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https://www.readbyqxmd.com/read/28642759/biodistribution-and-efficacy-of-human-adipose-derived-mesenchymal-stem-cells-following-intranodal-administration-in-experimental-colitis
#1
Mercedes Lopez-Santalla, Pablo Mancheño-Corvo, Amelia Escolano, Ramon Menta, Olga DelaRosa, Jose Luis Abad, Dirk Büscher, Juan M Redondo, Juan A Bueren, Wilfried Dalemans, Eleuterio Lombardo, Marina I Garin
Mesenchymal stem cells (MSCs) have a large potential in cell therapy for treatment of inflammatory and autoimmune diseases, thanks to their immunomodulatory properties. The encouraging results in animal models have initiated the translation of MSC therapy to clinical trials. In cell therapy protocols with MSCs, administered intravenously, several studies have shown that a small proportion of infused MSCs can traffic to the draining lymph nodes (LNs). This is accompanied with an increase of different types of regulatory immune cells in the LNs, suggesting the importance of migration of MSCs to the LNs in order to contribute to immunomodulatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28642658/study-of-the-anterolateral-ligament-of-the-knee-in-formalin-embedded-cadavers
#2
Paloma Batista Almeida Fardin, Juliana Hott de Fúcio Lizardo, Josemberg da Silva Baptista
OBJECTIVE: To verify the incidence and characterize morphologically the anterolateral ligament of the knee (ALL) in cadaveric samples of the collection of the Laboratory of Anatomy of the Department of Morphology of the Universidade Federal do Espírito Santo. METHODS: Dissections and cross sections were performed for mesoscopic analysis of the anterolateral region of 15 knees preserved in 4% formalin solution in order to identify the ALL. RESULTS: After dissection of the skin and subcutaneous tissue of the knee anterolateral region, it was possible to identify the iliotibial tract (ITT), the patellar ligament and the femoral biceps tendon...
March 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28639874/compression-treatment-of-pelvic-congestion-syndrome
#3
S G Gavrilov, A V Karalkin, O O Turischeva
Aim To study the influence of compression treatment on clinical manifestations and venous hemodynamics of the pelvis in patients with pelvic congestion syndrome. Materials and methods A prospective study of the various options and modes of compression treatment was carried out and included 74 patients with pelvic congestion syndrome in 2008-2015. The patients were divided into three groups. The first group consisted of 48 patients with symptoms of pelvic congestion syndrome and chronic pelvic pain. They used Class II compression shorts...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28634522/popliteal-arterial-thrombosis-in-nephrotic-syndrome-a-case-report
#4
Niranjan Tachamo, Rashmi Dhital, Bidhya Timilsina, Salik Nazir, Saroj Lohani, Dilli Ram Poudel
Thrombosis is a frequent cause of morbidity and mortality in patients with nephrotic syndrome (NS). Though venous thromboses are common in NS, arterial thromboses are relatively rare. Commonly involved arteries include coronary, iliac, femoral, renal, cerebral, pulmonary, mesenteric, and axillary arteries, and the aorta. Arterial thromboses are associated with poor prognosis; treatment options are limited and patients may not always be amenable to treatment. We present the case of a 39-year-old female with NS who presented with thigh pain and was found to have sub-acute popliteal artery thrombosis...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28633610/popliteal-artery-entrapment-syndrome-presenting-as-raynaud-phenomenon
#5
Braden Passias, Sean Lyden, Amanda Frederick, Michael Jolly, Mitchell J Silver
No abstract text is available yet for this article.
June 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28633148/clinical-and-functional-results-of-119-patients-with-knee-dislocations
#6
Nicholas R Scarcella, Douglas S Weinberg, Stephen Bowen, Heather A Vallier
OBJECTIVES: To describe clinical results and functional outcomes of knee dislocations treated with a consistent strategy within our institution. DESIGN: Retrospective case series. SETTING: Level 1 trauma center. PATIENTS: One hundred nineteen patients were treated at one institution between 2000 and 2014 for knee dislocation. MAIN OUTCOME MEASUREMENTS: Knee range of motion, functional instability, and complications were recorded...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28629556/drug-eluting-balloons-for-treatment-of-sfa-and-popliteal-disease-a-review-of-current-status
#7
REVIEW
Jos C van den Berg
The endovascular treatment of atherosclerotic disease of the infra-inguinal arteries has changed significantly over the last decades. In an attempt to overcome the high restenosis rates that characterize plain balloon angioplasty and stenting using bare mate stents drug-eluting balloon technology has been applied in the treatment of lesions of the superficial femoral and popliteal artery. This paper will give an overview of the rationale and the technology of drug-eluting balloons and will review currently available data from registries and randomized controlled trials...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28627865/the-value-of-color-doppler-ultrasound-in-the-diagnosis-of-lower-extremity-vascular-disease-in-type-2-diabetes-and-an-analysis-of-related-factors
#8
Le Jiang, Yuehua Zhao
BACKGROUND: The aim of this paper is to explore the application and clinical significance of color Doppler ultrasound (CDU) in diagnosing lower extremity vascular disease in type 2 diabetes mellitus (T2DM) patients. METHODS: The lower extremity arteries of 81 patients with T2DM and 50 control patients were examined by CDU for blood vessel diameter, intima-media thickness, plaque on the vessel wall, lumen stenosis and filling defect in blood flow. The occurrence of diabetes mellitus was investigated in additional T2DM patients of various ages...
