparent that extra-pulmonary comorbidities also contribute substantially to poor asthma control and a heightened disease burden...
November 27, 2017: Allergy
https://www.readbyqxmd.com/read/29177948/increased-serum-amyloid-a-in-nasal-polyps-is-associated-with-systemic-corticosteroid-insensitivity-in-patients-with-chronic-rhinosinusitis-with-nasal-polyps-a-pilot-study
#19
Hangui Lu, Xin-Sheng Lin, Dan-Mian Yao, Ying-Ying Zhuang, Guo-Feng Wen, Jianbo Shi, Yue-Qi Sun
BACKGROUND: Serum amyloid A (SAA) was involved in the pathogenesis of glucocorticoid resistance in lung diseases. However, their association with systemic corticosteroid insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP) patients remains to be assessed. METHODS: This study enrolled 32 CRSwNP patients to evaluate the association between SAA expression in NP and corticosteroid insensitivity, and the value of polyp SAA level for predicting the response to oral corticosteroids in CRSwNP patients...
November 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29176480/how-does-sinus-surgery-affect-topical-irrigation-distribution
#20
Sandro H de Paiva Leite, Richard G Douglas
PURPOSE OF REVIEW: The current article reviews the literature on the distribution of nasal irrigation in the treatment of chronic sinusitis, especially in how sinus surgery and irrigation techniques affect its delivery to the nasal cavity and paranasal sinuses. RECENT FINDINGS: Nasal irrigation has become a useful tool in the treatment of chronic sinusitis. Used after endoscopic surgery of the paranasal sinuses, irrigation has shown to be effective in improving edema and removing crusts and secretions in that place...
November 14, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
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