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Nilesh Barwar, Param Jit Singh, Tarun Goyal, Pankaj Kumar Sharma, Sanjay Jain, Lakshman Das
Child abuse is a matter of serious concern that can often result in devastating injuries. Incidence of spinal injuries from child abuse has been reported in <1-3 % of spinal injury cases. In the present study, a case of thoracolumbar translational injury (AO type C) is presented following an incidence of child abuse in a 2-year-old female. After successful management with operative fixation, the child showed a remarkable recovery in her neurological function with ambulatory power.
June 2024: Trauma Case Reports
#22
Amine El Farhaoui, Mohamed Maroc, Zakaria Khatab, Anass Sefti, Mbainaidara Debonheur, Adnane Lachkar, Najib Abdeljaouad, Hicham Yacoubi
Subtalar dislocation is characterized by simultaneous dislocation of the subtalar (talocalcaneal) and talonavicular joints, hence the name talocalcaneonavicular. These lesions can be grouped into four distinct categories: anterior and posterior, which are exceptional, lateral and medial. Medial subtalar dislocations are more frequent, are due to low-energy trauma and generally have good functional results. Anatomical reduction and stabilization of the subtalar joint and optimal management of all associated foot injuries are the key to good results...
June 2024: Trauma Case Reports
#23
JOURNAL ARTICLE
Ary Marchellina, Agoes Soegianto, Trisnadi Widyaleksono Catur Putranto, Wildanun Mukholladun, Carolyn Melissa Payus, Yulia Irnidayanti
The massive industrial growth in Gresik, East Java, Indonesia has the potential to result in metal contamination in the nearby coastal waters. The purpose of this study was to analyze the metal concentrations in edible species from the Gresik coastal waters and evaluate the potential health risks linked to this metal contamination. Metal concentrations (Cu, Fe, Pb, Zn, As, Cd, Ni, Hg, and Cr) in fish and shrimp samples mostly met the maximum limits established by national and international regulatory organizations...
April 14, 2024: Marine Pollution Bulletin
#24
REVIEW
Muhamad Yudatama Perdana, Bashir Ahmed Johan, Muaz Abdallah, Md Emdad Hossain, Md Abdul Aziz, Turki Nabieh Baroud, Qasem Ahmed Drmosh
Energy harvesting and energy storage are two critical aspects of supporting the energy transition and sustainability. Many studies have been conducted to achieve excellent performance devices for these two purposes. As energy-storing devices, supercapacitors (SCs) have tremendous potential to be applied in several sectors. Some electrochemical characterizations define the performance of SCs. Electrochemical impedance spectroscopy (EIS) is one of the most powerful analyses to determine the performance of SCs...
April 15, 2024: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
#25
JOURNAL ARTICLE
Eimear K Ryan, Christy Clutter, Conor De Barra, Benjamin J Jenkins, Simon O'Shaughnessy, Odhrán K Ryan, Chloe McKenna, Helen M Heneghan, Fiona Walsh, David K Finlay, Linda V Sinclair, Nicholas Jones, Daniel T Leung, Donal O'Shea, Andrew E Hogan
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production. The metabolic and nutritional requirements for optimal MAIT cell effector responses are still emerging. Iron is an important micronutrient and is essential for cellular fitness, in particular cellular metabolism...
April 15, 2024: Journal of Immunology
#26
JOURNAL ARTICLE
Michael K Wong, Cassian Yee
Merkel cell carcinoma (MCC) is an aggressive, fast-growing, highly metastatic neuroendocrine skin cancer. The Merkel cell polyomavirus (MCPyV) is an oncogenic driver in the majority of MCC tumors. In this issue of the JCI, Hansen and authors report on their tracking of CD8+ T cells reactive to MCPyV T antigen (T-Ag) in the peripheral blood of 26 patients with MCC who were undergoing frontline anti-programmed cell death protein-1 (anti-PD-1) immunotherapy. They discovered unique T cell epitopes and used the power of bar-coded tetramers to portray immune checkpoint inhibitor-induced immunogenicity as a predictor of clinical response...
April 15, 2024: Journal of Clinical Investigation
#27
JOURNAL ARTICLE
Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W Zimmerman, Thomas Eder, Diaaeldin I Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Daniel Pölöske, Emina Hubanic, Dennis Jungherz, Tony Andreas Müller, Myint Myat Khine Aung, Anna Orlova, Ha Thi Thanh Pham, Kerstin Zimmel, Thomas Krausgruber, Christoph Bock, Mathias Müller, Maik Dahlhoff, Auke Boersma, Thomas Rülicke, Roman Fleck, Elvin Dominic de Araujo, Patrick Thomas Gunning, Tero Aittokallio, Satu Mustjoki, Takaomi Sanda, Sylvia Hartmann, Florian Grebien, Gregor Hoermann, Torsten Haferlach, Philipp Bernhard Staber, Heidi Anne Neubauer, Alfred Thomas Look, Marco Herling, Richard Moriggl
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent and clinically challenging STAT5BN642H driver in T cell development and immature T cell cancer onset and compared it with STAT5A hyperactive variants in transgenic mice. Enhanced STAT5 activity caused disrupted T cell development and promoted an early T cell progenitor-ALL phenotype, with upregulation of genes involved in T cell receptor (TCR) signaling, even in absence of surface TCR...
