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Acell, Inc.

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https://www.readbyqxmd.com/read/27681811/a-comparative-analysis-of-skin-substitutes-used-in-the-management-of-diabetic-foot-ulcers
#1
M Martinson, N Martinson
OBJECTIVE: To compare the relative product cost and clinical outcomes of four skin substitutes used as adjunctive treatments for diabetic foot ulcers (DFUs). METHOD: Medicare claims data from 2011 to 2014 were used to identify beneficiaries with diabetes and foot ulcers. Patients treated with one of four types of skin substitute (Apligraf, Dermagraft, OASIS, and MatriStem) were identified. The skin substitutes were compared on episode length; amputation rate; skin substitute utilisation; and skin substitute costs...
October 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27486495/case-report-cardiac-tumor-resection-and-repair-with-porcine-xenograft
#2
Walid K Abu Saleh, Odeaa Al Jabbari, Basel Ramlawi, Brian A Bruckner, Matthias Loebe, Michael J Reardon
Primary cardiac sarcomas are rare and carry a grave prognosis. Improved survival requires a complete margin negative resection of the tumor. These surgical resections are often large and complex, requiring extensive reconstructive procedures. The appropriate material for cardiac reconstruction is not known. We have used glutaraldehyde-fixed bovine pericardium in our early series but have recently employed the MatriStem(®) Surgical Matrix PSMX membrane (ACell(®), Inc.; Columbia, MD), a unique proprietary urinary bladder matrix derived from porcine urinary bladder with the potential for viability and tissue ingrowth...
April 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/27372297/novel-use-of-porcine-urinary-bladder-matrix-for-pediatric-pilonidal-wound-care-preliminary-experience
#3
Robert M Dorman, Kathryn D Bass
BACKGROUND: Extracellular matrix is used in various applications. We present our preliminary experience using a new device that consists of a porcine extracellular matrix with an epithelial basement membrane (MatriStem(®), ACell, Inc. Columbia, MD, USA) for adolescent pilonidal disease. METHODS: A retrospective review of four patients with pilonidal disease was undertaken. Three occurred in the gluteal cleft, and the fourth in the umbilicus. In the first patient, the wound deficit was filled with lyophilized MicroMatrix powder and a sheet of Multilayer Wound Matrix was placed to cover the wound...
October 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27178506/novel-treatment-of-a-septal-ulceration-using-an-extracellular-matrix-scaffold-septal-ulceration-treatment-using-ecm
#4
Yi-Chun Carol Liu, Nipun Chhabra, Steven M Houser
BACKGROUND: Septal ulceration is a mucositis involving the mucous membranes of the nasal septum. Patients often complain of nasal irritation, crusting, and epistaxis. Presently, there is no gold standard for the treatment of septal ulcerations. Currently described therapies include local debridement, septal dermoplasty, septal flap reconstruction, and cadaveric dermal graft repair; however, no therapy has demonstrated a consistent improvement of symptoms. We present a novel approach for the treatment of chronic septal ulceration, using an extracellular matrix scaffold (MatriStem® Wound Care Matrix, ACell, Inc...
May 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/26978800/the-use-of-a-novel-canister-free-negative-pressure-device-in-chronic-wounds-a-retrospective-analysis
#5
Thomas E Serena, John S Buan
OBJECTIVE: Negative-pressure wound therapy (NPWT) is a mainstay in the treatment of acute and chronic wounds. Following the success of the Vacuum-Assisted Closure system (Kinetic Concepts Inc [KCI], an Acelity Company, San Antonio, Texas), many similar systems were developed with minor variations. However, these systems are best suited to wounds with soft-tissue defects. Moreover, the need for a canister to collect wound exudate adds to the size and weight of the device. A canister-free (CF) NPWT device was cleared by the FDA for the treatment of chronic wounds (Kalypto Medical, Mendota Heights, Minnesota)...
April 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/26866867/negative-pressure-therapy-to-reduce-the-risk-of-wound-infection-following-diverting-loop-ileostomy-reversal-an-initial-study
#6
Ramon Cantero, Ines Rubio-Perez, Miguel Leon, Mario Alvarez, Beatriz Diaz, Ana Herrera, Joaquin Diaz-Dominguez, Jose Antonio Rodriguez-Montes
OBJECTIVE: To evaluate if the application of a negative-pressure therapy system (Prevena Incision Management System, Kinetics Concepts Inc, [KCI] an Acelity Company, San Antonio, Texas) on ileostomy-closure surgical wounds would reduce surgical site infections (SSIs) in comparison with conventional closure and dressing. DESIGN: Prospective interventional pilot study. SETTING: La Paz University Hospital, tertiary care academic hospital in Madrid, Spain...
