keyword
https://read.qxmd.com/read/38525679/loss-of-daylength-sensitivity-by-splice-site-mutation-in-cannabis-pseudo-response-regulator
#21
JOURNAL ARTICLE
Keegan M Leckie, Jason Sawler, Paul Kapos, John O MacKenzie, Ingrid Giles, Katherine Baynes, Jessica Lo, Gregory J Baute, Jose M Celedon
Photoperiod insensitivity (auto-flowering) in drug-type Cannabis sativa circumvents the need for short day (SD) flowering requirements making outdoor cultivation in high latitudes possible. However, the benefits of photoperiod insensitivity are counterbalanced by low cannabinoid content and poor flower quality in auto-flowering genotypes. Despite recent studies in cannabis flowering, a mechanistic understanding of photoperiod insensitivity is still lacking. We used a combination of genome-wide association study and genetic fine-mapping to identify the genetic cause of auto-flowering in cannabis...
March 25, 2024: Plant Journal
https://read.qxmd.com/read/38525330/kairos-study-protocol-a-multidisciplinary-approach-to-the-study-of-school-timing-and-its-effects-on-health-well-being-and-students-performance
#22
JOURNAL ARTICLE
Daniel Gabaldón-Estevan, Diego Carmona-Talavera, Belén Catalán-Gregori, Elena Mañas-García, Vanessa Martin-Carbonell, Lucía Monfort, Elvira Martinez-Besteiro, Mònica González-Carrasco, María Jesús Hernández-Jiménez, Kadri Täht, Marta Talavera, Ana Ancheta-Arrabal, Guillermo Sáez, Nuria Estany, Gonzalo Pin-Arboledas, Catia Reis
Recent evidence from chronobiology, chssronomedicine and chronopsychology shows that the organisation of social time (e.g., school schedules) generally does not respect biological time. This raises concerns about the impact of the constant mismatch between students' social and internal body clocks on their health, well-being and academic performance. The present paper describes a protocol used to investigate the problem of (de) synchronisation of biological times (chronotypes) in childhood and youth in relation to school times...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38524170/the-effect-of-chronotypes-on-follow-up-outcomes-of-patients-with-substance-use-disorder
#23
JOURNAL ARTICLE
Ozlem Akcay Ciner, Ali Savas Cilli, Ahmet Bulent Yazici, Hasan Bakay, Şakir Gica
Substance use disorder (SUD) can have circadian characteristics and individuals with evening chronotype are more prone to addiction. In this study, the effect of chronotypes on the treatment outcomes of SUD was investigated. The study included 66 patients who were diagnosed with SUD according to DSM-5. Two clinical interviews were conducted at 6-month intervals, and remission/relapse status was evaluated at the second interview. The Structured Clinical Interview Form for DSM-IV Axis I Disorders (SCID-I), Addiction Profile Index Practitioner Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburg Sleep Quality Index and Morningness-Eveningness Questionnaire (MEQ) were applied to the patients...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38524168/a-review-for-the-impacts-of-circadian-disturbance-on-urological-cancers
#24
REVIEW
Tao Li, Yiting Jiang, Yunjin Bai, Kehua Jiang, Guangshi Du, Peng Chen, Chao Luo, Lei Li, Jun Qiao, Jun Shen
Circadian rhythm is an internal timing system and harmonizes a variety of cellular, behavioral, and physiological processes to daily environment. Circadian disturbance caused by altered life style or disrupted sleep patterns inevitably contributes to various disorders. As the rapidly increased cancer occurrences and subsequent tremendous financial burdens, more researches focus on reducing the morbidity rather than treating it. Recently, many epidemiologic studies demonstrated that circadian disturbance was tightly related to the occurrence and development of cancers...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38524167/iris-color-and-day-night-changes-in-the-sympathovagal-ratio
#25
JOURNAL ARTICLE
Şahbender Koç, Aslı Enzel Koç
Iris melanocytes are innervated by parasympathetic and sympathetic nerve endings. Light affects autonomic nervous system activity via the retino-hypothalamic pathway. The hypothesis that the day-to-night variations in the sympatovagal ratio (LF/HF) may differ among individuals with different brown iris patterns was tested. A total of 621 healthy adults, aged between 16 and 50, with brown eyes and not diagnosed with a disease that might affect the autonomous nerve system were included in the study. A digital camera was used to acquire iris photos...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38524161/alterations-in-per2-bcl2-gene-expression-and-oxidative-status-in-aged-rats-liver-after-light-pulse-at-night
#26
JOURNAL ARTICLE
Rehab E El-Hennamy, Heba A Elmasry
