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Kawasaki's disease

Ann W McMahon, Kevin Watt, Jian Wang, Dionna Green, Ram Tiwari, Gilbert J Burckart
BACKGROUND: Pediatric drug development is plagued by small sample sizes, unvalidated clinical endpoints, and limited studies. OBJECTIVES: The objective of this study was to determine whether age stratification within the pediatric population could be used to (1) assess response to a pharmacologic intervention and to (2) design future trials based upon published stratified disease data using clinical trial simulation (CTS). METHODS: Data available from the literature for Kawasaki disease (KD) was used in the model...
2016: Therapeutic Innovation & Regulatory Science
Sarah Parsons, Matthew Lynch
No abstract text is available yet for this article.
February 2016: Pathology
Elaheh Malakan Rad, Iran Malekzadeh, Vahid Ziaee, Raheleh Rajabi, Zohreh Shahabi
BACKGROUND: Kawasaki disease (KD) is the most common cause of acquired myocardial infarction in children. Coronary artery involvement is the most serious feature of this vasculitis syndrome. Timely diagnosis of coronary artery involvement is of utmost importance since it can prevent long-term morbidity and mortality. The current methods for the diagnosis of coronary artery dilation in KD are inconsistent and are also not capable of detecting all the abnormal coronary arteries or the so-called occult dilations present...
August 2016: Iranian Journal of Pediatrics
Caroline Barranco
No abstract text is available yet for this article.
October 20, 2016: Nature Reviews. Rheumatology
Iraj Mohammadzadeh, Somayyeh Noei, Kazem Babazadeh, Hassan Zamani, Rahim Barari-Savadkoohi, Reza Alizadeh-Navaei
BACKGROUND: Cardiac involvement was the major leading cause of death in patients with Kawasaki and IVIG administration reduces cardiac complications. The objective of this study was to determine the frequency of cardiovascular complications and duration of fever with regard to the time of intravenous immunoglobulin (IVIG) administration of patients with Kawasaki disease. METHODS: This follow-up study was done on all patients with Kawasaki disease who were hospitalized at Amirkola Children's Hospital between 2006 and 2011...
2016: Caspian Journal of Internal Medicine
Yoichiro Otaki, Tetsu Watanabe, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tsuneo Konta, Yoko Shibata, Hidenori Sato, Ryo Kawasaki, Makoto Daimon, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
BACKGROUND: Oxidative stress is a major cause of cardiovascular disease. Superoxide dismutase-1 (SOD1) is an antioxidant that protects against oxidative stress. Deoxyribonucleic acid (DNA) variations such as single nucleotide polymorphism (SNP) or haplotypes within the SOD gene are reportedly associated with the development of cardiovascular disease. However, it remains to be determined whether SOD1 variability is associated with cardiovascular or all-cause mortality in the general population...
2016: PloS One
Sandeep Hedgire, Benjamin Pulli, Manuella Lahoud-Rahme, Rebecca S Beroukhim, Ana M Rosales, Brian Ghoshhajra
No abstract text is available yet for this article.
October 14, 2016: Coronary Artery Disease
Shaojie Chen, Ying Dong, Marcio Galindo Kiuchi, Jiazhi Wang, Ruotian Li, Zhiyu Ling, Tingquan Zhou, Zhenglong Wang, Martin Martinek, Helmut Pürerfellner, Shaowen Liu, Mitchell W Krucoff
Importance: The timing and selection of patients with Kawasaki disease for corticosteroid use to prevent coronary artery complications remain controversial. Objective: To evaluate the effect of corticosteroid therapy in KD. Data Sources: Databases of Medline, The Cochrane Library, and the website until July 2015. We used the key words ["Kawasaki disease"] and ["steroid" OR "corticosteroid"] to retrieve potentially relevant studies in the databases of Medline, the Cochrane Library, and the Clinicaltrials...
October 17, 2016: JAMA Pediatrics
Robert Sundel
No abstract text is available yet for this article.
October 17, 2016: JAMA Pediatrics
Yoshiaki Okuma, Kenji Suda, Hideyuki Nakaoka, Yasuhiro Katsube, Yoshihide Mitani, Yukako Yoshikane, Fukiko Ichida, Takeji Matsushita, Hiroyuki Shichino, Isao Shiraishi, Jun Abe, Michiaki Hiroe, Toshimichi Yoshida, Kyoko Imanaka-Yoshida
BACKGROUND: Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is heavily upregulated at sites of inflammation. We conducted a retrospective study to assess the utility of TN-C as a novel biomarker to predict the risk of developing coronary artery lesions (CAL) and resistance to intravenous immunoglobulin (IVIG) in patients with Kawasaki disease (KD).Methods and Results:We collected blood samples of 111 KD patients (IVIG-responder: 89, IVIG-resistant: 22; CAL: 8) and 23 healthy controls, and measured the serum levels of TN-C...
October 15, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Mitsuaki Kimura, Masashi Harazaki, Tetsuya Fukuoka, Isao Asakura, Hidemasa Sakai, Tsutomu Kamimaki, Ichiro Ohkawara, Naoe Akiyama, Satoshi Tsurui, Satoru Iwashima, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro, Shiro Seto
BACKGROUND: Prednisolone (PSL) has been suggested to be useful for the treatment of patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). However, much remains to be elucidated regarding its proper use. METHODS: Two-stage multicenter prospective studies involving 1,087 subjects were performed to study the effects of acute phase therapy on IVIG-resistant KD. Subjects resistant to the first dose of IVIG were classified into high (≥ 10 mg/dL) and low (< 10 mg/dL) CRP groups according to serum CRP levels after the first dose of IVIG...
