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https://www.readbyqxmd.com/read/28741331/alignment-of-adherence-and-risk-for-hiv-acquisition-in-a-demonstration-project-of-pre-exposure-prophylaxis-among-hiv-serodiscordant-couples-in-kenya-and-uganda-a-prospective-analysis-of-prevention-effective-adherence
#1
Jessica E Haberer, Lara Kidoguchi, Renee Heffron, Nelly Mugo, Elizabeth Bukusi, Elly Katabira, Stephen Asiimwe, Katherine K Thomas, Connie Celum, Jared M Baeten
INTRODUCTION: Adherence is essential for pre-exposure prophylaxis (PrEP) to protect against HIV acquisition, but PrEP use need not be life-long. PrEP is most efficient when its use is aligned with periods of risk - a concept termed prevention-effective adherence. The objective of this paper is to describe prevention-effective adherence and predictors of adherence within an open-label delivery project of integrated PrEP and antiretroviral therapy (ART) among HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project)...
July 25, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28737591/hiv-incidence-and-predictors-of-hiv-acquisition-from-an-outside-partner-in-serodiscordant-couples-in-lusaka-zambia-1995-2012
#2
Dvora L Joseph Davey, Kristin M Wall, William Kilembe, Htee Khu Naw, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakt, Pamina Gorbach, Susan Allen
OBJECTIVE: Evaluate the incidence and predictors of HIV acquisition from outside partners in serodiscordant couples. METHODS: Demographic, behavioral, and clinical exposures were measured quarterly in a cohort of serodiscordant cohabiting couples in Zambia from 1995-2012 (n=3049). Genetic analysis classified incident infections as those acquired from the study partner (linked) or acquired from an outside partner (unlinked). Factors associated with time to unlinked HIV infection were evaluated using multivariable Cox proportional hazards regression stratified by gender...
July 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28732773/efficacy-of-oral-pre-exposure-prophylaxis-prep-for-hiv-among-women-with-abnormal-vaginal-microbiota-a-post-hoc-analysis-of-the-randomised-placebo-controlled-partners-prep-study
#3
Renee Heffron, R Scott McClelland, Jennifer E Balkus, Connie Celum, Craig R Cohen, Nelly Mugo, Elizabeth Bukusi, Deborah Donnell, Jairam Lingappa, James Kiarie, Tina Fiedler, Matthew Munch, David N Fredricks, Jared M Baeten
BACKGROUND: Daily oral tenofovir-based pre-exposure prophylaxis (PrEP) is high efficacious for HIV prevention among women with high adherence. However, the effect of abnormal vaginal microbiota on PrEP efficacy is of concern. We investigated whether bacterial vaginosis modified the efficacy of oral PrEP. METHODS: We used prospectively collected data from women in the Partners PrEP Study, a placebo-controlled trial of daily oral PrEP (either tenofovir monotherapy or a combination of tenofovir and emtricitabine) in HIV serodiscordant couples aged 18 years or older in Kenya and Uganda that showed high efficacy in women...
July 18, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28719229/experiences-using-pre-exposure-prophylaxis-for-safer-conception-among-hiv-serodiscordant-heterosexual-couples-in-the-united-states
#4
Angela R Bazzi, Ashley A Leech, Dea L Biancarelli, Meg Sullivan, Mari-Lynn Drainoni
Antiretroviral pre-exposure prophylaxis (PrEP) is a promising HIV prevention strategy for HIV serodiscordant couples (HIV-infected male, uninfected female) seeking safer conception. However, most research on PrEP for safer conception has focused on couples in sub-Saharan Africa; little is known about the perspectives or experiences of heterosexual couples in the United States. We conducted qualitative interviews with six couples (six women and five of their male partners) receiving PrEP for conception services at an urban safety net hospital in the US Northeast...
July 18, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28637581/how-partnership-type-and-hiv-seroconcordance-affect-hiv-transmission-risk-in-regular-sexual-partnerships-a-cross-sectional-survey-of-australian-gay-and-bisexual-men
#5
Benjamin R Bavinton, Andrew E Grulich, Duane Duncan, Iryna B Zablotska, Garrett P Prestage
Background: Regular sexual partnerships among gay and bisexual men (GBM) who practice condomless anal intercourse (CLAI) have not been well characterised in terms of partnership type, HIV seroconcordance and risk of HIV transmission. Primarily sexual regular partnerships, although commonly reported by gay men, have largely been ignored in research and HIV prevention. Among regular partners reporting CLAI with each other, we determined factors differentiating romantic or committed relationships from partnerships organised primarily around sex ('fuckbuddies') and estimated the proportion of CLAI presenting risk for HIV transmission...
