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https://www.readbyqxmd.com/read/28429639/review-of-doing-bayesian-data-analysis-a-tutorial-with-r-jags-and-stan-second-edition
#1
Charles E Gaudet
No abstract text is available yet for this article.
April 21, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28424174/the-clinical-value-of-regular-thyroid-function-tests-during-amiodarone-treatment
#2
Stan Benjamens, Robin P F Dullaart, Wim J Sluiter, Michiel Rienstra, Isabelle C van Gelder, Thera P Links
OBJECTIVE: Amiodarone is used for the maintenance of sinus rhythm in patients with arrhythmias, but thyroid dysfunction (amiodarone-induced thyrotoxicosis(AIT) or -hypothyroidism(AIH)) is a common adverse effect. Since the onset of AIT and AIH may be unpredictable, the value of long-term regular monitoring of amiodarone treated patients for thyroid dysfunction is still uncertain. DESIGN: We retrospectively documented the frequency at which overt thyroid dysfunction was preceded by subclinical thyroid dysfunction...
April 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28419443/loss-of-natural-killer-t-nkt-cells-promotes-pancreatic-cancer-in-lsl-kras-g12d-mice
#3
Naveena B Janakiram, Altaf Mohammed, Taylor Bryant, Rebekah Ritchie, Nicole Stratton, Lydgia Jackson, Stan Lightfoot, Doris M Benbrook, Adam Asch, Mark L Lang, Chinthalapally V Rao
Role of unique T cell population, Natural Killer T (NKT) cells which have similar functions like NK cells in PC is not yet evaluated. In order to address the regulatory roles of NKT cells on tumor progression through tumor-associated macrophages (TAM) and their production of microsomal prostaglandin E synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX) in (Kras)-driven pancreatic tumor (KPT) progression, we crossed CD1d(-/-) mice deficient in both iNKT and vNKT cells with the Kras(G12D) mice. Loss of NKT cells significantly increased pancreatic intraepithelial neoplasia lesions [PanINs] and also increased 5-LOX and mPGES-1 expressions in M2 type macrophages and cancer stem like cells in pancreatic tumors...
April 18, 2017: Immunology
https://www.readbyqxmd.com/read/28416388/human-grp78-affinity-towards-its-signaling-partners-ire1%C3%AE-and-perk-is-differently-modulated-by-an-unfolded-protein-client
#4
Razvan C Stan, Raissa L Silva, Maristela M de Camargo
Protein-folding stress is characteristic of specialized secretory cells and plays a dominant role in a multitude of diseases. The unfolded protein response (UPR) thus triggered is a proteostatic signaling network that adapts the protein-folding capacity of the endoplasmic reticulum to the cellular demands. We have measured the binding affinities between human GRP78, an essential chaperone located in ER, and two transmembrane UPR sensors (human PERK and Ire1α), with or without the addition of an unfolded protein client...
April 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28414406/residency-training-in-family-medicine-a-history-of-innovation-and-program-support
#5
Peter J Carek, Tanya Anim, Colleen Conry, Sam Cullison, Stan Kozakowski, Dan Ostergaard, Stacy Potts, Perry A Pugno
Residency programs have been integral to the development, expansion and progression of family medicine as a discipline. Three reports formed the foundation for graduate medical education in family medicine: Meeting the Challenge of Family Practice, The Graduate Education of Physicians, and Health is a Community Affair. In addition, the original core concepts of comprehensiveness, coordination, continuity, and patient centeredness continue to serve as the foundation for residency training in family medicine...
April 2017: Family Medicine
https://www.readbyqxmd.com/read/28409668/broca-s-area-communication-and-collaboration-in-spine-neuromonitoring-time-to-expect-more-a-lot-more-from-the-neurophysiologists
#6
Stan Skinner, Francesco Sala
No abstract text is available yet for this article.
