keyword
https://read.qxmd.com/read/38534913/association-of-previous-antibiotics-use-and-kawasaki-disease-a-cohort-study-of-106-908-patients
#1
JOURNAL ARTICLE
Tae-Hwan Kim, Ji Seong Shin, Sin Young Kim, Jihye Kim
BACKGROUND: Microbial imbalance in the gut from antibiotic use may be an etiologic factor of Kawasaki disease (KD). We aimed to identify the association between the use of antibiotics and the development of KD, considering various antibiotic profiles. METHODS: A population-based, case-control study was performed using data from the Health Insurance Review and Assessment Service database. Children <5 years of age, who were diagnosed with KD between 2016 and 2019, were identified...
March 25, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38534044/effect-of-a-plant-protein-rich-diet-on-postprandial-phosphate-metabolism-in-healthy-adult-men-a-randomised-controlled-trial
#2
JOURNAL ARTICLE
Kozue Uenishi, Nozomi Kawasaki, Haruka Iseki, Misato Nogata, Yuki Kawabata, Shinsuke Kido
BACKGROUND: This study examined the effects of animal protein- and plant protein-rich diets on postprandial phosphorus metabolism in healthy male subjects. METHODS: The study was conducted by randomised parallel-group comparison of healthy men aged 21-24 years. In Study 1, participants were divided into two groups and consumed either a 70% animal protein diet (AD, n = 6) or a 70% plant protein diet (PD, n = 6). In Study 2, participants were divided into three groups and consumed either AD (n = 10), PD (n = 10) or AD + DF, a 70% animal protein diet loaded with the same amount of fibre as PD (n = 9)...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38532400/knowledge-attitudes-and-practices-towards-kawasaki-disease-from-caregivers-of-children-with-kawasaki-disease-a-cross-sectional-study
#3
JOURNAL ARTICLE
Miaomiao Zhao, Jiaxin Ye, Luping Chen, Yitong Yang, Meng Zhao, Mingzhu Yang, Zhaoling Shi
PURPOSE: To examine the knowledge, attitudes, and practices (KAP) of caregivers of children with Kawasaki disease toward Kawasaki disease. METHODS: This cross-sectional study was conducted at four hospitals in China from March 2023 to June 2023. The KAP scores were evaluated using a self-designed questionnaire (Cronbach's α = 0.840; KMO = 0.7381). Correlations between dimension scores were evaluated by Pearson correlation analysis...
March 26, 2024: BMC Public Health
https://read.qxmd.com/read/38524973/coronary-artery-aneurysms-following-repair-of-transposition-of-the-great-arteries
#4
Nikkan Das, Nazia Husain, Jyothy J Puthumana, Michael R Carr, Shivani G Patel
• Periodic surveillance after ASO for TGA with multimodality imaging is recommended. • New aneurysms may be detected in patients with antecedent KD. • KD should be suspected in patients with CAA even without previously known illness.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524885/primary-severe-pulmonary-and-tricuspid-valve-regurgitation-in-an-adult-patient
#5
Kazuki Yoshida, Haruka Sasaki, Hiroyuki Takaoka, Rei Hashimoto, Kenji Kawasaki, Goro Matsumiya, Kazuyuki Matsushita, Yoshio Kobayashi
• Severe progressive PR and TR in adults without histories of cardiac surgery is rare. • Carcinoid heart disease is an important differential in isolated PR and TR. • Three-dimensional TTE is helpful in identifying morphologic abnormalities of the PV. • CCT and cardiovascular magnetic resonance also help evaluate structures near the PV.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524347/ocular-nodular-fasciitis-in-kawasaki-disease
#6
JOURNAL ARTICLE
Sashwanthi Mohan, Madhuvanthi Mohan, Sujatha Mohan
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38521840/post-marketing-surveillance-of-the-safety-and-effectiveness-of-nivolumab-for-classic-hodgkin-lymphoma-in-japan
#7
JOURNAL ARTICLE
Akira Kawasaki, Kiyohiko Hatake, Itaru Matsumura, Koji Izutsu, Tomohiro Hoshino, Ayumi Akamatsu, Akito Kakuuchi, Kensei Tobinai
Nivolumab was approved for relapsed/refractory classic Hodgkin lymphoma (cHL) in Japan in 2016. After its approval, a prospective, non-interventional, observational post-marketing surveillance was initiated to evaluate the safety and effectiveness of nivolumab treatment for up to 12 months in patients with relapsed/refractory cHL. Of 304 registered patients, 288 were included in safety analyses and 282 in effectiveness analyses. There were 191 (66.3%) male patients, median age was 64.0 years, and 54 patients (18...