October 15, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Walter R Wilson, Thomas C Bower, Mark A Creager, Sepideh Amin-Hanjani, Patrick T O'Gara, Peter B Lockhart, Rabih O Darouiche, Basel Ramlawi, Colin P Derdeyn, Ann F Bolger, Matthew E Levison, Kathryn A Taubert, Robert S Baltimore, Larry M Baddour
No abstract text is available yet for this article.
October 13, 2016: Circulation
Kimura Teruo, Adam Tucker, Toshihide Sugimura, Toshitaka Seki, Shin Fukuda, Satoru Takeuchi, Shiro Miyata, Tsutomu Fujita, Akira Hashizume, Naoto Izumi, Kazutsune Kawasaki, Makoto Katsuno, Masaaki Hashimoto, Kazuhiro Sako
BACKGROUND AND PURPOSE: The optimal use of antiplatelet therapy for intracranial branch atheromatous disease (BAD) is not known. METHODS: We conducted a prospective multicenter, single-group trial of 144 consecutive patients diagnosed with probable BAD. All patients were treated within 12 h of symptom onset to prevent clinical progression using dual antiplatelet therapy with cilostazol plus one oral antiplatelet drug (aspirin or clopidogrel). Endpoints of progressive BAD in the dual therapy group at 2 weeks were compared with a matched historical control group of 142 patients treated with single oral antiplatelet therapy using either cilostazol, aspirin, or clopidogrel...
October 12, 2016: Cerebrovascular Diseases Extra
Robert Sabiniewicz, Lidia Woźniak, Maksymilian Mielczarek, Dariusz Ciećwierz, Rafał Pawlaczyk
No abstract text is available yet for this article.
2016: Cardiology Journal
Mirinae Jang, Min Su Oh, Se Cheol Oh, Ki Soo Kang
Although liver function test abnormality is frequently noted in children, there is no report about the distribution of the etiology and natural recovery time of the abnormal liver function. From March 2005 to February 2014, clinical information was retrospectively collected from 559 children who had abnormal liver function and were hospitalized or visited the outpatient clinic at the Jeju National University Hospital. The etiology of abnormal liver function was classified into groups and the natural recovery time of abnormal liver function was analyzed...
November 2016: Journal of Korean Medical Science
Raymond M Johnson, Kelly R Bergmann, John J Manaloor, Xiaoqing Yu, James E Slaven, Anupam B Kharbanda
Background.  Pediatric Kawasaki disease (KD) and human immunodeficiency virus (HIV)(+) adult Kawasaki-like syndrome (KLS) are dramatic vasculitides with similar physical findings. Both syndromes include unusual arterial histopathology with immunoglobulin (Ig)A(+) plasma cells, and both impressively respond to pooled Ig therapy. Their distinctive presentations, histopathology, and therapeutic response suggest a common etiology. Because blood is in immediate contact with inflamed arteries, we investigated whether KD and KLS share an inflammatory signature in serum...
September 2016: Open Forum Infectious Diseases
Magali Noval Rivas, Youngho Lee, Daiko Wakita, Norika Chiba, Jargalsaikhan Dagvadorj, Kenichi Shimada, Shuang Chen, Michael C Fishbein, Thomas J A Lehman, Timothy R Crother, Moshe Arditi
OBJECTIVE: Kawasaki disease (KD) is the leading cause of acquired heart disease among children in developed countries. Human KD coronary lesions are characterized by increased presence of infiltrating CD3(+) T cells, however the specific contributions of the different T cell subpopulations in coronary arteritis development remains unknown. Therefore, we sought to investigate the function of CD4(+) , CD8(+) , Regulatory T cells (TReg ), and NK T cells in the pathogenesis of the KD. METHODS AND RESULTS: T cell subsets function in KD development was addressed by using a well-established murine model of Lactobacillus casei cell wall extract (LCWE)-induced KD vasculitis...
October 1, 2016: Arthritis & Rheumatology
Martin Prince Alphonse, Trang T Duong, Chisato Shumitzu, Truong Long Hoang, Brian W McCrindle, Alessandra Franco, Stéphane Schurmans, Dana J Philpott, Martin L Hibberd, Jane Burns, Taco W Kuijpers, Rae S M Yeung
Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point to the potential role of inflammasome activation in KD. Mutations in NLRP3 are associated with recurrent fever/autoinflammatory syndromes. We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1β and IL-18...
September 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Shunsuke Sekiya, Makoto Murata, Satoshi Arai, Hiroshi Murayama, Atushi Kawasaki, Noriyuki Ashida, Kohki Okada, Masaki Ikemoto
Calprotectin, a heterodimer of S100A8 and S100A9, has been reported to be a useful biomarker in inflammatory bowel disease (IBD); however, the relationship between the fecal level of S100A9 and the extent of inflammation in IBD remains unclear. Our aim was to develop a new enzyme-linked immunosorbent assay (ELISA) for rat S100A9, and to investigate whether changes in fecal S100A9 levels reflect the inflammatory conditions in the intestinal tracts of rats with dextran sulfate sodium (DSS)-induced colitis. Anti-rat S100A9 monoclonal antibodies were raised in mice and used for the development of a novel ELISA for rat S100A9...
September 28, 2016: Journal of Immunological Methods
Kazuhiro Kobayashi, Toshihiro Saito, Yasuo Kitamura, Vladimir Bilim, Tomotaka Toba, Takashi Kawasaki, Noboru Hara, Toshiki Tanikawa, Yoshihiko Tomita
OBJECTIVES: To characterize patients experiencing late recurrence after primary radical surgery for renal cell carcinoma and to approach the mechanism of late recurrence. METHODS: We retrospectively analyzed 657 consecutive patients who underwent radical surgery for pathologically confirmed ≤stage III renal cell carcinoma in a single institution between January 1981 and December 2008. Early or late recurrence was defined as a recurrence occurring before or after 60 months after primary surgery...
February 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
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