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Endometrial receptivity

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https://www.readbyqxmd.com/read/28441042/aberrantly-expressed-long-noncoding-rnas-in-recurrent-implantation-failure-a-microarray-related-study
#1
Li-Juan Fan, Hong-Jing Han, Jing Guan, Xiao-Wei Zhang, Qing-Hua Cui, Huan Shen, Cheng Shi
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs longer than 200 nucleotides. They were long regarded as transcription noise for their low expression and non-protein coding features. Recent published reports indicate that lncRNAs are involved in virtually every aspect of human biology. We aimed to profile the endometrial lncRNA expression pattern in women with recurrent implantation failure (RIF) and predict the function of the genes of the dysregulated lncRNA transcripts. Endometrial samples (24) were collected during window of implantation (14 RIF women and 10 women who conceived after embryo transfer)...
April 25, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28436055/implantation-window-and-angiogenesis
#2
Mostafa Peyvandi Karizbodagh, Bahman Rashidi, Amirhossein Sahebkar, Aria Masoudifar, Hamed Mirzaei
In recent decades, infertility is one of the health problems worldwide. One of the most crucial events in reproductive period is implantation window (IW). In the time after IW period, the embryo cannot connect to the endometrium; therefore the most critical issue for successful implantation is timely entrance of embryo to the uterine cavity during the IW. Implantation failure is responsible for many cases of infertility and is the most important limiting factor for achieving a successful outcome using the assisted reproductive techniques (ART)...
April 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28426261/a-morphological-study-of-uterine-alterations-in-mice-due-to-exposure-to-cadmium
#3
M Sapmaz-Metin, Y Topcu-Tarladacalisir, I Kurt-Omurlu, B Karaoz Weller, S Unsal-Atan
We investigated the morphologic and molecular effects of exposure to cadmium (Cd) for 30 and 60 days on the uteri of mice. We assessed uterine morphometric measurements, eosinophilia, mast cell numbers, endometrial apoptosis, proliferation and estrogen receptor alpha (ERα) immunoreactivity. We examined vaginal smears that reflected the hormonal alterations in the female reproductive tract. Because the female reproductive tract exhibits different morphology at each stage of the estrous cycle, we sacrificed all animals at estrus to make appropriate comparisons...
April 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28424251/nuclear-shp2-directs-normal-embryo-implantation-via-facilitating-the-er%C3%AE-tyrosine-phosphorylation-by-the-src-kinase
#4
Hao Ran, Shuangbo Kong, Shuang Zhang, Jianghong Cheng, Chan Zhou, Bo He, Qiliang Xin, John P Lydon, Francesco J DeMayo, Gen-Sheng Feng, Guoliang Xia, Zhongxian Lu, Chao Wang, Haibin Wang
Estrogen and progesterone coupled with locally produced signaling molecules are essential for embryo implantation. However, the hierarchical landscape of the molecular pathways that governs this process remains largely unexplored. Here we show that the protein tyrosine phosphatase Shp2, a positive transducer of RTK signaling, is predominately localized in the nuclei in the periimplantation mouse uterus. Uterine-specific deletion of Shp2 exhibits reduced progesterone receptor (PR) expression and progesterone resistance, which derails normal uterine receptivity, leading to complete implantation failure in mice...
April 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28398477/elective-embryo-transfers-on-day-6-reduce-implantation-compared-with-transfers-on-day-5
#5
V Poulsen, H J Ingerslev, K Kirkegaard
STUDY QUESTION: Is there a difference in pregnancy rates between embryos transferred electively on Day 5 and Day 6, respectively? SUMMARY ANSWER: The chance of pregnancy is significantly reduced (odds ratio (OR): 0.34; 95% CI 0.22-0.52) if transfer is performed on Day 6 compared with Day 5. WHAT IS KNOWN ALREADY: Several studies report that Day 5 transfers have higher implantation rates (IRs) when compared with Day 6 transfers. These studies were based on non-elective Day 6 transfers, where transfers on Day 6 were performed with developmentally delayed embryos...
