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Carbapenemase

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https://www.readbyqxmd.com/read/30006537/multidrug-resistant-citrobacter-freundii-st139-co-producing-ndm-1-and-cmy-152-from-china
#1
Lang Yang, Peihan Li, Beibei Liang, Xiaofeng Hu, Jinhui Li, Jing Xie, Chaojie Yang, Rongzhang Hao, Ligui Wang, Leili Jia, Peng Li, Shaofu Qiu, Hongbin Song
The emergence of carbapenemase-producing Citrobacter freundii poses a significant threat to public health worldwide. Here, we reported a C. freundii strain CWH001 which was resistant to all tested antimicrobials except tetracycline. Whole genome sequencing and analysis were performed. The strain, which belonged to a new sequence type ST139, showed close relationship with other foreign C. freundii strains through phylogenetic analysis. A novel variant of the intrinsic blaCMY gene located on the chromosome was identified and designated as blaCMY-152 ...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30006247/in-vitro-synergy-and-postantibiotic-effect-of-colistin-combinations-with-meropenem-and-vancomycin-against-enterobacteriaceae-with-multiple-carbapenem-resistance-mechanisms
#2
Branka Bedenić, Haris Car, Domagoj Slačanac, Mario Sviben, Marko Čačić, Amarela Lukić-Grlić, Ana Benčić, Dorotea Šijak, Marko Tripković, Nataša Beader
AIM: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study. METHODS: The antibiotic susceptibility was tested by broth microdilution method. Synergy was tested by chequerboard, time-kill and 2-well method...
July 10, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30004829/%C3%AE-lactam-and-fluoroquinolone-resistant-enterobacteriaceae-recovered-from-the-environment-of-human-and-veterinary-tertiary-care-hospitals
#3
Dimitria A Mathys, Dixie F Mollenkopf, Joany C Van Balen, Thomas E Wittum
The dissemination of Enterobacteriaceae expressing resistance to clinically important antibiotics such as extended-spectrum cephalosporins (ESC), carbapenems, and fluoroquinolones is of critical concern to both human and veterinary medicine. In healthcare facilities, the movement of patients, personnel, and equipment provides an opportunity for Enterobacteriaceae carrying antibiotic resistance genes to disseminate in the hospital environment where they pose a threat to patients, staff, and hospital visitors...
July 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/30004330/phenotypic-and-genotypic-correlation-of-carbapenememase-producing-enterobacteriaceae-and-problems-experienced-in-routine-screening
#4
A Singh-Moodley, O Perovic
BACKGROUND: The emergence and transmission of carbapenem-resistant Enterobacteriaceae (CRE) is a concern in both the clinical and public health arenas. Reliable and accurate detection of these organisms is required for patient management and infection prevention and control purposes. In the routine laboratory, phenotypic methods are utilised for identification of CRE. OBJECTIVES: To investigate the phenotypic profiles of suspected carbapenemase-producing Enterobacteriaceae (CPE) isolates generated by the automated MicroScan Walkaway system making use of the Clinical and Laboratory Standards Institute (CLSI) guidelines, and correlate these with carbapenemase production by molecular methods...
May 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/30004058/bacteriological-profile-of-ventilator-associated-pneumonia-in-a-tertiary-care-hospital
#5
Somi Patro, Gitanjali Sarangi, Padma Das, Ashoka Mahapatra, Dharitri Mohapatra, Bimoch Projna Paty, Nirupama Chayani
Background: Ventilator-associated pneumonia (VAP) is the most frequent intensive care unit (ICU)-acquired infection. The etiology of VAP and their antimicrobial susceptibility pattern varies with different patient populations and types of ICUs. Materials and Methods: An observational cross-sectional study was performed over a period of 2 years in a tertiary care hospital to determine the various etiological agents causing VAP and to detect the presence of multidrug-resistant (MDR) pathogens in these VAP patients...
