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https://www.readbyqxmd.com/read/29045694/machine-learning-approaches-to-decipher-hormone-and-her2-receptor-status-phenotypes-in-breast-cancer
#1
Emmanuel S Adabor, George K Acquaah-Mensah
Breast cancer prognosis and administration of therapies are aided by knowledge of hormonal and HER2 receptor status. Breast cancer lacking estrogen receptors, progesterone receptors and HER2 receptors are difficult to treat. Regarding large data repositories such as The Cancer Genome Atlas, available wet-lab methods for establishing the presence of these receptors do not always conclusively cover all available samples. To this end, we introduce median-supplement methods to identify hormonal and HER2 receptor status phenotypes of breast cancer patients using gene expression profiles...
October 16, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29045452/prospective-multicenter-french-study-evaluating-the-clinical-impact-of-the-breast-cancer-intrinsic-subtype-prosigna%C3%A2-test-in-the-management-of-early-stage-breast-cancers
#2
Delphine Hequet, Céline Callens, David Gentien, Benoit Albaud, Marie-Ange Mouret-Reynier, Coraline Dubot, Paul Cottu, Cyrille Huchon, Sonia Zilberman, Helene Berseneff, Cyril Foa, Rémy Salmon, Aurélie Roulot, Florence Lerebours, Anne Salomon, Nadeem Ghali, Pascale Morel, Qianyi Li, Anne Cayre, Jean-Marc Guinebretière, John Hornberger, Frédérique Penault-Llorca, Roman Rouzier
PURPOSE: The Prosigna® breast cancer prognostic gene signature assay identifies a gene-expression profile that permits the classification of tumors into subtypes and gives a score for the risk of recurrence (ROR) at 10 years. The primary objective of this multicenter study was to evaluate the impact of Prosigna's assay information on physicians' adjuvant treatment decisions in patients with early-stage breast cancer. Secondary objectives were to assess confidence of practitioners in their therapeutic recommendations before and after the added information provided by the Prosigna assay; and to evaluate the emotional state of patients before and after the Prosigna test results...
2017: PloS One
https://www.readbyqxmd.com/read/29043346/anti-obesity-molecular-mechanism-of-soy-isoflavones-weaving-the-way-to-new-therapeutic-routes
#3
REVIEW
Siyu Wang, Yu Wang, Min-Hsiung Pan, Chi-Tang Ho
Obesity is ringing alarm bells globally. Advances in food science and nutrition research have been devoted to identifying food components that exert anti-obesity effects, as well as investigating the molecular mechanisms by which they modulate the progression of obesity. Soy foods have attracted much interest as high-protein components of the human diet and as unique sources of isoflavones. As they have similar chemical structures to endogenous estrogens, isoflavones are believed to interact with intracellular estrogen receptors, which results in reductions in the accumulation of lipids and the distribution of adipose tissue...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29043101/protective-effect-of-rhus-verniciflua-stokes-extract-in-an-experimental-model-of-post-menopausal-osteoporosis
#4
Ji Heun Jeong, Jong Hoon An, Hui Yang, Do-Kyung Kim, Nam-Seob Lee, Young-Gil Jeong, Chun Soo Na, Dae Seung Na, Mi-Sook Dong, Seung Yun Han
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042923/er%C3%AE-compensates-for-the-absence-of-er%C3%AE-function-to-promote-osteoblast-viability-by-inhibition-of-sost-signaling
#5
Shijin Lu, Changying Sun, Congxiu Miao, Zhongfu Zhao