April 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28395321/comprehensive-rna-sequencing-of-healthy-human-endometrium-at-two-time-points-of-the-menstrual-cycle%C3%A2
#6
Benjamin Sigurgeirsson, Hanna Åmark, Anders Jemt, Dorina Ujvari, Magnus Westgren, Joakim Lundeberg, Sebastian Gidlöf
Endometrial receptivity is crucial for implantation and establishment of a normal pregnancy. The shift from proliferative to receptive endometrium is still far from being understood. In this paper, we comprehensively present the transcriptome of the human endometrium by comparing endometrial biopsies from proliferative phase with consecutive biopsies 7-9 days after ovulation. The results show a clear difference in expression between the two time points using both total and small RNA sequencing. A total of 3,297 messenger RNAs (mRNAs), 516 long noncoding RNAs (lncRNAs), and 102 small noncoding RNAs were identified as statistically differentially expressed between the two time points...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28370781/downregulation-of-genes-related-to-immune-and-inflammatory-response-in-ivf-implantation-failure-cases-under-controlled-ovarian-stimulation
#7
Amruta D S Pathare, Kusum Zaveri, Indira Hinduja
PROBLEM: Implantation failure (IF) even after the good-quality embryo transfer (ET) is main obstacle in in vitro fertilization (IVF). We aim to study the genomics of endometrial receptivity in IF patients under controlled ovarian stimulation (COS) during which ET is generally practised in IVF. METHOD OF STUDY: Endometrial gene expression profiling in IF patients (n=10) and oocyte donors (n=8) were compared during window of implantation under COS by microarray. Enrichment analysis of microarray data was performed to determine dysregulated pathways...
March 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28368537/tissue-specific-ablation-of-the-lif-receptor-in-the-murine-uterine-epithelium-results-in-implantation-failure
#8
JrGang Cheng, Gracy Rosario, Tatiana V Cohen, Jianbo Hu, Colin L Stewart
The cytokine Leukemia inhibitory factor (LIF) is essential for rendering the uterus receptive for blastocyst implantation. In mice LIF receptor expression (LIFR) is largely restricted to the uterine luminal epithelium (LE). LIF, secreted from the endometrial glands (GE) binds to the LIFR, activating the Jak-Stat3 signaling pathway in the LE. JAK-STAT activation converts the LE to a receptive state so that juxtaposed blastocysts begin to implant. To specifically delete the LIFR in the LE we derived a line of mice in which Cre recombinase was inserted into the endogenous Lactoferrin gene (Ltf-Cre)...
March 22, 2017: Endocrinology
https://www.readbyqxmd.com/read/28333280/hcg-activates-the-erk1-2-mitogen-activated-protein-kinase-pathway-in-human-endometrial-stromal-cells-transiently-increasing-the-progesterone-receptor-and-regulating-genes-associated-with-endometrial-receptivity
#9
Alejandro Tapia-Pizarro, Sebastián Archiles, Felipe Argandoña, Cecilia Valencia, Keyla Zavaleta, María Cecilia Johnson, Reinaldo González-Ramos, Luigi Devoto
STUDY QUESTION: How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? SUMMARY ANSWER: CG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cAMP (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function. WHAT IS KNOWN ALREADY: hCG is one of the earliest embryo-derived secreted signals in the endometrium, which abundantly expresses LH/hCG receptors...