July 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/30003866/antimicrobial-resistance-in-escherichia-coli
#6
Laurent Poirel, Jean-Yves Madec, Agnese Lupo, Anne-Kathrin Schink, Nicolas Kieffer, Patrice Nordmann, Stefan Schwarz
Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic mechanisms in E. coli correspond to the acquisition of genes coding for extended-spectrum β-lactamases (conferring resistance to broad-spectrum cephalosporins), carbapenemases (conferring resistance to carbapenems), 16S rRNA methylases (conferring pan-resistance to aminoglycosides), plasmid-mediated quinolone resistance (PMQR) genes (conferring resistance to [fluoro]quinolones), and mcr genes (conferring resistance to polymyxins)...
July 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/30003527/emergence-of-co-existence-of-bla-ndm-with-rmtc-and-qnrb-genes-in-clinical-carbapenem-resistant-klebsiella-pneumoniae-isolates-in-burning-center-from-southeast-of-iran
#7
Somayeh Kiaei, Mohammad Moradi, Hossein Hosseini Nave, Zahra Hashemizadeh, Majid Taati-Moghadam, Davood Kalantar-Neyestanaki
Dissemination of carbapenemase-producing Klebsiella pneumoniae along with 16S rRNA methyltransferase (16S-RMTase) has been caused as a great concern for healthcare settings. The aim of this study was to investigate the prevalence of resistance genes among K. pneumoniae isolates. During October 2015 to February 2016, 30 non-duplicative K. pneumoniae strains were isolated from clinical specimens in a burn center in Kerman, Iran. Antibiotic susceptibility tests of isolates, carbapenemase, extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamase-producing isolates were determined by phenotypic methods...
July 12, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29997749/first-detection-of-new-delhi-metallo-%C3%AE-lactamases-variants-ndm-1-ndm-2-among-pseudomonas-aeruginosa-isolated-from-iraqi-hospitals
#8
Sarah Jehad Ismail, Suhad Saad Mahmoud
Background and Objectives: Multidrug resistance and in particular, carbapenem resistant Gram-negative bacteria is spreading worldwide at an alarming rate. Among the clinically significant carbapenemases, the New Delhi Metallo-β-lactamase (NDM) is one of the most formidable. NDM efficiently hydrolyses β-lactams and is the last-resort among carbapenems. Hence, therapeutic options for NDM producer bacteria become restricted to a handful of antibiotics. The present study was undertaken to detect the prevalence of the bla NDM -variants Metallo β-lactamases (MBLs) among isolates of Pseudomonas aeruginosa recovered from various clinical samples of hospitalized patients in Baghdad, Iraq...
April 2018: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29992522/correction-to-a-challenging-case-of-carbapenemase-producing-klebsiella-pneumoniae-septic-thrombophlebitis-and-right-mural-endocarditis-successfully-treated-with-ceftazidime-avibactam
#9
Alessandra Iacovelli, Martina Spaziante, Samir Al Moghazi, Alessandra Giordano, Giancarlo Ceccarelli, Mario Venditti
The given names and family names of all authors were transposed in the original publication. The original article has been corrected.
July 10, 2018: Infection
https://www.readbyqxmd.com/read/29987921/prevalence-and-characterization-of-carbapenem-resistant-bacteria-in-water-bodies-in-the-los-angeles-southern-california-area
#10
Dana E Harmon, Osvaldo A Miranda, Ashley McCarley, Michelle Eshaghian, Natasha Carlson, Cristian Ruiz
Carbapenems are β-lactam antibiotics used in healthcare settings as last resort drugs to treat infections caused by antibiotic-resistant bacteria. Carbapenem-resistant bacteria are increasingly being isolated from healthcare facilities; however, little is known about their distribution or prevalence in the environment, especially in the United States, where their distribution in water environments from the West Coast has not been studied before. The aim of this study was to determine the prevalence of carbapenem-resistant bacteria and carbapenemase genes in water bodies from the Los Angeles area (California, USA)...
