keyword
MENU ▼
Read by QxMD icon Read
search

Exhaustion

keyword
https://www.readbyqxmd.com/read/29036856/informal-care-employment-and-quality-of-life-barriers-and-facilitators-to-combining-informal-care-and-work-participation-for-healthcare-professionals
#1
Eveline Heitink, Yvonne Heerkens, Josephine Engels
BACKGROUND: In The Netherlands, one out of six Dutch employees has informal care tasks; in the hospital and healthcare sector, this ratio is one out of four workers. Informal carers experience problems with the combination of work and informal care. In particular, they have problems with the burden of responsibility, a lack of independence and their health. These problems can reveal themselves in a variety of mental and physical symptoms that can result in absenteeism, reduction or loss of (work) participation, reduction of income, and even social isolation...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036855/diagnostic-criteria-for-persistent-postural-perceptual-dizziness-pppd-consensus-document-of-the-committee-for-the-classification-of-vestibular-disorders-of-the-b%C3%A3-r%C3%A3-ny-society
#2
Jeffrey P Staab, Annegret Eckhardt-Henn, Arata Horii, Rolf Jacob, Michael Strupp, Thomas Brandt, Adolfo Bronstein
This paper presents diagnostic criteria for persistent postural-perceptual dizziness (PPPD) to be included in the International Classification of Vestibular Disorders (ICVD). The term PPPD is new, but the disorder is not. Its diagnostic criteria were derived by expert consensus from an exhaustive review of 30 years of research on phobic postural vertigo, space-motion discomfort, visual vertigo, and chronic subjective dizziness. PPPD manifests with one or more symptoms of dizziness, unsteadiness, or non-spinning vertigo that are present on most days for three months or more and are exacerbated by upright posture, active or passive movement, and exposure to moving or complex visual stimuli...
October 7, 2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29036843/aberrant-peak-lactate-response-in-ms
#3
Kathrin Schlüter, Josephina Maier, Stefan Patra, Stefan M Gold, Christoph Heesen, Karl-Heinz Schulz
BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was to determine and compare the peak blood lactate response to exercise and the maximal workload between two groups of MS patients with different illness severity. METHODS: Twenty-five patients with a relapsing-remitting disease course (Group RR) and 41 patients with a secondary- or primary chronic progressive disease course (group CP) performed an exhaustive incremental bicycle ergometry...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036424/frailty-and-healthcare-costs-longitudinal-results-of-a-prospective-cohort-study
#4
André Hajek, Jens-Oliver Bock, Kai-Uwe Saum, Herbert Matschinger, Hermann Brenner, Bernd Holleczek, Walter E Haefeli, Dirk Heider, Hans-Helmut König
Objective: to investigate how frailty and frailty symptoms affect healthcare costs in older age longitudinally. Methods: data were gathered from a prospective cohort study in Saarland, Germany (two waves with 3-year interval, n = 1,636 aged 57-84 years at baseline). Frailty was assessed by the five Fried frailty criteria. Frailty was defined as having at least three criteria, the presence of 1-2 criteria as 'pre-frail'. Healthcare costs were quantified based on self-reported healthcare use in the sectors of inpatient treatment, outpatient treatment, professional nursing care and informal care as well as the provision of pharmaceuticals, medical supplies and dental prostheses...
September 21, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29036194/micromeryx-eiselei-a-new-moschid-species-from-steinheim-am-albuch-germany-and-the-first-comprehensive-description-of-moschid-cranial-material-from-the-miocene-of-central-europe
#5
Manuela Aiglstorfer, Loïc Costeur, Bastien Mennecart, Elmar P J Heizmann
Moschids are enigmatic pecoran ruminants whose phylogeny is still not fully understood. So far we know only little of the family's early evolutionary history and the origin of the modern genus, Moschus. Here we present a comprehensive description of cranial material, including the ear region and the dentition, of fossil moschid material from the Middle Miocene locality Steinheim am Albuch (13.5 Ma; Germany). This study provides the first exhaustive dataset for the cranial osteology of Micromeryx flourensianus, the most likely oldest true moschid...
2017: PloS One
https://www.readbyqxmd.com/read/29035687/acute-glutamine-ingestion-modulates-lymphocytic-responses-to-exhaustive-exercise-in-the-heat
#6
Chen Zheng, Xiang-Ke Chen, Yue Zhou
The purpose of this study was to determine if acute intake of glutamine modulates homeostatic, hematologic, immune, and inflammatory responses to exhaustive exercise in the heat. Thirteen healthy untrained young men participated in this randomized, double-blind, placebo-controlled, crossover study. They served as their own control and completed two trials of treadmill exercise at 40% VO2max to exhaustion in a hot environment (38.0 ± 1.0 °C, 60.0 ± 5.0 % relative humidity, and 20.8% oxygen) following placebo (PLA) and glutamine (GLN) consumption...
