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Total thyroidectomy

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https://www.readbyqxmd.com/read/28529577/aggressiveness-of-the-tall-cell-variant-of-papillary-thyroid-carcinoma-is-independent-of-the-tumor-size-and-patient-age
#1
Rocío Villar-Taibo, Diego Peteiro-González, José Manuel Cabezas-Agrícola, Elvin Aliyev, Francisco Barreiro-Morandeira, Clara Ruiz-Ponte, José M Cameselle-Teijeiro
The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28528472/early-prediction-of-hypocalcemia-following-thyroid-surgery-a-prospective-randomized-clinical-trial
#2
Alessandra Saba, Mauro Podda, Antonio Messina Campanella, Adolfo Pisanu
PURPOSE: The aim of this randomized-controlled trial was to validate the results of a previous prospective single-cohort observational study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (iPTH) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy. METHODS: From January 2014 to January 2015, 150 patients underwent total thyroidectomy in our department and were randomized into two groups...
May 20, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28528434/tall-cell-and-diffuse-sclerosing-variants-of-papillary-thyroid-cancer-outcome-and-predicting-value-of-risk-stratification-methods
#3
M Russo, P Malandrino, M Moleti, F Vermiglio, M A Violi, I Marturano, E Minaldi, R Vigneri, G Pellegriti, C Regalbuto
PURPOSE: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. METHODS: A consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6-24 months after initial treatment, re-classified on the basis of the response to therapy (ongoing risk stratification)...
May 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28523498/maldi-msi-analysis-of-cytological-smears-the-study-of-thyroid-cancer
#4
Niccolò Mosele, Andrew Smith, Manuel Galli, Fabio Pagni, Fulvio Magni
Fine needle aspiration (FNA) biopsies are the current gold-standard for the preoperative evaluation of thyroid nodules. However, a significant number of them (15-30%) are unable to be affirmatively diagnosed and are given an "indeterminate for malignancy" final report, meaning that the malignant nature of the thyroid nodule remains unknown and the recommended therapeutic approach is total thyroidectomy. Furthermore, cytomorphological evaluation of biopsies taken post-surgery indicates that approximately 80% of nodules within this group of patients are in fact benign, and the total thyroidectomy unwarranted...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28523362/transoral-endoscopic-thyroidectomy-our-initial-experience-using-a-new-endoscopic-technique
#5
Jun-Ook Park, Dong-Il Sun
BACKGROUND: A transoral approach has been experimentally introduced to the field of thyroid surgery and several groups in Asia have recently used the technique to treat patients. We performed transoral endoscopic thyroidectomies on patients with thyroid cancer or a benign tumor. METHODS: We reviewed the medical records of patients who underwent transoral endoscopic thyroid surgery between July 2016 and January 2017. A midline incision was made in the vestibule, and a 10 mm cannula was placed; then, the working space was widened by insufflating CO2 at a pressure of 5-6 mmHg...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28514192/diagnostic-and-treatment-patterns-among-children-adolescents-and-young-adults-with-thyroid-cancer-in-ontario-1992-2010
#6
Jason D Pole, Aleksandra M Zuk, Jonathan Daniel Wasserman
BACKGROUND: Thyroid carcinoma (TC) is rare in young children, with a sharp increase in incidence among adolescents and young adults (AYA), between 15 and 29 years of age. The incidence of TC is increasing worldwide. Limited prospective population-based data are available to describe diagnostic and treatment practices in this age group. This study undertook a population-based review of TC among 0 to 29-year-old individuals in Ontario, Canada, utilizing linked administrative data to describe the demographic and care patterns over nearly two decades...
May 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28513849/surgical-considerations-for-papillary-thyroid-microcarcinomas
#7
REVIEW
Laura Boucai, Victor Bernet, Ashok Shaha, Maisie L Shindo, Brendan C Stack, Robert M Tuttle
We reevaluate current treatment recommendations of papillary thyroid microcarcinomas taking into account the indolent behavior of these tumors, and the potential morbidity that may result from an unnecessary surgery. The goals of this communication are to: 1) provide surgeons and endocrinologists with the most up-to-date evidence on management of microcarcinomas, 2) outline appropriate instances for active surveillance, and 3) describe the role of surgical interventions for microcarcinomas including lobectomy, total thyroidectomy, and central neck dissection...
