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https://www.readbyqxmd.com/read/28944952/bypassing-agent-prophylaxis-in-people-with-hemophilia-a-or-b-with-inhibitors
#1
REVIEW
Chatree Chai-Adisaksopha, Sarah J Nevitt, Mindy L Simpson, Maissaa Janbain, Barbara A Konkle
BACKGROUND: People with hemophilia A or B with inhibitors are at high risk of bleeding complications. Infusion of bypassing agents, such as recombinant activated FVII (rFVIIa) and plasma-derived activated prothrombin complex concentrate, are suggested as alternative therapies to factor VIII (haemophilia A) or IX (haemophilia B) for individuals who no longer respond to these treatments because they develop inhibitory antibodies. The ultimate goal of treatment is to preserve the individual's joints, otherwise destroyed by recurrent bleeds...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944908/hypermethylation-of-wif1-and-its-inhibitory-role-in-the-tumor-growth-of-endometrial-adenocarcinoma
#2
Xinchao Deng, Congzhe Hou, Huali Wang, Tingting Liang, Lin Zhu
Endometrial carcinoma is the most common malignancy of the female genital tract and is the fourth most common malignancy among women worldwide. Endometrial adenocarcinoma (EAC) accounts for ~80% of endometrial carcinoma cases. Numerous critical genetic events have been determined to serve an essential role in EAC progression; however, the precise molecular mechanisms underlying EAC progression remain unclear. Pyrosequencing and methylation‑specific PCR were used to detect the methylation status of Wnt inhibitory factor 1 (WIF1)...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944904/triptolide-inhibits-proliferation-differentiation-and-induces-apoptosis-of-osteoblastic-mc3t3%C3%A2-e1-cells
#3
Wei Ji, Shijia Liu, Xia Zhao, Yunke Guo, Sha Xia, Yueyang Lu, Menyun Yin, Xiao Xu
Ankylosing spondylitis (AS) is characterized by the formation of bony spurs. Treatment of the resulting ankylosis, excessive bone formation and associated functional impairment, remain the primary therapeutic aims in research regarding this condition. Triptolide is the primary active component of the perennial vine Tripterygium wilfordii Hook. f., and has previously been demonstrated to exert anti‑tumor activities including inhibition of cell growth and the induction of apoptosis, however, the effect of triptolide on osteoblasts remains to be elucidated...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944893/pigment-epithelium%C3%A2-derived-factor-protects-human-glomerular-mesangial-cells-from-diabetes-via-noxo1%C3%A2-inos-suppression
#4
Ling Gao, Yingjie Hu, Jing Li
The authors previously reported that pigment epithelium‑derived factor (PEDF) protects the diabetic kidney from fibrosis via its anti‑oxidative effects. However, the underlying molecular mechanism has never been revealed. The present study aimed to investigate how PEDF protects mesangial cells from diabetes induced damage. Human mesangial cells were exposed to a diabetic environment [30 mmol/l glucose and 200 mg advanced glycation end products (AGEs)] in the absence or presence of PEDF (200 mg/l). The superoxide and peroxynitrite productions were measured by fluorescent assay...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944890/paeonol-exerts-potential-activities-to-inhibit-the-growth-migration-and-invasion-of-human-gastric-cancer-bgc823-cells-via-downregulating-mmp%C3%A2-2-and-mmp%C3%A2-9
#5
Zhong-Kuan Lyu, Chang-Ling Li, Yan Jin, Yu-Zhao Liu, Xi Zhang, Fang Zhang, Lu-Ning Ning, Er-Shun Liang, Min Ma, Wei Gao, Ming-Xiang Zhang, De-Shan Liu
Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investigate the under‑reported effects of Pae on the growth, invasion and migration of poorly differentiated BGC823 gastric cancer cells with strong invasive and metastatic abilities...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944853/kisspeptin-inhibits-cancer-growth-and-metastasis-via-activation-of-eif2ak2
#6
Tae-Hun Kim, Sung-Gook Cho
Kisspeptin is a protein encoded by the KISS1 gene, which has been reported to suppress the metastatic capabilities of various types of cancer cells, through the activation of its G‑protein coupled receptor GPR54. However, the molecular mechanisms underlying the involvement of kisspeptin‑mediated signaling in the inhibition of cancer cell migration and invasion have yet to be elucidated. The present in vitro cell proliferation, migration and invasion assays and in vivo experimental metastasis studies demonstrated that kisspeptin‑induced eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) activation suppressed the metastatic capabilities of several types of cancer cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944845/efficient-inhibition-of-duck-hepatitis-b-virus-dna-by-the-crispr-cas9-system
#7
Qingfen Zheng, Li Bai, Sujun Zheng, Mei Liu, Jinyan Zhang, Ting Wang, Zhongwei Xu, Yu Chen, Jiansheng Li, Zhongping Duan
