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Chronic rhinosinusitis

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https://www.readbyqxmd.com/read/29466477/mysinusitiscoach-patient-empowerment-in-chronic-rhinosinusitis-using-mobile-technology
#1
S F Seys, J Bousquet, C Bachert, W J Fokkens, I Agache, M Bernal-Sprekelsen, I Callebaut, L O Cardel, S Carrie, P Castelnuovo, R Cathcart, J Constantinidis, L Cools, M Cornet, G Clement, J C de Sousa, T Cox, M Doulaptsi, P Gevaert, C Hopkins, V Hox, T Hummel, W Hosemann, R Jacobs, M Jorissen, B N Landis, A Leunig, V J Lund, J Mullol, M Onerci, S Palkonen, I Proano, E Prokopakis, D Ryan, H Riechelmann, J Saevels, C Segboer, K Speleman, E A Steinsvik, P Surda, P V Tomasiz, O Vanderveken, L Van Gerven, T Van Zele, B Verhaeghe, K Vierstraete, S Vlaminck, J Wilkinson, S Williams, B Pugin, P W Hellings
Mobile health technology is emerging to take a prominent position in the management of chronic diseases. These technologies aim at enhancing patient empowerment via education and self-management. To date, of all the different apps available for patients with sinus disease, none were developed by medical experts dealing with chronic rhinosinusitis (CRS). The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) has undertaken a multi-stakeholder approach for designing, developing and implementing a tool to support CRS patients in monitoring their symptoms and to provide patients with a digital support platform containing reliable medical information about their disease and treatment options...
February 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29465510/chronic-rhinosinusitis-related-to-occupational-exposure-the-telemark-population-study
#2
Ulrika K E Clarhed, Martin Svendsen, Linus Schiöler, Johny Kongerud, Kjell Torén, Johan Hellgren, Anne Kristin Fell
OBJECTIVE: To investigate the association between occupational exposure and chronic rhinosinusitis. METHODS: A random population from the region of Telemark, aged 16-50, answered a respiratory questionnaire including questions on chronic rhinosinusitis and exposure in the occupational environment. RESULTS: A total of 16,099/48,142 subjects responded. The prevalence of chronic rhinosinusitis was 9%. Exposure associated with chronic rhinosinusitis comprised paper dust (OR 1...
February 19, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29460678/a-systematic-review-of-the-association-between-cigarette-smoke-exposure-and-chronic-rhinosinusitis
#3
Dallin N Christensen, Zechariah G Franks, Hilary C McCrary, Ahlam A Saleh, And Eugene H Chang
Objectives Cigarette smoking and passive smoke exposure have been associated with chronic rhinosinusitis (CRS). Our goal in this systematic review was to (1) determine if there was a strong correlative effect in large population studies between cigarette smoke exposure and the prevalence of CRS, (2) investigate pathogenic mechanisms of cigarette smoke in the upper airway, and (3) determine if a history of cigarette smoking affects the medical and surgical outcomes of CRS. Data Sources MEDLINE, Embase, Cochrane CENTRAL, Web of Science SCI and CPCI-S, and websites...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29456949/clarithromycin-in-the-management-of-chronic-rhinosinusitis-preliminary-results-of-a-possible-its-new-use
#4
F Sireci, R Speciale, S Gallina, R Sorrentino, F R Canevari
The aim of this study is to evaluate the efficacy and safety of prolonged therapy with low-dose clarithromycin in patients with chronic rhinosinusitis with polyps (CRSwP) after endoscopic sinus surgery (ESS). A total of 10 patients with CRSwP were identified and subjected to bilateral ESS. In post-operative patients they were treated with nasal wash with saline solution and steroid sprays (beclomethasone). During follow-up, after 30-40 days after the operation (M = 35.4 SD = +4.33), patients reported a worsening of symptoms with onset of nasal obstruction; reduction/loss of smell; headache; onset of viscous secretions and therefore all patients continued therapy with saline nasal irrigation, topical steroid therapy and started macrolide (clarithromycin 500 mg/pill: 1 pill/day for 3 days a week for 1 month)...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456942/bacterial-biofilms-in-chronic-rhinosinusitis-and-their-implications-for-clinical-management
#5
Abhilasha Karunasagar, Santosh S Garag, Suma B Appannavar, Raghavendra D Kulkarni, Ashok S Naik
To study the microbiological profile in patients with chronic rhino-sinusitis. To correlate disease severity with the presence of biofilms and host risk factors. To assess outcome of Sinus Surgery 2 weeks post operatively in terms of presence of bacteria and their ability to form biofilm. Prospective study. 50 cases of chronic rhino-sinusitis requiring Functional Endoscopic Sinus Surgery admitted in SDM Hospital, Dharwad, Karnataka were studied using intra-operative mucosal samples for microbiological analysis...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456658/expression-of-clara-cell-10-kda-protein-and-trefoil-factor-family-1-in-patients-with-chronic-rhinosinusitis-and-nasal-polyps