June 22, 2017: Sexual Health
https://www.readbyqxmd.com/read/28634661/depression-and-art-initiation-among-hiv-serodiscordant-couples-in-kenya-and-uganda
#6
Jennifer Velloza, Connie Celum, Jessica E Haberer, Kenneth Ngure, Elizabeth Irungu, Nelly Mugo, Jared M Baeten, Renee Heffron
Depression is a known barrier for antiretroviral therapy (ART) adherence, but less is understood about its effects on ART initiation. We followed 1013 HIV-infected individuals participating in the Partners Demonstration Project, an open-label study of integrated pre-exposure prophylaxis (PrEP) and ART delivery for HIV serodiscordant couples in Kenya and Uganda. Associations between depression, measured annually with the Hopkins Symptoms Checklist-Depression (HSCL-D), and ART initiation were assessed with Cox proportional hazards regression...
June 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28591373/-vulnerability-to-hiv-infection-in-serodiscordant-couples-in-rio-de-janeiro-brazil
#7
Nilo Martinez Fernandes, Élida Azevedo Hennington, Jefferson de Souza Bernardes, Beatriz G Grinsztejn
A new era in HIV/AIDS treatment began in 1996 with the advent of highly active antiretroviral therapy (HAART). The advent of these new medicines expanded the treatment resources and improved life expectancy and quality of life for persons living with HIV and AIDS, favoring the maintenance and initiation of relationships between partners with discordant HIV serological status. The main objective of this study with serodiscordant couples was to understand the three dimensions of vulnerability - programmatic, social, and individual - in these couples...
June 1, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28567279/evolving-treatment-implementation-among-hiv-infected-pregnant-women-and-their-partners-results-from-a-national-surveillance-study-in-italy-2001-2015
#8
Marco Floridia, Valentina Frisina, Marina Ravizza, Anna Maria Marconi, Carmela Pinnetti, Irene Cetin, Matilde Sansone, Atim Molinari, Francesca Cervi, Alessandra Meloni, Kety Luzi, Giulia Masuelli, Enrica Tamburrini
BACKGROUND: The current global and national indications for antiretroviral treatment (ART, usually triple combination therapy) in adolescent and adults, including pregnant women, recommend early ART before immunologic decline, pre-exposure chemoprophylaxis (PrEP), and treatment of HIV-negative partners in serodiscordant couples. There is limited information on the implementation of these recommendations among pregnant women with HIV and their partners. METHODS: The present analysis was performed in 2016, using data from clinical records of pregnant women with HIV, followed between 2001 and 2015 at hospital or university clinics within a large, nationally representative Italian cohort study...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28562661/effects-of-patient-load-and-travel-distance-on-hiv-transmission-in-rural-china-implications-for-treatment-as-prevention
#9
M Kumi Smith, William C Miller, Huixin Liu, Chuanyi Ning, Wensheng He, Myron S Cohen, Ning Wang
BACKGROUND: Sustained viral suppression through ART reduces sexual HIV transmission risk, but may require routine access to reliable and effective medical care which may be difficult to obtain in resource constrained areas. We investigated the roles of patient load and travel distance to HIV care clinic on transmission risk in HIV serodiscordant couples in Henan Province, China. METHODS: Cox proportional hazard models were used to compare HIV transmission events across couples living near, medium, or farther distances from their assigned HIV care clinics, as well as those attending clinics where clinicians bore high versus low patient loads...
2017: PloS One
https://www.readbyqxmd.com/read/28549302/partner-level-substance-use-associated-with-increased-sexual-risk-behaviors-among-men-who-have-sex-with-men-in-san-francisco-ca
#10
Robert E Brown, Caitlin Turner, Jaclyn Hern, Glenn-Milo Santos
BACKGROUND: Substance use is highly prevalent among men who have sex with men (MSM) and is associated with individual-level sexual risk behaviors. However, few studies have explored the relationship between substance use and HIV risk behaviors within partnerships. METHODS: We examined partner-level data between MSM participants (n=23) and their sexual partners (n=52). We used multivariable generalized estimating equations (GEE) logistic regression to assess the relationship between partner-level substance use during their last sexual encounter with each partner, and engaging in condomless anal intercourse (CAI) and serodiscordant CAI...
