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Yvonne Lange

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https://www.readbyqxmd.com/read/28628777/effects-of-adipose-stem-cell-sheets-on-colon-anastomotic-leakage-in-an-experimental-model-proof-of-principle
#1
Panithi Sukho, Geesien S A Boersema, Abigael Cohen, Nicole Kops, Johan F Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M Bastiaansen-Jenniskens, Femke Verseijden
The most dreaded complication of colorectal surgery is anastomotic leakage. Adipose tissue-derived stem cell sheets (ASC sheets) prepared from temperature-responsive culture surfaces can be easily transplanted onto tissues. These sheets are proposed to improve cell transplant efficiency and enhance wound healing. The aim of this study was to investigate whether application of ASC sheets could prevent leakage of sutured colorectal anastomoses. Insufficient suturing of colorectal anastomoses was performed in Wistar rats to create a colorectal anastomotic leakage model...
June 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/28614388/osteoblast-specific-overexpression-of-complement-receptor-c5ar1-impairs-fracture-healing
#2
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts. C5aR1 induces osteoblast migration, cytokine generation and osteoclastogenesis, however, the exact role of C5aR1-mediated signaling in osteoblasts is not entirely known. Therefore, we hypothesized that osteoblasts are essential target cells for C5a and that fracture healing should be disturbed in mice with an osteoblast-specific C5aR1 overexpression (Col1a1-C5aR1)...
2017: PloS One
https://www.readbyqxmd.com/read/28548707/phenotypes-and-genotypes-in-individuals-with-smc1a-variants
#3
Sylvia Huisman, Paul A Mulder, Egbert Redeker, Ingrid Bader, Anne-Marie Bisgaard, Alice Brooks, Anna Cereda, Constanza Cinca, Dinah Clark, Valerie Cormier-Daire, Matthew A Deardorff, Karin Diderich, Mariet Elting, Anthonie van Essen, David FitzPatrick, Cristina Gervasini, Gabriele Gillessen-Kaesbach, Katta M Girisha, Yvonne Hilhorst-Hofstee, Saskia Hopman, Denise Horn, Mala Isrie, Sandra Jansen, Cathrine Jespersgaard, Frank J Kaiser, Maninder Kaur, Tjitske Kleefstra, Ian D Krantz, Phillis Lakeman, Annemiek Landlust, Davor Lessel, Caroline Michot, Jo Moss, Sarah E Noon, Chris Oliver, Ilaria Parenti, Juan Pie, Feliciano J Ramos, Claudine Rieubland, Silvia Russo, Angelo Selicorni, Zeynep Tümer, Rieneke Vorstenbosch, Tara L Wenger, Ingrid van Balkom, Sigrid Piening, Jolanta Wierzba, Raoul C Hennekam
SMC1A encodes one of the proteins of the cohesin complex. SMC1A variants are known to cause a phenotype resembling Cornelia de Lange syndrome (CdLS). Exome sequencing has allowed recognizing SMC1A variants in individuals with encephalopathy with epilepsy who do not resemble CdLS. We performed an international, interdisciplinary study on 51 individuals with SMC1A variants for physical and behavioral characteristics, and compare results to those in 67 individuals with NIPBL variants. For the Netherlands all known individuals with SMC1A variants were studied, both with and without CdLS phenotype...
May 26, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28267684/in-vitro-modulation-of-the-behavior-of-adhering-macrophages-by-medications-is-biomaterial-dependent
#4
Lizette Utomo, Geesien S A Boersema, Yves Bayon, Johan F Lange, Gerjo J V M van Osch, Yvonne M Bastiaansen-Jenniskens
After implantation of a biomaterial, an inflammatory response involving macrophages is induced. The behavior of macrophages depends on their phenotype, and by directing macrophage polarization unwanted effects may be avoided. In this study, the possibility to modulate the behavior of macrophages activated by biomaterials was assessed in an in vitro model. Primary human monocytes were seeded on polyethylene terephthalate, polypropylene and polylactic acid yarns, and treated with medications frequently used by patients: rapamycin, dexamethasone, celecoxib or pravastatin...
