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Angela Blasimann, Simon Eberle, Manuel Markus Scuderi
BACKGROUND:  Soccer is seen as highly intensive sport with an increased injury rate. Male adults are the players with the highest injury incidence. Accordingly, the importance of core muscle strengthening to prevent injury has increased in the past few years. Up to date, core muscle strengthening plays an important role in different prevention programs, such as the "FIFA 11 +". The aim of this systematic review was to investigate the effect of core muscle strengthening on injury rate in male adult soccer players, including at least the known and easy exercises "plank" and "side plank", on injury rate in male adult soccer players...
March 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
Yilin Sun, Le Zhen, Ying Peng, Jiankun Wang, Fei Fei, Lixiang Aa, Wenjiao Jiang, Xue Pei, Li Lu, Jie Liu, Guangji Wang, Kun Hao
To improve bioavailability and provide resistance to deamination, an array of gemcitabine (dFdC) prodrugs carrying the acyl modifications has been successful in the optimization of pharmacokinetic properties of dFdC, but the reports about 4-N-carbobenzoxy-dFdC (Cbz-dFdC), a dFdC prodrug bearing alkyloxycarbonyl modification, are relatively rare. Notably, in vivo enzymatic hydrolysis was an absolutely essential factor for the activation of these prodrugs, which is correlated with the anti-tumor activity. Therefore, detailed metabolism studies of Cbz-dFdC should be carried out for a more authentic pharmacodynamic evaluation...
March 14, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Eric Seiti Yamanaka, Luis A Tortajada-Genaro, Nuria Pastor, Ángel Maquieira
The genotyping of a single-nucleotide polymorphism (SNP) is addressed through methods based on loop-mediated isothermal amplification (LAMP) combined with user-friendly optical read-outs to cover the current demand for point-of-care DNA biomarker detection. The modification of primer design and reaction composition improved the assay selectivity yielding allele-specific results and reducing false-positive frequency. Furthermore, the reduced cost, ease of use and effectiveness of colorimetric detection (solution and hybridisation chip formats) were availed for the image capture by a smartphone, reching high sensitivity...
March 8, 2018: Biosensors & Bioelectronics
Sara Tze Kwan Li, Janet Hui-Wen Hsiao
Music notation and English word reading both involve mapping horizontally arranged visual components to components in sound, in contrast to reading in logographic languages such as Chinese. Accordingly, music-reading expertise may influence English word processing more than Chinese character processing. Here we showed that musicians named English words significantly faster than non-musicians when words were presented in the left visual field/right hemisphere (RH) or the center position, suggesting an advantage of RH processing due to music reading experience...
March 17, 2018: Cognition
Shuangshuang Ma, Chen Fang, Xiaoxi Sun, Lujia Han, Xueqin He, Guangqun Huang
Bacteria play an important role in organic matter degradation and maturity during aerobic composting. This study analyzed composting with or without a membrane cover in laboratory-scale aerobic composting reactor systems. 16S rRNA gene analysis was used to study the bacterial community succession during composting. The richness of the bacterial community decreased and the diversity increased after covering with a semi-permeable membrane and applying a slight positive pressure. Principal components analysis based on operational taxonomic units could distinguish the main composting phases...
March 14, 2018: Bioresource Technology
Dolores Sánchez-Rodríguez, Cédric Annweiler, Natalia Ronquillo-Moreno, Andrea Tortosa-Rodríguez, Anna Guillén-Solà, Olga Vázquez-Ibar, Ferran Escalada, Josep M Muniesa, Ester Marco
BACKGROUND: Malnutrition is a prevalent condition related to adverse outcomes in older people. Our aim was to compare the diagnostic capacity of the malnutrition criteria of the European Society of Parenteral and Enteral Nutrition (ESPEN) with other classical diagnostic tools. METHODS: Cohort study of 102 consecutive in-patients ≥70 years admitted for postacute rehabilitation. Patients were considered malnourished if their Mini-Nutritional Assessment-Short Form (MNA-SF) score was ≤11 and serum albumin <3 mg/dL or MNA-SF ≤ 11, serum albumin <3 mg/dL, and usual clinical signs and symptoms of malnutrition...