May 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28510122/anti-thyroglobulin-antibodies-do-not-significantly-increase-the-risk-of-finding-iodine-avid-metastases-on-post-radioactive-iodine-ablation-scan-in-low-risk-thyroid-cancer-patients
#8
F Nabhan, K Porter, L Senter, M D Ringel
OBJECTIVE: Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy...
May 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28506522/thick-tumor-capsule-is-a-valuable-risk-factor-for-distant-metastasis-in-follicular-thyroid-carcinoma
#9
Wataru Shimbashi, Iwao Sugitani, Kazuyoshi Kawabata, Hiroki Mitani, Kazuhisa Toda, Keiko Yamada, Yukiko Sato
OBJECTIVE: While the biological behavior of follicular thyroid carcinoma (FTC) has been studied in great detail using clinical experience, few studies have investigated pre- or intraoperative factors related to the risk of distant metastasis (DM) among patients with FTC. The aim of this study was to analyze the characteristics of FTC with DM. METHODS: This study retrospectively investigated 102 patients with FTC who underwent surgery between 1988 and 2013. We compared clinicopathological characteristics between FTC with and without DM...
May 12, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#10
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506418/timing-and-extension-of-lymphadenectomy-in-medullary-thyroid-carcinoma-a-case-series-from-a-single-institution
#11
Andrea Polistena, Alessandro Sanguinetti, Roberta Lucchini, Sergio Galasse, Massimo Monacelli, Stefano Avenia, Andrea Boccolini, Louis Banka Johnson, Nicola Avenia
BACKGROUND: Medullary thyroid carcinoma is an aggressive tumor and presents with significant morbidity and mortality and a high rate of lymph node metastases. The combination of total thyroidectomy and cervical lymphadenectomy is the essential treatment for those patients presenting with cervical lymph node metastases. MATERIALS AND METHODS: A retrospective analysis of 117 patients operated for medullary thyroid carcinoma over a period of 15 years at a single institution...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506413/nasotracheal-prolonged-safe-extubation-in-acute-respiratory-failure-post-thyroidectomy-an-efficacious-technique-to-avoid-tracheotomy-a-retrospective-analysis-of-a-large-case-series
#12
F Ferraro, C Gambardella, D Testa, L Santini, R Marfella, P Fusco, C P Lombardi, A Polistena, A Sanguinetti, N Avenia, G Conzo
BACKGROUND: Acute respiratory failure is a rare life threatening complication following thyroid surgery and its incidence is reported as high as 0.9%. Clinical presentation of severe acute respiratory failure is characterized by dyspnea, inspiratory airways distress, hypoxia and its standard current management is the orotracheal intubation and safe extubation. In case of persistent distress, tracheotomy is mandatory. The Authors, analysing a large acute respiratory failure clinical series, describe an innovative treatment of this severe condition: the nasotracheal prolonged safe extubation...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506412/rationality-in-prophylactic-central-neck-dissection-in-clinically-node-negative-cn0-papillary-thyroid-carcinoma-is-there-anything-more-to-say-a-decade-experience-in-a-single-center
#13
C Dobrinja, M Troian, T Cipolat Mis, G Rebez, S Bernardi, B Fabris, L Piscopello, P Makovac, F Di Gregorio, N de Manzini
AIM: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Despite its extremely favorable prognosis, cervical lymph node metastases are a common feature of PTC and a known independent risk factor for local recurrence. However, the role of prophylactic central neck dissection (PCND) remains a matter of debate in patients with clinically node-negative (cN0) PTC. To better clarify the current role of PCND in the surgical treatment of PTC, evaluating advantages and disadvantages of PCND and outcome of cN0 PTC patients who have been treated with either total thyroidectomy alone or in combination with PCND...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506411/partial-thyroidectomy-for-papillary-thyroid-microcarcinoma-is-completion-total-thyroidectomy-indicated
#14
C Dobrinja, M Pastoricchio, M Troian, F Da Canal, S Bernardi, B Fabris, N de Manzini
AIM: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence. Despite its excellent clinical outcomes, there is still debate regarding which surgical approach is more appropriate for PTMC, procedures including hemithyroidectomy (HT), total thyroidectomy (TT), and completion thyroidectomy (CT) after initial HT and histopathologic examination confirming a PTMC. Here we report our experience in the surgical management of PTMC. METHODS: We conducted a retrospective evaluation of all patients who received a postoperative diagnosis of PTMC between January 2001 and January 2016...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506409/the-surgical-approach-to-nodule-thyr-3-4-after-the-2-2014-nccn-and-2015-ata-guidelines