The aging process is characterized by circadian rhythm disruption, in physiology and behavior, which could result from weak entrainment. Light is the most potent cue that entrains the central circadian clock, which in turn synchronizes peripheral clocks in animal tissues. Period 2 (Per2 ) is one of the clock genes that respond to light. Moreover, oxidative stress could entrain the clock. Therefore, the present work aimed to investigate the role of light when applied late at night on the Per2 , B cell lymphoma 2 ( Bcl2 ) gene expression, and oxidative status in aged rats...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38524157/estimating-dim-light-melatonin-onset-time-in-children-using-delta-changes-in-melatonin
#27
JOURNAL ARTICLE
Taisuke Eto, Shingo Kitamura, Akiko Shikano, Kosuke Tanabe, Shigekazu Higuchi, Shingo Noi
UNLABELLED: We aimed to establish a method for estimating dim light melatonin onset (DLMO) using mathematical slopes calculated from melatonin concentrations at three sampling points before and after sleep in children. The saliva of 30 children (mean age ± SD: 10.2 ± 1.3 years old) was collected under dim-light conditions up to six times every hour starting at 17:30 (t17), namely, 18:30 (t18), 19:30 (t19), 20:30 (t20), 21:30 (t21), 22:30 (t22), and 23:30 (t23), in the evening, and at 6:00 (t30) the following morning...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38523784/from-biological-data-to-oscillator-models-using-sindy
#28
JOURNAL ARTICLE
Bartosz Prokop, Lendert Gelens
Periodic changes in the concentration or activity of different molecules regulate vital cellular processes such as cell division and circadian rhythms. Developing mathematical models is essential to better understand the mechanisms underlying these oscillations. Recent data-driven methods like SINDy have fundamentally changed model identification, yet their application to experimental biological data remains limited. This study investigates SINDy's constraints by directly applying it to biological oscillatory data...
April 19, 2024: IScience
https://read.qxmd.com/read/38523502/-ergonomics-and-organization-of-remote-work-health-aspect-and-recommendations-for-home-office-organization
#29
JOURNAL ARTICLE
Magdalena Janc, Ewa Lipiec, Zbigniew Jóźwiak, Kinga Polańska, Teresa Makowiec-Dąbrowska
Analyses of the economic activity of the Polish population indicate that in 2023, about 7% of all employees performed, usually or sometimes, their work in the form of remote work. The purpose of this publication is to analyze the impact of working with screen-monitor devices on computer vision syndromes, musculoskeletal disorders, circadian rhythm, and to identify recommendations for the proper organization of the home office. A narrative review of the existing literature on the impact of work with the use of devices equipped with screen monitors on the health of employees was performed, as well as recommendations in the above-mentioned area were presented...
March 22, 2024: Medycyna Pracy
https://read.qxmd.com/read/38522517/mechanisms-generating-network-switches-and-their-role-in-circadian-clocks
#30
REVIEW
Marta Del Olmo, Stefan Legewie, Michael Brunner, Thomas Höfer, Achim Kramer, Nils Blüthgen, Hanspeter Herzel
Circadian rhythms are generated by complex interactions among genes and proteins. Self-sustained ∼24 hour oscillations require negative feedback loops and sufficiently strong nonlinearities that are the product of molecular and network switches. Here we review common mechanisms to obtain switch-like behavior, including cooperativity, antagonistic enzymes, multisite phosphorylation, positive feedback, and sequestration. We discuss how network switches play a crucial role as essential components in cellular circadian clocks, serving as integral parts of transcription-translation feedback loops (TTFLs) that form the basis of circadian rhythm generation...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38522403/circadian-rhythms-in-cyp2a5-expression-underlie-the-time-dependent-effect-of-tegafur-on-breast-cancer
#31
JOURNAL ARTICLE
Yuya Yoshida, Taiki Fukuda, Tomohito Tanihara, Naoki Nishikawa, Serina Iwasa, Satoka Adachi, Orion Zaitsu, Yuma Terada, Ryotaro Tsukamoto, Hideki Shimoshikiryo, Kohei Fukuoka, Fumiaki Tsurusaki, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
The chemotherapeutic agent tegafur, a prodrug that prolongs the half-life of fluorouracil (5-FU), exerts antitumor effects against various cancers. Since tegafur is metabolized to 5-FU by CYP2A6 in the liver, the expression of CYP2A6 determines the effect of tegafur. Here, we report that the expression rhythm of Cyp2a5, a homolog of human CYP2A6, in female mice causes dosing time-dependent differences in tegafur metabolism. In the livers of female mice, CYP2A5 expression showed a circadian rhythm, peaking during the dark period...
