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https://www.readbyqxmd.com/read/28646773/survival-outcomes-of-patients-with-lobular-carcinoma-in-situ-who-underwent-bilateral-mastectomy-or-partial-mastectomy
#1
Ze-Ming Xie, Jian Sun, Zhe-Yu Hu, Yao-Pan Wu, Peng Liu, Jun Tang, Xiang-Sheng Xiao, Wei-Dong Wei, Xi Wang, Xiao-Ming Xie, Ming-Tian Yang
AIM: To compare the survival outcomes between patients treated with bilateral mastectomy and partial mastectomy alone as the initial surgical management for primary lobular carcinoma in situ (LCIS). PATIENTS AND METHODS: Patients with histologically confirmed LCIS underwent partial mastectomy alone or bilateral mastectomy were identified by the SEER*Stat database (version 8.3.2) released in 2016. The primary outcome measure was all-cause mortality and the secondary outcome measure was breast cancer-specific mortality...
June 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28646767/enhanced-photodegradation-of-2-4-dichlorophenoxyacetic-acid-using-a-novel-tio2-mgfe2o4-core-shell-structure
#2
Bui The Huy, Da-Som Jung, Nguyen Thi Kim Phuong, Yong-Ill Lee
A novel TiO2@MgO-Fe2O3 core-shell structure has been synthesized via a hydrolysis and co-precipitation method followed by calcination at 500 °C and has proven to be an efficient photocatalyst. The obtained TiO2@MgO-Fe2O3 core-shell was characterized by scanning electron microscopy, X-ray diffraction, and UV-Vis diffused reflectance techniques. Its photocatalytic activity toward 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated in aqueous solutions with and without visible light irradiation in the presence and absence of hydrogen peroxide...
June 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28646759/free-standing-graphene-vanadium-oxide-composite-as-binder-free-electrode-for-asymmetrical-supercapacitor
#3
Lingjuan Deng, Yihong Gao, Zhanying Ma, Guang Fan
Preparation of free-standing electrode materials with three-dimensional network architecture has emerged as an effective strategy for acquiring advanced portable and wearable power sources. Herein, graphene/vanadium oxide (GR/V2O5) free-standing monolith composite has been prepared via a simple hydrothermal process. Flexible GR sheets acted as binder to connect the belt-like V2O5 for assembling three-dimensional network architecture. The obtained GR/V2O5 composite can be reshaped into GR/V2O5 flexible film which exhibits more compact structure by ultrasonication and vacuum filtration...
June 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28646754/free-energy-analysis-of-cell-spreading
#4
Eóin McEvoy, Vikram S Deshpande, Patrick McGarry
In this study we present a steady-state adaptation of the thermodynamically motivated stress fiber (SF) model of Vigliotti et al. (2015). We implement this steady-state formulation in a non-local finite element setting where we also consider global conservation of the total number of cytoskeletal proteins within the cell, global conservation of the number of binding integrins on the cell membrane, and adhesion limiting ligand density on the substrate surface. We present a number of simulations of cell spreading in which we consider a limited subset of the possible deformed spread-states assumed by the cell in order to examine the hypothesis that free energy minimization drives the process of cell spreading...
June 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28646744/systematic-biobanking-novel-imaging-techniques-and-advanced-molecular-analysis-for-precise-tumor-diagnosis-and-therapy-the-polish-mobit-project
#5
Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L Abba, Hartmut Juhl, Frauke Koch
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized...
June 21, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28646727/pulmonary-embolism-prognostic-factors-and-length-of-hospital-stay-a-cohort-study
#6
Marco Paolo Donadini, Francesco Dentali, Marco Castellaneta, Paola Gnerre, Micaela La Regina, Luca Masotti, Filippo Pieralli, Fulvio Pomero, Roberta Re, Luigina Guasti, Walter Ageno, Alessandro Squizzato
INTRODUCTION: Patients with pulmonary embolism (PE) are commonly admitted to hospital for their initial treatment. We aimed to assess the association of length of hospital stay with commonly available clinical variables and their combinations. METHODS: A retrospective multicenter cohort study was conducted on consecutive PE patients admitted to eight Italian centers. Logistic regression analysis was performed to evaluate the association between the length of hospital stay and the Pulmonary Embolism Severity Index (PESI) parameters, National Early Warning Score (NEWS) and other possible determinants...
June 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28646720/nanoporous-gold-based-microbial-biosensor-for-direct-determination-of-sulfide
#7
Zhuang Liu, Hanyue Ma, Huihui Sun, Rui Gao, Honglei Liu, Xia Wang, Ping Xu, Luying Xun
Environmental pollution caused by sulfide compounds has become a major problem for public health. Hence, there is an urgent need to explore a sensitive, selective, and simple sulfide detection method for environmental monitoring and protection. Here, a novel microbial biosensor was developed using recombinant Escherichia coli BL21 (E. coli BL21) expressing sulfide:quinone oxidoreductase (SQR) for sulfide detection. As an important enzyme involved in the initial step of sulfide metabolism, SQR oxidizes sulfides to polysulfides and transfers electrons to the electron transport chain...