March 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/26075374/use-of-a-human-acellular-dermal-wound-matrix-in-patients-with-complex-wounds-and-comorbidities
#7
M L Williams, J E Holewinski
OBJECTIVE: Rising prevalence of obesity and uncontrolled diabetes mellitus has resulted in an increasing number of patients with multiple comorbidities who require treatment for chronic complex wounds. Because patients with diabetes and foot ulcers may have a higher risk for amputations, techniques that facilitate complex wound healing and prevent limb amputation are desirable. Here, we investigate a limb preservation strategy that includes application of a human acellular dermal wound matrix (HADWM)...
June 2015: Journal of Wound Care
https://www.readbyqxmd.com/read/25319574/esophageal-reinforcement-with-an-extracellular-scaffold-during-total-gastrectomy-for-gastric-cancer
#8
Cheguevara Afaneh, Jonathan Abelson, Mark Schattner, Yelena Y Janjigian, David Ilson, Sam S Yoon, Vivian E Strong
BACKGROUND: Esophagojejunal (EJ) anastomotic leaks after total gastrectomy (TG) for malignancy lead to significant morbidity and mortality, thus affecting long-term survival. Preclinical and clinical trials have shown promise in utilizing degradable extracellular matrix (ECM) scaffolds in buttressing anastomoses. We describe our experience buttressing the EJ anastomosis after TG with a ECM scaffold. METHODS: From February 2012 to January 2014, a total of 37 consecutive patients underwent TG buttressing of the EJ anastomosis with the degradable ECM scaffold composed of a porcine urinary bladder called MatriStem (ACell Inc...
April 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25119505/biomimetic-randall-s-plaque-as-an-in-vitro-model-system-for-studying-the-role-of-acidic-biopolymers-in-idiopathic-stone-formation
#9
Archana Chidambaram, Douglas Rodriguez, Saeed Khan, Laurie Gower
Randall's plaque (RP) deposits seem to be consistent among the most common type of kidney stone formers, idiopathic calcium oxalate stone formers. This group forms calcium oxalate renal stones without any systemic symptoms, which contributes to the difficulty of understanding and treating this painful and recurring disease. Thus, the development of an in vitro model system to study idiopathic nephrolithiasis, beginning with RP pathogenesis, can help in identifying how plaques and subsequently stones form. One main theory of RP formation is that calcium phosphate deposits initially form in the basement membrane of the thin loops of Henle, which then fuse and spread into the interstitial tissue, and ultimately make their way across the urothelium, where upon exposure to the urine, the mineralized tissue serves as a nidus for overgrowth with calcium oxalate into a stone...
January 2015: Urolithiasis
https://www.readbyqxmd.com/read/24045565/urinary-bladder-matrix-for-the-treatment-of-recalcitrant-nonhealing-radiation-wounds
#10
Elizabeth A Rommer, Mirna Peric, Alex Wong
Chronic wounds in previously radiated tissue are challenging to treat. In this article, the authors describe 3 such wounds that failed to heal despite multiple treatments with traditional wound healing methods. Treatment with porcine urinary bladder matrix, an extracellular matrix material, was initiated to facilitate epithelialization and promote wound healing. MatriStem powder (ACell, Inc, Columbia, Maryland), MatriStem (ACell, Inc) sheet, and DuoDerm (ConvaTec, Skillman, New Jersey) were applied biweekly and resulted in complete wound closure within 3 weeks of initial application for all 3 cases...
October 2013: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/11106289/use-of-diphtheria-toxoid-tetanus-toxoid-acellular-pertussis-vaccine-as-a-five-dose-series-supplemental-recommendations-of-the-advisory-committee-on-immunization-practices-acip
#11
(no author information available yet)
Four vaccines containing diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) are currently licensed in the United States for use among infants and young children. As of October 2000, two products, ACEL-IMUNE (a product of Lederle Laboratories) and Tripedia (Aventis Pasteur, Inc.) were licensed for the five-dose DTaP vaccination series. Two other vaccines, Infanrix (SmithKline Beecham Biologicals) and Certiva (North American Vaccine, Inc.) are licensed for the first four doses of the vaccination series, beginning with the primary series at ages 2, 4, and 6 months, and for completing the DTaP series among children who began the series with diphtheria and tetanus toxoids and whole-cell pertussis vaccine...
November 17, 2000: MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports
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