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Urinary Bladder Matrix

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https://www.readbyqxmd.com/read/29772347/location-dependent-correlation-between-tissue-structure-and-the-mechanical-behaviour-of-the-urinary-bladder
#1
Enrique Morales-Orcajo, Tobias Siebert, Markus Böl
The mechanical properties of the urinary bladder wall are important to understand its filling-voiding cycle in health and disease. However, much remains unknown about its mechanical properties, especially regarding regional heterogeneities and wall microstructure. The present study aimed to assess the regional differences in the mechanical properties and microstructure of the urinary bladder wall. Ninety (n=90) samples of porcine urinary bladder wall (ten samples from nine different locations) were mechanically and histologically analysed...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29726304/retrorectus-repair-of-incisional-ventral-hernia-with-urinary-bladder-matrix-reinforcement-in-a-long-term-porcine-model
#2
D Adam Young, Nicolette Jackson, Catherine A Ronaghan, Collin Em Brathwaite, Thomas W Gilbert
AIM: Not all biologically derived materials elicit the same host response when used for reinforcement of ventral hernia repairs. This study aimed to evaluate the remodeling characteristics of the abdominal wall following reinforcement with urinary bladder matrix (UBM) in a large animal preclinical model of ventral hernia repair. MATERIALS & METHODS: Midline defects in 36 Yucatan minipigs were reinforced with UBM-derived surgical devices using a classic Rives-Stoppa-Wantz approach, and compared with primary repair controls...
May 4, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29675793/no-influence-of-smoking-status-on-the-performance-of-urine-markers-for-the-detection-of-bladder-cancer
#3
Susanne Deininger, J Hennenlotter, S Rausch, K Docktor, E Neumann, I A da Costa, J Bedke, A Stenzl, T Todenhöfer
PURPOSE: The performance of urinary markers for detecting bladder cancer (BC) is influenced by various factors. The aim of the present study was to evaluate the influence of smoking habits on the performance of four commonly used urine markers. METHODS: Urine samples of 723 patients with suspected BC were analysed using urine cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+ test), and quantitative nuclear matrix protein 22 (NMP22) immunoassay...
April 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29665503/zebrafish-extracellular-matrix-improves-neuronal-viability-and-network-formation-in-a-3-dimensional-culture
#4
Sung-Min Kim, Daniel Ward Long, Michael Wai Kok Tsang, Yadong Wang
Mammalian central nervous system (CNS) has limited capacity for regeneration. CNS injuries cause life-long debilitation and lead to $50 billion in healthcare costs in U.S. alone each year. Despite numerous efforts in the last few decades, CNS-related injuries remain as detrimental as they were 50 years ago. Some functional recovery can occur, but most regeneration are limited by an extracellular matrix (ECM) that actively inhibits axonal repair and promotes glial scarring. In most tissues, the ECM is an architectural foundation that plays an active role in supporting cellular development and regenerative response after injury...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29651327/performance-of-urinary-markers-for-detection-of-upper-tract-urothelial-carcinoma-is-upper-tract-urine-more-accurate-than-urine-from-the-bladder
#5
Simone Bier, Jörg Hennenlotter, Michael Esser, Sarah Mohrhardt, Steffen Rausch, Christian Schwentner, Moritz Maas, Susanne Deininger, Simon Walz, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
Objectives: To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). Patients and Methods: The study comprised 758 urine samples either collected from the bladder ( n = 373) or UUT ( n = 385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed...