June 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28646711/effect-of-memantine-on-c-reactive-protein-and-lipid-profiles-in-bipolar-disorder
#8
Hui Hua Chang, Po See Chen, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, San-Yuan Huang, Jau-Shyong Hong, Yen Kuang Yang, Ru-Band Lu
BACKGROUND: Balance in the immune system plays roles in bipolar disorder (BD) and its metabolic co-morbidities. Memantine is an NMDA receptor antagonist with anti-inflammatory effects. However, the effects of memantine adjunct treatment on metabolic status of BD are unclear. METHODS: During the 12 weeks period, a total of 191 BD patients were enrolled and split into valproate (VPA) + placebo and VPA + memantine (5mg/day) arms. The fasting plasma levels of high-sensitivity C-reactive protein (CRP) and metabolic indices were assessed...
June 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28646701/use-of-sglt2-inhibitors-for-diabetes-and-risk-of-infection-analysis-using-general-practice-records-from-the-nps-medicinewise-medicineinsight-program
#9
Svetla Gadzhanova, Nicole Pratt, Elizabet Roughead
AIMS: To explore the feasibility of MedicineInsight data to support risk management plan evaluation, focusing on sodium glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes. METHODS: A retrospective study using de-identified electronic general practitioner records. Patients who initiated SGLT2 inhibitor between 1 Jan 2012 to 1 Sep 2015 were compared to patients who initiated dipeptidyl peptidase 4 (DPP-4) inhibitors. The two cohorts were followed-up for six months...
June 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28646682/sensing-nadh-conformation-using-phasor-analysis-on-fluorescence-spectra
#10
Dylan Palo, Jeff Maltas, Laxmi Risal, Paul Urayama
Phasor analysis on fluorescence signals is a sensitive approach for analyzing multicomponent systems. Initially developed for time-resolved measurements, a spectral version has been used for the rapid identification of regions during the spectral imaging of biological systems. Here we show that quantitative information regarding conformation can be obtained from phasor analysis of fluorescence spectrum shape. Methanol denaturation of NADH and NADH binding to various dehydrogenase proteins are used as model reactions...
June 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28646679/hypoxia-induced-adam-17-expression-is-mediated-by-rsk1-dependent-c-ebp%C3%AE-activation-in-human-lung-fibroblasts
#11
Jing-Yun Chen, Chien-Huang Lin, Bing-Chang Chen
Hypoxia was identified as a mediator of lung fibrosis in patients with chronic obstructive asthma (COA). Overexpression of a disintegrin and metalloproteinase 17 (ADAM 17) and connective tissue growth factor (CTGF) leads to development of tissue fibrosis. However, the signaling pathway in hypoxia-induced ADAM 17 expression remains poorly defined. In this study, we investigated the roles that ribosomal S-6 kinase 1 (RSK1)/CCAAT/enhancer-binding protein β (C/EBPβ)-dependent ADAM 17 expression plays in hypoxia-induced CTGF expression in human lung fibroblasts...
June 21, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28646674/a-multimodal-spatiotemporal-cardiac-motion-atlas-from-mr-and-ultrasound-data
#12
Esther Puyol-Antón, Matthew Sinclair, Bernhard Gerber, Mihaela Silvia Amzulescu, Hélène Langet, Mathieu De Craene, Paul Aljabar, Paolo Piro, Andrew P King
Cardiac motion atlases provide a space of reference in which the motions of a cohort of subjects can be directly compared. Motion atlases can be used to learn descriptors that are linked to different pathologies and which can subsequently be used for diagnosis. To date, all such atlases have been formed and applied using data from the same modality. In this work we propose a framework to build a multimodal cardiac motion atlas from 3D magnetic resonance (MR) and 3D ultrasound (US) data. Such an atlas will benefit from the complementary motion features derived from the two modalities, and furthermore, it could be applied in clinics to detect cardiovascular disease using US data alone...
June 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28646662/estimation-of-the-molar-absorption-coefficient-of-copper-salicylate-within-the-spectral-range-300-350nm
#13
N L Lavrik, N U Mulloev
Additional absorption was detected in absorption spectra within the range 300-350nm after addition of copper sulfate CuSO4(aq) to a solution of sodium salicylate NaНSal (рН=7.8). The additional maximum absorption was observed at 320nm. Assuming that the additional absorption depends on the formation of copper salicylate CuSal, the molar absorption coefficient εCuSal of this complex was determined to be (3.8±0.02)·10(3)М(-1)сm(-1). This value is almost equal to that of monoanion HSal(-), εHSal-=(3.6±0...
June 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28646660/towards-understanding-transcriptional-networks-in-cellular-reprogramming
#14
REVIEW
Jaber Firas, Jose M Polo
Most of the knowledge we have on the molecular mechanisms of transcription factor mediated reprogramming comes from studies conducted in induced pluripotency. Recently however, a few studies investigated the mechanisms of cellular reprogramming in direct and indirect transdifferentiation, which allows us to explore whether shared parallel mechanisms can be drawn. Moreover, there are currently several computational tools that have been developed to predict and enhance the reprogramming process by reconstructing the transcriptional networks of reprogramming cells...
