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https://www.readbyqxmd.com/read/29687944/association-of-copy-number-variation-across-the-genome-with-neuropsychiatric-traits-in-the-general-population
#1
Anna L Guyatt, Evie Stergiakouli, Joanna Martin, James Walters, Michael O'Donovan, Michael Owen, Anita Thapar, George Kirov, Santiago Rodriguez, Dheeraj Rai, Stan Zammit, Tom R Gaunt
Copy number variants (CNVs) are associated with psychiatric conditions in clinical populations. The relationship between rare CNV burden and neuropsychiatric traits in young, general populations is underexplored. A total of 6,807 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were studied. CNVs were inferred from single nucleotide polymorphism-array data using PennCNV. After excluding children with known candidate CNVs for schizophrenia (SCZ), rare (<1%) CNV burden (total number of genes affected by CNVs, total length of CNVs, and largest CNV carried) was analyzed in relation to: psychotic experiences (PEs) and anxiety/depression in adolescence; autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), ASD and ADHD traits, and cognitive measures during childhood...
April 24, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29687748/magnetic-resonance-conditional-paramagnetic-choke-for-suppression-of-imaging-artifacts-during-magnetic-resonance-imaging
#2
Kevin J Wu, T Stan Gregory, Brian L Boland, Wujun Zhao, Rui Cheng, Leidong Mao, Zion Tsz Ho Tse
Higher risk patient populations require continuous physiological monitoring and, in some cases, connected life-support systems, during magnetic resonance imaging examinations. While recently there has been a shift toward wireless technology, some of the magnetic resonance imaging devices are still connected to the outside using cabling that could interfere with the magnetic resonance imaging's radio frequency during scanning, resulting in excessive heating. We developed a passive method for radio frequency suppression on cabling that may assist in making some of these devices magnetic resonance imaging compatible...
April 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29687011/incidence-of-elbow-ulnar-collateral-ligament-surgery-in-collegiate-baseball-players
#3
Marcus A Rothermich, Stan A Conte, Kyle T Aune, Glenn S Fleisig, E Lyle Cain, Jeffrey R Dugas
Background: Recent reports have highlighted the progressive increase in the incidence of ulnar collateral ligament (UCL) injuries to the elbow in baseball players of all levels. However, knowledge of the incidence and other epidemiological factors regarding UCL injuries, specifically in college baseball players, is currently lacking. Purpose: To evaluate, over a period of 1 year, the incidence of UCL injuries requiring surgery in National Collegiate Athletic Association (NCAA) Division I baseball programs...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29686308/unique-treatment-potential-of-cannabidiol-for-the-prevention-of-relapse-to-drug-use-preclinical-proof-of-principle
#4
Gustavo Gonzalez-Cuevas, Remi Martin-Fardon, Tony M Kerr, David G Stouffer, Loren H Parsons, Dana C Hammell, Stan L Banks, Audra L Stinchcomb, Friedbert Weiss
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, has received attention for therapeutic potential in treating neurologic and psychiatric disorders. Recently, CBD has also been explored for potential in treating drug addiction. Substance use disorders are chronically relapsing conditions and relapse risk persists for multiple reasons including craving induced by drug contexts, susceptibility to stress, elevated anxiety, and impaired impulse control. Here, we evaluated the "anti-relapse" potential of a transdermal CBD preparation in animal models of drug seeking, anxiety and impulsivity...
March 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29680377/computational-re-design-of-synthetic-genetic-oscillators-for-independent-amplitude-and-frequency-modulation
#5
Marios Tomazou, Mauricio Barahona, Karen M Polizzi, Guy-Bart Stan
To perform well in biotechnology applications, synthetic genetic oscillators must be engineered to allow independent modulation of amplitude and period. This need is currently unmet. Here, we demonstrate computationally how two classic genetic oscillators, the dual-feedback oscillator and the repressilator, can be re-designed to provide independent control of amplitude and period and improve tunability-that is, a broad dynamic range of periods and amplitudes accessible through the input "dials." Our approach decouples frequency and amplitude modulation by incorporating an orthogonal "sink module" where the key molecular species are channeled for enzymatic degradation...