March 23, 2024: International Journal of Hematology
https://read.qxmd.com/read/38519783/prognostic-role-of-preoperative-chemotherapy-in-liver-limited-metastasis-from-gastric-cancer
#8
JOURNAL ARTICLE
Yuki Hirose, Masaki Aizawa, Hiroshi Yabusaki, Tatsuya Nomura, Kabuto Takano, Takashi Kawasaki, Gen Watanabe, Yukio Shimojima, Kizuki Yuza, Takeo Bamba, Satoru Nakagawa
BACKGROUND: We investigated the prognostic role of preoperative chemotherapy in patients who underwent hepatectomy for liver-limited metastasis (LLM) from gastric cancer (GC). METHODS: A retrospective analysis was conducted for 52 consecutive patients who underwent macroscopically complete (R0 or R1) resection for synchronous or metachronous LLM from GC. RESULTS: Of the 52 patients, 18 (35%) received preoperative chemotherapy (PC group), while 34 (65%) underwent upfront surgery (US group)...
March 22, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38516039/correlation-of-telomere-length-in-brain-tissue-with-peripheral-tissues-in-living-human-subjects
#9
JOURNAL ARTICLE
Annemarie J Carver, Benjamin Hing, Benjamin A Elser, Stephanie J Lussier, Takehiko Yamanashi, Matthew A Howard, Hiroto Kawasaki, Gen Shinozaki, Hanna E Stevens
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery ( n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38512940/accessible-luminal-interface-of-bovine-rectal-organoids-generated-from-cryopreserved-biopsy-tissues
#10
JOURNAL ARTICLE
Minae Kawasaki, Yoko M Ambrosini
Developing precise species-specific in vitro models that closely resemble in vivo intestinal tissues is essential for advancing our understanding of gastrointestinal physiology and associated diseases. This is especially crucial in examining host-pathogen interactions, particularly in bovines, a known reservoir for microbes and pathogens posing substantial public health threats. This research investigated the viability of producing bovine rectal organoids from cryopreserved tissues. We compared two cryopreservation methods with a traditional technique using fresh tissues, evaluating their effectiveness through growth rates, long-term viability, and comprehensive structural, cellular, and genetic analyses...
2024: PloS One
https://read.qxmd.com/read/38510083/case-report-identification-of-a-card8-variant-in-all-three-patients-with-pfapa-syndrome-complicated-with-kawasaki-disease
#11
Haruhiko Nakamura, Atsuo Kikuchi, Hideyuki Sakai, Miki Kamimura, Yohei Watanabe, Ryoichi Onuma, Jun Takayama, Gen Tamiya, Yoichi Mashimo, Ryota Ebata, Hiromichi Hamada, Tomohiro Suenaga, Yoshihiro Onouchi, Satoru Kumaki
BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in the immunopathogenesis of both diseases has been previously described. CASE PRESENTATION: Herein, we report the clinical courses of three patients who presented a rare combination of PFAPA syndrome and KD. Two patients who presented KD later developed the PFAPA syndrome, of whom one developed recurrent KD 2 years after the initial diagnosis...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38510081/cardiac-injury-progression-in-children-with-multisystem-inflammatory-syndrome-associated-with-sars-cov-2-infection-a-review
#12
REVIEW
Song Su, Wandong Hu, Xiao Chen, Ying Ren, Yi Lu, Jianguo Shi, Tong Zhang, Huan Zhang, Meng Wang, Yaping Wang, Fen Zhao, Ruifeng Jin, Yong Liu, Hongwei Zhang, Guohua Liu
The symptoms and signs of infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are milder in children than in adults. However, in April 2020, British pediatricians first reported that coronavirus disease 2019 (COVID-19) may present as multisystem inflammatory syndrome in children and adolescents (MIS-C), similar to that observed in Kawasaki disease. MIS-C can be associated with multiple systemic injuries and even death in children. In addition to digestive system involvement, cardiac injury is prominent...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38508571/different-dose-aspirin-plus-immunoglobulin-dapi-for-prevention-of-coronary-artery-abnormalities-in-kawasaki-disease-study-protocol-for-a-multi-centre-prospective-randomized-open-label-blinded-end-point-non-inferiority-trial
#13
JOURNAL ARTICLE
Yujian Wu, Lin Hu, Xiaofei Xie, Wei Li, Yanfei Wang, Li Zhang, Ping Huang, Fengxiang Li, Jianbin Li, Shuliang Xia, Jia Yuan, Ming Li, Zhouping Wang, Xu Zhang
BACKGROUND: Kawasaki disease is a pediatric acute systemic vasculitis that specifically involves the coronary arteries. Timely initiation of immunoglobulin plus aspirin is necessary for diminishing the incidence of coronary artery abnormalities (CAAs). The optimal dose of aspirin, however, remains controversial. The trial aims to evaluate if low-dose aspirin is non-inferior to moderate-dose in reducing the risk of CAAs during the initial treatment of Kawasaki disease. METHODS: This is a multi-centre, prospective, randomized, open-label, blinded endpoint, non-inferiority trial to be conducted in China...