July 10, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29986025/vim-imp-carbapenemase-producing-enterobacteriaceae-in-poland-epidemic-enterobacter-hormaechei-and-klebsiella-oxytoca-lineages
#11
R Izdebski, A Baraniak, D Zabicka, A Sekowska, E Gospodarek-Komkowska, W Hryniewicz, M Gniadkowski
Objectives: To analyse VIM/IMP-type MBL-producing Enterobacteriaceae isolates identified in Poland during 2006-12. Methods: Isolates were typed by PFGE, followed by MLST. blaVIM/IMP genes were amplified and sequenced within class 1 integrons. Their plasmidic versus chromosomal location was assessed by nuclease S1 and I-CeuI plus hybridization experiments. Plasmids were characterized by transfer assays and PCR-based replicon typing. Results: One hundred and nineteen VIM/IMP-positive Enterobacteriaceae cases were reported in Poland from the first case in 2006 until 2012...
July 6, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29983287/sequence-heterogeneity-of-the-pena-carbapenemase-in-clinical-isolates-of-burkholderia-multivorans
#12
Scott A Becka, Elise T Zeiser, Steven H Marshall, Julian A Gatta, Kevin Nguyen, Indresh Singh, Chris Greco, Granger G Sutton, Derrick E Fouts, John J LiPuma, Krisztina M Papp-Wallace
Multidrug-resistant gram-negative pathogens are a significant health threat. Burkholderia spp. encompass a complex subset of gram-negative bacteria with a wide range of biological functions that include human, animal, and plant pathogens. The treatment of infections caused by Burkholderia spp. is problematic due to their inherent resistance to multiple antibiotics. The major β-lactam resistance determinant expressed in Burkholderia spp. is a class A β-lactamase of the PenA family. In this study, significant amino acid sequence heterogeneity was discovered in PenA (37 novel variants) within a panel of 48 different strains of Burkholderia multivorans isolated from individuals with cystic fibrosis...
June 18, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29983286/evaluation-of-the-cre-and-esbl-elite-mgb%C3%A2-kits-for-the-accurate-detection-of-carbapenemase-or-ctx-m-producing-bacteria
#13
Delphine Girlich, Sandrine Bernabeu, Nicolas Fortineau, Laurent Dortet, Thierry Naas
As carbapenemase-producing Enterobacteriaceae (CPE) and extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are becoming a major public health issue, there is an urgent need for accurate and fast diagnostic tests. The ELITe InGenius is a fully automated sample-to-result system designed for the extraction and detection by multiplex real-time polymerase chain reaction of carbapenemases KPC, NDM, VIM, IMP, and OXA-48-like variants and CTX-M group 1 and 9-producers from diverse sample matrices such as colonies, positive blood cultures, and rectal swabs...
February 9, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29980699/diversity-among-bla-kpc-containing-plasmids-in-escherichia-coli-and-other-bacterial-species-isolated-from-the-same-patients
#14
Tracy H Hazen, Roberta Mettus, Christi L McElheny, Sarah L Bowler, Sushma Nagaraj, Yohei Doi, David A Rasko
Carbapenem resistant Enterobacteriaceae are a significant public health concern, and genes encoding the Klebsiella pneumoniae carbapenemase (KPC) have contributed to the global spread of carbapenem resistance. In the current study, we used whole-genome sequencing to investigate the diversity of blaKPC -containing plasmids and antimicrobial resistance mechanisms among 26 blaKPC -containing Escherichia coli, and 13 blaKPC -containing Enterobacter asburiae, Enterobacter hormaechei, K. pneumoniae, Klebsiella variicola, Klebsiella michiganensis, and Serratia marcescens strains, which were isolated from the same patients as the blaKPC -containing E...