April 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28407892/molecular-characterization-and-bio-functional-property-determination-using-sds-page-and-rp-hplc-of-protein-fractions-from-two-nigella-species
#7
Muhammad H Alu'datt, Taha Rababah, Mohammad N Alhamad, Moh'd Alodat, Majdi A Al-Mahasneh, Sana Gammoh, Khalil Ereifej, Ali Almajwal, Stan Kubow
This study aimed to investigate the molecular and bio-functional properties of protein fractions from Nigella damascena and Nigella arvensis, including the albumin, globulin, glutein-1, glutein-2 and prolamin fractions. Protein subunits were not observed in globulin and prolamin fractions. No peaks appeared in RP-HPLC chromatograms of globulin for either species. Two predominant peaks were observed in the RP-HPLC profiles of all protein fractions. Proteins separated by RP-HPLC have potential inhibitory and antioxidant activities in all fractions...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28405966/pointwise-influence-matrices-for-functional-response-regression
#8
Philip T Reiss, Lei Huang, Pei-Shien Wu, Huaihou Chen, Stan Colcombe
We extend the notion of an influence or hat matrix to regression with functional responses and scalar predictors. For responses depending linearly on a set of predictors, our definition is shown to reduce to the conventional influence matrix for linear models. The pointwise degrees of freedom, the trace of the pointwise influence matrix, are shown to have an adaptivity property that motivates a two-step bivariate smoother for modeling nonlinear dependence on a single predictor. This procedure adapts to varying complexity of the nonlinear model at different locations along the function, and thereby achieves better performance than competing tensor product smoothers in an analysis of the development of white matter microstructure in the brain...
April 12, 2017: Biometrics
https://www.readbyqxmd.com/read/28403965/understanding-fetal-physiology-and-second-line-monitoring-during-labor
#9
REVIEW
C Garabedian, J De Jonckheere, L Butruille, P Deruelle, L Storme, V Houfflin-Debarge
Cardiotocography (CTG) is a technique used to monitor intrapartum fetal condition and is one of the most common obstetric procedures. Second line methods of fetal monitoring have been developed in an attempt to reduce unnecessary interventions due to continuous cardiotocography and to better identify fetuses at risk of intrapartum asphyxia. The acid-base balance of the fetus is evaluated by fetal blood scalp samples, the modification of the myocardial oxygenation by the fetal ECG ST-segment analysis (STAN) and the autonomic nervous system by the power spectral analysis of the fetal heart variability...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28395847/progress-and-inequities-in-maternal-mortality-in-afghanistan-ramos-ii-a-retrospective-observational-study
#10
Linda Bartlett, Amnesty LeFevre, Linnea Zimmerman, Sayed Ataullah Saeedzai, Sabera Torkamani, Weeda Zabih, Hannah Tappis, Stan Becker, Peter Winch, Marge Koblinsky, Ahmed Javed Rahmanzai
BACKGROUND: The risk of maternal death in Afghanistan is among the highest in the world; however, the risks within the country are poorly understood. Subnational maternal mortality estimates are needed along with a broader understanding of determinants to guide future maternal health programmes. Here we aimed to study maternal mortality risk and causes, care-seeking patterns, and costs within the country. METHODS: We did a household survey (RAMOS-II) in the urban area of Kabul city and the rural area of Ragh, Badakshan...
May 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28385959/crispr-cas-adapting-to-change
#11
REVIEW
Simon A Jackson, Rebecca E McKenzie, Robert D Fagerlund, Sebastian N Kieper, Peter C Fineran, Stan J J Brouns
Bacteria and archaea are engaged in a constant arms race to defend against the ever-present threats of viruses and invasion by mobile genetic elements. The most flexible weapons in the prokaryotic defense arsenal are the CRISPR-Cas adaptive immune systems. These systems are capable of selective identification and neutralization of foreign DNA and/or RNA. CRISPR-Cas systems rely on stored genetic memories to facilitate target recognition. Thus, to keep pace with a changing pool of hostile invaders, the CRISPR memory banks must be regularly updated with new information through a process termed CRISPR adaptation...
April 7, 2017: Science
https://www.readbyqxmd.com/read/28382885/intracellular-delivery-of-biologic-therapeutics-by-bacterial-secretion-systems
#12
Barnabas James Walker, Guy-Bart V Stan, Karen Marie Polizzi
Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potential solution: bacterial nanomachines that have evolved over millions of years to efficiently deliver proteins and nucleic acids across cell membranes and between cells. In this review, we provide a brief overview of the different bacterial systems capable of direct delivery into the eukaryotic cytoplasm and the medical applications for which they are being investigated, along with a perspective on the future directions of this exciting field...