March 18, 2024: American Heart Journal
https://read.qxmd.com/read/38498373/risk-of-diabetic-retinopathy-according-to-subtype-of-type-2-diabetes
#14
JOURNAL ARTICLE
Frederik N Pedersen, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Javad Hajari, Steffen Heegaard, Kurt Højlund, Ryo Kawasaki, Caroline S Laugesen, Sören Möller, Katja Schielke, Jens Steen Nielsen, Jacob V Stidsen, Reimar W Thomsen, Benjamin Thinggaard, Jakob Grauslund
Type 2 diabetes is a heterogeneous disease that can be subdivided based on beta-cell function and insulin sensitivity. We aimed to investigate the presence, incidence and progression of diabetic retinopathy (DR) according to subtypes of type 2 diabetes. In a national cohort, we identified three subtypes of type 2 diabetes which included classical, hyperinsulinemic and insulinopenic type 2 diabetes based on HOMA2 measurements. From the Danish Registry of Diabetic Retinopathy (DiaBase) we extracted information on level of DR...
March 18, 2024: Diabetes
https://read.qxmd.com/read/38497373/multisystem-inflammatory-syndrome-in-children-with-kawasaki-disease-like-manifestations-in-mma
#15
JOURNAL ARTICLE
Miao Huang, Xiyan Lu, Yongmei Zeng, Wujin Wang, Jiyong Zhang, Liting Wang, Guoqing Dong
Not required for Clinical Vignette.
March 18, 2024: Endokrynologia Polska
https://read.qxmd.com/read/38496479/plasma-cell-free-rna-signatures-of-inflammatory-syndromes-in-children
#16
Conor J Loy, Venice Servellita, Alicia Sotomayor-Gonzalez, Andrew Bliss, Joan Lenz, Emma Belcher, Will Suslovic, Jenny Nguyen, Meagan E Williams, Miriam Oseguera, Michael A Gardiner, Jong-Ha Choi, Hui-Mien Hsiao, Hao Wang, Jihoon Kim, Chisato Shimizu, Adriana Tremoulet, Meghan Delaney, Roberta L DeBiasi, Christina A Rostad, Jane C Burns, Charles Y Chiu, Iwijn De Vlaminck
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, including Kawasaki disease (KD), Multisystem Inflammatory Syndrome in Children (MIS-C), viral infections and bacterial infections...
March 8, 2024: medRxiv
https://read.qxmd.com/read/38496009/a-passage-free-simplified-and-scalable-novel-method-for-ipsc-generation-in-three-dimensional-culture
#17
JOURNAL ARTICLE
Masaya Tsukamoto, Tomoyuki Kawasaki, Mohan C Vemuri, Akihiro Umezawa, Hidenori Akutsu
Induced pluripotent stem cells (iPSCs) have immense potential for use in disease modeling, etiological studies, and drug discovery. However, the current workflow for iPSC generation and maintenance poses challenges particularly during the establishment phase when specialized skills are required. Although three-dimensional culture systems offer scalability for maintaining established iPSCs, the enzymatic dissociation step is complex and time-consuming. In this study, a novel approach was developed to address these challenges by enabling iPSC generation, maintenance, and differentiation without the need for two-dimensional culture or enzymatic dissociation...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38494057/replication-efficiency-of-sars-cov-2-omicron-subvariants-ba-2-75-ba-5-and-xbb-1-in-human-mini-gut-organoids
#18
JOURNAL ARTICLE
Kei Miyakawa, Masakazu Machida, Tomoyuki Kawasaki, Masatoshi Kakizaki, Yayoi Kimura, Masaya Sugiyama, Hideki Hasegawa, Akihiro Umezawa, Hidenori Akutsu, Akihide Ryo
No abstract text is available yet for this article.
March 15, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38493129/nlrc4-methylation-and-its-response-to-intravenous-immunoglobulin-therapy-in-kawasaki-disease-a-case-control-study
#19
JOURNAL ARTICLE
Beirong Yu, Bangxu Zheng, Yu Shen, Yijing Shen, Haiyan Qiu, Ling Wu, Yuanling Chen, Xiaohong Cai, Junhua Wu, Qingxiao Hong
BACKGROUND: Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain Containing 4 (NLRC4) encodes the key components of inflammasomes that function as pattern recognition receptors. The purpose of this study was to investigate the potential of NLRC4 methylation as a biomarker for KD. METHODS: In this study, pyrosequencing was utilized to analyze NLRC4 promoter methylation in blood samples from 44 children with initial complete KD and 51 matched healthy controls...
March 16, 2024: BMC Pediatrics
https://read.qxmd.com/read/38490013/parapharyngeal-and-retropharyngeal-infections-in-children-kawasaki-disease-needs-vigilance
#20
JOURNAL ARTICLE
Jia Liu, Shui-Hong Zhou
OBJECTIVE: Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options. METHODS: Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
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