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Michelle Bedenbaugh, Rick McCosh, Justin Lopez, John Connors, Robert L Goodman, Stan Hileman
<br> Background: Neuronal intermediates that communicate estrogen and progesterone feedback to gonadotropin-releasing hormone (GnRH) neurons are essential for modulating reproductive cyclicity. Individually, kisspeptin and nitric oxide (NO) influence GnRH secretion. However, it is possible these two neuronal intermediates interact with one another to affect reproductive cyclicity. METHODS: We investigated the neuroanatomical relationship of one isoform of the enzyme that synthesizes NO, neuronal nitric oxide synthase (nNOS), to kisspeptin and GnRH in adult female rhesus monkeys and sheep using dual-label immunofluorescence...
June 21, 2018: Neuroendocrinology
Daniel J Tobiansky, Kathryn G Wallin-Miller, Stan B Floresco, Ruth I Wood, Kiran K Soma
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how endogenous and exogenous androgens alter behaviors, such as behavioral flexibility, decision making, and risk taking. First, we briefly review the neuroanatomy of the mesocorticolimbic system, which mediates executive function, with a focus on the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (mPFC), and orbitofrontal cortex (OFC)...
2018: Frontiers in Endocrinology
Felix R H Jonas, Kate E Royle, Rochelle Aw, Guy-Bart V Stan, Karen M Polizzi
Adaptation allows organisms to maintain a constant internal environment, which is optimised for growth. The unfolded protein response (UPR) is an example of a feedback loop that maintains endoplasmic reticulum (ER) homeostasis, and is characteristic of how adaptation is often mediated by transcriptional networks. The more recent discovery of asymmetric division in maintaining ER homeostasis, however, is an example of how alternative non-transcriptional pathways can exist, but are overlooked by gold standard transcriptomic or proteomic population-based assays...
March 2018: Synthetic and Systems Biotechnology
Kristian W Pajtler, Ji Wen, Martin Sill, Tong Lin, Wilda Orisme, Bo Tang, Jens-Martin Hübner, Vijay Ramaswamy, Sujuan Jia, James D Dalton, Kelly Haupfear, Hazel A Rogers, Chandanamali Punchihewa, Ryan Lee, John Easton, Gang Wu, Timothy A Ritzmann, Rebecca Chapman, Lukas Chavez, Fredrick A Boop, Paul Klimo, Noah D Sabin, Robert Ogg, Stephen C Mack, Brian D Freibaum, Hong Joo Kim, Hendrik Witt, David T W Jones, Baohan Vo, Amar Gajjar, Stan Pounds, Arzu Onar-Thomas, Martine F Roussel, Jinghui Zhang, J Paul Taylor, Thomas E Merchant, Richard Grundy, Ruth G Tatevossian, Michael D Taylor, Stefan M Pfister, Andrey Korshunov, Marcel Kool, David W Ellison
Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical parameters were similar. In contrast, PFA subtypes differed with respect to age at diagnosis, gender ratio, outcome, and frequencies of genetic alterations...
June 16, 2018: Acta Neuropathologica
Ana Banc, Cristina Stan, Alexandra-Stefania Berghe, Tudor Catalin Drugan, Ioan-Stefan Florian
OBJECTIVE: Optical coherence tomography (OCT) is a non-invasive high-resolution imaging technique which was suggested to be a powerful biomarker of neurodegeneration. The objective of our study is to assess the pattern of retinal OCT changes in patients with visual pathway tumors. METHODS: A prospective clinical study was conducted and patients with single cerebral tumors with potential of compression on the visual pathway were included. Patients with multiple and/or metastatic tumors were excluded...
June 14, 2018: World Neurosurgery
Karel E Y Claes, Salvatore D'Arpa, Stan J Monstrey
Chest surgery can greatly facilitate the experience of living in a gender role. For transfeminine chest surgery, most surgeons recommend a 12-month period of feminizing hormone therapy prior to breast augmentation. For those who already have some breast volume due to hormone treatment, lipofilling can be a good option. Transmasculine chest surgery includes mastectomy and creation of a male chest. Preoperative parameters to be evaluated include breast volume, degree of excess skin, nipple-areola complex size and position, and skin elasticity...