April 15, 2024: Journal of Clinical Investigation
#28
Filippo Randelli, Lorenzo Banci, Ornella Visentin, Danilo Di Via, Alberto Fioruzzi
Removal of a retained and osseointegrated intramedullary femoral nail can represent a considerable problem, especially in the case of contemporary total hip arthroplasty or, even worse, in the case of revision hip arthroplasty. Usually, complex and invasive surgical techniques are required to remove incarcerated Kuntscher nails. We described a case of an incarcerated Kuntscher nail, inserted 39 years before, in a 75-year-old woman waiting for a revision total hip arthroplasty of a failed metal-on-metal hip resurfacing...
June 2024: Trauma Case Reports
#29
Yogesh Sharad Salphale, Aman Tomar, Vikrant G Salphale, Atharva R Sharma, Gopal Shinde
Diaphyseal forearm fractures are typically treated with open reduction and plate fixation, which has been proven to be the most effective method in numerous trials. However, the risk of periosteal stripping, haemorrhage evacuation, nonunion, and infection is always present and may cause a delayed union and other surgical consequences. Although intramedullary nails have been mentioned in the literature for forearm bone fractures, issues regarding their common complication of nail migration, especially of the ulnar fracture, before the fracture has been consolidated is an issue, and has not been addressed...
June 2024: Trauma Case Reports
#30
Luis Fernandez, Reginald Carl Baptiste, Rebekah Bjorklund, Ala'a Alkhatib, Nesiya Sheriff, Claudia Sanchez, Mary Anne Obst, Rebecca Swindall
Severe subcutaneous emphysema (SSE) is the presence of a high-volume accumulation of air in the subcutaneous tissue caused by traumatic injuries, infections, iatrogenic causes, or can also manifest spontaneously. A variety of techniques have been reported, with varying levels of success. We present a multicenter case series detailing four patients who developed SSE and were treated with Incisional Negative Pressure Wound Therapy (INPWT). All patients significantly improved with the INPWT treatment within 6 to 48 h...
June 2024: Trauma Case Reports
#31
JOURNAL ARTICLE
Ryo Wakita, Yukiko BaBa, Haruhisa Fukayama, Shigeru Maeda
BACKGROUND/PURPOSE: The possibility of triggering the trigeminocardiac reflex (TCR) during oral surgery is considerably lower than that during other surgeries. A reduced heart rate (HR) of ≥20% from baseline is usually considered a diagnostical criterion for the TCR. Our automated anesthesia charting system often revealed cases of slight transient HR decrease during sedation. We aimed to explore its incidence and associated factors during local anesthesia administration under intravenous sedation...
April 2024: Journal of Dental Sciences
#32
JOURNAL ARTICLE
Junheng Guo, Yuyao Wang, Jingyu Hou, Tingshuo Zhao, Zhigang Wei
BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a common and deadly tumor. Currently, there is a severe lack of therapeutic options. As a novel mode of cell death, increasing evidence reveals the important role of the disulfidptosis in cancer. However, few studies have utilized disulfidptosis-related long-stranded non-coding RNAs (DRlncRNAs) to investigate the prognosis of PAAD. METHODS: We comprehensively analyzed the expression and prognostic value of 958 DRlncRNAs in PAAD using data from The Cancer Genome Atlas (TCGA)...
March 31, 2024: Translational Cancer Research
#33
JOURNAL ARTICLE
Le Wang, Yulin Zhang, Hongmin Li, Jilin Peng, Changhui Gao, Qiuning Yu, Pei Gao, Ling Li, Kuisheng Chen, Fanglei Ye
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the most common type and accounts for 90% of all head and neck cancer cases. Despite advances in early diagnosis and treatment strategies-chemotherapy, surgical resection, and radiotherapy-5-year survival remains grim. For patients with early-stage HNSCC, accurately predicting clinical outcomes is challenging. Considering the pivotal role of the immune system in HNSCC, we developed a reliable immune-related gene signature (IRGS) and explored its predictive accuracy in patients with early-stage HNSCC...
March 31, 2024: Translational Cancer Research
#34
JOURNAL ARTICLE
Segmentation method of magnetic resonance imaging brain tumor images based on improved UNet network.
