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Kawasaki's disease

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https://www.readbyqxmd.com/read/29239297/dynamic-flow-imaging-using-320-detector-row-ct-and-motion-coherence-analysis-in-coronary-aneurysms-associated-with-kawasaki-disease
#1
Yamato Shimomiya, Michinobu Nagao, Yuzo Yamasaki, Takashi Shirasaka, Masatoshi Kondo, Tsukasa Kojima, Akihiro Nishie, Kenichiro Yamamura, Hiroshi Honda
Introduction We propose a new dynamic flow imaging using 320-detector row CT, and investigate the assessment of coronary flow in aneurysms of Kawasaki disease in adulthood. METHODS: Six patients with Kawasaki disease and coronary aneurysms associated (26.7 years old) and six controls were enrolled. Dynamic coronary CT angiography with 320-row CT was continuously performed at mid-diastole throughout 15-25 cardiac cycles with prospective Electrocardiogram gating after injection of contrast media...
December 14, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29239028/recovery-of-myocardial-mechanics-in-kawasaki-disease-demonstrated-by-speckle-tracking-and-tissue-doppler-methods
#2
Emine Azak, Ibrahim Ilker Cetin, Hazım A Gursu, Ayse Esin Kibar, Murat Surucu, Ali Orgun, Utku Pamuk
AIM: To investigate myocardial deformation and function during treatment for Kawasaki disease (KD) in children. METHODS: We performed speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI) in 15 children with KD and 15 healthy children during treatment for KD. STE was performed for longitudinal and circumferential strain (S) and strain rate (SR) at the left ventricle (LV) and for longitudinal S and SR at the right ventricle (RV). TDI was performed at the base of interventricular septum (IVS), LV, and RV...
December 13, 2017: Echocardiography
https://www.readbyqxmd.com/read/29238020/-prolonged-optic-disc-swelling-in-kawasaki-disease-a-case-report-and-literature-review
#3
Yusuke Tsumura, Hiroshi Masuda, Sachiko Nishina, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Jun Abe, Akira Ishiguro
  Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred to us from the ophthalmology department due to injected bulbar conjunctivae and optic disc swelling. She had familial exudative vitreoretinopathy as an underlying disease and the ocular findings had been made by chance while the patient was receiving an eye examination...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29233459/invasive-meningococcal-disease-due-to-ciprofloxacin-resistant-neisseria-meningitidis-sequence-type-4821-the-first-case-in-japan
#4
Yu Kawasaki, Kousaku Matsubara, Hideyuki Takahashi, Masatomo Morita, Makoto Ohnishi, Masayuki Hori, Kenichi Isome, Aya Iwata, Hiroyuki Nigami, Mami Ikemachi, Go Yamamoto, Kiyofumi Ohkusu
We present a 4-year-old girl who developed invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup C sequence type (ST)-4821. She was hospitalized due to fever, vomiting, rash and altered consciousness. Serogroup C N. meningitidis was isolated from blood culture taken on admission and was confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a biochemical test, and molecular microbiological analysis. The patient was successfully treated with 50 mg/kg ceftriaxone every 12 hours for 7 days without any complications...
December 7, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#5
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29229480/liver-transplantation-for-deterioration-in-native-liver-function-after-portoenterostomy-for-biliary-atresia-in-japan-short-versus-long-term-survivors
#6
Takanori Ochi, Hiroki Nakamura, Momoko Wada, Tsuyoshi Tamura, Hiroyuki Koga, Tadaharu Okazaki, Masahiko Urao, Yoichi Ishizaki, Seiji Kawasaki, Mureo Kasahara, Koichi Mizuta, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: We reviewed our post-Kasai portoenterostomy biliary atresia (BA) patients who required liver transplantation (LTx) for deterioration in native liver (NL) function to investigate mortality in relation to age at LTx. METHODS: BA patients indicated for LTx when less than 18years old (U18; n=17) and when 18 or older (18+; n=13) were compared. All achieved jaundice clearance postoperatively (TBil ≤1.2mg/dL (≈20μmol/L)). RESULTS: In U18, living-donor (LD) LTxs were performed at a median of 6...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29224935/infliximab-for-the-treatment-of-refractory-kawasaki-disease-a-nationwide-survey-in-japan
#7
Hiroshi Masuda, Tohru Kobayashi, Akira Hachiya, Yasutaka Nakashima, Hiroyuki Shimizu, Tomo Nozawa, Yoshihito Ogihara, Shuichi Ito, Shinichi Takatsuki, Nobuyuki Katsumata, Yasuo Suzuki, Satoshi Takenaka, Keiichi Hirono, Tomio Kobayashi, Hiroshi Suzuki, Eisuke Suganuma, Kei Takahashi, Tsutomu Saji
OBJECTIVE: To assess the safety and efficacy of infliximab (IFX) for the treatment of patients with Kawasaki disease (KD). STUDY DESIGN: This was a nationwide survey of 274 Japanese institutions exploring how IFX was used to treat patients with KD. The patients' sex, age, treatment course, pre- and post-IFX therapy blood test results, coronary artery lesions (CALs), and adverse events (AEs) were evaluated. RESULTS: We analyzed 434 patients with KD who received IFX between March 2005 and November 2014...