July 2018: Clinics in Plastic Surgery
Karel E Y Claes, Piet Pattyn, Salvatore D'Arpa, Cedric Robbens, Stan J Monstrey
The major steps in vaginoplasty are orchiectomy, penile amputation, creation of the neovaginal cavity with lining, and reconstruction of urethral meatus, labia, and clitoris. During pedicled intestinal transfer, an intestinal segment is transferred in a dissected cavity between the bladder and rectum. The bowel harvest is performed by a total laparoscopic technique. It is imperative to create the labia majora and minora, the clitoris, and a clitoral hood to achieve the physiologic and aesthetic equivalent of female external genitalia...
July 2018: Clinics in Plastic Surgery
Ulf Landmesser, Stan Hazen
No abstract text is available yet for this article.
June 14, 2018: European Heart Journal
Radek Martinek, Radana Kahankova, Janusz Jezewski, Rene Jaros, Jitka Mohylova, Marcel Fajkus, Jan Nedoma, Petr Janku, Homer Nazeran
Non-adaptive signal processing methods have been successfully applied to extract fetal electrocardiograms (fECGs) from maternal abdominal electrocardiograms (aECGs); and initial tests to evaluate the efficacy of these methods have been carried out by using synthetic data. Nevertheless, performance evaluation of such methods using real data is a much more challenging task and has neither been fully undertaken nor reported in the literature. Therefore, in this investigation, we aimed to compare the effectiveness of two popular non-adaptive methods (the ICA and PCA) to explore the non-invasive (NI) extraction (separation) of fECGs, also known as NI-fECGs from aECGs...
2018: Frontiers in Physiology
Michael J L Peers, Yasmine N Majchrzak, Eric Neilson, Clayton T Lamb, Anni Hämäläinen, Jessica A Haines, Laura Garland, Darcy Doran-Myers, Kate Broadley, Rudy Boonstra, Stan Boutin
In recent years, it has been argued that the effect of predator fear exacts a greater demographic toll on prey populations than the direct killing of prey. However, efforts to quantify the effects of fear have primarily relied on experiments that replace predators with predator cues. Interpretation of these experiments must consider two important caveats: 1) the magnitude of experimenter-induced predator cues may not be realistically comparable to those of the prey's natural sensory environment, and 2) given functional predators are removed from the treatments, the fear effect is measured in the absence of any consumptive effects, a situation which never occurs in nature...
June 13, 2018: Ecology
Stan Benjamens, Robert A Pol, Andor W J M Glaudemans, Ivanka Wieringa, Stefan P Berger, Stephan J L Bakker, Riemer H J A Slart
Background: Aortic calcification is associated with an increased risk for cardiovascular events in renal transplant recipients. This study focused on the association of abdominal aortic calcification (AAC) and cardiovascular events assessed using a dual-energy X-ray absorptiometry (DXA) scoring methodology for AAC. Methods: From 2008 to 2014, renal transplant recipients referred for a DXA procedure within 6 months after transplantation were included in a retrospective, single-centre study...
June 11, 2018: Nephrology, Dialysis, Transplantation
Joshua J Thomas, Anthony A Stans, Todd A Milbrandt, Vickie M Treder, Hilal Maradit Kremers, William J Shaughnessy, A Noelle Larson
BACKGROUND: With new data supporting the efficacy of bracing, the role of school screening for early detection of moderate scoliosis curves has been revisited. Because of a high rate of false-positive screening and cost concerns, a comprehensive county-wide school screening program was discontinued in 2004. We aim to determine the impact of a comprehensive school screening program on curve magnitude at presentation and initial scoliosis treatment for all local county patients presenting to a pediatric orthopedic clinic from all referral sources...
July 2018: Spine Deformity
Stan van Pelt, Elena Shumskaya, Pascal Fries
Visually induced gamma-band activity (GBA) has been implicated in several central cognitive functions, in particular perceptual binding, the feedforward routing of attended stimulus information and memory encoding. Several studies have documented that the strength and frequency of GBA are influenced by both subject-intrinsic factors like age, and subject-extrinsic factors such as stimulus contrast. Here, we investigated the relative contributions of previously tested factors, additional factors, and their interactions, in a cohort of 158 subjects recorded with magnetoencephalography (MEG)...