Estrogen receptors α and β (ERα and ERβ) serve key functions in bone development and maintenance, and in the metabolism of bone mineral. ERβ and ERα form heterodimers, and ERβ negatively regulates the transactivation of ERα. ERβ also inhibits recruitment of ERα to the estrogen-responsive promoters. However, the relationship of ERα and ERβ in the regulation of osteoblast viability and differentiation remains unclear. The present study aimed to investigate whether ERβ plays a role in balancing ERα activity in osteoblast cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042792/low-dose-of-kaempferol-suppresses-the-migration-and-invasion-of-triple-negative-breast-cancer-cells-by-downregulating-the-activities-of-rhoa-and-rac1
#6
Shoushan Li, Ting Yan, Rong Deng, Xuesong Jiang, Huaping Xiong, Yuan Wang, Qiao Yu, Xiaohua Wang, Cheng Chen, Yichao Zhu
PURPOSE: Triple-negative breast cancer (TNBC) is an especially aggressive and hard-to-treat disease. Although the anticancer role of kaempferol has been reported in breast cancer, the effect of kaempferol on TNBC remains unclear. MATERIALS AND METHODS: This experiment investigated the migration-suppressive role of a low dose of kaempferol in TNBC cells. Wound-healing assays and cell invasion assays were used to confirm the migration and invasion of cells treated with kaempferol or transfected indicated constructs...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29042199/temporal-expression-and-gonadotropic-regulation-of-aromatase-and-estrogen-receptors-in-the-ovary-of-wall-lizard-hemidactylus-flaviviridis-correlation-with-plasma-estradiol-and-ovarian-follicular-development
#7
Mamta Tripathy, Umesh Rai
The current study in Indian wall lizard Hemidactylus flaviviridis for the first time demonstrates the reproductive phase-dependent expression pattern of aromatase (cyp19) and estrogen receptor subtypes (er-α and er-β) as well as their gonadotropic regulation in the ovary of a squamate. The expression of cyp19 remained low during regressed phase, increased markedly in recrudescent and declined sharply in breeding phase. Further, temporal profile of plasma estradiol 17-β (E2) was found to be relatively parallel to the expression pattern of ovarian cyp19...
October 14, 2017: Steroids
https://www.readbyqxmd.com/read/29041905/clinicopathological-and-prognostic-significance-of-programmed-death-ligand-1-expression-in-breast-cancer-a-meta-analysis
#8
Hye Min Kim, Jinae Lee, Ja Seung Koo
BACKGROUND: Programmed cell death-ligand 1 (PD-L1) may be a useful molecule for targeted immunotherapy. Therefore, this meta-analysis aimed to investigate PD-L1 expression in breast cancer and its associations with clinicopathological factors and outcomes, which may help determine whether PD-L1 expression is a useful prognostic marker. METHODS: The Medline Ovid, Cochrane, PubMed, Google Scholar, and Web of Knowledge databases were searched for studies that evaluated the prognostic or clinicopathological significance of PD-L1 expression in patients with breast cancer, and reported at least one survival-related outcome...
October 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29040973/sulforaphane-and-epigallocatechin-gallate-restore-estrogen-receptor-expression-by-modulating-epigenetic-events-in-the-breast-cancer-cell-line-mda-mb-231-a-systematic-review-and-meta-analysis
#9
Vincenza Gianfredi, Samuele Vannini, Massimo Moretti, Milena Villarini, Nicola Luigi Bragazzi, Alberto Izzotti, Daniele Nucci
BACKGROUND/AIMS: Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro...
October 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29040006/neurokinin-3-receptor-antagonism-the-magic-bullet-for-hot-flushes
#10
J K Prague, W S Dhillo
Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes...
