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https://www.readbyqxmd.com/read/29232699/cxcr4-blockade-decreases-cd4-t-cell-exhaustion-and-improves-survival-in-a-murine-model-of-polymicrobial-sepsis
#1
Kimberly M Ramonell, Wenxiao Zhang, Annette Hadley, Ching-Wen Chen, Katherine T Fay, John D Lyons, Nathan J Klingensmith, Kevin W McConnell, Craig M Coopersmith, Mandy L Ford
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4 is a chemokine receptor that, following ligation by CXCL12, directs cells to bone marrow niches and also plays an important role in T cell cosignaling and formation of the immunological synapse. Here, we investigated the expression and function of CXCR4 in a murine model of polymicrobial sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29232314/postexercise-fructose-maltodextrin-ingestion-enhances-subsequent-endurance-capacity
#2
Ed Maunder, Tim Podlogar, Gareth A Wallis
PURPOSE: Restoring skeletal muscle and hepatic glycogen content during short-term (<6 h) recovery from prolonged exercise is pertinent for athletes seeking to maximize performance in repeated exercise bouts. Previous research suggests co-ingestion of fructose-glucose carbohydrate sources augments hepatic and has equivalent effects on skeletal muscle glycogen storage during short-term recovery from prolonged exercise compared to isocaloric glucose ingestion. The aim of the present investigation was to determine if this has a discernible effect on subsequent exercise capacity...
December 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29232209/recent-progress-in-understanding-hiv-reservoirs
#3
Hsiao-Hsuan Kuo, Mathias Lichterfeld
PURPOSE OF REVIEW: Reservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1. This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells. RECENT FINDINGS: Latently infected memory CD4 T cells are the predominant cell compartment responsible for viral persistence, but some studies suggest that myeloid cells, and possibly hematopoietic progenitors, can also serve as long-term viral reservoirs...
December 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29231614/-effects-of-preventative-moxibustion-on-ampk-and-mtor-in-myocardial-tissue-in-rats-with-exhaustive-exercise
#4
Haoran Zhang, Hongru Zhang, Shengfeng Lu, Hua Bai, Yihuang Gu
OBJECTIVE: To observe the effects of preventative moxibustion on adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in myocardial tissue in rats with exhaustive exercise, and to explore the action mechanism of preventative moxibustion for myocardial injury by exhaustive exercise. METHODS: Eighteen SD male rats were randomly divided into a blank group, an exhaustive exercise group and a moxibustion group, 6 rats in each one...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231481/-effects-of-auricular-point-sticking-on-plasma-motilin-in-patients-after-gynecological-laparoscopic-operation-under-general-anesthesia
#5
Tao Tao, Ting Chen, Aiming Yang, Hui Zheng, Mingyang Wei, Haiyan Jin, Xiaowen Guo
OBJECTIVE: To observe the clinical efficacy of auricular point sticking on prevention and treatment of gastrointestinal complications after gynecological laparoscopic operation of general anesthesia, and to explore whether it is achieved by regulating the secretion of plasma motilin (MTL). METHODS: Sixty patients who received selective gynecological laparoscopy under general anesthesia were randomly assigned into an observation group and a control group, 30 patients in each one...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231141/an-overview-on-the-importance-of-combining-complementary-analytical-platforms-in-metabolomic-research
#6
Alvaro Gonzalez-Dominguez, Enrique Duran-Guerrero, Angeles Fernandez-Recamales, Alfonso Maria Lechuga-Sancho, Ana Sayago, Monica Schwarz, Carmen Segundo, Raul Gonzalez-Dominguez
The analytical bias introduced by most of the commonly used techniques in metabolomics considerably hinders the simultaneous detection of all metabolites present in complex biological samples. In order to solve this limitation, the combination of complementary approaches is emerging in recent years as the most suitable strategy in order to maximize metabolite coverage. This review article presents a general overview of the most important analytical techniques usually employed in metabolomics: nuclear magnetic resonance, mass spectrometry and hybrid approaches...
December 11, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29230719/resveratrol-and-or-exercise-training-counteract-aging-associated-decline-of-physical-endurance-in-aged-mice-targeting-mitochondrial-biogenesis-and-function
#7
Marwa Hassan Muhammad, Mona Maher Allam
Mitochondrial dysfunction and decreased mitochondrial content are hallmarks of aging that leads to decreased physical endurance. Our aim was to explore the anti-aging effect of resveratrol (RSVT) supplementation, a polyphenol, and/or exercise training, started at an older age, on improving physical activity, therefore, help in frailty avoidance and promotion of healthy aging in elderly. Eighteen-month-old aged mice received RSVT (15 mg/kg/day) and/or exercise trained for 4 weeks showed significant longer time to exhaustion with decreased blood lactate and free fatty acids levels associated with improved oxidative stress evidenced by decreased gastrocnemius muscle lipid peroxidation and increased antioxidant enzymes activities, catalase and superoxide dismutase, when compared to aged mice control group...
