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Abdulaziz Anazi Alshamrani, Sami Al-Shahwan
BACKGROUND: Crouzon syndrome is the most common form of craniosynostosis, and mutations in the fibroblast growth factor receptor 2 and 3 (FGFR2 and FGFR3) genes are implicated in its pathogenesis. OBSERVATION: A 10-year-old female patient with Crouzon syndrome and congenital glaucoma treated with trabeculectomy and ocular hypotensive medications was examined. The patient had proptosis, exposure keratopathy, megalocornea, thin central corneal thickness, a shallow anterior chamber, mild anterior subcapsular cataract, and a cup-to-disc ratio of 0...
March 19, 2018: Journal of Glaucoma
Azam Qureshi, Haoxing Chen, Osamah Saeedi, Mona A Kaleem, Gianna Stoleru, Jordan Margo, Sachin Kalarn, Janet L Alexander
PURPOSE: In this novel study, we demonstrate a standardized imaging and measurement protocol of anterior segment (AS) structures with reliability analysis using ultrasound biomicroscopy (UBM) and ImageJ software. METHODS: Ten pediatric and young adult patients undergoing examination under anesthesia for AS pathology were imaged using UBM. Four trained observers analyzed 20 images using ImageJ. Forty-five structural parameters were measured. Those that relied on the trabecular-iris angle (TIA) as a reference landmark were labeled TIA-dependent (TD) and all others were labeled non-TIA dependent (NTD)...
March 7, 2018: International Ophthalmology
Vasile Potop, Catalina Corbu
Clear lens extraction can be considered a therapeutic option in angle closure glaucoma (ACG). Even if it does not represent the first choice of treatment, it can be taken into consideration when the topical treatment does not control the intraocular pressure (IOP) and iridotomy does not have a positive effect on the angle closure, especially in appositional angle closure when biometry or ultrabiomicroscopy (UBM) show lens involvement. In angle closure glaucoma, clear lens extraction represents an etiological treatment that takes into account the role of the lens in the pathogenesis of the disease...
October 2017: Romanian Journal of Ophthalmology
Nikolaos Mamas, Konstantinos Andreanos, Dimitrios Brouzas, Andreas Diagourtas, Andreas Droulias, Ilias Georgalas, Dimitrios Papaconstantinou
PURPOSE: To report the case of a 65-year-old metalworker with no known history of ocular trauma, who suffered from intense ocular pain during magnetic resonance imaging (MRI) of the brain, due to a retained intraocular metallic foreign body (IOFB). CASE REPORT: Meticulous ophthalmological examination was inconclusive. An IOFB was confirmed with X-ray scan, whereas its exact localization was enabled by means of ultrasonography and ultrasound biomicroscopy (UBM). CONCLUSIONS: Despite appropriate screening protocols, MRI-related ocular complications might occur in the presence of a hidden metallic IOFB...
March 2, 2018: Journal of Ultrasound
Xingyi Li, Wei Wang, Wenbin Huang, Shida Chen, Jiawei Wang, Zhonghao Wang, Yaoming Liu, Mingguang He, Xiulan Zhang
PURPOSE: To measure the anterior and posterior ocular biometric characteristics concurrently and to explore the relationship between iris, ciliary body and choroid in acute primary angle closure eyes (APAC) and fellow eyes. METHODS: It is a prospective, cross-sectional study. Thirty patients with recent APAC were finally enroled in it. Anterior and posterior uveal parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), swept-source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM)...
March 1, 2018: Eye
Ali Abbas El Salhy, Rabab Mohamed Elseht, Ahmed Fekry Al Maria, Saied Mohamed Abd El-Wahab Shalaby, Tarek Ragaee Hossein
AIM: To study the role of ultrasound biomicroscopy (UBM) in the assessment of the bleb function after trabeculectomy with mitomycin C (MMC). METHODS: This was a cross-sectional study including all cases had undergone trabeculectomy with MMC 0.2 mg/mL for 3min. Participants were recruited from the follow-up cases at Department of Ophthalmology, Tanta University in the period from August 2015 to August 2016. Full history taking and ophthalmological examination were performed...