Yang Yang, Peng Wang, Zhenyu Yang, Yuecheng Zeng, Feng Chen, Zhiyong Wang, Stefania Rizzo
BACKGROUND: Glioma is a primary malignant craniocerebral tumor commonly found in the central nervous system. According to research, preoperative diagnosis of glioma and a full understanding of its imaging features are very significant. Still, the traditional segmentation methods of image dispensation and machine wisdom are not acceptable in glioma segmentation. This analysis explores the potential of magnetic resonance imaging (MRI) brain tumor images as an effective segmentation method of glioma...
March 31, 2024: Translational Cancer Research
#35
JOURNAL ARTICLE
Zujun Ding, Qing Ding, Hang Li
BACKGROUND: Tubulin polyglutamylase complex subunit 2 (TPGS2) is an element of the neuronal polyglutamylase complex that plays a role in the post-translational addition of glutamate residues to C-terminal tubulin tails. Recent research has shown that TPGS2 is associated with some tumors, but the roles of TPGS2 in tumor immunity remain unclear. METHODS: The research data were mainly sourced from The Cancer Genome Atlas. The data were analyzed to identify potential correlations between TPGS2 expression and survival, gene alterations, the tumor mutational burden (TMB), microsatellite instability (MSI), immune infiltration, and various immune-related genes across various cancers...
March 31, 2024: Translational Cancer Research
#36
JOURNAL ARTICLE
Suryanarayana Reddy Challa, Gholamreza Oskrochi, Gagan Paul Singh, Lakshmi G Chirumamilla, Nader Shayegh, Vaisakh K Nair, Megan Littleton, Danae T Byer, Nicole A Morrison, Brittany L Grossi, Barclay Ashanna, Shahnoza Dusmatova, Trae Thompson, Dideolu O Dawodu, Hassan Brim, Hassan Ashktorab
BACKGROUND: Coronavirus disease 2019 (COVID-19) manifest differently depending on patients' background and pre-existing conditions. It remains unclear how African Americans with cancer have been affected in comparison to those without. In this study, we aim to identify demographic, clinical, and laboratory markers associated with mortality in COVID-19 patients with cancer. METHODS: We reviewed all COVID-19 hospitalized patients' records from Dec. 2019 to Oct. 2021 at Howard University Hospital...
March 31, 2024: Translational Cancer Research
#37
REVIEW
Ying Jin, Haiyi Wu, Jianzhao Liu, William C Cho, Guoqi Song
BACKGROUND AND OBJECTIVE: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) gene editing and CRISPR/Cas9 screening libraries are hot topics, and have high application values in the diagnosis and treatment of genetic diseases, and the improvement of prognosis. The major treatment of B-cell lymphoma is chemotherapy combined with biological therapy. Due to the individual specificity and the emergence of drug resistance, the therapeutic efficacy varies...
March 31, 2024: Translational Cancer Research
#38
JOURNAL ARTICLE
Erna Jia, Xianquan Shi, Jinru Xue
BACKGROUND: CCND2 expression influences the growth and proliferation of cancer cells and plays a crucial role in immune response of tumor. However, few studies focused on the correlation between CCND2 and lung adenocarcinoma (LUAD) in terms of prognosis and tumor immune infiltration. METHODS: Original LUAD case data were screened from The Cancer Genome Atlas (TCGA) database. Using R software, we analyzed differently expressed CCND2 between LUAD and adjacent normal tissues...
March 31, 2024: Translational Cancer Research
#39
JOURNAL ARTICLE
Peng Zhang, Jingjing Yang, Xiaolong Zhong, Heloisa Sobreiro Selistre-de-Araujo, Stergios Boussios, Yongneng Ma, Hua Fang
BACKGROUND: Breast cancer (BC/BRCA) is the most common carcinoma in women. The average 5-year survival rate of BC patients with stage IV disease is 26%. A considerable proportion of patients still do not receive effective therapy. It is an unmet need to identify novel biomarkers for BC patients. Herein, we evaluated whether the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) status is associated with the clinical outcomes of BC, based on data from The Cancer Genome Atlas (TCGA)...
March 31, 2024: Translational Cancer Research
#40
JOURNAL ARTICLE
Yuan Zhou, Borong Huang, Qinqin Zhang, Yaqun Yu, Juan Xiao
BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a lethal disease with a poor prognosis. Genes involved in acute pancreatitis (AP) or chronic pancreatitis (CP) might be important for PAAD development. This study sought to identify potential PAAD diagnosis markers and to establish a PAAD prognosis prediction model based on AP- and CP-related genes. METHODS: The significantly differentially expressed genes in both AP or CP and PAAD were obtained by a bioinformatics analysis...
March 31, 2024: Translational Cancer Research
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