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https://www.readbyqxmd.com/read/29161805/robot-assisted-radical-cystectomy-with-totally-intracorporeal-urinary-diversion-initial-single-surgeon-s-experience-after-a-modified-modular-training
#1
Angelo Porreca, Francesco Chessa, Daniele Romagnoli, Antonio Salvaggio, Angelo Cafarelli, Marco Borghesi, Lorenzo Bianchi, Matteo Dandrea, Daniele D'Agostino, Donato Dente, Emanuele Cappa, Peter Wiklund, Eugenio Brunocilla, Riccardo Schiavina
BACKGROUND: To report the perioperative and early functional outcomes of patients undergoing Robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion performed by a single surgeon after a modified modular training. METHODS: The surgeon (A.P.) attained a 30-days modified modular training at a referring Centre mentored by a worldwide-recognized robotic surgeon (P.W.). The training program consisted of: a) e-learning based on 10 hours of theoretical lessons made by the mentor; b) video-session concerning the different steps of the procedure, c) step-by-step in vivo modular training...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29161698/a-comparison-of-three-methods-for-the-detection-of-circulating-tumor-cells-in-patients-with-early-and-metastatic-breast-cancer
#2
Eleni Politaki, Sofia Agelaki, Stella Apostolaki, Dora Hatzidaki, Areti Strati, Filippos Koinis, Maria Perraki, Georgia Saloustrou, Giannis Stoupis, Galatea Kallergi, Maria Spiliotaki, Tereza Skaltsi, Evi Lianidou, Vassilis Georgoulias, Dimitrios Mavroudis
BACKGROUND: We directly compared CTC detection rates and prognostic significance, using three different methods in patients with breast cancer (BC). METHODS: Early (n=200) and metastatic (n=164) patients were evaluated before initiating adjuvant or first-line chemotherapy, using the CellSearchTM System, an RT-qPCR for CK-19 mRNA detection and by double immunofluorescence (IF) microscopy using A45-B/B3 and CD45 antibodies. RESULTS: Using the CellSearchTM System, 37% and 16...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161686/impact-of-an-in-hospital-patient-education-program-on-choice-of-renal-replacement-modality-in-unplanned-dialysis-initiation
#3
Moritz Schanz, Markus Ketteler, Markus Heck, Juergen Dippon, Mark Dominik Alscher, Martin Kimmel
BACKGROUND/AIMS: Up to 50% patients requiring dialysis receive an urgent, unplanned start (UPS) to renal replacement therapy (RRT). Most of these are initiated with an intravenous catheter and commenced and maintained on hemodialysis (HD). Although peritoneal dialysis (PD) could be an equipotent initial modality for RRT, it is used less frequently as long-term RRT in UPS patients. This multicenter-study aimed to evaluate the impact of a structured, in-hospital education program and factors influencing PD rates, especially in UPS patients...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29161668/patterns-of-c-reactive-protein-ratio-response-to-antibiotics-in-pediatric-sepsis-a-prospective-cohort-study
#4
Vanessa Soares Lanziotti, Pedro Póvoa, Arnaldo Prata-Barbosa, Lucas Berbet Pulcheri, Ligia S C F Rabello, José Roberto Lapa E Silva, Marcio Soares, Jorge I F Salluh
PURPOSE: Evaluate sequential C-reactive protein (CRP) measurements and patterns of CRP-ratio response to antibiotic therapy during first 7days in Pediatric Intensive Care Unit (PICU) of septic children. METHODS: Prospective, cohort study of children (1month-12years) admitted at 3 PICUs, with diagnosis of sepsis with <72h course. CRP-ratio was calculated in relation to D0_CRP value. Children were classified according to an individual pattern of CRP-ratio response: fast - CRP_D4 of therapy was <0...
November 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161659/lipopolysaccharide-lps-mediated-priming-of-toll-like-receptor-4-enhances-oxidant-induced-prostaglandin-e2-biosynthesis-in-primary-murine-macrophages
#5
Yan Zhang, Orisa J Igwe
Agonists and pseudo-agonists for toll-like receptor 4 (TLR4) are common in our environment. Thus, human exposure to these agents may result in "priming or sensitization" of TLR4. A body of evidence suggests that LPS-mediated sensitization of TLR4 can increase the magnitude of responses to exogenous agents in multiple tissues. We have previously shown that reactive oxygen and nitrogen species (RONS) stimulate TLR4. There is no evidence that LPS-primed TLR4 can influence the magnitude of responses to oxidants from either endogenous or exogenous sources...