2018: International Journal of Ophthalmology
Abhidnya Surve, Rachna Meel, Neelam Pushker, M S Bajaj
Purpose: To study the features of upper eyelid in healthy individual and different types of congenital ptosis in the Indian population using ultrasound biomicroscopy (UBM). Methods: This was a prospective observational study at a tertiary care center. Eyelid structure of healthy individuals with no eyelid abnormalities (n = 19); simple congenital ptosis (n = 33) cases; Marcus Gunn jaw-winking ptosis (MGJWP, n = 7) cases, and blepharophimosis-ptosis-epicanthus inversus syndrome (BPES, n = 20) cases were studied on a vertical UBM scan using 50-MHz probe...
March 2018: Indian Journal of Ophthalmology
Peter Meyer, Elisabeth Graeff, Corina Kohler, Francis Munier, Elisabeth Bruder
Purpose: To report a case of juvenile xanthogranuloma involving the iris and skin that clincally was diagnosed with an obvious cutaneous lesion. Observations: A four month-old girl with hyphema and increased intraocular pressure of the left eye persisting for 2 weeks. A suspicious yellow-brown mass with nodular surface and traversed by irregular vascularization was noted on the inferior iris surface. Ultrasound biomicroscopy (UBM; 35 MHz) of the mass revealed multiple nodular irregular hyperreflective lesions in the peripheral iris...
March 2018: American Journal of Ophthalmology Case Reports
Eszter Vizvári, Ákos Skribek, Nóra Polgár, András Vörös, Pál Sziklai, Edit Tóth-Molnár
PURPOSE: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi...
2018: PloS One
Eva Martín-Suárez, Alba Galán, Juan Morgaz, Alicia Guisado, José María Gallardo, Rafael Jesús Gómez-Villamandos
Ultrasound pachymetry (UP) is currently the most common technique used to evaluate central corneal thickness (CCT). New devices which allow assessment of CCT without corneal contact have been compared, but there are discrepancies among instruments. The aim of this study was to compare CCT measurements obtained by UP and ultrasound biomicroscopy (UBM) in 28 eyes of 14 healthy Beagles dogs. Mean CCT±standard deviation (SD) were 552±63μm for UP and 551±55μm for UBM. UBM showed both a fixed and proportional bias when compared to ultrasound pachymetry, but this was not considered to be clinically important...
February 2018: Veterinary Journal
Bozho Todorich, Lisa J Faia, Aristomenis Thanos, Mitual Amin, Robert Folberg, Jeremy D Wolfe, Krista M Todorich, Efthemios Raphtis, Alan J Ruby, George A Williams, Tarek S Hassan
PURPOSE: To derive novel insights into the pathophysiology of vancomycin-related hemorrhagic occlusive retinal vasculopathy (HORV) through a careful clinicopathologic correlation. METHODS: and study design: We retrospectively reviewed the clinical and pathologic course of two consecutive patients who developed HORV. The clinical history, multimodal imaging, ultrasound biomicroscopy (UBM), intraoperative and histological findings are reported. RESULTS: Both patients presented with decreased vision and eye pain within 1 week following otherwise uncomplicated cataract extraction and were diagnosed with HORV after endophthalmitis was ruled out...
February 6, 2018: American Journal of Ophthalmology
Rupinder Chahal, Abhijit Anand Mohite, Heinrich Heimann, Atul Bansal
PURPOSE: We report a previously unrecognised mechanism of secondary glaucoma due to iridescent crystalline particles released from an irradiated iris melanoma. It masqueraded as refractory hypertensive uveitis following uncomplicated phacoemulsification. METHODS: A 58-year-old gentleman had an iris melanoma that underwent successful regression following irradiation with proton beam radiotherapy (PBRT). Three years later an uncomplicated phacoemulsification with intraocular lens implant was performed and subsequently the patient presented with apparently "refractory hypertensive uveitis"...