September 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28625661/resting-limb-muscle-perfusion-during-inspiratory-muscle-loading-in-hypoxia-and-normoxia
#9
Hannes Klenze, Thomas Christian Köhler, Franziska Farquharson, Stephan Walterspacher, Daniel Duerschmied, Kai Roecker, Hans-Joachim Kabitz, David Johannes Walker
INTRODUCTION: Fatiguing of respiratory muscles reduces peripheral muscle perfusion. Further, acute hypoxia enhances respiratory muscle fatigue. This study investigated the effects of inspiratory muscle loading (IML) on resting locomotor muscle perfusion in hypoxia compared to normoxia. METHODS: Ten subjects completed two study days of fatiguing IML (blinded, randomized) in normobaric hypoxia (targeted oxygen saturation 80%) and normoxia, respectively. Contrast-enhanced ultrasound (CEUS) of the gastrocnemius muscle and popliteal doppler ultrasonography were used to monitor muscle perfusion...
June 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28615848/therapeutic-management-of-canine-ehrlichiosis-with-aid-of-blood-transfusion-a-case-report
#10
Arjun Kasondra, Snehil Gupta, Gamit Amit Bhai Bharat Bhai, Vijesh Kumar Saini
An adult female Labrador Retriever dog was presented at referral veterinary polyclinic, IVRI in lateral recumbency with history of anorexia, high fever, severe panting, heavy tick infestation, and not responding to cephalosporins and fluoroquinolones since last 1 week. Clinical examination showed pale conjunctiva, enlarged popliteal lymph node however, electrocardiogram (ECG) report found to be normal. Haematological finding showed marked anaemia and thrombocytopenia. Parasitological examination found it to be positive for Ehrlichia canis and confirmed ticks to be Rhipicephalus sanguineus...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28607786/proximal-tibial-epiphysis-fracture-in-a-13-year-old-male-athlete
#11
Ioannis M Stavrakakis, Pavlos E Katsoulis, Maria S Katsafarou
Fractures of the proximal epiphysis of the tibia are rare, representing 0.5 to 3.0% of all epiphyseal injuries. These injuries can damage the popliteal vessels and their bifurcation, affecting the blood supply of the lower limb, as well as the nerves below the knee. Epiphyseal growth arrest is also a potential complication, leading to various angular deformities. We present a case of a 13-year-old male athlete with a posteriorly displaced Salter-Harris type II fracture of the proximal epiphysis of the left tibia who was treated conservatively with closed reduction and cast immobilization...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28607288/role-of-routine-pre-operative-screening-venous-duplex-ultrasound-in-morbidly-obese-patients-undergoing-bariatric-surgery
#12
P Praveen Raj, Rachel M Gomes, Saravana Kumar, Palanisamy Senthilnathan, Ramakrishnan Parathasarathi, Subbiah Rajapandian, Chinnusamy Palanivelu
BACKGROUND/AIMS: It is well established that obesity is a strongly associated risk factor for post-operative deep vein thrombosis (DVT). Physical effects and pro-thrombotic, pro-inflammatory and hypofibrinolytic effects of severe obesity may predispose to idiopathic DVT (pre-operatively) because of which bariatric patients are routinely screened before surgery. The aim of this study was to audit the use of routine screening venous duplex ultrasound in morbidly obese patients before undergoing bariatric surgery...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28604330/infection-and-tissue-repair-of-experimental-cutaneous-candidiasis-in-diabetic-mice
#13
Andréia Carla Eugenio Pupim, Tacito Graminha Campois, Eduardo José de Almeida Araújo, Terezinha Inez Estivalet Svidizinski, Ionice Felipe
PURPOSE: Diabetic patients seem to be predisposed to cutaneous candidiasis. In this study, we evaluated the interference of diabetic conditions in alloxan-induced diabetic mice in relation to the development of C. albicans infection, density of M1 and M2 macrophages, distribution of collagen type I and III and anti-inflamamatory cytokines involved in tissue repair. METHODOLOGY: The mice were treated with intravenous alloxan, and all animals with blood glucose levels >250  mg dl-1 were inoculate with C...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28602901/endovascular-treatment-of-aorto-iliac-femoral-anastomotic-pseudoaneurysms-a-multicentric-study
#14
D Laganà, G Guzzardi, M Petullà, M Martelli, A M Ierardi, B Del Sette, G Carrafiello
PURPOSE: Purpose of this study is to assess the effectiveness of anastomotic pseudoaneurysms (APAs) endovascular treatment following aorto-iliac-femoral surgical reconstruction. BASIC PROCEDURES: We retrospectively evaluated 54 patients that underwent aorto-iliac-femoral by-pass (72 APAs). Follow up was performed with Eco-color-Doppler and/or CTA at 1, 3, 6 months after the procedure and than yearly.We compared clinical success in terms of mortality between aortic APAs and non-aortic APAs (iliac-femoral-popliteal)...
