keyword
MENU ▼
Read by QxMD icon Read
search

Yvonne Lange

keyword
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#1
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
November 28, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27533038/biodiversity-at-multiple-trophic-levels-is-needed-for-ecosystem-multifunctionality
#2
Santiago Soliveres, Fons van der Plas, Peter Manning, Daniel Prati, Martin M Gossner, Swen C Renner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein, Klaus Birkhofer, Stefan Blaser, Nico Blüthgen, Steffen Boch, Stefan Böhm, Carmen Börschig, Francois Buscot, Tim Diekötter, Johannes Heinze, Norbert Hölzel, Kirsten Jung, Valentin H Klaus, Till Kleinebecker, Sandra Klemmer, Jochen Krauss, Markus Lange, E Kathryn Morris, Jörg Müller, Yvonne Oelmann, Jörg Overmann, Esther Pašalić, Matthias C Rillig, H Martin Schaefer, Michael Schloter, Barbara Schmitt, Ingo Schöning, Marion Schrumpf, Johannes Sikorski, Stephanie A Socher, Emily F Solly, Ilja Sonnemann, Elisabeth Sorkau, Juliane Steckel, Ingolf Steffan-Dewenter, Barbara Stempfhuber, Marco Tschapka, Manfred Türke, Paul C Venter, Christiane N Weiner, Wolfgang W Weisser, Michael Werner, Catrin Westphal, Wolfgang Wilcke, Volkmar Wolters, Tesfaye Wubet, Susanne Wurst, Markus Fischer, Eric Allan
Many experiments have shown that loss of biodiversity reduces the capacity of ecosystems to provide the multiple services on which humans depend. However, experiments necessarily simplify the complexity of natural ecosystems and will normally control for other important drivers of ecosystem functioning, such as the environment or land use. In addition, existing studies typically focus on the diversity of single trophic groups, neglecting the fact that biodiversity loss occurs across many taxa and that the functional effects of any trophic group may depend on the abundance and diversity of others...
August 25, 2016: Nature
https://www.readbyqxmd.com/read/27520733/biomaterials-influence-macrophage-mesenchymal-stem-cell-interaction-in-vitro
#3
Nienke Grotenhuis, Samantha F H De Witte, Gerjo J V M van Osch, Yves Bayon, Johan F Lange, Yvonne M Bastiaansen-Jenniskens
BACKGROUND: Macrophages and mesenchymal stem cells (MSCs) are important cells in wound healing. We hypothesized that the cross-talk between macrophages and adipose tissue-derived MSCs (ASCs) is biomaterial dependent, thereby influencing processes involved in wound healing. MATERIALS AND METHODS: The effect of macrophages cultured on polypropylene (PP) or polyethylene terephthalate coated with a collagen film (PET/Col) on ASCs in monolayer or on the same material was examined either through conditioned medium (CM) or in a direct coculture...
September 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27400928/sweat-it-out-the-effects-of-physical-exercise-on-cognition-and-behavior-in-children-and-adults-with-adhd-a-systematic-literature-review
#4
Anne E Den Heijer, Yvonne Groen, Lara Tucha, Anselm B M Fuermaier, Janneke Koerts, Klaus W Lange, Johannes Thome, Oliver Tucha
As attention-deficit/hyperactivity disorder (ADHD) is one of the most frequently diagnosed developmental disorders in childhood, effective yet safe treatment options are highly important. Recent research introduced physical exercise as a potential treatment option, particularly for children with ADHD. The aim of this review was to systematically analyze potential acute and chronic effects of cardio and non-cardio exercise on a broad range of functions in children with ADHD and to explore this in adults as well...
July 11, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27399589/-comparison-of-aggressive-behavior-compulsory-medication-and-absconding-behavior-between-open-and-closed-door-policy-in-an-acute-psychiatric-ward
#5
Mara-Lena Cibis, Carolin Wackerhagen, Sabine Müller, Undine E Lang, Yvonne Schmidt, Andreas Heinz
Objective: According to legal requirements coercive treatment must be limited to acts necessary for the protection of patients and cannot be used for institutional interests. Here, we aimed to test the hypothesis that opening psychiatric wards can reduce the number of aggressive assaults and of coercive treatment without increasing absconding rates. Methods: Numbers of absconding, coercive medication, fixation and special security actions were collected retrospectively and compared between phases of closed (N total = 409; N legally committed = 64) and 90 % of daytime opened (N total = 571; N legally committed = 99) doors in an acute psychiatric ward...
