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Endometrial receptivity

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https://www.readbyqxmd.com/read/28807395/clinical-validation-of-pinopode-as-a-marker-of-endometrial-receptivity-a-randomized-controlled-trial
#1
Zhang Qiong, Hao Jie, Wang Yonggang, Xu Bin, Zhao Jing, Li Yanping
OBJECTIVE: To determine the clinical value of pinopodes in the human. DESIGN: Randomized controlled trial. SETTING: Academic fertility center. PATIENT(S): From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited. INTERVENTION(S): In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28796907/likelihood-of-pregnancy-after-embryo-transfer-is-reduced-in-recipient-mares-with-a-short-preceding-oestrus
#2
J Cuervo-Arango, A N Claes, M Ruijter-Villani, T A Stout
BACKGROUND: Previous surveys reported a positive association between the length of the follicular phase and subsequent fertility in embryo transfer donor and Thoroughbred mares. However, it is unclear whether a longer oestrus positively influences fertilisation and oviductal development (oocyte quality, oviductal environment), or uterine receptivity and survival of the embryo in the uterus. OBJECTIVES: To determine the effect of length of oestrus (characterised by duration of endometrial oedema) on likelihood of pregnancy and early embryo loss (EEL) in recipient mares after embryo transfer (ET)...
August 10, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28791050/effect-of-increased-endometrial-thickness-and-implantation-rate-by-granulocyte-colony-stimulating-factor-on-unresponsive-thin-endometrium-in-fresh-in-vitro-fertilization-cycles-a-randomized-clinical-trial
#3
Fatemeh Sarvi, Marjan Arabahmadi, Ashraf Alleyassin, Marzieh Aghahosseini, Marzieh Ghasemi
BACKGROUND: The correlation between endometrial thickness and receptivity has been mentioned in various studies. This study investigated the effect of granulocyte colony-stimulating factor in treating thin endometrium of infertile women who were chosen for in vitro fertilization in our infertility clinic in 2014 and 2015. METHODS: In this randomized clinical trial, 28 women who were chosen for in vitro fertilization and had endometrial thickness of less than 6 mm on the day of human chorionic gonadotropin (hCG) injection were included in the study...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28771871/predicting-nk-cell-subsets-using-gene-expression-levels-in-peripheral-blood-and-endometrial-biopsy-specimens
#4
Michael L Davies, Svetlana V Dambaeva, Dimantha Katukurundage, Miroslava Repak, Alice Gilman-Sachs, Joanne Kwak-Kim, Kenneth D Beaman
PROBLEM: In molecular analysis of tissue biopsy specimens, one crucial aspect is characterization of immune cell populations. This is especially important for evaluation of uterine receptivity by assessing levels of lymphocyte populations including CD56(bright) CD16- uterine NK cells and CD56(dim) CD16+ conventional NK cells. Our objective was to investigate whether measuring total RNA transcripts from a tissue specimen would accurately reflect immune cell levels and be a new technique to assess immune cell subsets...
August 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28758253/mir-182-selectively-targets-hoxa10-in-goat-endometrial-epithelium-cells-in-vitro
#5
L Zhang, X-R Liu, J-Z Liu, Y-X Song, Z-Q Zhou, B-Y Cao
Proper HOXA10 expression was essential for endometrial receptivity what was crucial for successful embryo implantation in mammalian. This study confirmed that miR-182 regulated the expression levels of HOXA10 by binding to its 3' UTR, selectively downregulated HOXA10 in goat endometrial epithelium cells (gEECs) but not stromal cell (gESCs) in vitro. However, HOXA10 and miR-182 both up-expressed in the goat endometrium at gestational day 15 (D15) compared with gestational day 5 (D5), suggesting that there were some other factors regulated the expression of HOXA10 during the development of goat endometrium in vivo...
July 30, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28752711/-establishment-of-mouse-endometrial-injury-model-by-curettage-or-coagulation
#6
Wang Yanpeng, Huang Qiongxiao, X U Sheng, Shu Jing
Objective: To establish mouse endometrial injury model by curettage or coagulation. Methods: Female ICR mice were randomly allocated into 2 groups: in curettage group, a blunt 20G needle was inserted in one uterine horn with 0.05 megapascals negative pressure; in coagulation group, one uterine horn was coagulated using a monopolar electric needle with 0.5 watts power. In both groups the contra-lateral uterine horn was used as control. The morphological changes and thickness of endometrium were evaluated 1 week after operation...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28729745/insufficient-angiogenesis-cause-of-abnormally-thin-endometrium-in-subfertile-patients
#7
Joachim Alfer, Lars Happel, Ralf Dittrich, Matthias W Beckmann, Arndt Hartmann, Andreas Gaumann, Volker U Buck, Irmgard Classen-Linke
INTRODUCTION: This study investigated subfertile patients with abnormally thin endometrium after infertility treatment. As they had adequate serum concentrations of hormones, an endometrial factor for subfertility was suspected. METHODS: To elucidate the cause of subfertility, endometrial biopsies were taken in each patient in the late proliferative and mid-secretory phases of one menstrual cycle. Endometrial biopsies from women with normal menstrual cycles and confirmed fertility who were undergoing hysterectomy for benign uterine disease were used as positive controls...