June 5, 2018: NeuroImage
Brent C James, David P Edwards, Alan F James, Richard L Bradshaw, Keith S White, Chris Wood, Stan Huff
Current commercially-available electronic medical record systems produce mainly text-based information focused on financial and regulatory performance. We combined an existing method for organizing complex computer systems-which we label activity-based design-with a proven approach for integrating clinical decision support into front-line care delivery-Care Process Models. The clinical decision support approach increased the structure of textual clinical documentation, to the point where established methods for converting text into computable data (natural language processing) worked efficiently...
December 15, 2017: EGEMS
Kalyani Abhimanyu Kedar, Sanjay Ravindra Chaudhari, Avanapu Srinivasa Rao
The data presented in this article are related to the scanning electron microscope and elemental studies in the four species of Bignoniaceae namely Tecoma gaudichaudi DC (Sample 1), Tecoma capensis (Thunb.) Lindl. (Sample 2), Tecoma stans (L.) Juss.Ex Kunth (Sample 3), Tabebuia rosea (Bertol.) (Sample 4). The SEM images were obtained for permanent record. The abaxial and adaxial surfaces of each species were carefully studied. In addition to this, the consistent occurrence of anomocytic stomata in all four species of this family shows that morphological and taxonomically all the species are very close and intimate...
April 2018: Data in Brief
Aijie Liu, Mark V de Ruiter, Stan J Maassen, Jeroen J L M Cornelissen
Viral protein cage-based nanoreactors can be generated by encapsulation of catalytic metal nanoparticles within the capsid structure. In this method, coat proteins of the cowpea chlorotic mottle virus (CCMV) are used to sequester gold nanoparticles (Au NPs) in buffered solutions at neutral pH to form CCMV-Au hybrid nanoparticles. This chapter describes detailed methods for the encapsulation of Au NPs into CCMV protein cages. Protocols for the reduction of nitroarenes by using CCMV-Au NPs as catalyst are described as an example for the catalytic activity of Au NPs in the protein cages...
2018: Methods in Molecular Biology
Isaac Asante, Hua Pei, Eugene Zhou, Siyu Liu, Darryl Chui, EunJeong Yoo, Stan G Louie
An analytical method using electrospray ionization and high- performance liquid chromatography/tandem mass spectrometry (LC/ESI-MS/MS) was developed to quantify the vitamin B metabolites found in the folate one-carbon metabolism, using 50 μL of human plasma. Analytes in plasma were extracted using protein precipitation after being stabilized in 1% ascorbic acid. The analytes were separated using a Kinetex 2.6 μm Pentafluorophenyl (2.1 × 30 mm) column utilizing a gradient mobile phase system of 0...
May 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xavier Mouy, Rodney Rountree, Francis Juanes, Stan E Dosso
Although many fish are soniferous, few of their sounds have been identified, making passive acoustic monitoring (PAM) ineffective. To start addressing this issue, a portable 6-hydrophone array combined with a video camera was assembled to catalog fish sounds in the wild. Sounds are detected automatically in the acoustic recordings and localized in three dimensions using time-difference of arrivals and linearized inversion. Localizations are then combined with the video to identify the species producing the sounds...
May 2018: Journal of the Acoustical Society of America
Julien Bonnel, Ying-Tsong Lin, Dimitrios Eleftherakis, John A Goff, Stan Dosso, Ross Chapman, James H Miller, Gopu R Potty
This paper presents single receiver geoacoustic inversion of a combustive sound source signal, recorded during the 2017 Seabed Characterization Experiment on the New England Mud Patch, in an area where water depth is around 70 m. There are two important features in this study. First, it is shown that high-order modes can be resolved and estimated using warping (up to mode number 18 over the frequency band 20-440 Hz). However, it is not possible to determine mode numbers from the data, so that classical inversion methods that require mode identification cannot be applied...
May 2018: Journal of the Acoustical Society of America
Renata Pacholczak, Stanisława Bazan-Socha, Teresa Iwaniec, Lech Zaręba, Stan Kielczewski, Jerzy A Walocha, Jacek Musiał, Jerzy Dropiński
BACKGROUND: Granulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients with long-standing disease, the common cause of death is atherosclerosis even in the absence of typical risk factors. OBJECTIVE: To evaluate endothelial dysfunction in GPA patients. METHODS: 44 patients (21 men and 23 women) diagnosed with GPA and 53 controls matched for age, sex, BMI and typical risk factors for cardiovascular diseases (22 men and 31 women) were enrolled in the study...
May 30, 2018: Rheumatology International
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