March 7, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28255225/influence-of-different-patellofemoral-design-variations-based-on-genesis-ii-total-knee-endoprosthesis-on-patellofemoral-pressure-and-kinematics
#5
Ulf G Leichtle, Barbara Lange, Yvonne Herzog, Peter Schnauffer, Carmen I Leichtle, Nikolaus Wülker, Andrea Lorenz
In total knee arthroplasty (TKA), patellofemoral groove design varies greatly and likely has a distinct influence on patellofemoral biomechanics. To analyse the selective influence, five patellofemoral design variations were developed based on Genesis II total knee endoprosthesis (original design, being completely flat, being laterally elevated, being medially elevated, and both sides elevated) and made from polyamide using rapid prototyping. Muscle-loaded knee flexion was simulated on 10 human knee specimens using a custom-made knee simulator, measuring the patellofemoral pressure distribution and tibiofemoral and patellofemoral kinematics...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28186126/molecular-dissection-of-colorectal-cancer-in-pre-clinical-models-identifies-biomarkers-predicting-sensitivity-to-egfr-inhibitors
#6
Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans-Jörg Warnatz, Lee M Butcher, James E Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, Alberto Fusi, Thomas Kessler, Ralf Herwig, Ulf Landegren, Dirk Wienke, Mats Nilsson, Juan A Velasco, Pilar Garin-Chesa, Christoph Reinhard, Stephan Beck, Reinhold Schäfer, Christian R A Regenbrecht, David Henderson, Bodo Lange, Johannes Haybaeck, Ulrich Keilholz, Jens Hoffmann, Hans Lehrach, Marie-Laure Yaspo
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC...
February 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28017787/randomized-phase-iii-trial-of-erlotinib-versus-docetaxel-in-patients-with-advanced-squamous-cell-non-small-cell-lung-cancer-failing-first-line-platinum-based-doublet-chemotherapy-stratified-by%C3%A2-veristrat-good-versus-veristrat-poor-the-european%C3%A2-thoracic-oncology
#7
Solange Peters, Rolf A Stahel, Urania Dafni, Santiago Ponce Aix, Bartomeu Massutí, Oliver Gautschi, Linda Coate, Ana López Martín, Robbert van Heemst, Thierry Berghmans, Peter Meldgaard, Manuel Cobo Dols, Javier Garde Noguera, Alessandra Curioni-Fontecedro, Daniel Rauch, Michael T Mark, Sinead Cuffe, Bonne Biesma, Arjen M J van Henten, Óscar Juan Vidal, Ramón Palmero Sanchez, José Carlos Villa Guzmán, Ricardo Collado Martin, Sergio Peralta, Amelia Insa, Yvonne Summers, István Láng, Anne Horgan, Fortunato Ciardiello, Sander de Hosson, Remge Pieterman, Harry J M Groen, Paul M van den Berg, Christoph C Zielinski, Yojena Chittazhathu Kurian Kuruvilla, Adriana Gasca-Ruchti, Marie Kassapian, Silvia Novello, Valter Torri, Zoi Tsourti, Vanesa Gregorc, Egbert F Smit
INTRODUCTION: Docetaxel and erlotinib are registered second-line treatments for wild-type EGFR NSCLC. Previous studies suggested a predictive value of the VeriStrat test in second-line therapy of NSCLC, classifying patients as either VeriStrat good or VeriStrat poor. EMPHASIS-lung aimed at exploring this predictive effect in patients with squamous cell NSCLC. The trial closed prematurely because of low accrual and results from other trials. Our analysis includes an exploratory combined analysis with results from the PROSE trial...
April 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27942926/laser-guidance-in-c-arm-cone-beam-ct-guided%C3%A2-radiofrequency-ablation-of-osteoid-osteoma-reduces-fluoroscopy-time
#8
Maarten W Kroes, Wendy M H Busser, Yvonne L Hoogeveen, Frank de Lange, Leo J Schultze Kool
PURPOSE: To assess whether laser guidance can reduce fluoroscopy and procedure time of cone-beam computed tomography (CBCT)-guided radiofrequency (RF) ablations of osteoid osteoma compared to freehand CBCT guidance. MATERIALS AND METHODS: 32 RF ablations were retrospectively analyzed, 17 laser-guided and 15 procedures using the freehand technique. Subgroup selection of 18 ablations in the hip-pelvic region with a similar degree of difficulty was used for a direct comparison...
May 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#9
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O'Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
February 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27533038/biodiversity-at-multiple-trophic-levels-is-needed-for-ecosystem-multifunctionality
#10
Santiago Soliveres, Fons van der Plas, Peter Manning, Daniel Prati, Martin M Gossner, Swen C Renner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein, Klaus Birkhofer, Stefan Blaser, Nico Blüthgen, Steffen Boch, Stefan Böhm, Carmen Börschig, Francois Buscot, Tim Diekötter, Johannes Heinze, Norbert Hölzel, Kirsten Jung, Valentin H Klaus, Till Kleinebecker, Sandra Klemmer, Jochen Krauss, Markus Lange, E Kathryn Morris, Jörg Müller, Yvonne Oelmann, Jörg Overmann, Esther Pašalić, Matthias C Rillig, H Martin Schaefer, Michael Schloter, Barbara Schmitt, Ingo Schöning, Marion Schrumpf, Johannes Sikorski, Stephanie A Socher, Emily F Solly, Ilja Sonnemann, Elisabeth Sorkau, Juliane Steckel, Ingolf Steffan-Dewenter, Barbara Stempfhuber, Marco Tschapka, Manfred Türke, Paul C Venter, Christiane N Weiner, Wolfgang W Weisser, Michael Werner, Catrin Westphal, Wolfgang Wilcke, Volkmar Wolters, Tesfaye Wubet, Susanne Wurst, Markus Fischer, Eric Allan
Many experiments have shown that loss of biodiversity reduces the capacity of ecosystems to provide the multiple services on which humans depend. However, experiments necessarily simplify the complexity of natural ecosystems and will normally control for other important drivers of ecosystem functioning, such as the environment or land use. In addition, existing studies typically focus on the diversity of single trophic groups, neglecting the fact that biodiversity loss occurs across many taxa and that the functional effects of any trophic group may depend on the abundance and diversity of others...