July 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28723687/small-intestine-submucosa-is-a-potential-material-for-intrauterine-adhesions-treatment-in-a-rat-model
#8
Desheng Kong, Lin Zhang, Xin Xu, Jingkun Zhang, Yanan Li, Xianghua Huang
OBJECTIVE: To study whether small intestine submucosa (SIS) could be a treatment option for preventing the formation of intrauterine adhesions (IUAs). METHODS: The IUAs model was established by mechanical curettage and infectious injury in a rat model. One uterine horn of the rat model was treated with the transplantation of SIS (SIS group) and the other one was left without any treatment (control group). The endometrium was evaluated with endometrial thickness, number of glands and fibrosis area...
July 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28706275/novel-function-of-pregnancy-associated-plasma-protein-a-promotes-endometrium-receptivity-by-up-regulating-n-fucosylation
#9
Ming Yu, Jiao Wang, Shuai Liu, Xiaoqi Wang, Qiu Yan
Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to promote trophoblast cell proliferation and adhesion. However, the relationship between PAPPA and endometrium receptivity, as well as the regulation of N-fucosylation remains unclear. We found that rhPAPPA and PAPPA in the serum samples from pregnant women or conditioned medium of trophoblast cells promoted endometrium receptivity in vitro...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702979/use-of-platelet-rich-plasma-in-human-infertility
#10
G V L Colombo, V Fanton, D Sosa, E Criado Scholz, J Lotti, S E Aragona, T Lotti
Successful embryo implantation requires good quality embryo but also needs a receptive endometrium site. In our clinical practice, we daily verify that an adequate endometrial growth is reached for successful implantation. To understand whether platelet rich plasma (PRP) can improve endometrium thickness and performance, PRP treatment was carried out after at least three of the classic medical protocols currently in use had been unsuccessfully adopted. Eight patients with more than 3 cryo-transfers cancelled because of failure of endometrial growth, defined as endometrium less than 6 mm, with negative hysteroscopic screening for endometrial pathology, and with negative bacteriologic screening, before present and all previous treatment, were selected to undergo PRP treatment...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28683601/dysregulation-of-gda-expression-in-endometrium-of-women-with-endometriosis-implication-for-endometrial-receptivity
#11
Riccardo Focarelli, Alice Luddi, Vincenzo De Leo, Angela Capaldo, Anita Stendardi, Valentina Pavone, Linda Benincasa, Giuseppe Belmonte, Felice Petraglia, Paola Piomboni
Glycodelin-A (GdA) has been proposed to represent a potential biomarker of endometrial function, but little is known about its expression during the different phases of the menstrual cycle and under pathological conditions. In the light of its potential importance also in embryo implantation, we aimed to evaluate the expression profile of GdA as well as the presence of different glycosylated glycoforms and the immunolocalization in endometrial tissue from women with endometriosis and in women with proven fertility, at different times during the menstrual cycle...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28678802/mir-182-aids-in-receptive-endometrium-development-in-dairy-goats-by-down-regulating-ptn-expression
#12
Lei Zhang, Xiaorui Liu, Junze Liu, Zhanqin Zhou, Yuxuan Song, Binyun Cao, Xiaopeng An
Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle in humans and many other animals. Our previous data indicated that miR-182 levels increase 15.55-fold and pleiotrophin (PTN) levels decrease 20.97-fold in the receptive endometrium (RE, D15) compared with the pre-receptive endometrium (PE, D5) in dairy goats. The present study shows that miR-182 is widely expressed in different tissues of dairy goats and that its expression levels are regulated by E2 and P4 in endometrial epithelium cells (EECs)...
2017: PloS One
https://www.readbyqxmd.com/read/28676452/water-extracted-tubers-of-cyperus-rotundus-l-enhance-endometrial-receptivity-through-leukemia-inhibitory-factor-mediated-expression-of-integrin-%C3%AE-v%C3%AE-3-and-%C3%AE-v%C3%AE-5
#13
Hee-Jung Choi, Tae-Wook Chung, Mi-Ju Park, Yeon-Seop Jung, Syng-Ook Lee, Keuk-Jun Kim, Ki-Tae Ha
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus rotundus L. (CR) has been traditionally used as an herbal medicine in Asian countries to treat diverse gynecological disorders. However, the potential therapeutic effect of CR on endometrial receptivity for successful embryo implantation to treat female infertility has not been fully studied. AIM OF STUDY: The aim of this study was to evaluate the effect of water-extracted CR on endometrial receptivity by investigating the expression of leukemia inhibitory factor (LIF) and integrins, cell adhesion, and embryo implantation using mifepristone (RU486; RU)-induced implantation failure model...