April 10, 2018: Cell Systems
https://www.readbyqxmd.com/read/29680328/epidemiology-of-ulnar-collateral-ligament-reconstruction-in-major-and-minor-league-baseball-pitchers-comprehensive-report-of-1429-cases
#6
Christopher L Camp, Stan Conte, John D'Angelo, Stephen A Fealy
BACKGROUND: The primary purpose of this work is to provide an epidemiologic report on every known ulnar collateral ligament (UCL) reconstruction performed in professional baseball with a special focus on outcomes and survivorship. METHODS: Three resources, including the Major League Baseball (MLB) injury tracking system, were combined and cross-referenced to identify all known professional baseball pitchers who had ever undergone UCL reconstruction from 1974 to 2016...
May 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29679115/analyzing-chromatographic-data-using-multilevel-modeling
#7
Paweł Wiczling
It is relatively easy to collect chromatographic measurements for a large number of analytes, especially with gradient chromatographic methods coupled with mass spectrometry detection. Such data often have a hierarchical or clustered structure. For example, analytes with similar hydrophobicity and dissociation constant tend to be more alike in their retention than a randomly chosen set of analytes. Multilevel models recognize the existence of such data structures by assigning a model for each parameter, with its parameters also estimated from data...
April 21, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29675448/intestinal-farnesoid-x-receptor-activation-by-pharmacologic-inhibition-of-the-organic-solute-transporter-%C3%AE-%C3%AE
#8
Sandra M W van de Wiel, D Rudi de Waart, Ronald P J Oude Elferink, Stan F J van de Graaf
Background & Aims: The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects as intestine-specific agonists of the major nuclear receptor for bile acids, the farnesoid X receptor (FXR). However, no OSTα-OSTβ inhibitors have yet been identified. Methods: Here, we developed a screen to identify specific inhibitors of OSTα-OSTβ using a genetically encoded Förster Resonance Energy Transfer (FRET)-bile acid sensor that enables rapid visualization of bile acid efflux in living cells...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29674158/economic-analysis-of-threatened-species-conservation-the-case-of-woodland-caribou-and-oilsands-development-in-alberta-canada
#9
Grant Hauer, W L Vic Adamowicz, Stan Boutin
Tradeoffs between cost and recovery targets for boreal caribou herds, threatened species in Alberta, Canada, are examined using a dynamic cost minimization model. Unlike most approaches used for minimizing costs of achieving threatened species targets, we incorporate opportunity costs of surface (forests) and subsurface resources (energy) as well as direct costs of conservation (habitat restoration and direct predator control), into a forward looking model of species protection. Opportunity costs of conservation over time are minimized with an explicit target date for meeting species recovery targets; defined as the number of self-sustaining caribou herds, which requires that both habitat and population targets are met by a set date...
April 16, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29671920/who-said-dialogue-conversations-are-easy-the-communication-between-communication-vulnerable-people-and-health-care-professionals-a-qualitative-study
#10
Steffy E A Stans, Ruth J P Dalemans, Uta R Roentgen, Hester W H Smeets, Anna J H M Beurskens
OBJECTIVE: To gain insight into how communication vulnerable people and health-care professionals experience the communication in dialogue conversations, and how they adjust their conversation using augmentative and alternative communication (AAC) or other communication strategies. METHODS: Communication vulnerable clients and health-care professionals in a long-term care institution were observed during a dialogue conversation (n = 11) and subsequently interviewed (n = 22) about their experiences with the conversation...
