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https://www.readbyqxmd.com/read/28791060/outcome-of-single-piece-intraocular-lens-sulcus-implantation-following-posterior-capsular-rupture-during-phacoemulsification
#1
Masomeh Mohebbi, Seyed Ali Bashiri, Seyed Farzad Mohammadi, Behnaz Samet, Fariba Ghassemi, Elham Ashrafi, Fatemeh Bazvand
PURPOSE: To assess the safety and outcome of single-piece posterior chamber intraocular lens (PC-IOL) implantation in the ciliary sulcus following posterior capsular rupture during cataract surgery. METHODS: Patients with posterior capsular rupture during cataract surgery with a single-piece acrylic IOL implanted into the ciliary sulcus were studied. Complete ocular examinations were performed after 6 months postoperatively. RESULTS: Twenty-four eyes were included...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28757700/brachytherapy-and-anterior-segment-imaging-in-iris-melanoma
#2
Jin Soo Andy Song, Adam A Dmytriw, Hesham Lakosha
Ultrasound biomicroscopy (UBM) remains a potent tool in the diagnosis and characterization of uveal lesions. In the setting of malignancy, it can confirm both placement of and response to brachytherapy. We present a case of iris melanoma with aggressive BAP-1 mutation, treated successfully with I-131 brachytherapy which was both characterized and followed with UBM and thereafter discuss the current state of these modalities.
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28736160/withdrawn-macrophage-phenotype-in-response-to-ecm-bioscaffolds
#3
Luai Huleihel, Jenna L Dziki, Joseph G Bartolacci, Theresa Rausch, Michelle E Scarritt, Madeline C Cramer, Tatiana Vorobyov, Samuel T LoPresti, Ilea T Swineheart, Lisa J White, Bryan N Brown, Stephen F Badylak
No abstract text is available yet for this article.
July 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28710279/ubmes-and-ubfluor-novel-probes-for-rbr-e3-ubiquitin-ligase-parkin
#4
Sungjin Park, Peter K Foote, David T Krist, Sarah E Rice, Alexander V Statsyuk
Ring-Between-Ring (RBR) E3 ligases have been implicated in autoimmune disorders and neurodegenerative diseases. The functions of many RBR E3s are poorly defined and their regulation is complex, involving posttranslational modifications and allosteric regulation with other protein partners. The functional complexity of RBRs, coupled with the complexity of the native ubiquitination reaction that requires ATP, E1, and E2 enzymes, makes it difficult to study these ligases for basic research and therapeutic purposes...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28704130/scleral-thinning-documented-by-ultrasound-biomicroscopy-after-plaque-therapy-for-anterior-ciliary-melanoma
#5
B Kuzmanović Elabjer, M Bušić, D Miletić, M Bjeloš, N Vukojević, D Bosnar
PURPOSE: To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma. METHODS: Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation with a radiation dose at the tumor apex of 80-100 Gy. UBM measurements performed prior to and after treatment were as follows: the largest prominence of the tumor perpendicular to the sclera and scleral thickness at scleral spur, 1...
July 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28696173/multimodal-imaging-in-anterior-uveitis
#6
Jay Siak, Padmamalini Mahendradas, Soon-Phaik Chee
Anterior uveitis is the most common group of uveitis worldwide, with a diverse spectrum ranging from autoimmune and infectious to masquerade etiologies. Elucidation of the underlying etiology may be challenging, but it remains important, especially for recurrent uveitis. Multimodal imaging has improved our understanding and management of many posterior uveitis and panuveitis. Similarly, a wide variety of anterior segment ophthalmic imaging techniques are available to allow the monitoring of the structural changes that may develop during anterior uveitis...
June 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28676726/-traumatic-cyclodialysis-treated-with-cryopexy
#7
P Plaza Ramos, H Heras Mulero, J I Molinuevo Ruiz de Zárate, C Abascal Azanza
yclodialysis is the result of the separation of the longitudinal fibres of the ciliary muscle from their scleral insertion, creating states of ocular hypotony. It is mainly caused by traumatisms. Gonioscopy has traditionally been the diagnostic test for this entity, however, at present it is being replaced by other techniques, such as ultrasound biomicroscopy (UBM). We present the case of a 57-year-old male who, following a traumatism in the left eye caused by the disc of a radial saw, presented corneal perforation and vitreous haemorrhage with pan-retinal edema...