November 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29161644/treatment-of-industrial-estate-wastewater-by-the-application-of-electrocoagulation-process-using-iron-electrodes
#6
Y Yavuz, Ü B Ögütveren
In this study electrocoagulation (EC) of industrial estate wastewater taken from the inlet of wastewater treatment plant was investigated using sacrificial iron electrodes. Employing a pole changer to homogenous consumption of electrodes, studies on the parameters such as current density, supporting electrolyte concentration and initial pH, which have significant effects on COD removal and hence the energy consumption, were performed. Hydrogen peroxide was used in different concentrations to observe its effects on COD removal efficiency and the energy consumption...
November 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29161621/human-subthalamic-oscillatory-dynamics-following-somatosensory-stimulation
#7
Saskia Elben, Carlos Trenado, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
OBJECTIVE: Electrical median nerve somatosensory stimulation leads to a distinct modulation of cortical oscillations. Initial high frequency and gamma augmentation, as well as modulation of beta and alpha oscillations have been reported. We aimed at investigating the involvement of the subthalamic nucleus in somatosensory processing by means of local field potential recordings, since recordings during passive movements and peripheral somatosensory stimulation have suggested a prominent role...
October 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29161604/ecological-effects-and-potential-risks-of-the-water-diversion-project-in-the-heihe-river-basin
#8
Mengmeng Zhang, Shuai Wang, Bojie Fu, Guangyao Gao, Qin Shen
To curb the severe ecological deterioration in the lower Heihe River Basin (HRB) in northwest China, a water diversion project was initiated in 2000. A comprehensive analysis of the ecological effects and potential risks associated with the project is needed. We assessed the hydrological and ecological achievements, and also analyzed the potential problems after the project was completed. We found that since the project began the hydrological regime has changed, with more than 57.82% of the upstream water being discharged to the lower reaches on average...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161603/-37-cl-compound-specific-isotope-analysis-and-assessment-of-functional-genes-for-monitoring-monochlorobenzene-mcb-biodegradation-under-aerobic-conditions
#9
Massimo Marchesi, Luca Alberti, Orfan Shouakar-Stash, Ilaria Pietrini, Francesca de Ferra, Giovanna Carpani, Ramon Aravena, Andrea Franzetti, Tatiana Stella
A laboratory approach was adopted in this study to explore the potential of (37)Cl-CSIA in combination with (13)C-CSIA and Biological Molecular Tools (BMTs) to estimate the occurrence of monochloroenzene (MCB) aerobic biodegradation. A new analytical method for (37)Cl-CSIA of MCB was developed in this study. This methodology using a GC-IRMS allowed to determine δ(37)Cl values within an internal error of ±0.3‰. Samples from a heavily MCB contaminated site were collected and MCB aerobic biodegradation microcosms with indigenous cultures in natural and enhanced conditions were set up...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161601/characterizing-emission-rates-of-regulated-pollutants-from-model-year-2012-heavy-duty-diesel-vehicles-equipped-with-dpf-and-scr-systems
#10
Yu Jiang, Jiacheng Yang, David Cocker, Georgios Karavalakis, Kent C Johnson, Thomas D Durbin
The regulated emissions of five 2012 and newer, low-mileage, heavy-duty Class 8 diesel trucks equipped with diesel particulate filters (DPFs) and selective catalytic reduction (SCR) systems were evaluated over test cycles representing urban, highway, and stop-and-go driving on a chassis dynamometer. NOx emissions over the Urban Dynamometer Driving Schedule (UDDS) ranged from 0.495 to 1.363g/mi (0.136 to 0.387g/bhp-hr) for four of the normal emitting trucks. For those trucks, NOx emissions were lowest over the cruise (0...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161581/dna-rna-hybrid-substrates-modulate-the-catalytic-activity-of-purified-aid
#11
Hala S Abdouni, Justin J King, Atefeh Ghorbani, Heather Fifield, Lesley Berghuis, Mani Larijani
Activation-induced cytidine deaminase (AID) converts cytidine to uridine at Immunoglobulin (Ig) loci, initiating somatic hypermutation and class switching of antibodies. In vitro, AID acts on single stranded DNA (ssDNA), but neither double-stranded DNA (dsDNA) oligonucleotides nor RNA, and it is believed that transcription is the in vivo generator of ssDNA targeted by AID. It is also known that the Ig loci, particularly the switch (S) regions targeted by AID are rich in transcription-generated DNA/RNA hybrids...
November 18, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29161580/artificial-intelligence-and-deep-learning-radiology-s-next-frontier
#12
REVIEW
Ray Cody Mayo, Jessica Leung
Tracing the use of computers in the radiology department from administrative functions through image acquisition, storage, and reporting, to early attempts at improved diagnosis, we begin to imagine possible new frontiers for their use in exam interpretation. Given their initially slow but ultimately substantial progress in the noninterpretive areas, we are left desiring and even expecting more in the interpretation realm. New technological advances may provide the next wave of progress and radiologists should be early adopters...