April 19, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29667460/clinical-utility-of-remote-platelet-function-measurement-using-p-selectin-assessment-of-aspirin-clopidogrel-and-prasugrel-and-bleeding-disorders
#11
Philip M Bath, Jane May, Stan Heptinstall
Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing platelet function tests may not be ideal in that they can be expensive, are often time consuming, and measurements must be made near to the patient and within a few hours of blood collection. Platelet activation leads to translocation of P-selectin from alpha-granules to the cell surface...
April 18, 2018: Platelets
https://www.readbyqxmd.com/read/29664512/short-stature-and-hypothyroidism-in-a-child-with-nail-patella-syndrome-a-case-report
#12
C Goecke, C Mellado, C García, H García
BACKGROUND: Nail-Patella syndrome (NPS) (OMIM: 161200) or hereditary onycho-osteodysplasia is an autosomal dominant disorder characterized by skeletal anomalies, nail dysplasia, renal and ocular abnor malities. The diagnosis is based on clinical and radiological findings and confirmed by the identification of a heterozygous pathogenic variant in the LMX1B gene. Management of these patients involves conti nuous follow-up and treatment ofthe orthopedical, ocular and renal problems that mayoccur...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663378/tyrosine-kinase-receptor-c-ros-oncogene-1-inhibition-alleviates-aberrant-bone-formation-of-twist-1-haploinsufficient-calvarial-cells-from-saethre-chotzen-syndrome-patients
#13
Esther Camp, Peter J Anderson, Andrew C W Zannettino, Carlotta A Glackin, Stan Gronthos
Saethre-Chotzen syndrome (SCS), associated with TWIST-1 mutations, is characterized by premature fusion of cranial sutures. TWIST-1 haploinsufficiency, leads to alterations in suture mesenchyme cellular gene expression patterns, resulting in aberrant osteogenesis and craniosynostosis. We analyzed the expression of the TWIST-1 target, Tyrosine kinase receptor c-ros-oncogene 1 (C-ROS-1) in TWIST-1 haploinsufficient calvarial cells derived from SCS patients and calvaria of Twist-1del/+ mutant mice and found it to be highly expressed when compared to TWIST-1 wild-type controls...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663006/silicon-compatible-sn-based-resistive-switching-memory
#14
Sushant Sonde, Bhaswar Chakrabarti, Yuzi Liu, Kiran Sasikumar, Jianqiang Lin, Liliana Stan, Ralu Divan, Leonidas E Ocola, Daniel Rosenmann, Pabitra Choudhury, Kai Ni, Subramanian K R S Sankaranarayanan, Suman Datta, Supratik Guha
Large banks of cheap, fast, non-volatile, energy efficient, scalable solid-state memories are an increasingly essential component for today's data intensive computing. Conductive-bridge random access memory (CBRAM) - which involves voltage driven formation and dissolution of Cu or Ag filaments in a Cu (or Ag) anode/dielectric (HfO2 or Al2O3)/inert cathode device - possesses the necessary attributes to fit the requirements. Cu and Ag are, however, fast diffusers and known contaminants in silicon microelectronics...
April 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29659625/st-waveform-analysis-for-monitoring-hypoxic-distress-in-fetal-sheep-after-prolonged-umbilical-cord-occlusion
#15
Peter Andriessen, Alex Zwanenburg, Judith O E H van Laar, Rik Vullings, Ben J M Hermans, Hendrik J Niemarkt, Reint K Jellema, Daan R M G Ophelders, Tim G A M Wolfs, Boris W Kramer, Tammo Delhaas
INTRODUCTION: The inconclusive clinical results for ST-waveform analysis (STAN) in detecting fetal hypoxemia may be caused by the signal processing of the STAN-device itself. We assessed the performance of a clinical STAN device in signal processing and in detecting hypoxemia in a fetal sheep model exposed to prolonged umbilical cord occlusion (UCO). METHODS: Eight fetal lambs were exposed to 25 minutes of UCO. ECG recordings were analyzed during a baseline period and during UCO...
