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https://www.readbyqxmd.com/read/27909394/metabolic-energy-of-action-potentials-modulated-by-spike-frequency-adaptation
#1
Guo-Sheng Yi, Jiang Wang, Hui-Yan Li, Xi-Le Wei, Bin Deng
Spike frequency adaptation (SFA) exists in many types of neurons, which has been demonstrated to improve their abilities to process incoming information by synapses. The major carrier used by a neuron to convey synaptic signals is the sequences of action potentials (APs), which have to consume substantial metabolic energies to initiate and propagate. Here we use conductance-based models to investigate how SFA modulates the AP-related energy of neurons. The SFA is attributed to either calcium-activated K(+) (IAHP) or voltage-activated K(+) (IM) current...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27908309/an-unrecognised-presentation-of-takayasu-arteritis-superficial-femoral-artery-involvement
#2
Hui Dong, Wuqiang Che, Xiongjing Jiang, Meng Peng, Yubao Zou, Huimin Zhang, Bo Xu, Yuejin Yang, Runlin Gao
OBJECTIVES: Superficial femoral artery (SFA) involvement in Takayasu arteritis (TA) has rarely been reported. The purpose of this study was to investigate the clinical characteristic and clinical outcomes of endovascular therapy in such patients. METHODS: We analysed the data collected from 105 consecutive patients with TA, who were diagnosed from January 2011 to December 2013. All patients underwent ankle brachial index (ABI) measurements and angiography. Nine patients with an ABI <0...
November 18, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27907021/the-effects-of-long-term-saturated-fat-enriched-diets-on-the-brain-lipidome
#3
Corey Giles, Ryusuke Takechi, Natalie A Mellett, Peter J Meikle, Satvinder Dhaliwal, John C Mamo
The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have investigated the interplay between plasma lipid homeostasis relative to cerebral lipids. This study explored whether changes in plasma lipids induced by chronic consumption of a well-tolerated diet enriched in saturated fatty acids (SFA) was associated with parallel changes in cerebral lipid homeostasis...
2016: PloS One
https://www.readbyqxmd.com/read/27906983/tithonia-diversifolia-as-a-supplementary-feed-for-dairy-cows
#4
Rafael Sandin Ribeiro, Stephanie Amelia Terry, João Paulo Sacramento, Sylvia Rocha E Silveira, Cláudia Braga Pereira Bento, Elsa Fernandes da Silva, Hilário Cuquetto Mantovani, Marco Antônio Sundfeld da Gama, Luiz Gustavo Ribeiro Pereira, Thierry Ribeiro Tomich, Rogério Martins Maurício, Alexandre Vieira Chaves
The objective of this study was to examine the effects of Tithonia diversifolia as a supplementary forage on dairy cow performance and methane production. Nine lactating Holstein × Zebu dairy cows (519 ± 53.3 kg of body weight and 66 ± 13.3 d in milk) were paired by milk yield (21.3 ± 2.34 kg/d) and body weight and randomly assigned to three dietary treatments in a Latin square design with 21-d experimental periods (14 d for diet adaptation and 7 d for measurements and sample collection). The dietary treatments included the control diet consisting of fresh sugar cane plus concentrate (44:56, % of diet DM), and two treatment diets containing different levels of fresh T...
