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https://www.readbyqxmd.com/read/29334545/bacterial-vaginosis-modifies-the-association-between-hormonal-contraception-and-hiv-acquisition
#1
Lisa Haddad, Kristin M Wall, William Kilembe, Bellington Vwailika, Naw Htee, Ilene Brill, Elwyn Chomba, Amanda Tichacek, Susan Allen
OBJECTIVE: To examine BV as an effect modifier for the association between hormonal contraception (HC) and incident HIV infection DESIGN:: Serodiscordant couples enrolled in an open longitudinal cohort in Lusaka, Zambia from 1994-2012. This analysis was restricted to couples with an HIV-positive man enrolled between1994-2002 when a quarterly genital tract examination and HIV testing was performed. METHODS: Multivariate Cox models evaluated the association between contraceptive method and HIV-acquisition, stratified by time-varying BV status...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334178/factors-associated-with-perceived-accuracy-of-the-undetectable%C3%A2-%C3%A2-untransmittable-slogan-among-men-who-have-sex-with-men-implications-for-messaging-scale-up-and-implementation
#2
H Jonathon Rendina, Jeffrey T Parsons
INTRODUCTION: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29329426/a-practical-guide-to-estimating-the-heritability-of-pathogen-traits
#3
Venelin Mitov, Tanja Stadler
Pathogen traits, such as the virulence of an infection, can vary significantly between patients. A major challenge is to measure the extent to which genetic differences between infecting strains explain the observed variation of the trait. This is quantified by the trait's broad-sense heritability, H2. A recent discrepancy between estimates of the heritability of HIV-virulence has opened a debate on the estimators' accuracy. Here, we show that the discrepancy originates from model limitations and important lifecycle differences between sexually reproducing organisms and transmittable pathogens...
January 9, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29258341/sexual-risk-taking-and-the-hiv-care-continuum-in-an-online-sample-of-men-who-have-sex-with-men
#4
Irene S Yoon, Martin J Downing, Richard Teran, Mary Ann Chiasson, Steven T Houang, Jeffrey T Parsons, Sabina Hirshfield
Antiretroviral Therapy (ART) suppresses HIV replication, reducing the risk of transmission. However, many people living with HIV in the US are not virally suppressed even after diagnosis and initiating ART, and may become disengaged from care at each stage of the HIV care continuum (HCC). In the current study we assessed the sexual risk behaviors of MSM by HCC stage. US MSM who completed an online survey (N = 12,995) in 2015 were categorized into 6 HCC groups. Mean age was 39.2 and a majority identified as White (49...
December 19, 2017: AIDS Care
https://www.readbyqxmd.com/read/29238237/adolescent-pre-exposure-prophylaxis-for-hiv-prevention-current-perspectives
#5
REVIEW
Daisy Maria Machado, Alexandre Machado de Sant'Anna Carvalho, Rachel Riera
Adolescents are a critical population that is disproportionately impacted by the HIV epidemic. More than 2 million adolescents between the age group of 10 and 19 years are living with HIV, and millions are at risk of infection. HIV risks are considerably higher among girls, especially in high-prevalence settings such as eastern and southern Africa. In addition to girls, there are other vulnerable adolescent subgroups, such as teenagers, who use intravenous (IV) drugs, gay and bisexual boys, transgender youth, male sex workers, and people who fall into more than one of these categories...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29230242/families-living-with-blood-borne-viruses-the-case-for-extending-the-concept-of-serodiscordance
#6
REVIEW
Asha Persson, Christy E Newman, Myra Hamilton, Joanne Bryant, Jack Wallace, Kylie Valentine
The concept of "serodiscordance" (mixed infection status) is primarily associated with epidemiological concerns about HIV transmission risk in couples. We make the case for extending this concept to include families with mixed HIV and viral hepatitis status. Social research on couples with mixed HIV and hepatitis C status has laid an important foundation for illuminating how experiences of serodiscordance within intimate partnerships are much broader than concerns about risk. This body of work attests to serodiscordance holding promise as a valuable concept for understanding viral infections as socially situated and intensely relational phenomena...
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#7
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29174161/a-role-for-fc-mediated-humoral-immunity-in-reducing-hiv-transmission-rates-between-hiv-serodiscordant-heterosexual-couples
#8
Stephen J Kent, Amy W Chung
No abstract text is available yet for this article.