March 14, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333033/freeze-all-cycle-in-reproductive-medicine-current-perspectives
#10
Matheus Roque, Marcello Valle, Alessandra Kostolias, Marcos Sampaio, Selmo Geber
The freeze-all strategy has emerged as an alternative to fresh embryo transfer (ET) during in vitro fertilization (IVF) cycles. Although fresh ET is the norm during assisted reproductive therapies (ART), there are many concerns about the possible adverse effects of controlled ovarian stimulation (COS) over the endometrium. The supra-physiologic hormonal levels that occur during a conventional COS are associated with modifications in the peri-implantation endometrium, which may be related to a decrease in pregnancy rates and poorer obstetric and perinatal outcomes when comparing fresh to frozen-thawed embryo transfers...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28324064/bmp7-induces-uterine-receptivity-and-blastocyst-attachment
#11
Diana Monsivais, Caterina Clementi, Jia Peng, Paul T Fullerton, Renata Prunskaite-Hyyryläinen, Seppo J Vainio, Martin M Matzuk
In women, the window of implantation is limited to a brief 2- to 3-day period characterized by optimal levels of circulating ovarian hormones and a receptive endometrium. Although the window of implantation is assumed to occur 8 to 10 days after ovulation in women, molecular markers of endometrial receptivity are necessary to determine optimal timing prior to embryo transfer. Previous studies showed that members of the bone morphogenetic protein (BMP) family are expressed in the uterus necessary for female fertility; however, the role of BMP7 during implantation and in late gestation is not known...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322538/controlled-ovarian-stimulation-and-triggers-in-in-vitro-fertilization-protocol-personalization-key-to-optimize-outcomes
#12
Jacqueline Y Maher, Mindy S Christianson
The past four decades have delivered many advancements to improve in vitro fertilization (IVF) outcomes. These include a delicate balance of controlled ovarian hyperstimulation (COH) without causing ovarian hyperstimulation syndrome (OHSS), a safe oocyte retrieval, fertilization and embryo culture, endometrial growth and receptivity to promote implantation, and luteal support to maintain the pregnancy. Contemporary IVF practice includes both the classic COH protocols as well as protocols for poor responders and those for specific patient populations...
March 21, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28293067/syndecan-1-acts-as-an-important-regulator-of-cxcl1-expression-and-cellular-interaction-of-human-endometrial-stromal-and-trophoblast-cells
#13
Dunja Maria Baston-Buest, Olga Altergot-Ahmad, Sarah Jean Pour, Jan-Steffen Krüssel, Udo Rudolf Markert, Tanja Natascha Fehm, Alexandra Petra Bielfeld
Successful implantation of the embryo into the human receptive endometrium is substantial for the establishment of a healthy pregnancy. This study focusses on the role of Syndecan-1 at the embryo-maternal interface, the multitasking coreceptor influencing ligand concentration, release and receptor presentation, and cellular morphology. CXC motif ligand 1, being involved in chemotaxis and angiogenesis during implantation, is of special interest as a ligand of Syndecan-1. Human endometrial stromal cells with and without Syndecan-1 knock-down were decidualized and treated with specific inhibitors to evaluate signaling pathways regulating CXC ligand 1 expression...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28285568/cigarette-smoking-affects-uterine-receptivity-markers
#14
Gulcin Sahin Ersoy, Yuping Zhou, Hamdi İnan, Cuneyt E Taner, Emine Cosar, Hugh S Taylor
OBJECTIVE: Smoking negatively affects fertility and the rate of other endometrial diseases. To determine the effect of smoking on endometrial physiology, we evaluated 2 endometrial regulatory cytokines and receptivity markers, C-X-C motif chemokine ligand 12 (CXCL12) and fibroblast growth factor 2 (FGF2), both in vitro and in vivo. STUDY DESIGN: The human endometrial stromal cell line (HESC) and primary human endometrial stromal cells were treated with cigarette smoking extract (CSE) or with vehicle control...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28284179/research-on-the-expression-of-integrin-%C3%AE-3-and-leukaemia-inhibitory-factor-in-the-decidua-of-women-with-cesarean-scar-pregnancy
#15
Zhi-Da Qian, Yue Weng, Chun-Fen Wang, Li-Li Huang, Xiao-Ming Zhu
BACKGROUND: Cesarean scar pregnancy (CSP) is a late serious complication of cesarean section. There has been an increase in the incidence of CSP worldwide in recent years. It's a life-threatening condition because of the high risk of uncontrolled hemorrhage and uterine rupture. The mechanism of CSP is still unclear. The endometrial receptivity might be different in the cesarean scar between CSP and normal pregnancies. Endometrial expression of integrin β3 and LIF positively correlates with endometrial receptivity and embryo implantation...