March 20, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38521925/development-validation-and-reliability-of-the-chrononutrition-profile-questionnaire-pregnancy-cpq-p
#32
JOURNAL ARTICLE
Ee Yin Kok, Satvinder Kaur, Nurul Husna Mohd Shukri, Nurliyana Abdul Razak, Masaki Takahashi
BACKGROUND: During pregnancy, physiological changes can affect eating and sleeping habits, which may eventually have negative consequences for maternal and foetal health. To better understand these changes, it is essential to develop a reliable questionnaire that addresses lifestyle habits such as snacking and daytime napping. This study aimed to determine the validity and reliability of the Chrononutrition Profile Questionnaire-Pregnancy (CPQ-P). METHODS: A total of 399 women in their second and third trimester of pregnancy were recruited from government maternal and child health clinics in Kuala Lumpur and Putrajaya and completed a self-administered online questionnaire...
March 23, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38521354/exposure-to-real-ambient-bedroom-light-at-night-delayed-circadian-rhythm-in-healthy-chinese-young-adults-a-cross-sectional-study
#33
JOURNAL ARTICLE
Yu-Xiang Xu, Yan Huang, Wen-Qin Ding, Yi Zhou, Yu-Ting Shen, Yu-Hui Wan, Pu-Yu Su, Fang-Biao Tao, Ying Sun
BACKGROUND: Light at night (LAN) have attracted increased research attention on account of its widespread health hazards. However, the underlying mechanism remains unknown. The objective of this study was to investigate the effects of real-ambient bedroom LAN exposure on circadian rhythm among young adults and potential sex differences. METHODS: Bedroom LAN exposure was measured at 60-s intervals for 2 consecutive days using a portable illuminance meter. Circadian phase was determined by the dim light melatonin onset (DLMO) time in 7 time-series saliva samples...
March 21, 2024: Environmental Research
https://read.qxmd.com/read/38521203/the-neurobiological-effects-of-senescence-on-dopaminergic-system-a-comprehensive-review
#34
REVIEW
Gabriel S Rocha, Marco Aurelio M Freire, Karina M Paiva, Rodrigo F Oliveira, Paulo Leonardo A G Morais, José Ronaldo Santos, José Rodolfo L P Cavalcanti
Over time, the body undergoes a natural, multifactorial, and ongoing process named senescence, which induces changes at the molecular, cellular, and micro-anatomical levels in many body systems. The brain, being a highly complex organ, is particularly affected by this process, potentially impairing its numerous functions. The brain relies on chemical messengers known as neurotransmitters to function properly, with dopamine being one of the most crucial. This catecholamine is responsible for a broad range of critical roles in the central nervous system, including movement, learning, cognition, motivation, emotion, reward, hormonal release, memory consolidation, visual performance, sexual drive, modulation of circadian rhythms, and brain development...
March 21, 2024: Journal of Chemical Neuroanatomy
https://read.qxmd.com/read/38520010/a-late-eating-midpoint-is-associated-with-increased-risk-of-diabetic-kidney-disease-a-cross-sectional-study-based-on-nhanes-2013-2020
#35
JOURNAL ARTICLE
Chun-Feng Lu, Xiao-Min Cang, Wang-Shu Liu, Li-Hua Wang, Hai-Yan Huang, Xue-Qin Wang, Li-Hua Zhao, Feng Xu
BACKGROUND: Modifying diet is crucial for diabetes and complication management. Numerous studies have shown that adjusting eating habits to align with the circadian rhythm may positively affect metabolic health. However, eating midpoint, eating duration, and their associations with diabetic kidney disease (DKD) are poorly understood. METHODS: The National Health and Nutrition Examination Survey (2013-2020) was examined for information on diabetes and dietary habits...
