keyword
https://read.qxmd.com/read/38567181/editorial-multisystem-inflammatory-syndrome-in-children
#21
EDITORIAL
Angela Mauro, Teresa Giani
No abstract text is available yet for this article.
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38560160/relationships-between-acute-generalized-eruptive-pustulosis-age-sex-primary-disease-and-prescription-medications-further-analysis-of-the-japanese-adverse-drug-event-report-database
#22
JOURNAL ARTICLE
Moe Yamashita, Mika Maezawa, Wataru Wakabayashi, Sakiko Hirofuji, Koumi Miyasaka, Nanaka Ichihara, Yuka Nokura, Kensuke Matsui, Satoshi Nakao, Hiroyuki Tanaka, Mitsuhiro Nakamura
BACKGROUND: Acute generalized eruptive pustulosis (AGEP) is a rare, but serious, drug-related adverse event. This study aimed to determine the relationships between AGEP and age, sex, primary disease, and prescription medications using a database of adverse drug events, namely, the Japanese Adverse Drug Event Report (JADER) database. METHODS: In this retrospective observational study, we analyzed AGEP reports extracted from the JADER database based on the preferred term for AGEP (code 10048799)...
April 15, 2024: Heliyon
https://read.qxmd.com/read/38556331/impact-of-hemoglobin-level-white-blood-cell-count-renal-dysfunction-and-staphylococcus-as-the-causative-organism-on-prediction-of-in-hospital-mortality-from-infective-endocarditis
#23
JOURNAL ARTICLE
Masamichi Koike, Takahiro Doi, Koki Morishita, Kosuke Uruno, Mirei Kawasaki-Nabuchi, Kaoru Komuro, Hiroyuki Iwano, Syuichi Naraoka, Daigo Nagahara, Satoshi Yuda
Infective endocarditis (IE) is a highly fatal disease in cases of delayed diagnosis and treatment, although its incidence is low. However, there have been few single-center studies in which the risk of in-hospital death from IE was stratified according to laboratory findings on admission and the organism responsible for IE. In this study, a total of 162 patients who were admitted to our hospital during the period from 2009 to 2021, who were suspected of having IE according to the modified Duke classification, and for whom IE was confirmed by transesophageal echocardiography were retrospectively analyzed...
2024: International Heart Journal
https://read.qxmd.com/read/38553078/time-elapsed-from-definitive-diagnosis-to-surgery-for-osteonecrosis-of-the-femoral-head-a-nationwide-observational-study-in-japan
#24
JOURNAL ARTICLE
Junichi Nakamura, Wakaba Fukushima, Wataru Ando, Shigeo Hagiwara, Yuya Kawarai, Yuki Shiko, Yohei Kawasaki, Takashi Sakai, Kazuya Ito, Yoshiya Arishima, Etsuo Chosa, Yusuke Fujimoto, Kazuo Fujiwara, Yukiharu Hasegawa, Shinya Hayashi, Takashi Imagama, Yutaka Inaba, Yasuyuki Ishibashi, Yasuhiro Ishidou, Hideya Ito, Hiroshi Ito, Juji Ito, Tetsuya Jinno, Tamon Kabata, Nobuhiro Kaku, Ayumi Kaneuji, Shunji Kishida, Seneki Kobayashi, Setsuro Komiya, Toshikazu Kubo, Tokifumi Majima, Naohiko Mashima, Masaaki Mawatari, Hidenobu Miki, Kazumasa Miyatake, Goro Motomura, Satoshi Nagoya, Hiroaki Nakamura, Yoshihide Nakamura, Ryosuke Nakanishi, Yasuharu Nakashima, Satoshi Nakasone, Takashi Nishii, Takayuki Nishiyama, Yoichi Ohta, Kenji Ohzono, Makoto Osaki, Kan Sasaki, Taisuke Seki, Takaaki Shishido, Takeshi Shoji, Akihiro Sudo, Michiaki Takagi, Daisuke Takahashi, Masaki Takao, Sakae Tanaka, Takeyuki Tanaka, Tomonori Tetsunaga, Keiichiro Ueshima, Kengo Yamamoto, Takuaki Yamamoto, Yuji Yamamoto, Takuma Yamasaki, Yuji Yasunaga, Nobuhiko Sugano
OBJECTIVES: This study documents the time elapsed from the diagnosis of osteonecrosis of the femoral head (ONFH) to surgery, exploring the factors that influence ONFH severity. DESIGN: Retrospective observational study of a nationwide database. SETTING: The Kaplan-Meier method with log-rank tests was applied to examine the period from definitive diagnosis of ONFH to surgery using any surgery as the end point. For bilateral cases, the date of the first surgery was the endpoint...