April 6, 2017: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/28372102/bowhead-whale-localization-using-time-difference-of-arrival-data-from-asynchronous-recorders
#13
Graham A Warner, Stan E Dosso, David E Hannay
This paper estimates bowhead whale locations and uncertainties using nonlinear Bayesian inversion of the time-difference-of-arrival (TDOA) of low-frequency whale calls recorded on onmi-directional asynchronous recorders in the shallow waters of the northeastern Chukchi Sea, Alaska. A Y-shaped cluster of seven autonomous ocean-bottom hydrophones, separated by 0.5-9.2 km, was deployed for several months over which time their clocks drifted out of synchronization. Hundreds of recorded whale calls are manually associated between recorders...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28371859/classification-criteria-for-diffuse-idiopathic-skeletal-hyperostosis-a-lack-of-consensus
#14
Jonneke S Kuperus, Erin E A de Gendt, F Cumhur Oner, Pim A de Jong, Stan C F M Buckens, Alie E van der Merwe, George J R Maat, Elizabeth A Regan, Donald L Resnick, Reuven Mader, Jorrit-Jan Verlaan
Objectives.: DISH is a condition characterized by flowing ossifications of the spine with or without ossifications of entheses elsewhere in the body. Studies on the prevalence and pathogenesis of DISH use a variety of partly overlapping combinations of classification criteria, making meaningful comparisons across the literature difficult. The aim of this study was to systematically summarize the available criteria to support the development of a more uniform set of diagnostic/classification criteria...
March 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28363263/child-and-youth-mental-health
#15
Stan Kutcher
No abstract text is available yet for this article.
April 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28363260/suicide-prevention
#16
Stan Kutcher, Yifeng Wei, Pegah Behzadi
No abstract text is available yet for this article.
April 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28355928/measurement-properties-of-mental-health-literacy-tools-measuring-help-seeking-a-systematic-review
#17
Yifeng Wei, Patrick J McGrath, Jill Hayden, Stan Kutcher
BACKGROUND: Mental health literacy is important to improve help-seeking behaviors. However, the quality of mental health help-seeking tools remains unknown. AIMS: We conducted a systematic review to appraise the quality of such tools. METHODS: We searched databases for English publications addressing psychometrics of help-seeking tools. We included help-seeking tools addressing mental health in general and tools on four mental disorders: anxiety, depression, attention deficit hyperactivity disorder (ADHD) and schizophrenia...
March 30, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28335630/the-design-prototyping-and-formative-evaluation-of-an-assistive-robotic-table-art-for-stroke-patients
#18
Anthony L Threatt, Jessica Merino, Johnell O Brooks, Stan Healy, Constance Truesdail, Joseph Manganelli, Ian Walker, Keith Evan Green
OBJECTIVE: This article presents the results of an exploratory study in which 14 healthcare subject matter experts (H-SMEs) in addition to four research and design subject matter experts (RD-SMEs) at a regional rehabilitation hospital engaged in a series of complementary, participatory activities in order to design an assistive robotic table (ART). BACKGROUND: As designers, human factor experts, and healthcare professionals continue to work to integrate assistive human-robot technologies in healthcare, it is imperative to understand how the technology affects patient care from clinicians' perspectives...
April 2017: HERD
https://www.readbyqxmd.com/read/28335342/innovative-self-cleaning-and-biocompatible-polyester-textiles-nano-decorated-with-fe-n-doped-titanium-dioxide
#19
Ionela Cristina Nica, Miruna Silvia Stan, Anca Dinischiotu, Marcela Popa, Mariana Carmen Chifiriuc, Veronica Lazar, Gratiela G Pircalabioru, Eugenia Bezirtzoglou, Ovidiu G Iordache, Elena Varzaru, Iuliana Dumitrescu, Marcel Feder, Florin Vasiliu, Ionel Mercioniu, Lucian Diamandescu
The development of innovative technologies to modify natural textiles holds an important impact for medical applications, including the prevention of contamination with microorganisms, particularly in the hospital environment. In our study, Fe and N co-doped TiO₂ nanoparticles have been obtained via the hydrothermal route, at moderate temperature, followed by short thermal annealing at 400 °C. These particles were used to impregnate polyester (PES) materials which have been evaluated for their morphology, photocatalytic performance, antimicrobial activity against bacterial reference strains, and in vitro biocompatibility on human skin fibroblasts...
November 15, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28329366/ambulatory-voice-biofeedback-relative-frequency-and-summary-feedback-effects-on-performance-and-retention-of-reduced-vocal-intensity-in-the-daily-lives-of-participants-with-normal-voices
#20
Jarrad H Van Stan, Daryush D Mehta, Dagmar Sternad, Robert Petit, Robert E Hillman
Purpose: Ambulatory voice biofeedback has the potential to significantly improve voice therapy effectiveness by targeting carryover of desired behaviors outside the therapy session (i.e., retention). This study applies motor learning concepts (reduced frequency and delayed, summary feedback) that demonstrate increased retention to ambulatory voice monitoring for training nurses to talk softer during work hours. Method: Forty-eight nurses with normal voices wore the Voice Health Monitor (Mehta, Zañartu, Feng, Cheyne, & Hillman, 2012) for 6 days: 3 baseline days, 1 biofeedback day, 1 short-term retention day, and 1 long-term retention day...
March 21, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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