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29220406/excessively-low-salt-diet-damages-the-heart-through-activation-of-cardiac-pro-renin-receptor-renin-angiotensin-aldosterone-and-sympatho-adrenal-systems-in-spontaneously-hypertensive-rats
#8
Chihiro Okamoto, Yuka Hayakawa, Takuma Aoyama, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Shinya Minatoguchi
OBJECTIVE: A high salt intake causes hypertension and leads to cardiovascular disease. Therefore, a low salt diet is now recommended to prevent hypertension and cardiovascular disease. However, it is still unknown whether an excessively low salt diet is beneficial or harmful for the heart. METHODS: Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) received normal salt chow (0.9% salt diet) and excessively low salt chow (0.01% salt diet referred to as saltless diet) for 8 weeks from 8 to 16 weeks of age...
2017: PloS One
https://www.readbyqxmd.com/read/29219653/characteristics-and-outcome-of-intractable-vasculitis-syndrome-in-children-nation-wide-survey-in-japan
#9
Naoko Nakano, Masaaki Mori, Hiroaki Umebayashi, Naomi Iwata, Norimoto Kobayashi, Kenji Masunaga, Tomoyuki Imagawa, Takuji Murata, Noriko Kinjo, Kazushige Nagai, Mari Miyoshi, Syuji Takei, Shumpei Yokota, Eiichi Ishii
OBJECTIVE: Primary systemic vasculitis (PSV) is a rare disorder in children and difficult to distinguish from other diseases. However, appropriate diagnosis and prompt treatment will affect on the morbidity and mortality of intractable PSV. In this study, we conducted a nationwide survey in Japan, to clarify epidemiology and clinical outcome of PSV. METHODS: We had sent survey questionnaires to most of the Japanese institutions that employed pediatricians, requesting the number of patients with refractory PSV who were diagnosed and treated between 2007 and 2011...
December 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29215541/pancreatic-insufficiency-in-cystic-fibrosis-influence-of-inflammatory-response-genes
#10
Fernando Augusto Lima Marson, Carmen Sílvia Bertuzzo, Tânia Kawasaki de Araujo, Taís Daiene Russo Hortencio, Antônio Fernando Ribeiro, José Dirceu Ribeiro
OBJECTIVE: Pancreatic insufficiency (PI) in cystic fibrosis (CF) patients is a crucial clinical marker for severity and disease progression. In our study, 125 modifier genes and their SNPs were associated between CF patients with PI or pancreatic sufficiency. METHODS: We prospectively evaluated 214 CF patients admitted at 1 hospital for a 2-year period. The PI status was associated with clinical variables and SNPs related with inflammatory response considering CFTR mutations...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29214786/itpkc-and-slc11a1-gene-polymorphisms-and-gene-gene-interactions-in-korean-patients-with-kawasaki-disease
#11
Kyu Yeun Kim, Yoon Sun Bae, Woohyuk Ji, Dongjik Shin, Ho Seong Kim, Dong Soo Kim
PURPOSE: Kawasaki disease (KD) is an acute systemic vasculitis. Both the etiology of KD and the erythema of Bacille Calmette-Guérin (BCG) injection sites observed in the disease are poorly understood. We investigated the association between KD and single nucleotide polymorphisms (SNPs) in two candidate genes: inositol 1,4,5-triphosphate 3-kinase (ITPKC), a well-studied KD-associated gene, and solute carrier 11a1 (SLC11A1), which is associated with the hypersensitive reaction to the BCG strain in Koreans...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214785/clinical-outcomes-of-low-dose-methotrexate-therapy-as-a-second-line-drug-for-intravenous-immunoglobulin-resistant-kawasaki-disease
#12
Hyejin Jang, Kyu Yeun Kim, Dong Soo Kim
PURPOSE: Intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD). However, there is still no standard treatment for IVIG-resistant KD. This study aimed to evaluate the efficacy of low-dose methotrexate (MTX) as a treatment for IVIG-resistant KD. MATERIALS AND METHODS: We retrospectively analyzed 10-year data for patients with IVIG-resistant KD who were administered MTX at Severance Children's Hospital. RESULTS: The subjects included 75 patients with KD aged 5 months to 9...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214375/review-surgical-treatment-of-giant-coronary-aneurysms-in-pediatric-patients-with-kawasaki-disease
#13
Masami Ochi
In Kawasaki disease (KD), giant coronary aneurysms in the proximal segments of the coronary arteries have long been among the serious complications associated with acute myocardial infarction. To treat myocardial ischemia in children, Kitamura et al. first performed coronary artery bypass grafting in a pediatric patient using an autologous saphenous vein. In the early 1980s, they began to use the internal thoracic artery (ITA) as a bypass graft to the left anterior descending artery, which later was proven to improve long-term life expectancy with its favorable long-term patency, as well as growth potential...