March 29, 2024: BMJ Open
https://read.qxmd.com/read/38551536/galectin-10-in-serum-extracellular-vesicles-reflects-asthma-pathophysiology
#25
JOURNAL ARTICLE
Hanako Yoshimura, Yoshito Takeda, Yuya Shirai, Makoto Yamamoto, Daisuke Nakatsubo, Saori Amiya, Takatoshi Enomoto, Reina Hara, Yuichi Adachi, Ryuya Edahiro, Moto Yaga, Kentaro Masuhiro, Taro Koba, Miho Itoh-Takahashi, Mana Nakayama, So Takata, Yuki Hosono, Sho Obata, Masayuki Nishide, Akinori Hata, Masahiro Yanagawa, Satoko Namba, Michio Iwata, Momoko Hamano, Haruhiko Hirata, Shohei Koyama, Kota Iwahori, Izumi Nagatomo, Yasuhiko Suga, Kotaro Miyake, Takayuki Shiroyama, Kiyoharu Fukushima, Shinji Futami, Yujiro Naito, Takahiro Kawasaki, Kenji Mizuguchi, Yusuke Kawashima, Yoshihiro Yamanishi, Jun Adachi, Mari Nogami-Itoh, Shigeharu Ueki, Atsushi Kumanogoh
BACKGROUND: Novel biomarkers (BMs) are urgently needed for bronchial asthma (BA) with various phenotypes and endotypes. OBJECTIVE: We sought to identify novel BMs reflecting tissue pathology from serum extracellular vesicles (EVs). METHODS: We performed data-independent acquisition of serum EVs from 4 healthy controls, 4 noneosinophilic asthma (NEA) patients, and 4 eosinophilic asthma (EA) patients to identify novel BMs for BA. We confirmed EA-specific BMs via data-independent acquisition validation in 61 BA patients and 23 controls...
March 14, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38551224/severe-late-cardiovascular-sequelae-of-kawasaki-disease-in-a-young-adult
#26
Stefanie Marek-Iannucci, Joey Junarta, Alec Vishnevsky, Indranee N Rajapreyar, James Jeffrey Fradin, Moshe Arditi, Andrew Peters, Yair Lev, Yevgeniy Brailovsky
No abstract text is available yet for this article.
March 29, 2024: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/38545188/susceptibility-of-tspan5-polymorphisms-to-kawasaki-disease-and-immunoglobulin-therapy-resistance-in-southern-chinese-children
#27
JOURNAL ARTICLE
Kaining Chen, Xilian Luo, Huazhong Zhou, Lanyan Fu, Zhaojin Lu, Chenlu Wang, Yueling Lin, Hongyan Yu, Yufen Xu, Lei Pi, Di Che, Zhouping Wang, Xiaoqiong Gu
Kawasaki disease (KD) is a condition characterized by acute multi-system vasculitis and high fever in infants and children. Intravenous immunoglobulin (IVIG) is the established therapeutic approach of KD,foralleviating inflammation and mitigate the risk of arterial wall dilation and the development of coronary artery aneurysms (CAA). But almost 20% of the patients developed resistance to IVIG and displayed persistent fever after standard primary treatment. TSPAN5 , belonging to the Tetraspanin family, has been demonstrated to modulate innate immunity in a range of human diseases...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38541678/vaers-vasculitis-adverse-events-retrospective-study-etiology-model-of-immune-complexes-activating-fc-receptors-in-kawasaki-disease-and-multisystem-inflammatory-syndromes
#28
JOURNAL ARTICLE
Darrell O Ricke, Nora Smith
BACKGROUND: Vasculitis diseases include Kawasaki disease (KD), Kawasaki disease shock syndrome (KDSS), Multisystem Inflammatory Syndrome (MIS), Henoch-Schönlein purpura (HS), or IgA vasculitis, and additional vasculitis diseases. These diseases are often preceded by infections or immunizations. Disease incidence rates are higher in children than in adults. These diseases have been extensively studied, but understanding of the disease etiology remains to be established. OBJECTIVE: Many studies have failed to demonstrate an association between vasculitis diseases and vaccination; this study examines possible associations...
