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Urinary Bladder Matrix

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https://www.readbyqxmd.com/read/29133168/autologous-granulation-tissue-tubes-for-replacement-of-urethral-defects-an-experimental-study-in-male-rabbits
#1
Shi-Wei Jiang, Zhong-Hua Xu, Yuan-Yuan Zhao, Lei Yan, Zun-Lin Zhou, Gang-Li Gu
INTRODUCTION: Tubularized urethroplasty is commonly performed in clinical practice using genital skin flaps, bladder mucosa, and buccal mucosa. However, the long-term effects are not satisfying, and donor site morbidities remain a problem. Besides, those grafts are unavailable with malignant conditions of the urinary tract, a history of lichen sclerosis, or oral disease. OBJECTIVE: An autologous granulation tissue tube of any required length and diameter can be produced by implanting foreign objects subcutaneously (Summary Fig...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29109844/porcine-urinary-bladder-extracellular-matrix-for-the-salvage-of-fibula-free-flap-skin-paddle-technical-note-and-description-of-a-case
#2
REVIEW
Rabie M Shanti, Ryan J Smart, Andrew Meram, David Kim
This report establishes a novel application of a commercially available porcine urinary bladder extracellular matrix, MatriStem (ACell, Inc., Columbia, MD), in the salvage of partial loss of the skin paddle of a fibula osteoseptocutaneous free flap that was utilized for mandibular reconstruction.
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29046294/local-ca-2-coupling-between-mitochondria-and-sarcoplasmic-reticulum-following-depolarization-in-guinea-pig-urinary-bladder-smooth-muscle-cells
#3
Hisao Yamamura, Keisuke Kawasaki, Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi
Spatiotemporal changes in cytosolic Ca(2+) concentration ([Ca(2+)]c) trigger a number of physiological functions in smooth muscle cells (SMCs). We previously imaged Ca(2+)-induced Ca(2+) release following membrane depolarization as local Ca(2+) transients, Ca(2+) hotspots, in subplasmalemmal regions. In this study, the physiological significance of mitochondria on local Ca(2+) signaling was examined. Cytosolic and mitochondrial Ca(2+) images following depolarization or action potentials were recorded in single SMCs from the guinea pig urinary bladder using a fast-scanning confocal fluorescent microscope...
October 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29040321/co-delivery-of-micronized-urinary-bladder-matrix-damps-regenerative-capacity-of-minced-muscle-grafts-in-the-treatment-of-volumetric-muscle-loss-injuries
#4
Stephen M Goldman, Benjamin T Corona
Minced muscle grafts (MG) promote de novo muscle fiber regeneration and neuromuscular strength recovery in small and large animal models of volumetric muscle loss. The most noteworthy limitation of this approach is its reliance on a finite supply of donor tissue. To address this shortcoming, this study sought to evaluate micronized acellular urinary bladder matrix (UBM) as a scaffolding to promote in vivo expansion of this MG therapy in a rat model. Rats received volumetric muscle loss injuries to the tibialis anterior muscle of their left hind limb which were either left untreated or repaired with minced muscle graft at dosages of 50% and 100% of the defect mass, urinary bladder matrix in isolation, or a with an expansion product consisting of a combination of the two putative therapies in which the minced graft is delivered at a dosage of 50% of the defect mass...
2017: PloS One
https://www.readbyqxmd.com/read/29031295/competitive-amperometric-immunosensor-for-determination-of-p53-protein-in-urine-with-carbon-nanotubes-gold-nanoparticles-screen-printed-electrodes-a-potential-rapid-and-noninvasive-screening-tool-for-early-diagnosis-of-urinary-tract-carcinoma
#5
Marco Giannetto, Maria Vittoria Bianchi, Monica Mattarozzi, Maria Careri
Since p53 protein has become recognized biomarker for both diagnostic and therapeutic purposes in oncological diseases with particular relevance for bladder cancer, it is highly desirable to search for a novel sensing tool for detecting the patient's p53 level at the early stage. Here we report the first study on the development and validation of a novel disposable competitive amperometric immunosensor for determination of p53 protein at subnanomolar levels, based on p53 immobilization on gold nanoparticles/carbon nanotubes modified screen-printed carbon electrodes...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28988966/murine-social-stress-results-in-long-lasting-voiding-dysfunction
#6
Stephan Butler, Sandra Luz, Kile McFadden, Joanna Fesi, Christopher Long, Lynn Spruce, Steven Seeholzer, Douglas Canning, Rita Valentino, Stephen Zderic
Repeated exposure to social stress shifts the voiding phenotype in male mice leading to bladder wall remodeling and is associated with increased expression of the stress neuropeptide, corticotropin-releasing factor (CRF) in Barrington's nucleus neurons. In these studies, we set out to determine if the voiding phenotype could recover upon removal from the stressor. Male mice were exposed for 1h daily to an aggressor and the voiding phenotype was assessed at one month followed by randomization to three groups...
