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Xiaodong Sun, Zhongqi Fan, Wei Qiu, Yuguo Chen, Chao Jiang, Guoyue Lv
RATIONALE: Median arcuate ligament (MAL) may compress the coeliac trunk inducing median arcuate ligament syndrome (MALS). MALS is a risk factor for hepatic artery thrombosis (HAT) in liver transplant recipients. PATIENT CONCERNS: A thin female complained about upper abdominal pain for two months. DIAGNOSES: The patient was diagnosed as primary biliary cirrhosis. INTERVENTIONS: The patient received two liver transplantations...
June 2018: Medicine (Baltimore)
Julia Greiser, Christian Kühnel, Helmar Görls, Wolfgang Weigand, Martin Freesmeyer
We report the isolation of a new type of 1,4-diazepan-6-amine (DAZA)-based ligand. Condensation of aldehydes with DAZA gives a novel class of 1,5-diazabicyclo[3.2.1]octanes in nearly quantitative yields. Subsequent reductive cleavage of these bicyclic aminal species with sodium borohydride selectively leads to N,1,4-tri(4-alkoxy-2-hydroxybenzyl)-1,4-diazepan-6-amines (alkoxy = Me: TMeOHB-DAZA; alkoxy = Et: TEtOHB-DAZA) via a unique reductive alkylation reaction in which a substituent is added to the DAZA moiety without the presence of an alkylating agent...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
A Tornambè, P S L Aiello, G Tornambè
Gallbladder cancer is the most frequent neoplasm originating from the extrahepatic biliary tract, with characteristics of late presentation and rapid progression. We report the case of a 58 years old female patient with concomitant small cell carcinoma and adenocarcinoma of the gallbladder, incidentally reported after a cholecystectomy performed for cholelithiasis. According to the stage of the disease, we performed a second surgical procedure with laparotomy, resection of the liver parenchyma IVb and V and regional lymphadenectomy...
May 2018: Il Giornale di Chirurgia
González-Urquijo Mauricio, Hinojosa-Gonzalez David Eugenio, Quevedo-Fernandez Enrique
Introduction: A cholecystocolonic fistula (CCF) is a late complication following repeated episodes of chronic inflammation of the gallbladder in contact with the hepatic flexure, and it might cause a biliary ileus in the colon, causing an intestinal obstruction, and if left untreated, a life threatening disease. Presentation of case: a 49-year-old female patient presented with abdominal pain and bowel obstruction due to a gallstone impaction on the sigmoid colon as consequence of a cholecystocolonic fistula...
July 2018: Annals of Medicine and Surgery
Yaron Ilan, Kunwar Shailubhai, Arun Sanyal
BACKGROUND: The immune system plays a role in the pathogenesis of NASH underlying hepatocyte injury and fibrosis progression at all disease stages. Oral administration of anti-CD3 monoclonal antibody (mAb) has been shown in pre-clinical studies to be an effective method for systemic immune modulation and alleviates immune-mediated disorders without T-cell depletion. AIM: In the present review, we summarize the concept of the oral administration of humanized anti-CD3 mAb in patients with NASH and discuss the potential of this treatment to address the current requirements of treatments for NASH...
June 19, 2018: Clinical and Experimental Immunology
Andrew J Kruger, Somashekar G Krishna
No abstract text is available yet for this article.
June 19, 2018: Endoscopy
Ahmad Hashim, Corey Miller, Ali Bessissow, David Valenti, Alan Barkun, Jeffrey Barkun, Yen-I Chen
No abstract text is available yet for this article.
June 19, 2018: Endoscopy
Hiren Vallabh, Sardar Shah-Khan, John Nasr
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Ihab I El Hajj, Glen A Lehman, Evan L Fogel, Jeffrey J Easler, James L Watkins, Stuart Sherman
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Jong Jin Hyun, Richard A Kozarek
PURPOSE OF REVIEW: To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS: The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture...
June 16, 2018: Current Opinion in Gastroenterology
Yukitoshi Matsunami, Takao Itoi, Takayoshi Tsuchiya, Ryosuke Tonozuka, Shuntaro Mukai
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Sundeep Lakhtakia, Radhika Chavan, Mohan Ramchandani, Zaheer Nabi, D Nageshwar Reddy
No abstract text is available yet for this article.
April 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Jean-Baptiste Cazauran, Lucas Pâris, Pascal Rousset, Frédéric Mercier, Vahan Kepenekian, Anthony Viste, Guillaume Passot
BACKGROUND: Surgery remains the gold standard both for delimited hepatocellular carcinoma by selective anatomic liver segentectomy and for colorectal liver metastases by parenchymal sparing liver resection. Right anterior sector (RAS) (segments V-VIII; Couinaud) is the largest and most difficult sector to operate on. A better knowledge of its segmentation could prevent postoperative remnant liver ischemia and its impacts on patient's survival. METHODS: A literature search was conducted in PubMed for papers on anatomy and surgery of the right anterior sector...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Alejandro V Garcia, Mitchell R Ladd, Todd Crawford, Katherine Culbreath, Oswald Tetteh, Samuel M Alaish, Emily F Boss, Daniel S Rhee
OBJECTIVE: To evaluate the perioperative risk factors for 30-day complications of the Kasai procedure in a large, cross-institutional, modern dataset. STUDY DESIGN: The 2012-2015 National Surgical Quality Improvement Program Pediatric database was used to identify patients undergoing the Kasai procedure. Patients' characteristics were compared by perioperative blood transfusions and 30-day outcomes, including complications, reoperations, and readmissions. Multivariable logistic regression was used to identify risk factors predictive of outcomes...