Current therapeutic strategies cannot eradicate hepatitis B virus covalently closed circular DNA (HBV cccDNA), which accounts for the persistence of HBV infection. Very recently, the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‑associated protein 9 (Cas9) system has been used as an efficient and powerful tool for viral genome editing. Given that the primary duck hepatocyte (PDH) infected with duck hepatitis B virus (DHBV) has been widely used to study human HBV infection in vitro, the present study aimed to demonstrate the targeted inhibition of DHBV DNA, especially cccDNA, by the CRISPR/Cas9 system using this model...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944833/low-doses-of-co-nanoparticles-induce-death-and-regulate-osteogenic-differentiation-in-mg%C3%A2-63-cells
#8
Qinglin Han, Fan Liu
The aim of the present study was to investigate the effects of cobalt nanoparticles (CoNPs) on the proliferation and differentiation of human osteoblasts in vitro, and to investigate the molecular mechanisms via which CoNPs affect proliferation and differentiation of osteoblasts. The MG‑63 human osteoblast cell line was treated with different concentrations of CoNPs for 12 to 48 h in vitro. At each time point, cell morphology was observed and an MTT assay was performed to assess cell viability. Alkaline phosphatase (ALP), osteocalcin (BGLAP), collagen I (COL I), osteoprotegerin (OPG) and receptor activator of nuclear factor κ‑B ligand mRNA expression levels, and ALP, BGLAP and COL protein expression levels, were assessed by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944806/egg-derived-bioactive-peptides-with-ace-inhibitory-properties-a-literature-update
#9
REVIEW
Charlotte Grootaert, Bea Matthijs, Stefan Voorspoels, Sam Possemiers, Guy Smagghe, John Van Camp
Egg proteins contain a wide set of peptide sequences which have an impact on cardiovascular health. Their modes-of-action involve, among others, the inhibition of angiotensin-converting enzyme (ACE) and antioxidant and anti-inflammatory properties. In this review, we focus particularly on ACE-inhibition and discuss recent findings in: (i) production methods for egg protein-derived ACE-inhibitory peptides, (ii) in vitro functionality of these peptides, (iii) their intestinal digestion and absorption in order to reach the target tissue, (iv) the impact of ACE-inhibitory egg-derived peptides in vivo and (v) future perspectives for the implementation of egg-derived ACE-inhibitory peptides as functional foods...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944737/alginate-gelatin-formulation-to-modify-lovastatin-release-profile-from-red-yeast-rice-for-hypercholesterolemia-therapy
#10
Gemma Leone, Marco Consumi, Simone Pepi, Stefania Lamponi, Claudia Bonechi, Gabriella Tamasi, Alessandro Donati, Claudio Rossi, Agnese Magnani
AIM: The preparation of a delivery system able to guarantee a delayed release of lovastatin from red yeast rice (RYR) is mandatory to counteract cholesterol biosynthesis effectively. MATERIALS & METHODS: Polymeric formulations were prepared mixing alginate and gelatin, in different ratios, with RYR. The effect of different composition on stiffness, viscosity, swelling behavior and mesostructure of matrices was analyzed. RESULTS: Formulations obtained combining polymers in comparable amount (i...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944698/diterpenoids-from-the-roots-of-euphorbia-fischeriana-and-their-inhibitory-effects-on-%C3%AE-glucosidase
#11
Yun-Long Wei, Zhen-Long Yu, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Shan-Shan Huang, Sa Deng, Xiao-Chi Ma, Jing-Ming Jia, Chao Wang
Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculated ECD, which gave two new diterpenoids, daphnane type (1) and ent-pimarene type (3). Additionally, the isolated compounds (1-3) displayed moderate inhibitory effects against α-glucosidase in an in vitro bioassay...
September 25, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28944681/chemical-characteristics-of-the-fungus-ganoderma-lucidum-and-their-inhibitory-effects-on-acetylcholinesterase
#12
Jiang-Chun Wei, An-Hua Wang, Yun-Long Wei, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Xiao-Chi Ma, Chao Wang, Shan-Shan Huang, Jing-Ming Jia
The chemical characteristic of a well-known folk medicine Ganoderma lucidum has been investigated by a series of chromatographic technologies, which displayed the presences of 45 lanostane type triterpenoids, including two new nor-lanostane triterpenoids (40, 41). Their structures were identified on the basis of spectroscopic data analysis (UV, IR, HRESIMS, 1D, and 2D NMR). Notably, some triterpenoids displayed moderate inhibitory effects against AChE (acetylcholinesterase) by an in vitro screened experiment...
September 25, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28944669/total-synthesis-of-kanamienamide
#13
Devi Prabhakar Reddy, Ning Zhang, Zhimei Yu, Zhen Wang, Yun He
Kanamienamide is a novel enol ether containing enamide with single digit micromolar inhibitory activity against cancer cell lines. An efficient and convergent total synthesis of kanamienamide has been developed for the first time, which features a Cu-mediated amide coupling with vinyl iodide at the late stage. Other key transformations include Evans asymmetric alkylation, CBS asymmetric reduction, ring-closing metathesis reaction and Stork-Zhao-Wittig olefination. This strategy is amenable for facile analogue preparation and SAR studies...