October 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29035635/effects-of-varying-the-step-duration-on-the-determination-of-lactate-thresholds-in-elite-rowers
#7
Pitre C Bourdon, Sarah M Woolford, Jonathan D Buckley
This study aimed to identify the minimum increment duration required to accurately assess two distinct lactate thresholds. Twenty-one elite rowers (12 female, 9 males) each performed 8-9 rowing tests comprising: 1) five progressive incremental tests (3, 4, 5, 7 or 10 min steps); and 2) at least three 30-min constant-intensity maximal lactate steady state (MLSS) assessments. Power output (PO) at lactate threshold 1 (LT1) was higher in the 3- and 4-min incremental tests. No other measures were different for LT1...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035607/accuracy-of-w-recovery-kinetics-in-high-performance-cyclists-modelling-intermittent-work-capacity
#8
Jason C Bartram, Dominic Thewlis, David T Martin, Kevin I Norton
PURPOSE: With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τW') may require refinement to enable effective use in an elite population. METHODS: Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035587/computer-aided-stroke-by-stroke-visualization-of-actual-and-target-power-allows-for-continuously-increasing-ramp-tests-on-wind-braked-rowing-ergometers
#9
Gunnar Treff, Kay Winkert, Katja Machus, Jürgen M Steinacker
PURPOSE: Ramp tests are continuously increasing exercise tests used for determination of maximal oxygen uptake (⩒O2max), which is identifiable by a plateau in ⩒O2despite increasing mechanical power output (LOAD). On wind-braked rowing ergometers (RowErg) it is hardly feasible to ensure a continuous increase in LOAD until test termination, because neither resistance nor stroke-frequency are externally adjustable, but depend on the rower. To enable ramp tests on rowing ergometers, we produced visual stroke-by-stroke feedback showing target and actual LOAD to the rower...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035580/mutation-sensitivity-maps-identifying-residue-substitutions-that-impact-protein-structure-via-a-rigidity-analysis-in-silico-mutation-approach
#10
Michael Siderius, Filip Jagodzinski
Understanding how an amino acid substitution affects a protein's structure can aid in the design of pharmaceutical drugs that aim at countering diseases caused by protein mutants. Unfortunately, performing even a few amino acid substitutions in vitro is both time and cost prohibitive, whereas an exhaustive analysis that involves systematically mutating all amino acids in the physical protein is infeasible. Computational methods have been developed to predict the effects of mutations, but even many of them are computationally intensive or are else dependent on homology or experimental data that may not be available for the protein being studied...
October 16, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29034666/-respiratory-cancers-attributable-to-occupational-exposures-what-is-the-cost-to-society-in-france
#11
Hassan Serrier, Hélène Sultan-Taïeb, Danièle Luce, Sophie Béjean
OBJECTIVE: To estimate the social cost of respiratory cancers attributable to occupational risk factors in France in 2010. METHODS: We estimated the number of cases of respiratory cancers attributable to each identified occupational risk factor according to the attributable fractions method. We also estimated direct (costs of hospital stays, drugs, outpatient care) and indirect costs (production losses) related to morbidity (absenteeism and presenteeism) and mortality (years of lost production)...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29033936/coinhibitory-receptor-expression-and-immune-checkpoint-blockade-maintaining-a-balance-in-cd8-t-cell-responses-to-chronic-viral-infections-and-cancer
#12
REVIEW
Isobel S Okoye, Michael Houghton, Lorne Tyrrell, Khaled Barakat, Shokrollah Elahi
In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called "immune checkpoints" by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immunopathology, their sustained expression deteriorates T cell function: a phenomenon called exhaustion. Recent advances in cancer immunotherapy involve blockade of cytotoxic T lymphocyte antigen-4 and programmed cell death 1 in order to reverse T cell exhaustion and reinvigorate immunity, which has translated to dramatic clinical remission in many cases of metastatic melanoma and lung cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033885/emotions-and-steroid-secretion-in-aging-men-a-multi-study-report
#13
Andreas Walther, Patricia Waldvogel, Emilou Noser, Jessica Ruppen, Ulrike Ehlert
Although aging increases the risk of cognitive and socioemotional deterioration, it has also been shown to be accompanied by an increase in experienced positive emotions and a decrease in negative emotions. Steroid hormones and age-related alterations in secretion patterns have been suggested to play a crucial role in these age-related changes in emotional experience. Importantly, previous studies identified effects of neuroactive hormones on age-related alterations in emotional experience, which vary by sex and depression levels...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29033862/the-impact-of-bodily-states-on-divergent-thinking-evidence-for-a-control-depletion-account
#14
Yanyun Zhou, Yifei Zhang, Bernhard Hommel, Hao Zhang
Given previous evidence that bodily states can impact basic cognitive processes, we asked whether such impact can also be demonstrated for creative cognition. In particular, we had participants perform a design improvement task and a consequences imagination task while standing up, walking in a predetermined pattern, or walking freely. Results show better divergent-thinking performance with unconstrained than with constrained walking, and better performance for walking than for standing. A second experiment assessed performance in an alternative uses task and a figural combination task while participants were lying, sitting, or standing...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29033354/confronting-the-misbeliefs-pertaining-to-blood-donation-and-transfusion-practices-in-india
#15
A Qureshi
India, a country of 1.3 billion is still yearning for just 12 million units of blood and facing a shortage of 10%; this seemingly small number has claimed many lives, particularly in the less developed parts of the country. The root cause of the problem, although not defined clearly, can be ascertained from the survey reports from different parts of the country targeted to analyze the knowledge, attitude and practices related to blood donation. Most of these reports are coherent in their findings and report the existence of the fallacious perceptions about blood donation even after six decades of the initiation of voluntary blood donation practices...