June 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28660185/dedifferentiated-chondrocytes-in-composite-microfibers-as-tool-for-cartilage-repair
#8
Marco Angelozzi, Letizia Penolazzi, Stefania Mazzitelli, Elisabetta Lambertini, Andrea Lolli, Roberta Piva, Claudio Nastruzzi
Tissue engineering (TE) approaches using biomaterials have gain important roles in the regeneration of cartilage. This paper describes the production by microfluidics of alginate-based microfibers containing both extracellular matrix (ECM)-derived biomaterials and chondrocytes. As ECM components gelatin or decellularized urinary bladder matrix (UBM) were investigated. The effectiveness of the composite microfibers has been tested to modulate the behavior and redifferentiation of dedifferentiated chondrocytes...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28654790/effect-of-phosphate-amendment-on-relative-bioavailability-and-bioaccessibility-of-lead-and-arsenic-in-contaminated-soils
#9
Shi-Wei Li, Xue Liu, Hong-Jie Sun, Meng-Ya Li, Di Zhao, Jun Luo, Hong-Bo Li, Lena Q Ma
Hand-to-mouth activity is an important pathway for children's exposure to contaminated soils, which is often co-contaminated by Pb and As in mining and smelting sites. To reduce soil Pb risk to humans by oral exposure, phosphate amendments have been used to reduce Pb relative bioavailability (RBA), but its efficiency has not been investigated using validated in vitro assays nor its influence on As-RBA. Here, 5 contaminated soils (A-E) were amended with 0.5% phosphoric acid (PA) to study its effect on Pb- and As- RBA using a newly-developed mouse kidney model and bioaccessibility using 4 in vitro assays including UBM, SBRC, IVG, and PBET...
June 21, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28650876/the-role-of-imaging-in-strabismus
#10
Jinali R Patel, Kammi B Gunton
PURPOSE OF REVIEW: To review the most recent literature regarding the clinical experience of imaging modalities in strabismus. RECENT FINDINGS: MRI of extraocular muscles (EOMs) has elucidated the roles of variation in compartmental contraction of EOMs and further evidence of EOM pulley heterotopy in various strabismus patterns, which may contribute to the clinical and surgical management of patients as this mode of imaging becomes more readily available. Ultrasound biomicroscopy (UBM) and anterior-segment optical coherence tomography (AS-OCT) may play a role in determining the location of EOMs which could also aid in devising a preoperative surgical plan, especially in those who have had prior strabismus surgery...
June 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28634932/preparation-of-decellularized-biological-scaffolds-for-3d-cell-culture
#11
Bryan N Brown, Michael J Buckenmeyer, Travis A Prest
The biggest challenge of designing and implementing an in vitro study is developing a microenvironment that most closely represents the interactions observed in vivo. Decellularization of tissues and organs has been shown to be an effective method for the removal of potentially immunogenic constituents while preserving essential growth factors and extracellular matrix (ECM ) proteins necessary for proper cell function. Enzymatic digestion of decellularized tissues allows these tissue-specific components to be reconstituted into bioactive hydrogels through a physical crosslinking of collagen...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28613427/clinical-anatomy-of-the-anterior-chamber-angle-in-congenital-aniridia-and-consequences-for-trabeculotomy-cyclophotocoagulation
#12
Arne Viestenz, Berthold Seitz, Eva Deland, Miltiadis Fiorentzis, Lorenz Latta, Anja Viestenz, Barbara Käsmann-Kellner
INTRODUCTION: Intraocular pressure (IOP) lowering surgery in congenital aniridia glaucoma (CAG) can be complicated by dysgenesis of the limbal region, anterior chamber angle, iris and lens. METHODS: The anterior segments of 23 eyes (17 patients) with congenital aniridia were investigated under general anesthesia using ultrasound biomicroscopy (UBM). The structures of the anterior segment were examined: distance of ciliary body processes from the anterior chamber angle and positioning of Schlemm's canal...
June 14, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28602325/pigment-dispersion-syndrome-and%C3%A2-pigmentary-glaucoma-after-secondary-sulcus-transscleral-fixation-of-single-piece-foldable%C3%A2-posterior-chamber-intraocular-lenses%C3%A2-in%C3%A2-chinese-aphakic-patients
#13
Nianting Tong, Fuling Liu, Ting Zhang, Liangyu Wang, Zhanyu Zhou, Huimin Gong, Fuxiang Yuan
PURPOSE: To describe secondary pigment dispersion syndrome (PDS) and pigmentary glaucoma after secondary sulcus transscleral fixation of 1-piece hydrophobic acrylic foldable posterior chamber intraocular lenses (PC IOLs) in aphakic patients in a Chinese population. SETTING: Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao, China. DESIGN: Retrospective case series. METHODS: This chart review included eyes that had secondary sulcus transscleral fixation of a 1-piece hydrophobic acrylic foldable PC IOL (Tecnis ZCB00) between March 2011 and March 2014...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28583764/proteomic-composition-and-immunomodulatory-properties-of-urinary-bladder-matrix-scaffolds-in-homeostasis-and-injury
#14
REVIEW
Kaitlyn Sadtler, Sven D Sommerfeld, Matthew T Wolf, Xiaokun Wang, Shoumyo Majumdar, Liam Chung, Dhanashree S Kelkar, Akhilesh Pandey, Jennifer H Elisseeff
Urinary bladder matrix (UBM) is used clinically for management of wounds and reinforcement of surgical soft tissue repair, among other applications. UBM consists of the lamina propria and basal lamina of the porcine urinary bladder, and is decellularized as part of the process to manufacture the medical device. UBM is composed mainly of Collagen I, but also contains a wide variety of fibrillar and basement membrane collagens, glycoproteins, proteoglycans and ECM-associated factors. Upon application of the biomaterial in a traumatic or non-traumatic setting in a mouse model, there is a cascade of immune cells that respond to the damaged tissue and biomaterial...