March 16, 2018: Archives of Gerontology and Geriatrics
Akhilesh Kumar, Manas Ranjan Dikhit, Ajay Amit, Amir Zaidi, Raj Kishor Pandey, Ashish Kumar Singh, Shashi S Suman, Vahab Ali, Vidya Nand Rabi Das, Krishna Pandey, Vikas Kumar, Shubhankar Kumar Singh, Shyam Narayan, Hirendra Kumar Chourasia, Pradeep Das, Sanjiva Bimal
We report here a Leishmania donovani ornithine decarboxylase (Ld-ODC) gene used as a DNA vaccine against visceral leishmaniasis in a murine Balb/c mouse model. This study also evaluated the possible mechanism of action directed by this candidate. We found a Th1 immune response after immunization using an Ld-ODC DNA vaccine, with results based on the rearrangement of TCR-V-α-2, proliferation of Carboxy fluorescein Succinimidyle ester positive T cells, which were able to produce cytokines such as TNF-α, IFN-γ, IL-12 and IL-2, but not IL-4, IL-5, IL-6 and IL-10, and modulations of the STAT-1 and p38 MAP kinase signaling pathways...
March 17, 2018: Molecular Immunology
Heléne F Dorfling, Zarina Lockhat, Samantha Pretorius, Maryna Steyn, Anna C Oettlé
Although guidelines for facial approximations, including those for the eye, are in use in South Africa, limited data on African populations exist to confirm its validity. As precise placement of the eyes in facial approximations is of importance for facial recognition, this study tested established guidelines by measuring specific instrumental dimensions. Forty-nine cadavers from the Sefako Makgatho Health Sciences University and the University of Pretoria were dissected to determine the position of the canthi and the size and position of the eyeball in the orbit...
March 8, 2018: Forensic Science International
Marc Sorel, Naaman Zrek, Blanche Locko, Catherine Armessen, Samar S Ayache, Jean-Pascal Lefaucheur
OBJECTIVE: To evaluate the changes in glutamate/GABA balance of intracortical excitability produced by ketamine, delivered at subanaesthetic dose to treat patients with complex regional pain syndrome (CRPS). METHODS: In 19 patients with CRPS, we assessed the effect of a 5-day ketamine protocol on various clinical aspects, including pain and depression, and on cortical excitability parameters provided by transcranial magnetic stimulation testing. RESULTS: The rest motor threshold (RMT) and the amplitude of the motor evoked potentials at 120% of RMT were not modified after ketamine therapy...
March 8, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Lucy A Stephenson, Katherine Beck, Paula Busuulwa, Camilla Rosan, Carmine M Pariante, Susan Pawlby, Vaheshta Sethna
Childhood sexual abuse (CSA) is a worldwide problem with severe long-term consequences. A history of CSA can impact the childbearing experience of mothers and fathers; affecting their mental health, parenting skills and compromising infant development. Nonetheless, the perinatal period offers huge opportunity for intervention and hope. This literature review collates evidence for perinatal psychosocial interventions targeting both mothers and fathers who are survivors of CSA. Publications dating from 1970 to June 2016 were searched using Medline, Maternity and Infant Health, PsychINFO, PsychArticles, PubMed and the International Bibliography of the Social Sciences (IBSS)...
March 17, 2018: Child Abuse & Neglect
Bo Gan, Bei Li, Haipeng Jiang, Mingshu Bi, Wei Gao
The suppressions of ultrafine water mists containing additives (NaCl and NaHCO3 ) on 100 nm, 5 μm, and 30 μm polymethyl methacrylate (PMMA) dust explosions were experimentally studied in a dust-explosion apparatus. High-speed photography showed that maximum vertical positions and flame propagation velocities were significantly decreased by suppression with ultrafine water mist/additives. Flame propagation velocities in 100 nm, 5 μm, and 30 μm dust explosions suppressed by the ultrafine pure water mist were reduced by 48...
March 10, 2018: Journal of Hazardous Materials
Yu-Jun Zheng, Xiao-Han Zhou, Wei-Guo Sheng, Yu Xue, Sheng-Yong Chen
Recently telecom fraud has become a serious problem especially in developing countries such as China. At present, it can be very difficult to coordinate different agencies to prevent fraud completely. In this paper we study how to detect large transfers that are sent from victims deceived by fraudsters at the receiving bank. We propose a new generative adversarial network (GAN) based model to calculate for each large transfer a probability that it is fraudulent, such that the bank can take appropriate measures to prevent potential fraudsters to take the money if the probability exceeds a threshold...
March 5, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Bradley Fawver, Jaimie A Roper, Carolina Sarmento, Chris J Hass
We investigated the impact of initial body position on the displacement and velocity of center of pressure adjustments made during gait initiation. Twenty-nine healthy adults (21 ± 1y) initiated forward gait following six seconds of sustained forward posture based on percentage of their forward maximum voluntary lean (0, 5, 10, 20, 50%). Final center of pressure positions for each trial were back-calculated, as a percentage of maximum voluntary lean, using average anteroposterior constant error to the target during the last second of feedback...
March 17, 2018: Human Movement Science
É Duvelle, K J Jeffery
How does the brain represent the location of others? Recordings in rats and bats show that, along with representing self-location in an environment, some hippocampal neurons are modulated by the position of another individual.