September 25, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28944661/tempo-conjugated-gold-nanoparticles-for-reactive-oxygen-species-scavenging-and-regulation-of-stem-cell-differentiation
#14
Jingchao Li, Jing Zhang, Ying Chen, Naoki Kawazoe, Guoping Chen
Controlling the differentiation of human mesenchymal stem cells (hMSCs) shows a great potential in regenerative medicine. Because overproduced reactive oxygen species (ROS) have obvious inhibitory effect on the differentiation and functions of hMSCs, it is highly desirable to develop effective strategy for ROS scavenging and stem cell differentiation controlling. In this study, gold nanoparticles (Au NPs) with an average size of 40 nm were conjugated with 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to endow them with ROS scavenging capacity while holding the beneficial effect of Au NPs...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944614/developmental-associations-between-bilingual-experience-and-inhibitory-control-trajectories-in-head-start-children
#15
Jimena Santillán, Atika Khurana
Children from lower socioeconomic (SES) backgrounds tend to be at-risk for executive function (EF) impairments by the time they are in preschool, placing them at an early disadvantage for academic success. The present study examined the potentially protective role of bilingual experience on the development of inhibitory control (IC) in 1146 Head Start preschoolers who were followed for an 18-month period during the transition to kindergarten as part of the longitudinal Family and Child Experiences Survey (FACES) 2009 study...
September 24, 2017: Developmental Science
https://www.readbyqxmd.com/read/28944565/novel-tetrahydroacridine-derivatives-with-iodobenzoic-acid-moiety-as-multifunctional-acetylcholinesterase-inhibitors
#16
Robert Skibiński, Kamila Czarnecka, Małgorzata Girek, Ireneusz Bilichowski, Nina Chufarova, Elżbieta Mikiciuk-Olasik, Paweł Szymański
New synthesized series of 9-amino-1,2,3,4-tetrahydroacridine derivatives with iodobenzoic acid moiety were studied for their inhibitory activity towards cholinesterase and against β-amyloid aggregation. All novel molecules 3a-3i interacted with both cholinesterases - acetylcholinesterase and butyrylcholinesterase, delivered nanomolar IC50 values. The structure-activity relationship showed that N-butyl moiety derivatives are stronger inhibitors towards AChE and BuChE than N-ethyl and N-propyl moieties compounds...
September 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28944454/an-inhibitory-epitope-of-human-toll-like-receptor-4-resides-on-leucine-rich-repeat-13-and-is-recognized-by-a-monoclonal-antibody
#17
Hiroki Tsukamoto, Yuki Yamagata, Ippo Ukai, Shino Takeuchi, Misaki Okubo, Yohei Kobayashi, Sao Kozakai, Kanae Kubota, Muneo Numasaki, Yoshitomi Kanemitsu, Yotaro Matsumoto, Yoshihisa Tomioka
No abstract text is available yet for this article.
September 2017: FEBS Letters
https://www.readbyqxmd.com/read/28944167/regulation-of-cytotoxic-t-cell-responses-by-p53-in-cancer
#18
Mitchell W Braun, Tomoo Iwakuma
An intriguing aspect of the tumor suppressor p53 is its ability to communicate to the adaptive immune system and control the cytotoxic T-lymphocyte (CTL) response to cancer cells. Wild-type p53 (wtp53) communicates with CTLs through proteins involved in the major histocompatibility complex (MHC) class I antigen presentation pathway [e.g., transporter associated with antigen processing 1 (TAP1) and endoplasmic reticulum amino peptidase 1 (ERAP1)], the apoptosis signal receptor Fas/APO-1, and the inhibitory immune-checkpoint programmed death-ligand 1 (PD-L1)...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28943958/value-of-the-level-of-methylation-of-rassf1a-and-wif-1-in-tissue-and-serum-in-neoadjuvant-chemotherapeutic-assessment-for-advanced-breast-cancer
#19
Zhong-Hua Han, Chun-Sen Xu, Hui Han, Chuan Wang, Shun-Guo Lin
This study assessed the clinical efficacy of the neoadjuvant chemotherapy TAC scheme in treatment of patients with locally advanced breast cancer, and the value of the level of Ras association domain family 1A (RASSF1A) gene methylation and the Wnt inhibitory factor (WIF)-1 gene in tissue and serum of patients in clinical outcome prediction. In total, 126 patients were consecutively selected to receive TAC scheme (docetaxel, pirarubicin/epirubicin and cyclophosphamide) for at least four cycles with the total effective rate...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943934/l-securinine-inhibits-the-proliferation-of-a549-lung-cancer-cells-and-promotes-dkk1-promoter-methylation
#20
Shuwen Han, Xi Yang, Yuefen Pan, Quan Qi, Junjun Shen, Huifen Fang, Zhaoning Ji
L-securinine is a natural product extracted and isolated from the leaf of dried Securinega suffruticosa. The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and fibroblasts. L-securinine was extracted, isolated and the structure was identified. The cytotoxicity of L-securinine in A549 cells was evaluated by Cell Counting Kit-8 assays. The expression and DNA methylation profile of DKK genes was analyzed by reverse transcription-quantitative polymerase chain reaction and bisulfite sequencing polymerase chain reaction, respectively...
October 2017: Oncology Letters
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