Ningning Mi, Zixin Liang, Man Yang, Jinyu Zhao, Liang Tian, Chongfei Huang, Peng Xie, Siqing Wu, Qiangsheng He, Yuxuan Sun, Yanyan Lin, Ping Yue, Bin Xia, Jinqiu Yuan, Wenbo Meng
OBJECTIVE: Genetic and lifestyles contribute to cholelithiasis, but the impact of adhering to healthy lifestyle on cholelithiasis risk remains uncertain. We aimed to assess combined lifestyle factors and a polygenic risk score on incident cholelithiasis. METHODS: We utilized cholelithiasis genome-wide association study (GWAS) data from FinnGen study, constructing varied polygenic risk score (PRS), and applied them to 317,640 UK Biobank participants. The relative and absolute risk of incident cholelithiasis associated with six well-established lifestyle risk factors, was evaluated and stratified by PRS (low risk [quintile 1], intermediate risk [quintiles 2-4] and high risk [quintile 5])...
March 26, 2024: Preventive Medicine