March 19, 2018: Current Biology: CB
Lei Zhang, Xin Liu, Guimin Meng, Min Chi, Jingguang Li, Shuaixing Yin, Yunfeng Zhao, Yongning Wu
Several studies support a plausible association of human exposure to polychlorinated biphenyls (PCBs) with type 2 diabetes mellitus. However, little is known about the potential link between circulating PCBs levels in early pregnancy and development of gestational diabetes mellitus (GDM). Here, we conducted a prospective study with a nested case-control design to determine the association of PCB exposure in early pregnancy with GDM risk. Concentrations of selected so-called 'indicator PCBs' were determined in sera of women in the first trimester of pregnancy via gas chromatography - high resolution mass spectrometry...
March 17, 2018: Environment International
Xiaowei Cong, Xijin Xu, Long Xu, Minghui Li, Cheng Xu, Qilin Qin, Xia Huo
Air pollution is a risk factor for cardiovascular disease (CVD), and cardiovascular regulatory changes in childhood contribute to the development and progression of cardiovascular events at older ages. The aim of the study was to investigate the effect of air pollutant exposure on the child sympatho-adrenomedullary (SAM) system, which plays a vital role in regulating and controlling the cardiovascular system. Two plasma biomarkers (plasma epinephrine and norepinephrine) of SAM activity and heart rate were measured in preschool children (n = 228) living in Guiyu, and native (n = 104) and non-native children (n = 91) living in a reference area (Haojiang) for >1 year...
March 17, 2018: Environment International
Joseph A Wonderlich, Lauren Breithaupt, James C Thompson, Ross D Crosby, Scott G Engel, Sarah Fischer
Stress and affect have been implicated in the maintenance of binge eating for women with symptoms of bulimia nervosa (BN). Neuroimaging and ecological momentary assessment (EMA) have separately examined how these variables may contribute to eating disorder behavior. Though both methodologies have their own strengths, it's unclear how either methodology might inform the other. This study examined the impact of individual differences in neural reactivity to food cues following acute stress on the trajectories of positive affect (PA) and negative affect (NA) surrounding binge eating...
March 14, 2018: Journal of Psychiatric Research
T W Pike, F Mushtaq, R P Mann, P Chambers, G Hall, J E Tomlinson, R Mir, R M Wilkie, M Mon-Williams, J P A Lodge
BACKGROUND: Recent reviews suggest that the way in which surgeons prepare for a procedure (warm up) can affect performance. Operating lists present a natural experiment to explore this phenomenon. The aim was to use a routinely collected large data set on surgical procedures to understand the relationship between case list order and operative performance. METHOD: Theatre lists involving the 35 procedures performed most frequently by senior surgeons across 38 private hospitals in the UK over 26 months were examined...
March 20, 2018: British Journal of Surgery
Kimberly S Chiew, Jordan Hashemi, Lee K Gans, Laura Lerebours, Nathaniel J Clement, Mai-Anh T Vu, Guillermo Sapiro, Nicole E Heller, R Alison Adcock
Volitional exploration and learning are key to adaptive behavior, yet their characterization remains a complex problem for cognitive science. Exploration has been posited as a mechanism by which motivation promotes memory, but this relationship is not well-understood, in part because novel stimuli that motivate exploration also reliably elicit changes in neuromodulatory brain systems that directly alter memory formation, via effects on neural plasticity. To deconfound interrelationships between motivation, exploration, and memory formation we manipulated motivational state prior to entering a spatial context, measured exploratory responses to the context and novel stimuli within it, and then examined motivation and exploration as predictors of memory outcomes...
2018: PloS One
Akim Felipe Santos Nobre, Danilo de Souza Almeida, Louise Canto Ferreira, Deimy Lima Ferreira, Edivaldo Costa Sousa Júnior, Maria de Nazaré do Socorro de Almeida Viana, Ingrid Christiane Silva, Bruna Teles Pinheiro, Stephen Francis Ferrari, Alexandre da Costa Linhares, Edna Aoba Ishikawa, Rita Catarina Medeiros Sousa, Maísa Silva de Sousa
The Human T-cell Lymphotropic Virus (HTLV-1) is a Deltaretrovírus that was first isolated in the 1970s, and associated with Adult T-cell Leucemia-Lymphoma (ATLL), and subsequently to Tropical Spastic Paraparesis-Myelopathy (TSP/HAM). The genetic diversity of the virus varies among geographic regions, although its mutation rate is very low (approximately 1% per thousand years) in comparison with other viruses. The present study determined the genetic diversity of HTLV-1 in the metropolitan region of Belém, in northern Brazil...
2018: PloS One
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