July 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28668152/endometrial-receptivity-in-eutopic-endometrium-in-patients-with-endometriosis-it-is-not-affected-and%C3%A2-let-me-show-you-why
#14
REVIEW
Jose Miravet-Valenciano, María Ruiz-Alonso, Eva Gómez, Juan A Garcia-Velasco
Many women with endometriosis experience compromised fertility. This disease clearly exerts quantitative damage on the ovaries, and perhaps, also qualitative damage. However, it remains controversial whether endometrial receptivity is compromised. Here we review the evidence from basic transcriptomic signature data to clinical data from an oocyte donation model and find support for the concept that endometrial receptivity is not impaired in women with endometriosis when healthy embryos reach the endometrial cavity...
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28668151/implantation-failure-of-endometrial-origin-it-is-not-pathology-but-our-failure-to-synchronize-the-developing-embryo-with-a-receptive-endometrium
#15
REVIEW
Cecilia T Valdes, Amy Schutt, Carlos Simon
Repeated implantation failure (RIF) is an intriguing, massive failure of reproductive treatment in otherwise healthy women leading to the introduction of empirical adjuvant interventions that are costly, inefficient, and frustrating for our patients. In this article, we will try to convince the readers that RIF is neither a stigma nor a mysterious pathology but rather our failure to diagnose and properly synchronize the euploid blastocyst with the patient's personalized window of implantation.
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28634372/dna-methylation-changes-in-endometrium-and-correlation-with-gene-expression-during-the-transition-from-pre-receptive-to-receptive-phase
#16
Viktorija Kukushkina, Vijayachitra Modhukur, Marina Suhorutšenko, Maire Peters, Reedik Mägi, Nilufer Rahmioglu, Agne Velthut-Meikas, Signe Altmäe, Francisco J Esteban, Jaak Vilo, Krina Zondervan, Andres Salumets, Triin Laisk-Podar
The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial methylome changes throughout the menstrual cycle. The impact of methylome changes on gene expression and thereby on the function of the tissue, including establishing receptivity to implanting embryo, is also unclear. Therefore, this study used genome-wide technologies to characterize the methylome and the correlation between DNA methylation and gene expression in endometrial biopsies collected from 17 healthy fertile-aged women from pre-receptive and receptive phase within one menstrual cycle...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631552/effect-of-2-3-4-4-5-pentachlorobiphenyl-exposure-on-endometrial-receptivity-and-the-methylation-of-hoxa10
#17
Xin-Lan Qu, Ming-Zhang, Yuan-Fang, Hui Wang, Yuan-Zhen Zhang
Polychlorinated biphenyls (PCBs) are one of the most common endocrine-disrupting chemicals and have obvious toxicity on human reproductive development. The aim of our study was to investigate the toxicity of chronic 2,3',4,4',5-pentachlorobiphenyl (PCB 118) exposure on embryo implantation and endometrial receptivity, with the possible mechanism of DNA methylation involved. Virgin CD-1 female mice (3 weeks old) were housed and orally treated with PCB 118 (0, 1, 10, 100 μg/kg) for a month. After mating with fertile males, the pregnant mice were killed on gestation day 4...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28630707/evidence-of-endometrial-amino-acid-metabolism-and-transport-modulation-by-peri-ovulatory-endocrine-profiles-driving-uterine-receptivity
#18
Moana Rodrigues França, Maressa Izabel Santos da Silva, Guilherme Pugliesi, Veerle Van Hoeck, Mario Binelli
BACKGROUND: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle (POF) and the resulting elevated concentrations of progesterone (P4) during diestrus positively affect pregnancy rates. Amino acids (AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28629172/the-role-of-hcg-in-implantation-a-mini-review-of-molecular-and-clinical-evidence
#19
REVIEW
Antonis Makrigiannakis, Thomas Vrekoussis, Emmanouel Zoumakis, Sophia N Kalantaridou, Udo Jeschke
Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28628266/embryo-maternal-dialogue-during-pregnancy-establishment-and-implantation-in-the-pig
#20
REVIEW
Agnieszka Waclawik, Monika M Kaczmarek, Agnieszka Blitek, Piotr Kaczynski, Adam J Ziecik
Porcine conceptuses secrete pregnancy-recognition signals (estrogens, including estradiol-17β) that inhibit luteolysis, thereby prolonging progesterone production by corpora lutea. The supportive mechanism by which the conceptus also inhibits luteolysis is by shifting endometrial prostaglandin (PG) synthesis to luteoprotective PGE2. Progesterone stimulates endometrial production of factors that are essential for conceptus development. Priming the uterus by progesterone and loss of progesterone receptors from the uterine epithelium by D1ay 10-12 after estrus are key for achieving endometrial receptivity for implantation...
June 19, 2017: Molecular Reproduction and Development
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