July 11, 2016: Psychiatrische Praxis
https://www.readbyqxmd.com/read/27161669/intravenous-lacosamide-in-clinical-practice-results-from-an-independent-registry
#6
Nicolas Lang, Max Lange, Friedhelm C Schmitt, Monika Bös, Yvonne Weber, Stefan Evers, Lothar Burghaus, Christoph Kellinghaus, Susanne Schubert-Bast, Julian Bösel, Thorsten Lammers, Michael Sabolek, Andreas van Baalen, Rainer Dziewas, Andrea Kraft, Susanne Ruf, Ulrich Stephani
PURPOSE: This non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide (LCM-iv) under routine conditions in daily clinical practice as a prospective registry. METHODS: Patients with any type of seizure or epilepsy syndrome were recruited in 16 neurological and neuropediatric centers in Germany if the treating physician decided to administer LCM-iv for any reason. Observation time per patient was 10 days with daily documentation of LCM-iv administration, type and frequency of seizures, currently used drugs and doses, and adverse events...
July 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27114572/locally-rare-species-influence-grassland-ecosystem-multifunctionality
#7
Santiago Soliveres, Peter Manning, Daniel Prati, Martin M Gossner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein, Klaus Birkhofer, Stefan Blaser, Nico Blüthgen, Steffen Boch, Stefan Böhm, Carmen Börschig, Francois Buscot, Tim Diekötter, Johannes Heinze, Norbert Hölzel, Kirsten Jung, Valentin H Klaus, Alexandra-Maria Klein, Till Kleinebecker, Sandra Klemmer, Jochen Krauss, Markus Lange, E Kathryn Morris, Jörg Müller, Yvonne Oelmann, Jörg Overmann, Esther Pašalić, Swen C Renner, Matthias C Rillig, H Martin Schaefer, Michael Schloter, Barbara Schmitt, Ingo Schöning, Marion Schrumpf, Johannes Sikorski, Stephanie A Socher, Emily F Solly, Ilja Sonnemann, Elisabeth Sorkau, Juliane Steckel, Ingolf Steffan-Dewenter, Barbara Stempfhuber, Marco Tschapka, Manfred Türke, Paul Venter, Christiane N Weiner, Wolfgang W Weisser, Michael Werner, Catrin Westphal, Wolfgang Wilcke, Volkmar Wolters, Tesfaye Wubet, Susanne Wurst, Markus Fischer, Eric Allan
Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity-multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land-use intensity (LUI) gradient...
May 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27094692/the-use-of-laser-guidance-reduces-fluoroscopy-time-for-c-arm-cone-beam-computed-tomography-guided-biopsies
#8
Maarten W Kroes, Marco J L van Strijen, Sicco J Braak, Yvonne L Hoogeveen, Frank de Lange, Leo J Schultze Kool
PURPOSE: When using laser guidance for cone-beam computed tomography (CBCT)-guided needle interventions, planned needle paths are visualized to the operator without the need to switch between entry- and progress-view during needle placement. The current study assesses the effect of laser guidance during CBCT-guided biopsies on fluoroscopy and procedure times. MATERIALS AND METHODS: Prospective data from 15 CBCT-guided biopsies of 8-65 mm thoracic and abdominal lesions assisted by a ceiling-mounted laser guidance technique were compared to retrospective data of 36 performed CBCT-guided biopsies of lesions >20 mm using the freehand technique...
September 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/26897552/does-familiarity-affect-the-enjoyment-of-touchscreen-games-for-people-with-dementia
#9
Arlene J Astell, Phil Joddrell, Hanny Groenewoud, Jacomine de Lange, Marleen Goumans, Anneloes Cordia, Yvonne Schikhof
INTRODUCTION: Previous research has indicated that people living with dementia are able to use touchscreen technology, which presents an opportunity to deliver meaningful and engaging activities for people to pass the time independently. The challenge is to identify suitable applications from the thousands that are currently available, and familiarity, where an app is a digital version of an existing real world game, may be one solution. OBJECTIVES: To evaluate the concept of familiarity in gameplay with people living with dementia by comparing a known game with a novel game and measuring whether users are able to play these games independently and whether they enjoy doing so...