2016: PloS One
https://www.readbyqxmd.com/read/27903467/arterio-cutaneous-fistula-associated-with-bilateral-femoral-pseudoaneurysms-caused-by-bacillus-calmette-gu%C3%A3-rin-apropos-of-a-case-and-review-of-literature
#5
Álvaro Torres-Blanco, Francisco Gómez-Palonés, Gemma Edo-Fleta
Vascular complications of intravesical instillation of bacillus Calmette-Guérin (BCG) are rare. BCG is an attenuated strain of Mycobacterium bovis (M. Bovis) that was initially developed for vaccination against tuberculosis, but it has also been used as an adjuvant treatment for bladder transitional carcinoma. We report a patient with a history of instillation of BCG two years before, who underwent surgical treatment of 2 pseudoaneurysms. The first, located in the left superficial femoral artery (SFA), was resected and the artery was ligated because he had a history of femoropopliteal occlusion...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27900351/data-for-differentially-expressed-micrornas-in-saturated-fatty-acid-palmitate-treated-hepg2-cells
#6
Won-Mo Yang, Kyung-Ho Min, Wan Lee
Certain microRNAs (miRNAs) targeting the molecules in the insulin signaling cascades are dysregulated by saturated fatty acids (SFA), which can lead to insulin resistance and type 2 diabetes. This article reports the accompanying data collected using miRNAs microarrays to identify the changes in miRNA expression in HepG2 cells treated with SFA palmitate. Differentially expressed miRNA analyses in HepG2 cells showed that a range of upregulated (>1.5-fold) or downregulated (<0.5-fold) miRNAs. Further extensive insights into the implications of miRNAs, particularly miR-1271, in HepG2 cells can be found in "MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells" (W...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27899146/impact-of-visceral-fat-on-gene-expression-profile-in-peripheral-blood-cells-in-obese-japanese-subjects
#7
Yoshinari Obata, Norikazu Maeda, Yuya Yamada, Koji Yamamoto, Seiji Nakamura, Masaya Yamaoka, Yoshimitsu Tanaka, Shigeki Masuda, Hirofumi Nagao, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Ken-Ichi Matsubara, Yuji Matsuzawa, Iichiro Shimomura
BACKGROUND: Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the effects of visceral fat area (VFA) and subcutaneous fat area (SFA) on the gene expression profile in peripheral blood cells of obese subjects...
November 29, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27898904/feeding-microalgae-meal-all-g-rich-ccap-4087-2-to-beef-heifers-i-effects-on-longissimus-lumborum-steak-color-and-palatibility
#8
K J Phelps, J S Drouillard, T G O'Quinn, D D Burnett, T L Blackmon, J E Axman, C L Van Bibber-Krueger, J M Gonzalez
The objective of this study was to examine effects of 4 levels of microalgae meal (All-G Rich, CCAP 4087/2; Alltech Inc., Nicholasville, KY) supplementation to the diet of finishing heifers on longissimus lumborum (LL) steak PUFA content, beef palatability, and color stability. Crossbred heifers ( = 288; 452 ± 23 kg initial BW) were allocated to pens (36 pens and 8 heifers/pen), stratified by initial pen BW (3,612 ± 177 kg), and randomly assigned within strata to 1 of 4 treatments: 0, 50, 100, and 150 g·heifer·d of microalgae meal...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898842/inferring-phenotypic-causal-structures-among-meat-quality-traits-and-the-application-of-a-structural-equation-model-in-japanese-black-cattle
#9
K Inoue, B D Valente, N Shoji, T Honda, K Oyama, G J M Rosa
Meat quality is one of the most important traits determining carcass price in the Japanese beef market. Optimized breeding goals and management practices for the improvement of meat quality traits requires knowledge regarding any potential functional relationships between them. In this context, the objective of this research was to infer phenotypic causal networks involving beef marbling score (BMS), beef color score (BCL), firmness of beef (FIR), texture of beef (TEX), beef fat color score (BFS), and the ratio of MUFA to SFA (MUS) from 11,855 Japanese Black cattle...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27888619/tetraspanin-cd151-as-an-emerging-potential-poor-prognostic-factor-across-solid-tumors-a-systematic-review-and-meta-analysis
#10
REVIEW
Ping Zeng, Yin-Hua Wang, Meng Si, Jin-Hua Gu, Ping Li, Pei-Hua Lu, Min-Bin Chen
Tetraspanin CD151, also known as PETA-3 or SFA-1, has been reported to predict prognosis in various solid tumors. Yet, the results of these studies remained inconclusive. Here, we performed this meta-analysis of relevant studies published on the topic to quantitatively evaluate the clinicopathological significance of CD151 in solid tumors. The relevant articles were identified via searching the PubMed, Web of Science and Embase database. The pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CI) of overall survival (OS) and disease-free survival (DFS) were calculated to evaluate the prognostic value of CD151 expression in patients with solid tumors...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887752/changes-in-plasma-fatty-acid-composition-are-associated-with-improvements-in-obesity-and-related-metabolic-disorders-a-therapeutic-approach-to-overweight-adolescents
#11
Marcela Guerendiain, Rosa Montes, Gemma López-Belmonte, Miguel Martín-Matillas, Ana I Castellote, Elena Martín-Bautista, Amelia Martí, J Alfredo Martínez, Luis Moreno, Jesús Mª Garagorri, Julia Wärnberg, Javier Caballero, Ascensión Marcos, M Carmen López-Sabater, Cristina Campoy
BACKGROUND & AIMS: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents...