January 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/28974397/comprehensive-genomic-sequencing-of-urothelial-tumors-identifies-rare-smarcb1-ini-1-deficient-carcinomas-of-the-urinary%C3%A2-system
#7
Sumati Gupta, Daniel Albertson, David Gaston, Marta E Heilbrun, Neeraj Agarwal, Ken Boucher, Timothy J Parnell, Ting Liu, Alicia Morgans, Russell Madison, Kyle Gowen, Vincent A Miller, Jeffrey S Ross, Siraj M Ali, Sherri Z Millis
PURPOSE: Tumor genomic profiling helps direct therapy for advanced urothelial carcinoma (UC). In the course of clinical care, we encountered a patient with a complete loss of SMARCB1 (switch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), which encodes INI-1 (integrase interactor 1), as the sole detected driver of their urinary tract tumor. Our objective was the identification and genomic characterization of urinary tract neoplasia with complete SMARCB1 loss...
September 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28943942/honokiol-inhibits-bladder-cancer-cell-invasion-through-repressing-src-3-expression-and-epithelial-mesenchymal-transition
#8
Lan Shen, Fang Zhang, Ruimin Huang, Jun Yan, Bing Shen
Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition by induction of E-cadherin and repression of N-cadherin...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28929035/porcine-urinary-bladder-matrix-for-management-of-infected-radiation-mastectomy-wound
#9
Yana Puckett, Theophilus Pham, Shirley McReynolds, Catherine A Ronaghan
We present a case report on the successful healing of a Pseudomonas infection wound in a 52-year-old female with morbid obesity, noninsulin dependent diabetes mellitus and a history of tobacco use, who presented with Stage IIIA (T3, N2, Mo) infiltrating ductal carcinoma. The patient received neoadjuvant chemotherapy prior to her bilateral skin-sparing total mastectomies with right axillary sentinel lymphadenectomy. She also had staged reconstruction with temporary breast implants and plans for deep inferior epigastric perforator flaps...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28827106/evaluation-of-biofilm-induced-urinary-infection-stone-formation-in-a-novel-laboratory-model-system
#10
Trace Hobbs, Logan N Schultz, Ellen G Lauchnor, Robin Gerlach, Dirk Lange
PURPOSE: Infection stones, which comprise approximately 15% of all urinary tract stones, are induced by infection with urease-positive pathogens. The bacteria in the stone matrix present significant treatment impediments compared to metabolic kidney stones. While much is known about how urinary composition regulates metabolic stone formation, there is a general lack of knowledge of which urinary factors regulate the rate of infection stone formation. Unfortunately more in-depth research into infection stones is limited by the lack of suitable models for real-time study of bacterial biofilm formation and stone formation under varying conditions...
August 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28811169/tissue-engineered-extracellular-matrices-ecms-in-urology-evolution-and-future-directions
#11
REVIEW
N F Davis, E M Cunnane, F J O'Brien, J J Mulvihill, M T Walsh
Autologous gastrointestinal tissue has remained the gold-standard reconstructive biomaterial in urology for >100 years. Mucus-secreting epithelium is associated with lifelong metabolic and neuromechanical complications when implanted into the urinary tract. Therefore, the availability of biocompatible tissue-engineered biomaterials such as extracellular matrix (ECM) scaffolds may provide an attractive alternative for urologists. ECMs are decellularised, biodegradable membranes that have shown promise for repairing defective urinary tract segments in vitro and in vivo by inducing a host-derived tissue remodelling response after implantation...
August 12, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28736160/macrophage-phenotype-in-response-to-ecm-bioscaffolds
#12
REVIEW
Luai Huleihel, Jenna L Dziki, Joseph G Bartolacci, Theresa Rausch, Michelle E Scarritt, Madeline C Cramer, Tatiana Vorobyov, Samuel T LoPresti, Ilea T Swineheart, Lisa J White, Bryan N Brown, Stephen F Badylak
Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular matrix (ECM), but phenotypic characterization of macrophages has typically been limited to small number of non-specific cell surface markers or expressed proteins. The present study determined the response of both primary murine bone marrow derived macrophages (BMDM) and a transformed human mononuclear cell line (THP-1 cells) to degradation products of two different, commonly used ECM bioscaffolds; urinary bladder matrix (UBM-ECM) and small intestinal submucosa (SIS-ECM)...
February 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28711025/three-dimensional-mechano-electrochemical-model-for-smooth-muscle-contraction-of-the-urinary-bladder
#13
Robert Seydewitz, Robin Menzel, Tobias Siebert, Markus Böl
The urinary bladder is a central organ of vertebrates and imposes, based on its extreme deformation (volume changes up to several 100%), special requirements on the overall bladder tissue. However, studies focusing on three-dimensional modelling of bladder deformation and bladder function during micturition are rare. Based on three fields, namely, the membrane potential, calcium concentration, and placement, a mechano-electrochemical-coupled, three-dimensional model describing the contractile behaviour of urinary bladder smooth muscle is presented using a strain energy function...