#6
Yuanyuan Wang, Zong-Feng Wang, Zhili Zhang, Yi Su
The current study measured the expression of Clara cell 10-kDa protein (CC10) and trefoil factor family 1 (TFF1) in the sinus mucosa of patients exhibiting chronic rhinosinusitis (CRS) and nasal polyps (NP). CC10 and TFF1 expression in the sinus mucosa of the control group and patients with CRS and NP was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blotting and immunohistochemistry. The correlation between CC10 and TFF1 expression was further analyzed using Spearman's correlation analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29452201/the-nasal-microbiome-in-chronic-rhinosinusitis-analyzing-the-effects-of-atopy-and-bacterial-functional-pathways-in-111-patients
#7
Mahboobeh Mahdavinia, Phillip A Engen, Phillip S LoSavio, Ankur Naqib, Rafsa J Khan, Mary C Tobin, Arpita Mehta, Raj Kota, Nailliw Preite, Christopher D Codispoti, Bobby A Tajudeen, Robert P Schleimer, Stefan J Green, Ali Keshavarzian, Pete S Batra
No abstract text is available yet for this article.
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29452200/identification-of-clinically-relevant-chronic-rhinosinusitis-endotypes-using-cluster-analysis-of-mucus-cytokines
#8
Justin H Turner, Rakesh K Chandra, Ping Li, Kemberlee Bonnet, David G Schlundt
No abstract text is available yet for this article.
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29450780/systematic-reviews-and-meta-analysis-in-rhinosinusitis-a-critical-review-of-the-reviews
#9
REVIEW
Abigail Walker, Claire Hopkins
PURPOSE OF REVIEW: There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS: While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerning reader. Attention therefore must be given to review methodology before implanting findings. Organisations such as the Cochrane Collaboration promote high-quality reviews, but are limited in chronic sinus disease by heterogeneous outcomes and a paucity of randomised trials...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29450659/social-factors-in-the-development-of-chronic-rhinosinusitis-a-systematic-review
#10
REVIEW
I Geramas, D Terzakis, E Hatzimanolis, C Georgalas
PURPOSE OF REVIEW: In an era where prevention is paramount, understanding social factors for chronic rhinosinusitis (CRS) may facilitate preventive interventions that mitigate risk factors associated with the initiation or progression of the disease. RECENT FINDINGS: Both passive and active smoking are clearly and unequivocally associated with both the incidence and the severity of rhinosinusitis, while there an increasing body of evidence linking social deprivation and low socioeconomic status with rhinosinusitis and its complications...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29449345/antimicrobial-activity-of-a-novel-bioengineered-honey-against-non-typeable-haemophilus-influenzae-biofilms-an-in-vitro-study
#11
Rachel S Newby, Matthew Dryden, Raymond N Allan, Rami J Salib
The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi colonisation, persistence of infection and recalcitrance towards antimicrobials. There is therefore a pressing need for the development of novel treatment strategies that are effective against NTHi biofilm-associated diseases. SurgihoneyRO is a honey-based product that has been bioengineered to enable the slow release of H 2 O 2 , a reactive oxygen species to which H...
February 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29447888/pathogenesis-of-chronic-rhinosinusitis-in-patients-affected-by-%C3%AE-thalassemia-major-and-sickle-cell-anaemia-post-allogenic-bone-marrow-transplant
#12
F Martino, R Di Mauro, K Paciaroni, J Gaziev, C Alfieri, L Greco, R Floris, S Di Girolamo, M Di Girolamo
OBJECTIVES: Sickle cell anemia (SCA) and β -thalassemia major are well-recognized beta-globin gene disorders of red blood cells associated to mortality and morbidity included bone morbidities due to ineffective erythropoiesis and bone marrow expansion, which affect every part of the skeleton. While there are an abundance of described disease manifestations of the head and neck, the manner of paranasal sinuses involvement and its relations to β-thalassemia and SCA process was not studied yet...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29437297/snot-22-based-clusters-in-chronic-rhinosinusitis-without-nasal-polyposis-exhibit-distinct-endotypic-and-prognostic-differences
#13
Devyani Lal, Claire Hopkins, Rohit D Divekar
BACKGROUND: Endotypic and prognosticating features of chronic rhinosinusitis without nasal polyposis (CRSsNP) are poorly understood. Our objectives were to use an unbiased symptom-based approach to: (1) study symptoms, clinical and endotypic features; and (2) identify features predicating outcomes from endoscopic sinus surgery (ESS). METHODS: Clinical, computed tomography (CT), histopathology, and 22-item Sino-Nasal Outcome Test (SNOT-22) data was collected on 146 adult CRSsNP patients who underwent ESS...