March 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28284038/3d-and-4d-studies-from-human-reproduction-to-perinatal-medicine
#16
Sonal Panchal, Asim Kurjak, Chaitanya Nagori
Three-dimensional ultrasound (3D US) is a modality of choice for prenatal diagnosis of congenital malformations. But 3D-four-dimensional US(4D US) is of utmost importance also to achieve pregnancy. 3D US plays an important role for diagnosis of PCO, to assess ovarian reserve and response and thus to decide optimum stimulation protocols. It adds to the information on follicular maturity and endometrial receptivity, thus improving the chances to achieve pregnancy for patients under treatment for fertility. 3D hystero-contrast-salpingography (HyCoSy) has also proved itself to be one of the best modalities for assessment of tubal patency...
March 11, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28283674/endometrial-transcriptome-in-recurrent-miscarriage-and-recurrent-implantation-failure
#17
Jin Huang, Hao Qin, Yihua Yang, Xiaoyan Chen, Jiamiao Zhang, Susan Laird, Chi Chiu Wang, Ting Fung Chan, Tin Chiu Li
The endometrium becomes receptive to the embryo only in the mid-luteal phase, but not other stages of the menstrual cycle. Endometrial factors play an important role in implantation. Women with recurrent miscarriage and recurrent implantation failure have both been reported to have altered expression of receptivity markers during the window of implantation. We aimed to compare the gene expression profiles of the endometrium in the window of implantation among women with unexplained recurrent implantation failures (RIF) and unexplained recurrent miscarriages (RM) by RNA sequencing (RNA-Seq)...
March 10, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28280798/endometrial-expression-of-%C3%AE-3-integrin-calcitonin-and-plexin-b1-in-the-window-of-implantation-in-women-with-unexplained-infertility
#18
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Nahid Shahbazian, Maryam Mirani
BACKGROUND: Endometrial receptivity plays a key role in the establishment of successful implantation and its impairment may contribute to subfertility and limit the assisted reproduction techniques (ART) success. OBJECTIVE: The aim of present study was to investigate endometrial receptivity in terms of β3 integrin, calcitonin and plexin-B1 expression in women with unexplained infertility. MATERIALS AND METHODS: We evaluated expression of β3 integrin, calcitonin and plexin-B1 through mRNA level measurement with real-time RT-PCR, in the endometrium of 16 infertile women with unexplained infertility and 10 fertile women...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28277118/prostaglandin-e2-promotes-bewo-spheroids-implantation-in-rl95-2-cell-monolayers
#19
Xiaman Huang, Haizhi Liu, Ruiman Li
PURPOSE: Integrin αvβ3 (ITG αvβ3) participates in the process of implantation between the embryo and the endometrium. This study investigated the effects of prostaglandin E2 (PGE2) on endometrial receptivity and implantation efficiency of the embryo, and their possible mechanisms. METHODS: Quantitative real-time reverse transcription PCR (qRT-PCR) and western blotting were used to detect the changes in mRNA and protein levels of ITG αvβ3 in RL95-2 cells after administering PGE2...
March 1, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28242961/endometrial-polyps-and-subfertility
#20
REVIEW
Ali Al Chami, Ertan Saridogan
Endometrial polyps are frequently seen in subfertile women, and there is some evidence suggesting a detrimental effect on fertility. How polyps contribute to subfertility and pregnancy loss is uncertain and possible mechanisms are poorly understood. It may be related to mechanical interference with sperm transport, embryo implantation or through intrauterine inflammation or altered production of endometrial receptivity factors. Different diagnostic modalities such as two- or three-dimensional transvaginal ultrasound, saline infusion sonography or hysteroscopy are commonly used to evaluate endometrial polyps with good detection rates...
February 2017: Journal of Obstetrics and Gynaecology of India
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