April 21, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28441179/kidney-transplant-outcomes-in-hiv-serodiscordant-recipient-pairs
#11
Esther N Gathogo, Sapna Shah, Frank A Post
No abstract text is available yet for this article.
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28402405/sexual-networks-dyadic-characteristics-and-hiv-acquisition-and-transmission-behaviors-among-black-men-who-have-sex-with-men-in-6-us-cities
#12
DeMarc A Hickson, Leandro A Mena, Leo Wilton, Hong-Van Tieu, Beryl A Koblin, Vanessa Cummings, Carl Latkin, Kenneth H Mayer
The role of sexual networks in the epidemiology of human immunodeficiency virus (HIV) among black men who have sex with men (MSM) is poorly understood. Using data from 1,306 black MSM in the BROTHERS Study (2009-2010) in the United States, we examined the relationships between multiple sexual dyadic characteristics and serodiscordant/serostatus-unknown condomless sex (SDCS). HIV-infected participants had higher odds of SDCS when having sex at least weekly (odds ratio (OR) = 2.41, 95% confidence interval (CI): 1...
May 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28398593/ccr5-expression-haplotype-and-immune-activation-in-protection-from-infection-in-hiv-exposed-uninfected-individuals-in-hiv-serodiscordant-relationships
#13
Shameem Z Jaumdally, Anabela Picton, Caroline T Tiemessen, Maria Paximadis, Heather B Jaspan, Hoyam Gamieldien, Lindi Masson, David Coetzee, Anna-Lise Williamson, Francesca Little, Pamela P Gumbi, Jo-Ann S Passmore
Several host factors have been implicated in resistance to HIV infection in individuals who remain HIV-seronegative despite exposure. In a cohort of HIV-serodiscordant heterosexual couples, we investigated interactions between systemic inflammation and T-cell activation in resistance to HIV infection. Males and females in stable long-term relationships with either HIV-infected or uninfected partners were recruited, blood T-cell activation (CD38, HLA-DR, CCR5 and Ki67) and plasma cytokine concentrations were evaluated...
August 2017: Immunology
https://www.readbyqxmd.com/read/28385131/virologic-outcomes-in-early-antiretroviral-treatment-hptn-052
#14
Susan H Eshleman, Ethan A Wilson, Xinyi C Zhang, San-San Ou, Estelle Piwowar-Manning, Joseph J Eron, Marybeth McCauley, Theresa Gamble, Joel E Gallant, Mina C Hosseinipour, Nagalingeswaran Kumarasamy, James G Hakim, Ben Kalonga, Jose H Pilotto, Beatriz Grinsztejn, Sheela V Godbole, Nuntisa Chotirosniramit, Breno Riegel Santos, Emily Shava, Lisa A Mills, Ravindre Panchia, Noluthando Mwelase, Kenneth H Mayer, Ying Q Chen, Myron S Cohen, Jessica M Fogel
INTRODUCTION: The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early antiretroviral therapy (ART) prevented 93% of HIV transmission events in serodiscordant couples. Some linked infections were observed shortly after ART initiation or after virologic failure. OBJECTIVE: To evaluate factors associated with time to viral suppression and virologic failure in participants who initiated ART in HPTN 052. METHODS: 1566 participants who had a viral load (VL) > 400 copies/mL at enrollment were included in the analyses...
April 7, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28377421/a-cross-sectional-analysis-of-trichomonas-vaginalis-infection-among-heterosexual-hiv-1-serodiscordant-african-couples
#15
Aaron F Bochner, Jared M Baeten, Alison S Rustagi, Edith Nakku-Joloba, Jairam R Lingappa, Nelly R Mugo, Elizabeth A Bukusi, Saidi Kapiga, Sinead Delany-Moretlwe, Connie Celum, Ruanne V Barnabas
OBJECTIVES: Trichomonas vaginalis is the most prevalent curable STI worldwide and has been associated with adverse health outcomes and increased HIV-1 transmission risk. We conducted a cross-sectional analysis among couples to assess how characteristics of both individuals in sexual partnerships are associated with the prevalence of male and female T. vaginalis infection. METHODS: African HIV-1 serodiscordant heterosexual couples were concurrently tested for trichomoniasis at enrolment into two clinical trials...