February 13, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29432969/age-related-prevalence-of-chronic-rhinosinusitis-and-nasal-polyps-and-their-relationships-with-asthma-onset
#14
Ha-Kyeong Won, Young-Chan Kim, Min-Gyu Kang, Han-Ki Park, Seung-Eun Lee, Min-Hye Kim, Min-Suk Yang, Yoon-Seok Chang, Sang-Heon Cho, Woo-Jung Song
BACKGROUND: Chronic rhinosinusitis (CRS) is a major disease condition with high morbidity, and may influence lower airway disease status in adults. However, its associations with adult asthma onset and activity have not been examined in detail in a general adult population. OBJECTIVE: To investigate the relationships between CRS with nasal polyps and asthma characteristics. METHODS: A cross-sectional dataset from 17,506 adult participants (age≥18 years) in the Korean National Health and Nutrition Examination Survey 2010-2012 was analyzed...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#15
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis. METHODS: A cross-sectional prospective study was carried out in adult patients with persistent asthma-like symptoms and negative bronchodilator testing...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29431874/short-chain-fatty-acids-induce-tissue-plasminogen-activator-in-airway-epithelial-cells-via-gpr41-43
#16
Yoshimasa Imoto, Atsushi Kato, Tetsuji Takabayashi, Masafumi Sakashita, James E Norton, Lydia A Suh, Roderick G Carter, Ava R Weibman, Kathryn E Hulse, Whitney Stevens, Kathleen E Harris, Anju T Peters, Leslie C Grammer, Bruce K Tan, Kevin Welch, David B Conley, Robert C Kern, Shigeharu Fujieda, Robert P Schleimer
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease generally divided based on presence or absence of nasal polyps (NPs). One of the features of NPs is excessive fibrin deposition, which is associated with down regulation of tissue plasminogen activator (t-PA) in NPs. As t-PA is expressed in epithelial cells, and epithelium is readily accessible to topical therapies, identifying compounds that can mediate the induction of t-PA would be a potential new strategy for the treatment of NPs...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29429191/-mechanisms-underlying-glucocorticoid-resistance-in-chronic-rhinosinusitis-with-nasal-polyps
#17
Y Y Zhang, H F Lou, C S Wang, L Zhang
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease that occurs in the nasal and sinus mucosa, which is a common disease in otorhinolaryngology. At present, CRSwNP can be effectively treated by glucocorticoids (GC). GC binds to GC receptors in the nasal mucosa, affects the expression of inflammatory genes, inhibits the activation and action of eosinophils, T cell-associated inflammatory responses in nasal polyps, as well as tissue remodeling. However, there are some patients fall reponse to GC, so called GC resistance...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29426723/topical-therapy-for-refractory-rhinosinusitis-caused-by-methicillin-resistant-staphylococcus-aureus-first-report-in-a-prospective-series
#18
Alan H Shikani, Nadim Khoueir, Mary Ann Jabra-Rizk, Henry J Shikani, Randall J Basaraba, Jeff G Leid
OBJECTIVE: The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients. METHODS: Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses...
February 6, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29424885/use-of-balloon-catheter-dilation-vs-traditional-endoscopic-sinus-surgery-in-management-of-light-and-severe-chronic-rhinosinusitis-of-the-frontal-sinus-a-multicenter-prospective-randomized-study
#19
A Minni, A Dragonetti, A Sciuto, C Cavaliere, D Rosati, D Azimonti, A Franzetti
OBJECTIVE: Chronic rhinosinusitis (CRS) of the frontal sinus is a complex pathological condition and many surgical techniques were described to treat this area endoscopically, like traditional endoscopic sinus surgery (ESS) and balloon catheter dilation (BCD). PATIENTS AND METHODS: We designed a multicenter prospective randomized study to assess the validity and safety of BCD vs. ESS in symptomatological chronic rhinosinusitis of the frontal sinus enrolling a population of 102 adult patients (64 men and 38 women; overall 148 frontal sinuses studied) with non-polypoid CRS...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#20
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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