March 7, 2024: Life
https://read.qxmd.com/read/38538656/combination-of-s100a12-tlr2-signaling-molecules-and-clinical-indicators-in-a-new-predictive-model-for-ivig-resistant-kawasaki-disease
#29
JOURNAL ARTICLE
Yali Wu, Pan Liu, Yang Zhou, Youjun Yang, Shiyu Li, Wei Yin, Fan Liu, Yan Ding
Although intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) presents with persistent inflammatory stimulation of the blood vessels and an increased risk of coronary artery dilatation. However, the pathogenesis of this disease is unclear, with no established biomarkers to predict its occurrence. This study intends to explore the utility of S100A12/TLR2-related signaling molecules and clinical indicators in the predictive modeling of IVIG-resistant KD. The subjects were classified according to IVIG treatment response: 206 patients in an IVIG-sensitive KD group and 49 in an IVIG-resistant KD group...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38534913/association-of-previous-antibiotics-use-and-kawasaki-disease-a-cohort-study-of-106-908-patients
#30
JOURNAL ARTICLE
Tae-Hwan Kim, Ji Seong Shin, Sin Young Kim, Jihye Kim
BACKGROUND: Microbial imbalance in the gut from antibiotic use may be an etiologic factor of Kawasaki disease (KD). We aimed to identify the association between the use of antibiotics and the development of KD, considering various antibiotic profiles. METHODS: A population-based, case-control study was performed using data from the Health Insurance Review and Assessment Service database. Children <5 years of age, who were diagnosed with KD between 2016 and 2019, were identified...
March 25, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38534044/effect-of-a-plant-protein-rich-diet-on-postprandial-phosphate-metabolism-in-healthy-adult-men-a-randomised-controlled-trial
#31
JOURNAL ARTICLE
Kozue Uenishi, Nozomi Kawasaki, Haruka Iseki, Misato Nogata, Yuki Kawabata, Shinsuke Kido
BACKGROUND: This study examined the effects of animal protein- and plant protein-rich diets on postprandial phosphorus metabolism in healthy male subjects. METHODS: The study was conducted by randomised parallel-group comparison of healthy men aged 21-24 years. In Study 1, participants were divided into two groups and consumed either a 70% animal protein diet (AD, n = 6) or a 70% plant protein diet (PD, n = 6). In Study 2, participants were divided into three groups and consumed either AD (n = 10), PD (n = 10) or AD + DF, a 70% animal protein diet loaded with the same amount of fibre as PD (n = 9)...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38532400/knowledge-attitudes-and-practices-towards-kawasaki-disease-from-caregivers-of-children-with-kawasaki-disease-a-cross-sectional-study
#32
JOURNAL ARTICLE
Miaomiao Zhao, Jiaxin Ye, Luping Chen, Yitong Yang, Meng Zhao, Mingzhu Yang, Zhaoling Shi
PURPOSE: To examine the knowledge, attitudes, and practices (KAP) of caregivers of children with Kawasaki disease toward Kawasaki disease. METHODS: This cross-sectional study was conducted at four hospitals in China from March 2023 to June 2023. The KAP scores were evaluated using a self-designed questionnaire (Cronbach's α = 0.840; KMO = 0.7381). Correlations between dimension scores were evaluated by Pearson correlation analysis...