2018: Disease Markers
https://www.readbyqxmd.com/read/29649634/injectable-porous-biohybrid-hydrogels-incorporating-decellularized-tissue-components-for-soft-tissue-applications
#6
Yang Zhu, Sato Hideyoshi, Hongbin Jiang, Yasumoto Matsumura, Jenna L Dziki, Samuel T LoPresti, Luai Huleihel, Gabriela N F Faria, Leah C Fuhrman, Ricardo Lodono, Stephen F Badylak, William R Wagner
Biodegradable injectable hydrogels have been extensively studied and evaluated in various medical applications such as for bulking agents, drug delivery reservoirs, temporary barriers, adhesives, and cell delivery matrices. Where injectable hydrogels are intended to facilitate a healing response, it may be desirable to encourage rapid cellular infiltration into the hydrogel volume from the tissue surrounding the injection site. In this study, we developed a platform technique to rapidly form pores in a thermally responsive injectable hydrogel, poly(NIPAAm-co-VP-co-MAPLA) by using mannitol particles as porogens...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29588511/structure-and-distribution-of-an-unrecognized-interstitium-in-human-tissues
#7
Petros C Benias, Rebecca G Wells, Bridget Sackey-Aboagye, Heather Klavan, Jason Reidy, Darren Buonocore, Markus Miranda, Susan Kornacki, Michael Wayne, David L Carr-Locke, Neil D Theise
Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60-70 μm during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29588320/urinary-bladder-cancer-tregs-suppress-mmp2-and-potentially-regulate-invasiveness
#8
Malin E Winerdal, David Krantz, Ciputra A Hartana, Ali A Zirakzadeh, Ludvig Linton, Emma A Bergman, Robert Rosenblatt, Janos Vasko, Farhood Alamdari, Johan Hansson, Benny Holmström, Markus Johansson, Max Winerdal, Per Marits, Amir Sherif, Ola Winqvist
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of Tregs on certain malignancies, including urinary bladder cancer (UBC). This discrepancy has partly been attributed to the shear misidentification of Tregs, but also to the inflammatory profile of the tumor. Our aim was to determine whether tumor-infiltrating Forkhead box P3+ (FOXP3+ ) cells confer a stable Treg phenotype and to investigate putative beneficial Treg functions, focusing on tumor-promoting inflammatory pathways in UBC...
March 27, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29578150/elevated-expression-of-matrix-metalloproteinase-9-is-associated-with-bladder-cancer-pathogenesis
#9
Gong-Jin Wu, Jun-Sheng Bao, Zhong-Jin Yue, Fan-Chang Zeng, Song Cen, Zheng-Yan Tang, Xin-Li Kang
Objective: This study investigated the association between abnormal matrix metalloproteinase-9 (MMP-9) expression and bladder cancer (BC) development. Materials and Methods: In a retrospective analysis, this study used tissue samples derived from 92 patients pathologically diagnosed with BC (experimental group), who were hospitalized between September 2012 and June 2014 at the Urinary Surgery of Department of Urology, Lanzhou University Second Hospital. As controls (control group), 63 normal pericancerous bladder mucosal tissues (3 cm distant form edge of BC foci) with confirmed pathology were selected from the same time period...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29549123/wnt7a-activates-canonical-wnt-signaling-promotes-bladder-cancer-cell-invasion-and-is-suppressed-by-mir-370-3p
#10
Xiaojing Huang, Hongwen Zhu, Zemin Gao, Junzun Li, Junlong Zhuang, Yu Dong, Bing Shen, Meiqian Li, Hu Zhou, Hongqian Guo, Ruimin Huang, Jun Yan
Once urinary bladder cancer (UBC) develops into muscle-invasive bladder cancer, its mortality rate increases dramatically. However, the molecular mechanisms of UBC invasion and metastasis remain largely unknown. Herein, using 5637 UBC cells, we generated two sublines with low (5637 NMI) and high (5637 HMI) invasive capabilities. Mass spectrum analyses revealed that the Wnt family protein Wnt7a is more highly expressed in 5637 HMI cells than in 5637 NMI cells. We also found that increased Wnt7a expression is associated with UBC metastasis and predicted worse clinical outcome in UBC patients...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29540763/fetal-extracellular-matrix-nerve-wraps-locally-improve-peripheral-nerve-remodeling-after-complete-transection-and-direct-repair-in-rat