April 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28694741/role-of-matrix-metalloproteinase-13-gene-expression-in-the-evaluation-of-radiation-response-in-oral-squamous-cell-carcinoma
#14
Shankar Sharan Singh, Madan Lal Brahma Bhatt, Vandana Singh Kushwaha, Anshuman Singh, Rajendra Kumar, Rajeev Gupta, Devendra Parmar
BACKGROUND: Matrix Metalloproteinase 13 (MMP13) is a member of collagenase family and it is involved in the degradation of extracellular matrix and basement membrane protein. It is thought to be associated with tumor invasion and metastasis. Elevated MMP13 expression has been found in carcinoma of the breast, urinary bladder, head and neck and others. It is observed that MMP13 gene is also correlated with radiation response in OSCC (Oral squamous cell carcinoma) cell line based study...
2017: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/28660185/dedifferentiated-chondrocytes-in-composite-microfibers-as-tool-for-cartilage-repair
#15
Marco Angelozzi, Letizia Penolazzi, Stefania Mazzitelli, Elisabetta Lambertini, Andrea Lolli, Roberta Piva, Claudio Nastruzzi
Tissue engineering (TE) approaches using biomaterials have gain important roles in the regeneration of cartilage. This paper describes the production by microfluidics of alginate-based microfibers containing both extracellular matrix (ECM)-derived biomaterials and chondrocytes. As ECM components gelatin or decellularized urinary bladder matrix (UBM) were investigated. The effectiveness of the composite microfibers has been tested to modulate the behavior and redifferentiation of dedifferentiated chondrocytes...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28646909/the-morphological-regeneration-and-functional-restoration-of-bladder-defects-by-a-novel-scaffold-and-adipose-derived-stem-cells-in-a-rat-augmentation-model
#16
Qiong Wang, Dong-Dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang, Mu-Jun Lu
BACKGROUND: Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladder regeneration and restore bladder function. However, the low survival rate of ASCs and the difficulty of promoting bladder functional recovery are still unsolved. To explore these problems, we investigated the feasibility of a novel scaffold seeded with ASCs in a rat model of bladder augmentation...
June 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28634932/preparation-of-decellularized-biological-scaffolds-for-3d-cell-culture
#17
Bryan N Brown, Michael J Buckenmeyer, Travis A Prest
The biggest challenge of designing and implementing an in vitro study is developing a microenvironment that most closely represents the interactions observed in vivo. Decellularization of tissues and organs has been shown to be an effective method for the removal of potentially immunogenic constituents while preserving essential growth factors and extracellular matrix (ECM ) proteins necessary for proper cell function. Enzymatic digestion of decellularized tissues allows these tissue-specific components to be reconstituted into bioactive hydrogels through a physical crosslinking of collagen...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28631918/-using-of-cell-biocomposite-material-in-tissue-engineering-of-the-urinary-bladder
#18
REVIEW
P V Glybochko, Yu V Olefir, Yu G Alyaev, D V Butnaru, E A Bezrukov, A A Chaplenko, T M Zharikova
In a systematic review, to present an overview of the current situation in the field of tissue engineering of urinary bladder related to the use of cell lines pre-cultured on matrices. The selection of eligible publications was conducted according to the method described in the article Glybochko P.V. et al. "Tissue engineering of urinary bladder using acellular matrix." At the final stage, studies investigating the application of matrices with human and animal cell lines were analyzed. Contemporary approaches to using cell-based tissue engineering of the bladder were analyzed, including the formation of 3D structures from several types of cells, cell layers and genetic modification of injected cells...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28605134/impact-of-direct-epispinal-stimulation-on-bladder-and-bowel-functions-in-pigs-a-feasibility-study
#19
Thomas Guiho, Claire Delleci, Christine Azevedo-Coste, Charles Fattal, David Guiraud, Jean-Rodolphe Vignes, Luc Bauchet
AIMS: This study assesses the potential of epispinal (subdural) stimulation application in the treatment of urinary and bowel neurological disorders. Acute experiments were performed on a large animal model - the domestic pig - to develop a new methodology facilitating future results and technology transfers to human. METHODS: After rectal and bladder catheterization, four Landrace pigs (45-50 kg) underwent spinal cord surgery - that is, lumbosacral incision, laminectomy [L4-S4], dural opening and microsurgical arachnoid dissection...
June 12, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28583764/proteomic-composition-and-immunomodulatory-properties-of-urinary-bladder-matrix-scaffolds-in-homeostasis-and-injury
#20
REVIEW
Kaitlyn Sadtler, Sven D Sommerfeld, Matthew T Wolf, Xiaokun Wang, Shoumyo Majumdar, Liam Chung, Dhanashree S Kelkar, Akhilesh Pandey, Jennifer H Elisseeff
Urinary bladder matrix (UBM) is used clinically for management of wounds and reinforcement of surgical soft tissue repair, among other applications. UBM consists of the lamina propria and basal lamina of the porcine urinary bladder, and is decellularized as part of the process to manufacture the medical device. UBM is composed mainly of Collagen I, but also contains a wide variety of fibrillar and basement membrane collagens, glycoproteins, proteoglycans and ECM-associated factors. Upon application of the biomaterial in a traumatic or non-traumatic setting in a mouse model, there is a cascade of immune cells that respond to the damaged tissue and biomaterial...
February 2017: Seminars in Immunology
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