December 6, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29212623/intrauterine-and-early-postnatal-exposure-to-particulate-air-pollution-and-kawasaki-disease-a-nationwide-longitudinal-survey-in-japan
#14
Takashi Yorifuji, Hirokazu Tsukahara, Saori Kashima, Hiroyuki Doi
OBJECTIVES: To examine the effects of prenatal and postnatal exposure to particulate matter on Kawasaki disease (KD) occurrence, using data from a nationwide population-based longitudinal survey in Japan that began in 2010. STUDY DESIGN: Prenatal and postnatal suspended particulate matter concentrations were obtained at municipality level and assigned to participants based on their municipality of birth. We analyzed data from 30 367 participants with data on either exposure period...
December 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29212621/stenotic-lesions-and-the-maximum-diameter-of-coronary-artery-aneurysms-in-kawasaki-disease
#15
Etsuko Tsuda, Nobuyuki Tsujii, Yohsuke Hayama
OBJECTIVES: To determine the prevalence of subsequent stenotic lesions based on the maximum diameter of the largest coronary artery aneurysm in patients with Kawasaki disease and the threshold value of coronary artery diameter associated with risk of developing stenotic lesion. STUDY DESIGN: There were 214 patients (160 males) who had at least 1 aneurysm in a selective coronary angiogram (CAG) done <100 days after the onset of Kawasaki disease were studied. We measured the maximal coronary artery aneurysm diameter in 3 major branches in the initial CAGs...
December 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29208331/autoimmune-and-medication-induced-lymphadenopathies
#16
REVIEW
Alejandro A Gru, Dennis P O'Malley, Aliso Viejo
This article will provide a discussion of some common autoimmune disorders that could affect the lymph nodes and potentially mimic B and T-cell lymphomas. Some of these disorders are more characteristic of individuals in the pediatric age group (autoimmune lymphoproliferative syndrome, Kawasaki disease), while others present in older individuals (rheumatoid arthritis, lupus erythematosus, sarcoidosis). A common finding that groups all of these disorders together is the overall relative preservation of the architecture, a feature that can be particularly helpful to distinguish them from many B and T-cell lymphomas...
November 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29207369/young-athlete-with-complex-aneurysmal-coronary-stenosis
#17
Eric P Stahl, Farshad Forouzandeh, Brent P Little, Habib Samady
Kawasaki disease is an acute vasculitis that occurs predominantly in infants and children younger than 5 years old. If undiagnosed and untreated, the risk of developing coronary artery aneurysms increases to about 20%. In patients who present with angina and are found to have coronary artery aneurysm on imaging and angiography, Kawasaki disease should be considered as one of the leading diagnoses.
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29207079/molecular-basis-of-coronary-artery-dilation-and-aneurysms-in-patients-with-kawasaki-disease-based-on-differential-protein-expression
#18
Wanting Liu, Chaowu Liu, Li Zhang, Xiaofei Xie, Xiaoqiong Gu, Chuanlan Sang, Mingguo Xu, Weijun Xu, Hongling Jia
Kawasaki disease (KD) is an acquired cardiac disease with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and coronary artery aneurysms (CAA). The identification of differentially expressed proteins and the underlying mechanisms may be the key to understanding differences between these KD complications. In the present study, isobaric tags for relative and absolute quantitation were used to identify variations in serum proteins between KD patients with CAD and CAA...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205910/role-of-intravenous-immunoglobulin-in-the-treatment-of-kawasaki-disease
#19
Mindy S Lo, Jane W Newburger
Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably given during the first 10 days of illness. In this review, we have discussed the possible mechanisms of action of IVIg in KD and its clinical usage in this condition.
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29203262/computed-tomography-coronary-angiography-for-evaluation-of-children-with-kawasaki-disease
#20
Manphool Singhal, Surjit Singh, Pankaj Gupta, Avinash Sharma, Niranjan Khandelwal, Jane C Burns
OBJECTIVE: We sought to assess the feasibility of computed tomography coronary angiography (CTCA) on a 128-slice, dual source scanner in children with acute and convalescent phase Kawasaki disease (KD). MATERIALS AND METHODS: A prospective study of 49 children with KD (12 at presentation and 37 in the convalescent phase) was conducted between November 2013 and April 2015. CTCA was performed with either prospective (n = 37) or retrospective (n = 12) electrocardiographic gating...
October 23, 2017: Current Problems in Diagnostic Radiology
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