April 4, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28373665/polyfunctional-natural-killer-cells-with-a-low-activation-profile-in-response-to-toll-like-receptor-3-activation-in-hiv-1-exposed-seronegative-subjects
#16
Josenilson F Lima, Luanda M S Oliveira, Nátalli Z Pereira, Alberto J S Duarte, Maria N Sato
Natural killer (NK) cells are the main mediator of the cytotoxic response in innate immunity and may be involved in resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Toll-like receptor (TLR) signalling is crucial for NK cell activation. Here, we investigated the polyfunctional NK cell response to TLR3 activation in serodiscordant couples. ESN subjects showed increased IFN-γ and CD107a expression in both NK subsets, CD56(bright) and CD56(dim) cells, in response to stimulation with a TLR3 agonist, while expression was impaired in the HIV-1-infected partners...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362073/feasibility-and-acceptability-of-hiv-self-testing-among-pre-exposure-prophylaxis-users-in-kenya
#17
Kenneth Ngure, Renee Heffron, Nelly Mugo, Kerry A Thomson, Elizabeth Irungu, Njambi Njuguna, Lawrence Mwaniki, Connie Celum, Jared M Baeten
INTRODUCTION: HIV testing is key to the delivery of pre-exposure prophylaxis (PrEP): testing HIV-uninfected at-risk persons is the first step for PrEP initiation and ongoing HIV testing is an essential part of PrEP delivery. Thus, novel and cost-effective HIV-testing approaches to streamline delivery of PrEP are urgently needed. Within a demonstration project of PrEP for HIV prevention among high-risk HIV serodiscordant couples in Kenya (the Partners Demonstration Project), we conducted a pilot evaluation of HIV self-testing...
February 8, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28362069/supporting-people-living-with-hiv-in-serodiscordant-partnerships-to-attempt-a-desired-pregnancy-by-integrating-sexual-and-reproductive-health-and-hiv-interventions
#18
EDITORIAL
Manjulaa Narasimhan, Connie Celum, Ian Askew, James Kiarie, Sheryl van der Poel
No abstract text is available yet for this article.
February 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28361508/delivering-safer-conception-services-to-hiv-serodiscordant-couples-in-kenya-perspectives-from-healthcare-providers-and-hiv-serodiscordant-couples
#19
Kenneth Ngure, Grace Kimemia, Kristin Dew, Njambi Njuguna, Nelly Mugo, Connie Celum, Jared M Baeten, Renee Heffron
INTRODUCTION: For HIV serodiscordant couples in resource-limited settings, pregnancy is common despite the risk of sexual and/or perinatal HIV transmission. Some safer conception strategies to reduce HIV transmission during pregnancy attempts are available but often not used for reasons including knowledge, accessibility, preference and others. We sought to understand Kenyan health providers' and HIV serodiscordant couples' perspectives and experiences with safer conception. METHODS: Between August 2015 and March 2016, we conducted key informant interviews (KIIs) with health providers from public and private HIV care and fertility clinics and in-depth interviews (IDIs) and focus group discussions (FGDs) with HIV serodiscordant couples participating in an open-label study of integrated pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV prevention (the Partners Demonstration Project)...
March 8, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28361507/client-uptake-of-safer-conception-strategies-implementation-outcomes-from-the-sakh-umndeni-safer-conception-clinic-in-south-africa
#20
Sheree R Schwartz, Jean Bassett, Charles B Holmes, Nompumelelo Yende, Rebecca Phofa, Ian Sanne, Annelies Van Rie
INTRODUCTION: Implementation of safer conception services for HIV-affected couples within primary healthcare clinics in resource-limited settings remains limited. We review service utilization and safer conception strategy uptake during the first three years of Sakh'umndeni, which is a safer conception clinic in South Africa. METHODS: Sakh'umndeni is located at Witkoppen Health and Welfare Centre, a high-volume primary healthcare clinic in northern Johannesburg...
March 8, 2017: Journal of the International AIDS Society
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