August 25, 2016: Nature
https://www.readbyqxmd.com/read/27520733/biomaterials-influence-macrophage-mesenchymal-stem-cell-interaction-in-vitro
#11
Nienke Grotenhuis, Samantha F H De Witte, Gerjo J V M van Osch, Yves Bayon, Johan F Lange, Yvonne M Bastiaansen-Jenniskens
BACKGROUND: Macrophages and mesenchymal stem cells (MSCs) are important cells in wound healing. We hypothesized that the cross-talk between macrophages and adipose tissue-derived MSCs (ASCs) is biomaterial dependent, thereby influencing processes involved in wound healing. MATERIALS AND METHODS: The effect of macrophages cultured on polypropylene (PP) or polyethylene terephthalate coated with a collagen film (PET/Col) on ASCs in monolayer or on the same material was examined either through conditioned medium (CM) or in a direct coculture...
September 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27400928/sweat-it-out-the-effects-of-physical-exercise-on-cognition-and-behavior-in-children-and-adults-with-adhd-a-systematic-literature-review
#12
REVIEW
Anne E Den Heijer, Yvonne Groen, Lara Tucha, Anselm B M Fuermaier, Janneke Koerts, Klaus W Lange, Johannes Thome, Oliver Tucha
As attention-deficit/hyperactivity disorder (ADHD) is one of the most frequently diagnosed developmental disorders in childhood, effective yet safe treatment options are highly important. Recent research introduced physical exercise as a potential treatment option, particularly for children with ADHD. The aim of this review was to systematically analyze potential acute and chronic effects of cardio and non-cardio exercise on a broad range of functions in children with ADHD and to explore this in adults as well...
February 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27399589/-comparison-of-aggressive-behavior-compulsory-medication-and-absconding-behavior-between-open-and-closed-door-policy-in-an-acute-psychiatric-ward
#13
Mara-Lena Cibis, Carolin Wackerhagen, Sabine Müller, Undine E Lang, Yvonne Schmidt, Andreas Heinz
Objective According to legal requirements coercive treatment must be limited to acts necessary for the protection of patients and cannot be used for institutional interests. Here, we aimed to test the hypothesis that opening psychiatric wards can reduce the number of aggressive assaults and of coercive treatment without increasing absconding rates. Methods Numbers of absconding, coercive medication, fixation and special security actions were collected retrospectively and compared between phases of closed (N total = 409; N legally committed = 64) and 90 % of daytime opened (N total = 571; N legally committed = 99) doors in an acute psychiatric ward...
April 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/27161669/intravenous-lacosamide-in-clinical-practice-results-from-an-independent-registry
#14
Nicolas Lang, Max Lange, Friedhelm C Schmitt, Monika Bös, Yvonne Weber, Stefan Evers, Lothar Burghaus, Christoph Kellinghaus, Susanne Schubert-Bast, Julian Bösel, Thorsten Lammers, Michael Sabolek, Andreas van Baalen, Rainer Dziewas, Andrea Kraft, Susanne Ruf, Ulrich Stephani
PURPOSE: This non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide (LCM-iv) under routine conditions in daily clinical practice as a prospective registry. METHODS: Patients with any type of seizure or epilepsy syndrome were recruited in 16 neurological and neuropediatric centers in Germany if the treating physician decided to administer LCM-iv for any reason. Observation time per patient was 10 days with daily documentation of LCM-iv administration, type and frequency of seizures, currently used drugs and doses, and adverse events...