June 21, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28646653/cryo-em-beyond-the-microscope
#15
REVIEW
Lesley A Earl, Veronica Falconieri, Jacqueline Ls Milne, Sriram Subramaniam
The pace at which cryo-EM is being adopted as a mainstream tool in structural biology has continued unabated over the past year. Initial successes in obtaining near-atomic resolution structures with cryo-EM were enabled to a large extent by advances in microscope and detector technology. Here, we review some of the complementary technical improvements that are helping sustain the cryo-EM revolution. We highlight advances in image processing that permit high resolution structure determination even in the presence of structural and conformational heterogeneity...
June 21, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28646650/requirement-for-eukaryotic-translation-initiation-factors-in-cap-independent-translation-differs-between-bipartite-genomic-rnas-of-red-clover-necrotic-mosaic-virus
#16
Yuri Tajima, Hiro-Oki Iwakawa, Kiwamu Hyodo, Masanori Kaido, Kazuyuki Mise, Tetsuro Okuno
The bipartite genomic RNAs of red clover necrotic mosaic virus (RCNMV) lack a 5' cap and a 3' poly(A) tail. RNA1 encodes viral replication proteins, and RNA2 encodes a movement protein (MP). These proteins are translated in a cap-independent manner. We previously identified two cis-acting RNA elements that cooperatively recruit eukaryotic translation initiation factor (eIF) complex eIF4F or eIFiso4F to RNA1. Such cis-acting RNA elements and host factors have not been identified in RNA2. Here we found that translation of RNA1 was significantly compromised in Arabidopsis thaliana carrying eif4f mutation...
June 21, 2017: Virology
https://www.readbyqxmd.com/read/28646644/a-systematic-review-to-uncover-a-universal-protocol-for-accuracy-assessment-of-3-dimensional-virtually-planned-orthognathic-surgery
#17
REVIEW
Ramy M Gaber, Eman Shaheen, Bart Falter, Sebastian Araya, Constantinus Politis, Gwen R J Swennen, Reinhilde Jacobs
PURPOSE: The aim of this study was to systematically review methods used for assessing the accuracy of 3-dimensional virtually planned orthognathic surgery in an attempt to reach an objective assessment protocol that could be universally used. MATERIALS AND METHODS: A systematic review of the currently available literature, published until December 9, 2016, was conducted using PubMed as the primary search engine. We performed secondary searches using the Cochrane Database, clinical trial registries, Google Scholar, and Embase, as well as a bibliography search...
June 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28646627/collecting-validity-evidence-for-simulation-based-assessment-of-point-of-care-ultrasound-skills
#18
Jesper Kørup Jensen, Liv Dyre, Mattis Enggaard Jørgensen, Lisbeth Anita Andreasen, Martin Grønnebaek Tolsgaard
OBJECTIVES: The aim of this study was to examine the validity of a simulator test designed to evaluate focused assessment with sonography for trauma (FAST) skills. METHODS: Participants included a group of ultrasound novices (n = 25) and ultrasound experts (n = 10). All participants had their FAST skills assessed using a virtual reality ultrasound simulator. Procedural performance on the 4 FAST windows was assessed by automated simulator metrics, which received a passing or failing score...
June 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28646619/early-insights-into-zika-s-microcephaly-physiopathology-from-the-epicentre-of-the-outbreak-teratogenic-apoptosis-on-the-central-nervous-system
#19
Patricia Jungmann, Pedro Pires, Edward Araujo
Foetal infection by the Zika virus has been implicated in the exceptional rise in the number of mycrocephalic newborns recorded by the end of 2015 in Brazil. The mechanism by which this teratogenic effect is produced in the developing brain has not been entirely established. Very early in the outbreak, we addressed this question by evaluating available initial data from a gestational and post-natal clinical investigation in the Brazilian state of Pernambuco. The present study was undertaken to test the hypothesis that the subtractive dysmorphic brain malformations observed in Zika's microcephaly are primarily due to the massive induction of apoptosis of neuroprogenitor cells...
June 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28646587/perioperative-pain-management-after-fibular-free-flap-harvesting-for-head-and-neck-reconstruction-using-mini-catheters-to-inject-local-anesthetic-a-pilot-study
#20
Andrea Ferri, Andrea Varazzani, Adriana Valente, Giuseppe Pedrazzi, Bernardo Bianchi, Silvano Ferrari, Enrico Sesenna
BACKGROUND: Fibular donor site pain management in the early postoperative period can help minimize complications, patient discomfort, and agitation. Traditional management of postoperative pain consists of systemic administration of opioids and NSAIDS. The use of local anesthetics in addition to systemic analgesics has the potential to improve pain control. Purpose of the study is to evaluate the efficacy of mini-catheters used to inject local anesthetic into the fibular donor site after flap harvesting for reconstruction of the head-and-neck area...
June 24, 2017: Microsurgery
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