2018: PloS One
https://www.readbyqxmd.com/read/29658932/in-situ-high-pressure-hydrogen-tribological-testing-of-common-polymer-materials-used-in-the-hydrogen-delivery-infrastructure
#16
Edward R Duranty, Timothy J Roosendaal, Stan G Pitman, Joseph C Tucker, Stanley L Owsley, Jonathan D Suter, Kyle James Alvine
High pressure hydrogen gas is known to adversely affect metallic components of compressors, valves, hoses, and actuators. However, relatively little is known about the effects of high pressure hydrogen on the polymer sealing and barrier materials also found within these components. More study is required in order to determine the compatibility of common polymer materials found in the components of the hydrogen fuel delivery infrastructure with high pressure hydrogen. As a result, it is important to consider the changes in physical properties such as friction and wear in situ while the polymer is exposed to high pressure hydrogen...
March 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29656232/gallium-incorporation-into-phosphate-based-glasses-bulk-and-thin-film-properties
#17
Bryan W Stuart, Colin A Grant, George E Stan, Adrian C Popa, Jeremy J Titman, David M Grant
The osteogenic ions Ca2+ , P5+ , Mg2+ , and antimicrobial ion Ga3+ were homogenously dispersed into a 1.45 µm thick phosphate glass coating by plasma assisted sputtering onto commercially pure grade titanium. The objective was to deliver therapeutic ions in orthopaedic/dental implants such as cementeless endoprostheses or dental screws. The hardness 4.7 GPa and elastic modulus 69.7 GPa, of the coating were comparable to plasma sprayed hydroxyapatite/dental enamel, whilst superseding femoral cortical bone...
March 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29652091/hunger-makes-apex-predators-do-risky-things
#18
Stan Boutin
In Focus: Blecha, K. A., Boone, R. B., & Alldredge, M. W. (2018). Hunger mediates apex predator's risk avoidance response in wildland-urban interface. Journal of Animal Ecology, 87, 609-622. https://doi.org/10.1111/1365-2656.12801 Puma (Puma concolor), an apex predator, can live at the edge of cities where pockets of low-density human dwellings form residential patches in the wildland-urban interface. Blecha, Boone, and Alldredge () tracked puma via global positioning system (GPS) telemetry collars to determine when and where they hunted and made kills...
May 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29651784/are-the-effects-of-cognitive-behavior-therapy-for-severe-fatigue-in-cancer-survivors-sustained-up-to-14-years-after-therapy
#19
Lidewij D Van Gessel, Harriët J G Abrahams, Hetty Prinsen, Gijs Bleijenberg, Marianne Heins, Jos Twisk, Hanneke W M Van Laarhoven, Stans C A H H V M Verhagen, Marieke F M Gielissen, Hans Knoop
PURPOSE: Cognitive behavior therapy (CBT) reduces cancer-related fatigue (CRF) in cancer survivors in the short term. We examined fatigue levels up to 14 years after CBT. METHODS: Eligible participants of two randomized controlled trials who had completed CBT for CRF and a post-treatment assessment were contacted (n = 81). Fatigue was assessed with the subscale "fatigue severity" of the Checklist Individual Strength (CIS-fatigue). The course of fatigue over time was examined with linear mixed model analyses...
April 12, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29649449/specifying-what-we-study-and-implement-in-rehabilitation-comments-on-the-reporting-of-clinical-research
#20
John Whyte, Marcel P Dijkers, Jarrad H Van Stan, Tessa Hart
Several guidelines have been published with the goal of increasing the usefulness of reports of clinical research. Although such guidelines may clarify key features of study design, the way in which rehabilitation treatments, themselves, are described continues to be problematic and to limit the ability to replicate research, synthesize evidence across studies, or apply these treatments in practice. Lohse, et al report little improvement in the description of rehabilitation treatments in recent years, with particular limitations in the description of comparison or standard-of-care treatments...
April 9, 2018: Archives of Physical Medicine and Rehabilitation
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