July 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27114572/locally-rare-species-influence-grassland-ecosystem-multifunctionality
#15
Santiago Soliveres, Peter Manning, Daniel Prati, Martin M Gossner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein, Klaus Birkhofer, Stefan Blaser, Nico Blüthgen, Steffen Boch, Stefan Böhm, Carmen Börschig, Francois Buscot, Tim Diekötter, Johannes Heinze, Norbert Hölzel, Kirsten Jung, Valentin H Klaus, Alexandra-Maria Klein, Till Kleinebecker, Sandra Klemmer, Jochen Krauss, Markus Lange, E Kathryn Morris, Jörg Müller, Yvonne Oelmann, Jörg Overmann, Esther Pašalić, Swen C Renner, Matthias C Rillig, H Martin Schaefer, Michael Schloter, Barbara Schmitt, Ingo Schöning, Marion Schrumpf, Johannes Sikorski, Stephanie A Socher, Emily F Solly, Ilja Sonnemann, Elisabeth Sorkau, Juliane Steckel, Ingolf Steffan-Dewenter, Barbara Stempfhuber, Marco Tschapka, Manfred Türke, Paul Venter, Christiane N Weiner, Wolfgang W Weisser, Michael Werner, Catrin Westphal, Wolfgang Wilcke, Volkmar Wolters, Tesfaye Wubet, Susanne Wurst, Markus Fischer, Eric Allan
Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity-multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land-use intensity (LUI) gradient...
May 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27094692/the-use-of-laser-guidance-reduces-fluoroscopy-time-for-c-arm-cone-beam-computed-tomography-guided-biopsies
#16
Maarten W Kroes, Marco J L van Strijen, Sicco J Braak, Yvonne L Hoogeveen, Frank de Lange, Leo J Schultze Kool
PURPOSE: When using laser guidance for cone-beam computed tomography (CBCT)-guided needle interventions, planned needle paths are visualized to the operator without the need to switch between entry- and progress-view during needle placement. The current study assesses the effect of laser guidance during CBCT-guided biopsies on fluoroscopy and procedure times. MATERIALS AND METHODS: Prospective data from 15 CBCT-guided biopsies of 8-65 mm thoracic and abdominal lesions assisted by a ceiling-mounted laser guidance technique were compared to retrospective data of 36 performed CBCT-guided biopsies of lesions >20 mm using the freehand technique...
September 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/26897552/does-familiarity-affect-the-enjoyment-of-touchscreen-games-for-people-with-dementia
#17
RANDOMIZED CONTROLLED TRIAL
Arlene J Astell, Phil Joddrell, Hanny Groenewoud, Jacomine de Lange, Marleen Goumans, Anneloes Cordia, Yvonne Schikhof
INTRODUCTION: Previous research has indicated that people living with dementia are able to use touchscreen technology, which presents an opportunity to deliver meaningful and engaging activities for people to pass the time independently. The challenge is to identify suitable applications from the thousands that are currently available, and familiarity, where an app is a digital version of an existing real world game, may be one solution. OBJECTIVES: To evaluate the concept of familiarity in gameplay with people living with dementia by comparing a known game with a novel game and measuring whether users are able to play these games independently and whether they enjoy doing so...
July 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/26874289/active-membrane-cholesterol-as-a-physiological-effector
#18
REVIEW
Yvonne Lange, Theodore L Steck
Sterols associate preferentially with plasma membrane sphingolipids and saturated phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity of these polar bilayer lipids has a high accessibility and fugacity; we call this fraction active cholesterol. This review first considers how active cholesterol serves as an upstream regulator of cellular sterol homeostasis. The mechanism appears to utilize the redistribution of active cholesterol down its diffusional gradient to the endoplasmic reticulum and mitochondria, where it binds multiple effectors and directs their feedback activity...
September 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/26862468/the-effect-of-biomaterials-used-for-tissue-regeneration-purposes-on-polarization-of-macrophages
#19
REVIEW
Geesien S A Boersema, Nienke Grotenhuis, Yves Bayon, Johan F Lange, Yvonne M Bastiaansen-Jenniskens
Activation of macrophages is critical in the acute phase of wound healing after implantation of surgical biomaterials. To understand the response of macrophages, they are often cultured in vitro on biomaterials. Since a wide range of biomaterials is currently used in the clinics, we undertook a systematic review of the macrophage polarization in response to these different surgical biomaterials in vitro. Beside the chemistry, material characteristics such as dimension, pore size, and surface topography are of great influence on the response of macrophages...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/26774979/impaired-cued-and-spatial-learning-performance-and-altered-cannabinoid-cb%C3%A2-receptor-functionality-in-the-substantia-nigra-in-a-rat-model-of-diabetic-neuropathy
#20
Orla Moriarty, Yvonne Lang, Zubair Idrees, Brian E McGuire, David P Finn
Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and cognitive function in the rat streptozotocin (STZ) model of diabetes, and assessed cannabinoid1 (CB1) receptor functionality in discrete brain regions. Male Lister-Hooded rats received STZ (60 mg/kgs.c.) or vehicle. Sensory responses were assessed in von Frey and Hargreaves tests. Cognitive, motor and sensorimotor functions were assessed using novel object recognition and Morris water maze tasks...
April 15, 2016: Behavioural Brain Research
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