June 18, 2018: Pediatric Surgery International
Manoj Kumar, Gilad Shapira, Alex Wiles, Caitline Marshall, Divya Nadella, Meir Mizrahi
Endoscopic ultrasound (EUS)-guided transluminal drainage of obstructed bile duct with conventional metal and plastic stents has been in practice for several years, but this modality carries its own potential complications and obstacles. Nevertheless, the novel Hot AXIOS stent (Boston Scientific Corp., Marlborough, MA) has been shown to overcome some of those factors, which justifies its application in a variety of clinical indications, such as EUS-guided choledochoduodenostomy (EUS-CDS) for biliary drainage after failed endoscopic retrograde cholangiopancreatography...
2018: ACG Case Reports Journal
Muhammad Bader Hammami, Elizabeth M Noonan, Anuj Chhaparia, Feras Al Khatib, Juri Bassuner, Christine Hachem
Pyogenic liver abscesses (PLA) develop from the spread of infection through the portal circulation, biliary infections or arterial hematogenous seeding in the setting of systemic infections. PLA are often poly-microbial and are uncommonly reported to be due to anaerobic species. We report the case of a previously healthy, immunocompetent 63-year-old man with hepatic abscesses as a result of Fusobacterium nucleatum periodontal disease. In addition, a systemic review of the literature is performed. Fusobacterium is a very rare cause of PLA in immunocompetent hosts with only a handful of cases reported in the literature...
June 2018: Gastroenterology Research
Syed Hasan, Zubair Khan, Mohammad Saud Khan, Umar Darr, Toseef Javaid, Raheel Ahmed, Ali Nawras
We present a case of a 60-year-old female patient who has significant medical history of renal cell carcinoma diagnosed 2 years back and had undergone right nephrectomy and chemotherapy. She presented to the hospital with complaints of abdominal pain and jaundice of 2 weeks duration and was found to have periampullary mass lesion causing compression of distal common bile duct on imaging with computed tomography of abdomen. Endoscopic retrograde cholangiography and endoscopic ultrasound showed ampullary mass lesion causing biliary obstruction along with abdominal lymphadenopathy...
June 2018: Gastroenterology Research
Anthony S Casabianca, Mihir M Shah, Darren Carpizo
An 84-year-old man presented with pancreatic adenocarcinoma. Following neoadjuvant chemoradiation, the patient underwent a pancreaticoduodenectomy, complicated by early bile leak. Re-exploration and intraoperative cholangiogram identified an accessory common bile duct draining segment 5 of the right hepatic lobe, which was then ligated. The patient underwent a complicated postoperative course eventually developing sepsis secondary to biliary stasis. He elected for comfort measures and passed away secondary to complications of sepsis...
June 17, 2018: BMJ Case Reports
Pimradasiri Srijiwangsa, Saranyoo Ponnikorn, Kesara Na-Bangchang
BACKGROUND: Cholangiocarcinoma (CCA), an epithelial malignancy of the biliary tree, is one of the aggressive cancers with poor prognosis and unsatisfactory response to chemotherapy with acquired resistance. NAD(P)H-quinone oxidoreductase 1 (NQO1), an antioxidant/detoxifying enzyme, plays important roles in chemo-resistance and proliferation in several cancer cells. The study aimed to investigate the inhibitory effect of β-eudesmol on NQO1 enhanced chemotherapeutic effects of 5-fluorouracil (5-FU) and doxorubicin (DOX) in the high NQO1-expressing human CCA cell line, NQO1-KKU-100...
June 19, 2018: BMC Pharmacology & Toxicology
Louai R Zaidan, Elhaitham K Ahmed, Bachar Halimeh, Yasser Radwan, Khalil Terro
BACKGROUND: Chylous ascites is considered to be an intra-abdominal collection of creamy colored fluid with triglyceride content of > 110 mg/dL. Chylous ascites is an uncommon but serious complication of numerous surgical interventions. However, it is a rare complication of LRYGB. An internal hernia limb defect is thought to be the underlying etiology, where the hernia will cause lymphatic vessel engorgement and lymphatic extravasation. CASE PRESENTATION: We report a case of a 29 years old male with a 9 year history of laparoscopic Roux en y gastric bypass (LRGYB), presenting with recurrent abdominal pain for 2 months radiating to the right shoulder...
June 19, 2018: BMC Surgery
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