December 11, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29230606/agreement-and-discrepancy-between-supervisor-and-clinician-alliance-associations-with-clinicians-perceptions-of-psychological-climate-and-emotional-exhaustion
#8
Jill Locke, Stephanie Violante, Michael D Pullmann, Suzanne E U Kerns, Nathaniel Jungbluth, Shannon Dorsey
Despite increasing interest in supervision as a leverage point for bolstering public mental health services, the potential influence of supervisory alliance on organizations and direct service providers remains understudied, particularly in the context of supporting evidence-based treatment (EBT) use. This study examined agreement and discrepancy between supervisor and clinician ratings of alliance associated with clinicians' perceptions of psychological climate and emotional exhaustion. Results indicated that discrepancies in alliance ratings were common and associated with clinicians' perceptions of psychological climate...
December 11, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29229969/transcriptome-and-metabolome-profiling-of-narcissus-pseudonarcissus-king-alfred-reveal-components-of-amaryllidaceae-alkaloid-metabolism
#9
Aparna Singh, Isabel Desgagné-Penix
Amaryllidaceae alkaloids (AAs) represent a diverse class of plant specialized metabolites and many display potent pharmacological activities. The AA metabolic pathway is poorly understood and resources are minimal. To enable AA pathway elucidation and novel biosynthetic enzymes discovery, we generated comprehensive metabolomic and corresponding transcriptomic datasets from different tissues of Narcissus pseudonarcissus 'King Alfred'. In this study, we performed untargeted UPLC-QTOF-MS metabolite analysis from different tissues, which generated exhaustive list of compounds, including several AAs, most predominant and diverse in bulbs...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227942/the-interaction-between-bacterial-abundance-and-selected-pollutants-concentration-levels-in-an-arctic-catchment-southwest-spitsbergen-svalbard
#10
Klaudia Kosek, Katarzyna Kozak, Krystyna Kozioł, Katarzyna Jankowska, Stanisław Chmiel, Żaneta Polkowska
Persistent organic pollutants (POPs) have been a topic of interest in environmental sciences for >60years. POPs in the Arctic have been investigated since the 1970s, when first atmospheric measurements revealed the presence of these pollutants in the polar regions. Major contaminant transport routes to the Arctic include atmospheric and oceanic transport, as well as inflow from rivers and sea ice. The sources of pollutants, such as industry, power generators, vehicle and ship exhausts, introduce the PAHs, phenols, formaldehyde or metals into the Arctic...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227121/-what%C3%A2-s%C3%A2-new-in-ewing-like-sarcoma-family-soft-tissue-and-bone-sarcomas-with-cic-bcor-rearrangement-review-of-the-literature-and-first-personal-experience
#11
Zdeněk Kinkor, Petr Grossmann, Magdaléna Dubová, David Bludovský, Andrea Černá, Lenka Krsková, Petr Lhoták
The literature is reviewed regarding of a rare molecularly defined group of sarcomas with rearrangement of both CIC and BCOR genes, which were originally placed into the EWSR1wt Ewing-like category. Personal experience with three cases demonstrating difficulties of this issue is added. Both groups of lesions differ not only by age and topography, but also vary in both the prognostic and the predictive parameters. CIC-rearranged tumors are very aggressive and almost never occur in the skeleton; in contrary, the BCOR-rearranged ones are predominantly bone tumors in young males behaving even better than classical Ewing sarcoma...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29227004/recurrence-of-uterine-myoma-after-myomectomy-open-myomectomy-versus-laparoscopic-myomectomy
#12
Yasushi Kotani, Takako Tobiume, Risa Fujishima, Mamoru Shigeta, Hisamitsu Takaya, Hidekatsu Nakai, Ayako Suzuki, Isao Tsuji, Masaki Mandai, Noriomi Matsumura
AIM: Open myomectomy (OM) was previously frequently performed; however, laparoscopic myomectomy (LM) has recently become more common. Nevertheless, myoma can recur after both LM and OM. In this study, we report our retrospective investigation of myoma recurrence by comparing LM and OM. METHODS: A total of 474 patients underwent LM and 279 patients underwent OM. The patients were followed-up postoperatively from six months to eight years. Recurrence was confirmed when a myoma with a diameter of ≥ 1 cm was detected...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29226556/solvent-or-thermal-extraction-of-ethylene-oxide-from-polymeric-materials-medical-device-considerations
#13
Anne D Lucas, Christopher Forrey, David M Saylor, Katherine Vorvolakos
Ethylene oxide (EO) gas is commonly used to sterilize medical devices. Bioavailable residual EO, however, presents a significant toxicity risk to patients. Residual EO is assessed using international standards describing extraction conditions for different medical device applications. We examine a series of polymers and explore different extraction conditions to determine residual EO. Materials were sterilized with EO and exhaustively extracted in water, in one of three organic solvents, or in air using thermal desorption...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29225582/significant-need-for-a-french-network-of-expert-centers-enabling-a-better-characterization-and-management-of-treatment-resistant-depression-fondation-fondamental
#14