March 23, 2024: Nutrition Journal
https://read.qxmd.com/read/38519909/integrated-transcriptome-and-metabolome-analysis-reveals-anthocyanin-biosynthesis-mechanisms-in-pepper-capsicum-annuum-l-leaves-under-continuous-blue-light-irradiation
#36
JOURNAL ARTICLE
Yao Zhou, Weisheng Wu, Ying Sun, Yiyu Shen, Lianzhen Mao, Yunhua Dai, Bozhi Yang, Zhoubin Liu
BACKGROUND: Different metabolic compounds give pepper leaves and fruits their diverse colors. Anthocyanin accumulation is the main cause of the purple color of pepper leaves. The light environment is a critical factor affecting anthocyanin biosynthesis. It is essential that we understand how to use light to regulate anthocyanin biosynthesis in plants. RESULT: Pepper leaves were significantly blue-purple only in continuous blue light or white light (with a blue light component) irradiation treatments, and the anthocyanin content of pepper leaves increased significantly after continuous blue light irradiation...
March 23, 2024: BMC Plant Biology
https://read.qxmd.com/read/38518598/gut-microbiota-in-neurological-diseases-melatonin-plays-an-important-regulatory-role
#37
REVIEW
Somayeh Ahmadi, Mohammad Taghizadieh, Elham Mehdizadehfar, Alka Hasani, Javad Khalili Fard, Hadi Feizi, Hammed Hamishehkar, Masood Ansarin, Mina Yekani, Mohammad Yousef Memar
Melatonin is a highly conserved molecule produced in the human pineal gland as a hormone. It is known for its essential biological effects, such as antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut is one of the primary known sources of melatonin. The gut microbiota helps produce melatonin from tryptophan, and melatonin has been shown to have a beneficial effect on gut barrier function and microbial population. Dysbiosis of the intestinal microbiota is associated with bacterial imbalance and decreased beneficial microbial metabolites, including melatonin...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38517516/osrr26-a-type-b-response-regulator-modulates-salinity-tolerance-in-rice-via-phytohormone-mediated-ros-accumulation-in-roots-and-influencing-reproductive-development
#38
JOURNAL ARTICLE
Ramsong Chantre Nongpiur, Nishtha Rawat, Sneh Lata Singla-Pareek, Ashwani Pareek
OsRR26 is a cytokinin-responsive response regulator that promotes phytohormone-mediated ROS accumulation in rice roots, regulates seedling growth, spikelet fertility, awn development, represses NADPH oxidases, and negatively affects salinity tolerance. Plant two-component systems (TCS) play a pivotal role in phytohormone signaling, stress responses, and circadian rhythm. However, a significant knowledge gap exists regarding TCS in rice. In this study, we utilized a functional genomics approach to elucidate the role of OsRR26, a type-B response regulator in rice...
March 22, 2024: Planta
https://read.qxmd.com/read/38517469/remote-evaluation-of-sleep-and-circadian-rhythms-in-older-adults-with-mild-cognitive-impairment-and-dementia-protocol-for-a-feasibility-and-acceptability-mixed-methods-study
#39
JOURNAL ARTICLE
Victoria Grace Gabb, Jonathan Blackman, Hamish Duncan Morrison, Bijetri Biswas, Haoxuan Li, Nicholas Turner, Georgina M Russell, Rosemary Greenwood, Amy Jolly, William Trender, Adam Hampshire, Alan Whone, Elizabeth Coulthard
BACKGROUND: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. OBJECTIVE: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD. METHODS: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment...
March 22, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38517356/circadian-changes-in-aperiodic-activity-are-correlated-with-seizure-reduction-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-responsive-neurostimulation
#40
JOURNAL ARTICLE
Chantel M Charlebois, Daria Nesterovich Anderson, Elliot H Smith, Tyler S Davis, Blake J Newman, Angela Y Peters, Amir M Arain, Alan D Dorval, John D Rolston, Christopher R Butson
OBJECTIVES: Responsive neurostimulation (RNS) is an established therapy for drug-resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in seizure frequency, clinical outcomes are variable, and few patients become seizure-free. The aim of this retrospective study was to evaluate aperiodic electrophysiological activity, associated with excitation/inhibition balance, as a novel electrographic biomarker of seizure reduction to aid early prognostication of the clinical response to RNS...
March 22, 2024: Epilepsia
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