July 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/26874289/active-membrane-cholesterol-as-a-physiological-effector
#10
Yvonne Lange, Theodore L Steck
Sterols associate preferentially with plasma membrane sphingolipids and saturated phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity of these polar bilayer lipids has a high accessibility and fugacity; we call this fraction active cholesterol. This review first considers how active cholesterol serves as an upstream regulator of cellular sterol homeostasis. The mechanism appears to utilize the redistribution of active cholesterol down its diffusional gradient to the endoplasmic reticulum and mitochondria, where it binds multiple effectors and directs their feedback activity...
September 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/26862468/the-effect-of-biomaterials-used-for-tissue-regeneration-purposes-on-polarization-of-macrophages
#11
REVIEW
Geesien S A Boersema, Nienke Grotenhuis, Yves Bayon, Johan F Lange, Yvonne M Bastiaansen-Jenniskens
Activation of macrophages is critical in the acute phase of wound healing after implantation of surgical biomaterials. To understand the response of macrophages, they are often cultured in vitro on biomaterials. Since a wide range of biomaterials is currently used in the clinics, we undertook a systematic review of the macrophage polarization in response to these different surgical biomaterials in vitro. Beside the chemistry, material characteristics such as dimension, pore size, and surface topography are of great influence on the response of macrophages...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/26774979/impaired-cued-and-spatial-learning-performance-and-altered-cannabinoid-cb%C3%A2-receptor-functionality-in-the-substantia-nigra-in-a-rat-model-of-diabetic-neuropathy
#12
Orla Moriarty, Yvonne Lang, Zubair Idrees, Brian E McGuire, David P Finn
Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and cognitive function in the rat streptozotocin (STZ) model of diabetes, and assessed cannabinoid1 (CB1) receptor functionality in discrete brain regions. Male Lister-Hooded rats received STZ (60 mg/kgs.c.) or vehicle. Sensory responses were assessed in von Frey and Hargreaves tests. Cognitive, motor and sensorimotor functions were assessed using novel object recognition and Morris water maze tasks...
April 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26721892/coated-platelets-function-in-platelet-dependent-fibrin-formation-via-integrin-%C3%AE-iib%C3%AE-3-and-transglutaminase-factor-xiii
#13
Nadine J A Mattheij, Frauke Swieringa, Tom G Mastenbroek, Michelle A Berny-Lang, Frauke May, Constance C F M J Baaten, Paola E J van der Meijden, Yvonne M C Henskens, Erik A M Beckers, Dennis P L Suylen, Marc W Nolte, Tilman M Hackeng, Owen J T McCarty, Johan W M Heemskerk, Judith M E M Cosemans
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding. Yet, their functional role has remained unclear. Here we used a novel transglutaminase probe, Rhod-A14, to identify a subpopulation of platelets with a cross-linked protein coat, and compared this with other platelet subpopulations using a panel of functional assays...
April 2016: Haematologica
https://www.readbyqxmd.com/read/26466568/telomerase-activation-by-genomic-rearrangements-in-high-risk-neuroblastoma
#14
Martin Peifer, Falk Hertwig, Frederik Roels, Daniel Dreidax, Moritz Gartlgruber, Roopika Menon, Andrea Krämer, Justin L Roncaioli, Frederik Sand, Johannes M Heuckmann, Fakhera Ikram, Rene Schmidt, Sandra Ackermann, Anne Engesser, Yvonne Kahlert, Wenzel Vogel, Janine Altmüller, Peter Nürnberg, Jean Thierry-Mieg, Danielle Thierry-Mieg, Aruljothi Mariappan, Stefanie Heynck, Erika Mariotti, Kai-Oliver Henrich, Christian Gloeckner, Graziella Bosco, Ivo Leuschner, Michal R Schweiger, Larissa Savelyeva, Simon C Watkins, Chunxuan Shao, Emma Bell, Thomas Höfer, Viktor Achter, Ulrich Lang, Jessica Theissen, Ruth Volland, Maral Saadati, Angelika Eggert, Bram de Wilde, Frank Berthold, Zhiyu Peng, Chen Zhao, Leming Shi, Monika Ortmann, Reinhard Büttner, Sven Perner, Barbara Hero, Alexander Schramm, Johannes H Schulte, Carl Herrmann, Roderick J O'Sullivan, Frank Westermann, Roman K Thomas, Matthias Fischer
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite intensive multimodal treatment, and their molecular basis has remained largely elusive. Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15...