October 17, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29039776/roles-of-aryl-hydrocarbon-receptor-in-aromatase-dependent-cell-proliferation-in-human-osteoblasts
#11
Yasuhiro Miki, Shuko Hata, Katsuhiko Ono, Takashi Suzuki, Kiyoshi Ito, Hiroyuki Kumamoto, Hironobu Sasano
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and β-naphthoflavone (β-NF). AhR and its downstream genes, such as CYP1A1, are considered to play a pivotal role in xenobiotic responses. AhR signaling has also been proposed to mediate osteogenesis in experimental animals, but its details have remained unclear. Therefore, in this study, we examined the possible roles of AhR in human bone...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29039577/genome-wide-analysis-of-the-three-way-interplay-among-gene-expression-estrogen-receptor-expression-and-chemotherapeutic-sensitivity-in-breast-cancer
#12
Dong-Xu He, Xiao-Li Wu, Chun-Xiao Lu, Xiao-Ting Gu, Guang-Yuan Zhang, Xin Ma, De-Quan Liu
The expression of estrogen receptor α (ER) in breast cancers may be indicative of a favorable prognosis and most of these cancers respond to anti-estrogens or aromatase inhibitors. However, ER-positive (ER+) breast cancers receiving anti-hormone and/or chemotherapy sometimes lose their ER expression, which leads to the evolution of the disease to higher aggressiveness and drug resistance. In the present study, an ER-modified signature (EMS) was developed from the expression profile of a chemoresistant MCF-7 breast cancer cell line that lost ER expression during long-term treatment with a chemotherapeutic agent...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039060/the-incidence-of-urinary-tract-cancers-is-related-to-preserved-diuresis-a-single-center-report
#13
Vedran Premuzic, Marija Gamulin, Marijana Coric, Bojan Jelakovic
PURPOSE: Residual diuresis progressively decreases with longer dialysis vintage, and higher incidence of renal and urinary tract cancers was often observed in hemodialyzed patients compared to the general population so we hypothesized that patients without preserved residual diuresis have higher risk of renal and urinary tract cancers than patients with preserved residual diuresis. METHODS: Retrospective clinical data and pathology reports were completed for 307 uremic patients undergoing chronic hemodialysis...
October 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29037849/letrozole-induced-low-estrogen-levels-affected-the-expressions-of-duodenal-and-renal-calcium-processing-gene-in-laying-hens
#14
REVIEW
Qiao Li, Xingkai Zhao, Shujie Wang, Zhenlei Zhou
Estrogen regulates the calcium homeostasis in hens, but the mechanisms involved are still unclear fully. In this study, we investigated whether letrozole (LZ) induced low estrogen levels affected the calcium absorption and transport in layers. In the duodenum, we observed a significant decrease of mRNA expressions of Calbindin-28k (CaBP-28k) and plasma membrane Ca(2+)-ATPase (PMCA 1b) while CaBP-28k protein expression was declined in birds with LZ treatment, and the mRNA levels of duodenal transient receptor potential vanilloid 6 (TRPV6) and Na(+)/Ca(2+) exchanger 1 (NCX1) were not affected...
October 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29037750/environmental-toxicology-and-omics-a-question-of-sex
#15
Xuefang Liang, April Feswick, Denina Simmons, Christopher J Martyniuk
Molecular initiating events and downstream transcriptional/proteomic responses provide valuable information for adverse outcome pathways, which can be used predict the effects of chemicals on physiological systems. There has been a paucity of research that addresses sex-specific expression profiling in toxicology and due to cost, time, and logistical considerations, sex as a variable has not been widely considered. In response to this deficiency, federal agencies in the United States, Canada, and Europe have highlighted the importance of including sex as a variable in scientific investigations...
October 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29037533/continuous-tamoxifen-delivery-improves-locomotor-recovery-6h-after-spinal-cord-injury-by-neuronal-and-glial-mechanisms-in-male-rats
#16
Jennifer M Colón, Pablo A González, Ámbar Cajigas, Wanda I Maldonado, Aranza I Torrado, José M Santiago, Iris K Salgado, Jorge D Miranda
No treatment is available for patients with spinal cord injury (SCI). Patients often arrive to the hospital hours after SCI suggesting the need of a therapy that can be used on a clinically relevant window. Previous studies showed that Tamoxifen (TAM) treatment 24h after SCI benefits locomotor recovery in female rats. Tamoxifen exerts beneficial effects in male and female rodents but a gap of knowledge exists on: the therapeutic window of TAM, the spatio-temporal mechanisms activated and if this response is sexually dimorphic...