July 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29979638/high-prevalence-of-vim-kpc-and-ndm-expression-among-surgical-site-infection-pathogens-in-patients-having-emergency-surgery
#15
Amani A El-Kholy, Mervat G Elanany, May M Sherif, Maha A Gad
BACKGROUND: The rate of surgical site infection (SSI) in patients who undergo emergency operations is higher than in other patients. Previous studies showed an increasing role of gram- negative pathogens (GNP) in SSI. We aimed to identify GNP causing SSIs after emergency surgery, to characterize the carbapenemase-resistance genes in carbapenem-resistant pathogens (CRPs), and to identify the risk factors for SSI caused by CRP. METHOD: We conducted a one-year prospective study from September 2014 in the Emergency Hospital of Cairo University Hospitals...
July 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29974720/resistance-of-uropathogens-to-antibacterial-agents-emerging-threats-trends-and-treatments
#16
Gianpaolo Perletti, Vittorio Magri, Tommaso Cai, Konstantinos Stamatiou, Alberto Trinchieri, Emanuele Montanari
Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies...
June 30, 2018: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29970918/emergence-and-spread-of-carbapenem-resistant-acinetobacter-baumannii-international-clones-ii-and-iii-in-lima-peru
#17
Saúl Levy-Blitchtein, Ignasi Roca, Stefany Plasencia-Rebata, William Vicente-Taboada, Jorge Velásquez-Pomar, Laura Muñoz, Javier Moreno-Morales, Maria J Pons, Juana Del Valle-Mendoza, Jordi Vila
Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 non-duplicate clinical samples of A...
July 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29970891/emergence-of-a-novel-mobile-colistin-resistance-gene-mcr-8-in-ndm-producing-klebsiella-pneumoniae
#18
Xiaoming Wang, Yao Wang, Ying Zhou, Jiyun Li, Wenjuan Yin, Shaolin Wang, Suxia Zhang, Jianzhong Shen, Zhangqi Shen, Yang Wang
The rapid increase in carbapenem resistance among gram-negative bacteria has renewed focus on the importance of polymyxin antibiotics (colistin or polymyxin E). However, the recent emergence of plasmid-mediated colistin resistance determinants (mcr-1, -2, -3, -4, -5, -6, and -7), especially mcr-1, in carbapenem-resistant Enterobacteriaceae is a serious threat to global health. Here, we characterized a novel mobile colistin resistance gene, mcr-8, located on a transferrable 95,983-bp IncFII-type plasmid in Klebsiella pneumoniae...
July 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29969691/point-prevalence-survey-of-carbapenemase-producing-enterobacteriaceae-cpe-and-vancomycin-resistant-enterococci-vre-in-adult-inpatients-in-a-university-teaching-hospital-in-the-united-kingdom
#19
Hayley J Wilson, Fahad Khokhar, David A Enoch, Nicholas M Brown, Jag Ahluwalia, Gordon Dougan, M Estée Török
Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with increased morbidity and mortality, but the carriage rates of CRE and VRE among hospital inpatients is unknown. We conducted a point-prevalence survey to determine CPE and VRE carriage rates in hospitalised adults. 818/960 (85.2%) adult inpatients were invited to participate in the study. 595/818 (72.7%) consented and provided specimens. Of 540 samples tested, none were positive for CPE...
June 30, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29967023/spread-of-bla-ctx-m-15-producing-enterobacteriaceae-and-oxa-23-producing-acinetobacter-baumannii-st2-in-tunisian-seafood
#20
Yosra Mani, Wejdene Mansour, Agnese Lupo, Estelle Saras, Olfa Bouallègue, Jean-Yves Madec, Marisa Haenni
Bivalves are filter-feeding animals and markers of bacterial pollution. We report a massive spread of bla CTX-M-15 through dominant E. coli and K. pneumoniae lineages and/or plasmid subtypes (F31:A4:B1) as well as OXA-23-producing Acinetobacter baumannii ST2 in seafood, highlighting a direct risk for the consumer. These findings should urge authorities to consider hospital effluents, but also farm and urban effluents, as important sources of ESBL/carbapenemase-producers that filter-feeding animals can concentrate and further spread to humans...
July 2, 2018: Antimicrobial Agents and Chemotherapy
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