November 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29160480/possibilities-of-care-for-serodiscordant-couples-for-hiv-who-got-pregnant
#9
Tassiane Ferreira Langendorf, Ivis Emília de Oliveira Souza, Stela Maris de Mello Padoin, Cristiane Cardoso de Paula, Ana Beatriz Azevedo Queiroz, Maria Aparecida Vasconcelos Moura, Maria Carmen Simões Cardoso de Melo, Lúcia de Fatima da Silva
OBJECTIVE: Understanding the meaning of pregnancy for heterosexual couples facing serodiscordant situation for HIV, aiming at construction of care possibilities based on subjectivity. METHOD: Phenomenological research, theoretical-philosophical-methodological framework by Martin Heidegger. Research was conducted in a University Hospital in the countryside of Southern Brazil, from September 2013 to May 2014 through a phenomenological interview, with participation of eleven couples...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29129698/evaluation-of-different-parameters-of-humoral-and-cellular-immune-responses-in-hiv-serodiscordant-heterosexual-couples-humoral-response-potentially-implicated-in-modulating-transmission-rates
#10
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental. In this context, cohorts of HIV serodiscordant heterosexual couples (SDC) represent a unique tool. The present study was aimed to evaluate specific parameters of innate, cellular and humoral immune responses in SDC. Specifically, plasma levels of cytokines and chemokines, HIV-specific T-cell responses, gp120-specific IgG and IgA antibodies, and HIV-specific antibody-dependent cellular cytotoxicity (ADCC) activity were assessed in nine HIV-exposed seronegative individuals (ESN) and their corresponding HIV seropositive partners (HIV+-P), in eighteen chronically infected HIV subjects (C), nine chronically infected subjects known to be HIV transmitters (CT) and ten healthy HIV- donors (HD)...
December 2017: EBioMedicine
https://www.readbyqxmd.com/read/29077673/condomless-sex-among-virally-suppressed-women-with-hiv-with-regular-hiv-serodiscordant-sexual-partners-in-the-era-of-treatment-as-prevention
#11
Sophie Patterson, Allison Carter, Valerie Nicholson, Kath Webster, Erin Ding, Mary Kestler, Gina Ogilvie, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
BACKGROUND: Sexual HIV transmission does not occur with sustained undetectable viral load (VL) on antiretroviral therapy (ART). Awareness of ART prevention benefits and its influence on condom use among women with HIV (WWH) remain unexplored. We estimated prevalence and correlates of condomless sex with regular HIV-serodiscordant partners among WWH with undetectable VL on ART. METHODS: We used baseline questionnaire data from the community-based longitudinal Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29076883/intimate-partner-violence-and-self-reported-pre-exposure-prophylaxis-prep-interruptions-among-hiv-negative-partners-in-hiv-serodiscordant-couples-in-kenya-and-uganda
#12
Alejandra Cabral, Jared Baeten, Kenneth Ngure, Jennifer Velloza, Josephine Odoyo, Jessica Haberer, Connie Celum, Timothy Muwonge, Stephen Asiimwe, Renee Heffron
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention and PrEP delivery studies are investigating ways to deliver PrEP with high adherence. However, in many settings with high HIV burden, intimate partner violence (IPV) is reported often and could be a barrier to effective PrEP use. We examined the association between IPV and interruptions in PrEP use. METHODS: We analyzed data from 1,013 serodiscordant heterosexual couples enrolled in a large PrEP demonstration project in Kenya and Uganda, the Partners Demonstration Project...
October 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29076033/patterns-of-online-and-offline-connectedness-among-gay-bisexual-and-other-men-who-have-sex-with-men
#13
Kiffer G Card, Heather L Armstrong, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Eric A Roth, Robert S Hogg
This study examined patterns of connectedness among 774 sexually-active gay, bisexual, and other men who have sex with men (GBM), aged ≥ 16 years, recruited using respondent-driven sampling in Metro Vancouver. Latent class analysis examined patterns of connectedness including: attendance at gay venues/events (i.e., bars/clubs, community groups, pride parades), social time spent with GBM, use of online social and sex seeking apps/websites, and consumption of gay media. Multinomial regression identified correlates of class membership...