November 18, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29161540/delirium-symptoms-are-associated-with-decline-in-cognitive-function-between-ages-53-and-69-years-findings-from-a-british-birth-cohort-study
#13
A Tsui, D Kuh, M Richards, D Davis
INTRODUCTION: Few population studies have investigated whether longitudinal decline after delirium in mid-to-late life might affect specific cognitive domains. METHODS: Participants from a birth cohort completing assessments of search speed, verbal memory, and the Addenbrooke's Cognitive Examination at age 69 were asked about delirium symptoms between ages 60 and 69 years. Linear regression models estimated associations between delirium symptoms and cognitive outcomes...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29161532/the-role-of-paternity-acknowledgment-in-breastfeeding-noninitiation
#14
Jordyn T Wallenborn, Gregory J Chambers, Saba W Masho
BACKGROUND: In the United States, less than a quarter of mothers breastfeed in accordance with national recommendations. To date, researchers have demonstrated that paternal support directly influences breastfeeding outcomes; however, healthcare practitioners may not be able to quantify a lack of support in the immediate postpartum period. Research aim: The aim is to investigate the relationship between breastfeeding noninitiation and paternity acknowledgment, a factor that can be easily identified in the immediate postpartum period...
November 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29161522/development-of-a-measure-to-assess-parent-perceptions-of-barriers-to-child-weight-management
#15
Katherine E Darling, Amy F Sato, Manfred van Dulmen, Christopher Flessner, Geoffrey Putt
BACKGROUND: Families face many barriers related to creating or maintaining a healthy lifestyle, which likely contributes to the prevalence of childhood obesity in the United States; however, no measure currently exists to examine these barriers. This study developed a quantitative measure of parents' perceptions of barriers to family healthy lifestyle. METHODS: Parents of children between the ages of 7-17 were recruited using Amazon Mturk (n = 812). Exploratory and confirmatory factor analyses and preliminary convergent validity analyses were conducted...
November 21, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29161497/three-dimensional-microstructured-poly-vinyl-alcohol-hydrogel-platform-for-the-controlled-formation-of-multicellular-cell-spheroids
#16
Xiao-Qiu Dou, Ping Li, Holger Schönherr
Three-dimensional (3D) multicellular cell spheroids (MCSs) are excellent in vitro cell models, in which e.g. the in vivo cell-cell interaction processes are much better mimicked than in conventional two-dimensional (2D) cell layers. However, the difficulties in the generation of well-defined MCSs with controlled size severely limit their application. Herein, low-adhesive poly(vinyl alcohol) (PVA) hydrogels structured with inverted pyramid-shaped microwells were used to guide the aggregation of cells into MCSs...
November 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29161472/a-young-child-with-fever-alopecia-and-skin-nodules-a-clinicopathological-conference
#17
Pandiarajan Vignesh, Aman Gupta, Deepti Suri, Debajyoti Chatterjee, Uma Nahar Saikia, Amita Trehan, Surjit Singh
The illness started as a continuous high-grade fever noted up to 103°F.. Subsequently, he also developed red painful skin nodules that initially appeared over shins and later progressed to involve thighs, trunks, upper extremities, and face. The nodules also appeared over scalp and there was a was a progressive loss of scalp hair. This article is protected by copyright. All rights reserved.
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29161461/ruthenium-crosslinked-hydrogels-with-rapid-visible-light-degradation
#18
Teresa Rapp, Chris Highley, Brian Manor, Jason Burdick, Ivan J Dmochowski
Incorporation of photoresponsive molecules within soft materials can provide spatiotemporal control over bulk properties, and address challenges in targeted delivery and mechanical variability. However, the kinetics of in situ photochemical reactions are often slow and typically employ ultraviolet wavelengths. Here, we present a novel photoactive crosslinker Ru(bipyridine)2(3-pyridinaldehyde)2 (RuAldehyde), which was reacted with hydrazide-functionalized hyaluronic acid to form hydrogels capable of encapsulating protein cargo...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29161460/wnt-signaling-related-to-subchondral-bone-density-and-cartilage-degradation-in-oa
#19
EDITORIAL
David B Burr, Achint Utreja
The role of subchondral bone in the progression of osteoarthritis has been controversial for nearly 50 years.((1,2)) The observation that subchondral sclerosis was nearly always present in end-stage disease led to the conclusion that the increased stiffness caused by a thicker subchondral bone plate detracted from the bone's ability to attenuate the loads imposed on the joint cartilage, increasing cartilage stresses and initiating the process of joint deterioration. Because cartilage damage does not always progress to full thickness cartilage loss and OA, Radin and Rose((3)) proposed that the initiation and the progression of cartilage deterioration were separate processes...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161458/proton-pump-inhibitors-for-functional-dyspepsia
#20
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Ahmed Hassan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
November 21, 2017: Cochrane Database of Systematic Reviews
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