Antoine Yrondi, Djamila Bennabi, Emmanuel Haffen, Marion Garnier, Frank Bellivier, Thierry Bourgerol, Vincent Camus, Thierry D'Amato, Olivier Doumy, Frédéric Haesebaert, Jérôme Holtzmann, Christophe Lançon, Philippe Vignaud, Fanny Moliere, Isabel Nieto, Raphaëlle Marie Richieri, Philippe Domenech, Corentin Rabu, Luc Mallet, Liova Yon, Laurent Schmitt, Florian Stephan, Guillaume Vaiva, Michel Walter, Pierre-Michel Llorca, Philippe Courtet, Marion Leboyer, Wissam El-Hage, Bruno Aouizerate
Background: Major depression is characterized by (i) a high lifetime prevalence of 16-17% in the general population; (ii) a high frequency of treatment resistance in around 20-30% of cases; (iii) a recurrent or chronic course; (iv) a negative impact on the general functioning and quality of life; and (v) a high level of comorbidity with various psychiatric and non-psychiatric disorders, high occurrence of completed suicide, significant burden along with the personal, societal, and economic costs...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29225482/the-relationship-between-empathy-and-burnout-lessons-for-paramedics-a-scoping-review
#15
REVIEW
Brett Williams, Rosalind Lau, Emma Thornton, Lauren S Olney
Background: The concepts of empathy and burnout are critical for practicing paramedics and the profession. While there has been an increasing body of research on the relationship between empathy and burnout with physicians and nurses, surprisingly, no research has been undertaken with paramedics. The aim of this scoping review was to explore the relationship between empathy and burnout. Method: A scoping review was performed based on Arskey and O'Malley's framework...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29225037/understanding-and-sensitizing-density-dependent-persistence-to-quinolone-antibiotics
#16
Arnaud Gutierrez, Saloni Jain, Prerna Bhargava, Meagan Hamblin, Michael A Lobritz, James J Collins
Physiologic and environmental factors can modulate antibiotic activity and thus pose a significant challenge to antibiotic treatment. The quinolone class of antibiotics, which targets bacterial topoisomerases, fails to kill bacteria that have grown to high density; however, the mechanistic basis for this persistence is unclear. Here, we show that exhaustion of the metabolic inputs that couple carbon catabolism to oxidative phosphorylation is a primary cause of growth phase-dependent persistence to quinolone antibiotics...
December 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29224864/breeding-a-better-cow-will-she-be-adaptable
#17
D P Berry
Adaption is a process that makes an individual or population more suited to their environment. Long-term adaptation is predicated on ample usable genetic variation. Evolutionary forces influencing the extent and dynamics of genetic variation in a population include random drift, mutation, recombination, selection, and migration; the relative importance of each differs by population (i.e., drift is likely to be more influential in smaller populations) and number of generations exposed to selection (i.e., mutation is expected to contribute substantially to genetic variability following many generations of selection)...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224832/the-pathogenesis-of-pulmonary-sarcoidosis-and-implications-for-treatment
#18
REVIEW
Karen C Patterson, Edward S Chen
Thoracic sarcoidosis is the most common form of sarcoidosis, encompassing a heterogeneous group of patients with a wide range of clinical features and associated outcomes. The distinction between isolated thoracic lymphadenopathy and pulmonary involvement matters. Morbidity is often higher, and long-term outcomes are worse for the latter. While inflammatory infiltrates in pulmonary sarcoidosis may resolve, persistent disease activity is common and can result in lung fibrosis. Given the distinct clinical features and natural history of pulmonary sarcoidosis, its pathogenesis may differ in important ways from other sarcoidosis manifestations...
December 7, 2017: Chest
https://www.readbyqxmd.com/read/29224501/experimental-validation-of-a-subject-specific-maximum-endurance-time-model
#19
Bin Liu, Liang Ma, Chi Chen, Zhanwu Zhang
This study aimed at experimentally validating a subject-specific maximum endurance time (MET) model. Thirty health participants (15 males and 15 females; Age: mean = 21.5 years, SD = 1.6 years) volunteered to conduct an isometric elbow flexion task until exhaustion. The endurance times of each participant were measured under relative exertion levels ranging from 30%MVC (Maximum Voluntary Contraction) to 70%MVC at 10% intervals. Assessment of the model showed that the intensity-endurance time relationship for each studied individual could be well fitted by the subject-specific MET model (R2 > 0...
December 9, 2017: Ergonomics
https://www.readbyqxmd.com/read/29223906/comparison-of-real-world-and-certification-emission-rates-for-light-duty-gasoline-vehicles
#20
Tanzila Khan, H Christopher Frey
U.S. light duty vehicles are subject to the U.S. Environmental Protection Agency (EPA) emission standards. Emission compliance is determined by certification testing of selected emissions from representative vehicles on standard driving cycles using chassis dynamometers. Test results are also used in many emission inventories. The dynamometer based emission rates are adjusted to provide the certification levels (CL), which must be lower than the standards for compliance. Although standard driving cycles are based on specific observations of real-world driving, they are not necessarily real-world representative...
December 7, 2017: Science of the Total Environment
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