#11
Tanchen Ren, Anne Faust, Yolandi van der Merwe, Bo Xiao, Scott Johnson, Apoorva Kandakatla, Vijay S Gorantla, Stephen F Badylak, Kia M Washington, Michael B Steketee
In peripheral nerve (PN) injuries requiring surgical repair, as in PN transection, cellular and ECM remodeling at PN epineurial repair sites is hypothesized to reduce PN functional outcomes by slowing, misdirecting, or preventing axons from regrowing appropriately across the repair site. Herein this study reports on deriving and analyzing fetal porcine urinary bladder extracellular matrix (fUB-ECM) by vacuum assisted decellularization, fabricating fUBM-ECM nerve wraps, and testing fUB-ECM nerve wrap biocompatibility and bioactivity in a trigeminal, infraorbital nerve (ION) branch transection and direct end-to-end repair model in rat...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29486883/photodynamic-therapy-and-diagnosis-principles-and-comparative-aspects
#12
REVIEW
Jane Dobson, Genilson Fernandes de Queiroz, Jon P Golding
Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective photosensitiser dyes, tissue oxygen and targeted illumination to generate cytotoxic reactive oxygen species (ROS) within the tumour. In addition to directly acting on tumour cells, PDT damages and restricts tumour microvasculature, and causes a local inflammatory response that stimulates an immune response against the tumour. Unlike surgery or radiotherapy, the surrounding extracellular matrix is unaffected by PDT; thus, tissue healing is excellent and PDT seldom causes scars...
March 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29467953/meta-analysis-of-a-10-plex-urine-based-biomarker-assay-for-the-detection-of-bladder-cancer
#13
Norihiko Masuda, Osamu Ogawa, Meyeon Park, Alvin Y Liu, Steve Goodison, Yunfeng Dai, Landon Kozai, Hideki Furuya, Yair Lotan, Charles J Rosser, Takashi Kobayashi
A 10-plex urine-based bladder cancer (BCa) diagnostic signature has the potential to non-invasively predict the presence of BCa in at-risk patients, as reported in various case-control studies. The present meta-analysis was performed to re-evaluate and demonstrate the robustness and consistency of the diagnostic utility of the 10-plex urine-based diagnostic assay. We re-analyzed primary data collected in five previously published case-control studies on the 10-plex diagnostic assay. Studies reported the sensitivity and specificity of ten urinary protein biomarkers for the detection of BCa, including interleukin 8, matrix metalloproteinases 9 and 10, angiogenin, apolipoprotein E, syndecan 1, alpha-1 antitrypsin, plasminogen activator inhibitor-1, carbonic anhydrase 9, and vascular endothelial growth factor A...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29334289/the-extracellular-matrix-degrading-protein-adamts5-is-expressed-in-the-nuclei-of-urothelial-cells-in-healthy-rats
#14
Dick Delbro, Lena Hallsberg, Ralph Peeker, Nikolai Scherbak, Magnus Fall, Rebecka Arnsrud Godtman
OBJECTIVE: The aim of this study was to investigate whether protein expression of the extracellular matrix-degrading protease ADAMTS5 can be demonstrated in the urinary bladder of healthy rats, and, if so, to determine the localization of this enzyme. MATERIALS AND METHODS: The experiments were conducted with eight inbred male Sprague-Dawley rats. Immunohistochemistry was used to investigate the expression of ADAMTS5 in the urinary bladder. Negative controls were established by either excluding the primary antibody or applying the antibody after it had been preabsorbed with its immunogenic peptide...