October 12, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29033173/source-apportionment-for-fine-particulate-matter-in-a-chinese-city-using-an-improved-gas-constrained-method-and-comparison-with-multiple-receptor-models
#16
Guoliang Shi, Jiayuan Liu, Haiting Wang, Yingze Tian, Jie Wen, Xurong Shi, Yinchang Feng, Cesunica E Ivey, Armistead G Russell
PM2.5 is one of the most studied atmospheric pollutants due to its adverse impacts on human health and welfare and the environment. An improved model (the chemical mass balance gas constraint-Iteration: CMBGC-Iteration) is proposed and applied to identify source categories and estimate source contributions of PM2.5. The CMBGC-Iteration model uses the ratio of gases to PM as constraints and considers the uncertainties of source profiles and receptor datasets, which is crucial information for source apportionment...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29033064/mathematical-models-and-vaccination-strategies
#17
Guillaume Béraud
Infection transmission is a complex and dynamic process, and is therefore difficult to assess. Consequently, mathematical models are a useful tool to understand any leverage on this transmission, such as vaccination. Models can provide guidance to implement an optimal vaccination campaign whether it concerns the fraction of the population or the age-group to be vaccinated. Mathematical models can also provide insights on counter-intuitive collateral effects of vaccination campaign, given the possibility that the overall benefits for the general population may hide deleterious effects on some sub-groups...
October 12, 2017: Vaccine
https://www.readbyqxmd.com/read/29032765/recent-patent-advances-for-neurodegenerative-disorders-and-its-treatment
#18
Bhavna Kumar, Deepika Sharma
BACKGROUND: Neurodegenerative disorders are one of the common diseases that affect our society with tremendous medical and financial burdens. As a whole, neurodegeneration affects individuals of all ages, but becomes increasingly frequent with age, coming to affect a very large share of our elderly population which is severely affecting the patient, caregivers, and enormously increasing the financial burden of the nation. These diseases share a very complex nature, which often result from combined genetic, environment and pathogenic factors...
October 10, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29032101/mitochondrial-activity-in-t-cells
#19
REVIEW
Gabriela Desdín-Micó, Gonzalo Soto-Heredero, María Mittelbrunn
Mitochondria fulfill important and diverse roles during the different stages of T cell adaptive responses. Here we discuss the role of the mitochondria in T cells from the initial steps of activation at the immune synapse to their participation in memory responses and T cell exhaustion. Mitochondria are relocated to the immune synapse in order to supply local ATP and to aid calcium signaling. During expansion and proliferation, mitochondrial reactive oxygen species drive proliferation. Aerobic glycolysis, glutaminolysis and fatty acid oxidation regulate the program of differentiation into effector or regulatory T cell subsets, and mitochondrial remodeling proteins are required for the long-lasting phenotype of memory cells...
October 12, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29031786/differentiation-and-protective-capacity-of-virus-specific-cd8-t-cells-suggest-murine-norovirus-persistence-in-an-immune-privileged-enteric-niche
#20
Vesselin T Tomov, Olesya Palko, Chi Wai Lau, Ajinkya Pattekar, Yuhang Sun, Ralitza Tacheva, Bertram Bengsch, Sasikanth Manne, Gabriela L Cosma, Laurence C Eisenlohr, Timothy J Nice, Herbert W Virgin, E John Wherry
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic infection. We found that chronic infection drove MNV-specific tissue-resident memory (Trm) CD8(+) T cells to a differentiation state resembling inflationary effector responses against latent cytomegalovirus with only limited evidence of exhaustion...
October 10, 2017: Immunity
keyword
keyword
19039
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"