October 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29073829/hiv-testing-among-male-partners-of-pregnant-women-in-nigeria-a-missing-link-in-the-elimination-of-mother-to-child-transmission-of-hiv
#14
Babayemi O Olakunde, Daniel A Adeyinka, Tolulope Oladele, Chamberline E Ozigbu
In this study, we assessed male partner testing and the serodiscordance rate among pregnant women and their partners in the prevention of mother-to-child transmission (PMTCT) programme in Nigeria. We conducted a retrospective analysis of the consolidated national health sector PMTCT data over a five-year period (2012-2016). Over the period, a total of 11,833,062 pregnant women were tested for HIV with a positivity rate of 2.2%. About 266,188 (2.2%) of sexual partners of pregnant women who presented at PMTCT clinics had an HIV test within the period...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29040666/maternal-tenofovir-disoproxil-fumarate-use-during-pregnancy-is-not-associated-with-adverse-perinatal-outcomes-among-hiv-infected-east-african-women-a-prospective-study
#15
Jillian Pintye, Jared M Baeten, Connie Celum, Nelly Mugo, Kenneth Ngure, Edwin Were, Elizabeth Bukusi, Grace John-Stewart, Renee A Heffron
Background: Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and pre-exposure prophylaxis regimens. We evaluated the relationship between adverse perinatal outcomes and prenatal TDF use. Methods: Longitudinal data were analyzed from HIV-infected women who became pregnant during two HIV prevention studies conducted among HIV-serodiscordant couples in Kenya and Uganda. Pregnancies were included if singleton, not terminated by an induced abortion and had documentation of 3-drug ART use...
October 10, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29026872/top-questions-in-id-pre-exposure-prophylaxis-for-hiv
#16
Douglas S Krakower, Stephanie E Cohen, Kenneth H Mayer
HIV pre-exposure prophylaxis (PrEP) is highly efficacious at preventing HIV acquisition. This review discusses ways to identify candidates for PrEP, recommended PrEP regimens, baseline and follow-up evaluations, applications of PrEP for HIV-serodiscordant couples, resources to address financial barriers, investigational strategies for PrEP, and educational resources for clinicians and patients.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29016523/prep-use-during-periods-of-hiv-risk-among-east-african-women-in-serodiscordant-relationships
#17
Maria Pyra, Jessica E Haberer, Renee Heffron, Lara Kidoguchi, Elizabeth R Brown, Elizabeth A Bukusi, Stephen Asiimwe, Connie Celum, Elly Katabira, Nelly R Mugo, Jared M Baeten
BACKGROUND: PrEP is efficacious for African women at risk for HIV, but data on adherence outside of clinical trials are sparse. We describe the persistence and execution of PrEP use among women participating in a large open-label PrEP demonstration project, particularly during periods of HIV risk. SETTING: & Methods: 310 HIV-uninfected women in HIV serodiscordant couples in Kenya and Uganda were offered and accepted PrEP. Electronic monitoring caps were used to measure daily PrEP adherence...
September 29, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28991882/belief-in-treatment-as-prevention-and-its-relationship-to-hiv-status-and-behavioral-risk
#18
Kiffer G Card, Heather L Armstrong, Nathan J Lachowsky, Zishan Cui, Paul Sereda, M Allison Carter, Julio S G Montaner, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: We evaluated attitudes towards Treatment as Prevention (TasP) among gay, bisexual, and other men who have sex with men (GBM) in Vancouver, Canada. METHODS: Sexually-active GBM, aged >16, were recruited between 2012-2015 using respondentdriven sampling. At each six-month follow-up, participants completed a computer-administered questionnaire and nursing visit. Repeated measures latent class analysis (RMLCA), grouped by self-reported serostatus, identified patterns of TasP-endorsement by considering TasP-related awareness, attitudes, and behavior...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28975477/meta-analysis-of-alcohol-and-serodiscordant-condomless-sex-among-people-living-with-hiv
#19
Sarahmona M Przybyla, Gabriela Krawiec, Stephanie A Godleski, Cory A Crane
While observational studies have found that alcohol consumption is associated with serodiscordant condomless sex among people living with HIV (PLHIV), no meta-analysis has yet examined this trend. We conducted a meta-analysis to synthesize empirical evidence on the association between alcohol and condomless sex with partners at risk of HIV acquisition. To meet inclusion criteria, studies: (1) specifically targeted PLHIV or provided stratified data for HIV-infected participants; (2) provided a quantitative measure of alcohol use; (3) provided a quantitative measure of condomless sex with serodiscordant partners; and (4) reported the results of statistical tests examining the relationship between alcohol use and serodiscordant condomless sex...
October 3, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28966620/the-significance-of-discordant-serology-in-chagas-disease-enhanced-t-cell-immunity-to-trypanosoma-cruzi-in-serodiscordant-subjects
#20
Melisa D Castro Eiro, María G Alvarez, Gretchen Cooley, Rodolfo J Viotti, Graciela L Bertocchi, Bruno Lococo, María C Albareda, Ana M De Rissio, María A Natale, Cecilia Parodi, Rick L Tarleton, Susana A Laucella
BACKGROUND: Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from infected individuals among SD subjects. METHODS: Peripheral blood mononuclear cells from SD and seropositive (SP) subjects, who were born in areas endemic for T...
2017: Frontiers in Immunology
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