October 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29037132/expression-of-hormonal-carcinogenesis-genes-and-related-regulatory-micrornas-in-uterus-and-ovaries-of-ddt-treated-female-rats
#17
T S Kalinina, V V Kononchuk, L F Gulyaeva
The insecticide dichlorodiphenyltrichloroethane (DDT) is a nonmutagenic xenobiotic compound able to exert estrogen-like effects resulting in activation of estrogen receptor-α (ERα) followed by changed expression of its downstream target genes. In addition, studies performed over recent years suggest that DDT may also influence expression of microRNAs. However, an impact of DDT on expression of ER, microRNAs, and related target genes has not been fully elucidated. Here, using real-time PCR, we assessed changes in expression of key genes involved in hormonal carcinogenesis as well as potentially related regulatory oncogenic/tumor suppressor microRNAs and their target genes in the uterus and ovaries of female Wistar rats during single and chronic multiple-dose DDT exposure...
October 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29036268/breast-cancer-estrogen-receptor-by-biological-generation-us-black-white-women-born-1915-1979
#18
Nancy Krieger, Jaquelyn L Jahn, Pamela D Waterman, Jarvis T Chen
Evidence suggests contemporary population distributions of breast cancer estrogen receptor (ER) status may be shaped by earlier major societal events, such as the 1965 abolition of Jim Crow (legal racial discrimination in the US) and the Great Famine in China (1959-1961). We accordingly analyzed changes in ER status in relation to Jim Crow birth place among the 46,417 black and 339,830 white US-born non-Hispanic women in the 13 SEER Registry Group who were born between 1915 and 1979 and diagnosed (age 25-84, inclusive) between 1992-2012...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29035723/raloxifene-reduces-the-risk-of-local-alveolar-bone-destruction-in-a-mouse-model-of-periodontitis-combined-with-systemic-postmenopausal-osteoporosis
#19
Ryota Ichimaru, Tsukasa Tominari, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Yukihiro Numabe, Gillian Murphy, Hideaki Nagase, Chisato Miyaura, Masaki Inada
OBJECTIVE: Periodontitis is characterized by local inflammation leading to tooth loss and severe destruction of alveolar bone. Raloxifene is a selective estrogen receptor modulator (SERM) that halts estrogen deficiency-induced systemic bone loss in postmenopausal osteoporosis without the side effects of cancer in breast and uterus. In this study, we examined the effects of raloxifene on alveolar bone mass in a mouse model with estrogen deficiency-induced periodontitis. METHODS: Periodontitis was induced by the injection of lipopolysaccharide (LPS) into the lower gingiva in ovariectomized (OVX) mice, and the alveolar bone and femur bone mineral density (BMD) were analyzed by dual-energy X-ray absorptiometry...
September 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29035379/lobular-carcinoma-in-situ-and-invasive-lobular-breast-cancer-are-characterized-by-enhanced-expression-of-transcription-factor-ap-2%C3%AE
#20
Mieke Raap, Malte Gronewold, Henriette Christgen, Silke Glage, Mohammad Bentires-Alj, Shany Koren, Patrick W Derksen, Mirjam Boelens, Jos Jonkers, Ulrich Lehmann, Friedrich Feuerhake, Elna Kuehnle, Oleg Gluz, Ronald Kates, Ulrike Nitz, Nadia Harbeck, Hans H Kreipe, Matthias Christgen
Transcription factor AP-2β (TFAP2B) regulates embryonic organ development and is overexpressed in alveolar rhabdomyosarcoma, a rare childhood malignancy. Gene expression profiling has implicated AP-2β in breast cancer (BC). This study characterizes AP-2β expression in the mammary gland and in BC. AP-2β protein expression was assessed in the normal mammary gland epithelium, in various reactive, metaplastic and pre-invasive neoplastic lesions and in two clinical BC cohorts comprising >2000 patients. BCs from various genetically engineered mouse (GEM) models were also evaluated...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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