January 15, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29332824/dithiothreitol-based-protein-equalization-technology-to-unravel-biomarkers-for-bladder-cancer
#15
J E Araújo, H López-Fernández, M S Diniz, Pedro M Baltazar, Luís Campos Pinheiro, Fernando Calais da Silva, Mylène Carrascal, Paula Videira, H M Santos, J L Capelo
This study aimed to assess the benefits of dithiothreitol (DTT)-based sample treatment for protein equalization to assess potential biomarkers for bladder cancer. The proteome of plasma samples of patients with bladder carcinoma, patients with lower urinary tract symptoms (LUTS) and healthy volunteers, was equalized with dithiothreitol (DTT) and compared. The equalized proteomes were interrogated using two-dimensional gel electrophoresis and matrix assisted laser desorption ionization time of flight mass spectrometry...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29328441/ubenimex-an-apn-inhibitor-could-serve-as-an-anti%C3%A2-tumor-drug-in-rt112-and-5637-cells-by-operating-in-an-akt%C3%A2-associated-manner
#16
Xiaoqing Wang, Yang Liu, Wei Liu, Yongfei Zhang, Feng Guo, Lijuan Zhang, Mingyu Cui, Shuai Liu, Rongde Wu
Bladder cancer, a common urinary tract tumor, has high mortality and recurrence rates associated with metastasis. Aminopeptidase N (APN) expression and metastasis have been indicated to be associated with one another. Ubenimex may function as an APN inhibitor to inhibit the degradation of the extracellular matrix during tumorigenesis. Furthermore, APN has been widely used as an adjuvant therapy for the treatment of tumors; however, little information is available regarding the impact of ubenimex on patients...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29240612/extracellular-matrix-applications-in-the-treatment-of-open-fractures-with-complex-wounds-and-large-soft-tissue-defects
#17
Alexander A Fokin, Ivan Puente, Nir Hus, Eugenio Rodriguez, Russell D Weisz
Use of biologic scaffolds such as extracellular matrix (ECM) is a promising trend in the treatment of complex wounds in orthopedic trauma patients. In this clinical series we describe the technique of the successful application of porcine urinary bladder ECM products in the treatment of open fractures of the extremities with complex wounds and large soft tissue defects. The clinical outcomes demonstrated that even in challenging cases where local flap coverage of bone or neurovascular structures is not possible, sequential xenograft implantation allowed us to achieve a stable soft tissue envelope...
February 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29207636/characterization-of-urinary-extracellular-vesicle-proteins-in-muscle-invasive-bladder-cancer
#18
Christopher R Silvers, Hiroshi Miyamoto, Edward M Messing, George J Netto, Yi-Fen Lee
The mechanisms of bladder cancer progression are unknown, and new treatments and biomarkers are needed. Patient urinary extracellular vesicles (EVs) derive in part from bladder cancer cells and contain a specific protein cargo which may provide information about the disease. We conducted a proteomics study comparing EVs from the muscle-invasive bladder cancer (MIBC) cell line TCCSUP to EVs from normal urothelial line SVHUC. GO term analysis showed that TCCSUP EVs are enriched in proteins associated with the cell membrane, extracellular matrix, and inflammation and angiogenesis signaling pathways...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133168/autologous-granulation-tissue-tubes-for-replacement-of-urethral-defects-an-experimental-study-in-male-rabbits
#19
Shi-Wei Jiang, Zhong-Hua Xu, Yuan-Yuan Zhao, Lei Yan, Zun-Lin Zhou, Gang-Li Gu
INTRODUCTION: Tubularized urethroplasty is commonly performed in clinical practice using genital skin flaps, bladder mucosa, and buccal mucosa. However, the long-term effects are not satisfying, and donor site morbidities remain a problem. Besides, those grafts are unavailable with malignant conditions of the urinary tract, a history of lichen sclerosis, or oral disease. OBJECTIVE: An autologous granulation tissue tube of any required length and diameter can be produced by implanting foreign objects subcutaneously (Summary Fig...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29109844/porcine-urinary-bladder-extracellular-matrix-for-the-salvage-of-fibula-free-flap-skin-paddle-technical-note-and-description-of-a-case
#20
REVIEW
Rabie M Shanti, Ryan J Smart, Andrew Meram, David Kim
This report establishes a novel application of a commercially available porcine urinary bladder extracellular matrix, MatriStem (ACell, Inc., Columbia, MD), in the salvage of partial loss of the skin paddle of a fibula osteoseptocutaneous free flap that was utilized for mandibular reconstruction.
December 2017: Craniomaxillofacial Trauma & Reconstruction
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