November 11, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27884360/cost-effectiveness-of-endovascular-femoropopliteal-intervention-using-drug-coated-balloons%C3%A2-versus-standard-percutaneous-transluminal-angioplasty-results-from-the-in-pact%C3%A2-sfa-ii-trial
#12
Adam C Salisbury, Haiyan Li, Katherine R Vilain, Michael R Jaff, Peter A Schneider, John R Laird, David J Cohen
OBJECTIVES: The aim of this study was to evaluate the cost-effectiveness of drug-coated balloon (DCB) angioplasty versus standard percutaneous transluminal angioplasty (PTA). BACKGROUND: Recent trials have reported lower rates of target lesion revascularization with DCB angioplasty versus standard PTA. However, the cost-effectiveness of DCB angioplasty is unknown. METHODS: A prospective economic study was performed alongside the IN.PACT SFA II (IN...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27884102/gene-expression-profile-of-intramuscular-muscle-in-nellore-cattle-with-extreme-values-of-fatty-acid
#13
Mariana P Berton, Larissa F S Fonseca, Daniela F J Gimenez, Bruno L Utembergue, Aline S M Cesar, Luiz L Coutinho, Marcos Vinicius A de Lemos, Carolyn Aboujaoude, Angélica S C Pereira, Rafael M de O Silva, Nedenia B Stafuzza, Fabieli L B Feitosa, Hermenegildo L J Chiaia, Bianca F Olivieri, Elisa Peripolli, Rafael L Tonussi, Daniel M Gordo, Rafael Espigolan, Adrielle M Ferrinho, Lenise F Mueller, Lucia G de Albuquerque, Henrique N de Oliveira, Susan Duckett, Fernando Baldi
BACKGROUND: Fatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique. RESULTS: Differential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27881409/intake-of-individual-saturated-fatty-acids-and-risk-of-coronary-heart-disease-in-us-men-and-women-two-prospective-longitudinal-cohort-studies
#14
Geng Zong, Yanping Li, Anne J Wanders, Marjan Alssema, Peter L Zock, Walter C Willett, Frank B Hu, Qi Sun
OBJECTIVES:  To investigate the association between long term intake of individual saturated fatty acids (SFAs) and the risk of coronary heart disease, in two large cohort studies. DESIGN:  Prospective, longitudinal cohort study. SETTING:  Health professionals in the United States. PARTICIPANTS:  73 147 women in the Nurses' Health Study (1984-2012) and 42 635 men in the Health Professionals Follow-up Study (1986-2010), who were free of major chronic diseases at baseline...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27871847/fatty-acids-composition-in-erythrocyte-membranes-of-athletes-after-one-and-after-a-series-of-whole-body-cryostimulation-sessions
#15
Magdalena Kepinska, Joanna Gdula-Argasinska, Zbigniew Dabrowski, Marta Szarek, Wanda Pilch, Agnieszka Kreska-Korus, Zbigniew Szygula
Whole body cryotherapy (WBC) is a treatment often used by athletes as part of biological renewal. Despite the large interest in this form therapy there is still a lack of information on the effects of WBC on the concentration of fatty acids in erythrocyte membranes. Our study aimed at comparing the fatty acids (FA) composition of erythrocyte membranes of athletes after one session and after a series of sessions of whole body cryostimulation. In our study small changes in the level of total cholesterol (decrease) were observed 24 h after a single session...