February 1, 2018: Journal of Glaucoma
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa
BACKGROUND: Spontaneous formation of subconjunctival filtering blebs is rare and has been observed after penetrating ocular surgery, in association with connective tissue diseases and inflammatory conditions. METHOD: We describe here a case of a spontaneous formation of subconjunctival filtering bleb as sequelae of gonococcal conjunctivitis in an adult patient. RESULTS: Spontaneous filtering bleb is a rare complication of gonococcal conjunctivitis...
January 18, 2018: Irish Journal of Medical Science
Eugen Pfeifer, Cornelia Gätgens, Tino Polen, Julia Frunzke
In this work, we performed a comparative adaptive laboratory evolution experiment of the important biotechnological platform strain Corynebacterium glutamicum ATCC 13032 and its prophage-free variant MB001 towards improved growth rates on glucose minimal medium. Both strains displayed a comparable adaptation behavior and no significant differences in genomic rearrangements and mutation frequencies. Remarkably, a significant fitness leap by about 20% was observed for both strains already after 100 generations...
December 1, 2017: Scientific Reports
David Kuerten, Niklas Plange, Jakob Becker, Peter Walter, Matthias Fuest
BACKGROUND: To analyze long-term structural changes in conjunctiva, sclera and Schlemm canal (SC) with anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) following uncomplicated canaloplasty. MATERIALS AND METHODS: Fifteen patients with planned canaloplasty and no intraoperative complications were included in this prospective study. AS-OCT images were acquired at 1, 3, 6 months and at a long-term time point (20±4.9 mo) postsurgery...
January 2018: Journal of Glaucoma
Yan Zhang, Chao Wang, Li Liu, Yingqing Lei, Yue He, Ling Yu
PURPOSE: To describe the ultrasound biomicroscopy (UBM) and B-scan ultrasonography findings and therapeutic approach for ciliochoroidal detachment secondary to acute primary angle-closure glaucoma (APACG) in four patients. We also reviewed the literature. METHODS: Case report and systematic literature review. RESULTS: The four patients were referred to our department for further management of APACG. The UBM and B-scan ultrasonography examinations were conducted 2 days after the beginning of medical treatment and demonstrated ciliochoroidal detachment in four eyes of the four patients...
November 23, 2017: International Ophthalmology
Aurélie Pelfrêne, Francis Douay
Soil and dust contamination by metals engenders significant environmental and health problems in northern France where a lead smelter was in activity for more than a century. This study aims to examine the long-term effects of the smelter, 10 years after its closedown, on the presence of metal in sidewalk dust for a better assessment of the local population's exposure to Cd and Pb. The investigation included: (i) the metal distribution in different dust particle sizes and (ii) the assessment of metal bioaccessibility via ingestion and inhalation of dust...
November 22, 2017: Environmental Science and Pollution Research International
Julio Daniel Grigera, Emilio Daniel Grigera
We report a case of a 49-year-old female who presented to the emergency department with blurred vision and vomiting, hours after taking two tablets of 250 mg of acetazolamide. The anterior chamber was bilaterally flat, with normal intraocular pressure in both eyes. An ultrasound biomicroscopic (UBM) examination showed bilateral ciliary effusion and complete appositional angle closure in all quadrants. Acetazolamide-induced bilateral angle closure was diagnosed. Steroid and cycloplegic therapy were initiated, and acetazolamide was discontinued...
September 2017: Arquivos Brasileiros de Oftalmologia
Joel M Mor, Konrad R Koch, Ludwig M Heindl
The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. The timely identification of malignant lesions (i...
December 2017: Klinische Monatsblätter Für Augenheilkunde
Tarannum Mansoori, Nagalla Balakrishna
Aim: To evaluate the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI). Materials and methods: A total of 185 eyes of 185 PACG patients post-LPI and 126 eyes of 126 normal subjects were included in this prospective study. All subjects underwent complete ophthalmic evaluation, A-scan biometry, and UBM...
September 2017: Journal of Current Glaucoma Practice
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