June 2, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28582742/bioaccessibility-of-pahs-in-contaminated-soils-comparison-of-five-in-vitro-methods-with-tenax-as-a-sorption-sink
#15
Shujun Zhang, Chao Li, Yunzi Li, Ruirui Zhang, Peng Gao, Xinyi Cui, Lena Q Ma
For hydrophobic organic contaminants, physiologically based in vitro methods may need to include a sorption sink to simulate in vivo intestinal uptake. We compared PAH bioaccessibility in contaminated soils using five in vitro methods including physiologically based extraction test (PBET), in vitro digestion assay (IVD), method from Deutsches Institut für Normung (DIN), unified bioaccessibility method (UBM), and fed organic estimation human simulation test (FOREhST) in the absence and presence of Tenax as a sorption sink...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28580550/magnetic-signature-geochemistry-and-oral-bioaccessibility-of-technogenic-metals-in-contaminated-industrial-soils-from-sindos-industrial-area-northern-greece
#16
Anna Bourliva, Lambrini Papadopoulou, Elina Aidona, Katerina Giouri
The objective of this study was to assess the contamination level of potentially harmful elements (PHEs) in industrial soils and how this relates to environmental magnetism. Moreover, emphasis was given to the determination of the potential mobile fractions of typically "technogenic" metals. Therefore, magnetic and geochemical parameters were determined in topsoils (0-20 cm) collected around a chemical industry in Sindos Industrial Area, Thessaloniki, Greece. Soil samples were presented significantly enriched in "technogenic" metals such Cd, Pb, and Zn, while cases of severe soil contamination were observed in sampling sites north-west of the industrial unit...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28515637/ultrasound-biomicroscopy-value-in-evaluation-of-restoration-of-ciliary-muscles-contractility-after-cataract-extraction
#17
Ayser Abd El-Hameed Fayed
PURPOSE: To assess the changes in the contractility of the ciliary muscle in eyes with presbyopia before and after phacoemulsification and intracapsular lens implantation using ultrasound biomicroscopy (UBM). PATIENTS AND METHODS: This prospective study included 50 eyes of 30 consecutive subjects operated at the Department of Ophthalmology. Patients with any ocular disorder affecting visual acuity, corneal surface irregularities, had posterior capsular perforation or intensive postoperative corneal edema, or were <35 years of age, were excluded...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28506460/mechanisms-of-ubiquitin-nucleosome-recognition-and-regulation-of-53bp1-chromatin-recruitment-by-rnf168-169-and-rad18
#18
Qi Hu, Maria Victoria Botuyan, Gaofeng Cui, Debiao Zhao, Georges Mer
The protein 53BP1 plays a central regulatory role in DNA double-strand break repair. 53BP1 relocates to chromatin by recognizing RNF168-mediated mono-ubiquitylation of histone H2A Lys15 in the nucleosome core particle dimethylated at histone H4 Lys20 (NCP-ubme). 53BP1 relocation is terminated by ubiquitin ligases RNF169 and RAD18 via unknown mechanisms. Using nuclear magnetic resonance (NMR) spectroscopy and biochemistry, we show that RNF169 bridges ubiquitin and histone surfaces, stabilizing a pre-existing ubiquitin orientation in NCP-ubme to form a high-affinity complex...
May 18, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28489273/low-level-light-minoxidil-5-combination-versus-either-therapeutic-modality-alone-in-management-of-female-patterned-hair-loss-a-randomized-controlled-study
#19
Samia M Esmat, Rehab A Hegazy, Heba I Gawdat, Rania M Abdel Hay, Riham S Allam, Rofaida El Naggar, Hoda Moneib
BACKGROUND: Female pattern hair loss (FPHL) is the most common form of hair loss in women. Nevertheless, its management represents a real challenge. Among the FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT). AIM OF WORK: Assess the efficacy and safety of LLLT in comparison to topical minoxidil 5% and to a combination of both therapies in the treatment of FPHL. PATIENTS AND METHODS: This study included 45 female patients with proven FPHL...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28487752/brachytherapy-and-anterior-segment-imaging-in-iris-melanoma
#20
Jin Soo Andy Song, Adam A Dmytriw, Hesham Lakosha
A 40-year-old male presented to the ophthalmology clinic with a darkly pigmented infratemporal lesion in his right eye. The corrected visual acuity in both eyes was 6/6 and both pupils were equal and reactive. Slit lamp biomicroscopy showed a well-demarcated and heavily pigmented lesion in the peripheral iris between 6 and 8 o'clock. Ultrasound biomicroscopy (UBM) revealed a solid mass deriving from the iris stroma without ciliary body involvement, helping to classify the uveal melanoma and establishing the diagnosis of iris melanoma...
2017: Ecancermedicalscience
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