October 29, 2015: Nature
https://www.readbyqxmd.com/read/26007735/surface-acoustic-wave-saw-resonators-for-monitoring-conditioning-film-formation
#15
Siegfried Hohmann, Svea Kögel, Yvonne Brunner, Barbara Schmieg, Christina Ewald, Frank Kirschhöfer, Gerald Brenner-Weiß, Kerstin Länge
We propose surface acoustic wave (SAW) resonators as a complementary tool for conditioning film monitoring. Conditioning films are formed by adsorption of inorganic and organic substances on a substrate the moment this substrate comes into contact with a liquid phase. In the case of implant insertion, for instance, initial protein adsorption is required to start wound healing, but it will also trigger immune reactions leading to inflammatory responses. The control of the initial protein adsorption would allow to promote the healing process and to suppress adverse immune reactions...
2015: Sensors
https://www.readbyqxmd.com/read/25884354/treatment-and-survival-of-non-alcoholic-steatohepatitis-associated-hepatocellular-carcinoma
#16
Arndt Weinmann, Yvonne Alt, Sandra Koch, Carina Nelles, Christoph Düber, Hauke Lang, Gerd Otto, Tim Zimmermann, Jens U Marquardt, Peter R Galle, Marcus A Wörns, Jörn M Schattenberg
BACKGROUND: The incidence of non-alcoholic steatohepatitis (NASH) is increasing worldwide and a poorly defined subset of patients develops end-stage liver disease and hepatocellular carcinoma (HCC). Differences in the biological behaviour, tumour characteristics, associated risk factors, treatment outcomes and overall survival of patients with NASH-HCC remain poorly defined. The aim of this study was to determine and analyze these differences in a large clinical cohort to guide treatment decisions...
2015: BMC Cancer
https://www.readbyqxmd.com/read/25793325/reducing-colorectal-anastomotic-leakage-with-tissue-adhesive-in-experimental-inflammatory-bowel-disease
#17
Zhouqiao Wu, Geesien S A Boersema, Leonard F Kroese, Diman Taha, Sandra Vennix, Yvonne M Bastiaansen-Jenniskens, King H Lam, Gert-Jan Kleinrensink, Johannes Jeekel, Maikel Peppelenbosch, Johan F Lange
BACKGROUND: Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis. METHODS: We first performed colectomy 7 days after 10 mg trinitrobenzene sulfonic acid (TNBS)-induced colitis to validate a rat TNBS-colitis-colectomy model...
May 2015: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/25382123/optimization-of-a-nonviral-transfection-system-to-evaluate-cox-2-controlled-interleukin-4-expression-for-osteoarthritis-gene-therapy-in-vitro
#18
Annemarie Lang, Johannes Neuhaus, Moritz Pfeiffenberger, Erik Schröder, Igor Ponomarev, Yvonne Weber, Timo Gaber, Michael F G Schmidt
BACKGROUND: Gene therapy appears to have the potential for achieving a long-term remedy for osteoarthritis (OA). However, there is a risk of adverse reactions, especially when using cytomegalovirus-controlled expression. To provide a safe application, we focused on the expression of therapeutic cytokines [e.g. interleukin (IL)-4] in a disease-responsive manner by use of the previously cloned Cox-2 promoter as 'genetic switch'. In the present study, we report the functionality of a controlled gene therapeutic system in an equine osteoarthritic cell model...
November 2014: Journal of Gene Medicine
https://www.readbyqxmd.com/read/25375235/nmr-based-detection-of-hydrogen-deuterium-exchange-in-liposome-embedded-membrane-proteins
#19
Xuejun Yao, Ulrich H N Dürr, Zrinka Gattin, Yvonne Laukat, Rhagavendran L Narayanan, Ann-Kathrin Brückner, Chris Meisinger, Adam Lange, Stefan Becker, Markus Zweckstetter
Membrane proteins play key roles in biology. Determination of their structure in a membrane environment, however, is highly challenging. To address this challenge, we developed an approach that couples hydrogen/deuterium exchange of membrane proteins to rapid unfolding and detection by solution-state NMR spectroscopy. We show that the method allows analysis of the solvent protection of single residues in liposome-embedded proteins such as the 349-residue Tom40, the major protein translocation pore in the outer mitochondrial membrane, which has resisted structural analysis for many years...
2014: PloS One
https://www.readbyqxmd.com/read/25262344/hmg-coenzyme-a-reductase-inhibition-type-2-diabetes-and-bodyweight-evidence-from-genetic-analysis-and-randomised-trials
#20
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen E L Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul C D Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene C W Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi G J Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John J V McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, W M Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS: We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes...
January 24, 2015: Lancet
keyword
keyword
19059
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"