June 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28600622/functional-popliteal-artery-entrapment-syndrome-use-of-ultrasound-guided-botox-injection-as-a-non-surgical-treatment-option
#15
Matthew Hislop, Adam Brideaux, Sanjay Dhupelia
OBJECTIVE: To determine whether ultrasound-guided injection of botulinum toxin type A (BTX-A) is a viable alternative to surgical intervention for the treatment of functional popliteal artery entrapment syndrome (PAES). MATERIALS AND METHODS: Twenty-seven patients met diagnostic criteria confirming the presence of functional PAES and agreed to go ahead with ultrasound-guided BTX-A injection at the level of artery occlusion. Patients were assessed and treated at baseline and given the option for 'top-up' injections at 6 and 12 months...
June 9, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28598917/improving-performance-by-monitoring-the-success-rate-of-peripheral-nerve-blocks
#16
Sietske M K Bakker, Rudolf Stienstra
In our hospital, we introduced a system to measure the collective and individual efficacy of brachial plexus and popliteal nerve blocks with the objective to create transparency as an instrument for monitoring and improvement. Initially, individual results were anonymous, but after 1 year anonymity was lifted within the team of anesthesiologists and results are now discussed quarterly. Collective performance of interscalene, supraclavicular, and popliteal blocks improved significantly over time. Sharing and discussing collective and individual performance has resulted in critical self-appraisal and increased willingness to learn from each other and strengthened the team's ambition for further improvement...
June 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28597743/one-year-results-of-primary-stenting-for-tasc-ii-d-lesions-of-the-superficial-femoral-and-popliteal-arteries
#17
Mehmet Ali Astarcıoglu, Celal Kılıt, Taner Sen, Halil Ibrahim Durmus, Macit Kalcık, Mustafa Ozan Gursoy, Mahmut Yesın, Lale Dinc Asarcıklı, Gokhan Gozubuyuk, Basri Amasyalı
Objective This study aimed to evaluate the safety and the efficacy of primary stenting to treat Trans-Atlantic Inter-Society Consensus II (TASC) D femoropopliteal lesions. Background Advances in wire, balloon and stent design have been reported to improve the durability of stenting of longer femoropopliteal lesions. Methods A total of 57 limbs of 53 patients with Rutherford stage 3 to 6 due to TASC D femoropopliteal lesions were treated with a self-expanding nitinol stent in a prospective, single-centre, observational study...
February 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28595481/retrograde-popliteal-access-to-percutaneous-peripheral-intervention-for-chronic-total-occlusion-of-superficial-femoral-arteries
#18
Mert Dumantepe
OBJECTIVE: The aim of this study is to present our initial experience with the use of the retrograde popliteal artery access in patients with chronic total occlusions of superficial femoral artery (SFA). METHOD: From July 2012 to May 2014, a total of 28 patients (20 men, mean age 61.2 ± 11.5 years) with total occlusion of the SFA and good distal runoff were treated with percutaneous atherectomy, balloon angioplasty, and stenting (mean length 165.3 ± 57.5 mm, range 72-336 mm)...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28589159/demographics-and-injuries-associated-with-knee-dislocation-a-prospective-review-of-303-patients
#19
Gilbert Moatshe, Grant J Dornan, Sverre Løken, Tom C Ludvigsen, Robert F LaPrade, Lars Engebretsen
BACKGROUND: Information on the incidence, injury mechanisms, ligament injury patterns, and associated injuries of knee dislocations is lacking in the literature. There is a need to characterize ligament injury patterns and associated injuries in knee dislocations to avoid missing common associated diagnoses and to plan surgical treatment. PURPOSE: To evaluate patient demographics, ligament injury patterns and associated injury patterns, and associated injuries in patients with knee dislocation...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28587797/comparison-of-long-term-outcomes-of-heparin-bonded-polytetrafluoroethylene-and-autologous-vein-below-knee-femoropopliteal-bypasses-in-patients-with-critical-limb-ischaemia
#20
C Uhl, C Grosch, C Hock, I Töpel, M Steinbauer
OBJECTIVE/BACKGROUND: Endovascular first is the preferred therapy approach to critical limb ischaemia (CLI). However, in spite of new endovascular techniques, bypass surgery still plays an important role, especially in patients with complex anatomy in whom endovascular therapy is not considered feasible, or has failed. The goal of this study was to analyse the outcomes of prosthetic or autologous vein for femoropopliteal (P3) bypasses performed under the abovementioned conditions. METHODS: A retrospective analysis of patients who underwent a femoropopliteal (P3) bypass for CLI (March 2007-December 2015) was conducted...
June 3, 2017: European Journal of Vascular and Endovascular Surgery
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