March 26, 2024: BMC Public Health
https://read.qxmd.com/read/38524973/coronary-artery-aneurysms-following-repair-of-transposition-of-the-great-arteries
#33
Nikkan Das, Nazia Husain, Jyothy J Puthumana, Michael R Carr, Shivani G Patel
• Periodic surveillance after ASO for TGA with multimodality imaging is recommended. • New aneurysms may be detected in patients with antecedent KD. • KD should be suspected in patients with CAA even without previously known illness.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524885/primary-severe-pulmonary-and-tricuspid-valve-regurgitation-in-an-adult-patient
#34
Kazuki Yoshida, Haruka Sasaki, Hiroyuki Takaoka, Rei Hashimoto, Kenji Kawasaki, Goro Matsumiya, Kazuyuki Matsushita, Yoshio Kobayashi
• Severe progressive PR and TR in adults without histories of cardiac surgery is rare. • Carcinoid heart disease is an important differential in isolated PR and TR. • Three-dimensional TTE is helpful in identifying morphologic abnormalities of the PV. • CCT and cardiovascular magnetic resonance also help evaluate structures near the PV.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524347/ocular-nodular-fasciitis-in-kawasaki-disease
#35
JOURNAL ARTICLE
Sashwanthi Mohan, Madhuvanthi Mohan, Sujatha Mohan
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38521840/post-marketing-surveillance-of-the-safety-and-effectiveness-of-nivolumab-for-classic-hodgkin-lymphoma-in-japan
#36
JOURNAL ARTICLE
Akira Kawasaki, Kiyohiko Hatake, Itaru Matsumura, Koji Izutsu, Tomohiro Hoshino, Ayumi Akamatsu, Akito Kakuuchi, Kensei Tobinai
Nivolumab was approved for relapsed/refractory classic Hodgkin lymphoma (cHL) in Japan in 2016. After its approval, a prospective, non-interventional, observational post-marketing surveillance was initiated to evaluate the safety and effectiveness of nivolumab treatment for up to 12 months in patients with relapsed/refractory cHL. Of 304 registered patients, 288 were included in safety analyses and 282 in effectiveness analyses. There were 191 (66.3%) male patients, median age was 64.0 years, and 54 patients (18...
March 23, 2024: International Journal of Hematology
https://read.qxmd.com/read/38519783/prognostic-role-of-preoperative-chemotherapy-in-liver-limited-metastasis-from-gastric-cancer
#37
JOURNAL ARTICLE
Yuki Hirose, Masaki Aizawa, Hiroshi Yabusaki, Tatsuya Nomura, Kabuto Takano, Takashi Kawasaki, Gen Watanabe, Yukio Shimojima, Kizuki Yuza, Takeo Bamba, Satoru Nakagawa
BACKGROUND: We investigated the prognostic role of preoperative chemotherapy in patients who underwent hepatectomy for liver-limited metastasis (LLM) from gastric cancer (GC). METHODS: A retrospective analysis was conducted for 52 consecutive patients who underwent macroscopically complete (R0 or R1) resection for synchronous or metachronous LLM from GC. RESULTS: Of the 52 patients, 18 (35%) received preoperative chemotherapy (PC group), while 34 (65%) underwent upfront surgery (US group)...
March 22, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38516039/correlation-of-telomere-length-in-brain-tissue-with-peripheral-tissues-in-living-human-subjects
#38
JOURNAL ARTICLE
Annemarie J Carver, Benjamin Hing, Benjamin A Elser, Stephanie J Lussier, Takehiko Yamanashi, Matthew A Howard, Hiroto Kawasaki, Gen Shinozaki, Hanna E Stevens
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery ( n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38512940/accessible-luminal-interface-of-bovine-rectal-organoids-generated-from-cryopreserved-biopsy-tissues
#39
JOURNAL ARTICLE
Minae Kawasaki, Yoko M Ambrosini
Developing precise species-specific in vitro models that closely resemble in vivo intestinal tissues is essential for advancing our understanding of gastrointestinal physiology and associated diseases. This is especially crucial in examining host-pathogen interactions, particularly in bovines, a known reservoir for microbes and pathogens posing substantial public health threats. This research investigated the viability of producing bovine rectal organoids from cryopreserved tissues. We compared two cryopreservation methods with a traditional technique using fresh tissues, evaluating their effectiveness through growth rates, long-term viability, and comprehensive structural, cellular, and genetic analyses...
2024: PloS One
https://read.qxmd.com/read/38510083/case-report-identification-of-a-card8-variant-in-all-three-patients-with-pfapa-syndrome-complicated-with-kawasaki-disease
#40
Haruhiko Nakamura, Atsuo Kikuchi, Hideyuki Sakai, Miki Kamimura, Yohei Watanabe, Ryoichi Onuma, Jun Takayama, Gen Tamiya, Yoichi Mashimo, Ryota Ebata, Hiromichi Hamada, Tomohiro Suenaga, Yoshihiro Onouchi, Satoru Kumaki
BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in the immunopathogenesis of both diseases has been previously described. CASE PRESENTATION: Herein, we report the clinical courses of three patients who presented a rare combination of PFAPA syndrome and KD. Two patients who presented KD later developed the PFAPA syndrome, of whom one developed recurrent KD 2 years after the initial diagnosis...
2024: Frontiers in Pediatrics
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