November 18, 2016: Cryobiology
https://www.readbyqxmd.com/read/27868245/the-influence-of-sex-and-gonadectomy-on-hepatic-and-brain-fatty-acid-composition-lipogenesis-and-%C3%AE-oxidation
#16
K Starčević, N Filipović, M Šperanda, M Đidara, T Mašek
The aim of this study was to investigate the influence of sex and castration of rats on liver and brain fatty acid profile and liver mRNA expression of genes involved in lipogenesis and β-oxidation. Castration significantly increased body weight and liver index and decreased serum triglyceride content in the female rats. The fatty acid composition of the liver tissue was influenced by sex and castration. Male rats had higher content of C16:0, C18:1n7, C18:2n6 and C22:5n3, while female rats had higher content of C18:0, C20:4n6 and C22:6n3...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27865639/a-network-meta-analysis-of-randomized-controlled-trials-comparing-treatment-modalities-for-de-novo-superficial-femoral-artery-occlusive-lesions
#17
REVIEW
Constantine N Antonopoulos, Spyridon N Mylonas, Konstantinos G Moulakakis, Theodoros N Sergentanis, George S Sfyroeras, Andreas M Lazaris, John D Kakisis, Spyros N Vasdekis
BACKGROUND: Treatment of superficial femoral artery (SFA) lesions remains challenging. We conducted a network meta-analysis of randomized controlled trials aiming to explore the efficacy of treatment modalities for SFA "de novo" lesions. METHODS: Eleven treatments for SFA occlusive disease were recognized. We used primary patency and binary restenosis at 12-month follow-up as proxies of efficacy for the treatment of SFA lesions. RESULTS: A total of 33 studies (66 study arms; 4659 patients) were deemed eligible...
November 16, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27865260/antimicrobial-resistance-and-molecular-characterization-of-virulence-genes-phylogenetic-groups-of-escherichia-coli-isolated-from-diarrheic-and-healthy-camel-calves-in-tunisia
#18
Salma Bessalah, John Morris Fairbrother, Imed Salhi, Ghyslaine Vanier, Touhami Khorchani, Mouldi Mabrouk Seddik, Mohamed Hammadi
This study was conducted to determine the prevalence of virulence genes, serogroups, antimicrobial resistance and phylogenetic groups of Escherichia coli strains isolated from diarrheic and healthy camel calves in Tunisia. From 120 fecal samples (62 healthy and 58 diarrheic camel calves aged less than 3 months), 70 E. coli isolates (53 from diarrheic herds and 17 from healthy herds) were examined by PCR for detection of the virulence genes associated with pathogenic E. coli in animals. A significantly greater frequency of the f17 gene was observed in individual camels and in herds with diarrhea, this gene being found in 44...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27857546/comparison-of-meat-quality-and-fatty-acid-composition-of-longissimus-muscles-from-purebred-pigs-and-three-way-crossbred-lyd-pigs
#19
Yeong-Seok Choi, Jin-Kyu Lee, Ji-Taek Jung, Young-Chul Jung, Jong-Hyun Jung, Myung-Ok Jung, Yang-Il Choi, Sang-Keun Jin, Jung-Seok Choi
This study was conducted to find pork quality to meet the needs of consumers. Thus, the meat quality and fatty acid composition of longissimus muscles from purebred pigs (Landrace, Yorkshire, and Duroc) and three-way crossbred LYD pigs were compared and evaluated. Chemical compositions of longissimus muscles were significant (p<0.05) different among pigs. Duroc contained significant (p<0.05) higher fat contents than other pigs, whereas significant (p<0.05) higher moisture contents were observed in Landrace, Yorkshire, and LYD pigs compared to those of Duroc pigs...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27857545/fatty-acid-profiles-of-ten-muscles-from-high-and-low-marbled-quality-grade-1-and-2-hanwoo-steers
#20
Young-Hwa Hwang, Seon-Tea Joo
The aim of this research was to evaluate: 1) the fatty acid profile of ten muscles from high marbled (HM, quality grade 1(++)) and low marbled (LM, quality grade 2) Hanwoo carcass, 2) the relationship between the fatty acid profile and sensory traits. There were significant (p<0.001) differences in fat content and fatty acid composition among the 10 muscles obtained from HM and LM Hanwoo steers. The proportions of SFA (saturated fatty acid), MUFA (monounsaturated fatty acid) and PUFA (polyunsaturated fatty acid) were significantly (p<0...
October 31, 2016: Korean Journal for Food Science of Animal Resources
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