#15
Paolo Del Rio, Paola Pisani, Chiara Montana Montana, Simona Cataldo, Michela Marina, Graziano Ceresini
BACKGROUND: The incidence of palpables thyroid nodules in general population is 5% and the prevalence of non -palpable nodules is higher (35-60%) in the endemic goiter area. In the last years the new guidelines and new classification related to thyroid nodule have changed the indication to treat it. MATERIAL AND METHOD: We analyzed the patients treated from January 2013 to June 2016 for Thyr 3 and Thyr 4 thyroid nodule sec. Bethesda system. We have divided in I and II period related to the 2...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506408/genetics-of-medullary-thyroid-cancer-an-overview
#16
REVIEW
Giacomo Accardo, Giovanni Conzo, Daniela Esposito, Claudio Gambardella, Marco Mazzella, Filomena Castaldo, Carlo Di Donna, Andrea Polistena, Nicola Avenia, Vittorio Colantuoni, Dario Giugliano, Daniela Pasquali
Medullary thyroid carcinoma (MTC) represents 3-5% of thyroid cancers. 75% is sporadic and 25% is the dominant component of the hereditary multiple endocrine neoplasia (MEN) type 2 syndromes. Three different subtypes of MEN2, such as MEN2A, MEN2B, and Familial MTC (FMTC) have been defined, based on presence or absence of hyperparathyroidism, pheocromocytoma and characteristic clinical features. Mutations of the RET proto-oncogene are implicated in the pathogenesis of MTC, but there are many other mutational patterns involved...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506407/intraoperative-neuromonitoring-in-thyroid-surgery-is-the-two-staged-thyroidectomy-justified
#17
Pietro Giorgio Calò, Fabio Medas, Giovanni Conzo, Francesco Podda, Gian Luigi Canu, Claudio Gambardella, Giuseppe Pisano, Enrico Erdas, Angelo Nicolosi
BACKGROUND: The aim of this study was to evaluate the diagnostic accuracy of intraoperative neuromonitoring (IONM) in predicting postoperative nerve function during thyroid surgery and its consequent ability to assist the surgeon in intraoperative decision making. MATERIALS AND METHODS: A total of 2365 consecutive patients were submitted to thyroidectomy by the same surgical team. Group A included 1356 patients (2712 nerves at risk) in whom IONM was utilized, and Group B included 1009 patients (2018 nerves at risk) in whom IONM was not utilized...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28502882/single-incision-endoscopic-thyroidectomy-for-papillary-thyroid-cancer-a-pilot-study
#18
Jinbeom Cho, Yohan Park, Jongmin Baek, Kiyoung Sung
BACKGROUND: Recently, we have reported single incision endoscopic thyroidectomy using an axillary approach with gas inflation (SIET) in cases with benign thyroid tumors to reduce post-operative pain and invasiveness of the conventional endoscopic thyroidectomy. The aim of this study was to present our experiences with SIET for papillary thyroid cancer (PTC). METHODS: Patients who were diagnosed with histologically papillary thyroid carcinoma (≤1 cm) with single, unilateral, and intra-thyroidal lesion and without clinical lymph node metastasis were included...
May 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28493593/superior-parathyroid-gland-approach-to-the-recurrent-laryngeal-nerve
#19
Ezzeddin Elsheikh
BACKGROUND: The superior parathyroid gland is known to be almost constant in its location under the false thyroid capsule. Could it be a landmark to point to the site of incision of the false thyroid capsule and find the plane of the recurrent laryngeal nerve (RLN) during thyroidectomy? METHODS: The study included 48 patients with benign goiter scheduled for hemithyroidectomy or total thyroidectomy; there were 16 cases of solitary thyroid nodules, 27 cases of multinodular goiter, and 5 cases of toxic goiter...
May 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28493562/perioperative-practices-in-thyroid-surgery-an-international-survey
#20
Anastasios Maniakas, Apostolos Christopoulos, Eric Bissada, Louis Guertin, Marie-Jo Olivier, Jacques Malaise, Tareck Ayad
BACKGROUND: Perioperative practices in thyroid surgery vary from one specialty, institution, or country to the next. We evaluated the preoperative, intraoperative, and postoperative practices of thyroid surgeons focusing on preoperative ultrasound, vocal cord evaluation, wound drains, and hospitalization duration, among others. METHODS: A survey was sent to 7 different otolaryngology and endocrine/general surgery associations. RESULTS: There were 965 respondents from 52 countries...
May 11, 2017: Head & Neck
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